JP7372650B2 - 液体口腔用組成物 - Google Patents
液体口腔用組成物 Download PDFInfo
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- JP7372650B2 JP7372650B2 JP2019147434A JP2019147434A JP7372650B2 JP 7372650 B2 JP7372650 B2 JP 7372650B2 JP 2019147434 A JP2019147434 A JP 2019147434A JP 2019147434 A JP2019147434 A JP 2019147434A JP 7372650 B2 JP7372650 B2 JP 7372650B2
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- 239000000203 mixture Substances 0.000 title description 30
- 239000007788 liquid Substances 0.000 title description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 9
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 9
- 239000002324 mouth wash Substances 0.000 claims description 9
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 7
- 239000004359 castor oil Substances 0.000 claims description 7
- 235000019438 castor oil Nutrition 0.000 claims description 7
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 7
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 claims description 7
- 229960000401 tranexamic acid Drugs 0.000 claims description 7
- -1 Polyoxyethylene Polymers 0.000 claims description 6
- 239000004615 ingredient Substances 0.000 claims description 6
- 239000000230 xanthan gum Substances 0.000 claims description 6
- 229920001285 xanthan gum Polymers 0.000 claims description 6
- 235000010493 xanthan gum Nutrition 0.000 claims description 6
- 229940082509 xanthan gum Drugs 0.000 claims description 6
- 229940051866 mouthwash Drugs 0.000 claims description 5
- 210000000214 mouth Anatomy 0.000 description 26
- 230000003020 moisturizing effect Effects 0.000 description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 239000003899 bactericide agent Substances 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 4
- 230000008719 thickening Effects 0.000 description 4
- 125000002091 cationic group Chemical group 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 229940012957 plasmin Drugs 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000035807 sensation Effects 0.000 description 3
- 235000019615 sensations Nutrition 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 239000000606 toothpaste Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 235000019658 bitter taste Nutrition 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000002845 discoloration Methods 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
- 229960002216 methylparaben Drugs 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 235000010724 Wisteria floribunda Nutrition 0.000 description 1
- 241000589636 Xanthomonas campestris Species 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000011086 high cleaning Methods 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000000213 tara gum Substances 0.000 description 1
- 235000010491 tara gum Nutrition 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
なお、上記粘度は、Anton Paar社製のレオメータ(機種Physica MCR 301)を用いて測定し、試料温度20℃、コーンプレート 50-1、せん断速度1.0(1/s)のせん断粘度の値を示した。
専門パネラー10名が表に示したサンプルの液体口腔用組成物を約10mL口に含み、30秒間すすいだ後、洗口時の(1)適度なとろみ感、(2)口の中でのすすぎやすさ、また、洗口後の(3)保湿感について以下の基準に従って評価した。
(評価基準)
3点:適度なとろみ感を感じる
2点:とろみ感をほとんど感じない又はとろみ感がやや強い
1点:とろみ感を感じない又はとろみ感が強すぎる
(判定基準)
◎:平均点が2.5点以上3.0点以下
○:平均点が2.0点以上2.5点未満
×:平均点が2.0点未満
(評価基準)
4点:とてもすすぎやすい
3点:すすぎやすい
2点:ややすすぎにくい
1点:すすぎにくい
(判定基準)
◎:平均点が3.5点以上4.0点以下
○:平均点が3.0点以上3.5点未満
△:平均点が2.0点以上3.0点未満
×:平均点が2.0点未満
(評価基準)
4点:とてもうるおいを感じる
3点:うるおいを感じる
2点:ややうるおいを感じる
1点:うるおいを感じない
(判定基準)
◎:平均点が3.5点以上4.0点以下
○:平均点が3.0点以上3.5点未満
△:平均点が2.0点以上3.0点未満
×:平均点が2.0点未満
表に示した各サンプルの外観透明性を目視にて観察し、以下の基準に従って評価した。評価は無色透明な水を基準とした。
(判定基準)
○:濁りや変色がなく、無色透明である
×:明らかに濁りや変色が見られる
・塩化セチルピリジニウム(富士フィルム和光純薬社製)
・トラネキサム酸(協和ファーマケミカル社製)
・キサンタンガム(三晶社製)
・ポリオキシエチレン硬化ヒマシ油(60EO)、ポリオキシエチレン硬化ヒマシ油(40EO)(日光ケミカルズ社製)
(成分) (重量%)
1.塩化セチルピリジニウム 0.04
2.トラネキサム酸 0.03
3.キサンタンガム 0.07
4.ポリオキシエチレン硬化ヒマシ油(40EO) 2.0
5.グリセリン 4.0
6.プロピレングリコール 4.0
7.キシリトール 3.0
8.クエン酸 0.03
9.クエン酸ナトリウム 0.27
10.香料 0.1
11.メチルパラベン 0.1
12.精製水 残余
(調製方法)
実施例1~8と同様の方法で調製した。
粘度 50mPa・s/20℃
(成分) (重量%)
1.塩化セチルピリジニウム 0.06
2.トラネキサム酸 0.04
3.キサンタンガム 0.1
4.ポリオキシエチレン硬化ヒマシ油(60EO) 2.5
5.グリセリン 7.0
6.プロピレングリコール 4.0
7.ソルビトール 5.0
8.リン酸一水素ナトリウム 0.05
9.リン酸二水素ナトリウム 0.25
10.香料 0.15
11.メチルパラベン 0.1
12.精製水 残余
(調製方法)
実施例1~8と同様の方法で調製した。
粘度 200mPa・s/20℃
Claims (1)
- 次の成分(A)~(D);
(A)塩化セチルピリジニウム 0.01~0.1重量%
(B)トラネキサム酸 0.01~0.1重量%
(C)キサンタンガム 0.02~0.2重量%
(D)ポリオキシエチレン硬化ヒマシ油 1~3重量%
を含有し、かつ20℃における粘度が10~800mPa・sであることを特徴とするエタノールを含有しない洗口液。
Priority Applications (1)
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JP2019147434A JP7372650B2 (ja) | 2019-08-09 | 2019-08-09 | 液体口腔用組成物 |
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JP2019147434A JP7372650B2 (ja) | 2019-08-09 | 2019-08-09 | 液体口腔用組成物 |
Publications (2)
Publication Number | Publication Date |
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JP2021028302A JP2021028302A (ja) | 2021-02-25 |
JP7372650B2 true JP7372650B2 (ja) | 2023-11-01 |
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JP2019147434A Active JP7372650B2 (ja) | 2019-08-09 | 2019-08-09 | 液体口腔用組成物 |
Country Status (1)
Country | Link |
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JP (1) | JP7372650B2 (ja) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012046433A (ja) | 2010-08-25 | 2012-03-08 | Kao Corp | 液体口腔用組成物 |
JP2018048098A (ja) | 2016-09-23 | 2018-03-29 | 小林製薬株式会社 | 口腔用又は外用組成物 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09295923A (ja) * | 1996-04-30 | 1997-11-18 | Lion Corp | 泡状口腔用組成物 |
-
2019
- 2019-08-09 JP JP2019147434A patent/JP7372650B2/ja active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2012046433A (ja) | 2010-08-25 | 2012-03-08 | Kao Corp | 液体口腔用組成物 |
JP2018048098A (ja) | 2016-09-23 | 2018-03-29 | 小林製薬株式会社 | 口腔用又は外用組成物 |
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