YU46038B - Postopek za pripravo azoniaspironortropanolestrov - Google Patents
Postopek za pripravo azoniaspironortropanolestrovInfo
- Publication number
- YU46038B YU46038B YU224986A YU224986A YU46038B YU 46038 B YU46038 B YU 46038B YU 224986 A YU224986 A YU 224986A YU 224986 A YU224986 A YU 224986A YU 46038 B YU46038 B YU 46038B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- general formula
- residue
- alkyl
- hydrogen atom
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
POSTOPEK ZA PRIPRAVO AZONIASPIRONORTROPANOLESTROV, s splošno formulo I v kateri pomenijo R enega od naslednjih ostankov a) alkilenski ostanek s splošno formulo v kateri pomeni R3 atom vodika ali alkilno, benzilno, arilno, ali alkoksikarbonilno skupino in n stoji za celo število od 1 do 4, b) alkenilenski ostanek s splošno formulo v kateri pomenita R4 in R5, ki sta lahko enaka ali različna, atom vodika ali alkilni ali alkenilni ostanek, in n stoji za celo število od 1 do 4, c) azaalkilenski ostanek s splošno formulo v kateri pomeni R6 atom vodika, alkilno, alkoksikarbonilno ali acilno skupino in n stoji za celo število od 2 do 4, d) oksaalkilenski ostanek s splošno formulo -(CH2)n-O-(CH2)n- -v kateri stoji n za celo število od 2 do 4, e) epoksialkilenski ostanek s formulo f) o-fenilenski ostanek s splošno formulo g) peri-naftilenski ostanek s splošno formulo in h) 2,3-kinoksalinenski ostanek s splošno formulo pri čemer v formulah f) do h) ostanka X in Y neodvisno drug od drugega pomenita atom vodika ali alkilni ali alkoksi ostanek, R1 in R2, ki sta lahko enaka ali različna, atom vodika ali atom halogena ali alkilni, alkoksi, alkoilni, cikloheksilni, fenilni, alkilfenilni, alkoksifenilni, halogenofenilni, tienilni ali furilni ostanek, pri čemer vsebujejo alkilne skupine, ki se nahajajo v navedenih ostankih, 1 do 6 atomov ogljika in so lahko ravne ali razvejene, in A- anion 1- do 3- valentne mineralne kisline, z a) demetiliranjem tropina v nortropin, b) presnovo nortropina z dihalogenidi v ustrezne azonia spojine in c) zaestrenjem azonia spojin označen s tem, da A) izvedemo demetiliranje tropina s formulo II tako, da bodisi delamo s C1-C3-kloroalkanom, ki vsebuje najmanj eno skupino CCl3, v prisotnosti oksidacijskega sredstva v bazični vodni raztopini, bodisi presnovimo tropin z estrom klormravljinčne kisline v inertnem topilu v prisotnosti sredstva za vezanje kisline v 8-alkoksikarbonilnortropin in le-tega hidroliziramo v vodni raztopini z bazo, B) tako dobljeni nortropin s formulo III presnavljamo v dipolarnem aprotičnem topilu s spojino s splošno formulo A - R - A, v kateri imata A in R zgoraj navedene pomene, v prisotnosti sekundarnega ali terciarnega amina pri sobni temperaturi en do več dni, in C) tako dobljeno spojino s splošno formulo IV v kateri imata R in A- zgoraj navedene pomene, v brezvodnem, dipolarnem aprotičnem topilu zaestrimo z imidazolidom s splošno formulo V v kateri imata R1 in R2 zgoraj navedene pomene, v prisotnosti katalizatorja, D) in v primeru, da vsebuje ostanek R potem, ko je prešel skozi stopnji B in/ali C, eno ali več olefinskih dvojnih vezi v azonijevem obroču, te nenasičene spojine hidriramo v polarnem topilu s pomočjo katalizatorja iz žlahtne kovine v ustrezne nasičene spojine, pri čemer do
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI8612249A SI8612249A8 (sl) | 1985-12-27 | 1986-12-25 | Postopek za pripravo azoniaspironortropanolestrov |
HRP-2249/86A HRP930787A2 (en) | 1985-12-27 | 1993-04-05 | Azonyaspyronotropanolesters, process for their preparation and pharmaceutical preparations containing the same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19853546218 DE3546218A1 (de) | 1985-12-27 | 1985-12-27 | Azoniaspironortropanolester, verfahren zu deren herstellung und pharmazeutisches mittel |
DE19853546165 DE3546165A1 (de) | 1985-12-27 | 1985-12-27 | Verwendung von azoniaspironortropanolestern als asthmatherapeutikum und als broncholytikum |
Publications (2)
Publication Number | Publication Date |
---|---|
YU224986A YU224986A (en) | 1988-04-30 |
YU46038B true YU46038B (sh) | 1992-12-21 |
Family
ID=25839393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU224986A YU46038B (sh) | 1985-12-27 | 1986-12-25 | Postopek za pripravo azoniaspironortropanolestrov |
Country Status (18)
Country | Link |
---|---|
KR (1) | KR930000113B1 (xx) |
AT (1) | AT397962B (xx) |
AU (1) | AU584266B2 (xx) |
BE (1) | BE906054A (xx) |
CA (1) | CA1304369C (xx) |
CH (1) | CH677793A5 (xx) |
ES (1) | ES2004177A6 (xx) |
FI (1) | FI865295A (xx) |
FR (1) | FR2598417B1 (xx) |
GB (1) | GB2184726B (xx) |
HU (1) | HU201930B (xx) |
IT (1) | IT1198263B (xx) |
NL (1) | NL193184C (xx) |
PL (1) | PL150843B1 (xx) |
PT (1) | PT84022B (xx) |
SE (1) | SE8605531L (xx) |
SU (1) | SU1711674A3 (xx) |
YU (1) | YU46038B (xx) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA06003769A (es) * | 2003-11-04 | 2006-07-03 | Shire Lab Inc | Liberacion sostenida de moleculas farmacologicamente activas cargadas positivamente a partir de una matriz que contiene polimeros con atomos de oxigeno polarizados. |
WO2005046663A1 (en) * | 2003-11-04 | 2005-05-26 | Shire Laboratories, Inc. | Compositions of quaternary ammonium containing bioavailability enhancers |
CN101684117B (zh) * | 2008-09-27 | 2013-06-12 | 宁波市医药技术研究有限公司 | 去甲托品醇的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1194422B (de) * | 1963-03-05 | 1965-06-10 | Robert Pfleger Chem Fab Dr | Verfahren zur Herstellung von Azoniaspironortropanderivaten |
US3480626A (en) * | 1967-05-18 | 1969-11-25 | Chem Fab Dr R Pfleger | Certain azoniaspironortropine derivatives |
DE1670258C3 (de) * | 1967-08-04 | 1976-01-02 | C.H. Boehringer Sohn, 6507 Ingelheim | Verfahren zur Herstellung von N or scopolamin durch Entalkylierung tertiärer, cyclischer Amine |
IT1140998B (it) * | 1980-06-18 | 1986-10-10 | Valeas Ind Chimica E Farmaceut | Sali di endo-8-metil-8-sin-alchil-8-azoniabiciclo aperta par. quadrata 3.2.1. chiusa par. quadrata-ottan-3-alchilcarbossilati, processo per la loro preparazione e composizioni terapeutiche che li contengono come principio attivo |
-
1986
- 1986-12-19 AT AT0339286A patent/AT397962B/de not_active IP Right Cessation
- 1986-12-22 SE SE8605531A patent/SE8605531L/xx not_active Application Discontinuation
- 1986-12-22 CH CH5198/86A patent/CH677793A5/de not_active IP Right Cessation
- 1986-12-23 GB GB8630809A patent/GB2184726B/en not_active Expired - Fee Related
- 1986-12-23 PL PL1986263216A patent/PL150843B1/pl unknown
- 1986-12-23 FI FI865295A patent/FI865295A/fi not_active Application Discontinuation
- 1986-12-24 ES ES8603662A patent/ES2004177A6/es not_active Expired
- 1986-12-24 NL NL8603303A patent/NL193184C/nl not_active IP Right Cessation
- 1986-12-24 PT PT84022A patent/PT84022B/pt not_active IP Right Cessation
- 1986-12-24 IT IT22877/86A patent/IT1198263B/it active
- 1986-12-24 AU AU66985/86A patent/AU584266B2/en not_active Ceased
- 1986-12-25 YU YU224986A patent/YU46038B/sh unknown
- 1986-12-26 SU SU864028726A patent/SU1711674A3/ru active
- 1986-12-26 FR FR8618210A patent/FR2598417B1/fr not_active Expired - Fee Related
- 1986-12-27 HU HU865367A patent/HU201930B/hu not_active IP Right Cessation
- 1986-12-27 KR KR1019860011482A patent/KR930000113B1/ko not_active IP Right Cessation
- 1986-12-29 CA CA000526376A patent/CA1304369C/en not_active Expired - Fee Related
- 1986-12-29 BE BE2/61142A patent/BE906054A/fr not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HU201930B (en) | 1991-01-28 |
NL193184C (nl) | 1999-02-02 |
SE8605531L (sv) | 1987-06-28 |
AT397962B (de) | 1994-08-25 |
CH677793A5 (xx) | 1991-06-28 |
PT84022A (en) | 1987-01-01 |
KR930000113B1 (ko) | 1993-01-09 |
IT1198263B (it) | 1988-12-21 |
KR870005998A (ko) | 1987-07-08 |
PT84022B (pt) | 1989-07-31 |
HUT43060A (en) | 1987-09-28 |
NL193184B (nl) | 1998-10-01 |
ATA339286A (de) | 1993-12-15 |
GB2184726A (en) | 1987-07-01 |
AU6698586A (en) | 1987-07-02 |
GB8630809D0 (en) | 1987-02-04 |
FR2598417B1 (fr) | 1993-10-29 |
IT8622877A0 (it) | 1986-12-24 |
PL150843B1 (en) | 1990-07-31 |
GB2184726B (en) | 1990-10-03 |
FI865295A0 (fi) | 1986-12-23 |
FR2598417A1 (fr) | 1987-11-13 |
ES2004177A6 (es) | 1988-12-16 |
SE8605531D0 (sv) | 1986-12-22 |
NL8603303A (nl) | 1987-07-16 |
YU224986A (en) | 1988-04-30 |
CA1304369C (en) | 1992-06-30 |
FI865295A (fi) | 1987-06-28 |
AU584266B2 (en) | 1989-05-18 |
IT8622877A1 (it) | 1988-06-24 |
BE906054A (fr) | 1987-06-29 |
PL263216A1 (en) | 1988-04-14 |
SU1711674A3 (ru) | 1992-02-07 |
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