WO2023218733A1 - Dispositif de mesure de conductivité électrique et son procédé de fabrication - Google Patents

Dispositif de mesure de conductivité électrique et son procédé de fabrication Download PDF

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Publication number
WO2023218733A1
WO2023218733A1 PCT/JP2023/007078 JP2023007078W WO2023218733A1 WO 2023218733 A1 WO2023218733 A1 WO 2023218733A1 JP 2023007078 W JP2023007078 W JP 2023007078W WO 2023218733 A1 WO2023218733 A1 WO 2023218733A1
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Prior art keywords
liquid
flow path
electrical conductivity
sheet
measuring device
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PCT/JP2023/007078
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English (en)
Japanese (ja)
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憲児 坂本
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国立大学法人 九州工業大学
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Publication of WO2023218733A1 publication Critical patent/WO2023218733A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
    • G01N27/06—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R27/00—Arrangements for measuring resistance, reactance, impedance, or electric characteristics derived therefrom
    • G01R27/02—Measuring real or complex resistance, reactance, impedance, or other two-pole characteristics derived therefrom, e.g. time constant
    • G01R27/22—Measuring resistance of fluids

Definitions

  • the present invention relates to an electrical conductivity measuring device for measuring the electrical conductivity level of a liquid and a method for manufacturing the same.
  • the amount of each component of saliva changes depending on stress. Since the content of each component in saliva affects the viscosity of saliva, stress can be evaluated by measuring the viscosity of saliva. Therefore, measuring the viscosity of body fluids is effective in confirming a person's health condition.
  • the viscosity of a body fluid can be measured using, for example, the body fluid viscosity measuring device described in Patent Document 1.
  • the device has a chip in which a channel for flowing body fluid is formed, and is designed so that the chip can be replaced every time the viscosity of the body fluid is measured.
  • the device also uses physical quantities (hereinafter referred to as " Evaluate the viscosity of body fluids from the electrical conductivity value (also called “electrical conductivity value").
  • the present invention has been made in view of the above circumstances, and provides an electrical conductivity measuring device and a method for manufacturing the same, which can measure the electrical conductivity value of a liquid at low cost without using a chip with finely processed resin bodies. The purpose is to provide.
  • An electrical conductivity measuring device that measures a conductivity value representing the electrical conductivity level of a liquid, and includes a flow path made of a material capable of absorbing the liquid; first and second electrodes that are spaced apart from each other in contact with the flow path; an application unit that applies voltage to the first electrode; an arithmetic unit that detects an electrical resistance value between the first and second electrodes that are electrically connected to each other, and derives the electrical conductivity value of the liquid.
  • a method of manufacturing an electrical conductivity measuring device that meets the above object is a method of manufacturing an electrical conductivity measuring device that measures a conductivity value representing the electrical conductivity level of a liquid, which includes a mold in which a through hole is formed. a step of applying a lyophobic agent to one side of the sheet; and pressing one side of the mold against one side of the sheet capable of absorbing the liquid to absorb the liquid in a region of the sheet corresponding to the through hole. forming a flow path, and providing a lyophobic portion around the flow path of the sheet to prevent the liquid absorbed in the flow path from flowing out of the flow path.
  • a method of manufacturing an electrical conductivity measuring device in accordance with the above object is a method of manufacturing an electrical conductivity measuring device that measures a conductivity value representing the electrical conductivity level of a liquid, wherein a groove is formed on one side. a step of applying a lyophobic agent to the one side of the mold, and pressing the one side of the mold against one side of the sheet capable of absorbing the liquid to apply the liquid to the area corresponding to the groove of the sheet. forming a flow path for absorption, and providing a lyophobic portion around the flow path of the sheet to prevent the liquid absorbed in the flow path from flowing out of the flow path.
  • An electrical conductivity measuring device includes: a flow path made of a material capable of absorbing liquid; first and second electrodes that are spaced apart from each other in contact with the flow path; Detects the electrical resistance value between an application unit that applies a voltage to the electrode, and the first and second electrodes that are electrically connected via the liquid absorbed in the flow path, and derives the conductivity value of the liquid. Since the flow path can be formed from paper, for example, the electrical conductivity value of the liquid can be measured at low cost without using a chip made of finely processed resin material.
  • the method for manufacturing an electrical conductivity measuring device includes the steps of applying a lyophobic agent to one side of a mold in which a through hole is formed, and applying a lyophobic agent to one side of a sheet capable of absorbing liquid. One side is pressed to form a channel for absorbing liquid in the area corresponding to the through hole of the sheet, and the liquid absorbed in the channel is prevented from flowing out of the channel around the channel of the sheet. and a step of providing a lyophobic portion.
  • the method for manufacturing an electrical conductivity measuring device includes the steps of applying a lyophobic agent to one side of a mold having grooves formed on one side, and applying a lyophobic agent to one side of a sheet capable of absorbing liquid. , one side of the mold is pressed to form a channel for absorbing liquid in the area corresponding to the groove of the sheet, and a channel is formed around the channel of the sheet to prevent the liquid absorbed in the channel from flowing out of the channel.
  • the present invention includes the step of providing a lyophobic portion that prevents this, it is possible to manufacture an electrical conductivity measurement device that can measure the electrical conductivity value of a liquid at a low cost without using a chip in which a resin body is minutely processed.
  • FIG. 1 is an explanatory diagram of an electrical conductivity measuring device according to an embodiment of the present invention.
  • (A) and (B) are partial cross-sectional views of the electrical conductivity measuring device, respectively.
  • (A) and (B) are explanatory diagrams each showing how the liquid L moves through the flow path.
  • (A) and (B) are electron microscope images taken of the first electrode formed on the sheet.
  • (A) and (B) are explanatory diagrams each showing a process for forming a flow path in a sheet. It is an explanatory view showing a process of forming a channel in a sheet using another mold.
  • FIG. 2 is an explanatory diagram showing the results of a first experiment.
  • FIG. 3 is an explanatory diagram showing the results of a second experiment.
  • FIG. 7 is an explanatory diagram showing the results of a third experiment.
  • an electrical conductivity measuring device 10 measures the electrical conductivity level of the liquid L.
  • a device for measuring electrical conductivity values which includes a channel 11 made of a material capable of absorbing liquid L, first electrodes 12, 13, 14, 15, and second electrodes provided alternately at intervals. 16, 17, 18, and 19, an application section 20 that applies a voltage to the first electrodes 12, 13, 14, and 15, and a calculation section 21 that derives the electric value of the liquid L. This will be explained in detail below.
  • the liquid L is not particularly limited, and may be, for example, a body fluid such as blood or saliva, or an electrolyte.
  • a body fluid such as blood or saliva
  • an electrolyte an example of a liquid containing water
  • the conductivity value indicating the electrical conductivity level of the liquid L is a value indicating the ease or difficulty of conducting electricity of the liquid L. Examples of the conductivity value include electrical conductivity, electrical resistivity, and electrical conductivity. and values that are correlated with electrical resistivity.
  • the first electrodes 12, 13, 14, 15 and the second electrodes 16, 17, 18, 19 are made of a material capable of absorbing the liquid L, as shown in FIGS. It is provided on one side (front side) of the formed sheet 22.
  • the sheet 22 is made of paper or nonwoven fabric made of fibers that are lyophilic to the liquid L (having a high affinity for the liquid L), and is deformed by pressing.
  • the rectangular sheet 22 has a linear channel 11 and a liquid supply section 23 connected to one end of the channel 11 and circular in plan view. Therefore, the channel 11 is made of paper or nonwoven fabric made of lyophilic fibers. Further, the liquid supply section 23 is also capable of absorbing the liquid L.
  • the liquid L is supplied to the liquid supply part 23, the liquid L is absorbed into the liquid supply part 23, as shown in FIG. 3(A), and a part or most of it is absorbed as shown in FIG. 3(B). Then, the liquid L is absorbed into the flow path 11 (moves to the flow path 11), and a part or most of the liquid L absorbed into the flow path 11 moves along the flow path 11 toward the other end of the flow path 11.
  • the sheet 22 has a flow path 11, and around the flow path 11 of the sheet 22, the liquid L absorbed in the liquid supply portion 23 and the flow path 11 flows outside the liquid supply portion 23 or A lyophobic portion 25 is formed to prevent the liquid from flowing out of the flow path 11.
  • the lyophobic portion 25 is formed by impregnating a predetermined region of the sheet 22 with a hydrophobic liquid (or an oleophobic liquid if the liquid L contains oil).
  • a hydrophobic liquid for example, a fluorine coating agent, an oil-based paint, or a wax can be employed.
  • fluorine coating agents examples include Fluorosurf (registered trademark) manufactured by Fluoro Technology Co., Ltd.
  • oil-based paints include oil-based Top Guard (“Top Guard” is a registered trademark) manufactured by Campehapio Co., Ltd.
  • the first electrodes 12, 13, 14, 15 and the second electrodes 16, 17, 18, 19 are connected to the channel portion 11 on one side of the sheet 22, respectively, as shown in FIGS. 1 and 2(B). These are line-shaped metal plates (copper plates in this embodiment) that are orthogonally crossed (crossed) and are spaced apart and parallel to each other with some of them in contact with the flow path 11. Towards the end, the second electrode 16, the first electrode 12, the second electrode 17, the first electrode 13, the second electrode 18, the first electrode 14, the second electrode 19 and the first The electrodes 15 are sequentially arranged at equal pitches.
  • the flow path 11 has a region (hereinafter referred to as " An electrode non-contact area (also referred to as an “electrode non-contact area”) protrudes and is exposed on one side of the sheet 22.
  • the area of the flow path 11 that the first electrode 12 contacts (hereinafter also referred to as “electrode contact area”) is covered with the first electrode 12 on one side, as shown in FIG. 2(B). ing.
  • This also applies to each region of the flow path 11 where the first electrodes 13, 14, 15 and the second electrodes 16, 17, 18, 19 are in contact. That is, the metal forming the first electrodes 12 , 13 , 14 , 15 and the second electrodes 16 , 17 , 18 , 19 includes some fibers of the flow path 11 .
  • Both the electrode non-contact area and the electrode contact area of the channel 11 are covered with a lyophobic portion 25 from the other surface side (back side) to both side surfaces, as shown in FIGS. 2(A) and 2(B). . Therefore, the liquid L absorbed in the channel 11 moves along the channel 11 while being prevented from flowing out of the channel 11, as shown in FIGS. 3(A) and 3(B). .
  • the entire circumference of the cross section of the flow path 11 is covered with the lyophobic portion 25.
  • only both side surfaces of the flow path 11 may be covered by the lyophobic portion 25 (that is, the other side of the flow path 11 does not need to be covered by the lyophobic portion 25).
  • most of the first electrode 12 is formed in a state that is soaked into the sheet 22, as shown in FIGS. 4(A) and 4(B), and includes some fibers of the sheet 22. are doing.
  • This also applies to the first electrodes 13, 14, 15 and the second electrodes 16, 17, 18, 19. That is, the first electrodes 12, 13, 14, 15 and the second electrodes 16, 17, 18, 19 are each made of metal that includes some fibers of the sheet 22.
  • cracks are formed in the first electrodes 12, 13, 14, 15 and the second electrodes 16, 17, 18, 19, respectively, into which the liquid L moving through the flow path 11 flows. There is. By forming such cracks in the first electrodes 12, 13, 14, 15 and the second electrodes 16, 17, 18, 19, the relationship between the liquid L and the first electrodes is greater than in the case where no cracks are formed. The contact area between the electrodes 12, 13, 14, 15 and the second electrodes 16, 17, 18, 19 is increased.
  • the first electrodes 12, 13, 14, 15 are connected to the application unit 20 via a conducting wire 26, and the second electrodes 16, 17, 18, 19 are connected to a conducting wire 27 and an AD (not shown). It is connected to the calculation unit 21 via a converter.
  • the application unit 20 is designed to be able to apply an alternating current voltage of a predetermined magnitude to the first electrodes 12 , 13 , 14 , 15 via a conducting wire 26 . Note that an application unit that applies a DC voltage may be employed.
  • the calculation unit 21 can be configured to include, for example, a CPU, a memory, and an interface into which electrical signals are input, and the calculation unit 21 can be configured to include, for example, a CPU, a memory, and an interface into which electrical signals are input. It is designed so that the conductivity value of the liquid L can be derived based on the voltage signal (in this embodiment, the voltage signal).
  • the electrical conductivity measuring device 10 measures the electrical conductivity value of the liquid L through the following steps S1 to S7.
  • Step S1 The application unit 20 applies a voltage of a predetermined magnitude to the first electrodes 12, 13, 14, and 15.
  • Step S2 A predetermined amount of liquid L is dropped into the liquid supply section 23, and the liquid L is absorbed into the liquid supply section 23.
  • the liquid L absorbed by the liquid supply part 23 moves to one end of the flow path 11, as shown in FIGS. Moving.
  • Step S3 The liquid L (the leading part of the liquid L) moving through the flow path 11 reaches the first electrode 12 via the second electrode 16, as shown in FIG. 3(B). Thereby, the second electrode 16 and the first electrode 12 are electrically connected via the liquid L absorbed in the region between the second electrode 16 and the first electrode 12 of the flow path 11, An electrical signal is output from the second electrode 16.
  • Step S4 The calculation unit 21 acquires the electric signal from the second electrode 16 via the AD converter, and calculates the electric resistance value between the second electrode 16 and the first electrode 12 (
  • the electrical resistance value also referred to as “one section electrical resistance value”
  • the electrical resistivity which is an example of the conductivity value of the liquid L, is derived based on the electrical resistance value.
  • the calculation unit 21 calculates the detected R1 ⁇ 1 is calculated by substituting ⁇ 1 into Equation 1 below. Note that the constants S and D are stored in the calculation unit 21 in advance.
  • Step S5 The liquid L moving through the channel 11 passes through the first electrode 12 and reaches the second electrode 17, and the second electrode 16, the first electrode 12, and the second electrode 17 are electrically connected via the liquid L absorbed in the region between the second electrodes 16 and 17 of the flow path 11, the calculation unit 21 outputs the output from the second electrodes 16 and 17.
  • An electrical signal is acquired via an AD converter. At this time, the second electrodes 16 and 17 are connected in parallel.
  • the arithmetic unit 21 detects that the liquid L has reached the second electrode 17 when the magnitude of the acquired electric signal exceeds a predetermined value, and the distance between the second electrodes 16 and 17 is increased.
  • the electrical resistance value (hereinafter also referred to as "two-section electrical resistance value”) is detected, and the conductivity value of the liquid L is derived.
  • the distance between the second electrodes 16 and 17 is twice the distance between the second electrode 16 and the first electrode 12, so it becomes 2D.
  • the theoretical value of the electrical resistance value in two sections is half the electrical resistance value in one section. Assuming that the electrical resistance value in the two sections is R2 and the electrical resistivity is ⁇ 2, the calculation unit 21 calculates ⁇ 2 by substituting the detected R2 into Equation 2 below.
  • Step S6 After that, the calculation unit 21 calculates the electrical resistivity of the liquid L each time the liquid L moving through the channel 11 reaches the first electrode 13, the second electrode 18, etc.
  • the number of electrical resistivities determined by the calculation unit 21 is assumed to be N.
  • Step S7 The calculation unit 21 determines the average value of the N (plural) electrical resistivities determined as the final electrical resistivity of the liquid L. Then, the calculation unit 21 determines the viscosity of the liquid L based on the final electrical resistivity of the liquid L using Walden's law.
  • the electrical conductivity measuring device 10 is manufactured through the following steps (the method for manufacturing the electrical conductivity measuring device 10 has the following steps).
  • Step S11 Perform silk screen printing on one side of the sheet 22 to apply conductivity to the locations where the first electrodes 12, 13, 14, 15, second electrodes 16, 17, 18, 19 and conductive wires 26, 27 are to be formed. Apply a paste (for example, silver paste).
  • a paste for example, silver paste
  • Step S12 By plating the sheet 22, a copper layer is provided on the part on one side of the sheet 22 where the conductive paste is applied, and the area where the flow path 11 is planned to be formed on the one side of the sheet 22 (the area where the flow path is planned to be formed) is formed.
  • First electrodes 12, 13, 14, 15 and second electrodes 16, 17, 18, 19 are provided at intervals, and conductive wires 26, 27 are formed on one side of the sheet 22.
  • Step S13 As shown in FIG. 5A, a lyophobic agent Q is applied to one side of a plate-shaped mold 30 in which through-holes 29 corresponding to the channel 11 and the liquid supply section 23 are formed.
  • Step S14 The mold 30 is arranged horizontally so that the one side coated with the lyophobic agent Q is positioned on the lower side, and the horizontally arranged sheet 22 with the one side applied on the upper side is placed below the mold 30.
  • Two sheet-shaped cushioning materials 31 and 32 are provided directly below the sheet 22, and with a sheet-shaped protective material 33 placed directly above the mold 30, the protective material 33, the mold 30, the sheet 22, and the buffer The materials 31 and 32 are stacked and placed between an upper mold 34 and a lower mold 35 of a press machine.
  • Step S15 Push down the upper mold 34 and apply pressure to the protective material 33, the mold 30, the sheet 22, and the cushioning materials 31 and 32 with the upper mold 34 and the lower mold 35, as shown in FIG. 5(B).
  • one side of the mold 30 is pressed against one side (upper side) of the sheet 22, and the lyophobic agent Q is impregnated into the sheet 22.
  • the lyophobic agent Q has not reached the other side of the sheet 22 at this point.
  • Step S16 The sheet 22 impregnated with the lyophobic agent Q from one side is taken out from the press, and the lyophobic agent Q is applied to the other side of the sheet 22 with a brush or the like.
  • Step S17 The sheet 22 is heated at 130° C. to harden the lyophobic agent Q.
  • the channel 11 and the liquid supply section 23 are formed in the region of the sheet 22 corresponding to the through hole 29 of the mold 30, and the lyophobic section 25 is provided around the channel 11 of the sheet 22.
  • a layer in which the lyophobic agent Q is cured is formed on the upper surface side of the first electrodes 12, 13, 14, 15 and the second electrodes 16, 17, 18, 19, but as shown in FIG. In this example, the description of the layer in which the lyophobic agent Q is cured is omitted.
  • the method for manufacturing the electrical conductivity measuring device 10 is to press one side of the mold 30 coated with the lyophobic agent Q onto one surface of the sheet 22, and to The flow path 11 is formed in the sheet 22, and a lyophobic portion 25 is provided around the flow path 11 in the sheet 22.
  • the target is a flow path where the amount of liquid L used for measuring the conductivity value is 20 ⁇ L
  • the surface of the area where the flow path is planned to be formed is masked with tape, and the lyophobic agent is applied to the area where the flow path is planned to be formed. It has been confirmed that it is possible to measure the conductivity value of the liquid L even if it is applied to the sheet from the surface side to form a flow path.
  • the method for manufacturing the electrical conductivity measuring device 10 includes a step of applying a lyophobic agent Q to an area other than the groove 37 on one side of the mold 38, and applying a lyophobic agent Q to one side of the sheet 22.
  • Step S18 Connect the applying section 20 and the calculating section 21 to the conducting wires 26 and 27, respectively. Thereby, the electrical conductivity measuring device 10 is completed.
  • the method for manufacturing the electrical conductivity measuring device 10 described above includes forming the first electrodes 12, 13, 14, 15 and the second electrodes 16, 17, 18, 19 on the sheet 22, and then forming the flow channels 11 on the sheet 22.
  • the first electrodes 12, 13, 14, 15 and the second electrodes 16, 17, 18, 19 may be formed on the sheet 22 provided with the flow path 11.
  • the first electrodes 12, 13, 14, 15 and the second electrodes 16, 17, 18, 19 which are in contact with the region of the sheet 22 where the flow path 11 is formed, are spaced apart. It will be provided with a blank space.
  • a filter paper having a filtration time of 300 seconds or less, a water absorption of 5 cm or more, and a thickness of 0.3 mm or less is used as the sheet 22 .
  • the water filtration time is based on JISP3801, and the water absorption rate means the height to which water rises in 10 minutes when a part of the sheet 22 in an upright state is immersed in water at 20°C.
  • the filtration time of the sheet 22 exceeds 300 seconds, the ability of the flow path 11 to move the liquid L (the liquid L contains water) is low, and it takes time to measure the conductivity value.
  • the lyophobic portion 25 cannot be stably formed by the method of manufacturing the electrical conductivity measuring device 10 described above. occurs. This is because the lyophobic agent Q (the lyophobic agent Q is a hydrophobic agent) is difficult to penetrate into the sheet 22, and the lyophobic portion 25 cannot be stably formed.
  • Sample P2 was different from sample P1 in that it had five first and second electrodes, and the distance between adjacent first and second electrodes was 2.5 mm.
  • Sample P3 differs from sample P2 in that the filter paper has hydrophobicity and that the filter paper was formed by hydrophilic treatment of the filter paper.
  • four types of experimental solutions were prepared by adding sucrose to physiological saline. Each experimental solution had a different concentration of sucrose and a different viscosity. Note that in samples P2 and P3 (same as sample P1), most of the first and second electrodes were formed within the filter paper, and included fibers constituting the filter paper.
  • the experimental solution was dropped into one end of the flow path of samples P2 and P3, and the electrical resistance value between the conductive parts connected to the five first electrodes and the conductive parts connected to the five second electrodes was measured. was measured, and the electrical resistivity was calculated from the measured electrical resistance value. Thereafter, the calculated electrical resistivity was compared with the viscosity coefficient measured in advance for each experimental solution. The comparison results are shown in FIG. From the comparison results, it was confirmed that there is a correlation between the electrical resistivity and the viscosity of the experimental solution for both samples P2 and P3, and that sample P2 has a higher detection resolution for the viscosity of the experimental solution than sample P3. Ta.
  • ⁇ Third experiment> In the third experiment, a linear and elongated sample P4 with a width of 1 mm was used, which was obtained by cutting out the filter paper of sample P2. A pin-shaped electrode is brought into contact with each of two locations spaced apart in the longitudinal direction of sample P4, and the experimental solution used in the second experiment is dropped onto one end of sample P4. The electrical resistance value between the first and second electrodes (corresponding to the first and second electrodes) was measured, and the electrical resistivity was calculated from the measured electrical resistance value. This calculation of electrical resistivity was performed for four types of experimental solutions having different viscosity coefficients in each case in which the state of contact of the pin-shaped electrode with sample P4 was changed.
  • sample P2 represents the experimental results for sample P2 in the second experiment
  • sample P4 point contact
  • sample P4 represents the experimental results when the tip of the pin-shaped electrode was brought into contact with sample P4.
  • sample P4 line contact
  • sample P4 is an experiment in which the side of a pin-shaped electrode was brought into linear contact with sample P4 (at this time, each pin-shaped electrode was arranged perpendicular to sample P4). represents the result.
  • the vertical axis represents the measured electrical resistance value as a relative value
  • the horizontal axis represents the viscosity of the experimental solution as a relative value.
  • sample P4 point contact
  • sample P4 line contact
  • the present invention is not limited to the above-described embodiments, and any changes in conditions that do not depart from the gist are within the scope of the present invention.
  • the first electrode may be provided on both one side and the other side of the sheet, and the first electrodes provided on the one side and the other side, respectively, may be electrically connected.
  • a flow path may be formed by performing lyophilic treatment on a sheet that does not absorb the target liquid. It is not always necessary to form a flow path in the sheet; for example, a hydrophilic string-like object may be fixed to a hydrophobic substrate and the string-like object may be used as the flow path.
  • the flow path does not need to be made of paper or nonwoven fabric, and may be made of, for example, molded wood chips or urethane.
  • the first and second electrodes do not need to have cracks into which the liquid moving through the flow path flows.
  • the measurement resolution of the conductivity value is lower than when the crack is formed.
  • the first and second electrodes can also be formed by a vapor phase method such as plasma CVD or vapor deposition.
  • the measurement resolution of the conductivity value is lower than when forming the first and second electrodes by plating (liquid phase method).
  • microprocessed resin is used to measure the electrical conductivity value of a liquid and to measure the viscosity of a liquid based on the electrical conductivity value of the liquid. It can be done without doing anything. Therefore, for example, it is possible to commercialize a measurement kit that is priced on the premise that people measure the viscosity of body fluids every day in ordinary households.

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Abstract

L'invention concerne un dispositif de mesure de conductivité électrique (10) destiné à mesurer la valeur de conductivité électrique représentant le taux de conductivité électrique d'un liquide : un passage d'écoulement (11) constitué d'un matériau absorbant les liquides ; des premières électrodes (12-15) et des secondes électrodes (16-19) qui sont disposées de manière à être espacées les unes des autres dans un état de contact avec le passage d'écoulement (11) ; une unité d'application (20) pour appliquer une tension aux premières électrodes (12-15) ; et une unité de calcul (21) pour détecter les valeurs de résistance électrique entre les premières électrodes (12-15) et les secondes électrodes (16-19) qui sont électriquement connectées par le biais du liquide absorbé par le passage d'écoulement (11), et pour en déduire la valeur d'électro-conductivité du liquide.
PCT/JP2023/007078 2022-05-12 2023-02-27 Dispositif de mesure de conductivité électrique et son procédé de fabrication WO2023218733A1 (fr)

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JP2022078911A JP7527027B2 (ja) 2022-05-12 2022-05-12 電気伝導性測定装置

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Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013181656A1 (fr) * 2012-06-01 2013-12-05 President And Fellows Of Harvard College Dispositifs microfluidiques formés à partir de papier hydrophobe
JP2013545109A (ja) * 2010-12-09 2013-12-19 ケヴァル，アルテュール 流体サンプル分析用のマイクロ流体デバイス
JP2015083963A (ja) * 2013-09-19 2015-04-30 株式会社リコー 流体デバイス、転写材、および流体デバイスの製造方法
WO2015152287A1 (fr) * 2014-03-31 2015-10-08 国立大学法人愛媛大学 Matériau fonctionnel, procédé de production d'un matériau fonctionnel, et liquide fonctionnel
JP2017133918A (ja) * 2016-01-27 2017-08-03 国立大学法人九州工業大学 体液粘性測定装置
JP3212682U (ja) * 2017-06-22 2017-09-28 味の素株式会社 体液受入れ構造体およびそれを有する体液分析装置
EP3225309A1 (fr) * 2016-03-31 2017-10-04 Biomérieux Membranes d'analyse de dispositifs microfluidiques et procédé de fabrication
WO2021220716A1 (fr) * 2020-04-28 2021-11-04 デクセリアルズ株式会社 Puce de test et son procédé de fabrication

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002328110A (ja) 2001-04-27 2002-11-15 Yamatake Corp 静電容量センサ
EP3225310A1 (fr) 2016-03-31 2017-10-04 Biomérieux Membranes d'analyse de dispositifs microfluidiques, réalisées en un matériau en fibre de verre
KR102117950B1 (ko) 2018-11-08 2020-06-02 계명대학교 산학협력단 바이오센서용 전극 제조방법 및 그 바이오센서용 전극
JP2023025871A (ja) 2021-08-11 2023-02-24 株式会社アドバンテスト 生乳測定器およびその製造方法
JP2023025870A (ja) 2021-08-11 2023-02-24 株式会社アドバンテスト 生乳測定器

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013545109A (ja) * 2010-12-09 2013-12-19 ケヴァル，アルテュール 流体サンプル分析用のマイクロ流体デバイス
WO2013181656A1 (fr) * 2012-06-01 2013-12-05 President And Fellows Of Harvard College Dispositifs microfluidiques formés à partir de papier hydrophobe
JP2015083963A (ja) * 2013-09-19 2015-04-30 株式会社リコー 流体デバイス、転写材、および流体デバイスの製造方法
WO2015152287A1 (fr) * 2014-03-31 2015-10-08 国立大学法人愛媛大学 Matériau fonctionnel, procédé de production d'un matériau fonctionnel, et liquide fonctionnel
JP2017133918A (ja) * 2016-01-27 2017-08-03 国立大学法人九州工業大学 体液粘性測定装置
EP3225309A1 (fr) * 2016-03-31 2017-10-04 Biomérieux Membranes d'analyse de dispositifs microfluidiques et procédé de fabrication
JP3212682U (ja) * 2017-06-22 2017-09-28 味の素株式会社 体液受入れ構造体およびそれを有する体液分析装置
WO2021220716A1 (fr) * 2020-04-28 2021-11-04 デクセリアルズ株式会社 Puce de test et son procédé de fabrication

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NOVIANA EKA, OZER TUGBA, CARRELL CODY S., LINK JEREMY S., MCMAHON CATHERINE, JANG ILHOON, HENRY CHARLES S.: "Microfluidic Paper-Based Analytical Devices: From Design to Applications", CHEMICAL REVIEWS, AMERICAN CHEMICAL SOCIETY, US, vol. 121, no. 19, 13 October 2021 (2021-10-13), US , pages 11835 - 11885, XP055854824, ISSN: 0009-2665, DOI: 10.1021/acs.chemrev.0c01335 *
THUO MARTIN M., MARTINEZ RAMSES V., LAN WEN-JIE, LIU XINYU, BARBER JABULANI, ATKINSON MANZA B. J., BANDARAGE DINETH, BLOCH JEAN-FR: "Fabrication of Low-Cost Paper-Based Microfluidic Devices by Embossing or Cut-and-Stack Methods", CHEMISTRY OF MATERIALS, AMERICAN CHEMICAL SOCIETY, US, vol. 26, no. 14, 22 July 2014 (2014-07-22), US , pages 4230 - 4237, XP093107228, ISSN: 0897-4756, DOI: 10.1021/cm501596s *

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