WO2023051701A1 - Arnm, protéine et vaccin contre l'infection par sars-cov-2 - Google Patents
Arnm, protéine et vaccin contre l'infection par sars-cov-2 Download PDFInfo
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
L'invention concerne un ARNm agissant contre l'infection par le SARS-CoV-2. L'ADN gabarit de l'ARNm comprend une région de codage d'antigène. La région de codage d'antigène code une protéine S exempte de peptide signal d'un mutant Delta du SARS-CoV-2, la protéine S du mutant Delta présentant au moins l'une des mutations K986P et V987P ; la région de codage d'antigène code un domaine NTD_RBD d'un mutant Delta du SARS-CoV-2, le domaine NTD_RBD du mutant Delta ayant une mutation C538S ; la région de codage d'antigène code un domaine RBD d'un mutant Delta du SARS-CoV-2 et/ou un domaine NTD_RBD d'un mutant Gamma du SARS-CoV-2, le domaine RBD du mutant Delta du SARS-CoV-2 présentant une mutation C538S, et le domaine NTD_RBD du mutant Gamma du SARS-CoV-2 présentant une mutation D80A, une mutation R246I et une mutation C538S, et présentant Δ242-244 d'un mutant Bêta ajouté à celui-ci ; ou la région de codage d'antigène code un domaine RBD de la protéine S d'un mutant Delta de SARS-CoV-2, un domaine RBD de la protéine S d'un mutant Bêta du SARS-CoV-2, un domaine RBD de la protéine S d'un mutant Gamma du SARS-CoV-2 et un domaine RBD de la protéine S du SARS-CoV-2 de type sauvage.
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