WO2023068282A1 - Food or drink, food additive, supplement, cosmetic, antibody, drug, and manufacturing method therefor - Google Patents

Food or drink, food additive, supplement, cosmetic, antibody, drug, and manufacturing method therefor Download PDF

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Publication number
WO2023068282A1
WO2023068282A1 PCT/JP2022/038816 JP2022038816W WO2023068282A1 WO 2023068282 A1 WO2023068282 A1 WO 2023068282A1 JP 2022038816 W JP2022038816 W JP 2022038816W WO 2023068282 A1 WO2023068282 A1 WO 2023068282A1
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WIPO (PCT)
Prior art keywords
antibody
food
supplement
extract
drink
Prior art date
Application number
PCT/JP2022/038816
Other languages
French (fr)
Japanese (ja)
Inventor
美幸 徳田
Original Assignee
美幸 徳田
後藤 宏彰
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美幸 徳田, 後藤 宏彰 filed Critical 美幸 徳田
Priority to PCT/JP2022/039193 priority Critical patent/WO2023068343A1/en
Priority to JP2023554744A priority patent/JPWO2023068343A1/ja
Publication of WO2023068282A1 publication Critical patent/WO2023068282A1/en

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A61Q1/10—Preparations containing skin colorants, e.g. pigments for eyes, e.g. eyeliner, mascara
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to food and drink, food additives, supplements, cosmetics, antibodies, pharmaceuticals, and methods for producing the same.
  • the new coronavirus is raging and has become a pandemic all over the world, but from the past, pandemics caused by viruses such as influenza, SARS, and MERS sometimes strike.
  • a technique disclosed in Patent Literature 1 has been developed.
  • the present invention has been made in view of such circumstances, and food and drink, food additives, supplements, cosmetics, antibodies, medicines, and their
  • the object is to provide a manufacturing method.
  • the food or drink according to the present invention is characterized by containing an antibody.
  • the food and drink of the present invention further contain a natural raw material having a bactericidal effect.
  • the natural raw material preferably contains a plant extract.
  • the plant extract preferably contains a grapefruit extract or a tea extract.
  • the grapefruit extract preferably contains a grapefruit seed extract.
  • the tea extract preferably contains tea catechins.
  • the food and drink of the present invention are preferably sterilized by heating in a low temperature atmosphere of 50°C to 65°C.
  • the sterilization time is preferably within 60 minutes.
  • the food and drink of the present invention are preferably pressurized and sterilized in a high pressure atmosphere of 500 to 1500 atm.
  • the food and drink of the present invention are preferably sterilized using radiation.
  • the food or drink of the present invention is preferably spray, jelly, candy, capsule, tablet, round, powder, granule, fine grain, troche, liquid or gel.
  • the spray form is preferably in the form of an intraoral spray.
  • the capsule is preferably in the form of an enteric capsule. At least one of dairy products, fermented foods, and drinks is preferred.
  • the antibody is preferably an antibody produced outside the human body.
  • Said antibody preferably comprises an IgY antibody and/or an IgG antibody.
  • the food additive according to the present invention is characterized by containing an antibody.
  • an antibody-containing food additive can be provided.
  • food additives can quickly respond to pandemics caused by viruses using antibodies without the need for clinical trials (trials) that are required for vaccines, pharmaceuticals, and the like.
  • the food additive of the present invention further contains a natural raw material having a bactericidal effect.
  • the natural raw material preferably contains a plant extract.
  • the plant extract preferably contains a grapefruit extract or a tea extract.
  • the grapefruit extract preferably contains a grapefruit seed extract.
  • the tea extract preferably contains tea catechins.
  • the food additive is preferably sterilized by heating in a low temperature atmosphere of 50°C to 65°C.
  • the sterilization time is preferably within 60 minutes.
  • the food additive of the present invention is preferably pressurized and sterilized in a high pressure atmosphere of 500 to 1500 atm.
  • the food additive of the present invention is preferably sterilized using radiation.
  • the food additive of the present invention is preferably in the form of spray, jelly, candy, capsule, tablet, round, powder, granule, fine grain, troche, liquid or gel.
  • the spray form is preferably in the form of an intraoral spray.
  • the capsule is preferably in the form of an enteric capsule.
  • the antibody is preferably an antibody produced outside the human body. Said antibody preferably comprises an IgY antibody and/or an IgG antibody.
  • the food additive of the present invention is preferably at least one of dairy products, fermented foods, and drinks.
  • a supplement according to the present invention is characterized by containing an antibody.
  • a supplement containing an antibody can be provided.
  • supplements can quickly respond to pandemics caused by viruses using antibodies without the need for clinical trials (trials) that are required for vaccines, pharmaceuticals, and the like.
  • the supplement of the present invention preferably further contains natural raw materials having a bactericidal effect.
  • the natural raw material preferably contains a plant extract.
  • the plant extract preferably contains a grapefruit extract or a tea extract.
  • the grapefruit extract preferably contains a grapefruit seed extract.
  • the tea extract preferably contains tea catechins.
  • the supplement of the present invention is preferably sterilized by heating in a low temperature atmosphere of 50°C to 65°C.
  • the sterilization time is preferably within 60 minutes.
  • the supplement of the present invention is preferably pressurized and sterilized under a high pressure atmosphere of 500 to 1500 atm.
  • the supplement of the present invention is preferably sterilized using radiation.
  • the supplement of the present invention is preferably in the form of spray, jelly, candy, capsule, tablet, round, powder, granule, fine grain, troche, liquid or gel.
  • the spray form is preferably in the form of an intraoral spray.
  • the capsule is preferably in the form of an enteric capsule.
  • the antibody is preferably an antibody produced outside the human body. Said antibody preferably comprises an IgY antibody and/or an IgG antibody.
  • the supplement is preferably at least one of dairy products, fermented foods, and drinks.
  • the cosmetic according to the present invention is characterized by containing an antibody.
  • cosmetics containing antibodies can be provided.
  • cosmetics can quickly respond to pandemics caused by viruses using antibodies without the need for clinical trials (trials) that are required for vaccines, pharmaceuticals, and the like.
  • the cosmetic of the present invention further contain a natural raw material having a bactericidal effect.
  • the natural raw material preferably contains a plant extract.
  • the plant extract preferably contains a grapefruit extract or a tea extract.
  • the grapefruit extract preferably contains a grapefruit seed extract.
  • the tea extract preferably contains tea catechins.
  • the cosmetic of the present invention is preferably sterilized by heating in a low temperature atmosphere of 50°C to 65°C.
  • the sterilization time is preferably within 60 minutes.
  • the cosmetics of the present invention are preferably pressurized and sterilized in a high-pressure atmosphere of 500 to 1500 atm.
  • the cosmetics of the present invention are preferably sterilized using radiation.
  • the cosmetic of the present invention preferably further contains a negatively charged substance.
  • the cosmetic product of the present invention is preferably in at least one of spray, cream, liquid, gel, paste, emulsion, and mousse.
  • the spray form preferably includes a skin spray.
  • the cream preferably includes at least one of skin cream, lip cream, nasal cavity cream, and eye cream.
  • the antibody is preferably an antibody produced outside the human body. Said antibody preferably comprises an IgY antibody and/or an IgG antibody.
  • the antibody according to the present invention is characterized by being produced outside the human body, and preferably contains an IgY antibody and/or an IgG antibody.
  • the pharmaceutical according to the present invention is characterized by containing an antibody.
  • the medicament of the present invention further contains a natural raw material having a bactericidal effect.
  • the natural raw material preferably contains a plant extract.
  • the plant extract preferably contains a grapefruit extract or a tea extract.
  • the grapefruit extract preferably contains a grapefruit seed extract.
  • the tea extract preferably contains tea catechins.
  • the medicament of the present invention is preferably sterilized by heating in a low temperature atmosphere of 50°C to 65°C.
  • the sterilization time is preferably within 60 minutes.
  • the pharmaceutical of the present invention is preferably pressurized and sterilized in a high-pressure atmosphere of 500 to 1500 atm.
  • the medicament of the present invention is preferably sterilized using radiation.
  • the medicament of the present invention is preferably in the form of spray, jelly, candy, capsule, tablet, round, powder, granule, fine grain, troche, liquid, or gel.
  • the spray form is preferably in the form of an intraoral spray.
  • the capsule is preferably in the form of an enteric capsule.
  • the pharmaceutical of the present invention is preferably at least one of dairy products, fermented foods, and drinks.
  • the antibody is preferably produced outside the human body.
  • Said antibody preferably comprises an IgY antibody and/or an IgG antibody.
  • the medicament of the present invention is preferably used to prevent and/or treat infectious diseases in subjects.
  • the infectious disease preferably includes one or more infectious diseases selected from the group consisting of coronavirus, influenza, SARS, and MARS.
  • the subject is preferably a mammal, and the mammal is preferably a human.
  • the production method according to the present invention provides antibodies, antibody-blended foods and drinks, food additives, supplements, cosmetics, and at least one of pharmaceuticals in a low-temperature atmosphere of 50°C to 65°C. It is characterized by being manufactured by heating and sterilizing.
  • the sterilization time is preferably within 60 minutes.
  • the sterilization treatment is carried out under a high pressure atmosphere of 500 to 1500 atm.
  • antibodies can be used to promptly respond to viral pandemics.
  • FIG. 1 is a diagram showing an antibody 1, a food or drink 10, a food additive 20, a supplement 30, a medicine 40, and a cosmetic 50 according to an embodiment of the present invention.
  • the antibody 1 is preferably an antibody 1 produced outside the human body, and the antibody 1 is more specifically an IgY antibody, which is an immunoglobulin derived from chicken eggs, and/or an IgG antibody. More specifically, an antibody derived from a mouse. It preferably includes an IgG antibody that is a globulin. IgY and IgG antibodies preferably include monoclonal or polyclonal antibodies. An IgY antibody can be produced by culturing and purifying an extract extracted from chicken eggs, and an IgG antibody can be produced by culturing and purifying an extract extracted from a mouse.
  • Antibody 1 produced outside the human body does not need to immunize the human body with an antigen, so it is said that there is no risk of allergic reaction.
  • IgY antibodies and IgG antibodies are capable of neutralizing antigens, more specifically neutralizing viral bodies, viral proteins, viral genes, and ACE2 receptor proteins (spike proteins).
  • the antibody (for example, immunoglobulin) 1 is a glycoprotein molecule produced by B cells among lymphocytes, and has the function of recognizing and binding to a molecule (antigen) such as a specific protein.
  • Antibody 1 is mainly present in blood and body fluids, and recognizes and binds to, for example, bacteria, viruses, and cells infected with microorganisms that have invaded the body as antigens.
  • phagocytic cells such as leukocytes and microphages recognize and phagocytize the complex of the antigen and Antibody 1 and work to remove it from the body, and immune cells such as lymphocytes bind and become immune. It is something that provokes a reaction.
  • the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 according to the embodiment of the present invention are characterized by containing the antibody 1 described above.
  • the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 of the present invention preferably further contain one or more natural raw materials 2 that have bactericidal and antioxidant effects and do not cause protein denaturation of the antibody 1.
  • the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 are subjected to heat treatment for the purpose of sterilization, for example, and by controlling the pH to 4 or less, the protein is denatured and the effect of the antibody 1 is reduced.
  • the antibody can be obtained without heat treatment and without controlling the pH to 4 or less. 1 can suppress protein denaturation.
  • the natural raw material 2 preferably contains a plant extract, and the plant extract preferably contains a grapefruit extract or a tea extract. Furthermore, the grapefruit extract preferably contains a grapefruit seed extract, and the tea extract preferably contains tea catechins. Grapefruit seed extracts extracted from grapefruit seeds and tea catechins extracted from tea leaves have excellent bactericidal effects.
  • the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 of the present invention are preferably heated and sterilized in a low-temperature atmosphere of 50°C to 65°C (the food and drink 10, the food additive 20,
  • the supplement 30 and the medicine 40 are preferably manufactured by a manufacturing method in which they are heated and sterilized in a low temperature atmosphere of 50° C. to 65° C.).
  • the sterilization time is preferably within 60 minutes. That is, when antibody 1 is treated in a high-temperature atmosphere for a long time, protein denaturation may occur, but sterilization is performed in a low-temperature atmosphere of 50 to 65 ° C., and the sterilization time is within 60 minutes. This can suppress the occurrence of protein denaturation.
  • the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 of the present invention are preferably pressurized and sterilized in a high pressure atmosphere of 500 to 1500 atm
  • the food and drink 10, the food additive 20 , the supplement 30 and the medicine 40 are preferably manufactured by a manufacturing method in which they are pressurized and sterilized in a high-pressure atmosphere of 500 to 1500 atm). That is, by performing the sterilization treatment in a high-pressure atmosphere of 500 to 1500 atm, the treatment can be performed in a room temperature atmosphere, and protein denaturation can be suppressed.
  • the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 of the present invention are preferably sterilized using radiation (manufacturing of the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 is preferably carried out by a manufacturing method in which radiation is used to sterilize and manufacture). That is, by performing a sterilization treatment using radiation, it is possible to realize the treatment in a room temperature atmosphere and suppress the occurrence of protein denaturation.
  • Blending of one or more natural raw materials 2 described above as a method of suppressing protein denaturation in the food and drink 10, food additive 20, supplement 30, and medicine 40 of the present invention, and sterilization in a low temperature atmosphere of 50 to 65 °C. , sterilization treatment under a high pressure atmosphere of 500 to 1500 atm, and sterilization treatment using radiation may be performed alone, may be appropriately combined with two or more, or may be appropriately combined with three or more. Well, you can do all four.
  • the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 of the present invention are spray-like, jelly-like, candy-like, capsule-like, tablet-like, round-like, powder-like, granule-like, fine-grain-like, troche. It is preferably in the form of liquid, liquid or gel. That is, by providing the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 in such a form, they can be used for various purposes.
  • the spray form can be in the form of an oral spray
  • the capsule form can be in the form of an enteric capsule
  • the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 can be at least one of dairy products, fermented foods, and drinks.
  • Dairy products can be, for example, lactic acid beverages, yogurt, etc.
  • Fermented foods can be natto, kimchi, etc.
  • drinks can be juices, health drinks, sports drinks, and the like.
  • medicament 40 can be used to prevent and/or treat infections in a subject.
  • Infectious diseases can include one or more infectious diseases selected from the group consisting of coronavirus, influenza, SARS, and MARS.
  • the subject can be a mammal, and the mammal can be a human.
  • the antibody 1 By ingesting the food and drink 10, the food additive 20, the supplement 30, and the medicine 40, the antibody 1 can be used to promptly respond to a virus pandemic.
  • the type of food and drink 10 described above is not particularly limited, and food and drink 10 includes beverages and foods.
  • the food and drink 10 include beverages, noodles, confectionery, meat or livestock processed foods, grain processed foods, vegetable processed foods, fruit processed foods, dairy products, oil and fat processed foods, seasonings and the like.
  • the food additive 20 is a substance added for the purpose of processing or preserving the food and drink 10, and has technical purposes such as reducing oxidation, coloring the product, enhancing its taste, and the like.
  • added to food for Food additives 20 include coloring agents (including whitening agents), preservatives, antioxidants, acidulants/acidity correctors, and texture imparting agents (stabilizers, emulsifiers, thickeners, gelling agents), and the like. include.
  • the food additive 20 may contain other ingredients for the food additive 20 as desired. Other ingredients include colorants, preservatives, sweeteners, thickeners, stabilizers, gelling agents, antioxidants, emulsifiers, flavors and the like.
  • the supplement 30 refers to a composition classified as a food for the purpose of supplementing nutrition and maintaining health, and includes health food, functional food, nutritional supplement, and food for specified health uses.
  • the supplement 30 includes, for example, concentrated vitamins, minerals, and other ingredients in tablet, capsule, or powder form.
  • the form of the supplement 30 is not particularly limited as long as it can be administered orally, and the supplement 30 may contain other ingredients that can be used as ingredients for supplements.
  • Other ingredients include polysaccharides, antioxidants, proteins, salts, and the like.
  • the form of the medicine 40 is not particularly limited, and the medicine 40 is used for prevention and/or treatment of target diseases or lesions.
  • the medicine 40 may contain additives or pharmaceutically acceptable carriers as needed.
  • additives or pharmaceutically acceptable carriers include excipients, disintegrants, binders, lubricants, surfactants, buffers, solubilizers, stabilizers, tonicity agents, suspending agents, Turbiding agents, emulsifiers, solvents, thickeners, mucolytic agents, wetting agents, preservatives and the like.
  • a cosmetic product 50 according to an embodiment of the present invention is characterized by containing the antibody 1 described above.
  • the type of the cosmetics 50 is not particularly limited, and the cosmetics 50 include lotion, milky lotion, foundation, lipstick, lip balm, cleansing cream, massage cream, mask, hand cream, hand powder, body shampoo, body lotion, body cream, Forms such as bath cosmetics can be included.
  • the cosmetic product 50 of the present invention preferably further contains one or more natural raw materials 2 that have a bactericidal effect and an antioxidant effect and do not cause protein denaturation of the antibody 1 .
  • the cosmetic 50 is heat-treated for the purpose of sterilization, and by controlling the pH to 4 or less, the protein may be denatured and the effect of the antibody 1 may be reduced.
  • the natural raw material 2 preferably contains a plant extract, and the plant extract preferably contains a grapefruit extract or a tea extract. Furthermore, the grapefruit extract preferably contains a grapefruit seed extract, and the tea extract preferably contains tea catechins. Grapefruit seed extracts extracted from grapefruit seeds and tea catechins extracted from tea leaves have excellent bactericidal effects.
  • the cosmetic 50 of the present invention is preferably heated and sterilized in a low temperature atmosphere of 50 to 65 ° C. It is preferable to use a manufacturing method that manufactures by The sterilization time is preferably within 60 minutes. That is, when antibody 1 is treated in a high-temperature atmosphere for a long time, protein denaturation may occur, but sterilization is performed in a low-temperature atmosphere of 50 to 65 ° C., and the sterilization time is within 60 minutes. This can suppress the occurrence of protein denaturation.
  • the cosmetic 50 of the present invention is preferably pressurized and sterilized in a high-pressure atmosphere of 500 to 1500 atm (the cosmetic 50 is produced by pressurizing and sterilizing in a high-pressure atmosphere of 500 to 1500 atm). It is preferably carried out by a manufacturing method that processes and manufactures). That is, by performing the sterilization treatment in a high-pressure atmosphere of 500 to 1500 atm, the treatment can be performed in a room temperature atmosphere, and protein denaturation can be suppressed.
  • the cosmetics 50 of the present invention are preferably sterilized using radiation (the cosmetics 50 are preferably manufactured by a manufacturing method that sterilizes using radiation). That is, by performing a sterilization treatment using radiation, it is possible to realize the treatment in a room temperature atmosphere and suppress the occurrence of protein denaturation.
  • the sterilization treatment and the sterilization treatment using radiation may each be performed alone, two or more may be appropriately combined, three or more may be appropriately combined, or all four may be performed.
  • the cosmetic 50 of the present invention further contains a negatively charged substance such as ceramics. That is, antigens (viruses) are often negatively charged, and by adding a negatively charged substance to the cosmetics 50, the negatively charged virus is repelled and the virus is prevented from adhering to the skin. can do.
  • a negatively charged substance such as ceramics.
  • antigens viruses
  • Various substances other than ceramics can be used as the negatively charged substance.
  • the cosmetic product 50 of the present invention is preferably in at least one of spray, cream, liquid, gel, paste, emulsion, and mousse. That is, by providing the cosmetic product 50 in such a form, it can be used for various purposes.
  • the spray type preferably includes a skin spray
  • the cream type includes at least one of skin cream, lip cream, nasal cavity cream, and eye area (eyelid, outer corner of the eye, lacrimal bag, etc.) cream. preferably included.
  • Antibody 2 Natural raw materials 10: Food and drink 20: Food additives 30: Supplements 40: Medicines 50: Cosmetics

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Abstract

[Problem] To provide a food or drink, a food additive, a supplement, a cosmetic, an antibody, and a drug with which it is possible to rapidly respond to a pandemic using an antibody, and to provide a manufacturing method therefor. [Solution] An antibody 1, a food or drink 10, a food additive 20, a supplement 30, a drug 40, and a cosmetic 50 according to the present invention each have added thereto an IgY antibody and/or an IgG antibody produced outside of a human body, and additionally have added thereto a natural raw material 2 having a sterilizing effect. The natural raw material 2 preferably includes a plant extract, and the plant extract preferably includes an extract extracted from grapefruit or an extract extracted from tea.

Description

[規則26に基づく補充 08.11.2022]　飲食品、食品添加物、サプリメント、化粧品、抗体、医薬、およびその製造方法[Replenishment based on Regulation 26 08.11.2022] Food and drink, food additives, supplements, cosmetics, antibodies, pharmaceuticals, and their manufacturing methods
本発明は、飲食品、食品添加物、サプリメント、化粧品、抗体、医薬、およびその製造方法に関する。 TECHNICAL FIELD The present invention relates to food and drink, food additives, supplements, cosmetics, antibodies, pharmaceuticals, and methods for producing the same.
新型コロナウイルスが猛威をふるい、世界中がパンデミックとなっているが、過去よりインフルエンザや、ＳＡＲＳ、ＭＡＲＳ等、ウィルスによるパンデミック現象は時として襲ってくる。このようなパンデミックへの対応として例えば特許文献１に示す技術が開発されている。 The new coronavirus is raging and has become a pandemic all over the world, but from the past, pandemics caused by viruses such as influenza, SARS, and MERS sometimes strike. As a countermeasure against such a pandemic, for example, a technique disclosed in Patent Literature 1 has been developed.
特開２０２０－１７２４９７号公報JP 2020-172497 A
　上記のようなパンデミックへの対応として抗体を用いた各種の技術開発が急務となっている。 There is an urgent need to develop various technologies using antibodies in response to the pandemics described above.
　本発明はこのような事情に鑑みてなされたものであり、抗体を用いてウイルスによるパンデミックへの対応を速やかに行うことができる飲食品、食品添加物、サプリメント、化粧品、抗体、医薬、およびその製造方法を提供することを目的とする。 The present invention has been made in view of such circumstances, and food and drink, food additives, supplements, cosmetics, antibodies, medicines, and their The object is to provide a manufacturing method.
上記目的を達成するために、本発明に係る飲食品は、抗体を配合したことを特徴とする。 In order to achieve the above object, the food or drink according to the present invention is characterized by containing an antibody.
本発明によれば、抗体を配合した飲食品を提供することができる。すなわち、飲食品は、ワクチンや医薬品等で見られる臨床（治験）の必要がなく抗体を用いてウイルスによるパンデミックへの対応を速やかに行うことができる。 INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide a food or drink containing an antibody. In other words, food and drink can quickly respond to pandemics caused by viruses using antibodies without the need for clinical trials (trials) that are required for vaccines, pharmaceuticals, and the like.
本発明の飲食品は、更に殺菌効果を有する天然系原料を配合することが好ましい。
前記天然系原料は、植物エキスを含むことが好ましい。
前記植物エキスは、グレープフルーツ抽出エキスまたは茶抽出エキスを含むことが好ましい。
前記グレープフルーツ抽出エキスは、グレープフルーツ種子抽出エキスを含むことが好ましい。
前記茶抽出エキスは、茶カテキンを含むことが好ましい。 It is preferable that the food and drink of the present invention further contain a natural raw material having a bactericidal effect.
The natural raw material preferably contains a plant extract.
The plant extract preferably contains a grapefruit extract or a tea extract.
The grapefruit extract preferably contains a grapefruit seed extract.
The tea extract preferably contains tea catechins.
本発明の飲食品は、５０℃乃至６５℃の低温雰囲気下で加熱され殺菌処理されることが好ましい。
前記殺菌処理の時間は、６０分以内とすることが好ましい。
本発明の飲食品は、５００気圧乃至１５００気圧の高圧雰囲気下で加圧され殺菌処理されることが好ましい。
本発明の飲食品は、放射線を用いて殺菌処理されることが好ましい。 The food and drink of the present invention are preferably sterilized by heating in a low temperature atmosphere of 50°C to 65°C.
The sterilization time is preferably within 60 minutes.
The food and drink of the present invention are preferably pressurized and sterilized in a high pressure atmosphere of 500 to 1500 atm.
The food and drink of the present invention are preferably sterilized using radiation.
本発明の飲食品は、スプレー状、ゼリー状、飴状、カプセル状、タブレット状、丸状、粉末状、顆粒状、細粒状、トローチ状、液状、またはゲル状とすることが好ましい。
前記スプレー状は、口腔内用スプレーの形態とすることが好ましい。
前記カプセル状は、腸溶カプセルの形態とすることが好ましい。
乳製品、発酵食品、およびドリンク類の少なくともいずれかとすることが好ましい。 The food or drink of the present invention is preferably spray, jelly, candy, capsule, tablet, round, powder, granule, fine grain, troche, liquid or gel.
The spray form is preferably in the form of an intraoral spray.
The capsule is preferably in the form of an enteric capsule.
At least one of dairy products, fermented foods, and drinks is preferred.
前記抗体は、人体外で作製した抗体とすることが好ましい。
前記抗体は、ＩｇＹ抗体および／またはＩｇＧ抗体を含むことが好ましい。 The antibody is preferably an antibody produced outside the human body.
Said antibody preferably comprises an IgY antibody and/or an IgG antibody.
上記目的を達成するために、本発明に係る食品添加物は、抗体を配合したことを特徴とする。
本発明によれば、抗体を配合した食品添加物を提供することができる。すなわち、食品添加物は、ワクチンや医薬品等で見られる臨床（治験）の必要がなく抗体を用いてウイルスによるパンデミックへの対応を速やかに行うことができる。 In order to achieve the above object, the food additive according to the present invention is characterized by containing an antibody.
According to the present invention, an antibody-containing food additive can be provided. In other words, food additives can quickly respond to pandemics caused by viruses using antibodies without the need for clinical trials (trials) that are required for vaccines, pharmaceuticals, and the like.
本発明の食品添加物は、更に殺菌効果を有する天然系原料を配合することが好ましい。
前記天然系原料は、植物エキスを含むことが好ましい。
前記植物エキスは、グレープフルーツ抽出エキスまたは茶抽出エキスを含むことが好ましい。
前記グレープフルーツ抽出エキスは、グレープフルーツ種子抽出エキスを含むことが好ましい。 It is preferable that the food additive of the present invention further contains a natural raw material having a bactericidal effect.
The natural raw material preferably contains a plant extract.
The plant extract preferably contains a grapefruit extract or a tea extract.
The grapefruit extract preferably contains a grapefruit seed extract.
前記茶抽出エキスは、茶カテキンを含むことが好ましい。
食品添加物は、５０℃乃至６５℃の低温雰囲気下で加熱され殺菌処理されることが好ましい。
前記殺菌処理の時間は、６０分以内とすることが好ましい。 The tea extract preferably contains tea catechins.
The food additive is preferably sterilized by heating in a low temperature atmosphere of 50°C to 65°C.
The sterilization time is preferably within 60 minutes.
本発明の食品添加物は、５００気圧乃至１５００気圧の高圧雰囲気下で加圧され殺菌処理されることが好ましい。
本発明の食品添加物は、放射線を用いて殺菌処理されることが好ましい。 The food additive of the present invention is preferably pressurized and sterilized in a high pressure atmosphere of 500 to 1500 atm.
The food additive of the present invention is preferably sterilized using radiation.
本発明の食品添加物は、スプレー状、ゼリー状、飴状、カプセル状、タブレット状、丸状、粉末状、顆粒状、細粒状、トローチ状、液状、またはゲル状とすることが好ましい。 The food additive of the present invention is preferably in the form of spray, jelly, candy, capsule, tablet, round, powder, granule, fine grain, troche, liquid or gel.
前記スプレー状は、口腔内用スプレーの形態とすることが好ましい。
前記カプセル状は、腸溶カプセルの形態とすることが好ましい。
前記抗体は、人体外で作製した抗体とすることが好ましい。
前記抗体は、ＩｇＹ抗体および／またはＩｇＧ抗体を含むことが好ましい。
本発明の食品添加物は、乳製品、発酵食品、およびドリンク類の少なくともいずれかとすることが好ましい。 The spray form is preferably in the form of an intraoral spray.
The capsule is preferably in the form of an enteric capsule.
The antibody is preferably an antibody produced outside the human body.
Said antibody preferably comprises an IgY antibody and/or an IgG antibody.
The food additive of the present invention is preferably at least one of dairy products, fermented foods, and drinks.
上記目的を達成するために、本発明に係るサプリメントは、抗体を配合したことを特徴とする。
本発明によれば、抗体を配合したサプリメントを提供することができる。すなわち、サプリメントは、ワクチンや医薬品等で見られる臨床（治験）の必要がなく抗体を用いてウイルスによるパンデミックへの対応を速やかに行うことができる。 In order to achieve the above object, a supplement according to the present invention is characterized by containing an antibody.
According to the present invention, a supplement containing an antibody can be provided. In other words, supplements can quickly respond to pandemics caused by viruses using antibodies without the need for clinical trials (trials) that are required for vaccines, pharmaceuticals, and the like.
本発明のサプリメントは、更に殺菌効果を有する天然系原料を配合することが好ましい。
前記天然系原料は、植物エキスを含むことが好ましい。
前記植物エキスは、グレープフルーツ抽出エキスまたは茶抽出エキスを含むことが好ましい。
前記グレープフルーツ抽出エキスは、グレープフルーツ種子抽出エキスを含むことが好ましい。
前記茶抽出エキスは、茶カテキンを含むことが好ましい。 The supplement of the present invention preferably further contains natural raw materials having a bactericidal effect.
The natural raw material preferably contains a plant extract.
The plant extract preferably contains a grapefruit extract or a tea extract.
The grapefruit extract preferably contains a grapefruit seed extract.
The tea extract preferably contains tea catechins.
本発明のサプリメントは、５０℃乃至６５℃の低温雰囲気下で加熱され殺菌処理されることが好ましい。
前記殺菌処理の時間は、６０分以内とすることが好ましい。
本発明のサプリメントは、５００気圧乃至１５００気圧の高圧雰囲気下で加圧され殺菌処理されることが好ましい。
本発明のサプリメントは、放射線を用いて殺菌処理されることが好ましい。
本発明のサプリメントは、スプレー状、ゼリー状、飴状、カプセル状、タブレット状、丸状、粉末状、顆粒状、細粒状、トローチ状、液状、またはゲル状とすることが好ましい。 The supplement of the present invention is preferably sterilized by heating in a low temperature atmosphere of 50°C to 65°C.
The sterilization time is preferably within 60 minutes.
The supplement of the present invention is preferably pressurized and sterilized under a high pressure atmosphere of 500 to 1500 atm.
The supplement of the present invention is preferably sterilized using radiation.
The supplement of the present invention is preferably in the form of spray, jelly, candy, capsule, tablet, round, powder, granule, fine grain, troche, liquid or gel.
前記スプレー状は、口腔内用スプレーの形態とすることが好ましい。
前記カプセル状は、腸溶カプセルの形態とすることが好ましい。
前記抗体は、人体外で作製した抗体とすることが好ましい。
前記抗体は、ＩｇＹ抗体および／またはＩｇＧ抗体を含むことが好ましい。
サプリメントは、乳製品、発酵食品、およびドリンク類の少なくともいずれかとすることが好ましい。 The spray form is preferably in the form of an intraoral spray.
The capsule is preferably in the form of an enteric capsule.
The antibody is preferably an antibody produced outside the human body.
Said antibody preferably comprises an IgY antibody and/or an IgG antibody.
The supplement is preferably at least one of dairy products, fermented foods, and drinks.
上記目的を達成するために、本発明に係る化粧品は、抗体を配合したことを特徴とする。
本発明によれば、抗体を配合した化粧品を提供することができる。すなわち、化粧品は、ワクチンや医薬品等で見られる臨床（治験）の必要がなく抗体を用いてウイルスによるパンデミックへの対応を速やかに行うことができる。
本発明の化粧品は、更に殺菌効果を有する天然系原料を配合することが好ましい。
前記天然系原料は、植物エキスを含むことが好ましい。
前記植物エキスは、グレープフルーツ抽出エキスまたは茶抽出エキスを含むことが好ましい。
前記グレープフルーツ抽出エキスは、グレープフルーツ種子抽出エキスを含むことが好ましい。
前記茶抽出エキスは、茶カテキンを含むことが好ましい。 In order to achieve the above object, the cosmetic according to the present invention is characterized by containing an antibody.
According to the present invention, cosmetics containing antibodies can be provided. In other words, cosmetics can quickly respond to pandemics caused by viruses using antibodies without the need for clinical trials (trials) that are required for vaccines, pharmaceuticals, and the like.
It is preferable that the cosmetic of the present invention further contain a natural raw material having a bactericidal effect.
The natural raw material preferably contains a plant extract.
The plant extract preferably contains a grapefruit extract or a tea extract.
The grapefruit extract preferably contains a grapefruit seed extract.
The tea extract preferably contains tea catechins.
本発明の化粧品は、５０℃乃至６５℃の低温雰囲気下で加熱され殺菌処理されることが好ましい。
前記殺菌処理の時間は、６０分以内とすることが好ましい。
本発明の化粧品は、５００気圧乃至１５００気圧の高圧雰囲気下で加圧され殺菌処理されることが好ましい。
本発明の化粧品は、放射線を用いて殺菌処理されることが好ましい。
本発明の化粧品は、更にマイナスに帯電した物質を配合することが好ましい。 The cosmetic of the present invention is preferably sterilized by heating in a low temperature atmosphere of 50°C to 65°C.
The sterilization time is preferably within 60 minutes.
The cosmetics of the present invention are preferably pressurized and sterilized in a high-pressure atmosphere of 500 to 1500 atm.
The cosmetics of the present invention are preferably sterilized using radiation.
The cosmetic of the present invention preferably further contains a negatively charged substance.
本発明の化粧品は、スプレー状、クリーム状、液状、ゲル状、ペースト状、乳液状、およびムース状の少なくともいずれかであることが好ましい。
前記スプレー状は、皮膚用スプレーを含むことが好ましい。
前記クリーム状は、皮膚用クリーム、唇用クリーム、鼻腔用クリーム、および目周り用クリームの少なくともいずれかを含むことが好ましい。
前記抗体は、人体外で作製した抗体とすることが好ましい。
前記抗体は、ＩｇＹ抗体および／またはＩｇＧ抗体を含むことが好ましい。 The cosmetic product of the present invention is preferably in at least one of spray, cream, liquid, gel, paste, emulsion, and mousse.
The spray form preferably includes a skin spray.
The cream preferably includes at least one of skin cream, lip cream, nasal cavity cream, and eye cream.
The antibody is preferably an antibody produced outside the human body.
Said antibody preferably comprises an IgY antibody and/or an IgG antibody.
上記目的を達成するために、本発明に係る抗体は、人体外で作製したことを特徴とし、ＩｇＹ抗体および／またはＩｇＧ抗体を含むことが好ましい。
上記目的を達成するために、本発明に係る医薬は、抗体を配合したことを特徴とする。 In order to achieve the above object, the antibody according to the present invention is characterized by being produced outside the human body, and preferably contains an IgY antibody and/or an IgG antibody.
In order to achieve the above object, the pharmaceutical according to the present invention is characterized by containing an antibody.
本発明の医薬は、更に殺菌効果を有する天然系原料を配合することが好ましい。
前記天然系原料は、植物エキスを含むことが好ましい。
前記植物エキスは、グレープフルーツ抽出エキスまたは茶抽出エキスを含むことが好ましい。
前記グレープフルーツ抽出エキスは、グレープフルーツ種子抽出エキスを含むことが好ましい。
前記茶抽出エキスは、茶カテキンを含むことが好ましい。 It is preferable that the medicament of the present invention further contains a natural raw material having a bactericidal effect.
The natural raw material preferably contains a plant extract.
The plant extract preferably contains a grapefruit extract or a tea extract.
The grapefruit extract preferably contains a grapefruit seed extract.
The tea extract preferably contains tea catechins.
本発明の医薬は、５０℃乃至６５℃の低温雰囲気下で加熱され殺菌処理されることが好ましい。
前記殺菌処理の時間は、６０分以内とすることが好ましい。
本発明の医薬は、５００気圧乃至１５００気圧の高圧雰囲気下で加圧され殺菌処理されることが好ましい。
本発明の医薬は、放射線を用いて殺菌処理されることが好ましい。
本発明の医薬は、スプレー状、ゼリー状、飴状、カプセル状、タブレット状、丸状、粉末状、顆粒状、細粒状、トローチ状、液状、またはゲル状とすることが好ましい。
前記スプレー状は、口腔内用スプレーの形態とすることが好ましい。
前記カプセル状は、腸溶カプセルの形態とすることが好ましい。 The medicament of the present invention is preferably sterilized by heating in a low temperature atmosphere of 50°C to 65°C.
The sterilization time is preferably within 60 minutes.
The pharmaceutical of the present invention is preferably pressurized and sterilized in a high-pressure atmosphere of 500 to 1500 atm.
The medicament of the present invention is preferably sterilized using radiation.
The medicament of the present invention is preferably in the form of spray, jelly, candy, capsule, tablet, round, powder, granule, fine grain, troche, liquid, or gel.
The spray form is preferably in the form of an intraoral spray.
The capsule is preferably in the form of an enteric capsule.
本発明の医薬は、乳製品、発酵食品、およびドリンク類の少なくともいずれかとすることが好ましい。
前記抗体は、人体外で作製したことが好ましい。
前記抗体は、ＩｇＹ抗体および／またはＩｇＧ抗体を含むことが好ましい。
本発明の医薬は、対象の感染症を予防および／または治療するために用いることが好ましい。
前記感染症は、コロナウイルス、インフルエンザ、ＳＡＲＳ、およびＭＡＲＳから構成される群から選ばれる１種または複数の感染症を含むことが好ましい。
前記対象は、哺乳類とすることが好ましくは、前記哺乳類は、ヒトとすることが好ましい。 The pharmaceutical of the present invention is preferably at least one of dairy products, fermented foods, and drinks.
The antibody is preferably produced outside the human body.
Said antibody preferably comprises an IgY antibody and/or an IgG antibody.
The medicament of the present invention is preferably used to prevent and/or treat infectious diseases in subjects.
The infectious disease preferably includes one or more infectious diseases selected from the group consisting of coronavirus, influenza, SARS, and MARS.
The subject is preferably a mammal, and the mammal is preferably a human.
上記目的を達成するために、本発明に係る製造方法は、抗体、抗体を配合した飲食品、食品添加物、サプリメント、化粧品、および医薬の少なくともいずれかを５０℃乃至６５℃の低温雰囲気下で加熱し殺菌処理して製造することを特徴とする。
本発明の製造方法は、前記殺菌処理の時間は、６０分以内とすることが好ましい。
本発明の製造方法は、５００気圧乃至１５００気圧の高圧雰囲気下で加圧され殺菌処理されることが好ましい。
製造方法は、抗体、抗体を配合した飲食品、食品添加物、サプリメント、化粧品、および医薬の少なくともいずれかを放射線を用いて殺菌処理して製造することが好ましい。 In order to achieve the above object, the production method according to the present invention provides antibodies, antibody-blended foods and drinks, food additives, supplements, cosmetics, and at least one of pharmaceuticals in a low-temperature atmosphere of 50°C to 65°C. It is characterized by being manufactured by heating and sterilizing.
In the production method of the present invention, the sterilization time is preferably within 60 minutes.
In the production method of the present invention, it is preferable that the sterilization treatment is carried out under a high pressure atmosphere of 500 to 1500 atm.
As for the production method, it is preferable to sterilize at least one of antibodies, antibody-containing foods and drinks, food additives, supplements, cosmetics, and pharmaceuticals using radiation.
本発明によれば、抗体を用いてウイルスによるパンデミックへの対応を速やかに行うことができる。 INDUSTRIAL APPLICABILITY According to the present invention, antibodies can be used to promptly respond to viral pandemics.
本発明の実施形態に係る抗体、飲食品、食品添加物、サプリメント、医薬、化粧品を示す図である。BRIEF DESCRIPTION OF THE DRAWINGS It is a figure which shows the antibody, food/beverage products, food additive, supplement, medicine, and cosmetics which concern on embodiment of this invention.
　以下、本発明の抗体、飲食品、食品添加物、サプリメント、医薬、化粧品、およびその製造方法の実施形態を詳細に説明する。図１は、本発明の実施形態に係る抗体１、飲食品１０、食品添加物２０、サプリメント３０、医薬４０、化粧品５０を示す図である。 Embodiments of the antibodies, food and drink, food additives, supplements, medicines, cosmetics, and methods for producing the same of the present invention are described in detail below. FIG. 1 is a diagram showing an antibody 1, a food or drink 10, a food additive 20, a supplement 30, a medicine 40, and a cosmetic 50 according to an embodiment of the present invention.
[抗体１]
抗体１は、人体外で作製した抗体１とすることが好ましく、更に、抗体１は、ＩｇＹ抗体より詳しくは鶏卵由来の免疫ブログリンであるＩｇＹ抗体および／またはＩｇＧ抗体より詳しくはマウス由来の免疫グロブリンであるＩｇＧ抗体を含むことが好ましい。ＩｇＹ抗体およびＩｇＧ抗体は、モノクローナル抗体またはポリクローナル抗体を含むことが好ましい。ＩｇＹ抗体は、鶏卵から抽出した抽出物を培養・精製して作製することができ、ＩｇＧ抗体は、マウスから抽出した抽出物を培養・精製して作製することができる。人体外（鶏卵やマウス等の人体外）で作製された抗体１は、人体を抗原により免疫させる必要がないため、アレルギー反応のリスクがないとされている。ＩｇＹ抗体およびＩｇＧ抗体は、抗原の中和より詳しくはウイルス本体、ウィルスたんぱく質、ウイルス遺伝子、およびＡＣＥ２受容体タンパク質（スパイクタンパク質）の中和をすることができる。 [Antibody 1]
The antibody 1 is preferably an antibody 1 produced outside the human body, and the antibody 1 is more specifically an IgY antibody, which is an immunoglobulin derived from chicken eggs, and/or an IgG antibody. More specifically, an antibody derived from a mouse. It preferably includes an IgG antibody that is a globulin. IgY and IgG antibodies preferably include monoclonal or polyclonal antibodies. An IgY antibody can be produced by culturing and purifying an extract extracted from chicken eggs, and an IgG antibody can be produced by culturing and purifying an extract extracted from a mouse. Antibody 1 produced outside the human body (external to the human body such as a hen's egg or a mouse) does not need to immunize the human body with an antigen, so it is said that there is no risk of allergic reaction. IgY antibodies and IgG antibodies are capable of neutralizing antigens, more specifically neutralizing viral bodies, viral proteins, viral genes, and ACE2 receptor proteins (spike proteins).
ここで、抗体（例えば、免疫グロブリン）１とは、リンパ球のうちＢ細胞の産生する糖タンパク分子で、特定のタンパク質などの分子（抗原）を認識して結合する働きをもつ。抗体１は主に血液中や体液中に存在し、例えば、体内に侵入してきた細菌やウィルス、微生物に感染した細胞を抗原として認識して結合する。抗体１が抗原へ結合すると、その抗原と抗体１の複合体を白血球やマイクロファージといった食細胞が認識・貪食して体内から除去するように働いたり、リンパ球などの免疫細胞が結合して免疫反応を引き起こしたりするものである。 Here, the antibody (for example, immunoglobulin) 1 is a glycoprotein molecule produced by B cells among lymphocytes, and has the function of recognizing and binding to a molecule (antigen) such as a specific protein. Antibody 1 is mainly present in blood and body fluids, and recognizes and binds to, for example, bacteria, viruses, and cells infected with microorganisms that have invaded the body as antigens. When Antibody 1 binds to an antigen, phagocytic cells such as leukocytes and microphages recognize and phagocytize the complex of the antigen and Antibody 1 and work to remove it from the body, and immune cells such as lymphocytes bind and become immune. It is something that provokes a reaction.
[飲食品１０、食品添加物２０、サプリメント３０、医薬４０の実施形態]
本発明の実施形態に係る飲食品１０、食品添加物２０、サプリメント３０、医薬４０は、上記の抗体１を配合したことを特徴とする。
本発明の飲食品１０、食品添加物２０、サプリメント３０、医薬４０は、更に殺菌効果および抗酸化効果があり抗体１のタンパク質変性を生じさせない一種以上の天然系原料２を配合することが好ましい。飲食品１０、食品添加物２０、サプリメント３０、医薬４０は、例えば殺菌を目的に加熱処理を行うこと、ｐＨを４以下にコントロールすることで、タンパク質が変性し抗体１の効果が低下することがあるが、殺菌効果および抗酸化効果があり抗体１のタンパク質変性を生じさせない一種以上の天然系原料２を配合することにより、加熱処理を行うことなくｐＨを４以下にコントロールすることもなく、抗体１がタンパク質変性することを抑制することができる。 [Embodiments of Food and Beverage 10, Food Additive 20, Supplement 30, and Medicine 40]
The food and drink 10, the food additive 20, the supplement 30, and the medicine 40 according to the embodiment of the present invention are characterized by containing the antibody 1 described above.
The food and drink 10, the food additive 20, the supplement 30, and the medicine 40 of the present invention preferably further contain one or more natural raw materials 2 that have bactericidal and antioxidant effects and do not cause protein denaturation of the antibody 1. The food and drink 10, the food additive 20, the supplement 30, and the medicine 40 are subjected to heat treatment for the purpose of sterilization, for example, and by controlling the pH to 4 or less, the protein is denatured and the effect of the antibody 1 is reduced. However, by blending one or more natural raw materials 2 that have a bactericidal effect and an antioxidant effect and do not cause protein denaturation of the antibody 1, the antibody can be obtained without heat treatment and without controlling the pH to 4 or less. 1 can suppress protein denaturation.
天然系原料２は、植物エキスを含むことが好ましく、植物エキスは、グレープフルーツ抽出エキスまたは茶抽出エキスを含むことが好ましい。更に、グレープフルーツ抽出エキスは、グレープフルーツ種子抽出エキスを含むことが好ましく、茶抽出エキスは、茶カテキンを含むことが好ましい。グレープフルーツの種子から抽出されたグレープフルーツ種子抽出エキスや茶葉から抽出された茶カテキンは、殺菌効果に優れる。 The natural raw material 2 preferably contains a plant extract, and the plant extract preferably contains a grapefruit extract or a tea extract. Furthermore, the grapefruit extract preferably contains a grapefruit seed extract, and the tea extract preferably contains tea catechins. Grapefruit seed extracts extracted from grapefruit seeds and tea catechins extracted from tea leaves have excellent bactericidal effects.
また、本発明の飲食品１０、食品添加物２０、サプリメント３０、医薬４０は、５０℃乃至６５℃の低温雰囲気下で加熱され殺菌処理されることが好ましい（飲食品１０、食品添加物２０、サプリメント３０、医薬４０の製造は、５０℃乃至６５℃の低温雰囲気下で加熱し殺菌処理して製造する製造方法により行うことが好ましい）。殺菌処理の時間は、６０分以内とすることが好ましい。すなわち、抗体１を高温雰囲気下で長時間処理した場合には、タンパク質変性を起こすことがあるが、５０℃乃至６５℃の低温雰囲気下で殺菌処理し、殺菌処理の時間を６０分以内とすることでタンパク質変性が生じることを抑制することができる。 In addition, the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 of the present invention are preferably heated and sterilized in a low-temperature atmosphere of 50°C to 65°C (the food and drink 10, the food additive 20, The supplement 30 and the medicine 40 are preferably manufactured by a manufacturing method in which they are heated and sterilized in a low temperature atmosphere of 50° C. to 65° C.). The sterilization time is preferably within 60 minutes. That is, when antibody 1 is treated in a high-temperature atmosphere for a long time, protein denaturation may occur, but sterilization is performed in a low-temperature atmosphere of 50 to 65 ° C., and the sterilization time is within 60 minutes. This can suppress the occurrence of protein denaturation.
更に、本発明の飲食品１０、食品添加物２０、サプリメント３０、医薬４０は、５００気圧乃至１５００気圧の高圧雰囲気下で加圧され殺菌処理されることが好ましい（飲食品１０、食品添加物２０、サプリメント３０、医薬４０の製造は、５００気圧乃至１５００気圧の高圧雰囲気下で加圧され殺菌処理して製造する製造方法により行うことが好ましい）。すなわち、５００気圧乃至１５００気圧の高圧雰囲気下で殺菌処理を行うことで常温雰囲気下での処理が実現できタンパク質変性が生じることを抑制することができる。 Furthermore, the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 of the present invention are preferably pressurized and sterilized in a high pressure atmosphere of 500 to 1500 atm (the food and drink 10, the food additive 20 , the supplement 30 and the medicine 40 are preferably manufactured by a manufacturing method in which they are pressurized and sterilized in a high-pressure atmosphere of 500 to 1500 atm). That is, by performing the sterilization treatment in a high-pressure atmosphere of 500 to 1500 atm, the treatment can be performed in a room temperature atmosphere, and protein denaturation can be suppressed.
更にまた、本発明の飲食品１０、食品添加物２０、サプリメント３０、医薬４０は、放射線を用いて殺菌処理されることが好ましい（飲食品１０、食品添加物２０、サプリメント３０、医薬４０の製造は、放射線を用いて殺菌処理して製造する製造方法により行うことが好ましい）。すなわち、放射線を用いた殺菌処理を行うことで常温雰囲気下での処理が実現できタンパク質変性が生じることを抑制することができる。 Furthermore, the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 of the present invention are preferably sterilized using radiation (manufacturing of the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 is preferably carried out by a manufacturing method in which radiation is used to sterilize and manufacture). That is, by performing a sterilization treatment using radiation, it is possible to realize the treatment in a room temperature atmosphere and suppress the occurrence of protein denaturation.
本発明の飲食品１０、食品添加物２０、サプリメント３０、医薬４０にタンパク質変性を抑制する手法として上述した一種以上の天然系原料２の配合、５０℃乃至６５℃の低温雰囲気下での殺菌処理、５００気圧乃至１５００気圧の高圧雰囲気下での殺菌処理、放射線を用いた殺菌処理は、それぞれ単独で行うこととしてもよく、二つ以上を適宜組み合わせることとしてよく、三つ以上を適宜組み合わせることとしてよく、四つ全てを行うこととしてもよい。 Blending of one or more natural raw materials 2 described above as a method of suppressing protein denaturation in the food and drink 10, food additive 20, supplement 30, and medicine 40 of the present invention, and sterilization in a low temperature atmosphere of 50 to 65 °C. , sterilization treatment under a high pressure atmosphere of 500 to 1500 atm, and sterilization treatment using radiation may be performed alone, may be appropriately combined with two or more, or may be appropriately combined with three or more. Well, you can do all four.
ここで、本発明の飲食品１０、食品添加物２０、サプリメント３０、医薬４０は、スプレー状、ゼリー状、飴状、カプセル状、タブレット状、丸状、粉末状、顆粒状、細粒状、トローチ状、液状、またはゲル状とすることが好ましい。すなわち、飲食品１０、食品添加物２０、サプリメント３０、医薬４０をこのような形態で提供することで、様々な用途に用いることができる。 Here, the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 of the present invention are spray-like, jelly-like, candy-like, capsule-like, tablet-like, round-like, powder-like, granule-like, fine-grain-like, troche. It is preferably in the form of liquid, liquid or gel. That is, by providing the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 in such a form, they can be used for various purposes.
例えば、スプレー状は、口腔内用スプレーの形態とすることでき、カプセル状は、腸溶カプセルの形態とすることができる。 For example, the spray form can be in the form of an oral spray, and the capsule form can be in the form of an enteric capsule.
また、飲食品１０、食品添加物２０、サプリメント３０、医薬４０は、乳製品、発酵食品、およびドリンク類の少なくともいずれかとすることができる。乳製品は、例えば、乳酸菌飲料、ヨーグルト等とすることができ、発酵食品は、納豆、キムチ等とすることができ、ドリンク類は、ジュース、健康ドリンク、スポーツドリンク等とすることができる。飲食品１０、食品添加物２０、サプリメント３０、医薬４０をこのような形態とすることで抗体１を配合した飲食品１０、食品添加物２０、サプリメント３０、医薬４０を摂取しやすくすることができる。 Also, the food and drink 10, the food additive 20, the supplement 30, and the medicine 40 can be at least one of dairy products, fermented foods, and drinks. Dairy products can be, for example, lactic acid beverages, yogurt, etc. Fermented foods can be natto, kimchi, etc., and drinks can be juices, health drinks, sports drinks, and the like. By forming the food/beverage product 10, the food additive 20, the supplement 30, and the medicine 40 in such a form, it is possible to facilitate ingestion of the food/beverage product 10, the food additive 20, the supplement 30, and the medicine 40 containing the antibody 1. .
更に、医薬４０は、対象の感染症を予防および／または治療するために用いることができる。感染症は、コロナウイルス、インフルエンザ、ＳＡＲＳ、およびＭＡＲＳから構成される群から選ばれる１種または複数の感染症を含むことができる。対象は、哺乳類とすることができ、哺乳類は、ヒトとすることができる。 Additionally, medicament 40 can be used to prevent and/or treat infections in a subject. Infectious diseases can include one or more infectious diseases selected from the group consisting of coronavirus, influenza, SARS, and MARS. The subject can be a mammal, and the mammal can be a human.
上記の飲食品１０、食品添加物２０、サプリメント３０、医薬４０を摂取することにより、抗体１を用いてウイルスによるパンデミックへの対応を速やかに行うことができる。 By ingesting the food and drink 10, the food additive 20, the supplement 30, and the medicine 40, the antibody 1 can be used to promptly respond to a virus pandemic.
また、上記の飲食品１０、食品添加物２０、サプリメント３０を摂取することにより、ワクチンや医薬品等で見られる臨床（治験）の必要がなく抗体１を用いてウイルスによるパンデミックへの対応を速やかに行うことができる。 In addition, by ingesting the above-mentioned food and drink 10, food additives 20, and supplements 30, there is no need for clinical trials (trials) seen with vaccines, pharmaceuticals, etc., and antibody 1 can be used to quickly respond to pandemics caused by viruses. It can be carried out.
なお、上記した飲食品１０の種類は、特に制限されず、飲食品１０は、飲料、食品を含む。飲食品１０は、飲料類、麺類、菓子類、肉類又は畜産加工食品、穀物加工食品、野菜加工食品、果物加工食品、乳製品、油脂加工品、調味料等を含む。 The type of food and drink 10 described above is not particularly limited, and food and drink 10 includes beverages and foods. The food and drink 10 include beverages, noodles, confectionery, meat or livestock processed foods, grain processed foods, vegetable processed foods, fruit processed foods, dairy products, oil and fat processed foods, seasonings and the like.
また、食品添加物２０とは、飲食品１０の加工または保存の目的で添加される物質であり、酸化現象を低減するため、商品を着色するため、その味を増強するため等の技術的目的のために食品に添加される。食品添加物２０は、着色剤（ホワイトニング剤を含む）、防腐剤、酸化防止剤、酸味料／酸性度補正剤及び食感付与剤（安定剤、乳化剤、増粘剤、ゲル化剤）等を含む。食品添加物２０は、必要に応じて食品用添加物２０用の他の成分を含んでもよい。他の成分としては、着色料、保存料、甘味料、増粘剤、安定剤、ゲル化剤、酸化防止剤、乳化剤、香料などが挙げられる。 In addition, the food additive 20 is a substance added for the purpose of processing or preserving the food and drink 10, and has technical purposes such as reducing oxidation, coloring the product, enhancing its taste, and the like. added to food for Food additives 20 include coloring agents (including whitening agents), preservatives, antioxidants, acidulants/acidity correctors, and texture imparting agents (stabilizers, emulsifiers, thickeners, gelling agents), and the like. include. The food additive 20 may contain other ingredients for the food additive 20 as desired. Other ingredients include colorants, preservatives, sweeteners, thickeners, stabilizers, gelling agents, antioxidants, emulsifiers, flavors and the like.
更に、サプリメント３０は、栄養補助、健康維持を目的とする食品に分類される組成物を指し、健康食品、機能性食品、栄養補助食品、特定保健用食品を含む。サプリメント３０は、例えば、ビタミンやミネラル等の成分を濃縮し、錠剤、カプセル又は粉末状にしたものを含む。サプリメント３０の形態は経口投与可能であれば特に制限されず、サプリメント３０は、サプリメント用の成分として使用可能な他の成分を含んでもよい。他の成分としては、多糖類、酸化防止剤、タンパク質、塩類などが挙げられる。 Further, the supplement 30 refers to a composition classified as a food for the purpose of supplementing nutrition and maintaining health, and includes health food, functional food, nutritional supplement, and food for specified health uses. The supplement 30 includes, for example, concentrated vitamins, minerals, and other ingredients in tablet, capsule, or powder form. The form of the supplement 30 is not particularly limited as long as it can be administered orally, and the supplement 30 may contain other ingredients that can be used as ingredients for supplements. Other ingredients include polysaccharides, antioxidants, proteins, salts, and the like.
更にまた、医薬４０の形態は、特に制限されず、医薬４０は、対象の疾患や病変の予防および／または治療するために用いるものである。医薬４０は、必要に応じて添加物又は薬学的に許容可能な担体を含んでもよい。このような添加物又は薬学的に許容可能な担体としては、賦形剤、崩壊剤、結合剤、潤滑剤、界面活性剤、緩衝剤、溶解補助剤、安定化剤、等張化剤、懸濁化剤、乳化剤、溶剤、増粘剤、粘液溶解剤、湿潤剤、防腐剤などが挙げられる。 Furthermore, the form of the medicine 40 is not particularly limited, and the medicine 40 is used for prevention and/or treatment of target diseases or lesions. The medicine 40 may contain additives or pharmaceutically acceptable carriers as needed. Such additives or pharmaceutically acceptable carriers include excipients, disintegrants, binders, lubricants, surfactants, buffers, solubilizers, stabilizers, tonicity agents, suspending agents, Turbiding agents, emulsifiers, solvents, thickeners, mucolytic agents, wetting agents, preservatives and the like.
[化粧品５０の実施形態]
本発明の実施形態に係る化粧品５０は、上記の抗体１を配合したことを特徴とする。化粧品５０の種類は、特に制限されず、化粧品５０は、化粧水、乳液、ファンデーション、口紅、リップクリーム、クレンジングクリーム、マッサージクリーム、パック、ハンドクリーム、ハンドパウダー、ボディシャンプー、ボディローション、ボディクリーム、浴用化粧品等の形態を含むことができる。 [Embodiment of cosmetics 50]
A cosmetic product 50 according to an embodiment of the present invention is characterized by containing the antibody 1 described above. The type of the cosmetics 50 is not particularly limited, and the cosmetics 50 include lotion, milky lotion, foundation, lipstick, lip balm, cleansing cream, massage cream, mask, hand cream, hand powder, body shampoo, body lotion, body cream, Forms such as bath cosmetics can be included.
本発明の化粧品５０は、更に殺菌効果および抗酸化効果があり抗体１のタンパク質変性を生じさせない一種以上の天然系原料２を配合することが好ましい。化粧品５０は、例えば殺菌を目的に加熱処理を行うこと、ｐＨを４以下にコントロールすることで、タンパク質が変性し抗体１の効果が低下することがあるが、殺菌効果および抗酸化効果があり抗体１のタンパク質変性を生じさせない一種以上の天然系原料２を配合することにより、加熱処理を行うことなくｐＨを４以下にコントロールすることもなく、抗体１がタンパク質変性することを抑制することができる。 The cosmetic product 50 of the present invention preferably further contains one or more natural raw materials 2 that have a bactericidal effect and an antioxidant effect and do not cause protein denaturation of the antibody 1 . For example, the cosmetic 50 is heat-treated for the purpose of sterilization, and by controlling the pH to 4 or less, the protein may be denatured and the effect of the antibody 1 may be reduced. By blending one or more natural raw materials 2 that do not cause protein denaturation of 1, it is possible to suppress protein denaturation of antibody 1 without performing heat treatment and without controlling pH to 4 or less. .
天然系原料２は、植物エキスを含むことが好ましく、植物エキスは、グレープフルーツ抽出エキスまたは茶抽出エキスを含むことが好ましい。更に、グレープフルーツ抽出エキスは、グレープフルーツ種子抽出エキスを含むことが好ましく、茶抽出エキスは、茶カテキンを含むことが好ましい。グレープフルーツの種子から抽出されたグレープフルーツ種子抽出エキスや茶葉から抽出された茶カテキンは、殺菌効果に優れる。 The natural raw material 2 preferably contains a plant extract, and the plant extract preferably contains a grapefruit extract or a tea extract. Furthermore, the grapefruit extract preferably contains a grapefruit seed extract, and the tea extract preferably contains tea catechins. Grapefruit seed extracts extracted from grapefruit seeds and tea catechins extracted from tea leaves have excellent bactericidal effects.
また、本発明の化粧品５０は、５０℃乃至６５℃の低温雰囲気下で加熱され殺菌処理されることが好ましい（化粧品５０の製造は、５０℃乃至６５℃の低温雰囲気下で加熱し殺菌処理して製造する製造方法により行うことが好ましい）。殺菌処理の時間は、６０分以内とすることが好ましい。すなわち、抗体１を高温雰囲気下で長時間処理した場合には、タンパク質変性を起こすことがあるが、５０℃乃至６５℃の低温雰囲気下で殺菌処理し、殺菌処理の時間を６０分以内とすることでタンパク質変性が生じることを抑制することができる。 In addition, the cosmetic 50 of the present invention is preferably heated and sterilized in a low temperature atmosphere of 50 to 65 ° C. It is preferable to use a manufacturing method that manufactures by The sterilization time is preferably within 60 minutes. That is, when antibody 1 is treated in a high-temperature atmosphere for a long time, protein denaturation may occur, but sterilization is performed in a low-temperature atmosphere of 50 to 65 ° C., and the sterilization time is within 60 minutes. This can suppress the occurrence of protein denaturation.
更に、本発明の化粧品５０は、５００気圧乃至１５００気圧の高圧雰囲気下で加圧され殺菌処理されることが好ましい（化粧品５０の製造は、５００気圧乃至１５００気圧の高圧雰囲気下で加圧され殺菌処理して製造する製造方法により行うことが好ましい）。すなわち、５００気圧乃至１５００気圧の高圧雰囲気下で殺菌処理を行うことで常温雰囲気下での処理が実現できタンパク質変性が生じることを抑制することができる。 Furthermore, the cosmetic 50 of the present invention is preferably pressurized and sterilized in a high-pressure atmosphere of 500 to 1500 atm (the cosmetic 50 is produced by pressurizing and sterilizing in a high-pressure atmosphere of 500 to 1500 atm). It is preferably carried out by a manufacturing method that processes and manufactures). That is, by performing the sterilization treatment in a high-pressure atmosphere of 500 to 1500 atm, the treatment can be performed in a room temperature atmosphere, and protein denaturation can be suppressed.
更にまた、本発明の化粧品５０は、放射線を用いて殺菌処理されることが好ましい（化粧品５０の製造は、放射線を用いて殺菌処理して製造する製造方法により行うことが好ましい）。すなわち、放射線を用いた殺菌処理を行うことで常温雰囲気下での処理が実現できタンパク質変性が生じることを抑制することができる。 Furthermore, the cosmetics 50 of the present invention are preferably sterilized using radiation (the cosmetics 50 are preferably manufactured by a manufacturing method that sterilizes using radiation). That is, by performing a sterilization treatment using radiation, it is possible to realize the treatment in a room temperature atmosphere and suppress the occurrence of protein denaturation.
本発明の化粧品５０にタンパク質変性を抑制する手法として上述した一種以上の天然系原料２の配合、５０℃乃至６５℃の低温雰囲気下での殺菌処理、５００気圧乃至１５００気圧の高圧雰囲気下での殺菌処理、放射線を用いた殺菌処理は、それぞれ単独で行うこととしてもよく、二つ以上を適宜組み合わせることとしてよく、三つ以上を適宜組み合わせることとしてよく、四つ全てを行うこととしてもよい。 As a method for suppressing protein denaturation in the cosmetic product 50 of the present invention, blending of one or more natural raw materials 2 described above, sterilization under a low temperature atmosphere of 50 to 65 ° C., and high pressure atmosphere of 500 to 1500 atmosphere. The sterilization treatment and the sterilization treatment using radiation may each be performed alone, two or more may be appropriately combined, three or more may be appropriately combined, or all four may be performed.
また更に、本発明の化粧品５０は、更にマイナスに帯電したセラミックス等の物質を配合することが好ましい。すなわち、抗原（ウイルス）はマイナスに帯電していることが多く、マイナスに帯電した物質を化粧品５０に配合することで、同じくマイナスに帯電したウイルスを反発させ、ウイルスが皮膚に付着することを抑制することができる。なお、マイナスに帯電した物質は、セラミックスの他各種の物質を用いることができる。 Furthermore, it is preferable that the cosmetic 50 of the present invention further contains a negatively charged substance such as ceramics. That is, antigens (viruses) are often negatively charged, and by adding a negatively charged substance to the cosmetics 50, the negatively charged virus is repelled and the virus is prevented from adhering to the skin. can do. Various substances other than ceramics can be used as the negatively charged substance.
ここで、本発明の化粧品５０は、スプレー状、クリーム状、液状、ゲル状、ペースト状、乳液状、およびムース状の少なくともいずれかであることが好ましい。すなわち、化粧品５０をこのような形態で提供することで、様々な用途に用いることができる。 Here, the cosmetic product 50 of the present invention is preferably in at least one of spray, cream, liquid, gel, paste, emulsion, and mousse. That is, by providing the cosmetic product 50 in such a form, it can be used for various purposes.
なお、スプレー状は、皮膚用スプレーを含むことが好ましく、クリーム状は、皮膚用クリーム、唇用クリーム、鼻腔用クリーム、および目周り（まぶた、目尻、涙袋等）用クリームの少なくともいずれかを含むことが好ましい。 The spray type preferably includes a skin spray, and the cream type includes at least one of skin cream, lip cream, nasal cavity cream, and eye area (eyelid, outer corner of the eye, lacrimal bag, etc.) cream. preferably included.
上記の化粧品５０により、ワクチンや医薬品等で見られる臨床（治験）の必要がなく抗体１を用いてウイルスによるパンデミックへの対応を速やかに行うことができる。 With the cosmetics 50 described above, it is possible to quickly respond to pandemics caused by viruses using the antibody 1 without the need for clinical trials (trials) that are required for vaccines, pharmaceuticals, and the like.
１：抗体
２：天然系原料
１０：飲食品
２０：食品添加物
３０：サプリメント
４０：医薬
５０：化粧品 1: Antibody 2: Natural raw materials 10: Food and drink 20: Food additives 30: Supplements 40: Medicines 50: Cosmetics

Claims (90)

  1. 抗体を配合したことを特徴とする飲食品。 A food or drink characterized by containing an antibody.
  2. 更に殺菌効果を有する天然系原料を配合することを特徴とする請求項１に記載の飲食品。 2. The food or drink according to claim 1, further comprising a natural raw material having a bactericidal effect.
  3. 前記天然系原料は、植物エキスを含むことを特徴とする請求項２に記載の飲食品。 3. The food or drink according to claim 2, wherein the natural raw material contains a plant extract.
  4. 前記植物エキスは、グレープフルーツ抽出エキスまたは茶抽出エキスを含むことを特徴とする請求項３に記載の飲食品。 4. The food or drink according to claim 3, wherein the plant extract contains a grapefruit extract or a tea extract.
  5. 前記グレープフルーツ抽出エキスは、グレープフルーツ種子抽出エキスを含むことを特徴とする請求項４に記載の飲食品。 5. The food or drink according to claim 4, wherein the grapefruit extract contains a grapefruit seed extract.
  6. 前記茶抽出エキスは、茶カテキンを含むことを特徴とする請求項４に記載の飲食品。 5. The food or drink according to claim 4, wherein the tea extract contains tea catechins.
  7. ５０℃乃至６５℃の低温雰囲気下で加熱され殺菌処理されることを特徴とする請求項１に記載の飲食品。 The food or drink according to claim 1, which is sterilized by heating in a low temperature atmosphere of 50°C to 65°C.
  8. 前記殺菌処理の時間は、６０分以内とすることを特徴とする請求項７に記載の飲食品。 8. The food or drink according to claim 7, wherein the sterilization time is within 60 minutes.
  9. ５００気圧乃至１５００気圧の高圧雰囲気下で加圧され殺菌処理されることを特徴とする請求項１に記載の飲食品。 2. The food or drink according to claim 1, which is pressurized and sterilized in a high-pressure atmosphere of 500 to 1500 atm.
  10. 放射線を用いて殺菌処理されることを特徴とする請求項１に記載の飲食品。 The food or drink according to claim 1, wherein the food or drink is sterilized using radiation.
  11. スプレー状、ゼリー状、飴状、カプセル状、タブレット状、丸状、粉末状、顆粒状、細粒状、トローチ状、液状、またはゲル状とすることを特徴とする請求項１乃至請求項１０のいずれか一項に記載の飲食品。 It is in the form of spray, jelly, candy, capsule, tablet, round, powder, granule, fine grain, troche, liquid or gel. Food and drink according to any one of the items.
  12. 前記スプレー状は、口腔内用スプレーの形態とすることを特徴とする請求項１１に記載の飲食品。 12. The food and drink according to claim 11, wherein the spray is in the form of an intraoral spray.
  13. 前記カプセル状は、腸溶カプセルの形態とすることを特徴とする請求項１１に記載の飲食品。 12. The food and drink according to claim 11, wherein the capsule is in the form of an enteric capsule.
  14. 乳製品、発酵食品、およびドリンク類の少なくともいずれかとすることを特徴とする請求項１乃至請求項１３のいずれか一項に記載の飲食品。 14. The food or drink according to any one of claims 1 to 13, characterized by being at least one of dairy products, fermented foods, and drinks.
  15. 前記抗体は、人体外で作製した抗体とすることを特徴とする請求項１乃至請求項１４のいずれか一項に記載の飲食品。 15. The food or drink according to any one of claims 1 to 14, wherein the antibody is an antibody produced outside the human body.
  16. 前記抗体は、ＩｇＹ抗体および／またはＩｇＧ抗体を含むことを特徴とする請求項１５に記載の飲食品。 16. Food and drink according to claim 15, wherein the antibody comprises an IgY antibody and/or an IgG antibody.
  17. 抗体を配合したことを特徴とする食品添加物。 A food additive characterized by containing an antibody.
  18. 更に殺菌効果を有する天然系原料を配合することを特徴とする請求項１７に記載の食品添加物。 18. The food additive according to claim 17, further comprising a natural raw material having a bactericidal effect.
  19. 前記天然系原料は、植物エキスを含むことを特徴とする請求項１８に記載の食品添加物。 19. The food additive according to claim 18, wherein said natural raw material contains a plant extract.
  20. 前記植物エキスは、グレープフルーツ抽出エキスまたは茶抽出エキスを含むことを特徴とする請求項１９に記載の食品添加物。 20. The food additive according to claim 19, wherein the plant extract comprises grapefruit extract or tea extract.
  21. 前記グレープフルーツ抽出エキスは、グレープフルーツ種子抽出エキスを含むことを特徴とする請求項２０に記載の食品添加物。 21. The food additive according to claim 20, wherein said grapefruit extract comprises grapefruit seed extract.
  22. 前記茶抽出エキスは、茶カテキンを含むことを特徴とする請求項２０に記載の食品添加物。 21. The food additive according to claim 20, wherein said tea extract contains tea catechins.
  23. ５０℃乃至６５℃の低温雰囲気下で加熱され殺菌処理されることを特徴とする請求項１７に記載の食品添加物。 The food additive according to claim 17, which is sterilized by heating in a low temperature atmosphere of 50°C to 65°C.
  24. 前記殺菌処理の時間は、６０分以内とすることを特徴とする請求項２３に記載の食品添加物。 24. The food additive according to claim 23, wherein the sterilization time is within 60 minutes.
  25. ５００気圧乃至１５００気圧の高圧雰囲気下で加圧され殺菌処理されることを特徴とする請求項１７に記載の食品添加物。 18. The food additive according to claim 17, which is pressurized and sterilized under a high pressure atmosphere of 500 to 1500 atm.
  26. 放射線を用いて殺菌処理されることを特徴とする請求項１８に記載の食品添加物。 19. Food additive according to claim 18, characterized in that it is sterilized using radiation.
  27. スプレー状、ゼリー状、飴状、カプセル状、タブレット状、丸状、粉末状、顆粒状、細粒状、トローチ状、液状、またはゲル状とすることを特徴とする請求項１７乃至請求項２６のいずれか一項に記載の食品添加物。 It is in the form of spray, jelly, candy, capsule, tablet, round, powder, granule, fine grain, troche, liquid or gel. The food additive according to any one of claims 1 to 3.
  28. 前記スプレー状は、口腔内用スプレーの形態とすることを特徴とする請求項２７に記載の食品添加物。 28. The food additive according to claim 27, wherein said spray is in the form of an intraoral spray.
  29. 前記カプセル状は、腸溶カプセルの形態とすることを特徴とする請求項２７に記載の食品添加物。 28. The food additive according to claim 27, wherein said capsule is in the form of an enteric capsule.
  30. 乳製品、発酵食品、およびドリンク類の少なくともいずれかとすることを特徴とする請求項１７乃至請求項２９のいずれか一項に記載の食品添加物。 30. The food additive according to any one of claims 17 to 29, which is used as at least one of dairy products, fermented foods, and drinks.
  31. 前記抗体は、人体外で作製した抗体とすることを特徴とする請求項１７乃至請求項３０のいずれか一項に記載の食品添加物。 31. The food additive according to any one of claims 17 to 30, wherein said antibody is an antibody produced outside the human body.
  32. 前記抗体は、ＩｇＹ抗体および／またはＩｇＧ抗体を含むことを特徴とする請求項３１に記載の食品添加物。 32. Food additive according to claim 31, characterized in that said antibody comprises an IgY antibody and/or an IgG antibody.
  33. 抗体を配合したことを特徴とするサプリメント。 A supplement characterized by containing an antibody.
  34. 更に殺菌効果を有する天然系原料を配合することを特徴とする請求項３３に記載のサプリメント。 34. The supplement according to claim 33, further comprising a natural raw material having a bactericidal effect.
  35. 前記天然系原料は、植物エキスを含むことを特徴とする請求項３４に記載のサプリメント。 35. The supplement of Claim 34, wherein the natural source material comprises a plant extract.
  36. 前記植物エキスは、グレープフルーツ抽出エキスまたは茶抽出エキスを含むことを特徴とする請求項３５に記載のサプリメント。 36. The supplement of claim 35, wherein the plant extract comprises grapefruit extract or tea extract.
  37. 前記グレープフルーツ抽出エキスは、グレープフルーツ種子抽出エキスを含むことを特徴とする請求項３６に記載のサプリメント。 37. The supplement of claim 36, wherein said grapefruit extract comprises grapefruit seed extract.
  38. 前記茶抽出エキスは、茶カテキンを含むことを特徴とする請求項３７に記載のサプリメント。 38. The supplement according to claim 37, wherein the tea extract comprises tea catechins.
  39. ５０℃乃至６５℃の低温雰囲気下で加熱され殺菌処理されることを特徴とする請求項３３に記載のサプリメント。 34. The supplement according to claim 33, which is sterilized by heating in a low temperature atmosphere of 50°C to 65°C.
  40. 前記殺菌処理の時間は、６０分以内とすることを特徴とする請求項３９に記載のサプリメント。 40. The supplement according to claim 39, wherein the sterilization time is within 60 minutes.
  41. ５００気圧乃至１５００気圧の高圧雰囲気下で加圧され殺菌処理されることを特徴とする請求項３３に記載のサプリメント。 34. The supplement according to claim 33, which is pressurized and sterilized under a high pressure atmosphere of 500 to 1500 atmospheres.
  42. 放射線を用いて殺菌処理されることを特徴とする請求項３３に記載のサプリメント。 34. The supplement of claim 33, wherein the supplement is sterilized using radiation.
  43. スプレー状、ゼリー状、飴状、カプセル状、タブレット状、丸状、粉末状、顆粒状、細粒状、トローチ状、液状、またはゲル状とすることを特徴とする請求項３３乃至請求項４２のいずれか一項に記載のサプリメント。 According to any of claims 33 to 42, it is spray-like, jelly-like, candy-like, capsule-like, tablet-like, round-like, powder-like, granule-like, fine-grain-like, lozenge-like, liquid-like, or gel-like. A supplement according to any one of paragraphs.
  44. 前記スプレー状は、口腔内用スプレーの形態とすることを特徴とする請求項４３に記載のサプリメント。 44. A supplement according to claim 43, wherein said spray is in the form of an oral spray.
  45. 前記カプセル状は、腸溶カプセルの形態とすることを特徴とする請求項４３に記載のサプリメント。 44. The supplement of claim 43, wherein said capsule is in the form of an enteric capsule.
  46. 乳製品、発酵食品、およびドリンク類の少なくともいずれかとすることを特徴とする請求項３３乃至請求項４５のいずれか一項に記載のサプリメント。 46. The supplement according to any one of claims 33 to 45, characterized by being at least one of dairy products, fermented foods, and drinks.
  47. 前記抗体は、人体外で作製した抗体とすることを特徴とする請求項３３乃至請求項４６のいずれか一項に記載のサプリメント。 47. The supplement according to any one of claims 33 to 46, wherein the antibody is an antibody produced outside the human body.
  48. 前記抗体は、ＩｇＹ抗体および／またはＩｇＧ抗体を含むことを特徴とする請求項４７に記載のサプリメント。 48. Supplement according to claim 47, characterized in that said antibodies comprise IgY antibodies and/or IgG antibodies.
  49. 抗体を配合したことを特徴とする化粧品。 A cosmetic characterized by containing an antibody.
  50. 更に殺菌効果を有する天然系原料を配合することを特徴とする請求項４９に記載の化粧品。 50. Cosmetics according to claim 49, characterized by further comprising a natural raw material having a bactericidal effect.
  51. 前記天然系原料は、植物エキスを含むことを特徴とする請求項５０に記載の化粧品。 51. Cosmetics according to claim 50, wherein the natural ingredients comprise plant extracts.
  52. 前記植物エキスは、グレープフルーツ抽出エキスまたは茶抽出エキスを含むことを特徴とする請求項５１に記載の化粧品。 52. Cosmetics according to claim 51, wherein the plant extract comprises grapefruit extract or tea extract.
  53. 前記グレープフルーツ抽出エキスは、グレープフルーツ種子抽出エキスを含むことを特徴とする請求項５２に記載の化粧品。 53. Cosmetics according to claim 52, wherein the grapefruit extract comprises a grapefruit seed extract.
  54. 前記茶抽出エキスは、茶カテキンを含むことを特徴とする請求項５２に記載の化粧品。 53. Cosmetics according to claim 52, wherein the tea extract contains tea catechins.
  55. ５０℃乃至６５℃の低温雰囲気下で加熱され殺菌処理されることを特徴とする請求項４９に記載の化粧品。 50. The cosmetic product according to claim 49, which is sterilized by heating in a low temperature atmosphere of 50 to 65[deg.]C.
  56. 前記殺菌処理の時間は、６０分以内とすることを特徴とする請求項５５に記載の化粧品。 56. Cosmetics according to claim 55, characterized in that the sterilization time is within 60 minutes.
  57. ５００気圧乃至１５００気圧の高圧雰囲気下で加圧され殺菌処理されることを特徴とする請求項４９に記載の化粧品。 50. Cosmetics according to claim 49, characterized by being pressurized and sterilized under a high pressure atmosphere of 500 to 1500 atmospheres.
  58. 放射線を用いて殺菌処理されることを特徴とする請求項４９に記載の化粧品。 50. Cosmetics according to claim 49, characterized in that they are sterilized using radiation.
  59. 更にマイナスに帯電した物質を配合することを特徴とする請求項４９乃至請求項５８のいずれか一項に記載の化粧品。 59. Cosmetics according to any one of claims 49 to 58, further comprising a negatively charged substance.
  60. スプレー状、クリーム状、液状、ゲル状、ペースト状、乳液状、およびムース状の少なくともいずれかであることを特徴とする請求項４９乃至請求項５９のいずれか一項に記載の化粧品。 60. The cosmetic product according to any one of claims 49 to 59, which is in at least one of spray, cream, liquid, gel, paste, emulsion, and mousse.
  61. 前記スプレー状は、皮膚用スプレーを含むことを特徴とする請求項６０に記載の化粧品。 61. A cosmetic product according to Claim 60, wherein said spray comprises a skin spray.
  62. 前記クリーム状は、皮膚用クリーム、唇用クリーム、鼻腔用クリーム、および目周り用クリームの少なくともいずれかを含むことを特徴とする請求項６０に記載の化粧品。 61. A cosmetic product according to claim 60, wherein said cream comprises at least one of skin cream, lip cream, nasal cream and eye cream.
  63. 前記抗体は、人体外で作製した抗体とすることを特徴とする請求項４９乃至請求項６２のいずれか一項に記載の化粧品。 63. The cosmetic product according to any one of claims 49 to 62, wherein the antibody is an antibody produced outside the human body.
  64. 前記抗体は、ＩｇＹ抗体および／またはＩｇＧ抗体を含むことを特徴とする請求項６３に記載の化粧品。 64. Cosmetics according to claim 63, characterized in that said antibodies comprise IgY antibodies and/or IgG antibodies.
  65. 人体外で作製したことを特徴とする抗体。 An antibody characterized by being produced outside the human body.
  66. ＩｇＹ抗体および／またはＩｇＧ抗体を含むことを特徴とする請求項６５に記載の抗体。 66. Antibody according to claim 65, characterized in that it comprises an IgY antibody and/or an IgG antibody.
  67. 抗体を配合したことを特徴とする医薬。 A medicine characterized by containing an antibody.
  68. 更に殺菌効果を有する天然系原料を配合することを特徴とする請求項６７に記載の医薬。 68. The pharmaceutical according to claim 67, further comprising a natural raw material having a bactericidal effect.
  69. 前記天然系原料は、植物エキスを含むことを特徴とする請求項６８に記載の医薬。 69. The medicament according to claim 68, wherein said natural source material comprises a plant extract.
  70. 前記植物エキスは、グレープフルーツ抽出エキスまたは茶抽出エキスを含むことを特徴とする請求項６９に記載の医薬。 70. The medicament according to claim 69, wherein the plant extract comprises grapefruit extract or tea extract.
  71. 前記グレープフルーツ抽出エキスは、グレープフルーツ種子抽出エキスを含むことを特徴とする請求項７０に記載の医薬。 71. The medicament according to claim 70, wherein said grapefruit extract comprises grapefruit seed extract.
  72. 前記茶抽出エキスは、茶カテキンを含むことを特徴とする請求項７０に記載の医薬。 71. The pharmaceutical according to claim 70, wherein the tea extract contains tea catechins.
  73. ５０℃乃至６５℃の低温雰囲気下で加熱され殺菌処理されることを特徴とする請求項６７に記載の医薬。 The pharmaceutical according to claim 67, which is sterilized by heating in a low temperature atmosphere of 50°C to 65°C.
  74. 前記殺菌処理の時間は、６０分以内とすることを特徴とする請求項７３に記載の医薬。 74. The pharmaceutical according to claim 73, wherein the sterilization time is within 60 minutes.
  75. ５００気圧乃至１５００気圧の高圧雰囲気下で加圧され殺菌処理されることを特徴とする請求項６７に記載の医薬。 68. The medicament according to claim 67, which is pressurized and sterilized under a high pressure atmosphere of 500 to 1500 atm.
  76. 放射線を用いて殺菌処理されることを特徴とする請求項６７に記載の医薬。 68. A medicament according to claim 67, characterized in that it is sterilized using radiation.
  77. スプレー状、ゼリー状、飴状、カプセル状、タブレット状、丸状、粉末状、顆粒状、細粒状、トローチ状、液状、またはゲル状とすることを特徴とする請求項６７乃至請求項７６のいずれか一項に記載の医薬。 According to claims 67 to 76, it is in the form of spray, jelly, candy, capsule, tablet, round, powder, granule, fine granule, lozenge, liquid or gel. A medicament according to any one of the clauses.
  78. 前記スプレー状は、口腔内用スプレーの形態とすることを特徴とする請求項７７に記載の医薬。 78. The medicament according to claim 77, wherein said spray is in the form of an intraoral spray.
  79. 前記カプセル状は、腸溶カプセルの形態とすることを特徴とする請求項７７に記載の医薬。 78. The medicament according to claim 77, wherein said capsule is in the form of an enteric capsule.
  80. 乳製品、発酵食品、およびドリンク類の少なくともいずれかとすることを特徴とする請求項６７乃至請求項７９のいずれか一項に記載の医薬。 80. The pharmaceutical according to any one of claims 67 to 79, characterized by being at least one of dairy products, fermented foods, and drinks.
  81. 前記抗体は、人体外で作製したことを特徴とする請求項６７に記載の医薬。 68. The medicament according to claim 67, wherein said antibody is produced outside the human body.
  82. 前記抗体は、ＩｇＹ抗体および／またはＩｇＧ抗体を含むことを特徴とする請求項６７に記載の医薬。 68. A medicament according to claim 67, characterized in that said antibody comprises an IgY antibody and/or an IgG antibody.
  83. 対象の感染症を予防および／または治療するために用いることを特徴とする請求項６７に記載の医薬。 68. The medicament according to claim 67, which is used for preventing and/or treating an infectious disease in a subject.
  84. 前記感染症は、コロナウイルス、インフルエンザ、ＳＡＲＳ、およびＭＡＲＳから構成される群から選ばれる１種または複数の感染症を含むことを特徴とする請求項８３に記載の医薬。 84. The medicament according to claim 83, wherein the infectious disease comprises one or more infectious diseases selected from the group consisting of coronavirus, influenza, SARS, and MARS.
  85. 前記対象は、哺乳類とすることを特徴とする請求項８３に記載の医薬。 84. The medicament of claim 83, wherein said subject is a mammal.
  86. 前記哺乳類は、ヒトとすることを特徴とする請求項８５に記載の医薬。 86. A medicament according to claim 85, wherein said mammal is a human.
  87. 抗体、抗体を配合した飲食品、食品添加物、サプリメント、化粧品、および医薬の少なくともいずれかを５０℃乃至６５℃の低温雰囲気下で加熱し殺菌処理して製造することを特徴とする製造方法。 A manufacturing method characterized by heating and sterilizing at least one of an antibody, an antibody-blended food and drink, a food additive, a supplement, a cosmetic, and a drug in a low-temperature atmosphere of 50°C to 65°C.
  88. 前記殺菌処理の時間は、６０分以内とすることを特徴とする請求項８７に記載の製造方法。 88. The manufacturing method according to claim 87, wherein the sterilization time is within 60 minutes.
  89. ５００気圧乃至１５００気圧の高圧雰囲気下で加圧され殺菌処理して製造することを特徴とする請求項８７に記載の製造方法。 88. The production method according to claim 87, wherein the production is performed by pressurization and sterilization under a high pressure atmosphere of 500 to 1500 atmospheres.
  90. 抗体、抗体を配合した飲食品、食品添加物、サプリメント、化粧品、および医薬の少なくともいずれかを放射線を用いて殺菌処理して製造することを特徴とする請求項８７に記載の製造方法。
          88. The production method according to claim 87, wherein at least one of antibodies, antibody-blended foods and drinks, food additives, supplements, cosmetics, and pharmaceuticals is produced by sterilizing with radiation.
PCT/JP2022/038816 2021-10-21 2022-10-18 Food or drink, food additive, supplement, cosmetic, antibody, drug, and manufacturing method therefor WO2023068282A1 (en)

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