WO2024142684A1 - 創傷被覆材用粘着剤および創傷被覆材 - Google Patents

創傷被覆材用粘着剤および創傷被覆材 Download PDF

Info

Publication number
WO2024142684A1
WO2024142684A1 PCT/JP2023/041937 JP2023041937W WO2024142684A1 WO 2024142684 A1 WO2024142684 A1 WO 2024142684A1 JP 2023041937 W JP2023041937 W JP 2023041937W WO 2024142684 A1 WO2024142684 A1 WO 2024142684A1
Authority
WO
WIPO (PCT)
Prior art keywords
adhesive
weight
surfactant
wound dressings
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2023/041937
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
孝晃 守屋
雅彦 橋本
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Moresco Corp
Original Assignee
Moresco Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Moresco Corp filed Critical Moresco Corp
Priority to JP2024567297A priority Critical patent/JPWO2024142684A1/ja
Publication of WO2024142684A1 publication Critical patent/WO2024142684A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/58—Adhesives
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J11/00—Features of adhesives not provided for in group C09J9/00, e.g. additives
    • C09J11/02—Non-macromolecular additives
    • C09J11/06—Non-macromolecular additives organic
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J11/00—Features of adhesives not provided for in group C09J9/00, e.g. additives
    • C09J11/08—Macromolecular additives
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J153/00—Adhesives based on block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Adhesives based on derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J201/00—Adhesives based on unspecified macromolecular compounds

Definitions

  • One aspect of the present invention aims to provide an adhesive for wound dressings that is both water absorbent and adheres well to the skin.
  • the present invention includes the following aspects.
  • An adhesive for wound dressings comprising a hot melt adhesive, a water absorbing material and a surfactant.
  • the HLB of the surfactant is 18 or less.
  • ⁇ 8> The adhesive for wound dressings according to ⁇ 7>, wherein the content of the cellulose compound in the water-absorbing substance is 70 to 100% by weight, assuming the weight of the water-absorbing substance to be 100% by weight.
  • a wound dressing comprising the adhesive for wound dressings according to any one of ⁇ 1> to ⁇ 8>.
  • FIG. 1 is a schematic diagram showing an example of a wound dressing according to one embodiment of the present invention. 1 is a schematic diagram showing an example of use of a wound dressing according to one embodiment of the present invention. FIG.
  • Hot melt adhesive is an adhesive that can be applied to a substrate by heating and melting it.
  • a hot melt adhesive usually contains a base polymer and a tackifier resin.
  • a hot melt adhesive may further contain a plasticizer and/or a wax as an optional component.
  • An adhesive may contain only one type of hot melt adhesive, or may contain two or more types.
  • Base polymer examples include styrene-based block copolymers, acrylic-based block copolymers, olefin-based polymers, polyester-based polymers, polyamide-based polymers, or combinations thereof.
  • styrene-based block copolymers, acrylic-based block copolymers, or combinations thereof, which are thermoplastic elastomers are preferably used.
  • acrylic block copolymers are more preferable because of their excellent moisture permeability.
  • the hot melt pressure-sensitive adhesive may contain only one type of base polymer, or may contain two or more types.
  • "elastomer” means a block copolymer that has rubber elasticity at room temperature.
  • styrene-based block copolymers include styrene-butadiene-styrene block copolymer (SBS), styrene-isoprene-styrene block copolymer (SIS), styrene-ethylene-butylene-styrene block copolymer (SEBS), and styrene-ethylene-propylene-styrene block copolymer (SEPS).
  • acrylic block copolymers include methyl methacrylate-n-butyl acrylate-methyl methacrylate block copolymer, and methyl methacrylate-2-ethylhexyl acrylate-methyl methacrylate block copolymer.
  • olefin-based polymers include homopolymers and copolymers of olefin monomers (ethylene, propylene, butene, etc.). More specific examples of olefin-based polymers include poly- ⁇ -olefins, amorphous poly- ⁇ -olefins (APAO), ethylene/ ⁇ -olefin copolymers, propylene/ ⁇ -olefin copolymers, ethylene-vinyl acetate copolymers, and ethylene-ethyl acrylate copolymers.
  • APAO amorphous poly- ⁇ -olefins
  • the lower limit of the content of the base polymer in the hot melt adhesive may be 25% by weight or more, 30% by weight or more, 35% by weight or more, or 39% by weight or more, based on 100% by weight of the hot melt adhesive.
  • the upper limit of the content of the base polymer in the hot melt adhesive may be 85% by weight or less, 80% by weight or less, 75% by weight or less, or 70% by weight or less, based on 100% by weight of the hot melt adhesive. If the content of the base polymer is within the above range, the adhesive for wound dressings will have improved adhesion to the skin.
  • the content of the elastomer in the base polymer is preferably 50% by weight or more, more preferably 80% by weight or more, and even more preferably 100% by weight.
  • Tackifier resin examples include a styrene-based resin, a rosin-based resin, a terpene-based resin, and a petroleum-based resin.
  • the hot melt pressure sensitive adhesive may contain only one type of tackifier resin, or may contain two or more types of tackifier resins.
  • rosin-based resins examples include natural rosins (such as gum rosin, tall rosin, and wood rosin), disproportionated rosin, polymerized rosin, glycerin esters of these rosins, and pentaerythritol esters of these rosins. Hydrogenated rosin-based resins (such as the hydrogenated products of the above-mentioned rosin-based resins) are also used.
  • terpene resins examples include terpene resins, hydrocarbon modified terpene resins, aromatic modified terpene resins, and phenolic modified terpene resins. Hydrogenated terpene resins (such as the hydrogenated terpene resins mentioned above) are also used.
  • Examples of petroleum-based resins include aliphatic petroleum resins, alicyclic petroleum resins, and aromatic petroleum resins. Hydrogenated petroleum-based resins (such as the hydrogenated versions of the above-mentioned petroleum-based resins) are also used.
  • styrene-based resins include polymers made of styrene-based monomers and copolymers of styrene-based monomers.
  • styrene-based monomers include styrene, methylstyrene, vinyltoluene, methoxystyrene, tertiary butylstyrene, and chlorostyrene. More specific examples of styrene-based resins include styrene homopolymer and ⁇ -methylstyrene homopolymer. Hydrogenated styrene-based resins (such as the hydrogenated styrene-based resins mentioned above) are also used.
  • plasticizer examples include oils. Examples of the oil include mineral oils, synthetic oils, vegetable oils, and fatty acid esters.
  • the hot melt pressure-sensitive adhesive may contain only one type of plasticizer, may contain two or more types of plasticizer, or may not contain any plasticizer.
  • fatty acid esters include isopropyl myristate, octyldodecyl myristate, glycerin triisooctanoate, diisopropyl adipate, diethyl sebacate, dibutyl sebacate, dioctyl sebacate, dodecyl sebacate, cetyl ethylhexanoate, cetyl palmitate, ethylhexyl palmitate, isopropyl palmitate, tributyl acetyl citrate, medium-chain fatty acid triglyceride, ethylene glycol salicylate, and glycol distearate.
  • the lower limit of the plasticizer content in the hot melt adhesive may be 0% by weight or more, 5% by weight or more, 7% by weight or more, or 10% by weight or more, with the weight of the hot melt adhesive being 100% by weight.
  • the upper limit of the plasticizer content in the hot melt adhesive may be 30% by weight or less, 25% by weight or less, 20% by weight or less, 15% by weight or less, or 10% by weight or less, with the weight of the hot melt adhesive being 100% by weight. If the plasticizer content is within the above range, the adhesiveness of the wound dressing adhesive to the skin is improved.
  • a hot melt adhesive composition that does not contain a plasticizer may be obtained by blending wax or the like instead of a plasticizer.
  • the water-absorbing material preferably contains a cellulose-based compound.
  • cellulose-based compounds include cellulose and cellulose derivatives. Of these, cellulose derivatives are preferred.
  • examples of cellulose derivatives include carboxyalkyl cellulose and hydroxyalkyl cellulose (the number of carbon atoms in the alkyl group is, for example, 1 to 4). More specific examples of cellulose derivatives include carboxymethyl cellulose, hydroxypropyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, and hydroxypropyl methyl cellulose.
  • the cellulose derivative may be in the form of a salt.
  • salts include sodium salts, potassium salts, calcium salts, and ammonium salts. More specific examples of cellulose derivatives in the form of a salt include sodium carboxymethyl cellulose, calcium carboxymethyl cellulose, potassium carboxymethyl cellulose, and ammonium carboxymethyl cellulose.
  • the cellulose compound is an ether-type cellulose derivative (such as sodium carboxymethylcellulose)
  • the lower limit of the degree of etherification of the hydroxyl group can be 0.1 or more, or 0.5 or more.
  • the upper limit of the degree of etherification can be 1.6 or less, or 1.0 or less.
  • the degree of etherification of the cellulose derivative is the average number of etherified hydroxyl groups per glucose unit, and takes a value between 0 and 3.
  • the degree of etherification of the cellulose derivative can be appropriately selected by a person skilled in the art in balance with other components contained in the adhesive for wound dressings.
  • the lower limit of the aqueous solution viscosity of the cellulose compound may be 5 mPa ⁇ s or more, or 50 mPa ⁇ s or more.
  • the upper limit of the viscosity of the cellulose compound may be 120,000 mPa ⁇ s or less, or 50,000 mPa ⁇ s or less.
  • the viscosity is measured under the conditions of a 1 wt% aqueous solution at 25°C.
  • the viscosity of the cellulose compound may be appropriately selected by a person skilled in the art, taking into account the balance with other components contained in the adhesive.
  • the adhesive layer 20 absorbs moisture and swells. This keeps the area around the wound A moist, accelerating the healing of the wound A.
  • the adhesive layer 20 contains an adhesive for wound dressings according to one embodiment of the present invention, so it can maintain adhesion to the skin while adequately absorbing exudates and other fluids from the wound A.
  • the evaluation criteria are as follows: A: 500% or more B: 350% or more, but less than 500% C: 300% or more, but less than 350% D: Less than 300%
  • the volumetric particle size distribution of the water-absorbing material was measured using LA-960V2 manufactured by Horiba, Ltd. The refractive index was set to 1.5. In the particle size distribution, the value at which the cumulative volume counted from the smallest particle size reached 50% was defined as D50 . In the particle size distribution, the value at which the cumulative volume counted from the smallest particle size reached 95% was defined as D95 .
  • an acrylic block copolymer or a styrene block copolymer was used to prepare the adhesive for wound dressing, it showed moisture permeability sufficient for practical use. However, since the acrylic block copolymer has higher moisture permeability than the styrene block copolymer, it is more preferable to use an acrylic block copolymer from the viewpoint of moisture permeability.
  • the present invention can be used for wound dressings, etc.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
PCT/JP2023/041937 2022-12-26 2023-11-22 創傷被覆材用粘着剤および創傷被覆材 Ceased WO2024142684A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024567297A JPWO2024142684A1 (https=) 2022-12-26 2023-11-22

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2022208995 2022-12-26
JP2022-208995 2022-12-26

Publications (1)

Publication Number Publication Date
WO2024142684A1 true WO2024142684A1 (ja) 2024-07-04

Family

ID=91717134

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2023/041937 Ceased WO2024142684A1 (ja) 2022-12-26 2023-11-22 創傷被覆材用粘着剤および創傷被覆材

Country Status (2)

Country Link
JP (1) JPWO2024142684A1 (https=)
WO (1) WO2024142684A1 (https=)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS544491A (en) * 1977-06-08 1979-01-13 Squibb & Sons Inc Medical adhesive
JP2006111847A (ja) * 2004-03-25 2006-04-27 Nippon Shokubai Co Ltd アクリル系ブロックポリマーとその用途
JP2011045494A (ja) * 2009-08-26 2011-03-10 Nichiban Co Ltd ハイドロコロイド型粘着剤組成物及びこれを基材に塗布した創傷材
JP2011182847A (ja) * 2010-03-05 2011-09-22 Three M Innovative Properties Co 医療用粘着剤組成物
WO2015178438A1 (ja) * 2014-05-20 2015-11-26 アルケア株式会社 皮膚用粘着剤組成物及び皮膚用貼付材
US20220111111A1 (en) * 2019-01-17 2022-04-14 Scapa Tapes Na Composition for use in wound dressings
JP2022161841A (ja) * 2021-04-08 2022-10-21 株式会社Moresco 粘着シートおよびその製造方法、ならびに創傷被覆材

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS544491A (en) * 1977-06-08 1979-01-13 Squibb & Sons Inc Medical adhesive
JP2006111847A (ja) * 2004-03-25 2006-04-27 Nippon Shokubai Co Ltd アクリル系ブロックポリマーとその用途
JP2011045494A (ja) * 2009-08-26 2011-03-10 Nichiban Co Ltd ハイドロコロイド型粘着剤組成物及びこれを基材に塗布した創傷材
JP2011182847A (ja) * 2010-03-05 2011-09-22 Three M Innovative Properties Co 医療用粘着剤組成物
WO2015178438A1 (ja) * 2014-05-20 2015-11-26 アルケア株式会社 皮膚用粘着剤組成物及び皮膚用貼付材
US20220111111A1 (en) * 2019-01-17 2022-04-14 Scapa Tapes Na Composition for use in wound dressings
JP2022161841A (ja) * 2021-04-08 2022-10-21 株式会社Moresco 粘着シートおよびその製造方法、ならびに創傷被覆材

Also Published As

Publication number Publication date
JPWO2024142684A1 (https=) 2024-07-04

Similar Documents

Publication Publication Date Title
JP4955146B2 (ja) 熱可塑性成分および超吸収性ポリマーを含む組成物
CN1329445C (zh) 超吸收性热塑性组合物和包括它的制品
US8110623B2 (en) Hot melt pressure sensitive adhesive composition that includes vegetable wax and articles including the same
US20040243042A1 (en) Facial masks for managing skin wounds
JP5850682B2 (ja) ホットメルト接着剤
EP3147331B1 (en) Water-absorbing resin particles, absorber comprising same, and absorbent article
CN109790437B (zh) 热熔粘合剂
WO2004103415A2 (en) Multi-dressing system for managing skin wounds
TW201504382A (zh) 熱熔黏著劑
CZ91099A3 (cs) Hydrofilní adhezivní hmota a její použití
CN106714744A (zh) 用于皮肤粘附医疗产品的缓冲粘合剂组合物
US20040241246A1 (en) Fluid absorbing adhesive paste
WO2020085299A1 (ja) ホットメルト接着剤
JP2004538257A (ja) ヒドロコロイド組成物
JP6891288B2 (ja) 粘着剤組成物
JP2000282006A (ja) ホットメルト接着剤組成物
CA2444732A1 (en) Mouldable hydrocolloid adhesive compositions
WO2006104660A1 (en) Occlusive wound dressing useful in tattoo removal
WO2024142684A1 (ja) 創傷被覆材用粘着剤および創傷被覆材
CZ20013230A3 (cs) Hydrokoloidní adhezivum s odolností proti zhorąení absorpční kapacity po provedení radiační sterilizace a jeho pouľití
JP3361547B2 (ja) ホットメルト接着剤
WO2024142685A1 (ja) 粘接着剤
WO2019004376A1 (ja) ホットメルト接着剤
JP6352360B2 (ja) ホットメルト接着剤
JP6055001B2 (ja) ホットメルト接着剤

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 23911466

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2024567297

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 23911466

Country of ref document: EP

Kind code of ref document: A1