WO2023200324A1 - Dispositif pour l'analyse d'échantillons liquides - Google Patents

Dispositif pour l'analyse d'échantillons liquides Download PDF

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Publication number
WO2023200324A1
WO2023200324A1 PCT/MX2022/050033 MX2022050033W WO2023200324A1 WO 2023200324 A1 WO2023200324 A1 WO 2023200324A1 MX 2022050033 W MX2022050033 W MX 2022050033W WO 2023200324 A1 WO2023200324 A1 WO 2023200324A1
Authority
WO
WIPO (PCT)
Prior art keywords
capillary
analysis
discs
liquid samples
capillary holder
Prior art date
Application number
PCT/MX2022/050033
Other languages
English (en)
Spanish (es)
Inventor
Jesús Raúl BELTRÁN RAMÍREZ
Original Assignee
Beltran Ramirez Jesus Raul
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beltran Ramirez Jesus Raul filed Critical Beltran Ramirez Jesus Raul
Publication of WO2023200324A1 publication Critical patent/WO2023200324A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/88—Investigating the presence of flaws or contamination
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

Definitions

  • the present invention is related to the technical field of mechanics, electronics, physical-chemical analyses, laboratory samples and more specifically sample analysis methods, since it provides a device for analysis of liquid samples.
  • the method further comprises a light source that emits light of a specific spectral distribution, the light source is placed on one side of the path, the containers are at least partially transparent or translucent to light in the specific spectral distribution , the fluid or liquid being at least partially transparent or translucent to light in the specific spectral distribution.
  • the method also provides a camera that includes a CMOS (complementary metal semiconductor memory) electronic circuit to detect light in the specific spectral distribution emitted by the light source, the camera defines a field of view, the path of travel and intercepts the field of view, causing the electronic circuit to emit a digital image comprising a specific number of pixels, the camera recording a sequence of digital images as the container passes between the light source and the camera, selecting a portion of each of the digital images, the part that substantially corresponds to the outline of a specific container, transmitting each of the parts to a digital image processing unit and finally, processing the part of the digital image sequence to detect unwanted objects or failures in the specific container.
  • CMOS complementary metal semiconductor memory
  • the document cited above refers to a device for detecting unwanted objects or failures through the use of light emitters and receivers, but does not show evidence of having a rotating base for placing containers that has different sections. which can rotate independently, nor does it describe that it has a dispenser with vertical movement for placing the reagent and the liquid sample to be analyzed in each of the containers found in the different sections, nor does it refer to that The operation is through a light source and a receiver connected to an external processor.
  • the previous document refers to an apparatus for separating a compound from a liquid sample, but does not describe have a rotating base for placing samples with different sections, where each section has independent movement, nor does it detail having a dispenser that has vertical movement to place the reagent and the sample to be analyzed in the different sections in which they are stored. Where the sample containers are located, another characteristic that is not evident in the previous document is that the preparation, the application of the reagent and the placement of the sample are carried out at the same point.
  • the purpose of the present invention is to provide a device for analysis of liquid samples, which has a rotating base with different sections for placing a plurality of capillaries in each of its sections.
  • Another object of the present invention is to provide a device for analysis of liquid samples, which allows each of the sections of the rotating base to rotate independently.
  • An additional object of the present invention is to provide a device for analysis of liquid samples with a dispenser that has vertical movement to move between the different sections of the rotating base.
  • Another object of the present invention is to provide a device for analysis of liquid samples that allows the preparation, placement of the liquid sample, application of the reagent and carrying out the analysis of the sample at the same point.
  • An additional object of the present invention is to provide a device for analysis of liquid samples that has an integrated light emitter and receiver for the analysis of the samples connected to an external processor.
  • Figure 1 shows the transparency of a top perspective view of the device for analysis of liquid samples.
  • Figure 2 shows the transparency of a front perspective view of the device for analysis of liquid samples.
  • Figure 3 shows a side perspective view of the device for analysis of liquid samples.
  • Figure 4 shows a rear perspective view of the structure of the device for analysis of liquid samples.
  • Figure 5 shows a side perspective view of the capillary holder of the device for analysis of liquid samples.
  • Figure 6 shows a rear perspective view of the capillary holder of the device for analysis of liquid samples, without capillaries.
  • Figure 7 shows a transparent rear view of the capillary holder of the device for analysis of liquid samples, without capillaries.
  • Figure 8 shows a cross-sectional view of the capillary holder of the device for analysis of liquid samples.
  • Figure 9 shows a side view of the guide of the device for analysis of liquid samples.
  • Figure 10 shows a top perspective view of the guide of the device for analysis of liquid samples.
  • Figure 11 shows a top view of the guide of the device for analysis of liquid samples.
  • Figure 12 shows a detailed view of the guide of the device for analysis of liquid samples, with the elevator.
  • Figure 13 shows a rear perspective view of the elevator of the device for analysis of liquid samples.
  • Figure 14 shows a front perspective view of the elevator of the device for analysis of liquid samples.
  • Figure 15 shows a detailed view of the support of the device for analysis of liquid samples, with the analysis elements.
  • Figure 16 shows a detailed view of the analysis elements of the device for analysis of liquid samples.
  • Figure 17 shows a view of the capillary of the device for analysis of liquid samples.
  • the device for analysis of liquid samples is made up of a structure (1) that is prismatic in shape, preferably rectangular and with one of the sides exposed; a cover (2) is installed on the side of the structure (1) that is uncovered; A handle (15) is installed on the outside of the lid (2), this configuration allows said lid (2) to be opened and closed.
  • At least one cooling element (3) which is preferably a Peltier plate, is installed in the lower part of the interior of the structure (1), which is configured to maintain a certain temperature inside the device for analysis. of liquid samples.
  • a switch (4) is installed on the outside of the structure (1), preferably on the front face, which is configured to activate the cooling element (3); a sensor (not illustrated) which is preferably a thermocouple, is installed inside the structure (1), and is configured to detect the temperature inside said structure (1); A screen (5) which is preferably LCD (Liquid Crystal Display) is installed on the outside of the structure (1) and is configured to display the temperature inside said structure (1).
  • a base (6) which is preferably circular in shape, is installed in the lower part, inside the structure (1); At least one capillary holder (7) is installed in the upper part of the base (6).
  • the capillary holder (7) is made up of at least two sections made up of two discs (8) which have a perforation (9) in the center; a plurality of holes (10) are found on the surface of the outer periphery of the upper face of the discs (8) passing through said discs (8) from side to side; a cylinder (11), which is preferably hollow inside, is configured to install a disc (8) at each of its ends; a motor (12) is installed inside the cylinder (11) and is configured to transmit a rotary movement in the capillary holder (7); a capillary (13) which is cylindrical in shape, hollow inside and closed at the bottom is placed in each hole (10); said capillaries (13) are configured to store liquid samples.
  • the discs (8) at the top are smaller, so that the holes (10) are free to place the capillaries. (13), where each additional capillary holder (7) has a motor (12) installed, as well as the same number of holes (10) as the capillary holder (7) that is installed in the base (6).
  • a platform (14) is installed on one side of the base (6), preferably in the direction of the cover (2);
  • a guide (16) is installed vertically in the upper part of the platform (14), so that the face open of the guide (16) is in the direction of the capillary holder (7);
  • some rails (17) are located longitudinally in the middle part of the interior of the front face and the rear face of the guide (16);
  • some slots (18) are found longitudinally inside the guide (16) parallel to the sides of the rails (17);
  • a zipper (19) is installed inside one of the slots (18).
  • An elevator (20) of prismatic shape, preferably quadrangular and which is hollow inside, has a projection (21) on each of its side faces; the projections (21) are configured to install the elevator (20) inside the guide (16), assembling said projections (21) on the rails (17); a rotating element (not illustrated) is installed inside the elevator (20); a pinion (22) is installed on the rotating element (not shown), said pinion (22) is configured to assemble with the rack (19); The rotating element (not illustrated) is configured to transmit rotary movement to the pinion (22) and by means of the rack (19) move the elevator (20) within the guide (16) up or down to align it to the different heights at which the capillary holders (7) are located.
  • An actuator (23) is installed inside the elevator (20); a support (24) is installed vertically on the actuator stem (23); The actuator (23) is configured to transmit linear movement forward or backward in the support (24) and be able to move it to the required distance to bring it closer to the capillaries (13) that are in the capillary holder (7).
  • a plate (31) is placed perpendicularly on the rear face of the support (24) in the upper part, on said plate (31) a suction element (25) is placed, which preferably has a fork shape at one of its ends.
  • the part of the suction element (25) that is shaped like a fork is configured to connect to hoses (not shown) that are located in the containers (not shown) that store the liquid samples that will be analyzed.
  • An injection element (26) that preferably has the shape of an inverted "U” is installed at one of its ends to the end of the suction element (25) that protrudes from the support (24);
  • the suction element (25) is configured to supply liquid samples that are in the suction element (25) and expel said samples through the injection element (26) into the capillary (13), for subsequent analysis.
  • the duct (28) is configured to introduce an optical fiber (not illustrated) and preferably the end that is close to the injection element (26) is bent, positioning it in the same direction and being able to introduce it into the capillary (13) in which it is located.
  • said injection element (26); a receiver (29) is installed at the end of the duct (28) that is aligned with the injection element (26), said receiver (29) is connected to the optical fiber (not illustrated); a light emitter (30) that is preferably The LED (Light Emitting Diode) is installed in the lower part of the front face of the support (24), aligned with the lower part of the receiver (29).
  • This configuration allows light to be transmitted through the capillary ( 13) that contains the liquid sample, and the receiver (29) captures the distortion of light when there are particles in said liquid sample, and thus sends the analysis information through the optical fiber (not illustrated) to a computer equipment (not shown) or to a smart device (not shown).
  • the motor (12) and the rotating element can be an electric motor, a gear motor, a servo motor or a stepper motor.
  • the actuator (23) is preferably linear and can be pneumatic, electric or hydraulic.
  • a potentiometer (not illustrated) is installed on the outside of the structure (1) which is configured to regulate the operating temperature of the cooling medium (3).
  • a power source (not illustrated), which may be an electrical cord, a battery, a portable charger and/or a combination of the above, is installed inside the structure (1) and is configured to energize the electrical components of the device for analysis of liquid samples.
  • a general switch (not illustrated) is installed on the outside of the structure (1) which is configured to transmit electrical energy from the power source. power and activate all electrical and electronic components.
  • a communication unit (not illustrated) that can be through Bluetooth, WiFi (Wireless Fidelity) or UWB (Ultra Wide Band), is installed inside the structure (1 ), and is configured to control the operating parameters, as well as to view in real time and remotely the status of the device for liquid sample analysis through an intelligent device such as a computer, a tablet and/or a mobile phone. .
  • a microcontroller (not illustrated) is installed inside the structure (1) and is configured for the control and operation of the electronic components.
  • a pump (not illustrated) which is preferably peristaltic, can be installed inside the structure (1) that is configured to inject the liquid samples to the suction element (25).
  • Example 1 Filling and use of the device for analysis of liquid samples.
  • the hoses found in the liquid sample containers are taken and connected to the suction element (26), subsequently the main switch is activated (not illustrated) and the operating temperature of the cooling element (3) by means of the potentiometer (not illustrated), once the above is done, wait for the temperature inside the structure (1) to be the selected one, which is displayed on the screen (5). Once the temperature reached the selected parameter, the samples were analyzed.
  • the rotating element (not illustrated) will move the elevator (20) along the guide (16) until it is placed at the height where the capillary holder (7) is located and by means of the actuator (23) the support (24) will be brought closer to the capillary (13) to position the injection element (26) and the receiver (29) on said capillary (13), the liquid sample is introduced and the light emitter (30) is activated so that the receiver (29) performs the analysis detecting the existence of particles inside the supplied sample.
  • the motor (12) of the capillary holder (7) rotates to position another capillary in the direction of the injection element (26) and perform a new analysis. The same operation is repeated until all the samples programmed in the device for liquid sample analysis are completed.

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

Selon l'invention, un dispositif pour l'analyse d'échantillons liquides comprend une base rotative pour placer des capillaires, un système d'injection et un système de détection, la base rotative étant formée de divers porte-capillaires empilés verticalement qui comportent respectivement deux disques, un cylindre interne et un moteur, pouvant, donc, tourner, de manière indépendante, et les disques supérieurs présentant une taille inférieure à celle des disques inférieurs pour faciliter l'accès aux capillaires. Le système d'injection présente un mouvement vertical et horizontal permettant son positionnement de manière sélective dans chaque porte-capillaire, ledit système ayant donc accès à tous les capillaires. Le système de détection se compose d'un émetteur et d'un récepteur de lumière qui se trouvent situés à côté du système d'injection. Le tout est connecté à un processeur externe par le biais d'un système de communication.
PCT/MX2022/050033 2022-04-12 2022-04-12 Dispositif pour l'analyse d'échantillons liquides WO2023200324A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MXMX/A/2022/004490 2022-04-12
MX2022004490 2022-04-12

Publications (1)

Publication Number Publication Date
WO2023200324A1 true WO2023200324A1 (fr) 2023-10-19

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/MX2022/050033 WO2023200324A1 (fr) 2022-04-12 2022-04-12 Dispositif pour l'analyse d'échantillons liquides

Country Status (1)

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WO (1) WO2023200324A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4287155A (en) * 1980-06-16 1981-09-01 Eastman Kodak Company Sample tray and carrier for chemical analyzer
US20060159587A1 (en) * 2005-01-19 2006-07-20 Beckman Coulter, Inc. Automated clinical analyzer with dual level storage and access
EP1703285A2 (fr) * 2005-02-25 2006-09-20 Sysmex Corporation Procédé de contrôle d'appareil de mesure et appareil de mesure
WO2014144640A1 (fr) * 2013-03-15 2014-09-18 Abbott Laboratories Analyseurs de diagnostic automatisés ayant des corbeilles agencées verticalement et procédés associés

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4287155A (en) * 1980-06-16 1981-09-01 Eastman Kodak Company Sample tray and carrier for chemical analyzer
US20060159587A1 (en) * 2005-01-19 2006-07-20 Beckman Coulter, Inc. Automated clinical analyzer with dual level storage and access
EP1703285A2 (fr) * 2005-02-25 2006-09-20 Sysmex Corporation Procédé de contrôle d'appareil de mesure et appareil de mesure
WO2014144640A1 (fr) * 2013-03-15 2014-09-18 Abbott Laboratories Analyseurs de diagnostic automatisés ayant des corbeilles agencées verticalement et procédés associés

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ALBERTO MORALES-VILLAGRAN ET AL.: "A Capillary Fraction Collector Coupled to a Fluorescence Reader: A Novel Device to Continuously Quantify Glutamate During Microdialysis", NEUROCHEMICAL RESEARCH, vol. 37, no. 7, 3 August 2012 (2012-08-03), pages 1457 - 1464, XP035066131, ISSN: 1573-6903, DOI: 10.1007/s11064-012-0736-Y *

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