Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/20—Halogens; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/26—Aluminium; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/37—Esters of carboxylic acids
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
  • A61K8/86—Polyethers
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

• the present invention relates to a denture adhesive remover that removes denture adhesive that has adhered to the oral cavity or dentures.
• denture adhesives When fitting dentures into the mouth, denture adhesives may be used. Denture adhesives are applied to the surface of the denture base, which serves as the base for the dentures, to increase adhesion and adhesion to the gums and upper jaw, preventing the dentures from slipping when eating or speaking.
• Denture adhesives There are various types of denture adhesives, including cream, powder, and cushion types. Among them, “Polygrip (registered trademark),” which is classified as a cream type, has the top market share among denture adhesives and is sold in large quantities not only at dental clinics but also at general drugstores. Denture adhesives exert their adhesive properties by absorbing saliva in the oral cavity, improving the retention and stability of dentures.
• the main adhesive components are water-swellable, water-soluble polymer compounds such as sodium/calcium methoxyethylene maleic anhydride copolymer salt (PVMA salt) and carboxymethylcellulose (CMC).
• Cream-type denture adhesives, including Polygrip also contain hydrophobic ointment base ingredients such as liquid paraffin and white petrolatum. The denture adhesive is retained in the oral cavity by a balance between the water absorption and viscosity of the water-soluble polymer and the resistance to leaching provided by the hydrophobic ointment base ingredients.
• dentures and denture adhesives are not retained in the mouth permanently and must be periodically removed from the mouth and cleaned.
• Current methods for cleaning dentures include mechanical cleaning using a brush, etc., and chemical cleaning using detergents. It is desirable that neither cleaning method damages or deforms the dentures.
• denture adhesive is highly adhesive and adheres strongly to the mouth and dentures. Applying too much force to remove it can lead to bleeding from the oral mucosa, pain for the patient, and damage or deformation of the dentures, making active cleaning difficult both practically and psychologically.
• the complex structure of the mouth, including the teeth, dental necks, and unevenness of the dentures makes it difficult to remove denture adhesive.
• cooperation from denture wearers is not available or that it is difficult to take the time or effort to remove the denture adhesive, which can result in denture adhesive remaining in the mouth or on the dentures.
• Patent Document 1 describes that a denture adhesive remover containing 30 to 60% by weight of a lower alcohol, water, a thickener, and a surfactant can effectively remove denture adhesive and also has a bactericidal effect.
• the remover taught in Patent Document 1 cannot completely remove the denture adhesive from the denture even when force is applied after the remover is applied to the denture and denture adhesive.
• the objective of the present invention is to provide a denture adhesive remover that can sufficiently remove denture adhesive adhering to dentures.
• denture adhesives In order to solve the above problems, the present inventors focused on the chemical properties of denture adhesives. They believed that by chemically inhibiting the function of the water-swelling, water-soluble polymer compounds contained in denture adhesives and reducing their adhesiveness, denture adhesives adhering to dentures could be effectively removed. They then discovered that a formulation containing a polar base and a specific metal compound could adequately remove denture adhesives adhering to dentures.
• a composition comprising a polar base and at least one metal compound, wherein the metal compound is (1) A salt of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron and at least one compound selected from the group consisting of an inorganic acid, an organic acid, and ammonia, or a hydrate thereof; (2) an oxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof; and (3) a denture adhesive remover which is a compound selected from the group consisting of a hydroxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof.
• the polar base is at least one selected from the group consisting of lower alcohols, higher alcohols, polyhydric alcohols, and glycol ethers.
• a denture adhesive remover according to any one of [1] to [3], wherein the concentration of the polar base is 1 to 99% by mass based on the total amount of the denture adhesive remover.
• a denture adhesive remover according to any one of [1] to [4], wherein the concentration of the metal compound is 0.01 to 97% by mass based on the total amount of the denture adhesive remover.
• a denture adhesive remover according to any one of [1] to [5], wherein the content of the metal compound is 0.0005 to 20 parts by mass per part by mass of the polar base.
• the denture adhesive remover according to any one of [1] to [6], further comprising a surfactant.
• a denture adhesive remover according to any one of [1] to [11], which is used to remove denture adhesive from dentures or the oral cavity.
• a composition comprising a polar base and at least one metal compound, wherein the metal compound is (1) A salt of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron and at least one compound selected from the group consisting of an inorganic acid, an organic acid, and ammonia, or a hydrate thereof; (2) An oxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof; and (3) A hydroxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof, for use as a denture adhesive remover or for producing a denture adhesive remover.
• a composition comprising a polar base and at least one metal compound, wherein the metal compound is (1) A salt of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron and at least one compound selected from the group consisting of an inorganic acid, an organic acid, and ammonia, or a hydrate thereof;
• a method for removing denture adhesive comprising the step of applying to the denture adhesive an effective amount of a composition which is a compound selected from the group consisting of: (2) an oxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof; and (3) a hydroxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof.
• denture adhesive removers (hereinafter sometimes referred to as "removals”) could not completely remove denture adhesive that had adhered to dentures even when strong force was applied, but the denture adhesive remover of the present invention chemically weakens the adhesion of denture adhesive, so that denture adhesive can be removed with less force or no force at all compared to conventional removers. Furthermore, the remover of the present invention acts on denture adhesive, changing its properties and removing it, so it can be removed not only from dentures but also from the oral mucosa. Furthermore, it is suitable for removing denture adhesive that has adhered or stuck to the oral mucosa because it can sufficiently remove denture adhesive without containing any irritating ingredients or ingredients that may have adverse effects on the human body.
• removers remove denture adhesive that has adhered to the oral mucosa by removing the denture from the oral cavity, but no removers exist that can remove denture adhesive that has adhered to the oral cavity.
• the remover of the present invention has high commercial value because it can effectively remove denture adhesive that has adhered to the oral cavity.
• denture adhesives adhere strongly to the denture base and oral mucosa because the carboxyl group-containing polymer ionizes and becomes negatively charged when it comes into contact with water, causing electrostatic interaction with the denture base and oral mucosa. Although not limited to this mechanism, it is thought that the polar base of the remover of the present invention inhibits this electrostatic interaction, thereby weakening the adhesion of the denture adhesive to dentures.
• the carboxyl group-containing polymers contained in many denture adhesives ionize and become negatively charged when they come into contact with water, and thicken due to electrostatic repulsion within and between molecules and steric hindrance; it is thought that the action of metal ions reduces the viscosity, making them more likely to peel off from dentures and the oral cavity.
• Photographs of the inside of the mouth before and after wiping off denture adhesive adhering to the mouth with the preparation of Example 57 Photographs of the inside of the oral cavity before and after wiping off denture adhesive adhering to the oral cavity using the formulation of Comparative Example 2.
• the denture adhesive remover of the present invention comprises a polar base and at least one metal compound, wherein the metal compound is (1) A salt of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron and at least one compound selected from the group consisting of an inorganic acid, an organic acid, and ammonia, or a hydrate thereof; (2) an oxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof; and (3) a hydroxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof.
• Polar bases used in compositions for external use can be used, such as lower alcohols (alcohols having 1 to 5 carbon atoms, preferably 2 to 4 carbon atoms), higher alcohols (aliphatic alcohols having 6 to 24 carbon atoms, preferably 12 to 18 carbon atoms), polyhydric alcohols, and glycol ethers.
• the polar bases may be used alone or in combination.
• the polar base may be in the form of a liquid, paste, powder, or flake at room temperature depending on the type and molecular weight, and the properties of the remover can be adjusted by using a combination of polar bases.
• Examples of lower alcohols include methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, and amyl alcohol.
• Examples of higher alcohols include linear saturated higher alcohols such as hexyl alcohol, heptyl alcohol, capryl alcohol, nonyl alcohol, decyl alcohol, undecanol, lauryl alcohol, myristyl alcohol, cetanol, cetearyl alcohol, stearyl alcohol, arachidyl alcohol, and behenyl alcohol; linear unsaturated higher alcohols such as oleyl alcohol, linoleyl alcohol, and lignoceryl alcohol; and branched saturated higher alcohols such as hexyldecanol, isostearyl alcohol, octyldodecanol, and decyltetradecanol.
• polyhydric alcohols examples include propylene glycol, dipropylene glycol, polypropylene glycol, 1,3-butylene glycol, glycerin, diglycerin, isoprene glycol, and polyethylene glycol.
• Polyhydric alcohols may be polymers such as polypropylene glycol and polyethylene glycol, or non-polymers, but polymers are preferred.
• glycol ethers include ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether, and dipropylene glycol monopropyl ether.
• the polar base is preferably a lower alcohol or a polyhydric alcohol, with ethanol, isopropyl alcohol, polypropylene glycol, and polyethylene glycol being particularly preferred.
• the concentration of the polar base can be 1% by weight or more, 5% by weight or more, 10% by weight or more, 20% by weight or more, 30% by weight or more, 40% by weight or more, or 50% by weight or more. Within this range, denture adhesive can be effectively removed.
• the concentration of the polar base, based on the total amount of the remover can be 99% by weight or less, 98% by weight or less, 97% by weight or less, 96% by weight or less, 95% by weight or less, 93% by weight or less, 90% by weight or less, 80% by weight or less, 70% by weight or less, or 60% by weight or less. Within this range, a sufficient amount of other ingredients such as metal compounds can be blended, resulting in a formulation that exhibits a high denture adhesive removal effect.
• the concentration of the polar base relative to the total amount of remover is: 1-99 mass%, 1-98 mass%, 1-97 mass%, 1-96 mass%, 1-95 mass%, 1-93 mass%, 1-90 mass%, 1-80 mass%, 1-70 mass%, 1-60 mass%; 5-99 mass%, 5-98 mass%, 5-97 mass%, 5-96 mass%, 5-95 mass%, 5-93 mass%, 5-90 mass%, 5-80% by mass, 5-70% by mass, 5-60% by mass; 10-99% by mass, 10-98% by mass, 10-97% by mass, 10-96% by mass, 10-95% by mass, 10-93% by mass, 10 ⁇ 90% by mass, 10-80% by mass, 10-70% by mass, 10-60% by mass; 20-99% by mass, 20-98% by mass, 20-97% by mass, 20-96% by mass, 20-95% by mass, 2 0 to 93 mass%, 20 to 90 mass%, 20 to 80 mass%, 20 to 70 mass%, 20 to 60 mass%; 30 to 99 mass%, 30 to 98 mass%
• the remover contains a polyhydric alcohol
• its concentration can be 1% by weight or more, 5% by weight or more, 10% by weight or more, 20% by weight or more, 30% by weight or more, 40% by weight or more, or 50% by weight or more.
• denture adhesive can be effectively removed.
• the polyhydric alcohol concentration can be 99% by weight or less, 98% by weight or less, 97% by weight or less, 96% by weight or less, 95% by weight or less, 93% by weight or less, 90% by weight or less, 80% by weight or less, 70% by weight or less, or 60% by weight or less, based on the total amount of the remover.
• a sufficient amount of other ingredients such as metal compounds can be blended, resulting in a formulation that exhibits a high denture adhesive removal effect.
• the concentration of polyhydric alcohol relative to the total amount of remover is 1-99 mass%, 1-98 mass%, 1-97 mass%, 1-96 mass%, 1-95 mass%, 1-93 mass%, 1-90 mass%, 1-80 mass%, 1-70 mass%, 1-60 mass%; 5-99 mass%, 5-98 mass%, 5-97 mass%, 5-96 mass%, 5-95 mass%, 5-93 mass%, 5-90 mass%.
• the remover contains a lower alcohol
• its concentration can be 5% by weight or more, 10% by weight or more, 20% by weight or more, 25% by weight or more, 30% by weight or more, 40% by weight or more, or 50% by weight or more.
• denture adhesive can be effectively removed.
• the concentration of the lower alcohol can be 40% by weight or less, 35% by weight or less, 30% by weight or less, 20% by weight or less, 15% by weight or less, 10% by weight or less, or 5% by weight or less, based on the total amount of the remover.
• a sufficient amount of other metal compounds can be blended, resulting in a formulation that exhibits a high denture adhesive removal effect.
• irritation to the oral mucosa is reduced, making it even more suitable for use as an oral denture adhesive remover.
• the concentration of the lower alcohol relative to the total amount of the remover can be 5-40% by mass, 5-35% by mass, 5-30% by mass, 5-20% by mass, 5-15% by mass, 5-10% by mass; 10-40% by mass, 10-35% by mass, 10-30% by mass, 10-20% by mass, 10-15% by mass; 20-40% by mass, 20-35% by mass, 20-30% by mass; 25-40% by mass, 25-35% by mass, 25-30% by mass; 30-40% by mass, 30-35% by mass.
• metal compounds include salts of at least one metal selected from sodium, potassium, calcium, magnesium, aluminum, zinc, and iron with at least one selected from inorganic acids, organic acids, and ammonia, or hydrates thereof.
• inorganic acids include hydrochloric acid, carbonic acid, phosphoric acid, nitric acid, nitrous acid, sulfuric acid, sulfurous acid, thiosulfuric acid, silicic acid, and hydrofluoric acid.
• Phosphates can be excluded from inorganic acid salts, and calcium phosphate can be excluded in particular.
• organic acids include lactic acid, acetic acid, citric acid, hexacyanoic acid, and gluconic acid.
• organic acid salts include stearates, and calcium stearate can be excluded in particular.
• the metal compound may be an oxide of at least one metal selected from sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof. Magnesium oxide can be excluded from the oxides.
• Examples of the metal compound include hydroxides of at least one metal selected from sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, and hydrates thereof.
• the metal compound may contain two or more kinds of metals and may also contain two or more kinds of counter ions of the metal ions, for example, salts of the above metals with organic or inorganic acids and ammonia.
• metal compounds include sodium chloride, sodium carbonate, sodium bicarbonate, sodium sulfate (e.g., anhydrous sodium sulfate), sodium sulfite, sodium thiosulfate, sodium acetate, sodium nitrite, sodium fluoride, sodium lactate, sodium acetate, sodium citrate, sodium gluconate, and sodium hydroxide; potassium chloride, potassium fluoride, potassium carbonate, potassium bicarbonate, potassium phosphate, potassium lactate, potassium acetate, potassium citrate, potassium gluconate, and potassium aluminum sulfate; calcium sulfate, calcium nitrate, calcium bicarbonate, calcium chloride, calcium oxide, calcium lactate, calcium citrate, and calcium acetate; magnesium chloride, magnesium sulfate, magnesium nitrate, magnesium citrate, and magnesium acetate; aluminum chloride, aluminum sulfate, aluminum phosphate, aluminum ammonium sulfate, aluminum nitrate, aluminum oxide, and aluminum lactate; zinc
• preferred metal compounds include sodium carbonate, sodium chloride, sodium sulfate (e.g., anhydrous sodium sulfate), sodium sulfite, sodium thiosulfate, sodium hydroxide; potassium fluoride, potassium hexacyanoferrate (III), potassium hydroxide, potassium aluminum sulfate, potassium acetate; calcium acetate, calcium chloride, calcium lactate, calcium oxide; magnesium chloride, magnesium nitrate, magnesium sulfate, magnesium acetate; aluminum lactate, aluminum sulfate, aluminum phosphate, ammonium aluminum sulfate, aluminum oxide; zinc fluoride; zinc chloride, zinc fluoride, zinc nitrate; iron chloride, iron sulfate, ammonium iron sulfate, potassium iron hexacyanoate (e.g., potassium iron hexacyanoate (III)); and hydrates thereof, which provide particularly excellent removal effects.
• sodium carbonate sodium chloride, sodium sulfate
• a compound is selected from these that does not irritate the oral mucosa or has an unpleasant taste, or has only a small amount of it, it will be even more suitable as an agent for removing denture adhesive from the oral cavity.
• metal compounds used in the present invention can be compounds that generate metal ions (especially a certain amount of metal ions) in the remover or in the remover mixed with water during use.
• the concentration of the metal compound in the remover can be 0.01% by weight or more, 0.05% by weight or more, 0.1% by weight or more, 0.5% by weight or more, 1% by weight or more, 5% by weight or more, 10% by weight or more, or 20% by weight or more, based on the total amount of the remover. Within this range, denture adhesive can be effectively removed.
• the concentration of the metal compound in the remover can be 97% by weight or less, 95% by weight or less, 90% by weight or less, 80% by weight or less, 70% by weight or less, 60% by weight or less, 50% by weight or less, 40% by weight or less, or 30% by weight or less, based on the total amount of the remover. Within this range, a sufficient amount of a polar base or the like can be blended, resulting in a formulation that exhibits a high denture adhesive removal effect.
• the concentration of metal compounds relative to the total amount of remover is 0.01 to 97 mass%, 0.01 to 95 mass%, 0.01 to 90 mass%, 0.01 to 80 mass%, 0.01 to 70 mass%, 0.01 to 60 mass%, 0.01 to 50 mass%, 0.01 to 40 mass%, 0.01 to 30 mass%; 0.05 to 97 mass%, 0.05 to 95 mass%, 0.05 to 90 mass%, 0.05 to 80 mass%, 0.05 to 70 mass%, 0.05-60% by mass, 0.05-50% by mass, 0.05-40% by mass, 0.05-30% by mass; 0.1-97% by mass, 0.1-95% by mass, 0.1-90% by mass, 0.1-80% by mass, 0.1-7 0% by mass, 0.1-60% by mass, 0.1-50% by mass, 0.1-40% by mass, 0.1-30% by mass; 0.5-97% by mass, 0.5-95% by mass, 0.5-90% by mass, 0.5-80% by mass, 0.5-7 0% by mass, 0.5-60% by mass, 0.5-50% by mass, 0.5
• the content of the metal compound in the remover can be at least 0.0005 parts by weight, at least 0.001 parts by weight, at least 0.005 parts by weight, at least 0.01 parts by weight, at least 0.05 parts by weight, or at least 0.1 parts by weight per part by weight of the polar base. Within this range, denture adhesive can be effectively removed.
• the content of the metal compound in the remover can be 20 parts by weight or less, 10 parts by weight or less, 8 parts by weight or less, 5 parts by weight or less, 3 parts by weight or less, 2 parts by weight or less, 1 part by weight or less, or 0.5 parts by weight or less per part by weight of the polar base. Within this range, a sufficient amount of other polar bases can be blended, resulting in a formulation that exhibits a high denture adhesive removal effect.
• the ratio of the metal compound content to 1 part by mass of polar base is 0.0005 to 20 parts by mass, 0.0005 to 10 parts by mass, 0.0005 to 8 parts by mass, 0.0005 to 5 parts by mass, 0.0005 to 3 parts by mass, 0.0005 to 2 parts by mass, 0.0005 to 1 part by mass, 0.0005 to 0.5 parts by mass, or 0.001 to 20 parts by mass.
• the concentration and content of the metal compound are the concentration and content excluding the water of hydration.
• the denture adhesive remover of the present invention may or may not contain water. If it contains water, preparation before use is not required and it can be applied directly to the oral cavity or dentures, resulting in a formulation that is highly convenient for use. If it does not contain water, preparation before use by adding water is required, but by not including water, the weight of the formulation itself can be reduced, resulting in a formulation that is highly convenient for distribution.
• the concentration can be 0.001% by weight or more, 0.01% by weight or more, 0.1% by weight or more, 1% by weight or more, 5% by weight or more, 10% by weight or more, 20% by weight or more, 30% by weight or more, or 40% by weight or more, based on the total weight of the remover.
• the formulation can fully exert its denture adhesive removing effect without adding water from outside.
• the water concentration can be 90% by weight or less, 80% by weight or less, 70% by weight or less, 60% by weight or less, or 50% by weight or less, based on the total amount of the remover.
• sufficient amounts of metal compound and polar base can be incorporated, resulting in a formulation that can fully demonstrate the denture adhesive removal effect.
• the concentration of water relative to the total amount of remover is: 0.001 to 90 mass%, 0.001 to 80 mass%, 0.001 to 70 mass%, 0.001 to 60 mass%, 0.001 to 50 mass%; 0.01 to 90 mass%, 0.01 to 80 mass%, 0.01 to 70 mass%, 0.01 to 60 mass%, 0.01 to 50 mass%; 0.1 to 90 mass%, 0.1 to 80 mass%, 0.1 to 70 mass%, 0.1 to 60 mass%, 0.1 to 50 mass%; 1 to 90 mass%, 1 to 80 mass%, 1 to 70 mass%, 1 to 60 mass%, 1 to 50 mass%; 5-90 mass%, 5-80 mass%, 5-70 mass%, 5-60 mass%, 5-50 mass%; 10-90 mass%, 10-80 mass%, 10-70 mass%, 10-60 mass%, 10-50 mass%; 20-90 mass%, 20-80 mass%, 20-70 mass%, 2 0 to 60 mass%, 20 to 50 mass%; 30 to 90 mass%, 30 to 80 mass%, 30 to 70 mass%,
• the content of water may be at least 0.001 part by weight, at least 0.01 part by weight, at least 0.05 part by weight, at least 0.1 part by weight, at least 1 part by weight, at least 5 parts by weight, at least 10 parts by weight, at least 30 parts by weight, at least 50 parts by weight, or at least 80 parts by weight per part by weight of the polar base.
• the formulation will suppress irritation to the oral mucosa caused by the polar base and will exhibit a sufficient denture adhesive removal effect.
• the water content may be 95 parts by weight or less, 90 parts by weight or less, 80 parts by weight or less, 70 parts by weight or less, 60 parts by weight or less, 50 parts by weight or less, 30 parts by weight or less, 10 parts by weight or less, 5 parts by weight or less, or 3 parts by weight or less per part by weight of the polar base.
• sufficient amounts of metal compound and polar base can be blended, resulting in a formulation that can fully exhibit the denture adhesive removal effect.
• the ratio of water content to 1 part by mass of polar base is 0.001 to 95 parts by mass, 0.001 to 90 parts by mass, 0.001 to 80 parts by mass, 0.001 to 70 parts by mass, 0.001 to 60 parts by mass, 0.001 to 50 parts by mass, 0.001 to 30 parts by mass, 0.001 to 10 parts by mass, 0.001 to 5 parts by mass, 0.001 to 3 parts by mass; 0.01 to 95 parts by mass, 0.01 to 90 parts by mass, 0.01 to 80 parts by mass, 0.01 to 70 parts by mass, 0.01 to 60 Parts by mass, 0.01 to 50 parts by mass, 0.01 to 30 parts by mass, 0.01 to 10 parts by mass, 0.01 to 5 parts by mass, 0.01 to 3 parts by mass; 0.05 to 95 parts by mass, 0.05 to 90 parts by mass, 0.05 to 80 parts by mass, 0.05 to 70 parts by mass parts by weight, 0.05 to 60 parts by weight, 0.05 to 50 parts by weight, 0.05 to 30 parts by weight, 0.05 to 10 parts by weight,
• the remover of the present invention does not contain water, it can be prepared at the time of use so that it contains water at the above concentration or content.
• the denture adhesive remover of the present invention may contain additives depending on the formulation, provided that the effects of the present invention are not impaired.
• additives include surfactants, pH adjusters, bactericidal components or preservatives, humectants, stabilizers, thickeners, sweeteners, and flavorings.
• One or more additives may be used.
• surfactant anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants, naturally occurring surfactants, organic solvents that function as solubilizers, and the like can be used.
• the cleaning effect of surfactants can emulsify hydrophobic ointment base components such as liquid paraffin and white petrolatum contained in denture adhesives, further increasing the efficiency of removing the denture adhesive.
• anionic surfactants include higher alkyl sulfates such as sodium lauryl sulfate and potassium lauryl sulfate; alkyl ether sulfates such as POE-triethanolamine lauryl sulfate and sodium POE-lauryl sulfate; higher fatty acid amide sulfonates such as sodium stearoyl methyl taurate, sodium myristoyl methyl taurate, sodium cocoyl methyl taurate and sodium cocoyl methyl taurate; POE-alkyl ether phosphates and salts thereof such as sodium POE-oleyl ether phosphate, sodium POE-cetyl ether phosphate and POE-stearyl ether phosphate; phosphate esters and salts thereof such as potassium cetyl phosphate and cetyl phosphate; sulfosuccinates such as sodium di-2-ethylhexyl sulfosuccinate; alkyl benzene s
• Cationic surfactants include fatty acid amidoamines such as stearamidopropyl dimethylamine and behenamidopropyl dimethylamine; monoalkyl quaternary ammonium salts such as cetrimonium chloride, steartrimonium chloride, behentrimonium chloride, steartrimonium bromide, cetrimonium methosulfate and behentrimonium methosulfate; and monoalkyl ether quaternary ammonium salts such as stearoxypropyltrimonium chloride and behenyl PG trimonium chloride.
• monoalkyl quaternary ammonium salts such as cetrimonium chloride, steartrimonium chloride, behentrimonium chloride, steartrimonium bromide, cetrimonium methosulfate and behentrimonium methosulfate
• monoalkyl ether quaternary ammonium salts such as stearoxypropyl
• dialkyl quaternary ammonium salts such as distearyldimonium chloride, dicocodimonium chloride, dialkyl (12-18 carbon atoms) dimonium chloride, and quaternium-18; dialkyl ester quaternary ammonium salts such as dicocoyl ethyl hydroxyethylmonium methosulfate and distearoyl ethyl hydroxyethylmonium methosulfate; and benzalkonium quaternary ammonium salts such as benzalkonium chloride and benzethonium chloride.
• Amphoteric surfactants include carbobetaine, sulfobetaine, imidazolinium betaine, and amidobetaine.
• Nonionic surfactants include POE-2-decyltetradecyl alcohol, POE-alkyl ethers such as polyoxyethylene oleyl ether and polyoxyethylene cetyl ether; sorbitan fatty acid esters such as sorbitan monostearate, sorbitan sesquistearate, sorbitan tristearate, sorbitan monooleate, and sorbitan sesquioleate; POE (20) sorbitan monoisostearate, POE (20) sorbitan monooleate, POE (20) sorbitan monostearate, and POE (20) sorbitan monococonut oil fatty acid esters.
• POE-2-decyltetradecyl alcohol POE-alkyl ethers such as polyoxyethylene oleyl ether and polyoxyethylene cetyl ether
• sorbitan fatty acid esters such as sorbitan monostearate, sorbitan sesquistearate, sorbitan triste
• POE-sorbitan fatty acid esters such as sorbitan and POE (80) sorbitan laurate; glycerin fatty acid esters such as glyceryl monostearate and glyceryl oleate; POE-glycerin fatty acid esters such as polyoxyethylene glyceryl stearate and polyoxyethylene glyceryl trioleate; POE-dihydrocholesterol esters; polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), polyoxyethylene hydrogenated castor oil 50 (HCO-60), polyoxyethylene hydrogenated castor oil 50 (HCO-5 ...
• POE-hydrogenated castor oils such as ethylenedioxy hydrogenated castor oil 80; POE castor oils such as POE (3) castor oil and POE (20) castor oil; POE-hydrogenated castor oil fatty acid esters such as POE-hydrogenated castor oil isostearate; POE-alkylaryl ethers; glycerin alkyl ethers such as cumyl alcohol, batyl alcohol, and selachyl alcohol; POE-glycerin alkyl ethers such as POE-monostearyl glyceryl ether; POE fatty acid esters such as polyoxyl stearate; sucrose palmitate, sucrose stearate Examples include sucrose fatty acid esters such as phosphate esters, sucrose oleate, sucrose isostearate, sucrose linoleate, and sucrose linolenate; polyethylene glycol fatty acid esters such as polyethylene glycol dioleate; and polyglycerin fatty
• Naturally derived surfactants include lecithin, hydrogenated lecithin, saponin, sodium surfactin, and bile acids.
• organic solvents examples include POE/POP alkyl ethers (where the alkyl group has 10 to 26 carbon atoms) (POE/POP cetyl ethers such as POE(20)POP(4) cetyl ether, POE/POP decyltetradecyl ethers such as POE(30)POP(6) decyltetradecyl ether, POE/POP decyltetradecyl ethers such as POE(20)POP(6) decyltetradecyl ether); POE alkyl ethers (where the alkyl group has 10 to 26 carbon atoms) (POE oleyl ethers such as POE(50) oleyl ether, POE oleyl ethers such as POE(20) oleyl ether, POE lauryl ethers such as POE(25) lauryl ether); and solubilizers such as lauromacrogol.
• the surfactant concentration can be at least 0.01%, 0.1%, 1%, 3%, 5%, or 10% by weight of the total amount of the remover. Within this range, denture adhesive can be removed more effectively. Furthermore, when the remover of the present invention contains a surfactant, its concentration can be 20% by weight or less, 10% by weight or less, 8% by weight or less, 6% by weight or less, or 4% by weight or less, based on the total amount of the remover.
• an excessive amount of surfactant can actually reduce the cleaning effect of the preparation, but within this range, the cleaning effect of the preparation is not reduced, and sufficient amounts of metal compound and polar base can be incorporated, resulting in a preparation that can fully demonstrate its denture adhesive removing effect.
• the concentration of the surfactant relative to the total amount of the remover can be 0.01 to 20% by mass, 0.01 to 10% by mass, 0.01 to 8% by mass, 0.01 to 6% by mass, 0.01 to 4% by mass; 0.1 to 20% by mass, 0.1 to 10% by mass, 0.1 to 8% by mass, 0.1 to 6% by mass, 0.1 to 4% by mass; 1 to 20% by mass, 1 to 10% by mass, 1 to 8% by mass, 1 to 6% by mass, 1 to 4% by mass; 3 to 20% by mass, 3 to 10% by mass, 3 to 8% by mass, 3 to 6% by mass, 3 to 4% by mass; 5 to 20% by mass, 5 to 10% by mass, 5 to 8% by mass, 5 to 6% by mass; and 10 to 20% by mass.
• the content thereof can be at least 0.001 parts by weight, at least 0.005 parts by weight, at least 0.01 parts by weight, at least 0.05 parts by weight, at least 0.1 parts by weight, at least 1 part by weight, at least 5 parts by weight, or at least 10 parts by weight per part by weight of the polar base.
• the content of the surfactant can be 40 parts by weight or less, 30 parts by weight or less, 25 parts by weight or less, 20 parts by weight or less, 10 parts by weight or less, 5 parts by weight or less, 1 part by weight or less, or 0.5 parts by weight or less per part by weight of the polar base.
• an excessive amount of surfactant can actually reduce the cleaning effect of the preparation, but if the content is within this range, the cleaning effect of the preparation will not be reduced and sufficient amounts of metal compound and polar base can be incorporated, resulting in a preparation that can fully exhibit the denture adhesive removal effect.
• the ratio of surfactant content to 1 part by mass of polar base is 0.001 to 40 parts by mass, 0.001 to 30 parts by mass, 0.001 to 25 parts by mass, 0.001 to 20 parts by mass, 0.001 to 10 parts by mass, 0.001 to 5 parts by mass, 0.001 to 1 part by mass, 0.001 to 0.5 parts by mass; 0.005 to 40 parts by mass, 0.005 to 30 parts by mass, 0.
• the content thereof can be at least 0.01 part by weight, at least 0.05 part by weight, at least 0.1 part by weight, at least 0.15 part by weight, at least 0.5 part by weight, at least 0.8 part by weight, or at least 1 part by weight per part by weight of the metal compound.
• denture adhesive can be effectively removed.
• the surfactant content can be 20 parts by mass or less, 10 parts by mass or less, 5 parts by mass or less, or 3 parts by mass or less per part by mass of the metal compound.
• an excessive amount of surfactant can actually reduce the cleaning effect of the preparation, but within this range, the cleaning effect of the preparation is not reduced, and sufficient amounts of metal compound and polar base can be incorporated, resulting in a preparation that can fully demonstrate its denture adhesive removal effect.
• the ratio of surfactant content to 1 part by mass of metal compound is 0.01 to 20 parts by mass, 0.01 to 10 parts by mass, 0.01 to 5 parts by mass, 0.01 to 3 parts by mass; 0.05 to 20 parts by mass, 0.05 to 10 parts by mass, 0.05 to 5 parts by mass, 0.05 to 3 parts by mass; 0.1 to 20 parts by mass, 0.1 to 10 parts by mass, 0.1 to 5 parts by mass, 0.1 to 3 parts by mass; 0.15-20 parts by mass, 0.15-10 parts by mass, 0.15-5 parts by mass, 0.15-3 parts by mass; 0.5-20 parts by mass, 0.5-10 parts by mass, 0.5-5 parts by mass, 0.5-3 parts by mass Parts: 0.8 to 20 parts by weight, 0.8 to 10 parts by weight, 0.8 to 5 parts by weight, 0.8 to 3 parts by weight; 1 to 20 parts by weight, 1 to 10 parts by weight, 1 to 5 parts by weight, and 1 to 3 parts by weight.
• pH adjusters include organic acids and their salts such as acetic acid, oxalic acid, maleic acid, fumaric acid, malonic acid, lactic acid, tartaric acid, citric acid, benzoic acid, methanesulfonic acid, succinic acid, malic acid, ascorbic acid, adipic acid, and benzoic acid; inorganic acids and their salts such as phosphoric acid, hydrochloric acid, nitric acid, and carbonic acid; inorganic bases such as potassium hydroxide and sodium hydroxide; and organic bases such as triethanolamine, diisopropanolamine, and triisopropanolamine.
• organic acids and their salts such as acetic acid, oxalic acid, maleic acid, fumaric acid, malonic acid, lactic acid, tartaric acid, citric acid, benzoic acid, methanesulfonic acid, succinic acid, malic acid, ascorbic acid, adipic acid, and benzoic acid
• antiseptic ingredients or preservatives include glycerin fatty acid esters; parabens such as isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, methyl parahydroxybenzoate, sodium methyl parahydroxybenzoate, ethyl parahydroxybenzoate, sodium ethyl parahydroxybenzoate, butyl parahydroxybenzoate, propyl parahydroxybenzoate, and sodium propyl parahydroxybenzoate; benzoic acids such as benzoic acid, sodium benzoate, and benzyl benzoate; quaternary ammonium salts such as benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, cetylpyridinium chloride, tetraethylammonium bromide, and didecyldimethylammonium chloride; ethylenediaminetetraacetate; chlorhexidine salts such as chlorhexidine gluconate and chlorhexidine
• Humectants include glycerin and sorbitol.
• Stabilizers include sodium polyacrylate, dibutylhydroxytoluene, and butylhydroxyanisole.
• Thickeners include guar gum, locust bean gum, carrageenan, xanthan gum, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, acrylate/alkyl methacrylate copolymer, polyethylene glycol, bentonite, alginic acid, macrogol, and cellulose-based thickeners (methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, carboxyethylcellulose, etc.).
• Sweeteners include saccharin sodium, stevia extract, sucralose, palatinose, maltitol, xylitol, trehalose, and arabitol.
• Flavors include various essential oils, essential oil components such as menthol, and compound fragrances.
• the remover of the present invention can be in the form of a solid such as a powder, tablet, or gum, a liquid (including a viscous fluid form), or a paste. Furthermore, a liquid or paste preparation can be impregnated into a nonwoven fabric or the like to form a sheet.
• a gum, paste, or sheet When used as a remover for the oral cavity, as described below, it is preferable to use a gum, paste, or sheet to prevent aspiration in elderly people.
• Dry solid preparations such as powders and tablets can be prepared as ready-to-use preparations that are mixed with water, etc., at the time of use.
• the composition of the remover of the present invention described above is the composition of the finished preparation that is mixed with water, etc., at the time of use.
• the remover of the present invention can be a denture adhesive remover for removing denture adhesive from dentures. It can also be a denture adhesive remover for removing denture adhesive from the oral cavity (oral mucosa), i.e., an oral denture adhesive remover. Denture adhesive removers are also sometimes called denture adhesive cleaners.
• the amount of the remover of the present invention used can be 1.5 to 15 g, preferably 2 to 10 g, per 1 g of denture adhesive.
• the denture adhesive can be removed from the denture and oral cavity by, for example, moving the denture adhesive with your hands or rubbing it with your fingers, a brush, or a cloth. If the remover of the present invention is left to stand for up to 60 seconds, preferably 5 to 10 seconds, after applying it to the denture adhesive, the adhesive strength of the denture adhesive will be more effectively reduced, making it easier to remove.
• the present invention encompasses a method for removing a denture adhesive (e.g., a method for removing a denture adhesive from a denture or oral cavity) comprising applying to the denture adhesive a composition comprising a polar base and at least one metal compound.
• the metal compound is (1) A salt of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron and at least one compound selected from the group consisting of an inorganic acid, an organic acid, and ammonia, or a hydrate thereof; (2) an oxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof; and (3) a hydroxide of at least one metal selected from the group consisting of sodium, potassium, calcium, magnesium, aluminum, zinc, and iron, or a hydrate thereof.
• the metal compound may contain two or more kinds of metals and may also contain two or more kinds of counter ions of the metal ions, for example, salts of the above metals with organic or inorganic acids and ammonia.
• the denture adhesive can be attached to the denture or the oral cavity.
• the composition and properties of the composition containing the polar base and the metal compound are as described above for the denture adhesive remover of the present invention.
• the amount of the composition containing a polar base and at least one metal compound used should be an effective amount, preferably 1.5 to 15 g, and more preferably 2 to 10 g, per 1 g of denture adhesive.
• the remover of the present invention can be applied to the denture adhesive by coating, spraying, or pasting.
• a step of allowing the applied denture adhesive to stand can be included, which can be for up to 60 seconds, and more preferably 5 to 10 seconds. Furthermore, a step of applying force to the denture adhesive to remove it from the denture or oral cavity can be included.
• Denture adhesive remover performance evaluation No. 1 The performance of denture adhesive removers was evaluated by simulating the conditions of dentures and the oral cavity. 0.1 g of denture adhesive (product name: Additive-Free New Polygrip) was applied to a 70 x 70 mm, 2 mm thick glass plate and immersed in tap water. After 1 minute, the plate was removed, and another glass plate of the same size was placed over the denture adhesive. A 1 kg weight was then placed on top of the plate to apply a load. After 10 seconds, the weight was removed, and one of the glass plates was peeled off to obtain a specimen. 1 g of each formulation from the Examples or Comparative Examples was applied to the denture adhesive and its surrounding area.
• the denture adhesive was rubbed with a finger and the state of release was scored on a 5-point scale according to the following criteria. A score of 2 or higher was considered "pass," indicating sufficiently effective and efficient removal. 0: Cannot be removed at all 1: When force is applied, the surface layer of the denture adhesive moves, but it cannot be peeled off 2: The surface layer of the denture adhesive moves with light force, and when strong force is applied, it can be almost completely peeled off 3: When strong force is applied, it can be completely peeled off 4: It can be completely peeled off with light force
• the remover of the present invention acts on denture adhesive, changing its physical properties and thereby promoting its release, so it is reasonably expected that if it can be removed from a glass plate, it can also be removed from the oral cavity. Furthermore, some of the example formulations have an irritating or unpleasant taste and are therefore unsuitable for removing denture adhesive from the oral cavity, but are useful for removing denture adhesive from dentures.
• Denture adhesive remover performance evaluation No. 2 The denture adhesive removal performance in the human oral cavity was evaluated for the formulations of Examples and Comparative Examples that were judged to be suitable for use in the oral cavity from the standpoint of irritation, taste, etc. (Examples and Comparative Examples with irritation to the oral mucosa and unpleasant taste rated as ⁇ or ⁇ in Tables 1 to 7).
• 0.2 g of denture adhesive (product name: Additive-free New Polygrip) colored with Blue No. 1 was applied to the palate of one subject, and a splint made to fit the subject's palate was placed over it.
• Figure 2 also shows the condition of the oral cavity before and after wiping with the preparation of Comparative Example 2.
• the adhesiveness of the denture adhesive was not reduced, and it was not sufficiently removed by wiping for 30 seconds, leaving a thin layer of denture adhesive remaining in the oral cavity.
• the remover of the present invention uses a polar base and metal compound to chemically reduce the adhesiveness of denture adhesive, allowing it to effectively and efficiently remove denture adhesive from the oral cavity and dentures. Furthermore, because it can be prepared using general-purpose ingredients that are suitable for use in the oral cavity and have little irritation or unpleasant taste, it can be used in a wide range of fields, including dental care and nursing care, making it highly valuable as a product.

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• 2024
  • 2024-09-25 JP JP2024557438A patent/JPWO2025163966A1/ja active Pending
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