WO2023032872A1 - 単環ピリジン誘導体の合成中間体の製造方法 - Google Patents
単環ピリジン誘導体の合成中間体の製造方法 Download PDFInfo
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- WO2023032872A1 WO2023032872A1 PCT/JP2022/032309 JP2022032309W WO2023032872A1 WO 2023032872 A1 WO2023032872 A1 WO 2023032872A1 JP 2022032309 W JP2022032309 W JP 2022032309W WO 2023032872 A1 WO2023032872 A1 WO 2023032872A1
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 51
- -1 monocyclic pyridine derivative Chemical class 0.000 title claims description 45
- 150000001875 compounds Chemical class 0.000 claims abstract description 149
- 150000003839 salts Chemical class 0.000 claims abstract description 23
- 238000006243 chemical reaction Methods 0.000 claims description 53
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 11
- YYROPELSRYBVMQ-UHFFFAOYSA-N 4-toluenesulfonyl chloride Chemical group CC1=CC=C(S(Cl)(=O)=O)C=C1 YYROPELSRYBVMQ-UHFFFAOYSA-N 0.000 claims description 10
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 9
- 125000006239 protecting group Chemical group 0.000 claims description 8
- 125000005843 halogen group Chemical group 0.000 claims description 7
- 229940049964 oleate Drugs 0.000 claims description 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 6
- QIJIUJYANDSEKG-UHFFFAOYSA-N 2,4,4-trimethylpentan-2-amine Chemical compound CC(C)(C)CC(C)(C)N QIJIUJYANDSEKG-UHFFFAOYSA-N 0.000 claims description 6
- 125000003118 aryl group Chemical group 0.000 claims description 6
- 239000003054 catalyst Substances 0.000 claims description 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 6
- VEDDBHYQWFOITD-UHFFFAOYSA-N para-bromobenzyl alcohol Chemical compound OCC1=CC=C(Br)C=C1 VEDDBHYQWFOITD-UHFFFAOYSA-N 0.000 claims description 5
- KDFDOINBXBEOLZ-UHFFFAOYSA-N 2-phenylpropan-2-amine Chemical compound CC(C)(N)C1=CC=CC=C1 KDFDOINBXBEOLZ-UHFFFAOYSA-N 0.000 claims description 4
- 125000006281 4-bromobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Br)C([H])([H])* 0.000 claims description 4
- SNWQAKNKGGOVMO-UHFFFAOYSA-N 5-nitro-1,3-benzodioxole Chemical compound [O-][N+](=O)C1=CC=C2OCOC2=C1 SNWQAKNKGGOVMO-UHFFFAOYSA-N 0.000 claims description 4
- 125000003277 amino group Chemical group 0.000 claims description 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 125000001424 substituent group Chemical group 0.000 claims description 4
- 239000012190 activator Substances 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 3
- 238000006798 ring closing metathesis reaction Methods 0.000 claims description 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 3
- 229910052763 palladium Inorganic materials 0.000 claims description 2
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
- 239000000543 intermediate Substances 0.000 abstract description 6
- 230000015572 biosynthetic process Effects 0.000 abstract description 4
- 238000003786 synthesis reaction Methods 0.000 abstract description 4
- 229940125829 fibroblast growth factor receptor inhibitor Drugs 0.000 abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 63
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 54
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- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 54
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 51
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- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 36
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 36
- 239000012044 organic layer Substances 0.000 description 34
- 239000000203 mixture Substances 0.000 description 32
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- 239000007858 starting material Substances 0.000 description 22
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 20
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- 239000002904 solvent Substances 0.000 description 20
- 239000013078 crystal Substances 0.000 description 19
- 235000011121 sodium hydroxide Nutrition 0.000 description 18
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 17
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 16
- MFRIHAYPQRLWNB-UHFFFAOYSA-N sodium tert-butoxide Chemical compound [Na+].CC(C)(C)[O-] MFRIHAYPQRLWNB-UHFFFAOYSA-N 0.000 description 16
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 15
- 239000012046 mixed solvent Substances 0.000 description 13
- 229910000027 potassium carbonate Inorganic materials 0.000 description 13
- 235000011181 potassium carbonates Nutrition 0.000 description 13
- 239000003153 chemical reaction reagent Substances 0.000 description 12
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- 229940011051 isopropyl acetate Drugs 0.000 description 12
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 12
- 239000000725 suspension Substances 0.000 description 12
- DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 12
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 11
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- 238000001816 cooling Methods 0.000 description 10
- 239000012299 nitrogen atmosphere Substances 0.000 description 10
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 10
- 239000011780 sodium chloride Substances 0.000 description 10
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 9
- 239000012141 concentrate Substances 0.000 description 8
- 239000010410 layer Substances 0.000 description 8
- 235000011118 potassium hydroxide Nutrition 0.000 description 8
- FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 description 7
- 229910000024 caesium carbonate Inorganic materials 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- BQOBJLNBHDFAOW-UHFFFAOYSA-N 6-(2-methoxyethoxy)-1h-indol-5-ol Chemical compound C1=C(O)C(OCCOC)=CC2=C1C=CN2 BQOBJLNBHDFAOW-UHFFFAOYSA-N 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- 229940098779 methanesulfonic acid Drugs 0.000 description 5
- 238000000926 separation method Methods 0.000 description 5
- 229910000029 sodium carbonate Inorganic materials 0.000 description 5
- 235000017550 sodium carbonate Nutrition 0.000 description 5
- CYSGHNMQYZDMIA-UHFFFAOYSA-N 1,3-Dimethyl-2-imidazolidinon Chemical compound CN1CCN(C)C1=O CYSGHNMQYZDMIA-UHFFFAOYSA-N 0.000 description 4
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- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 4
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- 230000003213 activating effect Effects 0.000 description 4
- 238000010511 deprotection reaction Methods 0.000 description 4
- CQILOHWHIWNQOE-UHFFFAOYSA-N indole-1-carboxamide Chemical compound C1=CC=C2N(C(=O)N)C=CC2=C1 CQILOHWHIWNQOE-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- SCWKRWCUMCMVPW-UHFFFAOYSA-N phenyl n-methylcarbamate Chemical compound CNC(=O)OC1=CC=CC=C1 SCWKRWCUMCMVPW-UHFFFAOYSA-N 0.000 description 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 4
- 239000012312 sodium hydride Substances 0.000 description 4
- 229910000104 sodium hydride Inorganic materials 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 4
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- 229960000549 4-dimethylaminophenol Drugs 0.000 description 3
- OVRKATYHWPCGPZ-UHFFFAOYSA-N 4-methyloxane Chemical compound CC1CCOCC1 OVRKATYHWPCGPZ-UHFFFAOYSA-N 0.000 description 3
- CJVDKOCUYKKXCW-UHFFFAOYSA-N 5-(2-aminopyridin-4-yl)oxy-6-(2-methoxyethoxy)-n-methylindole-1-carboxamide Chemical compound COCCOC=1C=C2N(C(=O)NC)C=CC2=CC=1OC1=CC=NC(N)=C1 CJVDKOCUYKKXCW-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
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- MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical compound C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 2
- 150000007942 carboxylates Chemical class 0.000 description 2
- 239000007810 chemical reaction solvent Substances 0.000 description 2
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- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 description 1
- VLLSCJFPVSQXDM-UHFFFAOYSA-N 2-phenoxyacetonitrile Chemical compound N#CCOC1=CC=CC=C1 VLLSCJFPVSQXDM-UHFFFAOYSA-N 0.000 description 1
- PCYGLFXKCBFGPC-UHFFFAOYSA-N 3,4-Dihydroxy hydroxymethyl benzene Natural products OCC1=CC=C(O)C(O)=C1 PCYGLFXKCBFGPC-UHFFFAOYSA-N 0.000 description 1
- YLZOPXRUQYQQID-UHFFFAOYSA-N 3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]propan-1-one Chemical compound N1N=NC=2CN(CCC=21)CCC(=O)N1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F YLZOPXRUQYQQID-UHFFFAOYSA-N 0.000 description 1
- WADSJYLPJPTMLN-UHFFFAOYSA-N 3-(cycloundecen-1-yl)-1,2-diazacycloundec-2-ene Chemical compound C1CCCCCCCCC=C1C1=NNCCCCCCCC1 WADSJYLPJPTMLN-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- PVMNPAUTCMBOMO-UHFFFAOYSA-N 4-chloropyridine Chemical compound ClC1=CC=NC=C1 PVMNPAUTCMBOMO-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- RENMDAKOXSCIGH-UHFFFAOYSA-N Chloroacetonitrile Chemical compound ClCC#N RENMDAKOXSCIGH-UHFFFAOYSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical class F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 238000005481 NMR spectroscopy Methods 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 238000010306 acid treatment Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 238000005937 allylation reaction Methods 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 229940009098 aspartate Drugs 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-L aspartate group Chemical class N[C@@H](CC(=O)[O-])C(=O)[O-] CKLJMWTZIZZHCS-REOHCLBHSA-L 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 1
- 229940077388 benzenesulfonate Drugs 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical class OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 description 1
- CSKNSYBAZOQPLR-UHFFFAOYSA-N benzenesulfonyl chloride Chemical compound ClS(=O)(=O)C1=CC=CC=C1 CSKNSYBAZOQPLR-UHFFFAOYSA-N 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 208000006990 cholangiocarcinoma Diseases 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- DLUXOICIYRXRNK-UHFFFAOYSA-M cyanomethyl(trimethyl)azanium;iodide Chemical compound [I-].C[N+](C)(C)CC#N DLUXOICIYRXRNK-UHFFFAOYSA-M 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-N ethanesulfonic acid Chemical class CCS(O)(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-N 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 150000002306 glutamic acid derivatives Chemical class 0.000 description 1
- 150000005363 heterobiaryls Chemical group 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 229910000042 hydrogen bromide Inorganic materials 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 201000007450 intrahepatic cholangiocarcinoma Diseases 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- YNESATAKKCNGOF-UHFFFAOYSA-N lithium bis(trimethylsilyl)amide Chemical compound [Li+].C[Si](C)(C)[N-][Si](C)(C)C YNESATAKKCNGOF-UHFFFAOYSA-N 0.000 description 1
- XGZVUEUWXADBQD-UHFFFAOYSA-L lithium carbonate Chemical compound [Li+].[Li+].[O-]C([O-])=O XGZVUEUWXADBQD-UHFFFAOYSA-L 0.000 description 1
- 229910052808 lithium carbonate Inorganic materials 0.000 description 1
- SIAPCJWMELPYOE-UHFFFAOYSA-N lithium hydride Chemical compound [LiH] SIAPCJWMELPYOE-UHFFFAOYSA-N 0.000 description 1
- 229910000103 lithium hydride Inorganic materials 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- UKVIEHSSVKSQBA-UHFFFAOYSA-N methane;palladium Chemical compound C.[Pd] UKVIEHSSVKSQBA-UHFFFAOYSA-N 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-M methanesulfonate group Chemical class CS(=O)(=O)[O-] AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 description 1
- SKTCDJAMAYNROS-UHFFFAOYSA-N methoxycyclopentane Chemical compound COC1CCCC1 SKTCDJAMAYNROS-UHFFFAOYSA-N 0.000 description 1
- SURZCVYFPAXNGN-UHFFFAOYSA-N methyl-carbamic acid ethyl ester Chemical compound CCOC(=O)NC SURZCVYFPAXNGN-UHFFFAOYSA-N 0.000 description 1
- DVSDBMFJEQPWNO-UHFFFAOYSA-N methyllithium Chemical compound C[Li] DVSDBMFJEQPWNO-UHFFFAOYSA-N 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
- OFYOLZSDWXUNJV-UHFFFAOYSA-N n-methylcarbamoyl bromide Chemical compound CNC(Br)=O OFYOLZSDWXUNJV-UHFFFAOYSA-N 0.000 description 1
- GRRYSIXDUIAUGY-UHFFFAOYSA-N n-methylcarbamoyl chloride Chemical compound CNC(Cl)=O GRRYSIXDUIAUGY-UHFFFAOYSA-N 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- DASJFYAPNPUBGG-UHFFFAOYSA-N naphthalene-1-sulfonyl chloride Chemical compound C1=CC=C2C(S(=O)(=O)Cl)=CC=CC2=C1 DASJFYAPNPUBGG-UHFFFAOYSA-N 0.000 description 1
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 1
- 125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 229910003446 platinum oxide Inorganic materials 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- IUBQJLUDMLPAGT-UHFFFAOYSA-N potassium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([K])[Si](C)(C)C IUBQJLUDMLPAGT-UHFFFAOYSA-N 0.000 description 1
- NTTOTNSKUYCDAV-UHFFFAOYSA-N potassium hydride Chemical compound [KH] NTTOTNSKUYCDAV-UHFFFAOYSA-N 0.000 description 1
- 229910000105 potassium hydride Inorganic materials 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 229940086066 potassium hydrogencarbonate Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 150000003222 pyridines Chemical class 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 229930195734 saturated hydrocarbon Natural products 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- WRIKHQLVHPKCJU-UHFFFAOYSA-N sodium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([Na])[Si](C)(C)C WRIKHQLVHPKCJU-UHFFFAOYSA-N 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- UJJDEOLXODWCGK-UHFFFAOYSA-N tert-butyl carbonochloridate Chemical compound CC(C)(C)OC(Cl)=O UJJDEOLXODWCGK-UHFFFAOYSA-N 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- 125000002827 triflate group Chemical class FC(S(=O)(=O)O*)(F)F 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Definitions
- the present invention relates to a method for producing synthetic intermediates of monocyclic pyridine derivatives useful as FGFR inhibitors.
- E7090 5-((2-(4-(1-(2-hydroxyethyl)piperidin-4-yl)benzamido)pyridin-4-yl)oxy)-6-(2-methoxyethoxy)- which is a monocyclic pyridine derivative N-methyl-1H-indole-1-carboxamidobutanedioate (2:3) (hereinafter also referred to as "E7090") has a strong FGFR (fibroblast growth factor receptor) inhibitory action, and is useful as a therapeutic agent for intrahepatic cholangiocarcinoma, breast cancer, etc., in which FGFR kinase is involved.
- FGFR fibroblast growth factor receptor
- Patent Document 1 Examples 20, 22, etc.
- Patent Document 2 Example 1, etc.
- the purpose of the present application is to provide a production method that enables the synthesis of a key intermediate for producing E7090, which is useful as an FGFR inhibitor, in a higher yield and with better work efficiency.
- Step 2-b 2-c) Compound (2c) and Compound (2d) Obtained in Step 2-b) (wherein R 1 means a tert-pentyl group, a tert-butyl group, a tert-octyl group or a cumyl group) in the presence of an activator to give compound (2e).
- C 1-6 alkyl group refers to a monovalent group derived by removing any one hydrogen atom from an aliphatic saturated hydrocarbon having 1 to 6 carbon atoms, means 1 to 6 linear or branched substituents.
- Examples of C 1-6 alkyl groups include methyl group, ethyl group, 1-propyl group, 2-propyl group, 2-methyl-1-propyl group, 2-methyl-2-propyl group, 1-butyl group, 2-butyl group, 1-pentyl group, 2-pentyl group, 3-pentyl group, 1-hexyl group, 2-hexyl group, 3-hexyl group, preferably methyl group, ethyl is the base.
- C 6-10 aryl group means an aromatic cyclic hydrocarbon group having 6 to 10 carbon atoms.
- the C 6-10 aryl group includes, for example, a phenyl group, a 1-naphthyl group and a 2-naphthyl group, preferably a phenyl group.
- Halogen atom as used herein means a fluorine atom, a chlorine atom, a bromine atom or an iodine atom, preferably a chlorine atom or a bromine atom.
- the “base” includes, for example, lithium hydroxide, sodium hydroxide, potassium hydroxide, lithium carbonate, sodium carbonate, potassium carbonate, potassium tert-butoxide, sodium tert-butoxide, sodium hydrogen carbonate, potassium hydrogen carbonate.
- inorganic bases such as cesium carbonate
- organic metal reagents such as butyllithium, methyllithium, lithium bistrimethylsilylamide, sodium bistrimethylsilylamide, potassium bistrimethylsilylamide
- hydrides such as lithium hydride, sodium hydride, potassium hydride
- imidazole pyridine, dimethylpyridine, trimethylpyridine and 4-dimethylaminopyridine
- organic amines such as triethylamine, N,N-diisopropylethylamine and diazabicycloundecene.
- the term "compound” includes anhydrides, hydrates, and solvates.
- salt includes, for example, inorganic acid salts (sulfates, nitrates, perchlorates, phosphates, carbonates, bicarbonates, hydrofluorides, hydrochlorides, hydrogen bromide acid salts, and hydroiodes), organic carboxylates (such as acetates, oxalates, maleates, fumarates, succinates, tartrates, and citrates), organic sulfonates (methanesulfonate, trifluoromethanesulfonate, ethanesulfonate, benzenesulfonate, toluenesulfonate, and camphorsulfonate, etc.), salts with acidic amino acids (aspartate, glutamate, etc.) etc.
- inorganic acid salts sulfates, nitrates, perchlorates, phosphates, carbonates, bicarbonates, hydrofluorides, hydrochlorides, hydrogen bromide acid salts,
- the salt of compound (2i) is not particularly limited, and examples thereof include salts with inorganic acids, salts with organic acids, and salts with acidic amino acids.
- step 1-a 1,2-(methylenedioxy)-4-nitrobenzene (compound (1a)) and 4-bromobenzyl alcohol (compound (1b)) are reacted in the presence of a base to give compound (1c ) is obtained.
- 4-bromobenzyl alcohol may be used in an amount of 1.0 to 2.0 equivalents relative to compound (1a). Preferably, it is from 1.1 equivalents to 1.3 equivalents.
- the base may be potassium hydroxide, sodium hydroxide, potassium carbonate, sodium carbonate, cesium carbonate, potassium tert-butoxide, sodium tert-butoxide and sodium hydride. Sodium tert-butoxide is preferred.
- a base may be used in an amount of 1.0 to 5.0 equivalents relative to compound (1a). Preferably, it is 1.0 to 3.0 equivalents.
- the solvent is not particularly limited as long as it dissolves the starting material and does not inhibit the reaction.
- Examples include N,N-dimethylformamide, dimethylsulfoxide, N,N-dimethylacetamide, 1,3 -dimethyl-2-imidazolidinone, tetrahydrofuran, or a mixed solvent thereof.
- Preferred is a mixed solvent of dimethylsulfoxide and tetrahydrofuran.
- the reaction temperature usually varies depending on the starting material, solvent, and other reagents used in the reaction, and may range from 0°C to 30°C. Preferably, it is 5°C to 20°C.
- Step 1-b) is a step of reacting compound (1c) with a methoxyethylating agent in the presence of a base to obtain compound (1d).
- the methoxyethylating agent may be, for example, 2-chloroethyl methyl ether, 2-bromoethyl methyl ether, or 2-iodoethyl methyl ether. 2-bromoethyl methyl ether is preferred.
- the methoxyethylating agent may be used in an amount of 1.0 to 2.0 equivalents relative to compound (1c). Preferably, it is 1.0 to 1.2 equivalents.
- the base may be potassium hydroxide, sodium hydroxide, potassium carbonate, sodium carbonate, cesium carbonate, potassium tert-butoxide, sodium tert-butoxide and sodium hydride. Potassium carbonate is preferred.
- a base may be used in an amount of 1.0 to 5.0 equivalents relative to compound (1d). Preferably, it is from 1.1 equivalents to 1.3 equivalents.
- the solvent is not particularly limited as long as it dissolves the starting material and does not inhibit the reaction.
- examples include N,N-dimethylformamide, dimethylsulfoxide, N,N-dimethylacetamide, 1,3 -dimethyl-2-imidazolidinone. N,N-dimethylformamide is preferred.
- the reaction temperature usually varies depending on the starting material, solvent, and other reagents used in the reaction, and may range from room temperature to 80°C. Preferably, it is 40°C to 70°C.
- Step 1-c) is a step of reacting compound (1d) with a cyanomethylating agent in the presence of a base to obtain compound (1f).
- the cyanomethylating agent may be, for example, 4-chlorophenoxyacetonitrile, 4-bromophenoxyacetonitrile, phenoxyacetonitrile, 2-chloroacetonitrile, 2-bromoacetonitrile, 2-iodoacetonitrile, (cyanomethyl)trimethylammonium iodide. .
- 4-chlorophenoxyacetonitrile may be used in an amount of 1.0 to 2.0 equivalents relative to compound (1d). Preferably, it is from 1.2 equivalents to 1.4 equivalents.
- the base may be potassium hydroxide, sodium hydroxide, potassium carbonate, sodium carbonate, cesium carbonate, potassium tert-butoxide, sodium tert-butoxide and sodium hydride. Potassium tert-butoxide is preferred.
- a base may be used in an amount of 1.0 to 5.0 equivalents relative to compound (1d). Preferably, it is 2.0 equivalents to 4.0 equivalents.
- the solvent is not particularly limited as long as it dissolves the starting material and does not inhibit the reaction.
- examples include N,N-dimethylformamide, dimethylsulfoxide, N,N-dimethylacetamide, 1,3 -dimethyl-2-imidazolidinone. N,N-dimethylformamide is preferred.
- the reaction temperature usually varies depending on the starting material, solvent, and other reagents used in the reaction, and may be -70°C to room temperature. Preferably, it is -70°C to -50°C.
- Step 1-d) is the conversion of the nitro group in compound (1f) to an amino group, removal of the 4-bromobenzyl group, and acid-catalyzed ring closure to give compound (1g).
- a reduction catalyst may be used under a hydrogen atmosphere for the conversion of the nitro group to the amino group and the removal of the 4-bromobenzyl group.
- reduction catalysts include palladium carbon, palladium black, and platinum oxide. Preference is given to using palladium on carbon under a hydrogen atmosphere.
- the reaction solvent is not particularly limited as long as it dissolves the starting material and does not inhibit the reaction.
- Examples include tetrahydrofuran, methanol, ethanol, water, or mixed solvents thereof, tetrahydrofuran and water, May be methanol, tetrahydrofuran and ethanol.
- Preferred is a mixed solvent of tetrahydrofuran and water.
- the acid catalyst may be hydrochloric acid, sulfuric acid, or acetic acid. Sulfuric acid is preferred.
- concentration of acid catalyst used may be from 0.01N to 1.0N. Preferably, it is 0.01N to 0.2N.
- the reaction temperature usually varies depending on the starting material, solvent, and other reagents used in the reaction, and may range from room temperature to 60°C. Preferably, it is 30°C to 50°C.
- Step 2-a) is a step of introducing a protecting group into compound (1g) to obtain compound (2a).
- the protective group to be introduced may be a tert-butoxycarbonyl group, a benzyloxycarbonyl group, a benzoyl group, an acetyl group, or a trifluoroacetyl group.
- a tert-butoxycarbonyl group is preferred.
- di-tert-butyl-dicarbonate and tert-butoxycarbonyl chloride may be used.
- Di-tert-butyl-dicarbonate is preferred.
- Di-tert-butyl-dicarbonate may be used in an amount of 1 to 5 equivalents relative to compound (1 g). Preferably, it is 2.0 equivalents to 2.5 equivalents.
- N,N-dimethylaminopyridine When di-tert-butyl-dicarbonate is used, triethylamine, N-methylimidazole, N,N-dimethylaminopyridine (DMAP) may be used as a base. N,N-dimethylaminopyridine (DMAP) is preferred. When di-tert-butyl-dicarbonate is used, N,N-dimethylaminopyridine (DMAP) may be used in an amount of 0.01 to 2.0 equivalents relative to compound (1 g). Preferably, it is 0.05 to 0.2 equivalents.
- the solvent is not particularly limited as long as it dissolves the starting material and does not inhibit the reaction.
- tetrahydrofuran N,N-dimethylformamide, acetonitrile, and ethyl acetate may be used. Tetrahydrofuran is preferred.
- the reaction temperature usually varies depending on the starting material, solvent, and other reagents used in the reaction, and may range from 0°C to 60°C. Preferably, it is 20°C to 30°C.
- step 2-a) selective deprotection of hydroxyl groups may be performed, and deprotection can be performed under appropriate conditions depending on the protecting group.
- a tert-butoxycarbonyl group and a benzyloxycarbonyl group can be easily hydrolyzed under hydrolysis conditions.
- sodium hydroxide, potassium hydroxide, sodium carbonate, and potassium carbonate may be used as the base.
- Potassium carbonate is preferred. Potassium carbonate may be used in an amount of 0.7 to 1.2 equivalents relative to compound (1 g). Preferably, it is 0.7 equivalents to 0.9 equivalents.
- the solvent is not particularly limited as long as it dissolves the starting material and does not inhibit the reaction.
- it may be methanol, ethanol, isopropyl alcohol, acetonitrile, water, or a mixed solvent thereof. Methanol is preferred.
- the reaction temperature usually varies depending on the starting material, solvent, and other reagents used in the reaction, and may be 25°C to 50°C. Preferably, it is 30°C to 40°C.
- Step 2-b) is a step of reacting compound (2a) and compound (2b) in the presence of a base to obtain compound (2c).
- the compound (2b) may be 4-chloropyridin-1-ium-oleate, 4-bromopyridin-1-ium-oleate, and 4-nitropyridin-1-ium-oleate. Preferred is 4-nitropyridin-1-ium-oleate.
- Compound (2b) can be used in an amount of 1.0 to 1.4 equivalents relative to compound (2a). Preferably, it is from 1.1 equivalents to 1.3 equivalents.
- the base may be potassium carbonate, cesium carbonate, potassium tert-butoxide, or 48% potassium hydroxide aqueous solution. Cesium carbonate is preferred.
- the base can be used in an amount of 1 to 3 equivalents relative to compound (2a). Preferably, it is from 1.4 equivalents to 1.6 equivalents.
- the solvent is not particularly limited as long as it dissolves the starting material and does not inhibit the reaction.
- examples include N,N-dimethylformamide, N,N-dimethylacetamide, dimethylsulfoxide, It may be dimethyl-2-imidazolidinone. Dimethyl sulfoxide is preferred.
- the reaction temperature usually varies depending on the starting material, solvent, and other reagents used in the reaction, and may range from 0°C to 60°C. Preferably, it is from 30°C to 50°C.
- Step 2-c) is a step of reacting compound (2c) and compound (2d) in the presence of an activating agent to obtain compound (2e).
- the compound (2d) may be, for example, tert-butylamine, tert-pentylamine, cumylamine, or tert-octylamine. Preferred is tert-octylamine.
- Compound (2d) can be used in an amount of 1 to 15 equivalents relative to compound (2c). It is preferably 5 to 10 equivalents.
- Activating agents include p-toluenesulfonyl chloride, benzenesulfonyl chloride, p-chlorosulfonyl chloride, p-methoxysulfonyl chloride, 2-methylsulfonyl chloride, 1-naphthylsulfonyl chloride, 2,4,6-trimethylsulfonyl chloride, It may be 2,4,6-triphenylsulfonyl chloride.
- Preferred is p-toluenesulfonyl chloride. 1 to 5 equivalents of the activating agent can be used with respect to compound (2c). It is preferably 1.5 to 2.5 equivalents.
- the solvent is not particularly limited as long as it dissolves the starting material and does not inhibit the reaction.
- examples include trifluoromethylbenzene, toluene, ethyl acetate, isopropyl acetate, tetrahydrofuran, 2-methyltetra Hydrofuran, tert-butyl methyl ether, dimethoxyethane, cyclopentyl methyl ether, 4-methyltetrahydropyran, water or a mixed solvent thereof may be used.
- Preferred is a mixed solvent of toluene, 4-methyltetrahydropyran and water.
- the reaction temperature usually varies depending on the starting material, solvent, and other reagents used in the reaction, and is -50°C to room temperature, preferably -20°C to 10°C.
- Step 2-d) is a step of removing PG 1 in compound (2e) to obtain compound (2f).
- deprotection can be performed under deprotection conditions according to the protecting group.
- a tert-butoxide carbonyl group and a benzyloxycarbonyl group can be deprotected under basic conditions.
- bases include sodium hydroxide, potassium hydroxide, sodium tert-butoxide, potassium tert-butoxide, potassium carbonate, tert-butylamine, sodium methoxide, sodium ethoxide.
- Sodium hydroxide is preferred.
- the base is 1 to 10 equivalents, more preferably 2 to 4 equivalents, relative to compound (2e).
- the solvent is not particularly limited as long as it dissolves the starting material and does not inhibit the reaction.
- ethanol, tetrahydrofuran, dimethylsulfoxide, methanol, water, or a mixed solvent thereof may be used.
- a mixed solvent of ethanol, tetrahydrofuran and water is preferred.
- the reaction temperature usually varies depending on the starting material, solvent, and other reagents used in the reaction, and may range from 30°C to 70°C. Preferably it is 40°C to 60°C.
- Step 2-e) is a step of reacting compound (2f) with compound (2g-1) or compound (2g-2) in the presence of a base to obtain compound (2h).
- Compound (2g-1) or compound (2g-2) may be, for example, phenylmethylcarbamate, ethylmethylcarbamate, methylaminocarbonyl chloride, or methylaminocarbonyl bromide.
- Phenylmethyl carbamate is preferred.
- phenylmethyl carbamate can be used in an amount of 1.0 to 2.0 equivalents relative to compound (2f). It is preferably 1.2 to 1.4 equivalents.
- the base may be sodium hydroxide, potassium hydroxide, sodium tert-butoxide, potassium tert-butoxide. Potassium tert-butoxide is preferred. 0.1 to 3.0 equivalents of the base can be used with respect to compound (2f). Preferably, it is 1.0 to 1.5 equivalents.
- the solvent is not particularly limited as long as it dissolves the starting material and does not inhibit the reaction.
- it may be tetrahydrofuran, dimethylformamide, dimethylsulfoxide, or a mixed solvent thereof.
- Preferred is a mixed solvent of tetrahydrofuran and dimethylsulfoxide.
- the reaction temperature usually varies depending on the starting material, solvent, and other reagents used in the reaction, and may range from -10°C to room temperature. Preferably it is 0°C.
- Step 2-f) is a step of removing R 1 in compound (2h) to obtain compound (2i), and optionally obtaining a salt of compound (2i).
- step 2-f) depending on R 1 , the conditions for removing R 1 can be selected.
- R 1 is a cumyl group or an octyl group
- hydrochloric acid, sulfuric acid, formic acid, and methanesulfonic acid can be used as acids. Methanesulfonic acid is preferred.
- Salts include, for example, inorganic acid salts (sulphates, nitrates, perchlorates, phosphates, carbonates, bicarbonates, hydrofluorates, hydrochlorides, hydrobromides and hydroiodic salts, etc.), organic carboxylates (such as acetates, oxalates, maleates, tartrates, fumarates and citrates), organic sulfonates (methanesulfonates, trifluoromethanesulfonates, ethane sulfonates, benzenesulfonates, toluenesulfonates and camphorsulfonates, etc.), amino acid salts (aspartates and glutamates, etc.).
- inorganic acid salts sulphates, nitrates, perchlorates, phosphates, carbonates, bicarbonates, hydrofluorates, hydrochlorides, hydrobromides and hydroiodic salts, etc.
- Methanesulfonate is preferred. By converting compound (2i) into a salt, it becomes possible to store it stably for a long period of time.
- a method for synthesizing the methanesulfonate of compound (2i) from compound (2h) via removal of R1 is shown below.
- the amount of methanesulfonic acid may be 1 to 20 equivalents relative to compound (2h). It is preferably 5 to 10 equivalents.
- the reaction solvent is not particularly limited as long as it dissolves the starting material and does not inhibit the reaction.
- it may be ethanol, methanol, dimethoxyethane, or a mixed solvent thereof.
- Preferred is a mixed solvent of ethanol and methanol.
- the reaction temperature usually varies depending on the starting material, solvent, and other reagents used in the reaction, and may range from room temperature to 80°C. Preferably it is 20°C to 50°C.
- room temperature usually indicates about 10°C to about 35°C. % indicates percent by weight unless otherwise specified.
- the obtained crystals were washed with a mixed solution of tert-butyl methyl ether (30 L)/ethyl acetate (3 L)/methanol (3 L), and the obtained crystals were dried under reduced pressure at an internal temperature of 50° C. or less to obtain 10.7 kg of the title compound. Obtained.
- a mixture of water (129 L)/hydrochloric acid (12.8 kg) was added dropwise to the organic layer to separate the organic layer.
- the organic layer was washed with 5% aqueous sodium bicarbonate solution (141 kg) and 3% saline solution (146 kg), and then concentrated under reduced pressure to 85 L.
- Ethyl acetate (144 L) and 10% aqueous sodium chloride solution (57 kg) were added to the concentrated residue, and the organic layer was washed.
- the organic layer was concentrated under reduced pressure to 85L.
- Heptane (28 L) and sodium sulfate (14.1 kg) were added to the resulting concentrated residue and stirred.
- the mixture was purified by passing through NH silica gel (28.2 kg) wet with ethyl acetate (141 L). After that, the NH silica gel was washed with a mixture of ethyl acetate (226 L)/heptane (57 L) and mixed with the purified liquid. The mixture was concentrated under reduced pressure to 85 L at 50°C, heptane (64 L) was added dropwise to the concentrated residue, and concentrated under reduced pressure to 85 L at 50°C. After adding ethyl acetate (27 L) and heptane (60 L) and cooling to 0 to 10° C., the precipitated solid was filtered.
- n-Heptane (145 kg) was added dropwise over 1.5 hours, and the mixture was stirred at an internal temperature of -10 to 0°C for 3 hours.
- the suspension was filtered and washed with a mixture of ethyl acetate (5.7 kg) and n-heptane (8.7 kg).
- the obtained crystals were dried under reduced pressure at 40° C. to obtain 20.2 kg of the title compound.
- reaction solution was concentrated under reduced pressure at 40° C. or lower to 90 L.
- Methanol (78.3 kg) and potassium carbonate (10.6 kg, 76.4 mol, 0.8 eq.) were added to the obtained concentrate under a nitrogen atmosphere, and the mixture was stirred at 34° C. for 14 hours.
- ethyl acetate (178.6 kg) and water (138.6 kg) were added, and 5N hydrochloric acid (35% hydrochloric acid 15.2 kg, water 16.3 kg) was added dropwise.
- the organic layer was washed with 5% saline (salt 3.0 kg, water 56.4 kg). The organic layer was concentrated under reduced pressure at 50° C.
- Production Example 8 4- ⁇ [6-(2-methoxyethoxy)-1H-indol-5-yl]oxy ⁇ -N-(2,4,4-trimethylpentan-2-yl)pyridin-2-amine ( 2f-1) manufacturing
- Methyl tert-butyl ether (49.7 kg) was added to the concentrate, and the mixture was stirred at 48° C. for 73 minutes. After cooling the suspension to 0° C., it was filtered and washed with n-propanol (53.6 kg). The obtained crystals were dried under reduced pressure at 50° C. or less to obtain 22.93 kg of the title compound.
- Production Example 10-2 5-((2-aminopyridin-4-yl)oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide methanesulfonate ((2i) methanesulfonate) production
- Methanesulfonic acid (117.7 kg, 1225 mol, 12.0 eq.) was added, washed with methanol (4.7 kg), stirred at 25-32°C for 21 hours, and 5-((2-aminopyridin-4-yl ) Oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide (46 g) was added.
- Methyl tert-butyl ether (355.3 kg) was added dropwise to the crystal-precipitated suspension, and the mixture was cooled to 2-5°C.
- the precipitated solid was filtered and washed with a mixture of methyl tert-butyl ether (126.8 kg) and ethanol (54.0 kg) and isopropyl acetate (208.7 kg).
- the obtained crystals were dried under reduced pressure at 50° C. or less to obtain 38.04 kg of the title compound.
- Production Example 11-2 Production of 5-((2-aminopyridin-4-yl)oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide (2i)
Abstract
Description
[1]化合物(2i)
2-a)化合物(1g)
化合物(2a)
を製造する工程2-a)と、
2-b)工程2-a)で得られる化合物(2a)と化合物(2b)
2-c)工程2-b)で得られる化合物(2c)と化合物(2d)
2-d)工程2-c)で得られる化合物(2e)におけるPG1を除去して、化合物(2f)
2-e)工程2-d)で得られる化合物(2f)と化合物(2g-1)または化合物(2g-2)
とを塩基存在下反応させて、化合物(2h)
2-f)工程2-e)で得られる化合物(2h)におけるR1を除去して、化合物(2i)
[2]化合物(2b)が、4-ニトロピリジン-1-イウム-オレートである、[1]記載の製造方法、
[3]化合物(2d)が、1,1,3,3-テトラメチルブチルアミンである、[1]記載の製造方法、
[4]化合物(2d)が、クミルアミンである、[1]記載の製造方法、
[5]活性化剤が、p-トルエンスルホニルクロライドである、[1]記載の製造方法、
[6]化合物(1g)
1-a)1,2-(メチレンジオキシ)-4-ニトロベンゼンと4-ブロモベンジルアルコールとを塩基存在下反応させて、化合物(1c)
1-b)工程1-a)で得られる化合物(1c)とメトキシエチル化剤とを塩基存在下反応させて、化合物(1d)
1-c)工程1-b)で得られる化合物(1d)とシアノメチル化剤とを塩基存在下反応させて、化合物(1f)
1-d)工程1-c)で得られた化合物(1f)におけるニトロ基のアミノ基への変換、4-ブロモベンジル基の除去、および酸触媒による閉環により、化合物(1g)
[7]工程1-d)において、パラジウム触媒及び硫酸を使用する、[6]記載の製造方法。
1H NMR Spectrum(DMSO-d6)δ(ppm): 5.23(2H, s), 7.17(1H, d, J=9.1Hz), 7.44(2H, br d, J=8.3Hz), 7.60(2H, br d, J=8.3Hz), 7.63(1H, d, J=2.6Hz), 7.71(1H, dd, J=9.1, 2.6Hz)
1H NMR Spectrum (DMSO-d6)δ(ppm): 3.28(3H, s), 3.68(2H, t, J=4.5Hz), 4.23(2H, t, J=4.2Hz), 5.26(2H, s), 7.23(1H, d, J=9.1Hz), 7.41(2H, br d, J=7.9Hz), 7.60(2H, br d, J=7.9Hz), 7.79(1H, d, J=2.3Hz), 7.88(1H, dd, J=8.7, 1.9Hz)
1H-NMR Spectrum(CDCl3)δ(ppm):3.46(3H, s), 3.81(2H, t, J=4.8Hz), 4.19(2H, s), 4.25(2H, t, J=4.4Hz), 5.23(2H, s), 7.14(1H, s), 7.35(2H, d, J=8.0Hz), 7.54(2H, d, J=8.4Hz), 7.84(1H, s)
1H NMR Spectrum(DMSO-d6)δ(ppm): 3.32(3H, s), 3.66-3.69(2H, m), 4.04-4.07(2H, m), 6.16(1H, t, J=2.1Hz), 6.88(2H, d, J=4.2Hz), 7.07(1H, dd, J=2.8, 2.5Hz), 8.08(1H, s), 10.57(1H, br s)
1H NMR Spectrum(DMSO-d6)δ(ppm): 1.61(9H, s), 3.32(3H, s), 3.68-3.71(2H, m), 4.08-4.11(2H, m), 6.49(1H, d, J=3.6Hz), 6.95(1 H, s), 7.44(1H, d, J=3.6Hz), 7.59(1H, s), 8.75(1H, s)
1H NMR Spectrum(DMSO-d6)δ(ppm): 1.63(9H, s), 3.16(3H, s), 3.49-3.52(2H, m), 4.09- 4.12(2H, m), 6.65(1H, d, J=3.8Hz), 6.83 -6.87(2H, m), 7.48(1H, s), 7.62(1H, d, J=3.6Hz), 7.82(1H, br s), 8.04-8.07(2H, m)
1H NMR Spectrum(CD3OD)δ(ppm): 0.89(9H, s), 1.30(6H, s), 1.64(2H, s), 3.27(3H, s), 3.56-3.59(2H, m), 4.05-4.09(2H, m), 5.85(1 H, d, J=2.3Hz), 6.15(1H, dd, J=6.0, 2.3Hz), 6.36-6.39(1H, m), 7.11(1H, s), 7.17(1 H, d, J=3.4Hz), 7.25(1H, s), 7.74(1H, d, J=6.0Hz)
1H NMR Spectrum(CD3OD)δ(ppm): 0.93(9H, s), 1.35(6H, s), 1.71(2H, s), 2.98(3H, s), 3.30(3H, s),3.62-3.64(2H, m), 4.13-4.16(2H, m), 5.88(1H, d, J=2.3Hz), 6.18(1H, dd, J=5.9, 2.3Hz), 6.61(1H, d, J=3.2Hz), 7.32(1H, s), 7.58(1H, d, J=3.8Hz), 7.79(1H, d, J=5.9Hz), 8.08(1H, s)
1H NMR Spectrum (DMSO-d6)δ(ppm): 2.32(3H, s), 2.84(3H, d, J=4.5Hz), 3.15(3H, s), 3.51-3.54(2H, m), 4.08-4.11(2H, m), 6.01(1H, d, J=2.3Hz), 6.63-6.66(2H, m), 7.50(1H, s), 7.61(2H, br s), 7.79(1H, d, J=3.8Hz), 7.90(1H, d, J=7.2Hz), 8.10(1H, s), 8.18(1H, q, J=4.2Hz), 12.82(1H, brs)
1H NMR Spectrum (DMSO-d6)δ(ppm): 2.83(3H, d, J=4.4Hz), 3.18(3H, s), 3.50-3.54(2H, m), 4.04-4.08(2H, m), 5.69(1H, d, J=1.8Hz), 5.76(2H, s), 6.09(1H, dd, J=5.7, 2.2Hz), 6.59(1H, d, J=3.5Hz), 7.33(1H, s), 7.71-7.74(2H, m), 8.03(1H, s), 8.10-8.14(1H, m)
Claims (7)
- 化合物(2i)
2-a)化合物(1g)
化合物(2a)
を製造する工程2-a)と、
2-b)工程2-a)で得られる化合物(2a)と化合物(2b)
2-c)工程2-b)で得られる化合物(2c)と化合物(2d)
2-d)工程2-c)で得られる化合物(2e)におけるPG1を除去して、化合物(2f)
2-e)工程2-d)で得られる化合物(2f)と化合物(2g-1)または化合物(2g-2)
とを塩基存在下反応させて、化合物(2h)
2-f)工程2-e)で得られる化合物(2h)におけるR1を除去して、化合物(2i)
- 化合物(2b)が、4-ニトロピリジン-1-イウム-オレートである、請求項1記載の製造方法。
- 化合物(2d)が、1,1,3,3-テトラメチルブチルアミンである、請求項1記載の製造方法。
- 化合物(2d)が、クミルアミンである、請求項1記載の製造方法。
- 活性化剤が、p-トルエンスルホニルクロライドである、請求項1記載の製造方法。
- 化合物(1g)
1-a)1,2-(メチレンジオキシ)-4-ニトロベンゼンと4-ブロモベンジルアルコールとを塩基存在下反応させて、化合物(1c)
1-b)工程1-a)で得られる化合物(1c)とメトキシエチル化剤とを塩基存在下反応させて、化合物(1d)
1-c)工程1-b)で得られる化合物(1d)とシアノメチル化剤とを塩基存在下反応させて、化合物(1f)
1-d)工程1-c)で得られた化合物(1f)におけるニトロ基のアミノ基への変換、4-ブロモベンジル基の除去、および酸触媒による閉環により化合物(1g)
- 工程1-d)において、パラジウム触媒及び硫酸を使用する、請求項6記載の製造方法。
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004002410A2 (en) * | 2002-06-27 | 2004-01-08 | Bristol-Myers Squibb Company | 2,4-disubstituted-pyridine n-oxides useful as hiv reverse transcriptase inhibitors |
WO2009117421A2 (en) * | 2008-03-17 | 2009-09-24 | Kalypsys, Inc. | Heterocyclic modulators of gpr119 for treatment of disease |
WO2014129477A1 (ja) | 2013-02-20 | 2014-08-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 単環ピリジン誘導体 |
WO2016027781A1 (ja) | 2014-08-18 | 2016-02-25 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 単環ピリジン誘導体の塩およびその結晶 |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004002410A2 (en) * | 2002-06-27 | 2004-01-08 | Bristol-Myers Squibb Company | 2,4-disubstituted-pyridine n-oxides useful as hiv reverse transcriptase inhibitors |
WO2009117421A2 (en) * | 2008-03-17 | 2009-09-24 | Kalypsys, Inc. | Heterocyclic modulators of gpr119 for treatment of disease |
WO2014129477A1 (ja) | 2013-02-20 | 2014-08-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 単環ピリジン誘導体 |
WO2016027781A1 (ja) | 2014-08-18 | 2016-02-25 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 単環ピリジン誘導体の塩およびその結晶 |
Non-Patent Citations (2)
Title |
---|
IMAKURA Y, ET AL.: "REGIOSELECTIVE CLEAVAGE REACTION OF THE AROMATIC METHYLENEDIOXY RING. V. CLEAVAGE WITH SODIUM ALKOXIDES-ALCOHOLS, POTASSIUM TERT-BUTOXIDE-ALCOHOLS, DIMSYL ANION-METHYL ALCOHOL, METALLIC SODIUM-ALCOHOLS, AND SODIUM CYANIDE IN DIPOLAR APROTIC SOLVENTS", CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 40, no. 07, 1 July 1992 (1992-07-01), JP , pages 1691 - 1696, XP001148863, ISSN: 0009-2363 * |
YIN JINGJUN ET AL: "A general and efficient 2-amination of pyridines and quinolines", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 72, no. 12, 1 June 2007 (2007-06-01), pages 4554 - 4557, XP002514944, ISSN: 0022-3263, DOI: 10.1021/JO070189Y * |
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