WO2024106639A1 - Formulation complexe de prévention de perte de cheveux ayant une structure cœur-écorce, et aliment fonctionnel de santé - Google Patents
Formulation complexe de prévention de perte de cheveux ayant une structure cœur-écorce, et aliment fonctionnel de santé Download PDFInfo
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- WO2024106639A1 WO2024106639A1 PCT/KR2023/005270 KR2023005270W WO2024106639A1 WO 2024106639 A1 WO2024106639 A1 WO 2024106639A1 KR 2023005270 W KR2023005270 W KR 2023005270W WO 2024106639 A1 WO2024106639 A1 WO 2024106639A1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/14—Yeasts or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
Definitions
- the present invention relates to a complex preparation for preventing hair loss and a health functional food with a core-shell structure.
- hair loss In general, the causes of hair loss in humans include genetic factors, aging, taking medications, radiation treatment, and stress after a serious illness. From a biochemical and physiological perspective, hair loss is known to be caused by three main causes: hyperactivity, problems with scalp blood circulation, and deficiency of nutrients essential for hair metabolism.
- Minoxidil a representative hair loss treatment on the market, was originally a treatment for high blood pressure developed to lower blood pressure, but as a side effect of its use was hair growth, it has become more famous as a hair growth agent.
- minoxidil preparations can cause side effects such as scalp itching, erythema, contact dermatitis such as dead skin cells, and hirsutism (J Korean Med Assoc 2013 January; 56(1): 45-54).
- Propesia another representative hair loss treatment drug, inhibits the conversion of testosterone into dihydrotestosterone (DHT) by blocking the 5-alpha-reductase type 2 enzyme, which plays an important role in the development of male pattern baldness. It is known to inhibit progression. Propecia is known to have excellent hair loss prevention effects, but the reagents used to manufacture it are expensive and toxic, and since it works by artificially blocking the production of steroid hormones, various side effects can occur. There is a risk. Accordingly, there is still a need for the development of a safe treatment that has excellent hair loss prevention and hair growth promotion effects and has no side effects.
- DHT dihydrotestosterone
- brewer's yeast and biotin which are used as nutrients rather than as treatments, are recently widely used as emerging nutrients to prevent hair loss.
- L-cystine contained in brewer's yeast and biotin can provide a hair loss prevention agent rich in vitamin B, but if taken in excessive amounts or for a long period of time, side effects such as gout, which is a problem with brewer's yeast itself, occur.
- One object of the present invention is a composite preparation for preventing hair loss comprising a core-forming composition and a shell-forming composition as active ingredients, wherein the complex preparation includes: red herb extract; and a core layer comprising the core forming composition comprising celery extract; and a shell layer formed on the entire surface of the core layer, wherein the shell layer includes biotin extract; and the shell-forming composition comprising effective dry yeast, wherein the effective dry yeast includes dry brewer's yeast and dry yeast chromium, and the dry yeast chromium is present in an amount of 0.1 part by weight or more and 5 weight parts based on 100 parts by weight of the dry brewer's yeast.
- the object is to provide a composite preparation for preventing hair loss, which includes less than 100 parts, and satisfies the ratio of the outer diameter of the composite preparation to the outer diameter of the core from 1:0.3 to 1:0.65.
- Another object of the present invention is to provide a health functional food for preventing or treating hair loss containing the above complex preparation.
- a complex preparation for preventing hair loss comprising a core-forming composition and a shell-forming composition as active ingredients, wherein the complex preparation includes: red herb extract; and a core layer comprising the core forming composition comprising celery extract; and a shell layer formed on the entire surface of the core layer, wherein the shell layer includes biotin extract; and the shell-forming composition comprising effective dry yeast, wherein the effective dry yeast includes dry brewer's yeast and dry yeast chromium, and the dry yeast chromium is present in an amount of 0.1 part by weight or more and 5 weight parts based on 100 parts by weight of the dry brewer's yeast. It provides a composite formulation for preventing hair loss, wherein the ratio of the outer diameter of the composite formulation: the outer diameter of the core satisfies 1:0.3 to 1:0.65.
- the present invention is intended to provide a complex preparation for preventing hair loss in which the chromium content in the dried yeast chromium is 1 wt% or less.
- the composite preparation is prepared according to the dissolution test method 2 (paddle method) of the Korean Pharmacopoeia at 37°C, pH 4.0, and the shell-forming composition contained in the water eluate is 70 to 70% of the total weight of the active ingredient after 1 hour.
- the object is to provide a composite formulation for preventing hair loss that satisfies a dissolution profile of 85%, in which the core-forming composition is dissolved in the range of 5 to 10% of the total weight of the active ingredient after 1 hour.
- the composite preparation is prepared according to the dissolution test method 2 (paddle method) of the Korean Pharmacopoeia, at 37°C, pH 4.0, and in a water eluate, the shell-forming composition contained within 5 to 5% of the total weight of the active ingredient after 4 hours.
- the object is to provide a composite formulation for preventing hair loss that satisfies a dissolution profile in which 10% of the core-forming composition is dissolved in the range of 80 to 90% of the total weight of the active ingredient after 4 hours.
- the shell-forming composition includes selenium, cellulose, magnesium stearate, catechin, cathinone, tryptamine, P-octopamine, and P-Tyramine. ), Synephrine, and ephedrine.
- the complex preparation for preventing hair loss provided by the present invention has excellent efficacy in preventing and treating problems such as hair loss and brittle nails.
- the complex preparation for preventing hair loss according to the present application is characterized by containing a substance effective against hair loss as a shell-forming composition, and at the same time containing a core-forming composition with an antioxidant effective against gout to solve problems such as gout, which is a side effect thereof.
- the present invention has a composite preparation containing the above-mentioned active ingredients, wherein the composite preparation consists of a structure of a core and a shell, and the ratio of the outer diameter of the composite preparation to the outer diameter of the core satisfies 1:0.3 to 1:0.65. It is characterized by:
- the ratio of the outer diameter of the core satisfies a certain range (i.e., by adjusting the ratio of the core and shell), so that it has the characteristic of effectively controlling the amount of active ingredient dissolved within a certain time. do.
- the core-forming composition and shell-forming composition included as active ingredients are not eluted at once, but are prepared in the form of a composite preparation to satisfy the specific structure of the core-shell, so that the required composition is eluted in high content within a certain period of time and then administered in two doses. It is characterized by continuous elution of various substances.
- the hair loss prevention effect can be maintained continuously, and at the same time, the core-forming composition begins to be secreted from about 4 hours after administration of the complex preparation (i.e., the time it passes through the stomach and stays in the intestines).
- the core-forming composition is a natural substance containing antioxidants that are good for gout, but if such substances are secreted from the stomach after administration, side effects such as heartburn may occur due to their acidity.
- the main feature of the composite preparation according to the present application is that in order to solve this problem, it is simply formed into a core-shell structure, and the core-forming composition is adjusted to be secreted after a certain period of time after administration.
- the composite preparation according to the present invention is characterized by including a core-forming composition that can continuously have the existing hair loss prevention effect and at the same time solve problems such as gout, which are side effects, and each of them It is characterized by exhibiting superior effects by controlling the administration rate of the composition.
- Figure 1 is a diagram schematically showing a combination preparation according to an exemplary embodiment of the present invention.
- extract refers to an extract obtained by extraction treatment, a diluted or concentrated liquid of the extract, a dried product obtained by drying the extract, a crude product or purified product of the extract, or a mixture thereof. etc., includes the extract itself and all formulations of the extract that can be formed using the extract.
- extract of this specification follows the dictionary definition and is obtained by concentrating a specific component in the extract.
- the specific active ingredient is separated with an appropriate solvent, the solvent is completely or mostly evaporated, and the remaining lump or powder is adjusted according to the standard.
- extract can be used to include all three types: semifluid or syrup, pill dealer or solid, dried powder, etc. there is.
- the extract in this specification follows the dictionary definition and may mean a liquid substance extracted from a specific substance or condition.
- a complex preparation for preventing hair loss comprising a core-forming composition and a shell-forming composition as active ingredients, wherein the complex preparation includes: red herb extract; and a core layer comprising the core forming composition comprising celery extract; and a shell layer formed on the entire surface of the core layer, wherein the shell layer includes biotin extract; and the shell-forming composition comprising effective dry yeast, wherein the effective dry yeast includes dry brewer's yeast and dry yeast chromium, and the dry yeast chromium is present in an amount of 0.1 part by weight or more and 5 weight parts based on 100 parts by weight of the dry brewer's yeast. It provides a composite formulation for preventing hair loss, wherein the ratio of the outer diameter of the composite formulation: the outer diameter of the core satisfies 1:0.3 to 1:0.65.
- the composite preparation according to the present invention is characterized in that it contains a core-forming composition that can continue to have the existing hair loss prevention effect and at the same time solve problems such as gout, which is a side effect thereof.
- each composition It is characterized by better effectiveness by controlling the administration rate.
- drying of the extract can be done by a known method as long as useful components from the collected natural material are not destroyed, for example, by natural drying in the shade.
- crushing or pulverization can be performed to a degree that the useful components of the plant can be sufficiently extracted during the subsequent extraction process.
- the drying and crushing or pulverizing processes can be performed in reverse order or repeatedly as needed.
- the extraction method is not particularly limited, and extraction may be performed according to a method commonly used in the technical field.
- Non-limiting examples of the extraction method include hot water extraction, ultrasonic extraction, filtration, and reflux extraction, which may be performed alone or by combining two or more methods.
- the type of extraction solvent used to extract natural substances in the present invention is not particularly limited, and any solvent known in the art can be used.
- biotin is a vitamin containing sulfur and is involved in fat and carbohydrate metabolism.
- Biotin acts as an essential cofactor for four decarboxylase enzymes, three of which are involved in calorie and amino acid metabolism and one that acts to produce fatty acids.
- Biotin is referred to as ‘vitamin H’ because it has a positive effect on the skin and hair.
- biotin is involved in the production of blood cells and secretion of male hormones, and along with other B vitamins, it facilitates the functioning of the nervous system and bone marrow.
- pomegranate, Schisandra chinensis, bokbunja, red ginseng, grape, mulberry, and white lotus root used in the production of the red herb extract.
- Preparation of the Hongweed extract is as follows.
- Red herb extract is known to have excellent antioxidant properties.
- the celery extract refers to an extract of commercially available celery that is finely chopped and dried in powder form, and is known to have excellent anti-oxidant performance, similar to the Hongweed extract.
- a complex preparation for preventing hair loss comprising a core-forming composition and a shell-forming composition as active ingredients
- the complex preparation includes: red herb extract; and a core layer comprising the core forming composition comprising celery extract; and a shell layer formed on the entire surface of the core layer.
- the composite preparation according to the present application simply forms a physical core-shell structure, and does not control the secretion of ingredients according to the pH of the substance such as medical double-layer tablets or triple-layer tablets, but rather adjusts the outer diameter ratio of the core and shell layers. It is characterized by simply controlling the amount of ejection.
- Each core layer and shell layer will be described below.
- the shell layer includes biotin extract; and the shell-forming composition containing effective dry yeast.
- the shell layer may contain active ingredients that have effects such as preventing hair loss and nail breakage.
- the biotin extract is 0.01 part by weight or more and 0.1 part by weight or less based on 100 parts by weight of the shell-forming composition; Preferably, it may be 0.01 part by weight or more and 0.05 part by weight or less, and more specifically, it may include 0.02 part by weight.
- the effective dry yeast may be 80 parts by weight or more and 97 parts by weight or less, preferably 85 parts by weight or more and 96 parts by weight or less, more preferably 90 parts by weight or more and 95 parts by weight or less. Specifically, it may include 94 parts by weight.
- the effective dry yeast includes dry beer yeast and dry yeast chromium, and the dry yeast chromium may be included in an amount of 0.1 parts by weight or more and 5 parts by weight or less based on 100 parts by weight of the dry beer yeast. .
- the effective dry yeast includes dry beer yeast and dry yeast chromium, and based on 100 parts by weight of the dry beer yeast, the dry yeast chromium is 0.1 part by weight or more and 5 parts by weight or less, preferably 0.2 parts by weight. It may be more than 3 parts by weight and less than 3 parts by weight, more preferably 0.3 parts by weight or more and 1 part by weight or less, and specifically, it may be 0.48 parts by weight.
- the shell-forming composition as described above may include biotin extract and effective dry yeast, and may specifically include parts by weight as described above. If it contains the above parts by weight, it can show a special effect in preventing and preventing hair loss at the same time as supplying vitamin B. Additionally, by including the above parts by weight of dried yeast chromium, nutrients and vitamins are added compared to when only the existing dry brewer's yeast is included. It has features that can be supplied.
- a complex preparation for preventing hair loss wherein the chromium content in the dried yeast chromium is 1 wt% or less.
- the chromium content may refer to the atomic content included, and the chromium content may be 1 wt% or less, specifically 0.5 wt% or less, 0.1 wt% or more, and specifically 0.3 wt%.
- the shell-forming composition includes selenium, cellulose, magnesium stearate, catechin, cathinone, tryptamine, P-Octopamine, and P-tyramine (P- Provides a complex preparation for preventing hair loss further comprising at least one selected from the group consisting of Tyramine, Synephrine, and Ephedrine.
- compositions generally correspond to substances that can be included in complex preparations, such as minerals and solvents.
- the shell layer may be formed on the entire surface of the core layer.
- the combined preparation can be confirmed in detail in Figure 1.
- Figure 1 is a diagram schematically showing a composite preparation according to an embodiment of the present invention. It can be seen that a shell layer is formed on the front part of the core layer of the composite preparation. As described above, a shell layer must be formed on the front surface to ensure that the core-forming composition is not extracted in high amounts at the beginning of administration, thereby solving gastrointestinal problems such as heartburn.
- the core layer is a red herb extract; and the core-forming composition containing celery extract.
- the core layer corresponds to a composition for solving problems such as ventilation, which is a problem during long-term administration of the shell-forming composition included in the above-mentioned shell layer.
- the core layer corresponds to a layer used to alleviate the side effects of a complex preparation for preventing hair loss rather than the effect of preventing hair loss.
- 70 parts by weight or more and 90 parts by weight or less of the Hongweed extract based on 100 parts by weight of the core forming composition Preferably, it may be 75 parts by weight or more and 85 parts by weight or less, and may specifically include 80 parts by weight.
- the celery extract may be 10 parts by weight or more and 30 parts by weight or less, preferably 15 parts by weight or more and 25 parts by weight or less, and may specifically include 20 parts by weight. there is.
- the core-forming composition includes a solvent that dissolves the Hongweed extract and the celery extract, and the solvent may include water.
- the solid content of the core forming composition may be 80 wt%.
- the core forming composition may satisfy the above composition and content.
- the antioxidant effect can be maximized by satisfying the above composition and content, and it also has excellent sensory characteristics by including the above content of celery extract, which has an antioxidant effect.
- the antioxidant effect may be the best, but the complex preparation itself may contain an excessive amount of sour scent, which may cause problems with ingestion.
- a composite formulation for preventing hair loss wherein the ratio of the outer diameter of the composite formulation to the outer diameter of the core satisfies 1:0.3 to 1:0.65.
- the ratio of the outer diameter of the composite preparation to the outer diameter of the core is 1:0.3 to 1:0.65, preferably 1:0.35 to 1:0.6, more preferably 1:0.4 to 1:0.5. ratio can be satisfied.
- the outer diameter of the composite preparation may be 5 mm or more and 40 mm or less.
- the outer diameter of the composite preparation may be 5 mm or more and 40 mm or less, preferably 7 mm or more and 30 mm or less, and more preferably 10 mm or more and 20 mm or less.
- the effective substance according to the present application be included in the desired amount and also be formed into a size suitable for swallowing.
- complex preparations for preventing hair loss contain only biotin and yeast.
- side effects such as gout may occur, and the present application is characterized by including a core-forming composition for antioxidant effect.
- the present application can continuously have a hair loss prevention effect, and at the same time, the core-forming composition begins to be secreted from about 4 hours after administration of the complex preparation (i.e., the time it passes through the stomach and stays in the intestines).
- the core-forming composition is a natural substance containing antioxidants that are good for gout, but if such substances are secreted from the stomach after administration, side effects such as heartburn may occur due to their acidity.
- the composite preparation according to the present application was simply formed into a core-shell structure and the outer diameter ratio was adjusted as described above.
- Figure 1 is a diagram schematically showing a composite preparation according to an embodiment of the present invention.
- the outer diameter of the composite preparation may be indicated by B, and in this case, the outer diameter of the core may be indicated by A. That is, the outer diameter can be expressed as the radius of a sphere or circle.
- the composite preparation contains 70% of the total weight of the active ingredient after 1 hour in a water eluate at 37°C, pH 4.0, and water according to the Korean Pharmacopoeia Dissolution Test Method 2 (Paddle Method).
- the composite preparation contains 5% of the total weight of the active ingredient after 4 hours in a water eluate at 37°C, pH 4.0, and water according to the Korean Pharmacopoeia Dissolution Test Method 2 (Paddle Method).
- a composite formulation for preventing hair loss that satisfies a dissolution profile in which the core-forming composition is dissolved in the range of ⁇ 10% and 80-90% of the total weight of the active ingredient after 4 hours.
- the preferred dosage of the combination preparation varies depending on the patient's condition and weight, degree of disease, drug type, administration route and period, but can be appropriately selected by a person skilled in the art.
- the content of the active ingredient in the combination preparation of the present invention may vary depending on the degree of the disease.
- a preferred total dosage of the composition of the present invention may be about 0.01 ⁇ g to 1,000 mg per kg of patient body weight per day, most preferably 0.1 ⁇ g to 100 mg per kg of patient body weight per day.
- the effective dose for the patient is determined by considering various factors such as the route of administration and number of treatments of the pharmaceutical composition, as well as the patient's age, weight, health status, gender, severity of the disease, diet, and excretion rate. Since it is determined, taking these points into consideration, anyone with ordinary knowledge in the art will be able to determine an appropriate effective dosage according to the specific use of the combination preparation as a hair loss prevention or treatment agent.
- the combination preparation according to the present invention is not particularly limited in its formulation, administration route, and administration method as long as it exhibits the effects of the present invention.
- it is prepared using diluents or excipients such as commonly used fillers, extenders, binders, wetting agents, disintegrants, and surfactants.
- a health functional food containing the complex preparation for preventing hair loss according to the present application is provided.
- the health functional food may be formulated with one selected from the group consisting of tablets, pills, powders, granules, powders, capsules, and liquid formulations, further including one or more of carriers, diluents, excipients, and additives.
- Foods to which the above acteoside or its foodologically acceptable salt can be added include various foods, powders, granules, tablets, capsules, syrups, beverages, gum, tea, vitamin complexes, nutritional supplements, health functional foods, and Food additives, etc.
- Additives that may be further included in the health functional food include natural carbohydrates, flavors, nutrients, vitamins, minerals (electrolytes), flavors (synthetic flavors, natural flavors, etc.), colorants, fillers (cheese, chocolate, etc.) , pactic acid and its salts, alginic acid and its salts, organic acids, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, antioxidants, glycerin, alcohol, carbonating agents and pulp. there is.
- natural carbohydrates examples include monosaccharides such as glucose, fructose, etc.; Disaccharides such as maltose, sucrose, etc.; and polysaccharides, such as common sugars such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol, and erythritol.
- natural flavoring agents thaumatin, stevia extract (e.g., rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can be advantageously used.
- the health functional food may contain pH adjusters, stabilizers, preservatives, glycerin, alcohol, carbonating agents used in carbonated drinks, etc., and may contain pulp for the production of natural fruit juice and vegetable drinks. These ingredients can be used independently or in combination.
- the carriers, excipients, diluents and additives include, but are not limited to, lactose, dextrose, sucrose, sorbitol, mannitol, erythritol, starch, gum acacia, calcium phosphate, alginate, gelatin, calcium phosphate, calcium.
- the health functional food When formulating the health functional food, it is prepared using diluents or excipients such as commonly used fillers, extenders, binders, wetting agents, disintegrants, and surfactants.
- diluents or excipients such as commonly used fillers, extenders, binders, wetting agents, disintegrants, and surfactants.
- Celery extract was used by finely chopping commercially available celery and drying it in powder form.
- the celery extract and the red herb extract were added to 100 ml of water at a weight ratio of 20:80, and the solid content was 85 wt%.
- a shell-forming composition was formed so that the composition of biotin (mir int) extract: dried brewer's yeast: dried yeast chromium: and other compositions satisfied the ratio of 0.02:93.6:0.48:5.9. At this time, other compositions included selenium mixed preparation, crystalline cellulose, silicon dioxide, and magnesium stearate.
- a core-shell structure was formed using a composite formulation that satisfies the outer diameters shown in Table 1 below.
- Example 1 a composite formulation was formed by forming only the shell-forming composition into a circle with a size of 20 mm, without including the core-forming composition.
- Example 1 a composite formulation was formed by forming only the core-forming composition into a circle with a size of 20 mm, without including the shell-forming composition.
- Example 1 1 hour later 4 hours later Core forming composition (%) Shell-forming composition (%) Core forming composition (%) Shell-forming composition (%) Shell-forming composition (%) Example 1 5 75 85 7 Example 2 7 76 83 5 Example 3 8 85 90 8 Example 4 8 85 90 8 Comparative Example 1 25 70 70 15 Comparative Example 2 7 76 40 10 Comparative Example 3 5 75 85 7 Comparative Example 4 - 100 - 100 Comparative Example 5 100 - 100 -
- the composite preparation for preventing hair loss of Examples 1 to 4 according to the present application includes a substance effective against hair loss as a shell-forming composition, and at the same time, in order to solve problems such as gout, which is a side effect thereof, a core-forming composition is added as an antioxidant effective against gout. It can be seen that it is characterized by including.
- the present invention has a composite preparation containing the above-mentioned active ingredients, wherein the composite preparation consists of a structure of a core and a shell, and the ratio of the outer diameter of the composite preparation to the outer diameter of the core satisfies 1:0.3 to 1:0.65.
- Example 1 to 4 about 70 to 85% of the shell-forming composition was released based on the total weight of the resting ingredients about 1 hour after administration, and at this time, 5 to 10% of the core-forming composition was released. Only was released. In other words, the state after 1 hour corresponds to the time and conditions when the complex preparation stays in the stomach in the body. In other words, when it stays in the stomach, a lot of the water-soluble shell-forming composition is released, which can have a hair loss prevention effect.
- the core-forming composition contains antioxidants with strong acidity, and its release is minimal, so it has the characteristic of preventing gastrointestinal disorders such as heartburn. was able to confirm.
- the ratio of the outer diameter of the core satisfies a certain range (i.e., by adjusting the ratio of the core and shell), so that it has the characteristic of effectively controlling the amount of active ingredient dissolved within a certain time. It was found that it was possible.
- the core-forming composition and shell-forming composition included as active ingredients are not eluted at once, but are prepared in the form of a composite preparation to satisfy the specific structure of the core-shell, so that the required composition is eluted in high content within a certain period of time and then administered in two doses. It was found that it was characterized by continuous elution of various substances.
- Comparative Examples 1 to 3 have a core-shell structure, but correspond to cases where the ratio of the outer diameter of the composite preparation and the outer diameter of the core is not satisfied. Specifically, in Comparative Example 1, it was confirmed that a large amount of the core-forming composition was released after 1 hour, leading to gastrointestinal disorders such as heartburn. In Comparative Example 2, it was found that the core-forming composition was not released in a small amount even after 1 hour and 4 hours, so it could not prevent gout, which is an existing side effect. In the case of Comparative Example 3, the ratio according to the present application was satisfactory, but the outer diameter was large, making administration of the drug difficult. Comparative Examples 4 and 5 have only one composition rather than a core-shell structure. Comparative Example 4 can show a hair loss prevention effect but cannot solve side effects such as gout, and Comparative Example 5 has a hair loss prevention effect. It could not be used as a combination preparation because it could not express itself.
- the main feature of the present application is that it can continuously have a hair loss prevention effect and at the same time, the core forming composition begins to be secreted at the desired content from about 4 hours after administration of the complex preparation (i.e., the time it passes through the stomach and stays in the intestines).
- the core-forming composition is a natural substance containing antioxidants that are good for gout, but if such substances are secreted from the stomach after administration, side effects such as heartburn may occur due to their acidity.
- the composite preparation according to the present application was simply formed into a core-shell structure, and it was confirmed that the main feature of the core-forming composition was that it was adjusted to be secreted after a certain period of time after administration.
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Abstract
La présente invention concerne une formulation complexe de prévention de perte de cheveux ayant une structure cœur-écorce, et un aliment fonctionnel de santé. Plus particulièrement, la formulation complexe de prévention de perte de cheveux selon la présente invention est fournie sous la forme d'une formulation complexe pour satisfaire une structure cœur-écorce spécifique, et est ainsi caractérisée par l'élution d'une teneur élevée d'une composition requise dans une certaine période de temps et puis par l'élution en continu de deux types de substances. Par conséquent, un effet supérieur est obtenu par ajustement du taux d'administration de chacun des composants.
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JP2014208714A (ja) * | 2014-08-13 | 2014-11-06 | 株式会社ツツミプランニング | 毛穴を閉塞する皮脂硬化物の溶解能を有する養毛剤 |
KR20140141274A (ko) * | 2013-05-31 | 2014-12-10 | 주식회사 씨엘디 테크놀러지 | 발모 촉진 또는 탈모 방지용 조성물 |
KR20200091611A (ko) * | 2019-01-23 | 2020-07-31 | 김성수 | 맥주효모 추출물을 함유한 탈모 방지용 기능성 삼푸 조성물 |
KR102216882B1 (ko) * | 2020-09-08 | 2021-02-19 | 한국콜마주식회사 | 코어-쉘 복합 분체 및 이를 포함하는 항염증용 또는 항산화용 조성물 |
KR102461437B1 (ko) * | 2022-05-02 | 2022-11-02 | 최진원 | 가르시니아 캄보지아 추출액을 포함하는 비만 예방 또는 약학적 조성물 및 건강기능성 식품 |
KR102508704B1 (ko) * | 2022-11-17 | 2023-03-09 | 최진원 | 코어쉘 구조의 탈모 방지용 복합 제제 및 건강기능성 식품 |
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KR20140141274A (ko) * | 2013-05-31 | 2014-12-10 | 주식회사 씨엘디 테크놀러지 | 발모 촉진 또는 탈모 방지용 조성물 |
JP2014208714A (ja) * | 2014-08-13 | 2014-11-06 | 株式会社ツツミプランニング | 毛穴を閉塞する皮脂硬化物の溶解能を有する養毛剤 |
KR20200091611A (ko) * | 2019-01-23 | 2020-07-31 | 김성수 | 맥주효모 추출물을 함유한 탈모 방지용 기능성 삼푸 조성물 |
KR102216882B1 (ko) * | 2020-09-08 | 2021-02-19 | 한국콜마주식회사 | 코어-쉘 복합 분체 및 이를 포함하는 항염증용 또는 항산화용 조성물 |
KR102461437B1 (ko) * | 2022-05-02 | 2022-11-02 | 최진원 | 가르시니아 캄보지아 추출액을 포함하는 비만 예방 또는 약학적 조성물 및 건강기능성 식품 |
KR102508704B1 (ko) * | 2022-11-17 | 2023-03-09 | 최진원 | 코어쉘 구조의 탈모 방지용 복합 제제 및 건강기능성 식품 |
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