WO2023181741A1 - Module capteur, dispositif de type embout buccal, et système - Google Patents

Module capteur, dispositif de type embout buccal, et système Download PDF

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Publication number
WO2023181741A1
WO2023181741A1 PCT/JP2023/005759 JP2023005759W WO2023181741A1 WO 2023181741 A1 WO2023181741 A1 WO 2023181741A1 JP 2023005759 W JP2023005759 W JP 2023005759W WO 2023181741 A1 WO2023181741 A1 WO 2023181741A1
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Prior art keywords
sensor
storage chamber
flow path
enzyme
mouthpiece
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PCT/JP2023/005759
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English (en)
Japanese (ja)
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信行 久保井
保久登 三木
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ソニーセミコンダクタソリューションズ株式会社
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Publication of WO2023181741A1 publication Critical patent/WO2023181741A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems

Definitions

  • the present disclosure relates to sensor modules, mouthpiece-type devices, and systems.
  • VR Virtual Reality
  • the market size of VR is expected to expand to the same extent as mobile in the next few years, and it is expected that it will become widespread as a general technology in the world.
  • some users may feel "sickness" similar to motion sickness when continuing to play VR. Therefore, for the spread of VR, it is desired to develop a technology that detects signs of motion sickness and prevents or suppresses motion sickness. In developing this technology, detection of signs of intoxication is particularly important.
  • Patent Document 1 discloses a device that detects the concentration of amylase (enzyme) in saliva in the oral cavity by utilizing the fact that amylase, one of the enzymes in saliva, is a tracer of pleasure and discomfort during symptoms of intoxication. is proposed. Specifically, it includes an electron-generating capsule that generates electrons by reacting with an enzyme, and a concave structure that holds the electron-generating capsule, and measures the concentration of the enzyme by measuring the current caused by the generated electrons. A sensor module has been proposed.
  • the sensor module described in Patent Document 1 further includes a movable shielding plate that shields and opens the opening of the concave structure, and allows the shielding plate to open and close the opening of the concave structure, thereby preventing the introduction of liquid into the opening. It's in control.
  • the sensor module described in Patent Document 1 when detecting the concentration of enzymes in saliva, the sensor module is mounted on the side wall surface of the mouthpiece, and the sensor module is mounted on the side wall surface of the mouthpiece, and the Saliva is adapted to be introduced into the recessed structure of the sensor module.
  • the sensor module needs to be installed at a certain distance from the orifice. Therefore, even if the opening of the concave structure is opened, saliva may not flow into the opening of the concave structure, and the enzyme concentration in saliva may not be measured appropriately.
  • An object of the present disclosure is to provide a sensor module, a mouthpiece type device, and a system that can sensitively measure the concentration of an enzyme in a liquid to be detected.
  • the sensor module of the present disclosure includes (a) a flow channel whose one open end is open toward the outside, and (b) a storage chamber that acquires and stores a liquid to be detected from the outside via the flow channel. , (c) a movable wall that forms the wall of the storage chamber and is deformable in the direction in which the volume of the storage chamber changes; and (d) a wall surface facing the movable wall of the storage chamber or opposite to the flow path side of the storage chamber. and an enzyme sensor that is placed on the side wall and measures the concentration of enzyme in the liquid.
  • the mouthpiece-type device of the present disclosure includes (a) a channel in which one open end is open toward the outside, and (b) a storage chamber that acquires and stores a liquid to be detected from the outside through the channel. , (c) a movable wall that forms the wall of the storage chamber and is deformable in the direction in which the volume of the storage chamber changes; (d) and a wall side facing the movable wall of the storage chamber or opposite to the flow path side of the storage chamber.
  • a sensor module that is disposed on a side wall and includes an enzyme sensor that measures the concentration of an enzyme in a liquid; and (e) a mouthpiece in which the sensor module is mounted.
  • the system of the present disclosure includes (a) a flow channel whose one open end is open toward the outside, (b) a storage chamber that acquires and stores a liquid to be detected from the outside via the flow channel, (c) ) a movable wall that forms the wall of the storage chamber and is deformable in the direction in which the volume of the storage chamber changes; (d) a wall side facing the movable wall of the storage chamber or a wall side opposite to the channel side of the storage chamber; (e) a sensor module including an enzyme sensor arranged in a liquid to measure the concentration of enzyme in a liquid and a transmitter that transmits a signal output from the enzyme sensor; (f) a mouthpiece in which the sensor module is mounted; (g) an external device that receives a signal transmitted from the mouthpiece type device and starts driving a predetermined function using the received signal as a trigger.
  • FIG. 1 is a diagram showing the overall configuration of a mouthpiece type device according to a first embodiment.
  • FIG. 2 is a diagram showing a cross-sectional configuration of the mouthpiece type device when cut along a plane parallel to the yz plane of FIG. 1.
  • FIG. 2 is a diagram showing the overall configuration of a sensor module. It is a figure showing the cross-sectional structure of the mouthpiece type device concerning a modification.
  • 4 is a diagram illustrating a cross-sectional configuration of the sensor unit when cut along a plane parallel to the yz plane of FIG. 3.
  • FIG. It is a figure which shows the cross-sectional structure of a movable wall when it is in a curved state.
  • FIG. 1 is a diagram showing the overall configuration of an enzyme sensor. It is a figure showing the whole structure of an enzyme sensor concerning a modification. It is a figure showing the cross-sectional structure of the sensor unit when it is in a flat state.
  • FIG. 17 is a diagram showing a cross-sectional configuration of the sensor unit when cut along a plane parallel to the xy plane of FIG. 16.
  • FIG. It is a figure showing the cross-sectional structure of the sensor unit concerning modification (2).
  • FIG. 3 is a diagram showing a cross-sectional configuration of the sensor unit in a curved state. It is a figure showing the whole structure of a sensor module concerning modification (3). It is a figure showing the cross-sectional structure of the sensor unit concerning modification (4).
  • FIG. 2 is a diagram showing a schematic configuration of a system according to a second embodiment.
  • FIG. 3 is a diagram showing the internal configuration of a GVS device.
  • FIG. 1 is a diagram showing the overall configuration of a mouthpiece type device 1 according to the first embodiment.
  • the mouthpiece type device 1 targets a user who is playing VR, and is attached to the user to continuously measure the concentration of enzymes in saliva and time-series monitor the signs of motion sickness during continuous VR play. It is a device for Examples of enzymes include amylase.
  • a mouthpiece type device 1 includes a mouthpiece 2.
  • the mouthpiece 2 is a lower jaw mouthpiece that is detachably attached to the lower jaw of a person to be measured.
  • FIG. 2 is a diagram showing a cross-sectional configuration of the mouthpiece type device 1 when cut along a plane parallel to the yz plane of FIG.
  • the mouthpiece 2 is formed into a substantially U-shape in plan view in accordance with the lower jaw row of teeth of the person to be measured so as to cover the crowns of all teeth and the upper part of the gums of the lower jaw row of teeth.
  • a sports mouthpiece can be adopted.
  • An example of the thickness of the mouthpiece 2 is, for example, about 3 mm.
  • a pressure sensor 3 is provided on the tongue-side or palate-side wall surface (hereinafter also referred to as "first wall surface S1") of the surface of the mouthpiece 2 that contacts the tooth crown (hereinafter also referred to as “inner surface”).
  • sensor modules 4L and 4R, and a logic unit 5 (“control unit” in a broad sense) are arranged.
  • a plurality of orifices 6 are formed at the positions of the mouthpiece 2 where the sensor modules 4L, 4R are arranged.
  • FIG. 1 illustrates a case where six cylindrical through holes penetrating the first wall surface S1 of the mouthpiece 2 are formed as the orifice 6 at each position where the sensor modules 4L and 4R are arranged.
  • the saliva 8 in the oral cavity enters the orifice 6 and the saliva 8 in the orifice 6 is formed. is formed at a position facing one open end 11 of the flow path 12 so as to enter into the flow path 12 shown in FIG.
  • a power source/RF section 7 is disposed on the cheek-side or lip-side wall (hereinafter also referred to as "second wall surface S2") of the inner surface of the mouthpiece 2.
  • the mouthpiece 2 may have a configuration in which a function for measuring the external environment, such as a GPS receiver or an acceleration sensor, is implemented.
  • the pressure sensor 3 is disposed on the first wall surface S1 of the mouthpiece 2 at a portion that is in contact with both the back side of the front teeth and the top surface of the front teeth.
  • the pressure sensor 3 detects pressure applied to a portion of the mouthpiece 2 located behind the front teeth or a portion located on the top surface of the front teeth. Thereby, when the person to be measured presses the pressure sensor 3 with his tongue or bites the pressure sensor 3, a signal corresponding to the pressure is output from the pressure sensor 3. The output signal is input to the logic section 5.
  • the sensor modules 4L and 4R are disposed on the first wall surface S1 of the mouthpiece 2 at the portions that contact the back sides of the left and right molars (hereinafter also referred to as “molar contact portions").
  • the sensor modules 4L and 4R measure the concentration of an enzyme (amylase) in the saliva 8 (in a broad sense, "liquid to be measured") of a person to be measured. Note that since the sensor modules 4L and 4R have the same structure although the left and right sides are reversed, only the structure of the sensor module 4L will be described below. As shown in FIG. 3, the sensor module 4L includes a flat case 9 that accommodates each component of the sensor module 4L.
  • the thickness direction of the flat sensor module 4L thickness direction of the flat sensor module 4L (thickness direction of the flat plate) will be referred to as the "y direction", and the direction along one side of the flat sensor module 4L (one side of the flat plate) will be referred to as the "y direction”.
  • the direction along the other side is called the "z direction”.
  • the xz plane is along the molar contact area of the first wall surface S1
  • the z direction is parallel to the vertical direction (direction from the bottom to the top)
  • the y direction is parallel to the width direction (from the buccal or labial side to the tongue).
  • the first wall surface S1 is disposed at the back tooth contacting portion of the first wall surface S1 so as to be parallel to the side or the direction toward the palate side.
  • the housing 9 (sensor module 4L) is configured to be detachable from the mouthpiece 2.
  • FIG. 2 it is possible to adopt a configuration in which a recess 2a into which the housing 9 can be fitted is formed in the molar contact portion of the first wall surface S1, and the housing 9 is fitted and fixed into the recess 2a. .
  • the mouthpiece 2 can be reused by replacing the sensor module 4L.
  • the first embodiment shows an example in which the sensor module 4L is mounted on the side wall surface (first wall surface S1) of the mouthpiece 2, other configurations may also be adopted.
  • it may be configured to be mounted within the side wall of the mouthpiece 2.
  • An example of the dimensions of the housing 9 is a configuration in which the length in the z direction is 10 mm, the length in the x direction is 10 mm, and the length in the y direction is 2 mm.
  • the size in side view can be made to be about the size of one molar tooth.
  • the length in the y direction can be mounted in a sports mouthpiece (a relatively thick mouthpiece).
  • resin can be used as the material for the housing 9, for example.
  • a plurality of sensor units 10 are arranged in an array.
  • six sensor units 10 are arranged in an array with two rows in the z direction (vertical direction in FIG. 3) and three rows in the x direction (direction from the front side to the back side in FIG. 3). is exemplified.
  • the sensor unit 10 has one open end 11 that is open toward the outside on the y-direction side (right side in FIG. 5) of the sensor module 4L. It has a cylindrical flow path 12 extending to the opposite side. Thereby, when the sensor module 4L is mounted on the mouthpiece 2, one opening end 11 of the flow path 12 is configured to open toward the space within the orifice 6 of the first wall surface S1.
  • FIG. 5 is a diagram showing a cross-sectional configuration of the sensor unit 10 when cut along a plane parallel to the yz plane of FIG. Further, the other open end 13 of the flow path 12 is opened toward the inside of a storage chamber 14 formed within the sensor unit 10.
  • An example of the diameter of the flow path 12 is, for example, about 0.1 mm.
  • the sensor unit 10 includes a storage chamber 14 in which the other open end 13 of the flow path 12 is opened toward the inside.
  • the storage chamber 14 becomes a semi-cylindrical space extending along the y direction (that is, the same direction as the flow path 12) when the movable wall 15 is in a curved state as described later.
  • the saliva 8 in the orifice 6 enters the flow path 12, and the entered saliva 8 can flow through the flow path 12, allowing the saliva to enter the storage chamber 14 from the outside via the flow path 12. It is now possible to acquire and accommodate 8.
  • the heights of the storage chamber 14 and the flow path 12 on the z-direction side and the opposite side are the same.
  • the heights of the storage chamber 14 and the flow path 12 on the z-direction side are also the same.
  • the length in the x direction is 1 mm
  • the length in the y direction is 1 mm
  • the length in the z direction is 0.1 mm.
  • a wall surface on the z-direction side (upper side in FIG. 5) of the storage chamber 14 is formed of a movable wall 15 that can be deformed in a direction in which the volume of the storage chamber 14 changes.
  • the movable wall 15 includes a pair of soft electrodes 16 and 17 and a ferromagnetic material 18 sandwiched between the pair of soft electrodes 16 and 17, as shown in FIGS. 6 and 7.
  • the center part of the movable wall 15 in the x direction moves in the z direction (upward in FIG. 5).
  • a semi-cylindrical shape hereinafter also referred to as a "curved state"
  • a voltage between the pair of soft electrodes 16 and 17 the inside of the ferromagnetic material 18 is polarized and Maxwell stress is generated, so that the center portion of the movable wall 15 in the x direction protrudes in the z direction.
  • the movable wall 15 curves.
  • the storage chamber 14 becomes a semi-cylindrical space, and the volume of the storage chamber 14 becomes maximum.
  • the ferromagnetic material 18 for example, a conductive polymer containing a ferromagnetic material can be used.
  • the pair of soft electrodes 16 and 17, for example carbon black electrodes can be used.
  • a piezo element using a lead-free ferromagnetic material can also be used.
  • a ferromagnetic material for example, an alloy containing bismuth (Bi) can be used.
  • a shape memory alloy can also be used.
  • the movable wall 15 when the application of voltage between the pair of soft electrodes 16 and 17 is stopped, the movable wall 15 is in a state in which it is deformed into a flat plate shape (hereinafter referred to as “ (also called “flat plate state”).
  • the surface opposite to the z-direction side of the movable wall 15 (the lower surface in FIG. 6; hereinafter also referred to as "lower surface S3") and the storage chamber
  • the z-direction side of the enzyme sensor 14 and the opposite wall surface in FIG.
  • the lower wall surface hereinafter also referred to as "bottom surface S4"
  • bottom surface S4 the opening of the concave structure 22 of the enzyme sensor 19 shown in FIG.
  • This example shows the case of covering. That is, when the movable wall 15 is deformed in a direction in which the volume of the storage chamber 14 becomes smaller, the movable wall 15 contacts the enzyme sensor 19 and releases the electron generating capsule 24 (in a broad sense) arranged in the concave structure 22. It is configured to cover the "reaction section" (see FIG. 8). As a result, the volume of the storage chamber 14 becomes zero, and the volume of the storage chamber 14 becomes the minimum.
  • the enzyme sensor 19 since the electron generating capsule 24 (reaction part) of the enzyme sensor 19 is covered with the movable wall 15 and does not come into contact with the saliva 8, the enzyme sensor 19 does not need to start measuring the concentration of the enzyme (amylase).
  • the thickness of the movable wall 15 in the z direction is such that when the movable wall 15 is in a flat state, the side surface of the movable wall 15 closes the open end (the other open end 13) of the flow path 12 on the accommodation chamber 14 side.
  • the diameter of the flow path 12 was set to be greater than the diameter of the flow path 12 so that the diameter of the flow path 12 could be increased.
  • an enzyme sensor 19 is arranged on the wall surface (bottom surface S4) side (lower side in FIG. 5) facing the movable wall 15 of the storage chamber 14.
  • the enzyme sensor 19 forms the bottom surface S4 of the storage chamber 14.
  • the enzyme sensor 19 measures the concentration of enzyme (amylase) in the saliva 8 contained in the storage chamber 14 .
  • the enzyme sensor 19 includes a pair of electrodes 20, 21, an electron transfer layer 23 having a concave structure 22, and an electron transfer layer 23 having a concave structure 22, which is sandwiched between the pair of electrodes 20, 21. and an electron generating capsule 24 held inside.
  • the amount of enzyme (amylase) can be measured by measuring the current generated by the electrons generated in the electron generating capsule 24.
  • the pair of electrodes 20 and 21 for example, an Ag electrode or a C electrode can be used.
  • the electron transport layer 23 for example, a layer containing a gel-like mediator can be adopted.
  • a layer containing a gelled potassium ferricyanide solution (electrolyte) may be mentioned.
  • the electron-generating capsule 24 for example, a spherical starch ball having a spherical center portion 25 containing glucose oxidase, maltase, and PMEH wrapped in a thin starch film 26 can be adopted.
  • the electron-generating capsule 24 (starch ball) and the gel-like mediator constitute a reaction section of the enzyme sensor 19. Thereby, the enzyme in the saliva 8 generates electrons from the positive electrode side of the pair of electrodes 20 and 21 through an oxidation/reduction reaction starting from the reaction with starch.
  • an enzyme sensor including a pair of electrodes 27 and 28 and an electron generation layer 29 sandwiched between the pair of electrodes 27 and 28 can also be used.
  • the amount of enzyme (amylase) can be measured by measuring the current due to electrons generated in the electron generation layer 29.
  • the electron generation layer 29 for example, a layer containing starch, PQQ glucose dehydrogenase, and a mediator can be adopted.
  • the movable wall 15 Let be a flat plate. Then, the other open end 13 of the flow path 12 is closed with the side surface of the movable wall 15, and the bottom surface S4 of the storage chamber 14 is covered with the lower surface S3 of the movable wall 15. Thereby, the saliva 8 does not enter the storage chamber 14, and the enzyme sensor 19 does not come into contact with the saliva 8.
  • a voltage is applied between the pair of soft electrodes 16 and 17 to bend the movable wall 15 as shown in FIGS. 6 and 11.
  • the movable wall 15 is in a curved state, the other open end 13 of the flow path 12 that was blocked by the side surface of the movable wall 15 is opened, and the storage chamber that was covered by the lower surface S3 of the movable wall 15 is opened. 14 bottom surface S4 is exposed.
  • the volume of the storage chamber 14 increases, and a negative pressure is generated within the storage chamber 14 due to the increase in volume.
  • the saliva 8 in the orifice 6 is drawn into the flow path 12 by the negative pressure generated in the storage chamber 14, and the drawn saliva 8 is stored in the storage chamber 14 via the flow path 12. Then, when the saliva 8 is accommodated in the accommodation chamber 14, the concentration of enzyme (amylase) in the accommodated saliva 8 is measured by the enzyme sensor 19. At this time, since a negative pressure is generated in the storage chamber 14, it is also possible to suppress the material of the electron-generating capsule 24 (reaction part) of the enzyme sensor 19 from seeping into the oral cavity.
  • the length La of the flow path 12 in the direction in which the flow path 12 extends is preferably shorter than the length Lb of the storage chamber 14 (La ⁇ Lb).
  • the saliva 8 can be contained in the storage chamber 14 instantaneously (for example, in 10 ⁇ 6 seconds), and the Enzyme (amylase) concentration measurement can be started instantly.
  • the saliva 8 can be instantly accommodated in the accommodation chamber 14 due to the negative pressure caused by the increase in the volume of the accommodation chamber 14, as shown in the simulation results of the liquid level movement, as shown in FIGS. 12 and 13. be understood. That is, as shown in FIG.
  • the moving speed v(t) of the saliva 8 at the elapsed time t after the movable wall 15 is deformed into the shape in which the volume of the storage chamber 14 is maximized is calculated by the following formula (2). It is expressed as Here, V0 is the volume of air in the flow path 12 when the movable wall 15 is in a flat state, and V(0) is the volume of the storage chamber 14 when the movable wall 15 is in a curved state. Then, a simulation of the liquid level movement was performed according to the above equation (2), and the simulation results shown in FIGS. 12 and 13 were obtained.
  • the vertical axis represents the moving distance of the saliva 8
  • the horizontal axis represents the elapsed time t after the movable wall 15 changes from the flat state to the curved state.
  • FIG. 12 it can be seen that when La ⁇ Lb, the saliva 8 instantly reaches a position 0.9 mm from the entrance of the storage chamber 14 (the other open end 13).
  • the power supply/RF section 7 includes a power supply 30 and a transmitter 31.
  • the power supply 30 is a power supply that supplies power to the logic section 5 and the transmitter 31.
  • the power source 30 for example, a lithium ion battery that can output a voltage of about 10V can be used.
  • the transmitter 31 is controlled by the logic unit 5 and transmits a signal to an external device by wireless communication or wired communication.
  • the wireless communication communication based on a wireless communication standard such as Bluetooth (registered trademark) can be adopted, for example.
  • the logic unit 5 acquires the signal output from the pressure sensor 3, drives the movable wall 15, acquires the signal output from the enzyme sensor 19, and transmits the signal to an external device via the transmitter 31.
  • the logic section 5 for example, an integrated circuit including a transistor can be used.
  • the logic unit 5 starts the sensor modules 4L and 4R (step S101).
  • the logic unit 5 selects one sensor unit 10 (hereinafter also referred to as "first sensor unit 10") among the six sensor units 10 of the sensor module 4L.
  • step S102 Application of a voltage between the pair of soft electrodes 16 and 17 of the movable wall 15 (step S102) is started. That is, the transistor constituting the logic section 5 continuously applies a voltage (for example, 2V) for one minute to transform the movable wall 15 into a curved state. By applying the voltage, the logic unit 5 deforms the movable wall 15 into a curved state and increases the volume of the storage chamber 14 (step S103). As a result, a negative pressure is generated within the storage chamber 14, and saliva 8 within the orifice 6 is drawn into the storage chamber 14 via the flow path 12.
  • a voltage for example, 2V
  • Step S104 the reaction between the saliva 8 and the electron generating capsule 24 (reaction part) is started, and the measurement of the concentration of the enzyme (amylase) in the saliva 8 (amylase activity) is started.
  • the logic unit 5 accumulates the signal output from the enzyme sensor 19 of the first sensor unit 10 (an electric signal caused by electrons generated by the reaction between the saliva 8 and the electron-generating capsule 24) for one minute, and stores the accumulated 1 The minute signal is transmitted to the external device via the transmitter 31 (step S105). Subsequently, the logic section 5 stops applying the voltage between the pair of soft electrodes 16 and 17 (movable wall 15) of the first sensor unit 10, as shown at time t2 in FIG. 15 (step S106). , the control target is switched from the first sensor unit 10 to the next sensor unit 10 (i-th sensor unit, where i is any one of 2 to 6) (step S107), and the flow of steps S102 to S106 is repeated.
  • the transistor constituting the logic section 5 applies a voltage of 2V to each of the movable walls 15 of the plurality of sensor units 10 for one minute at a time, as shown at time t3 in FIG. Measure the concentration of (amylase).
  • the logic unit 5 causes one movable wall 15 of the movable walls 15 included in the plurality of sensor units 10 to perform increase/decrease control to increase and decrease the volume of the storage chamber 14, and also controls the volume of the storage chamber 14 for a predetermined period of time ( It can also be said that the movable wall 15 to which the increase/decrease control is performed is switched every time one minute (1 minute) elapses.
  • the concentration of the enzyme (amylase) in the saliva 8 in the oral cavity can be continuously measured by sequentially using the six sensor units 10 of the sensor module 4L.
  • the logic section 5 causes each of the movable walls 15 of the plurality of sensor units 10 forming the sensor modules 4L and 4R to sequentially perform increase/decrease control.
  • the logic section 5 causes each of the movable walls 15 of the plurality of sensor units 10 forming the sensor modules 4L and 4R to sequentially perform increase/decrease control.
  • the sensor unit 10 to be controlled (that is, the sensor unit 10 that measures the enzyme concentration) is configured to be sequentially switched from the back tooth side to the front tooth side.
  • saliva 8 is secreted from the sublingual gland in the oral cavity. Therefore, in the initial stage of concentration measurement, the concentration of the enzyme (amylase) in saliva 8 can be measured with high sensitivity by using the sensor unit 10 on the molar side near the sublingual gland. Furthermore, saliva 8 secreted from the sublingual gland spreads into the oral cavity over time. Therefore, in the middle and late stages of concentration measurement, even if the sensor unit 10 on the anterior tooth side far from the sublingual gland is used, the sensitivity of measuring the concentration of the enzyme (amylase) in saliva 8 will not decrease. It's over.
  • a movable shielding plate that shields and opens the concave structure 22 of the enzyme sensor 19 is provided, and the shielding plate opens and closes the opening of the concave structure 22 to control the introduction of saliva 8 into the opening.
  • the sensor modules 4L and 4R must be installed at a certain distance from the orifice 6 in consideration of the movable range of the shielding plate. Therefore, even if the opening of the concave structure 22 is opened, the saliva 8 may not flow into the opening of the concave structure 22, and the concentration of amylase (enzyme) in the saliva 8 may not be measured appropriately.
  • the sensor modules 4L, 4R and the mouthpiece type device 1 there is a flow path 12 in which one opening end 11 is open toward the outside, and a flow path 12 that is connected to the outside through the flow path 12. and a storage chamber 14 that accommodates saliva 8 (liquid to be detected).
  • the enzyme sensor 19 is arranged on the wall surface side facing the wall 15 and measures the concentration of amylase (enzyme) in the saliva 8.
  • the concentration of amylase (enzyme) in the drawn saliva 8 can be measured by the enzyme sensor 19. Therefore, it is possible to provide the sensor modules 4L, 4R and the mouthpiece type device 1 that can measure the concentration of amylase (enzyme) in saliva 8 with high sensitivity.
  • the change in color of the reagent due to a chemical reaction (formation of CNP side chain) between amylase in saliva 8 and chromogen in the reagent is optically determined, and amylase in saliva 8 is
  • a method is adopted to measure the concentration of Specifically, using Nipro Co., Ltd.'s "Dry Clinical Chemistry Analyzer Salivary Amylase Monitor," the reagent was pressed under the tongue for 30 seconds, then the reagent was taken out of the mouth and placed into a special measuring device.
  • a reagent is inserted and measurement is performed optically.
  • the amylase concentration cannot be measured continuously because the reagent is inserted into the oral cavity each time the measurement is performed, and then the reagent is inserted into the measuring device, which makes it difficult to detect signs of motion sickness during VR play. Time series monitoring is not possible. In addition, it is difficult to accurately measure amylase concentration because it requires some skill in how to apply the reagent under the tongue.
  • the plurality of sensor units 10 are arranged in an array, and the sensor modules 4L and 4R are mounted on the mouthpiece 2. Then, each sensor unit 10 sequentially measures the concentration of amylase (enzyme). Thereby, by attaching the mouthpiece 2 to the lower jaw of the person to be measured, the concentration of amylase can be continuously measured, and signs of motion sickness can be monitored over a long period of time.
  • concentration of amylase enzyme
  • the enzyme sensor 19 is arranged on the wall surface (bottom surface S4) facing the movable wall 15, but other configurations may also be adopted.
  • the enzyme sensor 19 is added to the bottom surface S4 of the storage chamber 14, and the side wall surface S5 of the storage chamber 14 (the wall surface on the x direction side of the wall surface of the storage chamber 14,
  • a concave enzyme sensor may be arranged so as to form a wall surface opposite to the y-direction side, and a wall surface opposite to the y-direction side.
  • FIG. 17 is a diagram showing a cross-sectional configuration of the sensor unit 10 when cut along a plane parallel to the xy plane of FIG. 16.
  • FIG. 17 illustrates a case where the flow path 12 has a rectangular tube shape extending along the y direction.
  • the enzyme sensor 19 may be arranged on the wall surface of the storage chamber 14 on the side opposite to the channel 12 side. Specifically, as illustrated in FIG. It may also be arranged on the wall side of the area (2 areas).
  • the movable wall 15 when the movable wall 15 is in a flat state, the area on the flow path 12 side (hereinafter referred to as The movable wall 15 is illustrated as an example where the movable wall 15 is formed only in the "first region" (also referred to as the "flow path side region 33" (in a broader sense, the "first region").
  • the movable wall 15 forms the wall surface of the flow path side region 33 in the storage chamber 14, and when the movable wall 15 is deformed in a direction in which the volume of the storage chamber 14 becomes smaller (when it is in a flat state), the movable wall 15 becomes movable. It is configured to come into contact with a wall surface (bottom surface S4) facing the wall 15 to separate the vacuum region 32 and the flow path 12. This eliminates the need for the enzyme sensor 19 to start measuring the concentration of the enzyme (amylase).
  • the inside of the vacuum region 32 is in a vacuum state or a low pressure state lower than atmospheric pressure in a state where the movable wall 15 separates the flow path 12 and the vacuum region 32.
  • the vacuum state of the vacuum region 32 is realized, for example, by manufacturing the sensor modules 4L, 4R in a vacuum state or a low pressure environment.
  • the negative pressure generated within the accommodation chamber 14 due to the deformation of the volume of the accommodation chamber 14 and the vacuum state of the vacuum region 32 are reduced.
  • the saliva 8 in the orifice 6 can be drawn into the vacuum region 32 via the flow path 12 and the flow path side region 33 by the negative pressure caused by the flow path. Since the enzyme sensor 19 is arranged to surround the vacuum region 32, the contact area between the drawn saliva 8 and the enzyme sensor 19 can be increased, and the sensitivity of the enzyme sensor 19 can be improved.
  • the logic section 5 causes each of the movable walls 15 of the plurality of sensor units 10 forming the sensor modules 4L and 4R to deform in a direction that increases the volume of the storage chamber 14.
  • the logic section 5 may cause each of the sensor unit groups 34 including two or more sensor units 10 among the plurality of sensor units 10 to sequentially perform measurement operations. Good too. Examples of the measurement operation include an operation in which the movable walls 15 of two or more sensor units 10 included in the sensor unit group 34 simultaneously perform increase/decrease control.
  • the logic unit 5 is also configured to include a data average calculation circuit 35 that calculates the average of measurement results output from two or more enzyme sensors 19 included in the sensor unit group. That is, during a certain measurement time, the enzyme concentration is measured simultaneously using two or more sensor units 10 in the array, the measurement results (signals from the enzyme sensor 19) are averaged, and the averaged measurement is It is configured to output the results. Thereby, the signal strength can be increased and the detection sensitivity of the enzyme sensor 19 can be improved. Furthermore, noise components contained in the signal can be reduced, and the detection accuracy of the enzyme sensor 19 can be improved.
  • the flow path 12 is formed into a cylindrical shape (that is, the opening area of one opening end 11 of the flow path 12 is the same as the opening area of the other opening end 13).
  • Example is shown, but other configurations may also be adopted.
  • the opening area of the external opening end (one opening end 11) of the flow path 12 is made smaller than the opening area of the opening end (other opening end 13) on the storage chamber 14 side.
  • the shape of the channel 12 is a truncated cone
  • the diameter of the open end on the outside side (one open end 11) of the channel 12 is set to the diameter of the open end on the side of the storage chamber 14 (the other open end 13).
  • An example is a configuration in which the size is about 50% of the diameter (for example, about several tens of ⁇ m to 1 mm). Thereby, the ability to draw saliva 8 from the oral cavity into the flow path 12 can be improved.
  • FIG. 22 is a schematic configuration diagram of a system 100 according to the second embodiment of the present disclosure.
  • the system 100 is a system that starts measures to control the intoxication state (measures to avoid or suppress the intoxication in advance, etc.) when a user (person to be measured) who is playing VR shows signs of intoxication. be.
  • the system 100 includes a mouthpiece type device 101 and a GVS (Galvanic Vestibular Stimulation) device 102.
  • the mouthpiece type device 101 is the mouthpiece type device 1 according to the first embodiment.
  • the signal transmission destination of the transmitter 31 is the GVS device 102.
  • the GVS device 102 (“external device” in a broad sense) is attached to each of the left and right ears of the person to be measured, receives a signal transmitted from the transmitter 31 of the mouthpiece type device 101, and uses the received signal as a trigger. , starts driving a function (in a broad sense, "predetermined function") that takes measures to control the state of motion sickness during VR play.
  • the GVS device 102 may have a configuration including a communication section 103, a current application section 104, and electrodes 105, 106, and 107, as shown in FIG.
  • the communication unit 103 then receives a signal transmitted from the transmitter 31 of the mouthpiece type device 101.
  • the current applying unit 104 determines whether the concentration of enzyme (amylase) in the saliva 8 exceeds a predetermined threshold based on the signal received by the communication unit 103. In addition, if it is determined that the threshold has been exceeded, the current applying unit 104 applies a current to the head (in particular, the vestibular organ of the inner ear) of the subject through the electrodes 105 to 107 so as to suppress motion sickness during VR play. ).Start treatment by applying a weak current to the area. Electrodes 105-107 may be placed, for example, near the temple, in the neck area below the back of the ear, and near the mastoid process.
  • the GVS device 102 (external device) receives a signal transmitted from the mouthpiece type device 101, and uses the received signal as a trigger to perform VR play.
  • the system is configured to start driving a function (predetermined function) that performs treatment for controlling the state of motion sickness.
  • a function predetermined function
  • the concentration of enzyme (amylase) in the saliva 8 becomes high, it is possible to avoid or suppress the feeling of sickness. Therefore, it is possible to improve the sense of immersion of the person to be measured in VR.
  • the system 100 is configured to include the GVS device 102, but other configurations may be used. For example, if it is determined that the concentration of enzyme (amylase) exceeds a threshold based on a signal transmitted from the transmitter 31 of the mouthpiece type device 101 instead of the GVS device 102, the It may also be configured to include a device that outputs images, video effects, vibrations, smells, sounds, etc. that suppress motion sickness.
  • the mouthpiece type device 1 according to the first embodiment is used in the system 100 as the mouthpiece type device 101, but other configurations may be used. For example, a configuration using a mouthpiece type device 1 according to a modified example may be used.
  • the present technology can also have the following configuration.
  • a sensor module comprising: an enzyme sensor that is disposed on a wall surface of the storage chamber opposite to the movable wall or on a wall surface of the storage chamber opposite to the flow path side, and measures the concentration of enzyme in the liquid.
  • the enzyme sensor is a sensor that measures the concentration of amylase as the concentration of the enzyme.
  • the movable wall forms a wall surface of a first region that is a region on the flow path side of the region inside the storage chamber, and when the movable wall is deformed in a direction in which the volume of the storage chamber is reduced, the movable wall configured to contact a wall surface facing the wall to separate the flow path from a second region that is a region of the storage chamber on the opposite side to the flow path side;
  • the sensor module according to any one of (1) to (4), wherein the enzyme sensor is disposed on the wall side of the second region.
  • the inside of the second region is in a vacuum state or a low pressure state lower than atmospheric pressure in a state where the movable wall separates the second region and the flow path. sensor module.
  • a mouthpiece type device comprising: a mouthpiece on which the sensor module is mounted.
  • the mouthpiece type device (10) The mouthpiece type device according to (9) above, wherein the sensor module is mounted on a side wall surface or inside the side wall of the mouthpiece.
  • the sensor module includes a plurality of sensor units including the flow path, the storage chamber, the movable wall, and the enzyme sensor,
  • the mouthpiece type device according to (9) or (10) above, wherein each of the movable walls included in the plurality of sensor units is made to sequentially perform increase/decrease control to increase and decrease the volume of the accommodation chamber.
  • the sensor module includes a plurality of sensor units including the flow path, the storage chamber, the movable wall, and the enzyme sensor, For each sensor unit group including two or more of the plurality of sensor units, the two or more movable walls included in the sensor unit group sequentially perform measurement operations that simultaneously perform increase/decrease control.
  • the mouthpiece type device according to any one of (9) to (13), wherein the sensor module is configured to be removably attached to the mouthpiece.
  • a system comprising: an external device that receives a signal transmitted from the mouthpiece-type device and starts driving a predetermined function using the received signal as a trigger.
  • Power supply 31 ... Transmitter, 32...Vacuum region, 33...Flow path side region, 34...Sensor unit group, 35...Data average calculation circuit, 100...System, 101...Mouthpiece type device, 102...GVS device, 103...Communication section, 104...Current application section , 105, 106, 107... electrode

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Abstract

L'invention concerne un module capteur avec lequel il est possible de mesurer, à une sensibilité élevée, la concentration d'une enzyme dans un liquide soumis à une détection. La présente invention comprend : un trajet d'écoulement dans lequel l'une de ses extrémités ouvertes s'ouvre vers l'extérieur ; une chambre de stockage qui acquiert de la salive (liquide à détecter) depuis un orifice d'embout buccal (extérieur) à travers le trajet d'écoulement et qui stocke la salive ; une paroi mobile qui forme la surface supérieure (surface de paroi) de la chambre de stockage et qui est capable de se déformer dans un sens dans lequel la capacité de la chambre de stockage varie ; et un capteur d'enzyme qui est disposé sur le côté d'une surface inférieure (côté d'une surface latérale), qui fait face à la paroi mobile, de la chambre de stockage, et qui mesure la concentration en amylase (enzyme) de la salive (liquide) stockée dans la chambre de stockage.
PCT/JP2023/005759 2022-03-23 2023-02-17 Module capteur, dispositif de type embout buccal, et système WO2023181741A1 (fr)

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JP2022046191 2022-03-23
JP2022-046191 2022-03-23

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008521514A (ja) * 2004-11-30 2008-06-26 アライン テクノロジー， インコーポレイテッド 口内薬物送達のためのシステムおよび方法
JP3212682U (ja) * 2017-06-22 2017-09-28 味の素株式会社 体液受入れ構造体およびそれを有する体液分析装置
WO2018066227A1 (fr) * 2016-10-06 2018-04-12 ソニーセミコンダクタソリューションズ株式会社 Capteur d'enzyme et dispositif électronique
EP3318216A1 (fr) * 2016-11-04 2018-05-09 Jinkyun Lee Appareil vestimentaire s'attachant à une dent et dispositif de détection se fixant à une dent
WO2020179277A1 (fr) * 2019-03-05 2020-09-10 セイコーインスツル株式会社 Dispositif de surveillance d'organisme intrabuccal

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008521514A (ja) * 2004-11-30 2008-06-26 アライン テクノロジー， インコーポレイテッド 口内薬物送達のためのシステムおよび方法
WO2018066227A1 (fr) * 2016-10-06 2018-04-12 ソニーセミコンダクタソリューションズ株式会社 Capteur d'enzyme et dispositif électronique
JP6894915B2 (ja) * 2016-10-06 2021-06-30 ソニーセミコンダクタソリューションズ株式会社 酵素センサ、および電子機器
EP3318216A1 (fr) * 2016-11-04 2018-05-09 Jinkyun Lee Appareil vestimentaire s'attachant à une dent et dispositif de détection se fixant à une dent
JP3212682U (ja) * 2017-06-22 2017-09-28 味の素株式会社 体液受入れ構造体およびそれを有する体液分析装置
WO2020179277A1 (fr) * 2019-03-05 2020-09-10 セイコーインスツル株式会社 Dispositif de surveillance d'organisme intrabuccal

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