WO2023068282A1 - Aliment ou boisson, additif alimentaire, complément, produit cosmétique, anticorps, médicament et procédé de fabrication associé - Google Patents
Aliment ou boisson, additif alimentaire, complément, produit cosmétique, anticorps, médicament et procédé de fabrication associé Download PDFInfo
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- WO2023068282A1 WO2023068282A1 PCT/JP2022/038816 JP2022038816W WO2023068282A1 WO 2023068282 A1 WO2023068282 A1 WO 2023068282A1 JP 2022038816 W JP2022038816 W JP 2022038816W WO 2023068282 A1 WO2023068282 A1 WO 2023068282A1
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- Prior art keywords
- antibody
- food
- supplement
- extract
- drink
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Links
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
- A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/02—Preparations containing skin colorants, e.g. pigments
- A61Q1/10—Preparations containing skin colorants, e.g. pigments for eyes, e.g. eyeliner, mascara
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Definitions
- the present invention relates to food and drink, food additives, supplements, cosmetics, antibodies, pharmaceuticals, and methods for producing the same.
- the new coronavirus is raging and has become a pandemic all over the world, but from the past, pandemics caused by viruses such as influenza, SARS, and MERS sometimes strike.
- a technique disclosed in Patent Literature 1 has been developed.
- the present invention has been made in view of such circumstances, and food and drink, food additives, supplements, cosmetics, antibodies, medicines, and their
- the object is to provide a manufacturing method.
- the food or drink according to the present invention is characterized by containing an antibody.
- the food and drink of the present invention further contain a natural raw material having a bactericidal effect.
- the natural raw material preferably contains a plant extract.
- the plant extract preferably contains a grapefruit extract or a tea extract.
- the grapefruit extract preferably contains a grapefruit seed extract.
- the tea extract preferably contains tea catechins.
- the food and drink of the present invention are preferably sterilized by heating in a low temperature atmosphere of 50°C to 65°C.
- the sterilization time is preferably within 60 minutes.
- the food and drink of the present invention are preferably pressurized and sterilized in a high pressure atmosphere of 500 to 1500 atm.
- the food and drink of the present invention are preferably sterilized using radiation.
- the food or drink of the present invention is preferably spray, jelly, candy, capsule, tablet, round, powder, granule, fine grain, troche, liquid or gel.
- the spray form is preferably in the form of an intraoral spray.
- the capsule is preferably in the form of an enteric capsule. At least one of dairy products, fermented foods, and drinks is preferred.
- the antibody is preferably an antibody produced outside the human body.
- Said antibody preferably comprises an IgY antibody and/or an IgG antibody.
- the food additive according to the present invention is characterized by containing an antibody.
- an antibody-containing food additive can be provided.
- food additives can quickly respond to pandemics caused by viruses using antibodies without the need for clinical trials (trials) that are required for vaccines, pharmaceuticals, and the like.
- the food additive of the present invention further contains a natural raw material having a bactericidal effect.
- the natural raw material preferably contains a plant extract.
- the plant extract preferably contains a grapefruit extract or a tea extract.
- the grapefruit extract preferably contains a grapefruit seed extract.
- the tea extract preferably contains tea catechins.
- the food additive is preferably sterilized by heating in a low temperature atmosphere of 50°C to 65°C.
- the sterilization time is preferably within 60 minutes.
- the food additive of the present invention is preferably pressurized and sterilized in a high pressure atmosphere of 500 to 1500 atm.
- the food additive of the present invention is preferably sterilized using radiation.
- the food additive of the present invention is preferably in the form of spray, jelly, candy, capsule, tablet, round, powder, granule, fine grain, troche, liquid or gel.
- the spray form is preferably in the form of an intraoral spray.
- the capsule is preferably in the form of an enteric capsule.
- the antibody is preferably an antibody produced outside the human body. Said antibody preferably comprises an IgY antibody and/or an IgG antibody.
- the food additive of the present invention is preferably at least one of dairy products, fermented foods, and drinks.
- a supplement according to the present invention is characterized by containing an antibody.
- a supplement containing an antibody can be provided.
- supplements can quickly respond to pandemics caused by viruses using antibodies without the need for clinical trials (trials) that are required for vaccines, pharmaceuticals, and the like.
- the supplement of the present invention preferably further contains natural raw materials having a bactericidal effect.
- the natural raw material preferably contains a plant extract.
- the plant extract preferably contains a grapefruit extract or a tea extract.
- the grapefruit extract preferably contains a grapefruit seed extract.
- the tea extract preferably contains tea catechins.
- the supplement of the present invention is preferably sterilized by heating in a low temperature atmosphere of 50°C to 65°C.
- the sterilization time is preferably within 60 minutes.
- the supplement of the present invention is preferably pressurized and sterilized under a high pressure atmosphere of 500 to 1500 atm.
- the supplement of the present invention is preferably sterilized using radiation.
- the supplement of the present invention is preferably in the form of spray, jelly, candy, capsule, tablet, round, powder, granule, fine grain, troche, liquid or gel.
- the spray form is preferably in the form of an intraoral spray.
- the capsule is preferably in the form of an enteric capsule.
- the antibody is preferably an antibody produced outside the human body. Said antibody preferably comprises an IgY antibody and/or an IgG antibody.
- the supplement is preferably at least one of dairy products, fermented foods, and drinks.
- the cosmetic according to the present invention is characterized by containing an antibody.
- cosmetics containing antibodies can be provided.
- cosmetics can quickly respond to pandemics caused by viruses using antibodies without the need for clinical trials (trials) that are required for vaccines, pharmaceuticals, and the like.
- the cosmetic of the present invention further contain a natural raw material having a bactericidal effect.
- the natural raw material preferably contains a plant extract.
- the plant extract preferably contains a grapefruit extract or a tea extract.
- the grapefruit extract preferably contains a grapefruit seed extract.
- the tea extract preferably contains tea catechins.
- the cosmetic of the present invention is preferably sterilized by heating in a low temperature atmosphere of 50°C to 65°C.
- the sterilization time is preferably within 60 minutes.
- the cosmetics of the present invention are preferably pressurized and sterilized in a high-pressure atmosphere of 500 to 1500 atm.
- the cosmetics of the present invention are preferably sterilized using radiation.
- the cosmetic of the present invention preferably further contains a negatively charged substance.
- the cosmetic product of the present invention is preferably in at least one of spray, cream, liquid, gel, paste, emulsion, and mousse.
- the spray form preferably includes a skin spray.
- the cream preferably includes at least one of skin cream, lip cream, nasal cavity cream, and eye cream.
- the antibody is preferably an antibody produced outside the human body. Said antibody preferably comprises an IgY antibody and/or an IgG antibody.
- the antibody according to the present invention is characterized by being produced outside the human body, and preferably contains an IgY antibody and/or an IgG antibody.
- the pharmaceutical according to the present invention is characterized by containing an antibody.
- the medicament of the present invention further contains a natural raw material having a bactericidal effect.
- the natural raw material preferably contains a plant extract.
- the plant extract preferably contains a grapefruit extract or a tea extract.
- the grapefruit extract preferably contains a grapefruit seed extract.
- the tea extract preferably contains tea catechins.
- the medicament of the present invention is preferably sterilized by heating in a low temperature atmosphere of 50°C to 65°C.
- the sterilization time is preferably within 60 minutes.
- the pharmaceutical of the present invention is preferably pressurized and sterilized in a high-pressure atmosphere of 500 to 1500 atm.
- the medicament of the present invention is preferably sterilized using radiation.
- the medicament of the present invention is preferably in the form of spray, jelly, candy, capsule, tablet, round, powder, granule, fine grain, troche, liquid, or gel.
- the spray form is preferably in the form of an intraoral spray.
- the capsule is preferably in the form of an enteric capsule.
- the pharmaceutical of the present invention is preferably at least one of dairy products, fermented foods, and drinks.
- the antibody is preferably produced outside the human body.
- Said antibody preferably comprises an IgY antibody and/or an IgG antibody.
- the medicament of the present invention is preferably used to prevent and/or treat infectious diseases in subjects.
- the infectious disease preferably includes one or more infectious diseases selected from the group consisting of coronavirus, influenza, SARS, and MARS.
- the subject is preferably a mammal, and the mammal is preferably a human.
- the production method according to the present invention provides antibodies, antibody-blended foods and drinks, food additives, supplements, cosmetics, and at least one of pharmaceuticals in a low-temperature atmosphere of 50°C to 65°C. It is characterized by being manufactured by heating and sterilizing.
- the sterilization time is preferably within 60 minutes.
- the sterilization treatment is carried out under a high pressure atmosphere of 500 to 1500 atm.
- antibodies can be used to promptly respond to viral pandemics.
- FIG. 1 is a diagram showing an antibody 1, a food or drink 10, a food additive 20, a supplement 30, a medicine 40, and a cosmetic 50 according to an embodiment of the present invention.
- the antibody 1 is preferably an antibody 1 produced outside the human body, and the antibody 1 is more specifically an IgY antibody, which is an immunoglobulin derived from chicken eggs, and/or an IgG antibody. More specifically, an antibody derived from a mouse. It preferably includes an IgG antibody that is a globulin. IgY and IgG antibodies preferably include monoclonal or polyclonal antibodies. An IgY antibody can be produced by culturing and purifying an extract extracted from chicken eggs, and an IgG antibody can be produced by culturing and purifying an extract extracted from a mouse.
- Antibody 1 produced outside the human body does not need to immunize the human body with an antigen, so it is said that there is no risk of allergic reaction.
- IgY antibodies and IgG antibodies are capable of neutralizing antigens, more specifically neutralizing viral bodies, viral proteins, viral genes, and ACE2 receptor proteins (spike proteins).
- the antibody (for example, immunoglobulin) 1 is a glycoprotein molecule produced by B cells among lymphocytes, and has the function of recognizing and binding to a molecule (antigen) such as a specific protein.
- Antibody 1 is mainly present in blood and body fluids, and recognizes and binds to, for example, bacteria, viruses, and cells infected with microorganisms that have invaded the body as antigens.
- phagocytic cells such as leukocytes and microphages recognize and phagocytize the complex of the antigen and Antibody 1 and work to remove it from the body, and immune cells such as lymphocytes bind and become immune. It is something that provokes a reaction.
- the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 according to the embodiment of the present invention are characterized by containing the antibody 1 described above.
- the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 of the present invention preferably further contain one or more natural raw materials 2 that have bactericidal and antioxidant effects and do not cause protein denaturation of the antibody 1.
- the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 are subjected to heat treatment for the purpose of sterilization, for example, and by controlling the pH to 4 or less, the protein is denatured and the effect of the antibody 1 is reduced.
- the antibody can be obtained without heat treatment and without controlling the pH to 4 or less. 1 can suppress protein denaturation.
- the natural raw material 2 preferably contains a plant extract, and the plant extract preferably contains a grapefruit extract or a tea extract. Furthermore, the grapefruit extract preferably contains a grapefruit seed extract, and the tea extract preferably contains tea catechins. Grapefruit seed extracts extracted from grapefruit seeds and tea catechins extracted from tea leaves have excellent bactericidal effects.
- the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 of the present invention are preferably heated and sterilized in a low-temperature atmosphere of 50°C to 65°C (the food and drink 10, the food additive 20,
- the supplement 30 and the medicine 40 are preferably manufactured by a manufacturing method in which they are heated and sterilized in a low temperature atmosphere of 50° C. to 65° C.).
- the sterilization time is preferably within 60 minutes. That is, when antibody 1 is treated in a high-temperature atmosphere for a long time, protein denaturation may occur, but sterilization is performed in a low-temperature atmosphere of 50 to 65 ° C., and the sterilization time is within 60 minutes. This can suppress the occurrence of protein denaturation.
- the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 of the present invention are preferably pressurized and sterilized in a high pressure atmosphere of 500 to 1500 atm
- the food and drink 10, the food additive 20 , the supplement 30 and the medicine 40 are preferably manufactured by a manufacturing method in which they are pressurized and sterilized in a high-pressure atmosphere of 500 to 1500 atm). That is, by performing the sterilization treatment in a high-pressure atmosphere of 500 to 1500 atm, the treatment can be performed in a room temperature atmosphere, and protein denaturation can be suppressed.
- the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 of the present invention are preferably sterilized using radiation (manufacturing of the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 is preferably carried out by a manufacturing method in which radiation is used to sterilize and manufacture). That is, by performing a sterilization treatment using radiation, it is possible to realize the treatment in a room temperature atmosphere and suppress the occurrence of protein denaturation.
- Blending of one or more natural raw materials 2 described above as a method of suppressing protein denaturation in the food and drink 10, food additive 20, supplement 30, and medicine 40 of the present invention, and sterilization in a low temperature atmosphere of 50 to 65 °C. , sterilization treatment under a high pressure atmosphere of 500 to 1500 atm, and sterilization treatment using radiation may be performed alone, may be appropriately combined with two or more, or may be appropriately combined with three or more. Well, you can do all four.
- the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 of the present invention are spray-like, jelly-like, candy-like, capsule-like, tablet-like, round-like, powder-like, granule-like, fine-grain-like, troche. It is preferably in the form of liquid, liquid or gel. That is, by providing the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 in such a form, they can be used for various purposes.
- the spray form can be in the form of an oral spray
- the capsule form can be in the form of an enteric capsule
- the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 can be at least one of dairy products, fermented foods, and drinks.
- Dairy products can be, for example, lactic acid beverages, yogurt, etc.
- Fermented foods can be natto, kimchi, etc.
- drinks can be juices, health drinks, sports drinks, and the like.
- medicament 40 can be used to prevent and/or treat infections in a subject.
- Infectious diseases can include one or more infectious diseases selected from the group consisting of coronavirus, influenza, SARS, and MARS.
- the subject can be a mammal, and the mammal can be a human.
- the antibody 1 By ingesting the food and drink 10, the food additive 20, the supplement 30, and the medicine 40, the antibody 1 can be used to promptly respond to a virus pandemic.
- the type of food and drink 10 described above is not particularly limited, and food and drink 10 includes beverages and foods.
- the food and drink 10 include beverages, noodles, confectionery, meat or livestock processed foods, grain processed foods, vegetable processed foods, fruit processed foods, dairy products, oil and fat processed foods, seasonings and the like.
- the food additive 20 is a substance added for the purpose of processing or preserving the food and drink 10, and has technical purposes such as reducing oxidation, coloring the product, enhancing its taste, and the like.
- added to food for Food additives 20 include coloring agents (including whitening agents), preservatives, antioxidants, acidulants/acidity correctors, and texture imparting agents (stabilizers, emulsifiers, thickeners, gelling agents), and the like. include.
- the food additive 20 may contain other ingredients for the food additive 20 as desired. Other ingredients include colorants, preservatives, sweeteners, thickeners, stabilizers, gelling agents, antioxidants, emulsifiers, flavors and the like.
- the supplement 30 refers to a composition classified as a food for the purpose of supplementing nutrition and maintaining health, and includes health food, functional food, nutritional supplement, and food for specified health uses.
- the supplement 30 includes, for example, concentrated vitamins, minerals, and other ingredients in tablet, capsule, or powder form.
- the form of the supplement 30 is not particularly limited as long as it can be administered orally, and the supplement 30 may contain other ingredients that can be used as ingredients for supplements.
- Other ingredients include polysaccharides, antioxidants, proteins, salts, and the like.
- the form of the medicine 40 is not particularly limited, and the medicine 40 is used for prevention and/or treatment of target diseases or lesions.
- the medicine 40 may contain additives or pharmaceutically acceptable carriers as needed.
- additives or pharmaceutically acceptable carriers include excipients, disintegrants, binders, lubricants, surfactants, buffers, solubilizers, stabilizers, tonicity agents, suspending agents, Turbiding agents, emulsifiers, solvents, thickeners, mucolytic agents, wetting agents, preservatives and the like.
- a cosmetic product 50 according to an embodiment of the present invention is characterized by containing the antibody 1 described above.
- the type of the cosmetics 50 is not particularly limited, and the cosmetics 50 include lotion, milky lotion, foundation, lipstick, lip balm, cleansing cream, massage cream, mask, hand cream, hand powder, body shampoo, body lotion, body cream, Forms such as bath cosmetics can be included.
- the cosmetic product 50 of the present invention preferably further contains one or more natural raw materials 2 that have a bactericidal effect and an antioxidant effect and do not cause protein denaturation of the antibody 1 .
- the cosmetic 50 is heat-treated for the purpose of sterilization, and by controlling the pH to 4 or less, the protein may be denatured and the effect of the antibody 1 may be reduced.
- the natural raw material 2 preferably contains a plant extract, and the plant extract preferably contains a grapefruit extract or a tea extract. Furthermore, the grapefruit extract preferably contains a grapefruit seed extract, and the tea extract preferably contains tea catechins. Grapefruit seed extracts extracted from grapefruit seeds and tea catechins extracted from tea leaves have excellent bactericidal effects.
- the cosmetic 50 of the present invention is preferably heated and sterilized in a low temperature atmosphere of 50 to 65 ° C. It is preferable to use a manufacturing method that manufactures by The sterilization time is preferably within 60 minutes. That is, when antibody 1 is treated in a high-temperature atmosphere for a long time, protein denaturation may occur, but sterilization is performed in a low-temperature atmosphere of 50 to 65 ° C., and the sterilization time is within 60 minutes. This can suppress the occurrence of protein denaturation.
- the cosmetic 50 of the present invention is preferably pressurized and sterilized in a high-pressure atmosphere of 500 to 1500 atm (the cosmetic 50 is produced by pressurizing and sterilizing in a high-pressure atmosphere of 500 to 1500 atm). It is preferably carried out by a manufacturing method that processes and manufactures). That is, by performing the sterilization treatment in a high-pressure atmosphere of 500 to 1500 atm, the treatment can be performed in a room temperature atmosphere, and protein denaturation can be suppressed.
- the cosmetics 50 of the present invention are preferably sterilized using radiation (the cosmetics 50 are preferably manufactured by a manufacturing method that sterilizes using radiation). That is, by performing a sterilization treatment using radiation, it is possible to realize the treatment in a room temperature atmosphere and suppress the occurrence of protein denaturation.
- the sterilization treatment and the sterilization treatment using radiation may each be performed alone, two or more may be appropriately combined, three or more may be appropriately combined, or all four may be performed.
- the cosmetic 50 of the present invention further contains a negatively charged substance such as ceramics. That is, antigens (viruses) are often negatively charged, and by adding a negatively charged substance to the cosmetics 50, the negatively charged virus is repelled and the virus is prevented from adhering to the skin. can do.
- a negatively charged substance such as ceramics.
- antigens viruses
- Various substances other than ceramics can be used as the negatively charged substance.
- the cosmetic product 50 of the present invention is preferably in at least one of spray, cream, liquid, gel, paste, emulsion, and mousse. That is, by providing the cosmetic product 50 in such a form, it can be used for various purposes.
- the spray type preferably includes a skin spray
- the cream type includes at least one of skin cream, lip cream, nasal cavity cream, and eye area (eyelid, outer corner of the eye, lacrimal bag, etc.) cream. preferably included.
- Antibody 2 Natural raw materials 10: Food and drink 20: Food additives 30: Supplements 40: Medicines 50: Cosmetics
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Birds (AREA)
- Epidemiology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
Abstract
L'invention a pour but de fournir un aliment ou une boisson, un additif alimentaire, un complément, un produit cosmétique, un anticorps, et un médicament avec lequel il est possible de réagir rapidement à une pandémie au moyen d'un anticorps, et de fournir un procédé de fabrication associé. La solution selon l'invention porte sur un anticorps (1), un aliment ou une boisson (10), un additif alimentaire (20), un complément (30), un médicament (40), et un produit cosmétique (50) selon la présente invention, chacun étant additionné d'un anticorps IgY et/ou d'un anticorps IgG produit à l'extérieur d'un corps humain, et chacun étant en outre additionné d'une matière première naturelle (2) ayant un effet stérilisant. La matière première naturelle (2) comprend de préférence un extrait végétal, et l'extrait végétal comprend de préférence un extrait issu de pamplemousse ou un extrait issu de thé.
Priority Applications (2)
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PCT/JP2022/039193 WO2023068343A1 (fr) | 2021-10-21 | 2022-10-20 | Aliment ou boisson, additif alimentaire, complément, produit cosmétique, anticorps, produit pharmaceutique et procédés de production associés |
JP2023554744A JPWO2023068343A1 (fr) | 2021-10-21 | 2022-10-20 |
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JP2021-172752 | 2021-10-21 | ||
JP2021172752 | 2021-10-21 |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001017122A (ja) * | 1999-07-12 | 2001-01-23 | Taiyo Kagaku Co Ltd | 消化器系炎症予防用食品 |
JP2002316943A (ja) * | 2001-04-17 | 2002-10-31 | Pharmafoods Kenkyusho:Kk | 抗ニキビ組成物及びそれを含有するニキビ用化粧料 |
JP2007082469A (ja) * | 2005-09-22 | 2007-04-05 | En Otsuka Pharmaceutical Co Ltd | 口腔ケア用飲食品 |
JP2007185134A (ja) * | 2006-01-12 | 2007-07-26 | Asama Chemical Co Ltd | 容器詰飲料およびそれらの製造方法 |
US20210238261A1 (en) * | 2018-08-17 | 2021-08-05 | Industry Academic Cooperation Foundation, Hallym University | Monoclonal antibody against s protein of mers-coronavirus, and use of same |
WO2021181994A1 (fr) * | 2020-03-10 | 2021-09-16 | デンカ株式会社 | Épitope d'anticorps dirigé contre la protéine structurelle du sras-cov-2, anticorps réagissant avec l'épitope, procédé de détection de sras-cov-2 à l'aide d'anticorps, kit de détection pour anticorps contenant sras-cov-2, procédé de détection d'anticorps anti-sras-cov-2 contenant un polypeptide d'épitope, kit de détection pour un anticorps anti-sras-cov-2 contenant un polypeptide d'épitope, vaccin contre sras-cov-2 contenant un polypeptide d'épitope, et agent thérapeutique pour une infection à sras-cov-2 contenant l'anticorps |
-
2022
- 2022-10-18 WO PCT/JP2022/038816 patent/WO2023068282A1/fr unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001017122A (ja) * | 1999-07-12 | 2001-01-23 | Taiyo Kagaku Co Ltd | 消化器系炎症予防用食品 |
JP2002316943A (ja) * | 2001-04-17 | 2002-10-31 | Pharmafoods Kenkyusho:Kk | 抗ニキビ組成物及びそれを含有するニキビ用化粧料 |
JP2007082469A (ja) * | 2005-09-22 | 2007-04-05 | En Otsuka Pharmaceutical Co Ltd | 口腔ケア用飲食品 |
JP2007185134A (ja) * | 2006-01-12 | 2007-07-26 | Asama Chemical Co Ltd | 容器詰飲料およびそれらの製造方法 |
US20210238261A1 (en) * | 2018-08-17 | 2021-08-05 | Industry Academic Cooperation Foundation, Hallym University | Monoclonal antibody against s protein of mers-coronavirus, and use of same |
WO2021181994A1 (fr) * | 2020-03-10 | 2021-09-16 | デンカ株式会社 | Épitope d'anticorps dirigé contre la protéine structurelle du sras-cov-2, anticorps réagissant avec l'épitope, procédé de détection de sras-cov-2 à l'aide d'anticorps, kit de détection pour anticorps contenant sras-cov-2, procédé de détection d'anticorps anti-sras-cov-2 contenant un polypeptide d'épitope, kit de détection pour un anticorps anti-sras-cov-2 contenant un polypeptide d'épitope, vaccin contre sras-cov-2 contenant un polypeptide d'épitope, et agent thérapeutique pour une infection à sras-cov-2 contenant l'anticorps |
Non-Patent Citations (2)
Title |
---|
GO CAMILLE CELESTE, PANDAV KRUNAL, SANCHEZ-GONZALEZ MARCOS A, FERRER GUSTAVO: "Potential Role of Xylitol Plus Grapefruit Seed Extract Nasal Spray Solution in COVID-19: Case Series", CUREUS, 3 November 2020 (2020-11-03), US , XP093056418, ISSN: 2168-8184, DOI: 10.7759/cureus.11315 * |
OHGITANI ERIKO, SHIN-YA MASAHARU, ICHITANI MASAKI, KOBAYASHI MAKOTO, TAKIHARA TAKANOBU, KAWAMOTO MASAYA, KINUGASA HITOSHI, MAZDA O: "Significant Inactivation of SARS-CoV-2 In Vitro by a Green Tea Catechin, a Catechin-Derivative, and Black Tea Galloylated Theaflavins", MOLECULES, vol. 26, no. 12, pages 3572, XP093059741, DOI: 10.3390/molecules26123572 * |
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