WO2024043028A1 - シリンジシステム及びシリンジシステムの使用方法 - Google Patents

シリンジシステム及びシリンジシステムの使用方法 Download PDF

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Publication number
WO2024043028A1
WO2024043028A1 PCT/JP2023/028381 JP2023028381W WO2024043028A1 WO 2024043028 A1 WO2024043028 A1 WO 2024043028A1 JP 2023028381 W JP2023028381 W JP 2023028381W WO 2024043028 A1 WO2024043028 A1 WO 2024043028A1
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WO
WIPO (PCT)
Prior art keywords
syringe
needle
needle guide
holder
syringe system
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2023/028381
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English (en)
French (fr)
Japanese (ja)
Inventor
悠 森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyocera Corp
Original Assignee
Kyocera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyocera Corp filed Critical Kyocera Corp
Priority to JP2024542713A priority Critical patent/JPWO2024043028A1/ja
Priority to US18/872,659 priority patent/US20250288733A1/en
Publication of WO2024043028A1 publication Critical patent/WO2024043028A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/029—Separating blood components present in distinct layers in a container, not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers

Definitions

  • the present disclosure relates to syringe systems and methods of using syringe systems.
  • Patent Document 1 discloses a device for fractionating blood (platelet-rich plasma collection device).
  • a syringe system includes a first syringe, a first needle guide, and a first holder.
  • the first syringe has a first needle.
  • the first needle guide has a first hole in which the first needle is located and which is shorter than the length of the first needle in the longitudinal direction.
  • the first holder fixes the first syringe and the first needle guide at a specific interval. The specific interval is longer than the difference between the length of the first needle and the length of the first hole.
  • a method of using the syringe system includes inserting the first needle guide into the second syringe barrel with the first holder fixing the first syringe and the first needle guide at a specific interval. , with the first needle guide located inside the second syringe cylinder, release the first holder from the first syringe and the first needle guide, and remove the first holder from the first syringe and the first needle guide.
  • the distance between the first syringe and the first needle guide is made shorter than a specific interval in a state where the fixation is released.
  • the specific interval is larger than the difference between the length of the first hole of the first needle guide and the length of the first needle of the first syringe, and the length in the longitudinal direction of the first needle is the length in the longitudinal direction of the first hole. It's longer than Sayori.
  • FIG. 1 is an overall view of a syringe system 100.
  • FIG. 2 is a cross-sectional view of the syringe system 100 taken along line AA shown in FIG. 1.
  • FIG. 2 is a diagram showing a state in which the first syringe 10 and the first needle guide 20 are moved perpendicularly to the longitudinal direction from FIG. 1 regarding the syringe system 100.
  • FIG. FIG. 3 is a front view of the first holder 30 in three directions.
  • 3 is an overall view of a syringe system 100 including a second syringe 40.
  • FIG. 6 is a cross-sectional view of the syringe system 100 including the second syringe 40 taken along the line AA shown in FIG. 5.
  • FIG. 2 is a diagram showing an example of a process flow for producing PRP from blood using the syringe system 100.
  • FIG. 2 is an overall view of a syringe system 200.
  • 9 is a cross-sectional view of the syringe system 200 taken along line AA shown in FIG. 8.
  • FIG. FIG. 2 is a diagram showing an example of a process flow for producing PRP from blood using a syringe system 200.
  • 3 is an overall view of a syringe system 300.
  • FIG. 12 is a cross-sectional view of the syringe system 300 taken along the line AA shown in FIG. 11.
  • FIG. FIG. 4 is an overall view of a syringe system 400.
  • FIG. 14 is a cross-sectional view of the syringe system 400 taken along the line AA shown in FIG. 13.
  • FIG. FIG. 5 is an overall view of a syringe system 500.
  • 16 is a cross-sectional view of the syringe system 500 taken along the line AA shown in FIG. 15.
  • FIG. It is a diagram showing an example of the configuration of a syringe system 600.
  • FIG. 6 is a diagram showing an example of the second half of the flow of processing for producing PRP from blood using the syringe system 600.
  • the syringe system 100 separates a specific component from among a plurality of components having different specific gravities in a liquid sample.
  • the syringe system 100 is used to separate platelet rich plasma (PRP) from blood as a liquid sample by centrifugation.
  • PRP platelet rich plasma
  • the present invention is not limited thereto, and the syringe system 100 can also be used to prepare samples using a plurality of syringes.
  • an operator can use the syringe system 100 to separate only a specific phase after extracting a specific component from an aqueous sample using an organic solvent.
  • FIG. 1 is an overall view of a syringe system 100.
  • FIG. 2 shows the internal structure of the syringe system 100.
  • the operator can fractionate the liquid by storing the liquid contained in another syringe or the like into the syringe system 100.
  • the centrifuged liquid contained in other syringes may be contained within the syringe system 100.
  • the components of the syringe system 100 that use plastic materials can be formed by injection molding, extrusion molding, or compression molding.
  • the syringe system 100 includes a first syringe 10, a first needle guide 20, and a first holder 30.
  • the first syringe 10 has a first needle 11.
  • the first needle guide 20 has a first hole 21 in which the first needle is located and which is shorter than the length of the first needle in the longitudinal direction.
  • the first holder 30 fixes the first syringe 10 and the first needle guide 20 at a specific interval L.
  • the specific interval L is longer than the difference between the length L1 of the first needle 11 and the length L2 of the first hole 21.
  • the syringe system 100 may further include a second syringe 40, as shown in FIGS. 5 and 6.
  • the second syringe 40 has a second needle 41 and a second sealing 45.
  • the first syringe 10 can store liquid.
  • the first syringe 10 can store a predetermined component among the plurality of fractionated components in the second syringe 40 .
  • the first syringe 10 has a first needle 11 extending in the longitudinal direction.
  • the longitudinal direction is approximately the height direction of the cylindrical shape of the first syringe 10, and corresponds to the direction in which the line AA in FIG. 1 extends.
  • the first syringe 10 may include a first syringe barrel 12 connected to the first needle 11, a first gasket 13 positionable within the first syringe barrel 12, and a first plunger 14.
  • the first needle 11 can move the liquid stored in the second syringe 40 to the first syringe 10.
  • the first needle 11 may be detachable from the first syringe barrel 12.
  • the first needle 11 has a cylindrical shape.
  • the first needle may be formed so that a portion thereof forms an acute angle or an obtuse angle.
  • a metal material such as iron or stainless steel can be used as the material of the first needle 11.
  • the connecting portion of the first needle 11 with the first syringe barrel 12 may be formed of polyethylene, polypropylene, polytetrafluoroethylene, polycarbonate, or the like.
  • the first syringe barrel 12 stores the liquid transferred through the first needle 11 inside. Further, the first syringe barrel 12 can function as a handle portion when the operator operates the first syringe 10.
  • the first syringe barrel 12 has a cylindrical region.
  • the first syringe barrel 12 can store liquid in a space inside a cylindrical region.
  • the first syringe barrel 12 may have a convex region protruding from one side of the cylindrical region.
  • the space inside the convex region is connected to the space inside the cylindrical region.
  • the space inside the convex region communicates with the space inside the first needle 11 .
  • the convex region of the first syringe barrel 12 and the first needle 11 may be detachable.
  • polyethylene, polypropylene, polymethyl methacrylate, polyethylene terephthalate, polycarbonate, or the like can be used as the material for each component of the first syringe barrel 12.
  • the first gasket 13 is located inside the first syringe barrel 12 and moves back and forth within the first syringe barrel 12. For example, the first gasket 13 may be moved back and forth by the operator using the first plunger 14. By reciprocating within the first syringe barrel 12, the first gasket 13 allows liquid to be introduced into the first syringe barrel 12 via the first needle 11, and to introduce the liquid to the outside of the first syringe barrel 12. can be discharged.
  • the first gasket 13 may have a concave region to which the first plunger 14 can be attached.
  • natural rubber styrene-butadiene rubber, acrylonitrile rubber, butyl rubber, chloroprene rubber, ethylene propylene rubber, isoprene rubber, urethane rubber, silicone rubber, or fluororubber can be used as the material for the first gasket 13.
  • the first plunger 14 is a rod-shaped member. By operating the first plunger 14, the operator can introduce the liquid into the first syringe barrel 12 and discharge the liquid to the outside of the first syringe barrel 12. By operating the first plunger 14, the first gasket 13 is reciprocated, liquid is introduced into the first syringe barrel 12 through the first needle 11, and liquid is introduced outside the first syringe barrel 12. can be discharged.
  • the first plunger 14 is attached to the first gasket 13.
  • the first plunger 14 and the first gasket 13 are removable.
  • the tip of the first plunger 14 may have a structure capable of engaging with a hole in the first gasket 13, or a screw structure, for example. good.
  • the tip of the first plunger 14 has a threaded structure
  • the hole of the first gasket 13 has a threaded hole structure.
  • the first plunger 14 may be made of polycarbonate, polypropylene, polymethyl methacrylate, polyethylene terephthalate, or the like.
  • the syringe system 100 may include a first sealing 15 that can be attached to the port portion of the first syringe barrel 12 after the first needle 11 is removed from the first syringe 10.
  • the first sealing 15 is attached to a convex region of the first syringe barrel 12 when the first syringe barrel 12 is used as a centrifuge container.
  • the first syringe 10 can function as a centrifugal separation container by attaching the first sealing 15 to the port portion of the first syringe barrel 12. By using the first sealing 15, the operator can centrifuge the liquid while the liquid is contained in the first syringe barrel 12.
  • natural rubber styrene-butadiene rubber, acrylonitrile rubber, butyl rubber, chloroprene rubber, ethylene propylene rubber, isoprene rubber, urethane rubber, silicone rubber, fluororubber, or the like can be used.
  • the first needle guide 20 can accommodate the first needle 11 therein.
  • the first needle guide 20 may function as a guide for moving the first needle 11 when the first syringe 10 is operated.
  • the first needle guide 20 is located at a position moved a predetermined distance from the first syringe 10 in the longitudinal direction.
  • the first needle guide 20 is located on the first needle 11 side with respect to the first syringe barrel 12 in the longitudinal direction.
  • the first needle guide 20 has a first hole 21 that passes through the first needle guide 20 in the longitudinal direction.
  • the first needle guide 20 is located at the end on the first syringe 10 side and has a first plate 22 extending from the outer surface.
  • the first needle guide 20 has a second plate 23 located at a predetermined distance from the first plate 22 in the longitudinal direction and extending from the outer surface.
  • the cross section of the first needle guide 20 perpendicular to the longitudinal direction may be circular, square, or cross-shaped. In this embodiment, the cross section perpendicular to the longitudinal direction of the first needle guide 20 is circular.
  • the material for the first needle guide 20 polycarbonate, polypropylene, polymethyl methacrylate, polyethylene terephthalate, or the like can be used.
  • the first hole 21 can accommodate the first needle 11 therein.
  • the first hole 21 accommodates the first needle 11 therein.
  • the length of the first hole 21 in the longitudinal direction is longer than the length of the first needle 11 in the longitudinal direction.
  • the diameter of the first hole 21 is larger than the diameter of the first needle 11.
  • the diameter of the first hole 21 is smaller than the diameter of the first syringe barrel 12.
  • the first hole 21 penetrates the first needle guide 20.
  • the first hole 21 may be located at the center of the first needle guide 20 in a cross section perpendicular to the longitudinal direction.
  • the first hole 21 has a first open end 24 located on the first syringe 10 side and a second open end 25 located on the opposite side of the first open end 24.
  • the sizes of the first open end 24 and the second open end 25 may be the same or different.
  • the first hole 21 is cylindrical. In this embodiment, the first hole 21 has a cylindrical shape.
  • the first open end 24 and the second open end 25 are circular.
  • the first plate 22 and the second plate 23 can function as a handle portion when the operator operates the first needle guide 20.
  • the first plate 22 may function as a handle portion when the operator operates the first syringe and the first needle guide 20 at the same time.
  • the first plate 22 and the second plate 23 may be plate-shaped. Further, the second plate 23 is not necessarily essential.
  • the first holder 30 fixes the distance between the first syringe 10 and the first needle guide 20 at a specific distance L.
  • FIG. 3 shows the positional relationship in the longitudinal direction of the first holder 30, the first syringe 10, and the first needle guide 20, and the length of each part.
  • FIG. 3 is a diagram showing a state in which the first syringe 10 and the first needle guide 20 have been moved perpendicularly to the longitudinal direction from the states shown in FIGS. 1 and 2.
  • the specific interval L is greater than or equal to the difference (L1-L2) between the length L1 of the first needle 11 and the length L2 of the first hole 21, and less than or equal to the length L1 of the first needle 11.
  • the specific interval L is a length that satisfies the relationship “L1 ⁇ L ⁇ (L1 ⁇ L2)”.
  • the distance between the first syringe 10 and the first needle guide 20 is defined as (i) the first needle guide 20 of the first syringe barrel 12 in the longitudinal direction of the first syringe 10 and the first needle guide 20; and (ii) the end of the first needle guide 20 on the first syringe 10 side.
  • the first holder 30 fixes the first needle 11. By fixing the first needle 11 with the first holder 30, it is possible to reduce the possibility that the first needle 11 will be exposed from the second open end 25 of the first hole 21.
  • the first holder 30 may function as a handle portion when the operator operates the first syringe 10 and the first needle guide 20.
  • the first holder 30 includes a first portion 31, a second portion 32 located on the first needle guide 20 side with respect to the first portion 31, the first portion 31, and the second portion 32. and a base 33 located between.
  • the length L3 between the end of the first portion 31 on the first needle guide 20 side in the longitudinal direction and the end of the second portion 32 on the first syringe 10 side is longer than the specific interval L.
  • the first holder 30 can fix the distance between the first syringe 10 and the first needle guide 20 at a specific distance L.
  • the first holder 30 has a recess 34 formed by a first portion 31, a second portion 32, and a base 33, as shown in FIG.
  • polycarbonate, polypropylene, polymethyl methacrylate, polyethylene terephthalate, or the like can be used as the material for the first holder 30.
  • the first portion 31 fixes the first needle guide 20.
  • the first portion 31 is located between the first plate 22 and the second plate 23 of the first needle guide 20.
  • the first portion 31 has an arc shape in a cross section perpendicular to the longitudinal direction. Since the first portion 31 has this configuration, the operator can easily release the fixation by the first holder 30.
  • the shape of the first portions 431A, 431B in a cross section perpendicular to the longitudinal direction is not limited to a circular arc, but may be L-shaped or U-shaped.
  • the central angle of the arc in the cross section perpendicular to the longitudinal direction of the first portion 31 is 180° or more and 360° or less.
  • the inner diameter of the first portion 31 is less than or equal to the outer diameter of the first needle guide 20. By having this configuration, the first portion 31 can firmly fix the first needle guide 20.
  • the first portion 31 has a first opening 35 consisting of two arc-shaped ends.
  • the width of the first opening 35 is less than or equal to the inner diameter of the first portion 31 .
  • the inner surface of the first portion 31 is in contact with the first needle guide 20.
  • the inner surface of the first portion 31 may have a shape that follows the outer surface of the first needle guide 20.
  • the second portion 32 fixes the first syringe 10.
  • the second portion 32 fixes the first needle 11 of the first syringe 10.
  • the second portion 32 is located between the first syringe barrel 12 and the first needle guide 20.
  • the length L4 of the second portion 32 in the longitudinal direction is equal to or larger than the specific interval L.
  • the second portion 32 has an arc shape in a cross section perpendicular to the longitudinal direction. With the second portion 32 having this configuration, the operator can easily release the fixation by the first holder 30.
  • the central angle of the arc in the cross section perpendicular to the longitudinal direction of the second portion 32 is 180° or more and 360° or less.
  • the inner diameter of the second portion 32 is less than or equal to the outer diameter of the first syringe 10. With this configuration, the second portion 32 can firmly fix the first syringe 10 because the inside of the second portion 32 presses the first syringe 10.
  • the inner diameter of the second portion 32 is less than or equal to the outer diameter of the first syringe barrel 12 and the outer diameter of the first needle guide 20. By having this configuration, the second portion 32 can prevent the first syringe 10 and the first needle guide 20 from moving toward each other.
  • the second portion 32 has a second opening 36 consisting of two arc-shaped ends.
  • the width of the second opening 36 is less than or equal to the inner diameter of the second portion 32. With the second opening 36 having this configuration, it is possible to reduce the risk that the first syringe 10 will be unfixed by the first holder 30.
  • the inner surface of the second portion 32 abuts the first syringe 10 .
  • the inner surface of the second portion 32 may have a shape that follows the outer surface of the first syringe 10.
  • the base 33 connects the first part 31 and the second part 32.
  • the base portion 33 may function as a handle portion when an operator operates the first holder 30.
  • the base portion 33 may be formed integrally with the first portion 31 and the second portion 32.
  • the base 33 is plate-shaped.
  • the base 33 may be rod-shaped.
  • the recess 34 includes a space located between the first portion 31 and the second portion 32.
  • the first plate 22 can be located inside the recess 34 . Since the first plate 22 is located inside the recess 34, when the first needle guide 20 attempts to move in the longitudinal direction, the first portion 31 and the second portion 32 move the first needle guide 20. can be inhibited.
  • the syringe system 100 can improve safety when an operator operates the syringe system 100.
  • the first syringe and the first needle guide are provided in an uncombined state.
  • the first needle of the first syringe is provided with a cap attached.
  • the operator had to remove the cap of the first needle and then combine the first syringe and first needle guide himself. Therefore, there has been a problem in that safety when an operator operates the syringe system is low.
  • the operator removes the cap of the first needle and assembles the first syringe and first needle guide, there is a risk that the first needle may accidentally stick into the hand or finger.
  • the first syringe and first needle guide are provided in combination to solve the above problem, there is a risk that the first needle will be exposed from the second open end of the first needle guide. Ta.
  • the syringe system 100 includes the first holder 30 that fixes the first syringe 10 and the first needle guide 20 at a specific interval L, as described above.
  • the specific interval L is greater than or equal to the difference (L1-L2) between the length L1 of the first needle 11 and the length L2 of the first hole 21. This can reduce the risk that the first needle 11, which is longer than the first hole 21, will be exposed from the second open end 25 of the first hole 21, thereby increasing safety when the operator operates the syringe system 100. can be improved.
  • the specific interval L is equal to or less than the length L1 of the first needle 11. This can reduce the risk of the first needle being exposed from the first open end 24 of the first hole 21, and can improve safety when the operator operates the syringe system 100.
  • the syringe system 100 may further include a second syringe 40, as shown in FIGS. 5 and 6.
  • the second syringe 40 can store a liquid sample.
  • the second syringe 40 can fractionate a plurality of components having different specific gravities in a liquid sample by centrifugation or the like.
  • the second syringe 40 has a second syringe barrel 42.
  • the second syringe 40 may include a second needle 41 that is detachable from the second syringe barrel 42, a second gasket 43 that is positionable within the second syringe barrel 42, a second plunger 44, and a second sealing 45. good.
  • the second syringe barrel 42 stores the liquid transferred through the second needle 41 inside.
  • the first needle guide 20 can be positioned inside the second syringe barrel 42 .
  • the second syringe barrel 42 may have the same structure as the first syringe barrel 12.
  • the second needle 41 may have the same structure and function as the first needle 11.
  • the second gasket 43 may have the same structure and function as the first gasket 13.
  • the second plunger 44 may have the same structure and function as the first plunger 14.
  • the second sealing 45 may have the same structure and function as the first sealing 15.
  • FIG. 7 is a diagram showing an example of the flow of producing PRP from blood using the syringe system 100 shown in FIGS. 5 and 6.
  • Blood collection process ⁇ 1a> The operator uses the second syringe 40 to collect blood from the patient. The operator removes the second needle 41 from the second syringe barrel 42 and attaches the second sealing 45. The operator removes the second plunger 44 from the second gasket 43. ⁇ 1a> shows a state in which collected blood is stored in the second syringe 40 and the second sealing 45 is attached to the second syringe barrel 42.
  • First centrifugation treatment step ⁇ 2a> The operator uses the second syringe 40 as a centrifugal separation container, and a centrifugal separation process is performed using centrifugal force directed from the second gasket 43 side to the second sealing 45 side.
  • the conditions for the centrifugal separation process can be set by the operator according to the usage environment of the syringe system 100, and may be, for example, a centrifugal acceleration of 600 ⁇ g and a processing time of 7 minutes.
  • the liquid in the second syringe barrel 42 is divided into a heavy layer P1 containing red blood cells and a light layer P2 containing more platelets than layer P1.
  • ⁇ 2a> shows the state of the second syringe 40 and the liquid within the second syringe 40 after the centrifugal separation process.
  • First assembly process ⁇ 3a> The operator inserts the first needle guide 20 into the second syringe cylinder 42 with the first syringe 10 and the first needle guide 20 being fixed by the first holder 30. The operator attaches the first needle guide 20 to the second gasket 43.
  • ⁇ 3a> shows a state in which the first needle guide 20 of the syringe system 100 is attached to the second gasket 43.
  • First release step ⁇ 4a> The operator removes the first holder 30 from the first syringe 10 and first needle guide 20. By removing the first holder 30 from the first syringe 10 and the first needle guide 20, the first syringe 10 becomes movable in the longitudinal direction with respect to the first needle guide 20.
  • ⁇ 4a> shows a state in which the first holder 30 of the syringe system 100 is removed from the first syringe 10 and the first needle guide 20.
  • First insertion step ⁇ 5a> The operator moves the first syringe 10 so that the distance between the first syringe 10 and the first needle guide 20 in the longitudinal direction becomes shorter.
  • the length L1 of the first needle 11 is such that when the first syringe 10 and the first needle guide 20 are brought into contact, the end of the first needle 11 penetrates the bottom of the second gasket 43; It is set to be exposed to layer P2.
  • ⁇ 5a> shows a state in which the first holder 30 of the syringe system 100 is removed and the first syringe 10 and the first needle guide 20 are in contact.
  • First extraction step ⁇ 6a> The operator moves the first plunger 14 in a direction to pull it out from the first syringe barrel 12. Alternatively, the operator pushes the first syringe barrel 12 down toward the second syringe with respect to the first plunger 14. As a result, the first gasket 13 moves and the layer P2 is accommodated in the first syringe 10. Through this operation, the operator can separate the layer P2 fractionated from the blood into the first syringe 10. ⁇ 6a> shows a state in which the layer P2 is separated into the first syringe 10.
  • First separation step ⁇ 7a> The operator removes the first needle 11 from the first syringe barrel 12 in ⁇ 6a>. Thereby, the operator can use the first syringe 10 containing the layer P2 for subsequent operations without pulling it out from the first needle guide 20. For example, by attaching the first sealing 15 to the tip of the first syringe 10, the operator can use the first gasket 13 side to make the first syringe 10 a centrifugation container for further fractionation operation of the layer P2. A centrifugal separation process can be performed using centrifugal force directed toward the first sealing 15 side.
  • ⁇ 7a> shows a state in which the first needle 11 is removed from the first syringe barrel 12.
  • the above fractionation operation is performed by inserting the first needle guide 20 into the second syringe barrel 42 with the first holder 30 fixing the first syringe 10 and the first needle guide 20 at a specific interval L, and then With the first needle guide 20 located inside the second syringe barrel 42, the first syringe 10 and the first needle guide 20 are released from the first holder 30, and the first syringe 10 and the first
  • This is a method of using a syringe system in which the distance between the first syringe 10 and the first needle guide 20 is made shorter than a specific distance L while the needle guide 20 is released from being fixed by the first holder 30.
  • the specific interval L is greater than or equal to the difference between the length L1 of the first needle 11 of the first syringe 10 and the length L2 of the first hole 21 of the first needle guide 20, and The length L1 in the longitudinal direction is longer than the length L2 of the first hole 21 in the longitudinal direction.
  • an example of a step of inserting the first needle guide 20 into the second syringe barrel 42 with the first holder 30 fixing the first syringe 10 and the first needle guide 20 at a specific interval L. is the first assembly process described above.
  • An example of the step of releasing the fixation by the first holder 30 from the first syringe 10 and the first needle guide 20 in a state where the first needle guide 20 is located inside the second syringe barrel 42 is the first example described above. This is a release process.
  • An example of a process of making the distance between the first syringe 10 and the first needle guide 20 shorter than the specific interval L with the first syringe 10 and the first needle guide 20 released from the first holder 30. is the first insertion step described above.
  • the operator can operate the syringe system 100 without exposing the first needle 11 to the outside, thereby improving safety when the operator uses the syringe system 100. I can do it.
  • the operator can produce PRP from blood without exposing the first needle 11 to the outside.
  • FIG. 8 is an overall view of the syringe system 200.
  • FIG. 9 shows the internal structure of the syringe system 200.
  • the syringe system 200 is different from the syringe system 100 in the structure and function of the first holder 230.
  • the first holder 230 fixes the first syringe barrel 12 of the first syringe 10 and the first needle guide 20. By having this configuration, the first holder 230 can stabilize the first syringe 10 when the operator operates the syringe system 200.
  • the first holder 230 can shorten the distance between the first syringe 10 and the first needle guide 20 from the specific distance L while the first syringe 10 and the first needle guide 20 are fixed. Further, when the distance between the first syringe 10 and the first needle guide 20 is shorter than the specific interval L, the first holder 230 is moved in the direction in which the distance between the first syringe 10 and the first needle guide 20 increases. force can be applied to.
  • the second portion 232 fixes the first syringe barrel 12.
  • the second portion 232 fixes a convex region protruding from one side of the cylindrical region of the first syringe barrel 12 .
  • the second portion 232 fixes the convex region of the first syringe barrel 12
  • the first syringe 10 and the first needle guide 20 move in the direction toward each other
  • the second portion 232 and the first needle guide 20 move toward each other. 1.
  • the bottoms of the syringe barrels 12 come into contact. Therefore, the first holder 230 having this configuration can reduce the risk of the first needle 11 being exposed.
  • the second portion 232 may fix the cylindrical portion of the first syringe barrel 12 .
  • wobbling of the first syringe 10 when the operator operates the syringe system 200 can be further reduced.
  • the base 233 can be expanded and contracted in the longitudinal direction.
  • the base portion 233 can elastically apply force to the first portion 231 and the second portion 232 in the longitudinal direction.
  • the base 233 when the distance between the first syringe 10 and the first needle guide 20 is shorter than the specific distance L, the base 233 is arranged in a longitudinal direction so that the distance between the first part 231 and the second part 232 becomes longer. You may also apply force in the direction.
  • the base 233 is configured to separate the first syringe 10 and the first needle guide 20 from each other with respect to the first portion 231 and the second portion 232. A force may be applied in a direction to bring the distance closer to the specific distance L.
  • the base 233 may be formed of a coil spring, a plate spring, or the like.
  • FIG. 10 is a diagram showing an example of the flow of producing PRP from blood using the syringe system 200 shown in FIGS. 8 and 9.
  • the blood collection process ⁇ 1b> to the first assembly process ⁇ 3b> are the same as or similar to ⁇ 1a> to ⁇ 3a> in the syringe system 100, and therefore their description will be omitted.
  • the first extraction step ⁇ 5b> is the same as or similar to the first extraction step ⁇ 6a> in the syringe system 100, except that the first holder 230 is attached, so the description thereof will be omitted.
  • First insertion step ⁇ 4b> The operator holds the first syringe 10 and the first needle guide 20 in a fixed state with the first holder 230, and the distance between the first syringe 10 and the first needle guide 20 in the longitudinal direction is short. Move the first syringe 10 so that the ⁇ 4b> shows a state in which the first syringe 10 and the first needle guide 20 are in contact with the first holder 230 of the syringe system 200.
  • First separation step ⁇ 6b> The operator returns the distance between the first syringe 10 and the first needle guide 20 to the specific distance L while the first holder 230 keeps the first syringe 10 and the first needle guide 20 fixed. . ⁇ 6b> shows the state after the distance between the first syringe 10 and the first needle guide 20 is returned to the specific distance L.
  • the operator removes the first holder 230 from the first syringe 10 and the first needle guide 20, and removes the first syringe 10 containing the layer P2 from subsequent operations. It can be used for.
  • the operator can use the first syringe 10 to administer layer P2 to the subject.
  • the operator may replace the first needle 11 with another needle before administering the layer P2.
  • the operator can discard it without removing the first needle guide 20 from the first syringe 10 after the first separation step ⁇ 6b>.
  • the first needle 11 of the first syringe 10 can be disposed of without being exposed, so that safety when the operator uses the syringe system 200 can be improved.
  • FIG. 11 is an overall view of the syringe system 300.
  • FIG. 12 shows the internal structure of the syringe system 300.
  • the syringe system 300 is different from the syringe system 100 in the structure and function of the first holder 330.
  • the first holder 330 fixes the first syringe barrel 12 of the first syringe 10, the first needle 11, and the first needle guide 320.
  • the first holder 230 can reduce the wobbling of the first syringe 10 when the operator operates the syringe system 300, and can also strengthen the fixation by the first holder 330. can.
  • the second portion 332 of the first holder 330 fixes the first needle 11.
  • the first holder 330 has a third portion 337 that fixes the first syringe barrel 12.
  • the third portion 337 has an arc shape in a cross section perpendicular to the longitudinal direction.
  • the central angle of the arc in the cross section perpendicular to the longitudinal direction of the third portion 337 is 180° or more and 360° or less.
  • the inner diameter of the third portion 337 is less than or equal to the outer diameter of the first syringe barrel 12 .
  • the third portion 337 has a third opening 338 consisting of two arc-shaped ends.
  • the width of the third opening 338 is less than or equal to the inner diameter of the third portion 337.
  • the inner surface of the third portion 337 is in contact with the first syringe barrel 12 .
  • the inner surface of the third portion 337 may have a shape that follows the outer surface of the first syringe barrel 12.
  • the first holder 330 has a grip portion 339 that can be gripped by the operator.
  • the grip portion 339 extends from the base portion 333 of the first holder 330 .
  • the grip portion 339 may extend from a portion other than the base portion 333 of the first holder 330.
  • the grip portion 339 extends on the side opposite to the first syringe 10 with respect to the base portion 333 .
  • the grip portion 339 may be removably attached to the base portion 333.
  • the first holder 330 may have a plurality of gripping parts 339.
  • the inner surface of the first portion 331 is a contact surface with the first needle guide 320. Further, the inner surface of the first portion 331 has a first convex portion 331A that comes into contact with the outer surface of the first needle guide 320.
  • the first convex portion 331A may be located only on a part of the inner surface of the first portion 331.
  • the first convex portion 331A may be located along the inner peripheral surface of the first portion 331.
  • the first convex portion 331A may be located parallel to the end of the first portion 331 on the first syringe 310 side.
  • the first needle guide 320 has a first recess 320B that can engage with the first protrusion 331A.
  • the syringe system 300 can firmly fix the first holder 330 and the first needle guide 320.
  • the first needle guide 20 may have the first protrusion 331A, and the first portion 331 may have the first recess 320B.
  • the inner surface of the second portion 332 or the inner surface of the third portion 337 has a second convex portion 332B or a third convex portion 337A, which is the same as or similar to the first portion 331.
  • the first needle 311 or the first syringe barrel 312 may have a second recess 311B or a third recess 312B, which is the same as or similar to the first needle guide 320.
  • FIG. 13 is an overall view of the syringe system 400.
  • FIG. 14 shows the internal structure of the syringe system 400.
  • the syringe system 400 is different from the syringe system 100 in the structure and function of the first holder 430.
  • the syringe system 400 has a first member 430A and a second member 430B as a first holder 430.
  • the first member 430A and the second member 430B each have first portions 431A, 431B, second portions 432A, 432B, and base portions 433A, 433B.
  • the first portions 431A, 431B can fit into each other.
  • the second portions 432A, 432B can fit together.
  • the first portions 431A and 431B can be fitted at their respective ends.
  • the first portion 431A has a convex shape at the end.
  • the first portion 431B has a concave shape at the end.
  • the convex shape of the first portion 431A and the concave shape of the first portion 431B can fit into each other.
  • the ends of the first portions 431A, 431B are not limited to a convex shape or a concave shape, and may have a structure in which a claw and a hole engage with each other, or a structure in which a hole is formed in each and is fixed with a screw or the like. good.
  • the central angle of the arc in the cross section perpendicular to the longitudinal direction of the first portions 431A, 431B is 180°.
  • the central angle of the circular arc in the cross section perpendicular to the longitudinal direction of the first portions 431A, 431B is not limited to 180°.
  • the central angle of the first portion 431A is 270°
  • the central angle of the first portion 431B is 90°. It may be °.
  • the second portions 432A and 432B have the same structure and function as the first portions 431A and 431B, respectively.
  • the structure of the second portions 432A, 432B and the structure of the first portions 431A, 431B may be different. For example, only the second portions 432A and 432B may be able to fit into each other. Only the first portions 431A, 431B may be able to fit into each other without the second portions 432A, 432B fitting together.
  • FIG. 15 is an overall view of the syringe system 500.
  • FIG. 16 shows the internal structure of the syringe system 500.
  • the syringe system 500 differs from the syringe system 100 in that it includes a cap 50 and a connecting member 60.
  • the cap 50 can cover the second open end 25 of the first needle guide 20.
  • the cap 50 is removably attached to the first needle guide 20.
  • the syringe system 500 reduces the risk of the end of the first needle 11 being exposed from the first hole 21, and improves safety when the operator operates the syringe system 500.
  • the syringe system 500 allows, for example, even if the fixation by the first holder 30 is unintentionally released, the end of the first needle 11 can be moved to the second open end of the first hole 21. The risk of exposure from 25 can be reduced.
  • the cap 50 has a protrusion 51 that is received from the second open end 25 into the first hole 21 .
  • the material for the cap 50 butyl rubber, urethane rubber, fluororubber, silicone rubber, butadiene rubber, ethylene propylene rubber, acrylic rubber, or the like can be used.
  • the cap 50 has elasticity, and there is a risk that the cap 50 will come off when the first needle 11 tries to move toward the second open end 25 side. can be reduced. Therefore, by using the above materials as the material for the cap 50, safety when the operator operates the syringe system 500 is improved.
  • the protrusion 51 is accommodated into the first hole 21 from the second open end 25 and can partially fill the first hole 21 .
  • the protrusion 51 comes into contact with the first needle 11 .
  • the protrusion 51 may be deformable.
  • the protrusion 51 can apply force to the first needle 11 toward the first open end 24. Good too.
  • the cap 50 can reduce the risk of coming off from the first needle guide 20 as the first needle 11 moves toward the second open end 25 side.
  • the cap 50 Since the cap 50 has the protrusion 51, it is possible to reduce the risk that the first needle 11 will penetrate the cap 50 as the first needle 11 moves toward the second open end 25 side. Therefore, the cap 50 having the protrusion 51 improves safety when the operator operates the syringe system 500.
  • the connecting member 60 connects the first holder 30 and the cap 50.
  • the connecting member 60 is connected to the base 33 of the first holder 30.
  • the connecting member 60 is connected to the cap 50.
  • the connecting member 60 may be detachably attached to the first holder 30 or the cap 50.
  • the connecting member 60 may have elasticity.
  • silicone rubber, natural rubber, or the like can be used as the material for the connecting member 60.
  • FIG. 17 is a configuration example of a syringe system 600.
  • FIG. 18 shows an example of a liquid sample fractionation operation using the syringe system 600.
  • the syringe system 600 differs from the syringe system 100 in that it includes a third syringe 70, a second needle guide 80, and a second holder 90.
  • the third syringe 70 has the same structure and function as the first syringe 10.
  • the second needle guide 80 has the same structure and function as the first needle guide 20.
  • the second holder 90 has the same structure and function as the first holder 230.
  • the second holder 90 may have the same structure and function as the first holder 30, 330, 430.
  • the blood collection step ⁇ 1c> to the first separation step ⁇ 7c> are the same as or similar to the blood collection step ⁇ 1a> to the first separation step ⁇ 7a> in the syringe system 100, so their explanation will be omitted.
  • First installation process ⁇ 8c> The operator attaches the first sealing 15 to the first syringe 10 in which the layer P2 is stored. The operator removes the first plunger 14 from the first gasket 13. ⁇ 8c> shows a state in which the collected layer P2 is stored in the first syringe 10 and the first sealing 15 is attached to the first syringe barrel 12.
  • Second centrifugation step ⁇ 9c> The operator uses the first syringe 10 as a centrifugation container, and a centrifugal separation process is performed using centrifugal force directed from the first gasket 13 side to the first sealing 15 side.
  • the conditions for the centrifugal separation process can be set by the operator according to the usage environment of the syringe system 100, and may be, for example, a centrifugal acceleration of 2000 ⁇ g and a processing time of 5 minutes.
  • the liquid in the first syringe barrel 12 is divided into a layer P3 containing a higher concentration of platelets than the layer P2, and a layer P4 containing a lower concentration of platelets compared to the layer P2.
  • ⁇ 9c> shows the state of the first syringe 10 and the liquid within the first syringe 10 after the centrifugation process.
  • Second assembly process ⁇ 10c> The operator inserts the second needle guide 80 into the first syringe barrel 12 with the third syringe 70 and the second needle guide 80 being fixed by the second holder 90. The operator attaches the second needle guide 80 to the first gasket 13.
  • ⁇ 10c> shows a state in which the second needle guide 80 of the syringe system 600 is attached to the first gasket 13.
  • the second insertion step ⁇ 11c> to the second separation step ⁇ 13c> are the same as or similar to the first insertion step ⁇ 4b> to the first separation step ⁇ 6b> in the syringe system 200, so their explanation will be omitted.
  • the first syringe 10 in the syringe system 600 corresponds to a syringe in which patient's blood is stored and centrifuged in a blood fractionation operation using the syringe system 200 (see FIG. 10).
  • the third syringe 70 in the syringe system 600 corresponds to the first syringe 10 in the syringe system 200.
  • the second needle guide 80 in the syringe system 600 corresponds to the first needle guide 20 in the syringe system 200.
  • the second holder 90 in the syringe system 600 corresponds to the first holder 230 in the syringe system 200.
  • the layer P4 in the second insertion step ⁇ 11c> to the second separation step ⁇ 13c> corresponds to the layer P2 in the first insertion step ⁇ 4b> to the first separation step ⁇ 6b>.
  • First decomposition step ⁇ 14c> The operator removes the second needle guide 80 from the second gasket 43 with the third syringe 70 and the second needle guide 80 fixed to the second holder 90. A layer P3 is accommodated in the first syringe 10, and a layer P4 is accommodated in the third syringe 70. ⁇ 14c> shows the state after the second needle guide 80 is removed from the first gasket 13.
  • the operator can perform fractionation operations on a wider variety of liquid samples.
  • the operator can perform fractionation operations on a wider variety of liquid samples.

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PCT/JP2023/028381 2022-08-25 2023-08-03 シリンジシステム及びシリンジシステムの使用方法 Ceased WO2024043028A1 (ja)

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Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5415648A (en) * 1993-07-08 1995-05-16 Malay; Manuel R. Multiple purpose syringe
JPH11148924A (ja) * 1997-11-14 1999-06-02 Shimadzu Corp オートサンプラ
JP2008104789A (ja) * 2006-10-27 2008-05-08 Nipro Corp 多血小板血漿分離方法及び多血小板血漿分離装置
JP2011152353A (ja) * 2010-01-28 2011-08-11 Terumo Corp 薬剤投与具
JP2012161437A (ja) * 2011-02-04 2012-08-30 Nipro Corp 多血小板血漿分離キット及び多血小板血漿分離方法
WO2013140858A1 (ja) * 2012-03-23 2013-09-26 ニプロ株式会社 接続装置及び血液成分分離装置
JP2021177827A (ja) * 2020-05-11 2021-11-18 京セラ株式会社 シリンジシステム、多血小板血漿を調製する方法
US20210388304A1 (en) * 2020-06-16 2021-12-16 Saint-Gobain Performance Plastics Corporation Sampling system and method of using the same
WO2022085489A1 (ja) * 2020-10-23 2022-04-28 京セラ株式会社 シリンジシステム
WO2022224656A1 (ja) * 2021-04-22 2022-10-27 京セラ株式会社 筒体キットおよびガスケット

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5415648A (en) * 1993-07-08 1995-05-16 Malay; Manuel R. Multiple purpose syringe
JPH11148924A (ja) * 1997-11-14 1999-06-02 Shimadzu Corp オートサンプラ
JP2008104789A (ja) * 2006-10-27 2008-05-08 Nipro Corp 多血小板血漿分離方法及び多血小板血漿分離装置
JP2011152353A (ja) * 2010-01-28 2011-08-11 Terumo Corp 薬剤投与具
JP2012161437A (ja) * 2011-02-04 2012-08-30 Nipro Corp 多血小板血漿分離キット及び多血小板血漿分離方法
WO2013140858A1 (ja) * 2012-03-23 2013-09-26 ニプロ株式会社 接続装置及び血液成分分離装置
JP2021177827A (ja) * 2020-05-11 2021-11-18 京セラ株式会社 シリンジシステム、多血小板血漿を調製する方法
US20210388304A1 (en) * 2020-06-16 2021-12-16 Saint-Gobain Performance Plastics Corporation Sampling system and method of using the same
WO2022085489A1 (ja) * 2020-10-23 2022-04-28 京セラ株式会社 シリンジシステム
WO2022224656A1 (ja) * 2021-04-22 2022-10-27 京セラ株式会社 筒体キットおよびガスケット

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