WO2024021323A1 - 一种复合微针结构及神经微电极 - Google Patents

一种复合微针结构及神经微电极 Download PDF

Info

Publication number
WO2024021323A1
WO2024021323A1 PCT/CN2022/126570 CN2022126570W WO2024021323A1 WO 2024021323 A1 WO2024021323 A1 WO 2024021323A1 CN 2022126570 W CN2022126570 W CN 2022126570W WO 2024021323 A1 WO2024021323 A1 WO 2024021323A1
Authority
WO
WIPO (PCT)
Prior art keywords
needle
hard
soft
composite microneedle
composite
Prior art date
Application number
PCT/CN2022/126570
Other languages
English (en)
French (fr)
Inventor
黄立
黄晟
童贝
Original Assignee
武汉衷华脑机融合科技发展有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 武汉衷华脑机融合科技发展有限公司 filed Critical 武汉衷华脑机融合科技发展有限公司
Publication of WO2024021323A1 publication Critical patent/WO2024021323A1/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • A61B5/293—Invasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/262—Needle electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/294—Bioelectric electrodes therefor specially adapted for particular uses for nerve conduction study [NCS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053

Definitions

  • the invention relates to the field of brain-computer interface of biomedical engineering technology, and specifically relates to a composite microneedle structure and neural microelectrodes.
  • most invasive microneedle structures are single-type electrodes, such as Michigan electrodes and Utah electrodes with hard needle structures, and polyimide electrodes with soft needle structures.
  • Hard needles cannot adapt to the expansion and contraction of blood vessels during implantation, and may cause certain damage to the tissue; while soft needle structures are prone to deformation during implantation and require the use of external equipment to assist implantation. , but there are problems such as complex structure and low efficiency. The above two single types of needles cannot meet the current clinical needs.
  • the present invention provides a composite microneedle structure and neural microelectrodes, which can at least solve some of the problems existing in the prior art.
  • the present invention provides the following technical solutions:
  • a composite microneedle structure includes hard needles and soft needles.
  • a first connection part is arranged on the soft needle, and a second connection part is arranged on the hard needle.
  • the first connection part and the third connection part are arranged on the hard needle.
  • the two connecting parts are matched and connected to realize the combination of the hard needle and the soft needle.
  • the first connecting portion at the tail end of the soft needle it is preferable to configure the first connecting portion at the tail end of the soft needle to facilitate the combination of hard needles and soft needles.
  • the first connection part is preferably a patterned hole structure at the tail end of the soft needle.
  • the second connection part is preferably a plug structure arranged at a corresponding position of the hard needle to cooperate with the hole structure.
  • the plug structure arranged at the corresponding position of the hard needle and matched with the hole structure is realized by growth.
  • the hole structure is semi-closed.
  • the hole structure may be arc-shaped, rectangular or trapezoidal.
  • the plug structure can be cylindrical, rectangular columnar or trapezoidal columnar.
  • the number of the hole structures is at least one or more.
  • the number of the plug structures is at least one or more.
  • the top surface size of the plug structure is larger than the bottom surface size.
  • the present invention provides the following technical solutions:
  • a neural microelectrode includes the above composite microneedle structure.
  • the application of the above-mentioned composite microneedle structure in tissue implantation avoids the shortcomings of using a single hard needle or soft needle; it can well fix the hard needle and the soft needle and prevent them from moving while allowing the hard needle to Easier to pull out.
  • the invention provides a composite microneedle structure and a neural microelectrode.
  • the composite microneedle structure includes hard needles and soft needles.
  • the soft needles are equipped with a first connection part, and the hard needles are equipped with a second connection part.
  • the connecting part, the first connecting part and the second connecting part are matched and connected to realize the combination of the hard needle and the soft needle.
  • the first connecting part and the second connecting part form a detachable connection, and the soft needle is auxiliaryly implanted into the tissue through the hard needle. After the soft needle is implanted into the tissue, the first connecting part is connected to the second connecting part. Partly separated.
  • the soft needle is brought into the tissue through the hard needle, and then the hard needle is pulled out, thus avoiding the disadvantages of using a single hard needle or soft needle.
  • the hard needle and the soft needle can be well fixed to prevent movement between them. More importantly, the hard needle can be easily Unplug.
  • Figure 1 is a schematic structural diagram of the composite microneedle of the present invention.
  • Figure 2 is a partially enlarged schematic diagram of the composite structure of the composite microneedle structure of the present invention.
  • Figure 3 is a schematic diagram 2 of the structure of the composite microneedle of the present invention.
  • Figure 4 is a partially enlarged schematic view of the composite structure of the composite microneedle structure of the present invention.
  • Figure 5 is a schematic diagram three of the structure of the composite microneedle of the present invention.
  • Figure 6 is a partially enlarged schematic diagram of the composite structure of the composite microneedle structure of the present invention.
  • Figure 7 is a schematic diagram of the plug structure of the composite microneedle structure of the present invention.
  • the embodiments of the present invention involve directional indications (such as up, down, left, right, front, back%), then the directional indications are only used to explain the position of a certain posture (as shown in the drawings). The relative positional relationship, movement conditions, etc. between the components under the display). If the specific posture changes, the directional indication will also change accordingly.
  • the present invention provides a microneedle structure composed of hard needles and soft needles.
  • a microneedle structure composed of hard needles and soft needles.
  • the hard needle and the soft needle can be well fixed.
  • the soft needle can be brought into the tissue through the hard needle, and then the hard needle can be pulled out, which can not only avoid the disadvantages of using a single hard needle or soft needle, but also can well fix the soft needle and the hard needle to prevent them from intertwining. movement occurs between them, and more importantly, it is convenient to pull out the hard needle.
  • a composite microneedle structure including a hard needle 2 and a soft needle 1.
  • a first connection part is arranged at the tail of the soft needle 1, and a second connection part grows on the hard needle 2.
  • the first connection part It is matched with the second connecting part to realize the combination of the hard needle 2 and the soft needle 1 .
  • the first connection part and the second connection part form a detachable connection.
  • the hard needle 2 and the soft needle 1 are realized by a plurality of semi-closed hole structures patterned at the tail of the soft needle 1 and a plurality of latch structures 3 arranged at corresponding positions of the hard needle 2 to cooperate with the hole structure. of compound.
  • the above-mentioned hole structures configured on the soft needle 1 include but are not limited to arc-shaped, rectangular or trapezoidal hole structures, as long as the graphical arrangement of the connection mode can be realized.
  • the plurality of latch structures 3 arranged at corresponding positions of the hard needle 2 to cooperate with the hole structure include but are not limited to cylindrical, rectangular columnar or trapezoidal structures, as long as a stable connection with the hole structure can be achieved.
  • the number of the hole structures and the number of the plug structures matching them can be set as needed, as long as a stable connection between the hole structure and the plug structure can be achieved, the number of the hole structures and the number of the plug structures matching them are both N , N is a positive integer ⁇ 1, for example, it can be 1, 2, 3, 4, 5, 6, 7, ....
  • the top surface size of the latch structure is larger than the bottom surface size. Connected with the bottom surface in a smooth transition, the opening of the hole structure is larger than the top surface size of the plug structure, and the opening of the hole structure is smaller than the top surface size of the plug structure.
  • the above-mentioned composite microneedle structure When the above-mentioned composite microneedle structure is used for tissue implantation, it can avoid the defects of using a single hard needle or soft needle; it can well fix the hard needle and the soft needle and prevent them from moving while making the hard needle more convenient. pulled out.
  • a composite microneedle structure has four semi-closed arc-shaped structures patterned at the tail of the soft needle 1, and is configured at the corresponding position of the hard needle 2 to match the arc-shaped structure.
  • the cylindrical latch structure 3 configured with the hard needle 2 passes through the arc-shaped structure at the tail of the soft needle 1, playing the role of fixing the hard needle 2 and the soft needle 1, and ensuring that the hard needle There will be no displacement between the hard needle 2 and the soft needle 1, thus realizing the combination of the hard needle 2 and the soft needle 1.
  • the hard needle 2 drives the soft needle 1 to be implanted into the tissue
  • the cylindrical pin structure 3 of the hard needle 2 is connected to the arc-shaped structure at the tail of the soft needle 1
  • the hard needle 2 can be pulled directly backward to easily insert the hard needle 2 into the tissue.
  • the hard needle 2 is pulled out, while the soft needle 1 remains in the body to achieve stable implantation of the microneedle.
  • a composite microneedle structure has four semi-closed rectangular structures patterned at the tail of the soft needle 1, and four rectangular columns matching the rectangular structure are arranged at the corresponding positions of the hard needle 2.
  • the rectangular cylindrical latch structure 3 configured with the hard needle 2 passes through the rectangular structure at the tail of the soft needle 1, plays the role of fixing the hard needle 2 and the soft needle 1, and can ensure that the hard needle 2 and the soft needle There will be no displacement between 1, and the combination of the hard needle 2 and the soft needle 1 is realized.
  • the hard needle 2 drives the soft needle 1 to be implanted into the tissue
  • the rectangular cylindrical pin structure 3 of the hard needle 2 is connected to the rectangular structure at the tail of the soft needle 1
  • the hard needle 2 can be pulled directly backward to easily remove the hard needle 2.
  • the needle 2 is pulled out, while the soft needle 1 remains in the body to achieve stable implantation of the microneedle.
  • a composite microneedle structure has four semi-closed trapezoidal structures patterned at the tail of the soft needle 1, and four ladder columns matching the trapezoidal structure are arranged at the corresponding positions of the hard needle 2.
  • the trapezoidal latch structure 3 configured by the hard needle 2 passes through the trapezoidal structure at the tail of the soft needle 1, playing the role of fixing the hard needle 2 and the soft needle 1, and can ensure that the hard needle 2 and the soft needle There will be no displacement between 1, and the combination of the hard needle 2 and the soft needle 1 is realized.
  • the hard needle 2 drives the soft needle 1 to be implanted into the tissue
  • the trapezoidal pin structure 3 of the hard needle 2 is connected to the trapezoidal structure at the tail of the soft needle 1
  • the hard needle 2 can be pulled directly backward to easily remove the hard needle 2.
  • the needle 2 is pulled out, while the soft needle 1 remains in the body to achieve stable implantation of the microneedle.
  • a microneedle with a readout circuit includes at least one microneedle body and a readout circuit.
  • the microneedle body is located on the readout circuit.
  • the readout circuit is formed on a silicon base.
  • the microneedle The components of the needle body and the readout circuit are respectively located on the front and back sides of the silicon base.
  • the first contact point of the microneedle body is electrically connected to the second contact point of the readout circuit to achieve rapid reading of neural data.
  • the electrically connected contacts do not interfere with the hole structure, such as avoidance design, or the above hole structure settings and circuit contact settings are all within the capabilities of those skilled in the art. Implementation.
  • this application patterns a semi-closed arc-shaped, rectangular or trapezoidal hole structure on the tail of the soft needle 1, and grows a cylindrical, rectangular column or trapezoidal hole structure on the corresponding surface of the hard needle 2.
  • Cylindrical and other latch structures 3, the latch structure 3 will pass through the hole structure, thereby playing the role of fixing the hard needle and the soft needle, and can ensure that the hard needle and the soft needle will not be displaced, solving the problem in the existing technology technical issues.
  • the soft needle can include multiple body electrodes, and body electrode points and connecting lines are provided on the body electrodes.
  • the spacing between adjacent body electrodes is 200 ⁇ m to 250 ⁇ m, and the preferred spacing is 230 ⁇ m; the line width of the connecting lines is 0.1 ⁇ m ⁇ 0.5 ⁇ m, the preferred spacing is 0.3 ⁇ m; the spacing between adjacent body electrode points is 20 ⁇ m ⁇ 40 ⁇ m, the preferred spacing is 30 ⁇ m; the width of the body electrode is 80 ⁇ m ⁇ 100 ⁇ m, and the length of the body electrode 1 is 3 ⁇ 5.5mm, the tip angle of body electrode 1 is 17 ⁇ 30°.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

一种复合微针结构及神经微电极，通过在软针（1）的尾部图形化半封闭式孔洞结构和在硬针（2）的相应位置生长插销结构（3）来固定硬针（2）与软针（1），避免了采用单一硬针（2）或软针（1）的缺陷；能够很好的固定硬针（2）和软针（1），防止它们之间发生移动的同时，使得硬针（2）能够更加方便地拔出。

Description

一种复合微针结构及神经微电极 技术领域
本发明涉及生物医学工程技术脑机接口领域，具体涉及一种复合微针结构及神经微电极。
背景技术
目前侵入式微针结构多数为单一类型电极，如硬针结构的密西根电极、犹他电极，软针结构的聚酰亚胺电极。
对于硬针(刚性针)在植入时无法随着血管伸缩而进行适应性形变，可能会对组织造成一定的损伤；而软针结构在植入时易发生变形，需借助外部设备辅助植入，但存在结构复杂，效率低下等问题，上述两种单一类型针体不能满足目前临床需求。
由此，目前需要有一种方案来解决现有技术中的问题。
发明内容
本发明提供一种复合微针结构及神经微电极，至少可以解决现有技术中存在的部分问题。
为解决上述技术问题，根据本发明的一个方面，本发明提供了如下技术方案：
一种复合微针结构，包括硬针与软针，在所述软针上配置有第一连接部，在所述硬针上配置有第二连接部，所述第一连接部和所述第二连接部配合连接，实现所述硬针与所述软针的复合。
作为本发明所述的一种复合微针结构的优选方案，其中：优选在所述软针的尾部配置所述第一连接部，以方便硬针与软针的复合。
作为本发明所述的一种复合微针结构的优选方案，其中：所述第一连接部优选为在软针的尾部图形化的孔洞结构。
作为本发明所述的一种复合微针结构的优选方案，其中：所述第二连接部优选为在硬针的相应位置配置的与孔洞结构配合的插销结构。
作为本发明所述的一种复合微针结构的优选方案，其中：在硬针的相应 位置配置的与孔洞结构配合的插销结构通过生长的方式实现。
作为本发明所述的一种复合微针结构的优选方案，其中：所述孔洞结构为半封闭式。
作为本发明所述的一种复合微针结构的优选方案，其中：所述孔洞结构为可以为圆弧形、矩形或梯形。
作为本发明所述的一种复合微针结构的优选方案，其中：所述插销结构可以为圆柱形、矩柱形或梯柱形。
作为本发明所述的一种复合微针结构的优选方案，其中：所述孔洞结构的数量为至少一个或多个。
作为本发明所述的一种复合微针结构的优选方案，其中：所述插销结构的数量为至少一个或多个。
作为本发明所述的一种复合微针结构的优选方案，其中：所述插销结构的顶面尺寸大于底面尺寸。
为解决上述技术问题，根据本发明的一个方面，本发明提供了如下技术方案：
一种神经微电极，包括上述的复合微针结构。
上述复合微针结构在进行组织植入时的应用，避免了采用单一硬针或软针的缺陷；能够很好的固定硬针和软针，防止它们之间发生移动的同时，使得硬针能够更加方便地拔出。
本发明的有益效果如下：
本发明提供了一种复合微针结构及神经微电极，该复合微针结构包括硬针与软针，在所述软针上配置有第一连接部，在所述硬针上配置有第二连接部，所述第一连接部和所述第二连接部配合连接，实现所述硬针与所述软针的复合。所述第一连接部和所述第二连接部形成可拆卸连接，通过硬针将软针辅助植入到组织中，在软针植入到组织中后，将第一连接部与第二连接部分离。
进一步地，通过硬针将软针带入组织内，再拔出硬针，避免了采用单一硬针或软针的缺陷。通过在软针的尾部图形化半封闭式孔洞结构和在硬针的相应位置配置插销结构，能够很好的固定硬针和软针，防止它们之间发生移动，更重要的是硬针能够方便拔出。
附图说明
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图示出的结构获得其他的附图。
图1为本发明复合微针结构示意图一；
图2为本发明复合微针结构的复合结构局部放大示意图一；
图3为本发明复合微针结构示意图二；
图4为本发明复合微针结构的复合结构局部放大示意图二；
图5为本发明复合微针结构示意图三；
图6为本发明复合微针结构的复合结构局部放大示意图三；
图7为本发明复合微针结构的插销结构示意图；
附图标号说明：
1-软针，2-硬针，3-插销结构。
本发明目的的实现、功能特点及优点将结合实施例，参照附图做进一步说明。
具体实施方式
下面将结合实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明的一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
需要说明，若本发明实施例中有涉及方向性指示(诸如上、下、左、右、前、后……)，则该方向性指示仅用于解释在某一特定姿态(如附图所示)下各部件之间的相对位置关系、运动情况等，如果该特定姿态发生改变时，则该方向性指示也相应地随之改变。
另外，若本发明实施例中有涉及“第一”、“第二”等的描述，则该“第一”、“第二”等的描述仅用于描述目的，而不能理解为指示或暗示其相对重要性或者隐含指明所指示的技术特征的数量。由此，限定有“第一”、“第二”的特征可以明示或者隐含地包括至少一个该特征。另外，各个实施例之 间的技术方案可以相互结合，但是必须是以本领域普通技术人员能够实现为基础，当技术方案的结合出现相互矛盾或无法实现时应当认为这种技术方案的结合不存在，也不在本发明要求的保护范围之内。
本发明提供了一种硬针与软针复合的微针结构，通过在软针的尾部图形化半封闭式孔洞结构和在硬针的相应位置配置插销结构，能够很好的固定硬针和软针，在使用时可以通过硬针将软针带入组织内，再拔出硬针，既可以避免采用单一硬针或软针的缺陷，又能够很好固定软针与硬针，防止它们之间发生移动，更重要的是方便硬针拔出。
本发明提供了如下技术方案：
一种复合微针结构，包括硬针2与软针1，在所述软针1尾部配置有第一连接部，在所述硬针2上生长有第二连接部，所述第一连接部和所述第二连接部配合连接，实现所述硬针2与所述软针1的复合。其中，所述第一连接部和所述第二连接部形成可拆卸连接。
通过在软针1的尾部图形化的半封闭式的多个孔洞结构和在硬针2的相应位置配置的与孔洞结构配合的多个插销结构3实现所述硬针2与所述软针1的复合。
在软针1上配置的上述孔洞结构包括但不限于圆弧形、矩形或梯形孔洞结构，只要能够实现连接方式的图形化设置均可。
在硬针2的相应位置配置的与孔洞结构配合的多个插销结构3包括但不限于圆柱形、矩柱形或梯柱形结构，只要能够实现与孔洞结构的稳定连接均可。
所述孔洞结构的数量和与其配合的插销结构的数量可以根据需要设置，只要能够实现孔洞结构与插销结构的稳定连接均可，所述孔洞结构的数量和与其配合的插销结构的数量均为N，N为≥1的正整数，例如可以为1、2、3、4、5、6、7、……。
为了便于插销结构插入到孔洞结构，同时保证插销结构插入到所述孔洞结构后具有较强的稳定性，在优选的实施例中，所述插销结构的顶面尺寸大于底面尺寸，所述顶面与所述底面圆滑过渡连接，所述孔洞结构的开口大于所述插销结构的顶面尺寸，所述孔洞结构的开口小于所述插销结构的顶面尺寸。
上述复合微针结构应用于组织植入时，可以避免采用单一硬针或软针的缺陷；能够很好的固定硬针和软针，防止它们之间发生移动的同时，使得硬针能够更加方便地拔出。
实施例1
如图1-2所示，一种复合微针结构，在软针1的尾部图形化出4个半封闭式的圆弧形结构，在硬针2的相应位置配置与圆弧形结构配合的4个圆柱形插销结构3，所述硬针2配置的圆柱形插销结构3穿过软针1尾部的圆弧形结构，起到固定硬针2和软针1的作用，并能够保证硬针2和软针1之间不会发生位移，实现所述硬针2与所述软针1的复合。当硬针2带动软针1一同植入组织后，在硬针2配置的圆柱形插销结构3和软针1尾部的圆弧形结构连接的情况下，直接向后拉动硬针2，轻松将硬针2拔出，同时保留软针1留在体内，实现微针的稳定植入。
实施例2
如图3-4所示，一种复合微针结构，在软针1的尾部图形化出4个半封闭式的矩形结构，在硬针2的相应位置配置与矩形结构配合的4个矩柱形插销结构3，所述硬针2配置的矩柱形插销结构3穿过软针1尾部的矩形结构，起到固定硬针2和软针1的作用，并能够保证硬针2和软针1之间不会发生位移，实现所述硬针2与所述软针1的复合。当硬针2带动软针1一同植入组织后，在硬针2配置的矩柱形插销结构3和软针1尾部的矩形结构连接的情况下，直接向后拉动硬针2，轻松将硬针2拔出，同时保留软针1留在体内，实现微针的稳定植入。
实施例3
如图5-6所示，一种复合微针结构，在软针1的尾部图形化出4个半封闭式的梯形结构，在硬针2的相应位置配置与梯形结构配合的4个梯柱形插销结构3，所述硬针2配置的梯柱形插销结构3穿过软针1尾部的梯形结构，起到固定硬针2和软针1的作用，并能够保证硬针2和软针1之间不会发生位移，实现所述硬针2与所述软针1的复合。当硬针2带动软针1一同植入组织后，在硬针2配置的梯柱形插销结构3和软针1尾部的梯形结构连接的情况下，直接向后拉动硬针2，轻松将硬针2拔出，同时保留软针1留在体内，实现微针的稳定植入。
关于微针配套使用的电路要求，带有读出电路的微针，包括至少一个微针体以及读出电路，微针体位于读出电路上，读出电路是形成在硅基上的，微针体和读出电路的元器件分别位于硅基的正反面，微针体的第一触点与读出电路的第二触点电连接，以实现神经数据的快速读取。在上述电路存在的情况下，仅需要考虑设置电连接的触点与孔洞结构不发生干涉即可，诸如规避设计，或者而上述的孔洞结构设置以及电路触点设置均是本领域技术人员能够充分实施的。
如图7所示，本申请通过在软针1的尾部图形化出半封闭式的圆弧形、矩形或梯形等孔洞结构，在硬针2相对应的表面生长圆柱形、矩柱形或梯柱形等插销结构3，插销结构3会穿过孔洞结构，从而起到固定硬针和软针的作用，并能够保证硬针和软针之间不会发生位移，解决了现有技术中存在的技术问题。
此外，软针可以包含多个体电极，体电极上设置有体电极点和连接线，相邻所述体电极之间的间距为200μm～250μm，优选的间距为230μm；连接线的线宽为0.1μm～0.5μm，优选的间距为0.3μm；相邻所述体电极点之间的间距为20μm～40μm，优选的间距为30μm；体电极的宽度为80μm～100μm，体电极1长度为3～5.5mm，体电极1的针尖角度为17～30°。在上述结构尺寸的情况下，仅需要考虑设置连接结构的配合尺寸公差即可，上述相对应的设置均是本领域技术人员能够充分实施的。其余附加结构的配合公差在本申请中暂不赘述。
以上所述仅为本发明的优选实施例，并非因此限制本发明的专利范围，凡是在本发明的发明构思下，利用本发明说明书内容所作的等效结构变换，或直接/间接运用在其他相关的技术领域均包括在本发明的专利保护范围内。

Claims (10)

  1. 一种复合微针结构，其特征在于：包括硬针与软针，在所述软针上配置有第一连接部，在所述硬针上配置有第二连接部，所述第一连接部和所述第二连接部配合连接，实现所述硬针与所述软针的复合。
  2. 根据权利要求1所述的一种复合微针结构，其特征在于：在所述软针的尾部配置所述第一连接部。
  3. 根据权利要求1或2所述的一种复合微针结构，其特征在于：所述第一连接部为孔洞结构。
  4. 根据权利要求3所述的一种复合微针结构，其特征在于：所述孔洞结构为半封闭式。
  5. 根据权利要求3所述的一种复合微针结构，其特征在于：所述孔洞结构包括圆弧形、矩形或梯形。
  6. 根据权利要求3所述的一种复合微针结构，其特征在于：所述第二连接部为插销结构。
  7. 根据权利要求6所述的一种复合微针结构，其特征在于：所述插销结构包括与孔洞结构配合的圆柱形、矩柱形或梯柱形。
  8. 根据权利要求6所述的一种复合微针结构，其特征在于：所述孔洞结构的数量和插销结构的数量相同，且数量为一个或多个。
  9. 根据权利要求6所述的一种复合微针结构，其特征在于：所述插销结构的顶面尺寸大于底面尺寸。
  10. 一种神经微电极，其特征在于，所述神经微电极包括如权利要求1-8中任一项所述的复合微针结构。
PCT/CN2022/126570 2022-07-25 2022-10-21 一种复合微针结构及神经微电极 WO2024021323A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202210880708.5A CN115227254B (zh) 2022-07-25 2022-07-25 一种复合微针结构及神经微电极
CN202210880708.5 2022-07-25

Publications (1)

Publication Number Publication Date
WO2024021323A1 true WO2024021323A1 (zh) 2024-02-01

Family

ID=83674889

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2022/126570 WO2024021323A1 (zh) 2022-07-25 2022-10-21 一种复合微针结构及神经微电极

Country Status (2)

Country Link
CN (1) CN115227254B (zh)
WO (1) WO2024021323A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115281682B (zh) * 2022-07-25 2024-06-14 武汉衷华脑机融合科技发展有限公司 一种复合微针结构及其制备方法
CN115500831B (zh) * 2022-08-24 2024-01-12 武汉衷华脑机融合科技发展有限公司 一种基于集成电路芯片的复合微针结构

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090187196A1 (en) * 2007-10-17 2009-07-23 Vetter Rio J Guide tube for an implantable device system
CN101884530A (zh) * 2010-07-14 2010-11-17 中国科学院半导体研究所 用于记录神经活动电信号的柔性探针电极及其植入工具
CN111990995A (zh) * 2020-09-10 2020-11-27 中国科学院半导体研究所 柔性电极植入系统
CN112386262A (zh) * 2020-11-18 2021-02-23 中国科学院半导体研究所 U型柔性电极植入系统及其制备方法
CN112999511A (zh) * 2021-03-10 2021-06-22 中国科学院半导体研究所 柔性电极导入装置
WO2022005386A1 (en) * 2020-07-03 2022-01-06 Neuronano Ab Microelectrode for insertion into soft tissue
CN114014252A (zh) * 2021-11-02 2022-02-08 杭州电子科技大学温州研究院有限公司 一种高密度低噪声刚柔结合神经探针及其制备方法
CN114376580A (zh) * 2022-01-04 2022-04-22 中国科学院上海微系统与信息技术研究所 一种柔性神经电极及其制备方法、脑机接口
CN114788700A (zh) * 2022-02-25 2022-07-26 武汉衷华脑机融合科技发展有限公司 一种带有辅助结构的神经接口
CN115054825A (zh) * 2022-06-17 2022-09-16 中国科学院脑科学与智能技术卓越创新中心 一种用于针灸的柔性电极及其制造方法
CN115153566A (zh) * 2022-06-16 2022-10-11 武汉衷华脑机融合科技发展有限公司 一种微电极结构及其制作方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1245076A (zh) * 1998-08-14 2000-02-23 黄高樟 安全静脉留置针
US8738110B2 (en) * 2009-05-01 2014-05-27 Livermore National Security, Llc Rigid spine reinforced polymer microelectrode array probe and method of fabrication
CN102499666B (zh) * 2011-10-17 2013-04-24 上海交通大学 神经刚柔结构微电极
SG193098A1 (en) * 2012-02-13 2013-09-30 Agency Science Tech & Res A probe device and a method of fabricating the same
CN104970804B (zh) * 2014-04-01 2018-05-04 微凸科技股份有限公司 连续经皮微针监测系统
CN107473175B (zh) * 2017-08-15 2019-09-06 薛宁 一种基于多孔硅和聚合物的神经电极及其制作工艺和应用
US20200261025A1 (en) * 2017-09-08 2020-08-20 Board Of Regents, The University Of Texas System System and method for making and implanting high-density electrode arrays
CN215023978U (zh) * 2021-03-26 2021-12-07 普昂(杭州)健康管理有限公司 一种穿刺组件及分体式敷贴皮下软针
CN113855031A (zh) * 2021-09-18 2021-12-31 浙江清华柔性电子技术研究院 柔性微针电极及其制备方法

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090187196A1 (en) * 2007-10-17 2009-07-23 Vetter Rio J Guide tube for an implantable device system
CN101884530A (zh) * 2010-07-14 2010-11-17 中国科学院半导体研究所 用于记录神经活动电信号的柔性探针电极及其植入工具
WO2022005386A1 (en) * 2020-07-03 2022-01-06 Neuronano Ab Microelectrode for insertion into soft tissue
CN111990995A (zh) * 2020-09-10 2020-11-27 中国科学院半导体研究所 柔性电极植入系统
CN112386262A (zh) * 2020-11-18 2021-02-23 中国科学院半导体研究所 U型柔性电极植入系统及其制备方法
CN112999511A (zh) * 2021-03-10 2021-06-22 中国科学院半导体研究所 柔性电极导入装置
CN114014252A (zh) * 2021-11-02 2022-02-08 杭州电子科技大学温州研究院有限公司 一种高密度低噪声刚柔结合神经探针及其制备方法
CN114376580A (zh) * 2022-01-04 2022-04-22 中国科学院上海微系统与信息技术研究所 一种柔性神经电极及其制备方法、脑机接口
CN114788700A (zh) * 2022-02-25 2022-07-26 武汉衷华脑机融合科技发展有限公司 一种带有辅助结构的神经接口
CN115153566A (zh) * 2022-06-16 2022-10-11 武汉衷华脑机融合科技发展有限公司 一种微电极结构及其制作方法
CN115054825A (zh) * 2022-06-17 2022-09-16 中国科学院脑科学与智能技术卓越创新中心 一种用于针灸的柔性电极及其制造方法

Also Published As

Publication number Publication date
CN115227254B (zh) 2024-06-25
CN115227254A (zh) 2022-10-25

Similar Documents

Publication Publication Date Title
WO2024021323A1 (zh) 一种复合微针结构及神经微电极
WO2024021325A1 (zh) 一种复合微针结构及其制备方法
JP2018152338A (ja) Ｐｃｂサブコネクタ
US8242374B2 (en) Flexible-circuit-board cable with positioning structure for insertion
JP5373809B2 (ja) メスコネクタ、それに組付けるオスコネクタ、それらを用いた電気・電子機器
US20120195024A1 (en) Flexible circuit board connection structure and display device
TWI555283B (zh) Connector
TWM408835U (en) Connector and connector assembly
TWM472327U (zh) 連接器
JP6909304B2 (ja) 医療機器用の大容量コネクタ
US20140308850A1 (en) Connector with piercing tail
WO2024040731A1 (zh) 一种基于集成电路芯片的复合微针结构
KR100473991B1 (ko) 접촉자 및 이것을 이용한 전기적 접속장치
CN115500833A (zh) 一种定位隔板和面阵式微针结构
WO2024021324A1 (zh) 一种复合微针结构及其制备方法
JP2001148547A (ja) 電気装置の接続に用いるｃｏｆ基板
JPH10255925A (ja) 接続装置
CN219144521U (zh) 导电簧片及电连接结构
CN219760153U (zh) 一种高频传输连接器
CN216167344U (zh) 一种儿童口腔检查辅助装置
CN215771793U (zh) 一种电路板固定连接装置及电子设备
CN214542639U (zh) 电路板连接器以及电路板结构
CN210641134U (zh) 一种挠性集成电路板
CN211907865U (zh) 线圈连接器、连接器组件、线圈单元及核磁共振成像系统
JP3223930U (ja) アダプター

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 22952762

Country of ref document: EP

Kind code of ref document: A1