WO2024062641A1 - Élément de couvercle de capteur d'image, système d'observation et procédé d'observation - Google Patents

Élément de couvercle de capteur d'image, système d'observation et procédé d'observation Download PDF

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Publication number
WO2024062641A1
WO2024062641A1 PCT/JP2023/003218 JP2023003218W WO2024062641A1 WO 2024062641 A1 WO2024062641 A1 WO 2024062641A1 JP 2023003218 W JP2023003218 W JP 2023003218W WO 2024062641 A1 WO2024062641 A1 WO 2024062641A1
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WO
WIPO (PCT)
Prior art keywords
sample
cover member
image sensor
imaging device
image
Prior art date
Application number
PCT/JP2023/003218
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English (en)
Japanese (ja)
Inventor
理映子 水内
敏弘 今田
勇太 橋本
武士 松代
由紀夫 平岡
Original Assignee
株式会社 東芝
東芝インフラシステムズ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 株式会社 東芝, 東芝インフラシステムズ株式会社 filed Critical 株式会社 東芝
Publication of WO2024062641A1 publication Critical patent/WO2024062641A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/34—Measuring or testing with condition measuring or sensing means, e.g. colony counters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B5/00—Optical elements other than lenses

Definitions

  • Embodiments of the present invention relate to a cover member for an image sensor, an observation system, and an observation method.
  • an imaging device called an on-chip image sensor (a device that can capture images by placing a sample directly on the sensor) has also been developed.
  • an on-chip image sensor With an on-chip image sensor, a clear image can be obtained at a certain distance (for example, several tens of micrometers) above the image sensor, so there is no need for focusing work.
  • a liquid sample is dropped onto the image sensor several times using a micropipette or similar device, the sample is photographed, and the object to be observed (such as a microorganism) contained within the sample is observed from the image obtained.
  • the object to be observed such as a microorganism
  • the cover member of the image sensor according to the embodiment has a presser part that presses the surface of the liquid sample placed in the sample placement space above the image sensor included in the imaging device so that the surface of the liquid sample becomes flat. .
  • FIG. 1 is a diagram illustrating an example of the configuration of an entire system including a cover member of an image sensor according to an embodiment.
  • FIG. 2 is a diagram showing an example of the structure of the cover member 4 shown in FIG. 1 when viewed from above with the cover member 4 attached to the imaging device 1.
  • FIG. 3 is a diagram showing an example of the state of the sample S before the cover member 4 is attached to the imaging device 1.
  • FIG. 4 is a diagram showing an example of the state of the sample S after the cover member 4 is attached to the imaging device 1.
  • FIG. 5 is a diagram showing an example (part 1) of the structure of the cover member 4.
  • FIG. 6 is a diagram showing an example (part 2) of the structure of the cover member 4.
  • FIG. 1 is a diagram illustrating an example of the configuration of an entire system including a cover member of an image sensor according to an embodiment.
  • FIG. 2 is a diagram showing an example of the structure of the cover member 4 shown in FIG. 1 when viewed from above with the cover member 4 attached to the imaging
  • FIG. 7 is a diagram showing an example (part 3) of the structure of the cover member 4.
  • FIG. 8 is a diagram showing a longitudinal cross-sectional shape of the cover member 4 shown in FIG. 7.
  • FIG. 9 is a diagram showing an example of an image obtained from the image sensor 11 when photographing is performed without the cover member 4 attached.
  • FIG. 10 is a diagram showing an example of an image obtained from the image sensor 11 when photographing is performed with the cover member 4 attached.
  • FIG. 11 is a diagram showing an example of the structure of the cover member 4 according to the first modification example when attached to the imaging device 1 as viewed from above.
  • FIG. 12 is a diagram showing an example of the state of the sample S when the cover member 4 according to Modification Example 1 is attached to the imaging device 1.
  • FIG. 13 is a diagram showing an example of the state of the sample S when the cover member 4 according to Modification Example 2 is attached to the imaging device 1.
  • FIG. 14 is a diagram showing an example of an image of the sample S before drying.
  • FIG. 15 is a diagram showing an example of an image after drying the sample S.
  • FIG. 16 is a flowchart showing an example (part 1) of the method for observing the sample S.
  • FIG. 17 is a flowchart showing an example (part 2) of the method for observing the sample S.
  • FIG. 1 shows an example of the configuration of the entire system including the cover member of the image sensor according to the embodiment. Further, FIG. 2 shows an example of the structure of the cover member 4 shown in FIG. 1 when viewed from above in a state where it is attached to the imaging device 1.
  • FIG. 1 shows an imaging device 1, an information processing device 2, a water treatment facility 3, a cover member 4, and a lighting 5. At least the imaging device 1 and the cover member 4 constitute an observation system.
  • the imaging device 1 corresponds to an on-chip image sensor, and includes an image sensor 11 inside, a frame 1B arranged around the image sensor 11, and a liquid film on the image sensor 11 and the frame 1B.
  • a sample placement space 1A is provided so that the sample S can be placed therein.
  • the sample placement space 1A corresponds to a concave depression formed in a part of the upper part of the main body of the imaging device 1, and accommodates the liquid sample S.
  • the sample S is, for example, activated sludge water (sludge water) containing microorganisms, or treated water containing flocs.
  • the cover member 4 has a presser portion 4A that presses the surface of the liquid sample S placed in the sample placement space 1A so that the surface of the liquid sample S becomes flat.
  • the holding part 4A has a flat surface that comes into contact with the sample S.
  • At least the pressing portion 4A and the portion vertical to it of the cover member 4 are made of a material that transmits light.
  • a material that transmits light is made of a material that transmits light.
  • the cover member 4 is made of quartz glass or a resin such as COP (Cyclo-Olefin Polymer).
  • the shape of the cover member 4 is circular, but the shape of the cover member 4 is not limited to this example, and may be square, for example, as described later, or may have other shapes. It may be.
  • the illumination 5 emits light toward the cover member 4 from above the cover member 4 attached to the imaging device 1 .
  • the light from the illumination 5 passes through the cover member 4 and illuminates the sample S.
  • the lighting 5 is, for example, a white LED (Light Emitting Diode).
  • the present invention is not limited to this example, and any type of illumination may be used as long as it emits light that passes through the cover member 4.
  • the image sensor 11 photographs the sample S as a subject and outputs the photographed result as a two-dimensional image.
  • the imaging device 1 transmits image information obtained from the image sensor 11 to the information processing device 2 .
  • the information processing device 2 corresponds to a computer, and displays the information of the image transmitted from the imaging device 1 on a display device, and displays various observation objects included in the sample S shown in the image, for example. It analyzes microorganisms, flocs, etc. (hereinafter referred to as "microorganisms, etc.”), and transmits the analysis results to the water treatment facility 3.
  • the information processing device 2 determines the types of microorganisms contained in the sludge water and the amount per unit volume from the image, and transmits information indicating the determined types of microorganisms and the amount per unit volume to the water treatment facility 3 (for example, a sewage treatment plant). Also, for example, if the sample S is water to be treated that contains flocs, the information processing device 2 determines the size of the flocs contained in the water to be treated and the amount per unit volume, and transmits information indicating the determined size of the flocs and the amount per unit volume to the water treatment facility 3 (for example, a water purification plant).
  • the water treatment facility 3 controls a predetermined control target based on the information transmitted from the information processing device 2. For example, if the water treatment facility 3 is a sewage treatment plant, the amount of deaeration in a predetermined tank may be controlled depending on the type of microorganisms contained in the sludge water and the amount per unit volume. For example, if the water treatment facility 3 is a water treatment plant, the water is injected into a predetermined water treatment pond (for example, a mixing pond) depending on the size of flocs contained in the water to be treated and the amount per unit volume. control of drugs (e.g. flocculants);
  • drugs e.g. flocculants
  • FIG. 3 shows an example of the state of the sample S before the cover member 4 is attached to the imaging device 1.
  • FIG. 4 shows an example of the state of the sample S after the cover member 4 is attached to the imaging device 1.
  • the vertical length of the sample mounting space 1A shown in FIG. 3 (the depth from the upper surface of the imaging device 1 to the surface of the image sensor 11) is a, and the depth of field of the image sensor 11 is x.
  • a is, for example, 4 to 5 mm
  • x is, for example, several tens of ⁇ m.
  • a predetermined amount of the liquid sample S containing the observation target T is dropped into the sample mounting space 1A above the image sensor 11 using a micropipette or the like.
  • a part of the sample S may not fall within the depth of field x of the image sensor 11.
  • a clear image cannot be obtained from the image sensor 11.
  • the observation target T is a light microorganism or a microorganism that does not sink easily
  • the microorganism does not fall within the depth of field x of the image sensor 11 and appears blurred in the two-dimensional image of the image sensor 11. This makes it impossible to properly observe light microorganisms, etc.
  • the sample S may not be sufficiently spread over the entire surface of the image sensor. Moreover, the sample S with a rounded surface is likely to fluctuate. In such a state, a clear image cannot be obtained from the image sensor 11. For example, the peripheral image portion of the two-dimensional image of the image sensor 11 becomes unclear, making it impossible to properly observe the observation target T that should be reflected there.
  • the cover member 4 is attached to the imaging device 1. Specifically, the convex portion of the cover member 4 (that is, the holding portion 4A) enters the concave portion of the imaging device 1 (that is, the portion excluding the sample S in the sample mounting space 1A). At this time, a portion around the holding portion 4A (a portion of the surface of the cover member 4) rests on the hook portion 1C of the imaging device 1 (a portion of the upper surface of the imaging device 1).
  • the holding part 4A of the holding part 4A has a flat surface at the part that contacts the sample S, and presses the surface of the sample S so that the surface of the sample S becomes flat. At this time, the surface of the holding portion 4A in contact with the sample S is parallel to the surface of the image sensor 11.
  • the holding part 4A presses the surface of the sample S so that the sample S falls within the depth of field x of the image sensor 11.
  • the holding portion 4A has a vertical length ax that allows the sample S to fall within the depth of field x of the image sensor 11.
  • This "vertical length a-x of the holding part 4A" is the length obtained by subtracting the "depth of field x of the image sensor 11" from the aforementioned "vertical length a of the sample mounting space 1A". It is.
  • the cover member 4 pushes the surface of the sample S so that the surface of the sample S becomes flat.
  • the holding portion 4A has a cross-sectional shape and dimensions that match the horizontal cross-sectional shape and dimensions of the sample mounting space 1A.
  • the horizontal cross-sectional shape of the holding portion 4A is square and has approximately the same dimensions as the dimensions of m ⁇ m.
  • it is desirable that the shapes and dimensions of both are adjusted so that the holding portion 4A can fit comfortably into the sample placement space 1A without creating a gap.
  • cover member 4 (Various shapes of cover member 4)
  • the shape of the cover member 4 may be changed as appropriate depending on the structure of the imaging device 1 to which the cover member 4 is attached, and the environment and application in which the cover member 4 is used.
  • FIG. 8 shows a longitudinal cross-sectional shape of the cover member 4 shown in FIG. 7. As shown in FIG.
  • FIG. 5 shows a cover member 4 having a structure similar to that described in FIGS. 1 and 2. That is, the cover member 4 shown in FIG. 5 includes a rectangular prism-shaped structure 41 forming the holding part 4A, and a flat plate-shaped structure 42 having a surface that comes into contact with the hook part 1C of the imaging device 1 described above. including.
  • the flat structure 42 has a circular shape when viewed from above.
  • Such a circular structure 42 has no sharp corners, and can prevent hands from getting hurt when handling the cover member 4.
  • the cover member 4 shown in FIG. 6 has a different surface shape from the above-described imaging device 1. That is, the cover member 4 shown in FIG. 6 includes a rectangular prism-shaped structure 41 forming the holding part 4A, and a flat plate-shaped structure 43 having a surface that comes into contact with the hook part 1C of the imaging device 1 described above. including.
  • the flat structure 43 has a square shape when viewed from above.
  • Such a square structure 42 is relatively easy to manufacture and easy to handle during manufacture.
  • the cover member 4 shown in FIGS. 7 and 8 has a surface shape different from that of the imaging device 1 described above, for example, an imaging device in which the hook portion 1C is stepped in two steps (for example, the first hook portion 1C This is applied to an imaging device (imaging device) which has a second-stage hook portion 1D in addition to the hook portion 1D above the hook portion 1D. Note that an imaging device having this type of structure will be described later.
  • the cover member 4 shown in FIGS. 7 and 8 includes a rectangular prism-shaped structure 41 forming a holding part 4A, a cylindrical structure 44 having a surface that comes into contact with the first hook part 1C, and two parts. It includes a flat structure 45 having a surface that comes into contact with the hook portion 1D of the step.
  • the inside of the cylindrical structure 44 is hollow, and an empty space 46 is formed above the structure 41.
  • the flat structure 45 is viewed from above, there is a space 46 in the center surrounded by the cylindrical structure 44, and the structure 41 is located at the back of the space 46.
  • the structures 44 and 45 may be made of a material that does not transmit light.
  • the cover member 4 having such a structure can be used even when the image sensor 11 and the sample placement space 1A are provided deep from the upper surface of the imaging device. Further, since there is no need to increase the vertical thickness of the square columnar structure 41 forming the holding portion 4A, the clarity of the image is not reduced, and it is light and easy to carry.
  • the entire sample S is placed within the depth of field x of the image sensor 11.
  • the observation target T is light microorganisms or microorganisms that are difficult to sink, they fall within the depth of field x of the image sensor 11 and are clearly reflected in the two-dimensional image of the image sensor 11, so light microorganisms, etc. can be observed.
  • the sample S sufficiently spreads over the entire surface of the image sensor without being affected by surface tension, the image area at the periphery of the two-dimensional image of the image sensor 11 also becomes clear, and the observation target T reflected there also becomes clear. Can be observed appropriately. Further, since the sample S does not fluctuate, observation can be performed in a stable state.
  • FIG. 9 shows an example of an image obtained from the image sensor 11 when photographing is performed without the cover member 4 attached.
  • FIG. 10 shows an example of an image obtained from the image sensor 11 when photographing is performed with the cover member 4 attached.
  • FIG. 11 shows an example of the structure of the cover member 4 according to the first modification when it is attached to the imaging device 1 and viewed from above.
  • FIG. 12 shows an example of the state of the sample S when the cover member 4 according to the first modification is attached to the imaging device 1.
  • the cover member 4 according to the first modification has a drainage channel 4B through which a portion of the sample S that becomes surplus when the sample S is held down by the holding part 4A is discharged to the outside. We are prepared.
  • each drainage channel 4B is provided at the edge portion of the holding portion 4A and the portion that contacts the hook portion 1C. It is designed not to enter the area.
  • the excess sample S can be easily and efficiently discharged from each location when the cover member 4 is pushed down.
  • photographing of the sample S can be prevented from being adversely affected.
  • FIG. 13 shows an example of the state of the sample S when the cover member 4 according to Modification 2 is attached to the imaging device 1.
  • the structure of the cover member 4 shown in FIG. 13 corresponds to the structure of the cover member 4 explained in FIGS. 7 and 8.
  • the hook portion 1C has two steps in the shape of a step, as described above. That is, in addition to the first stage hook part 1C, there is a second stage hook part 1D above it.
  • the cover member 4 according to the second modification can be attached to the imaging device 1 of the type that has a plurality of hook portions. Further, as described above, since there is no need to increase the vertical thickness of the holding portion 4A, there is an advantage that the sharpness of the image is not reduced and it is light and easy to carry.
  • the sample S can be placed within the depth of field x of the image sensor 11, and a clear image can be obtained.
  • the sample S can be made to fall within the range of the depth of field x of the image sensor 11, and a clear image can be obtained.
  • FIG. 14 shows an example of an image of sample S before drying.
  • FIG. 15 shows an example of an image after drying the sample S.
  • a cover member 4 is used here in order to obtain a clear image.
  • step S11 a specified amount of the sample S is measured (step S11), and the specified amount of the sample S is dropped into the sample mounting space 1A above the image sensor 11 (step S12).
  • the cover member 4 is placed on the imaging device 1, and the surface of the sample S placed in the sample placement space 1A on the image sensor 11 is flattened (step S13).
  • the illumination 5 is installed above the cover member 4 so that the light from the illumination 5 passes through the cover member 4 and illuminates the sample S (step S14).
  • Step S15 the sample S is photographed and the image output from the image sensor 11 is acquired by the information processing device 2, the acquired image is displayed on the display device, and microorganisms, etc. contained in the sample S are observed from the image.
  • the sample S is dried in order to obtain a clear image.
  • a specified amount of sample S is measured (step S21), and the specified amount of sample S is dropped into the sample placement space 1A above the image sensor 11 (step S22).
  • the illumination 5 is installed above the cover member 4 so that the light from the illumination 5 illuminates the sample S (step S24).
  • Step S25 the sample S is photographed and the image output from the image sensor 11 is acquired by the information processing device 2, the acquired image is displayed on the display device, and microorganisms, etc. contained in the sample S are observed from the image.

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Sustainable Development (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Optics & Photonics (AREA)
  • Optical Elements Other Than Lenses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Un élément de couvercle de capteur d'image (4) selon un mode de réalisation comprend une partie de pression (4A) qui presse la surface d'un échantillon liquide (S) placé dans un espace de placement d'échantillon (1A) au-dessus d'un capteur d'image (11) inclus dans un dispositif d'imagerie (1) de telle sorte que la surface de l'échantillon (S) devient plate.
PCT/JP2023/003218 2022-09-22 2023-02-01 Élément de couvercle de capteur d'image, système d'observation et procédé d'observation WO2024062641A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2022-150871 2022-09-22
JP2022150871A JP2024045838A (ja) 2022-09-22 2022-09-22 イメージセンサーのカバー部材、観察システム、および観察方法

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WO2024062641A1 true WO2024062641A1 (fr) 2024-03-28

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0943127A (ja) * 1995-07-28 1997-02-14 Shimadzu Corp 粒状体の圧縮試験装置
JP2010054426A (ja) * 2008-08-29 2010-03-11 Toyobo Co Ltd 疾患の観察方法
JP2019500871A (ja) * 2015-12-28 2019-01-17 キアジェン サイエンシズ，リミティド ライアビリティ 薄膜フローセル
JP2020041928A (ja) * 2018-09-11 2020-03-19 株式会社東芝 セルフチェックシステム
JP2021501322A (ja) * 2017-10-26 2021-01-14 エッセンリックス コーポレーション 血小板の高速測定法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0943127A (ja) * 1995-07-28 1997-02-14 Shimadzu Corp 粒状体の圧縮試験装置
JP2010054426A (ja) * 2008-08-29 2010-03-11 Toyobo Co Ltd 疾患の観察方法
JP2019500871A (ja) * 2015-12-28 2019-01-17 キアジェン サイエンシズ，リミティド ライアビリティ 薄膜フローセル
JP2021501322A (ja) * 2017-10-26 2021-01-14 エッセンリックス コーポレーション 血小板の高速測定法
JP2020041928A (ja) * 2018-09-11 2020-03-19 株式会社東芝 セルフチェックシステム

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