YU134591A - Postupak i intermedijer za dobijanje 2-hidroksi-3-sulfido-3- fenilpropionske kiseline - Google Patents

Postupak i intermedijer za dobijanje 2-hidroksi-3-sulfido-3- fenilpropionske kiseline

Info

Publication number
YU134591A
YU134591A YU134591A YU134591A YU134591A YU 134591 A YU134591 A YU 134591A YU 134591 A YU134591 A YU 134591A YU 134591 A YU134591 A YU 134591A YU 134591 A YU134591 A YU 134591A
Authority
YU
Yugoslavia
Prior art keywords
sulphido
hydroxy
procedure
preparation
4alkyl
Prior art date
Application number
YU134591A
Other languages
English (en)
Inventor
A.A. Jarmas
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of YU134591A publication Critical patent/YU134591A/sh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/48Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

POSTUPAK I INTERMEDIJER ZA DOBIJANJE 2-HIDROKSI-3-SULFIDO-3- FENILPROPIONSKE KISELINE, sadašnji pronalazak odnosi se na intermedijerna jedinjenja formule: u kojoj R1 predstavlja (L)a-(CH2)b-(T)c-B:a je 0 ili 1; b je od 3 do 14; c je 0 ili 1; L i T su nezavisno sumpor, kiseonik, CH=CH, C C ili CH2; B je vodonik, C1-4alkil, etinil, trifluorometil, izopropenil, furanil, tienil, cikloheksil ili fenil koji je po potrebi monosupstituisan sa Br, C1, CF3, C1-4alkoksi, C1-4alkil, metiltio ili trifluorometiltio; R2 i A2 su nezavisno odabrani od vodonika, CF3, C1-4alkil, C1- 4alkoksi, F, Cl, Br, J, OH, NO2 ili NH2; ili kada su R1 i A oba vodonici, R2 predstavlja (L)a-(CH2)b-(T)c-B, gde su a,b,c,L,T i B kao što je definisano gore; i M je vodonik, Li, Na, K, NH4 ili organski amonijum katjon, i na njihovu primenu u novom postupku za sintezu antagonista leukotriena, 2-hidroksi-3-fenilpropionske kiseline, koji ima formulu: u prijavi je opisan i postupak za dobijanje jedinjenja formule V.
YU134591A 1990-08-01 1991-08-01 Postupak i intermedijer za dobijanje 2-hidroksi-3-sulfido-3- fenilpropionske kiseline YU134591A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56162190A 1990-08-01 1990-08-01

Publications (1)

Publication Number Publication Date
YU134591A true YU134591A (sh) 1994-01-20

Family

ID=24242732

Family Applications (1)

Application Number Title Priority Date Filing Date
YU134591A YU134591A (sh) 1990-08-01 1991-08-01 Postupak i intermedijer za dobijanje 2-hidroksi-3-sulfido-3- fenilpropionske kiseline

Country Status (23)

Country Link
US (1) US5693857A (sh)
EP (1) EP0541706B1 (sh)
JP (1) JPH06500105A (sh)
CN (1) CN1059521A (sh)
AT (1) ATE127784T1 (sh)
AU (1) AU652776B2 (sh)
BR (1) BR9106722A (sh)
CA (1) CA2088355A1 (sh)
CZ (1) CZ10593A3 (sh)
DE (1) DE69113048T2 (sh)
FI (1) FI930383A0 (sh)
HU (2) HU9401975D0 (sh)
IE (1) IE912703A1 (sh)
IL (1) IL99049A0 (sh)
MA (1) MA22482A1 (sh)
MX (1) MX9100473A (sh)
NZ (1) NZ239200A (sh)
PT (1) PT98543A (sh)
SK (1) SK5093A3 (sh)
WO (1) WO1992002519A1 (sh)
YU (1) YU134591A (sh)
ZA (1) ZA916013B (sh)
ZW (1) ZW10891A1 (sh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2658513B1 (fr) * 1990-02-21 1994-02-04 Rhone Poulenc Sante Procede de preparation de l'acide cis-beta-phenylglycidique-(2r,3r).
US20060020142A1 (en) * 2004-07-23 2006-01-26 Pessoa Cavalcanti Fernando A Catalytic (AMM)oxidation process for conversion of lower alkanes to carboxylic acids and nitriles

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8320943D0 (en) * 1983-08-03 1983-09-07 Lilly Industries Ltd Organic compounds
US4655189A (en) * 1984-03-31 1987-04-07 Toyota Jidosha Kabushiki Kaisha Device for processing fuel vapor
US4937253A (en) * 1985-04-19 1990-06-26 Smithkline Beecham Corporation Ester prodrugs
AU595193B2 (en) * 1985-04-19 1990-03-29 Smithkline Beckman Corporation Thio substituted acidic derivatives
US4874792A (en) * 1985-04-19 1989-10-17 Smithkline Beckman Corporation Thiophenyl Alkanoic acids useful as leukotriene antagonists
CA1334200C (en) * 1987-06-24 1995-01-31 James Simpson Frazee Leukotriene antagonists
AU610528B2 (en) * 1987-10-29 1991-05-23 Smithkline Beckman Corporation Leukotriene antagonists
JP2627651B2 (ja) * 1988-10-17 1997-07-09 アネルバ株式会社 マグネトロンスパッタリング装置
US5110959A (en) * 1989-06-14 1992-05-05 Smithkline Beckman Corp. Process for preparation of epoxy esters and intermediates prepared thereby

Also Published As

Publication number Publication date
SK5093A3 (en) 1993-10-06
HU9401975D0 (en) 1994-09-28
PT98543A (pt) 1992-06-30
AU652776B2 (en) 1994-09-08
BR9106722A (pt) 1993-08-31
NZ239200A (en) 1994-08-26
CZ10593A3 (en) 1994-01-19
MX9100473A (es) 1992-04-01
FI930383A (fi) 1993-01-29
EP0541706A4 (en) 1993-12-01
CN1059521A (zh) 1992-03-18
WO1992002519A1 (en) 1992-02-20
DE69113048T2 (de) 1996-02-22
AU8443191A (en) 1992-03-02
IL99049A0 (en) 1992-07-15
US5693857A (en) 1997-12-02
ATE127784T1 (de) 1995-09-15
HUT68410A (en) 1995-06-28
EP0541706A1 (en) 1993-05-19
IE912703A1 (en) 1992-02-12
MA22482A1 (fr) 1992-12-31
DE69113048D1 (de) 1995-10-19
EP0541706B1 (en) 1995-09-13
HU9300257D0 (en) 1993-06-28
CA2088355A1 (en) 1992-02-02
ZW10891A1 (en) 1991-11-13
FI930383A0 (fi) 1993-01-29
JPH06500105A (ja) 1994-01-06
ZA916013B (en) 1992-09-30

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