Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
  • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
  • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/04—Dispersions; Emulsions
  • A61K8/06—Emulsions
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/04—Dispersions; Emulsions
  • A61K8/06—Emulsions
  • A61K8/062—Oil-in-water emulsions
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
  • A61K8/04—Dispersions; Emulsions
  • A61K8/06—Emulsions
  • A61K8/064—Water-in-oil emulsions, e.g. Water-in-silicone emulsions
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/31—Hydrocarbons
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
  • A61K8/345—Alcohols containing more than one hydroxy group
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
  • A61K8/89—Polysiloxanes
  • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
  • A61K8/89—Polysiloxanes
  • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
  • A61K8/894—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
  • A61K8/89—Polysiloxanes
  • A61K8/896—Polysiloxanes containing atoms other than silicon, carbon, oxygen and hydrogen, e.g. dimethicone copolyol phosphate
  • A61K8/898—Polysiloxanes containing atoms other than silicon, carbon, oxygen and hydrogen, e.g. dimethicone copolyol phosphate containing nitrogen, e.g. amodimethicone, trimethyl silyl amodimethicone or dimethicone propyl PG-betaine
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q19/00—Preparations for care of the skin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
  • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
  • A61K2800/59—Mixtures
  • A61K2800/591—Mixtures of compounds not provided for by any of the codes A61K2800/592 - A61K2800/596

Definitions

• the present invention relates to an oil-in-water emulsified cosmetic.
• Patent Document 1 An oil-in-water emulsion composition containing a polyoxyalkylene-modified silicone and having silicone nanodisks formed therein has been proposed (Patent Document 1).
• Such a composition has good emulsification stability, and can contain an amount of oil that cannot be contained in a conventional solubilization process, thereby suppressing stickiness. Users are demanding that such a composition have a better feeling during use, and there is room for further improvement in the feeling during use.
• cyclic carboxamide derivatives tend to be sticky when used in cosmetics.
• the present inventors have surprisingly found that using an oil-in-water cosmetic containing a combination of a polyoxyalkylene-modified silicone and a specific cyclic carboxamide derivative can achieve excellent feeling during use.
• the present invention is based on these findings.
• a cyclic carboxamide derivative represented by formula (1) or a salt thereof (In the formula, R 1 is a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom, X is —CH 2 — or —N(R 2 )—, wherein R 2 is a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom, and n is an integer from 1 to 3), (B) polyoxyalkylene-modified silicone, An oil-in-water emulsified cosmetic comprising (C) oil and (D) water.
• R 1 is a hydroxyalkyl group having 1 to 3 carbon atoms
• component (B) has a linear silicone skeleton.
• an oil-in-water emulsified cosmetic with an excellent feeling of use.
• it provides freshness during application, suppresses stickiness after application, and further imparts a moist feeling to the skin.
• the present invention provides an oil-in-water emulsified cosmetic (hereinafter referred to as a , sometimes referred to as cosmetics).
• the cosmetic according to the present invention is a silicone nanodisc-containing cosmetic. It is believed that silicone nanodisks that do not contain an internal phase and are formed by optimizing the nanodisk precursor vesicles maintain emulsification stability by adsorbing onto the oil droplet surface.
• the cosmetic according to the present invention is a cyclic carboxamide derivative represented by formula (1) or a salt thereof (hereinafter sometimes referred to as component (A). The same applies to other components). There is.).
• component (A) Cyclic carboxamide derivative or salt thereof
• R 1 is a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom
• X is —CH 2 — or —N(R 2 )—
• R 2 is a hydrocarbon group having 1 to 6 carbon atoms which may be substituted with a hydroxyl group, or a hydrogen atom
• n is an integer of 1-3.
• the above hydrocarbon group is not particularly limited, and may be, for example, an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, a cycloalkylalkyl group, a haloalkyl group, an alkoxyalkyl group, or an alkoxycarbonylalkyl group, preferably is an alkyl group.
• R 1 is a hydroxyalkyl group having 1 to 3 carbon atoms
• X is —CH 2 — or —NH—
• n is 1.
• Specific examples of the cyclic carboxamide derivative represented by formula (1) include the following.
• Component (A) is most preferably 1-(2-hydroxyethyl)-2-imidazolidinone.
• the (A) component may be a salt of the cyclic carboxamide derivative represented by formula (1).
• the type of salt is not particularly limited as long as it is a pharmacologically acceptable salt, and may be an inorganic salt or an organic salt.
• inorganic salts include hydrochlorides, sulfates, phosphates, hydrobromides, sodium salts, potassium salts, magnesium salts, calcium salts, magnesium salts, ammonium salts and the like.
• organic salts include acetates, lactates, maleates, fumarates, tartrates, methanesulfonates, p-toluenesulfonates, triethanolamine salts, amino acid salts and the like.
• component (A) component can be blended one or two or more.
• the blending amount of component (A) is preferably 0.05 to 7% by mass, more preferably 0.3 to 4% by mass, and still more preferably 0.5 to 3%, based on the total amount of the cosmetic. 0.5 mass %.
• the cosmetic according to the present invention comprises (B) a polyoxyalkylene-modified silicone.
• Component (B) has a linear or branched polysiloxane as a main skeleton and polyoxyalkylene groups in side chains.
• component (B) has a linear silicone skeleton.
• the polyoxyalkylene group includes a polyoxyethylene group, a polyoxypropylene group, a polyoxybutylene group, a polyoxyethylene/polyoxypropylene group, a polyoxyethylene/polyoxybutylene group and the like, preferably a polyoxyethylene group. is.
• the average degree of polymerization of the monomer units in the polyoxyalkylene group is preferably 5 to 100 or less, more preferably 5 to 50, still more preferably 10 to 15.
• substituents on the polysiloxane skeleton include hydrogen, alkyl groups having 1 to 6 carbon atoms, and aryl groups having 6 to 9 carbon atoms, preferably methyl groups.
• the average degree of polymerization of the monomer units in the polysiloxane skeleton is preferably 3-550.
• the HLB value of component (B) calculated by the Griffin method is preferably less than 10, more preferably 3 or more and less than 10.
• a preferred form of component (B) is one in which a portion of the methyl groups of dimethicone is substituted with polyethylene glycol.
• PEG-10 dimethicone examples thereof include PEG-10 dimethicone, PEG-12 dimethicone, etc., preferably PEG-12 dimethicone. is.
• Commercially available products of PEG-12 dimethicone include DOWSIL ES-5373 (manufactured by Dow Toray), SH3772M, SH3773M, SH3775M (all manufactured by Dow Corning Silicone), IM-22 (manufactured by Wacker Chemical), and the like. .
• the component (B) can be blended either alone or in combination of two or more.
• the blending amount of component (B) is preferably 0.1 to 7% by mass, more preferably 1 to 4% by mass, based on the total amount of the cosmetic.
• component (C) Oil The cosmetic according to the present invention comprises (C) oil.
• component (C) include hydrocarbon oils, silicone oils (excluding component (B)), ester oils, higher fatty acids, higher alcohols, liquid oils, solid oils, semi-solid oils, etc., preferably carbonized oils. Selected from the group consisting of hydrogen oils, silicone oils, and ester oils.
• hydrocarbon oils examples include isododecane, isohexadecane, isoparaffin, mineral oil (liquid paraffin), ozokerite, squalane, pristane, paraffin, ceresin, squalene, petrolatum, microcrystalline wax, and hydrogenated polydecene.
• silicone oils include linear polysiloxanes (e.g., dimethicone, diphenylsiloxyphenyl trimethicone, diphenylpolysiloxane, etc.), cyclic polysiloxanes (e.g., octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, siloxane, etc.), silicone resins forming a three-dimensional network structure, silicone rubbers, various modified polysiloxanes (amino-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane, etc.), acrylic silicones, etc., preferably is a linear polysiloxane.
• linear polysiloxanes e.g., dimethicone, diphenylsiloxyphenyl trimethicone, diphenylpolysilox
• ester oils include octyl octanoate, nonyl nonanoate, cetyl octanoate, isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, ethylhexyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, and oleic acid.
• higher fatty acids examples include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylenic acid, toric acid, isostearic acid, linoleic acid, linoleic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid ( DHA) and the like.
• Higher alcohols include, for example, straight-chain alcohols (eg, lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, etc.), branched-chain alcohols (eg, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, octyldodecanol, etc.).
• straight-chain alcohols eg, lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, etc.
• branched-chain alcohols eg, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, octyldodecanol, etc.
• Liquid oils include, for example, avocado oil, camellia oil, macadamia nut oil, corn oil, olive oil, rapeseed oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, linseed oil, safflower oil, cottonseed oil, and eno oil. , soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, sinagiri oil, Japanese pear oil, jojoba oil, germ oil, triglycerin and the like.
• solid oils include cacao butter, coconut oil, hydrogenated coconut oil, palm oil, palm kernel oil, hydrogenated palm oil, Japanese wax kernel oil, hydrogenated oil, Japanese wax, and hydrogenated castor oil.
• Semi-solid oils include, for example, shea butter, partially hydrogenated coconut oil, partially hydrogenated jojoba oil, and the like.
• component (C) component can be blended one or two or more.
• the blending amount of component (C) is preferably 0.5 to 30% by mass, more preferably 1 to 15% by mass, based on the total amount of the cosmetic.
• the cosmetic according to the present invention contains (D) water.
• water water used in cosmetics, quasi-drugs, etc. can be used, and for example, purified water, ion-exchanged water, tap water, etc. can be used.
• the amount of water to be blended is preferably 20-95% by mass, more preferably 60-90% by mass, based on the total amount of the cosmetic composition according to the present invention.
• (E) a component selected from the group consisting of ethyl alcohol and dipropylene glycol
• the cosmetic according to the present invention further contains a component selected from the group consisting of (E) ethyl alcohol (ethanol) and dipropylene glycol. can be done.
• Component (E) may be either ethyl alcohol or propylene glycol, or both, but preferably contains both ethyl alcohol and propylene glycol.
• the blending amount of component (E) is preferably 1 to 20% by mass, more preferably 3 to 16% by mass, relative to the total amount of the cosmetic.
• the cosmetic according to the present invention may further contain (F) an ionic surfactant.
• Stability is improved further by containing a component.
• Component (F) is not particularly limited as long as it is different from component (B) and is an ionic surfactant.
• Component (F) is preferably an anionic surfactant, more preferably a sulfonate type anionic surfactant. Sulfosuccinic acid ester salts, acylmethyl taurate salts, acyl taurate salts and the like can be mentioned.
• Component (F) is more preferably N-acylmethyltaurate, and particularly preferably sodium stearoylmethyltaurate.
• component (F) component can be blended one or two or more.
• the blending amount of component (F) is preferably 0.001 to 0.5% by mass, more preferably 0.005 to 0.1% by mass, based on the total amount of the cosmetic.
• the cosmetic according to the present invention may further contain (G) a thickener.
• components (G) include gum arabic, carrageenan, karaya gum, tragacanth gum, carob gum, quince seed (quince), casein, dextrin, gelatin, sodium pectate, sodium araginate, methyl cellulose, ethyl cellulose, CMC, hydroxyethyl cellulose, hydroxy Propyl cellulose, PVA, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer (carbomer), (dimethylacrylamide/acryloyldimethyltaurate Na) crosspolymer, (acryloyldimethyltaurate ammonium/VP) copolymer, (acryloyldimethyltaurate ammonium methacrylic acid) Beheneth-25) Crosspolymer, (sodium acrylate/sodium acryloyldimethyltaurate) copolymer, locust
• component (G) component can be blended one or two or more.
• the blending amount of component (G) is preferably 0.05 to 3% by mass, more preferably 0.2 to 1% by mass, based on the total amount of the cosmetic.
• the cosmetics according to the present invention can contain optional ingredients that are usually used in cosmetics and pharmaceuticals.
• optional components include the following, and one or more of them can be blended as long as the effects of the present invention are achieved.
• moisturizing agents examples include polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol (BG), erythritol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronin acid, atelocollagen, cholesteryl- 12-hydroxystearate, sodium lactate, bile salts, dl-pyrrolidone carboxylate, short-chain soluble collagen, rose rose extract, yarrow extract, melilot extract and the like.
• BG 1,3-butylene glycol
• sequestering agents include 1-hydroxyethane-1,1-diphosphonic acid, tetrasodium 1-hydroxyethane-1,1-diphosphonic acid, disodium edetate (EDTA-2Na), and trisodium edetate.
• EDTA-2Na disodium edetate
• trisodium edetate tetrasodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, succinic acid, edetic acid, trisodium ethylenediaminehydroxyethyl triacetate, and the like.
• neutralizing agents examples include 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-1,3-propanediol, potassium hydroxide, sodium hydroxide, triethanolamine, sodium carbonate, and the like. are mentioned.
• pH adjusters include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate.
• antioxidants include dibutylhydroxytoluene, butylhydroxyanisole, sodium pyrosulfite, and gallic acid esters.
• antiseptics include paraoxybenzoic acid esters such as methylparaben, ethylparaben, and butylparaben, benzoic acid, salicylic acid, sorbic acid, parachlorometacresol, hexachlorophene, benzalkonium chloride, chlorhexidine chloride, and trichlorocarbanilide. , a photosensitive element, phenoxyethanol, and the like.
• drugs include ascorbic acid (vitamin C), tranexamic acid, kojic acid, ellagic acid, arbutin, alkoxysalicylic acid, glycyrrhizic acid, tocopherol, retinol, and salts or derivatives thereof (e.g., sodium L-ascorbate, L -ascorbic acid ester magnesium salt, L-ascorbic acid glucoside, 2-O-ethyl-L-ascorbic acid, 3-O-ethyl-L-ascorbic acid, 4-methoxysalicylic acid sodium salt, 4-methoxysalicylic acid potassium salt, glycyrrhizin dipotassium acid, stearyl glycyrrhizinate, tocopherol acetate, retinol acetate, retinol palmitate, etc.), nicotinic acid or its derivatives (e.g.
• nicotinamide caffeine, tannins, verapamil and its derivatives, licorice extract, glabridin, fire Hot water extract of thorn fruit, various crude drugs, hydrolyzed silk, hydrolyzed conchiolin, tea extract, tormentilla root extract, Angelica keiskei leaf/stem extract, aloe vera leaf extract, cherry leaf extract, angelica root extract, shiikuwasha pericarp extract, iris root extract, thorny rhinoceros / hijirimen / honey kelp / blue laver / wakame seaweed extract, cattail extract, hikiokoshi leaf / stem extract, camellia seed extract, honey kelp / wakame extract, honeysuckle root extract, Dutch mustard leaf / stem extract, cassia bark extract, rose Marie leaf oil, lavender oil, glutamic acid, trimethylglycine, chlorphenesin, menthoxypropanediol and the like.
• UV absorbers powder ingredients, fragrances, etc. can be added as appropriate.
• the method for producing the cosmetic according to the present invention is not particularly limited, it can be produced, for example, by the following method.
• An aqueous phase and (B) polyoxyethylene-modified silicone are mixed to form vesicles, which are precursors of nanodiscs.
• the aqueous phase is not particularly limited as long as it is a formulation containing water and optionally (component (E) when included) as a main medium, and in addition to water or an aqueous solvent, Ingredients usually used in cosmetics can be blended in amounts within a range that does not impair the stability of the Nanodiscs.
• the vesicles which are the precursors of the Nanodiscs
• (C) oil By adding (C) oil to the aqueous phase containing the vesicles, which are the precursors of the Nanodiscs, and stirring, the vesicles, which are the precursors of the Nanodiscs, are transferred to the Nanodiscs at the oil-water interface, adsorbed, and stabilized. A highly effective cosmetic is formed.
• Other components may be blended in advance in the aqueous phase before vesicle formation, or may be blended after vesicle formation.
• Cosmetics according to the present invention include, for example, skin care cosmetics (e.g. lotions, milky lotions, creams, serums, packs, masks, etc.), makeup cosmetics (e.g., foundations, makeup bases, etc.), skin cleansers (e.g. , face wash, makeup remover, etc.), sunscreen cosmetics, ointments, and the like.
• skin care cosmetics e.g. lotions, milky lotions, creams, serums, packs, masks, etc.
• makeup cosmetics e.g., foundations, makeup bases, etc.
• skin cleansers e.g. , face wash, makeup remover, etc.
• sunscreen cosmetics ointments, and the like.
• Examples 1 to 12 and Comparative Examples 1 to 3 The formulations shown in Tables 1 and 2 were used to prepare cosmetics of Examples 1-12 and Comparative Examples 1-3. Numerical values in the table indicate % by mass. (*1) DOWSIL ES-5373 (manufactured by Dow Toray)

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• 2022
  • 2022-11-16 CN CN202280072901.4A patent/CN118284399A/zh active Pending
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