Classifications

• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
  • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
  • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode

Definitions

• the technology disclosed herein relates to an analysis result display processing device, an analysis result display processing method, and an analysis result display processing program.
• chromatograph mass spectrometers such as gas chromatography-mass spectrometers (GC-MS) or liquid chromatography-mass spectrometers (LC-MS) have been widely used in various fields, such as testing for residual pesticides in food, testing for pollutants in environmental water, and metabolomics analysis of biological samples.
• GC-MS gas chromatography-mass spectrometers
• LC-MS liquid chromatography-mass spectrometers
• the pattern of the measured mass spectrum at the retention time near the peak top of a peak detected in a total ion current chromatogram is generally compared with that of a standard mass spectrum recorded in a mass spectrum library, and the compound is identified by determining whether the similarity is equal to or exceeds a predetermined threshold or shows a high value (see International Publication No. 2018/138901).
• This method is called non-targeted analysis because the compound to be analyzed is not specified in advance. Non-targeted analysis is effective when performing a comprehensive search for compounds.
• peaks can be detected from the extracted ion chromatogram (also commonly referred to as "mass chromatogram") at the m/z value of the monitor ion. Therefore, even if the peak is small and is buried in adjacent peaks on the TICC, the peak can be detected accurately and efficiently to identify the compound (see "GC/MS Forensic Toxicology Database Ver. 2", [Online], [Searched on November 30, 2021], Shimadzu Corporation, Internet ⁇ URL: https://www.an.shimadzu.co.jp/gcms/dpd.htm>).
• the second aspect is an analysis result display processing method of the analysis result display processing device of the first aspect, comprising the steps of: the reception processing unit receiving a designation of a second number of compounds smaller than the first number selected from the first number of compounds; and the display processing unit processing so that the analysis result of the presence or absence of the second number of compounds extracted from the analysis results of the presence or absence of the first number of compounds stored in the storage device is displayed on the display device.
• the analysis result display processing program of the third aspect causes a computer to function as the reception processing unit and the display processing unit of the first aspect.
• the analysis result display processing program of the sixth aspect causes a computer to function as the analysis processing unit, the reception processing unit, and the display processing unit of the fourth aspect.
• the technology disclosed herein can provide analysis results regarding the presence or absence of a second number of compounds that is smaller than the first number that the user wishes to check, from among a first number of compounds, in a shorter time than conventional technology.
• FIG. 1 is a graph showing a total ion chromatogram.
• FIG. 1 is a conceptual diagram illustrating an example of a first number of analytical methods for determining the presence or absence of a first number of compounds in a sample.
• FIG. 13 is a conceptual diagram illustrating an example of an analysis method for a second number that is less than a first number.
• FIG. 13 is a conceptual diagram showing an example of a display screen displaying a graph of the analysis results of the presence or absence of a specified compound among a second number of compounds, data of the analysis results of the presence or absence of a specified compound among a second number of compounds, and the second number of analysis methods.
• FIG. 13 is a conceptual diagram showing an example of a remaining analysis method other than the second number among the first number.
• FIG. 1 is a conceptual diagram illustrating an example of a first number of analytical methods for determining the presence or absence of a first number of compounds in a sample.
• FIG. 13 is a conceptual diagram illustrating an example of an analysis
• 13 is a conceptual diagram showing an example of a display screen displaying a graph of the analysis results of the presence or absence of remaining compounds other than the second number in the first number, data of the analysis results of the remaining compounds, and a method file of the analysis method for the remaining number. 13 is a flowchart illustrating an example of the flow of an analysis result display process according to the second embodiment.
• FIG. 1 is a block diagram showing an example of the hardware configuration and main functions of an electrical system of an analysis result display processing system according to a first embodiment.
• the analysis result display processing system includes a gas chromatograph mass spectrometer 1 and an analysis result display process 20.
• the gas chromatograph mass spectrometer 1 is an example of the "combination of a chromatograph and a mass spectrometer" of the technology disclosed herein.
• the analysis results of the first number of compounds were displayed one by one in a predetermined order, so it took a long time before the results of the presence or absence of the compound that the user wanted to check were displayed.
• the analysis results of the presence or absence of only the second number of compounds out of the first number for the sample are displayed, and the user can know the analysis results of the presence or absence of each compound in a shorter time than with the conventional technology.
• the analysis results of the presence or absence of the second number of compounds that is smaller than the first number that the user wants to check from the first number of compounds can be provided in a shorter time than with the conventional technology.
• the mass spectrometer 1B performs a total ion monitoring method (TIM) (so-called scan measurement), but the technology of the present disclosure is not limited to this.
• TIM total ion monitoring method
• SIM Select Ion Monitoring
• SRM Select Reaction Monitoring
• MRM Multiple Reaction Monitoring
• the hardware structure of these various processors can be an electric circuit that combines circuit elements such as semiconductor elements.
• the above analysis result display process is merely one example. It goes without saying that unnecessary steps can be deleted, new steps can be added, and the processing order can be changed without departing from the spirit of the invention.
• the analysis result display processing device of paragraph 2 makes it easy to select identification information.
• (Section 3) The analysis result display processing device according to claim 1, wherein when the reception processing unit receives a specification of at least one remaining compound other than the second number of compounds among the first number of compounds, the display processing unit processes the analysis result of the specified compound to be displayed on the display device.
• the analysis result display processing device of paragraph 3 can also display the analysis result of at least one remaining compound other than the second number of compounds among the first number of compounds.
• the analysis result display processing device of paragraph 4 allows the identification information to be easily selected.
• the display device displays the identification information of the compound in a corresponding manner to a selection field, When the selection field is selected, the reception processing unit regards the identification information corresponding to the selection field as being selected and receives the designation of the compound.
• the analysis result display processing device according to claim 2 or 4.
• the analysis result display processing device of paragraph 5 allows the identification information to be easily selected.
• the analysis result display processing device of paragraph 8 makes it easy to select identification information.
• an analysis result display processing method for the analysis result display processing device receives a designation of a second number of compounds selected from the first number of compounds, the second number being smaller than the first number; the display processing unit processes the analysis result of the presence or absence of the second number of compounds extracted from the analysis result of the presence or absence of the first number of compounds stored in the storage device so as to display on a display device;
• the analysis result display processing method includes:
• the analysis result of the presence or absence of a second number of compounds that is smaller than the first number that the user wants to check among a first number of compounds can be provided in a shorter time than with the conventional technology.
• (Article 11) a storage device that stores a chromatogram obtained by performing an analysis on a sample using an apparatus that combines a chromatograph and a mass spectrometer; an analysis processing unit capable of analyzing the presence or absence of a first number of compounds in the sample by using the mass spectrum and a first number of analysis methods for confirming the presence or absence of the first number of compounds; a display processing unit that processes the analysis result so that it is displayed on a display device;
• An analysis result display processing device comprising: A reception processing unit that receives a designation of a compound, the analysis processing unit, when the reception processing unit receives a designation of a second number of compounds selected from the first number of compounds and smaller than the first number, performs an analysis of the presence or absence of the second number of compounds; The display processing unit processes the analysis result of the presence or absence of the second number of compounds so as to be displayed on the display device. Analysis result display processing device.
• the display device displays identification information of each of the first number of compounds; the reception processing unit receives, when identification information of the second number of compounds is selected from the identification information of the first number of compounds displayed on the display device, designation of the second number of compounds.
• the analysis result display processing device according to claim 11.
• the analysis result display processing device of paragraph 12 allows the identification information to be easily selected.
• the analysis processing unit when the reception processing unit receives a designation of at least one remaining compound other than the second number of compounds among the first number of compounds, the analysis processing unit performs an analysis of whether or not the designated compound is to be analyzed;
• the display processing unit processes the analysis result of the presence or absence of the specified compound so as to be displayed on the display device.
• the analysis result display processing device according to claim 11 or 12.
• the analysis result display processing device of paragraph 13 can also display the analysis result of at least one remaining compound other than the second number of compounds among the first number of compounds.
• the display device displays the identification information of the compound in a corresponding manner to a selection field, When the selection field is selected, the reception processing unit regards the identification information corresponding to the selection field as being selected and receives the designation of the compound.
• the analysis result display processing device according to claim 12 or 14.
• the identification information can be easily selected.
• the selection field is a radio button or a check box.
• the analysis result display processing device of paragraph 16 makes it easy to select identification information.
• the analysis result display processing device of paragraph 18 allows the identification information to be easily selected.
• an analysis result display processing method for an analysis result display processing device the analysis processing unit, when the reception processing unit receives a designation of a second number of compounds selected from the first number of compounds and smaller than the first number, performs an analysis of the presence or absence of the second number of compounds; the display processing unit processes the analysis result of the presence or absence of the second number of compounds to be displayed on the display device;
• the analysis result display processing method includes:
• the analysis result of the presence or absence of a second number of compounds that is smaller than the first number that the user wants to check among a first number of compounds can be provided in a shorter time than with the conventional technology.
• the analysis result of the presence or absence of a second number of compounds that is smaller than the first number that the user wants to check among a first number of compounds can be provided in a shorter time than the conventional technology.

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• Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

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Citations (7)

• 2023
  • 2023-01-06 JP JP2024568678A patent/JPWO2024147191A1/ja active Pending
  • 2023-01-06 WO PCT/JP2023/000135 patent/WO2024147191A1/ja not_active Ceased

Patent Citations (7)

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