YU45932B - Postupak za dobijanje 2-benzimidazolilalkiltio ili sulfinil ili sulfonil derivata - Google Patents
Postupak za dobijanje 2-benzimidazolilalkiltio ili sulfinil ili sulfonil derivataInfo
- Publication number
- YU45932B YU45932B YU6087A YU6087A YU45932B YU 45932 B YU45932 B YU 45932B YU 6087 A YU6087 A YU 6087A YU 6087 A YU6087 A YU 6087A YU 45932 B YU45932 B YU 45932B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- benzimidazolylalkylthio
- sulfinyl
- preparation
- sulfonyl derivatives
- present
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
Abstract
POSTUPAK ZA DOBIJANJE 2-BENZIMIDAZOLILALKILTIO ILI SULFINIL ILI SULFONIL DERIVATA opste formule I kao i njihovih terapeutski prihvatljivih soli, u kojoj X predstavlja atom azota (N) ili atom ugljenika vezan za radikal R8 (C-C8); Y predstavlja atom azota (N) ili grupu N-oksid (N O); Z predstavlja atom sumpora (S), grupu sulfinil (S O) ili grupu sulfonil (O S O); R1 i R2 identicni ili razliciti, predstavljaju atom vodonika, halogen, pravi ili racvasti nizi C1-4alkil, nitro grupa (NO2), trifluorometil (CF3), C1-4alkoksi ili alkiltio, karboksilni radikal (COOH), karboksialkil, kao sto je karboksimetil ili karboksietil, radikal alkanoli ili ariloil (-C-R9); O R3 predstavlja atom vodonika, C1-4alkil radikal, karbonil vezan za radikal R10(-C-R10); O R4 predstavlja atom vodonika, C1-4alkil radikal; R5 predstavlja atom vodonika, radikal metil, hidroksi, alkoksi; R6 predstavlja atom vodonika, radikal metil, nitro (NO2), alkoksi; R7 predstavlja atom vodonika, C1-4alkil radikal, C1-4alkoksi radikal; R8 predstavlja atom vodonika, metil radikal; R9 predstavlja C1-4alkil, C3-6cikloalkil, aril kao sto je fenil, i R10 predstavlja C1-4alkil, alkoksi ili ariloksi ili arilalkoksi, sa izuzetkom jedinjenja formule I u kojoj X je CH, Y je N, Z je S, i R1 do R7 su H; naznacen time, sto reaguje jedinjenje opste formule II sa jedinjenjem opste formule III u kojima X, Y, R1 do R7 imaju napred navedena znacenja, jedan od radikala Z1 i Z2 ima znacenje -SH dok se drugi bira iz grupe koju cine halogeni prvenstveno fluor, hlor ili brom, radikali obrazovani od esterifikovanih grupa i koji su reaktivni narocito acetiloksi, toziloksi ili meziloksi, ili grupe alkiltio ili alkilsulfinil kao sto su metil-tio ili metilsulfinil; i sto se u slucaju kad Z je atom sumpora proizvod reakcije po potrebi oksidise stehiometrijskom kolicinom oksidacionog sredstva i Z postaje sulfinil grupa (S - O), a kad se oksidise sa dva ili tri puta vecom kolicinom oksidacionog sredstva onda Z predstavlja sulfonil grupu (O - S - O), pri cemu se upotrebljava oksidaciono sredstvo iz grupe koju cine vodonik peroksid, per-kiseline na primer m-hlorperbenzoeva, azotna kiselina, mangan dioksid, hlor, brom ili sulfuril hlorid. Prijava sadrzi jos 4 zahteva.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8600695A FR2593178B1 (fr) | 1986-01-20 | 1986-01-20 | Derives de 2-benzimidazolylalkylthio (ou sulfinyle ou sulfonyle) leur preparation et leur application en tant que medicaments. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU6087A YU6087A (en) | 1988-08-31 |
| YU45932B true YU45932B (sh) | 1992-09-07 |
Family
ID=9331254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU6087A YU45932B (sh) | 1986-01-20 | 1987-01-19 | Postupak za dobijanje 2-benzimidazolilalkiltio ili sulfinil ili sulfonil derivata |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4791114A (sh) |
| EP (1) | EP0234980B1 (sh) |
| JP (1) | JPS62181274A (sh) |
| KR (1) | KR890002291B1 (sh) |
| CN (1) | CN1016060B (sh) |
| AT (1) | ATE80625T1 (sh) |
| AU (1) | AU587680B2 (sh) |
| BR (1) | BR8700191A (sh) |
| CA (1) | CA1296336C (sh) |
| DD (1) | DD259401A5 (sh) |
| DE (2) | DE3781703T2 (sh) |
| DK (1) | DK23887A (sh) |
| ES (1) | ES2003658A6 (sh) |
| FR (1) | FR2593178B1 (sh) |
| GR (2) | GR880300076T1 (sh) |
| HU (1) | HU197566B (sh) |
| NO (1) | NO170931C (sh) |
| PL (1) | PL154487B1 (sh) |
| PT (1) | PT84141B (sh) |
| SU (1) | SU1586513A3 (sh) |
| YU (1) | YU45932B (sh) |
| ZA (1) | ZA87343B (sh) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK8600939A (sh) * | 1985-03-05 | 1986-09-06 | ||
| SE8804628D0 (sv) * | 1988-12-22 | 1988-12-22 | Ab Haessle | New compounds |
| US6245913B1 (en) | 1999-06-30 | 2001-06-12 | Wockhardt Europe Limited | Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole |
| ES2171116B1 (es) * | 2000-04-14 | 2003-08-01 | Esteve Quimica Sa | Procedimiento para la obtencion de derivados de (((piridil sustituido)metil)tio)bencimidazol. |
| GB0108592D0 (en) * | 2001-04-05 | 2001-05-23 | Merck Sharp & Dohme | Therapeutic agents |
| US20120041030A1 (en) * | 2009-04-09 | 2012-02-16 | Masaichi Yamamoto | Pyridine thio derivative, and pharmaceutical composition which contains same and has anti-helicobacter pylori action |
| CA2959208C (en) | 2014-08-29 | 2023-09-19 | Tes Pharma S.R.L. | Pyrimidine derivatives and their use as inhibitors of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1234058A (sh) * | 1968-10-21 | 1971-06-03 | ||
| US4045564A (en) * | 1974-02-18 | 1977-08-30 | Ab Hassle | Benzimidazole derivatives useful as gastric acid secretion inhibitors |
| SE418966B (sv) * | 1974-02-18 | 1981-07-06 | Haessle Ab | Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan |
| US4619944A (en) * | 1981-06-01 | 1986-10-28 | Usv Pharmaceutical Corporation | Antihypertensive compounds |
-
1986
- 1986-01-20 FR FR8600695A patent/FR2593178B1/fr not_active Expired
-
1987
- 1987-01-15 US US07/003,442 patent/US4791114A/en not_active Expired - Fee Related
- 1987-01-16 AU AU67621/87A patent/AU587680B2/en not_active Ceased
- 1987-01-16 DK DK023887A patent/DK23887A/da not_active Application Discontinuation
- 1987-01-16 BR BR8700191A patent/BR8700191A/pt not_active Application Discontinuation
- 1987-01-19 EP EP87400112A patent/EP0234980B1/fr not_active Expired - Lifetime
- 1987-01-19 ES ES8700108A patent/ES2003658A6/es not_active Expired
- 1987-01-19 CA CA000527612A patent/CA1296336C/fr not_active Expired - Fee Related
- 1987-01-19 SU SU874028881A patent/SU1586513A3/ru active
- 1987-01-19 HU HU87137A patent/HU197566B/hu not_active IP Right Cessation
- 1987-01-19 DD DD87299334A patent/DD259401A5/de unknown
- 1987-01-19 PT PT84141A patent/PT84141B/pt not_active IP Right Cessation
- 1987-01-19 YU YU6087A patent/YU45932B/sh unknown
- 1987-01-19 DE DE8787400112T patent/DE3781703T2/de not_active Expired - Fee Related
- 1987-01-19 DE DE198787400112T patent/DE234980T1/de active Pending
- 1987-01-19 ZA ZA870343A patent/ZA87343B/xx unknown
- 1987-01-19 AT AT87400112T patent/ATE80625T1/de not_active IP Right Cessation
- 1987-01-20 KR KR1019870000517A patent/KR890002291B1/ko not_active IP Right Cessation
- 1987-01-20 CN CN87100363A patent/CN1016060B/zh not_active Expired
- 1987-01-20 NO NO870228A patent/NO170931C/no unknown
- 1987-01-20 JP JP62011195A patent/JPS62181274A/ja active Pending
- 1987-01-20 PL PL1987263733A patent/PL154487B1/pl unknown
-
1988
- 1988-12-16 GR GR88300076T patent/GR880300076T1/el unknown
-
1992
- 1992-10-29 GR GR920402430T patent/GR3006109T3/el unknown
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