WO2022222898A1 - 一种包括流量反馈装置的微透析系统 - Google Patents

一种包括流量反馈装置的微透析系统 Download PDF

Info

Publication number
WO2022222898A1
WO2022222898A1 PCT/CN2022/087508 CN2022087508W WO2022222898A1 WO 2022222898 A1 WO2022222898 A1 WO 2022222898A1 CN 2022087508 W CN2022087508 W CN 2022087508W WO 2022222898 A1 WO2022222898 A1 WO 2022222898A1
Authority
WO
WIPO (PCT)
Prior art keywords
weighing
liquid
flow feedback
collection tank
flow
Prior art date
Application number
PCT/CN2022/087508
Other languages
English (en)
French (fr)
Inventor
郝祥仪
张云虹
Original Assignee
上海花涯自动化科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 上海花涯自动化科技有限公司 filed Critical 上海花涯自动化科技有限公司
Publication of WO2022222898A1 publication Critical patent/WO2022222898A1/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601—Control or regulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A61M1/1643—Constructional aspects thereof with weighing of fresh and used dialysis fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A61M1/1647—Constructional aspects thereof with flow rate measurement of the dialysis fluid, upstream and downstream of the dialyser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A61M1/1656—Apparatus for preparing dialysates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24—Dialysis ; Membrane extraction
    • B01D61/32—Controlling or regulating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3334—Measuring or controlling the flow rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3379—Masses, volumes, levels of fluids in reservoirs, flow rates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
    • A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback

Definitions

  • the invention relates to the field of medical equipment, in particular to a microdialysis system comprising a flow feedback device.
  • microdialysis experiments/treatments require long-term dialysis (more than a few hours) each time, and some require online analysis and monitoring of the collected dialysate, the following situations often occur in microdialysis experiments/treatments: (1) The microdialysis probe or the connecting pipeline is blocked; (2) The connecting pipeline is leaking and leaking; (3) The syringe is not installed properly, etc., so whether the entire connecting pipe and supporting equipment are operating normally requires a timely Monitoring, judgment, and alarm devices to assist experiment/treatment.
  • the microdialysis system can monitor the flow state of the connecting pipeline of the microdialysis system by weighing the collected liquid, and the system integrates the liquid collection and automatic drain function.
  • the purpose of the present invention is to provide a microdialysis system including a flow feedback device, the microdialysis system can monitor the flow state of the connecting pipeline of the microdialysis system by weighing the collected liquid, and the system integrates the liquid collection and automatic drain function.
  • the present invention provides a microdialysis system including a flow feedback device, including:
  • the flow feedback device includes a connection needle, a liquid collection tank, a calibration weighing module, and a flow feedback control display module;
  • the input device includes a micro-flow pump and a syringe, and the micro-flow pump pumps the dialysable medium into the first connecting pipeline through the syringe;
  • One end of the first connecting line is fluidly connected to the syringe, the other end of the first connecting line is fluidly connected to the inlet of the microdialysis probe, and the first connecting line is used to deliver the dialysable substance to a microdialysis probe, whereby the dialysable substance enters the living organism through the microdialysis probe;
  • the second connecting line is used to deliver the dialysis liquid from the living organism to the flow feedback device, one end of the second connecting line is fluidly connected with the outlet of the microdialysis probe, and the second connecting line is The other end is fluidly connected with the connecting needle;
  • the liquid collection tank is arranged below the connecting needle and is used for collecting dialysis liquid from living organisms;
  • the calibration weighing module is used to measure the weight of the liquid in the liquid collection tank regularly according to the conditions and programs set in the flow feedback control display module and transmit the measured liquid weighing value to the flow feedback control display module;
  • the flow feedback control display module makes the difference between the current liquid weighing value and the last liquid weighing value to obtain the weighing sampling difference value, and compares the weighing sampling difference value with a predetermined value, so as to monitor whether the connection needle is The liquid is discharged normally, and then the state of the fluid flow in the first connecting pipeline and the second connecting pipeline is fed back.
  • the dialysis liquid from the living organism is selected from the group consisting of: the dialysis liquid of the living organism subjected to microdialysis, the liquid formed after the dialysis liquid undergoes a biochemical reaction, or a combination thereof.
  • the flow feedback display module further includes a display screen, the display screen is used to display the current liquid weight value and the difference value of the weighing sample for the user to monitor the change of the liquid weight.
  • the flow feedback control and display module of the flow feedback device may further include an alarm module, which sends an alarm signal to the user when the weighing sample difference is not equal to a predetermined value.
  • the calibration weighing module performs automatic calibration before weighing the dialysis fluid collected in the fluid collection tank.
  • the calibration weighing module includes a stage, a pressure sensor, a lifting mechanism and a rotating motor, the pressure sensor and the rotating motor are arranged under the stage, and the lifting mechanism Mechanisms are provided on the sides of the stage.
  • the calibration weighing module includes a stage, the stage includes a first subsection and a second subsection, the liquid collection tank is arranged on the first subsection, and the liquid collection tank is arranged on the first subsection. Custom weights are set on the second partition.
  • the stage is an L-shaped stage.
  • the calibration weighing module further includes a pressure sensor, and the pressure sensor is arranged below the stage.
  • the pressure sensor when the calibration weighing module is weighing, the pressure sensor is arranged directly below the first partition of the stage; when the calibration weighing module is being calibrated, the pressure sensor is The pressure sensor is disposed directly below the second sub-section of the stage.
  • a weighing pan is connected to the pressure sensor, and when the calibration weighing module is automatically calibrated, the liquid collection tank is separated from the weighing pan.
  • the calibration weighing module further includes a lift mechanism, the lift mechanism includes a lift motor and a lead screw, and the lift mechanism drives the stage to move away from or approach to the vertical direction The pressure sensor moves.
  • the lead screw is connected to the stage, and the lift motor is connected to the lead screw.
  • the calibration weighing module further includes a rotating motor, the rotating motor is connected to the object platform, and the rotating motor is used to drive the object platform to rotate in a horizontal plane.
  • the calibration weighing module further includes a rotating motor, and the rotating motor cooperates with the lifting mechanism to switch the liquid collection tank and the customized weight on the pressure sensor, so as to realize the adjustment of the liquid collection tank in the liquid collection tank. liquids are weighed and calibrated with custom weights.
  • a weighing pan is connected to the pressure sensor, and the weighing pan includes a weighing pan head;
  • the first section of the stage is provided with a first through hole
  • the bottom of the liquid collection tank is provided with an annular protrusion of the collection tank
  • the annular protrusion of the collection tank passes through the first through hole and is There is a certain gap between the annular protruding part of the collection tank and the first through hole, and when the weighing module is calibrated for weighing, the head of the weighing pan is embedded in the annular protruding part of the collection tank.
  • the liquid collection tank includes a tank mouth and a tank body, the collection tank annular protrusion is provided at the bottom of the tank body, and the diameter of the tank mouth is much smaller than the diameter of the tank body.
  • the second partition is provided with a second through hole
  • the bottom of the customized weight is provided with a weight annular protrusion
  • the weight annular protrusion passes through the second through hole.
  • the lifting mechanism lifts the stage in a vertical direction so that the liquid collection tank is separated from the head of the weighing pan, Then the rotating motor rotates the stage, so that the second section of the stage is located above the pressure sensor, the flow feedback control display module makes the pressure sensor automatically zero, and then the lifting mechanism The weight ring protrusion of the stage is vertically lowered to the custom weight embedded in the weighing pan head (that is, the weighing pan holds the custom weight, and the pressure sensor will measure The signal is transmitted to the flow feedback control display module, so that the flow feedback control display module completes the calibration according to internal instructions.
  • the calibration weighing module when the calibration is completed, performs weighing, and the lifting mechanism lifts the stage in the vertical direction so that the customized weight is separated from the weighing pan head Then the rotating motor rotates the stage, so that the first section of the stage is located above the pressure sensor, the flow feedback control display module makes the pressure sensor automatically zero, and then the lifting The lifting mechanism lowers the stage in the vertical direction until the annular protrusion of the collection tank is embedded in the head of the weighing pan (that is, the weighing pan supports the liquid collection tank), and the pressure sensor will measure the The signal is transmitted to the flow feedback control display module, and the measured signal is processed and displayed on the display screen of the flow feedback control display module.
  • the flow feedback control display module includes a signal processor and a controller.
  • the signal processor is used to convert the voltage signal generated by the pressure sensor into an analog quantity to a digital quantity, and the signal processor simultaneously receives the instructions sent by the controller, and performs zero reset, calibration, reading Pressure sensor signals and other commands, the controller is used to control the lifting mechanism in the calibration weighing module and the action of rotating the motor.
  • the flow feedback control and display module includes a host computer for calculating, displaying, modifying parameters, and alarming the sampled values.
  • the calibration weighing module further includes a pressure sensor, and the pressure sensor is weighed through the connected weighing pan.
  • the flow feedback controls the display module.
  • the pressure sensor will be automatically reset to zero.
  • the annular protrusion of the collection tank of the weighing pan embedded in the liquid collection tank supports the liquid collection tank, and the through hole of the stage will form with the bottom of the weighing pan and the liquid collection tank.
  • the flow feedback control display module makes the signal of the pressure sensor process and display the corresponding data on the display screen.
  • the bottom of the customized weight also has a weight annular protrusion.
  • the flow feedback control display module will automatically reset the pressure sensor to zero.
  • the stage is lowered, the weighing pan is embedded in the annular protrusion of the custom weight to hold the custom weight, the through hole of the stage will form a gap completely separated from the bottom of the weighing pan and the custom weight, and the flow feedback controls the signal of the display module
  • the processor receives the signal data of the pressure sensor, and then completes the calibration according to the instructions of the controller.
  • the flow feedback device further includes a housing, the connecting needle is arranged on the housing, and the liquid collection tank and the calibration weighing module are arranged in the housing.
  • the flow feedback device further includes an automatic liquid discharge mechanism, and the flow feedback device of the automatic liquid discharge mechanism is used to discharge the liquid in the liquid collection tank.
  • the flow feedback device further includes a base, and the liquid collection tank, the calibration weighing module, and the automatic liquid discharge mechanism are arranged above the base.
  • the flow feedback device is portable.
  • the signal processor and the controller are arranged in the base.
  • the automatic liquid discharge mechanism includes a liquid discharge pump and a liquid discharge pipe, and when the weighing value of the liquid in the liquid collection tank reaches a maximum set threshold, the flow feedback control display module will make the lifting The lifting mechanism cooperates with the rotating motor, so that the liquid drain pipe is inserted into the liquid collection tank, and the liquid drain pump is activated to discharge the liquid in the liquid collection tank.
  • the automatic liquid discharge mechanism operates independently of the calibration weighing module.
  • the weighing accuracy of the weighing calibration module is within the range of ⁇ 0.003g.
  • the speed of the micro-flow pump passing through the designated syringe and connecting pipeline is 0.05uL/min-30uL/min.
  • the calibration weighing module can set the interval of timed weighing according to the flow rate.
  • the calibration weighing module is used for calibrating the calibration weighing module before entering the weighing program according to the conditions and programs set in the flow feedback control display module.
  • the flow feedback control display module can perform parameter setting and action control on the calibration weighing module and the automatic liquid discharge mechanism.
  • the connecting needle, the first and second connecting lines and the syringe are all disposable in a medical environment.
  • the microdialysis system further includes other connecting pipelines.
  • FIG. 1 is a schematic diagram of a microdialysis system including a flow feedback device according to the present invention
  • Figure 2 is a schematic diagram of a portion of the components of a flow feedback device according to the present invention.
  • FIG. 3 is a schematic three-dimensional structure diagram of a flow feedback device according to an embodiment of the present invention.
  • FIG. 4 is a schematic three-dimensional structural diagram of a housing of a flow feedback device according to an embodiment of the present invention.
  • FIG. 5 is a cross-sectional view of a flow feedback device according to an embodiment of the present invention.
  • FIG. 6 is a schematic structural diagram of the A-A section of FIG. 5 .
  • a microdialysis system including a flow feedback device for the first time. Heavy data analysis and calculation, and then monitor the flow status of the first connecting pipeline and the second connecting pipeline of the microdialysis system, can find the problem of flow rate change in a short time, and then analyze and judge the following faults: (1 ) Whether the microdialysis probe or connecting pipeline is blocked; (2) Whether the connecting pipeline is leaking or leaking gas; (3) Whether the syringe is not installed properly, etc.
  • the flow feedback device also includes a display screen, and the user can view the flow trend diagram of the micro-flow pipeline through the monitoring screen to determine the relative stable state of the pipeline, and the flow feedback device also integrates an automatic drainage mechanism. The liquid in the liquid collection tank is pumped to the external liquid bag/tank when the liquid in the liquid reaches the maximum set threshold.
  • weighed value and “weighed sample value” are used interchangeably;
  • an action is performed according to a certain element, it means at least that the action is performed according to the element, which includes two situations: the action is performed only according to the element, and the action is performed according to the element and Other elements perform this behavior.
  • Expressions such as multiple, multiple, multiple, etc. include 2, 2, 2, and 2 or more, 2 or more, and 2 or more.
  • a flow feedback device 4 with a unique structure is provided, which includes a housing 40 , a connecting needle 41 , a liquid collection tank 42 , a calibration weighing module 43 , a flow feedback control display module 44 and an automatic liquid discharge mechanism 45 .
  • the flow feedback control display module 44 may include an alarm module.
  • the liquid collection tank 42 is arranged below the connecting needle 41 and is used to collect the dialysis liquid from the living organism; the calibration weighing module 43 is used to measure the liquid in the liquid collection tank 42 according to the conditions set in the flow feedback control display module 44 and the program timing and transmit the measured liquid weighing value to the flow feedback control display module 44;
  • the flow feedback control display module 44 makes the difference between the current liquid weighing value and the last liquid weighing value to obtain the weighing sampling difference value, and compares the weighing sampling difference value with the predetermined value, so as to monitor whether the connecting needle 41 is normally out. fluid, and then feedback the state of fluid flow in the first connecting pipeline 2 and the second connecting pipeline 3.
  • the alarm module sends an alarm signal to the user.
  • the calibration weighing module 43 includes a stage 430 , a custom weight 431 , a pressure sensor 432 , a lifting mechanism 433 and a rotating motor 434 , the pressure sensor 432 and the rotating motor 434 Provided below the stage 430 , the lift mechanism 433 is provided on the side of the stage 430 .
  • the connecting needle 41 is arranged on the outer cover 40 to be connected to the outlet of the second connecting pipe, and the liquid collection tank 42, the calibration weighing module 43, and the automatic liquid draining mechanism 45 are all arranged in the outer cover 40 to further prevent the outside air from being leaked. into the liquid collection tank 42, affecting the accuracy of the calibrated weigh module.
  • the connecting needle 41 , the first connecting line 2 , the second connecting line 3 and the syringe are all disposable.
  • the size of the needle is usually selected according to the set liquid flow rate. The principle is to ensure that the gap time for the formation of droplets can ensure that the weighing calibration module completes one weighing action. For example, when the flow rate is 0.05-0.5ul/min, you can choose G30 needle, and when the flow rate is 5ul/min, you can choose G23 needle. When the flow rate is higher, we can even make the tip of the droplet into a larger plane. Make sure that the gap time between drops is long enough to form larger droplets.
  • the flow feedback control display module 44 includes a signal processor and a controller, and preferably, the flow feedback device 4 further includes a base 46, and the liquid collection tank 42, the calibration weighing module 43, and the automatic liquid discharge mechanism 45 are arranged on the Above the base 46 , in order to make the flow feedback device compactly arranged, the signal processor and the controller are arranged in the base 46 .
  • the liquid is collected by the connecting needle at the end of the connecting pipe to collect the drop of liquid into the liquid collection tank by gravity in a non-contact state.
  • the fluid flow automatic feedback system detects the liquid in the liquid bottle
  • the automatic liquid discharge mechanism starts to work, and the liquid is pumped and discharged from the liquid collection tank to the liquid bag/tank. Fluid bags/tanks are regularly replaced by staff.
  • the status of the fluid flow in the connecting pipe is fed back according to whether the collected dialysate/liquid has a normal mass increase within a specified time, or whether its stagnation time is normal when no liquid is discharged (1 normal/2 blocked liquid/ 3. There is leakage), after the alarm prompts, personnel shall intervene to check whether there is any abnormal phenomenon in the connecting pipe and supporting equipment.
  • Microdialysis system including flow feedback device
  • a microdialysis system including a flow feedback device
  • the system includes: an input device 1, a first connecting line 2, a second connecting line 3 and a flow feedback device 4; wherein, the input device 1 Including a micro-flow pump and a syringe, the micro-flow pump pumps the dialysable medium into the first connecting line 2 through the syringe; one end of the first connecting line 2 is fluidly connected with the syringe, and the other end of the first connecting line 2 is connected with the syringe.
  • the inlet of the microdialysis probe is fluidly connected, and the first connection pipeline 2 is used to transport the dialysable substance to the microdialysis probe, so that the dialysable substance enters the living organism through the microdialysis probe; the second connection pipeline 3 is used to connect the The dialysis liquid of the living organism is delivered to the flow feedback device 4 , one end of the second connection pipeline 3 is fluidly connected to the outlet of the microdialysis probe, and the other end of the second connection pipeline 3 is fluidly connected to the flow feedback device 4 .
  • the dialysis fluid from the living organism is selected from the group consisting of dialysis fluid from the living organism that has undergone microdialysis, a fluid formed by biochemical reactions of the dialysis fluid, or a combination thereof.
  • the speed of the microflow pump through the designated syringe and connecting tubing is 0.05uL/min-30uL/min.
  • the microdialysis system further includes other connecting lines.
  • the second connecting line in a system with fluid (dialysis fluid) generation, can incorporate more connecting pipes before entering the flow feedback device, and the second connecting line includes these incorporated connecting pipes.
  • the present invention provides a microdialysis system including a flow feedback device, the system includes: an input device 1, a first connecting line 2, a second connecting line 3 and a flow feedback device 4;
  • the flow feedback device 4 includes an outer cover 40, a connecting needle 41, a liquid collection tank 42, a calibration weighing module 43, a flow feedback control display module 44 and an automatic liquid discharge mechanism 45; the specification of the connecting needle 42 is selected according to the agreed liquid flow rate range.
  • the input device 1 includes a micro-flow pump and a syringe, and the micro-flow pump pumps the dialysable medium into the first connecting line 2 through the syringe; one end of the first connecting line 2 is fluidly connected with the syringe, and the first connecting line 2 The other end of 2 is fluidly connected to the inlet of the microdialysis probe, and the first connection pipeline 2 is used to transport the dialysable substance to the microdialysis probe, so that the dialysable substance enters the living organism through the microdialysis probe; the second connection pipeline 3 is used to deliver the dialysis liquid from the living organism to the flow feedback device 4, one end of the second connecting line 3 is fluidly connected with the outlet of the microdialysis probe, and the other end of the second connecting line 3 is fluidly connected with the connecting needle 41 ;
  • the liquid collection tank 42 is arranged below the connecting needle 41 and is used to collect the dialysis liquid from the living organism; the calibration weighing module 43 is used to measure the liquid in the liquid collection tank 42 according to the conditions set in the flow feedback control display module 44 and the program timing and transmit the measured liquid weighing value to the flow feedback control display module 44;
  • the flow feedback control display module 44 makes the difference between the current liquid weighing value and the last liquid weighing value to obtain the weighing sampling difference value, and compares the weighing sampling difference value with the predetermined value, so as to monitor whether the connecting needle 41 is normally out. fluid, and then feedback the state of fluid flow in the first connecting pipeline 2 and the second connecting pipeline 3.
  • the calibration weighing module 43 includes a stage 430, a pressure sensor 432, a lifting mechanism 433 and a rotating motor 434;
  • the flow feedback control and display module 44 includes a signal processor and a controller.
  • the liquid collection tank 42 includes a tank mouth and a tank body.
  • the diameter of the tank mouth is configured to be much smaller than the diameter of the tank body.
  • the annular protrusion of the collection tank is configured to be much smaller than the diameter of the tank body.
  • the pressure sensor 432 is arranged below the object platform 430, and a weighing pan is connected to the pressure sensor 432, and the weighing pan includes a weighing pan head.
  • the function of the annular protrusion of the collection tank is not only to be fixed on the stage, but also to align the weighing pan with the annular protrusion of the collection tank to stably carry the liquid collection tank.
  • the stage 430 includes a first section and a second section, the liquid collection tank 42 is disposed on the first section, and the custom weight is disposed on the second section.
  • the stage 430 is L-shaped.
  • the pressure sensor 432 when the calibration weighing module 43 is weighing, the pressure sensor 432 is disposed directly below the first partition of the stage 430; when the calibration weighing module 43 is being calibrated, the pressure sensor 432 is disposed in the directly below the second partition of the stage 430 . That is, when the calibration weighing module 43 is automatically calibrated, the liquid collection tank 42 is separated from the weighing pan, and the customized weight 431 is connected to the weighing pan. When the calibration weighing module 43 is weighed, the customized weight 431 is separated from the weighing pan, and the liquid is collected. Tank 42 is connected to the weighing pan.
  • a first through hole is formed in the first section of the stage 430, the annular protrusion of the collection tank passes through the first through hole, and there is a certain gap between the annular protrusion of the collection tank and the first through hole
  • the outer diameter of the annular protrusion of the collection tank is smaller than the diameter of the first through hole
  • the annular protrusion of the collection tank matches the head of the weighing pan, so that when the weighing module 43 is calibrated for weighing, the weighing pan The head is embedded in the annular protrusion of the collection tank and does not contact the first through hole, or the annular protrusion of the collection tank is embedded in the head of the weighing pan and does not contact the first through hole, that is, the weighing pan only supports the liquid collection tank 42, In turn, the pressure sensor weighs the liquid collection tank 42 .
  • the second partition is provided with a second through hole
  • the bottom of the custom weight 431 is provided with a weight annular protrusion
  • the weight annular protrusion passes through the second through hole
  • the weight annular protrusion and the second through hole are connected to each other.
  • the outer diameter of the annular protrusion of the weight is smaller than the diameter of the second through hole
  • the annular protrusion of the weight matches the head of the weighing pan, so that the weighing module 43 is calibrated during calibration.
  • the head of the weighing pan is embedded in the annular protrusion of the weight and does not contact the second through hole, or the annular protrusion of the weight is embedded in the head of the weighing pan and does not contact the second through hole, that is, the weighing pan only supports the customized The weight 431 thus completes the calibration.
  • the lift mechanism 433 includes a lift motor and a lead screw, and the lift mechanism 433 drives the stage 430 to move away from or close to the pressure sensor 432 in the vertical direction.
  • the lead screw is connected with the stage 430, and the lift motor is connected with the lead screw.
  • the rotating motor 434 cooperates with the lifting mechanism 433 to switch the liquid collection tank and the customized weight 431 on the pressure sensor, so that the liquid in the liquid collection tank can be weighed and calibrated with the customized weight 431 .
  • the rotating motor is connected with the object stage 430, and the rotating motor 434 is used to drive the object stage 430 to rotate in the horizontal plane.
  • the calibration weighing module 43 performs automatic calibration before weighing the dialysis fluid collected in the fluid collection tank 42 . That is, the calibration weighing module is used to control the conditions and procedures set in the display module 44 according to the flow feedback, and calibrate the weighing module before it enters the weighing procedure. In one embodiment, the calibration weighing module can be calibrated according to the flow rate. Set the interval for timed weighing. In one embodiment, the weighing accuracy of the weighing calibration module is within a range of ⁇ 0.003g.
  • the calibration process only needs to be performed at the beginning of each day.
  • the lifting mechanism 433 lifts the stage 430 in the vertical direction so that the liquid collection tank 42 is separated from the weighing pan head Then, the motor 434 is rotated to rotate the stage 430, so that the second section of the stage 430 is located above the pressure sensor 432, the flow feedback control display module 44 makes the pressure sensor 432 automatically zero, and then the lifting mechanism 433 makes the stage 430 Descending in the vertical direction to the weight ring protrusion of the custom weight 431 embedded in the head of the weighing pan, that is, the weighing pan supports the custom weight 431, and the pressure sensor transmits the measured signal to the flow feedback control display module 44, so that the flow feedback The control display module 44 completes the calibration according to the internal instructions.
  • the flow feedback control display module when the stage is raised and the weighing pan is empty, the flow feedback control display module will automatically reset the pressure sensor to zero, and when the stage is lowered, the weighing pan is embedded in the custom weight 431 and the bottom of the weight ring protrudes The through hole of the stage will form a completely separated gap from the weighing pan and the bottom of the weight.
  • the flow feedback control display module reads the processed data of the pressure sensor signal, and completes the calibration according to the internal instructions.
  • the calibration weighing module 43 performs weighing, the lifting mechanism 433 lifts the stage 430 in the vertical direction so that the customized weight 431 is separated from the head of the weighing pan, and then the motor 434 is rotated to rotate the stage 430, so that the The first section of the stage 430 is located above the pressure sensor 432.
  • the flow feedback control display module 44 automatically resets the pressure sensor 432 to zero, and then the lifting mechanism 434 lowers the stage 430 in the vertical direction until the head of the weighing pan is embedded in the collection tank.
  • the annular protrusion that is, the weighing pan supports the liquid collection tank, and the pressure sensor transmits the measured signal to the flow feedback control display module 44 , and the measured signal is processed and displayed on the display screen of the flow feedback control display module 44 .
  • the calibration weighing module also includes a pressure sensor, and the pressure sensor is weighed through the connected weighing pan.
  • the flow feedback control display module will make the pressure sensor automatically Return to zero, when the stage is lowered, the weighing pan is embedded in the annular protrusion of the liquid collection tank to hold the liquid collection tank, and the first through hole of the stage will be completely formed with the weighing pan and the bottom of the liquid collection tank.
  • the flow feedback control display module makes the signal of the pressure sensor process and display the corresponding data on the display screen.
  • the signal processor is used to receive the signal data from the pressure sensor, process the received signal data, and then display the corresponding data on the display screen. It should be noted that the signal processor simultaneously receives the instructions from the controller, and executes various instructions such as clearing, calibrating, and reading the pressure sensor signal.
  • the controller is used to control the actions of each component of the flow feedback device, such as controlling the calibration scale The lifting mechanism in the heavy module and the action of turning the motor.
  • the automatic liquid discharge mechanism 45 is used to discharge the liquid in the liquid collection tank 42 .
  • the automatic liquid discharge mechanism 45 includes a liquid discharge pipe 451 and a liquid discharge pump 452.
  • the flow feedback control display module 44 will make the lifting mechanism 433 and the rotating motor. 434 cooperate to insert the drain pipe 451 into the liquid collection tank 42 , and start the drain pump 452 to drain the liquid in the liquid collection tank 42 .
  • a discharge pipeline is also provided, and the discharge pipeline passes through the outer cover to form an external liquid interface.
  • the connecting needle 44 is arranged on the outer cover 40 and connected to the outlet of the second connecting pipe.
  • the liquid collection tank 42, the calibration weighing module 43, the automatic discharge The liquid mechanisms 45 are all provided in the housing 40 .
  • the automatic liquid discharge mechanism 45 is arranged adjacent to the lifting mechanism 433 .
  • the flow feedback device 4 further includes a base 46 , a liquid collection tank 42 , a calibration weighing module 43 , and an automatic liquid discharge mechanism 45 are arranged above the base 46 .
  • the signal processor and the controller are arranged in the base 5 located under the stage.
  • the automatic liquid discharge mechanism 45 and the calibration weighing module 43 can operate independently.
  • the time gap between the end of the previous weighing and the beginning of the next weighing is sufficient for automatic liquid discharge, during the intermittent weighing execution process, once it is found that the accumulated liquid reaches the limit value, the automatic liquid discharge can be executed immediately. If the gap time between the two weighing actions is not enough to discharge the liquid, the weighing will be suspended for a while, and then continue after the liquid discharge is completed.
  • the flow feedback control display module can perform parameter setting and action control for the calibration weighing module 43 and the automatic liquid discharge mechanism.
  • the flow feedback display module also includes a display screen, which is used to display the current liquid weight value and the difference value of the weighing sample for the user to monitor the liquid weight change in real time. Therefore, users can view the flow trend graph of the micro-flow pipeline in real time through the monitoring screen to determine the relative stable state of the pipeline.
  • the flow feedback control and display module 44 of the flow feedback device 4 may further include an alarm module, which sends an alarm signal to the user when the weighing sampling difference is not equal to a predetermined value.
  • the system is fully automatic during the use of the equipment. As long as the communication line is connected to the host and the collection of liquid effluent is connected to the micro-flow pipeline, it can be started and operated in the equipment control.
  • the flow rate of a single pump needs to be measured.
  • the flow rate of the pump When we set the flow rate of the pump to be 5ul/min, we can observe the [weighing sampling difference] in a stable state, because the program It is fixed to perform automatic weighing every 2 minutes.
  • the weighing error of this weighing system is up to ⁇ 0.003g, so the water output every two minutes should be 0.010 ⁇ 0.003g.
  • the collection of liquid is based on the principle of self-weight of droplets, which means that each droplet should be the same weight in the same environment, so as long as each data is in the range of 0.010 ⁇ 0.003g
  • the internal change indicates that the flow rate is stable.
  • the liquid collection method is novel and unique and the structure of the liquid collection tank is unique;
  • the continuous working time is required, and the range can be satisfied within the range of 0.000g to 199.999g;
  • the interval time of automatic weighing can be freely set within the range of 10 seconds to 999 seconds according to the intermittent duration of liquid discharge;
  • ModbusTCP ModbusRTU
  • Computer connection RS485 serial port or Ethernet interface (for user software).
  • Measurement conditions are required: the wind speed of the weighing part is below 0.1m/s, the indoor temperature change range cannot exceed 0.2°C for 15 minutes, the natural volatilization of the liquid can be measured with constant humidity, and there is no abnormal vibration interference, no electrostatic interference, and no electromagnetic interference.
  • the present invention uses the principle of microdialysis technology that how much liquid is pumped in under normal conditions must discharge the same amount of liquid, a flow feedback device is installed at the end of the pipeline, and the liquid collection tank of the flow feedback device is periodically weighed. Weight measurement; once there is a sudden change in the regular change trend of the weighing data, it will immediately alarm, and the following faults can be analyzed and judged accordingly: (1) Whether the probe or connecting pipe is blocked; (2) Whether the pipeline is leaking or leaking gas; (3) Whether the syringe is not installed properly;
  • the present invention performs arithmetic statistics on the weighing data, and under special circumstances, problems can be found through pre-checking, and new variables or coefficients can be added to make the weighing result more accurate;
  • the calibration weighing module of the flow feedback device of the microdialysis system of the present invention can realize calibration before weighing, and the flow feedback device integrates an automatic drainage mechanism, that is, no personnel need to open the casing (cover) after the device is turned on. Do any calibration and pouring of liquid, the equipment can work in a continuous closed state, try to ensure no interference, less volatilization to improve accuracy;
  • the communication status between the device and the host computer is displayed in the computer or man-machine dialogue operation interface: normal or abnormal;
  • microdialysis system including the flow feedback device:
  • Liquid collection tank 1 in quantity, the material can be designed and customized according to the requirements (if the accumulated liquid needs to be collected continuously for a long time, the liquid can be automatically drained to the outside of the machine after reaching a certain amount);
  • Weight 1 piece, material stainless steel, weight can be customized
  • the micro-flow pipeline of the micro-dialysis system including the flow feedback device of the present invention may have problems such as liquid blockage caused by adsorption of the detection substance or particle blockage, or individual joints falling off when left unattended in a long-term experiment;
  • the microdialysis technology of the microdialysis system including the flow feedback device of the present invention is based on the principle that how much liquid is pumped in the normal state must discharge the same amount of liquid, the flow feedback device is installed at the end of the pipeline, and the liquid collection tank is The liquid in the tester is weighed regularly; the regular change trend of the weighing data will immediately alarm once a sudden change occurs, and the following faults can be analyzed and judged accordingly: (1) Whether the probe or connecting pipe is blocked; (2) Whether the pipeline is leaking Air leakage; (3) Whether the syringe is not installed properly;
  • the flow feedback device of the present invention has a compact and simple structure, and can check the flow trend diagram of the micro-flow pipeline through the monitoring screen to determine the relative stable state of the pipeline;
  • the weighing calibration module in the flow feedback device of the present invention can realize high-precision weighing, and the flow feedback device covers its liquid collection tank, weighing calibration module, etc. The volatilization of the liquid in the liquid collection tank is avoided and the weighing accuracy is improved;
  • the connecting needle of the flow feedback device of the present invention, the liquid collection tank, the calibration weighing module, the signal processor and controller of the flow feedback control display module, and the automatic liquid discharge mechanism are integrated in the housing, so that the flow rate of the present invention is
  • the feedback device has a compact structure, small space and volume, and is easy to place and use.

Landscapes

  • Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Water Supply & Treatment (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • External Artificial Organs (AREA)

Abstract

一种包括流量反馈装置(4)的微透析系统，包括：输入装置(1)、第一连接管路(2)、第二连接管路(3)以及流量反馈装置(4)；流量反馈装置(4)包括连接针头(41)、液体收集罐(42)、校准称重模块(43)以及流量反馈控制显示模块(44)；校准称重模块(43)用于根据流量反馈控制显示模块(44)中设定的条件和程序定时测量液体收集罐(42)的液体的重量并将测量的液体称重值传递给流量反馈控制显示模块(44)；流量反馈控制显示模块(44)将当前液体称重值与上一次液体称重值作差从而得到称重采样差值，并将称重采样差值与预定值作比较，从而监测连接针头(41)是否正常出液，进而反馈出第一连接管路(2)和第二连接管路(3)内流体流量的状态；该微透析系统通过对收集的液体的称重，监控微透析系统的连接管路的流量状态。

Description

一种包括流量反馈装置的微透析系统 技术领域
本发明涉及医疗设备领域，特别涉及一种包括流量反馈装置的微透析系统。
背景技术
由于有很多微透析实验/治疗每次都需要长时间透析(几个小时以上)，有的需要对收集到的透析液进行的在线分析监测，在微透析实验/治疗中常常会出现一下情况：(1)微透析探针或者连接管路堵塞；(2)连接管路漏液漏气；(3)注射器安装不到位等情况，这样对整个连接管及配套设备是否正常运行就需要一个及时的监视、判定、报警装置来辅助实验/治疗。
然而，在微流量的流速在现有输送管路中，现有技术没有可实时精确测定管内流速的传感器或装备。另外，当透析液经过化学分析以后，特别是一些结合在线分析的装置反应后，其液体往往含有有毒有害物质需要进行无接触式的液体收集及处理。
因此，本领域急需开发一种包括流量反馈装置的微透析系统，该微透析系统通过对收集的液体的称重，可以监控微透析系统的连接管路的流量状态，并且该系统集成了液体收集和自动排液功能。
发明内容
本发明的目的在于提供一种包括流量反馈装置的微透析系统，该微透析系统通过对收集的液体的称重，可以监控微透析系统的连接管路的流量状态，并且该系统集成了液体收集和自动排液功能。
本发明提供了一种包括流量反馈装置的微透析系统，包括：
输入装置、第一连接管路、第二连接管路以及流量反馈装置；所述流量反馈装置包括连接针头、液体收集罐、校准称重模块、以及流量反馈控制显示模块；
其中，所述输入装置包括微流量泵和注射器，所述微流量泵将可透析介质通过注射器泵送至第一连接管路中；
所述第一连接管路的一端与所述注射器流体连接，所述第一连接管路的另一端与微透析探针入口流体连接，所述第一连接管路用于将可透析物质输送至微透析探针，从而所述可透析物质通过微透析探针进入生物活体；
所述第二连接管路用于将来自生物活体的透析液体输送到所述流量反馈装置 中，所述第二连接管路的一端与微透析探针出口流体连接，所述第二连接管路的另一端与所述连接针头流体连接；
所述液体收集罐设置于所述连接针头的下方并用于收集来自生物活体的透析液体；
所述校准称重模块用于根据所述流量反馈控制显示模块中设定的条件和程序定时测量所述液体收集罐的液体的重量并将测量的液体称重值传递给所述流量反馈控制显示模块；
所述流量反馈控制显示模块将当前液体称重值与上一次液体称重值作差从而得到称重采样差值，并将称重采样差值与预定值作比较，从而监测所述连接针头是否正常出液，进而反馈出所述第一连接管路和第二连接管路内流体流量的状态。
在另一优选例中，所述来自生物活体的透析液体选自下组：经过微透析的生物活体的透析液体、透析液体经过生化反应后形成的液体、或其组合。
在另一优选例中，所述流量反馈显示模块还包括显示屏，所述显示屏用于显示当前液体称重值和称重采样差值以供用户监控液体重量变化。
在另一优选例中,所述流量反馈装置的流量反馈控制显示模块还可包括报警模块，当所述称重采样差值不等于预定值时，所述报警模块向用户发出报警信号。
在另一优选例中，所述校准称重模块在对液体收集罐内收集的透析液体称重之前，先进行自动校准。
在另一优选例中，所述校准称重模块包括载物台、压力传感器、举升机构和转动电机，所述压力传感器和所述转动电机设置在所述载物台下方，所述举升机构设置在所述载物台的侧面。
在另一优选例中，所述校准称重模块包括载物台，所述载物台包括第一分区和第二分区，所述液体收集罐设置在所述第一分区上，在所述第二分区上设置有定制砝码。
在另一优选例中，所述载物台为L型载物台。
在另一优选例中，所述校准称重模块还包括压力传感器，所述压力传感器设置在所述载物台的下方。
在另一优选例中，在所述校准称重模块进行称重时，所述压力传感器设置在所述载物台的第一分区的正下方；当所述校准称重模块进行校准时，所述压力传感器设置在所述载物台的第二分区的正下方。
在另一优选例中,所述压力传感器上连接有秤盘，在所述校准称重模块自动校 准时，所述液体收集罐与所述秤盘分离。
在另一优选例中，所述校准称重模块还包括举升机构，所述举升机构包括举升电机和丝杠，所述举升机构带动所述载物台在竖直方向远离或靠近所述压力传感器运动。
在另一优选例中，所述丝杠与所述载物台连接，所述举升电机与所述丝杠连接。
在另一优选例中，所述校准称重模块还包括转动电机，所述转动电机与所述载物台连接，所述转动电机用于带动所述载物台在水平平面内转动。
在另一优选例中，所述校准称重模块还包括转动电机，所述转动电机配合所述举升机构可在压力传感器上切换所述液体收集罐和定制砝码，实现对液体收集罐中的液体进行称重和用定制砝码进行校准。
在另一优选例中，所述压力传感器上连接有秤盘，所述秤盘包括秤盘头部；
所述载物台的第一分区设有第一通孔，所述液体收集罐的底部设有收集罐环形凸出部，所述收集罐环形凸出部穿过所述第一通孔且所述收集罐环形凸出部与所述第一通孔之间具有一定间隙，在校准称重模块进行称重时，所述秤盘头部嵌入所述收集罐环形凸出部。
在另一优选例中，所述液体收集罐包括罐口和罐体，所述收集罐环形凸出部设置在所述罐体的底部，所述罐口直径远小于罐体的直径。
在另一优选例中，所述第二分区设有第二通孔，所述定制砝码的底部设有砝码环形凸出部，所述砝码环形凸出部穿过所述第二通孔且所述砝码环形凸出部与所述第二通孔之间具有一定间隙，在校准称重模块在进行校准时，所述秤盘头部嵌入所述砝码环形凸出部。
在另一优选例中，所述校准称重模块在进行校准时，所述举升机构在竖直方向抬高所述载物台使得所述液体收集罐脱离所述所述秤盘头部，然后所述转动电机旋转所述载物台，使得所述载物台第二分区位于所述压力传感器上方，所述流量反馈控制显示模块使所述压力传感器自动归零，接着所述举升机构使所述载物台在竖直方向下降到所述定制砝码的砝码环形凸出部嵌入所述秤盘头部(即所述秤盘托住所述定制砝码，所述压力传感器将测量的信号传递给所述流量反馈控制显示模块，从而所述流量反馈控制显示模块根据内部指令完成校准。
在另一优选例中，在完成校准时，所述校准称重模块进行称重，所述举升机构在竖直方向抬高所述载物台使得所述定制砝码脱离所述秤盘头部，然后所述转 动电机旋转所述载物台，使得所述载物台第一分区位于所述压力传感器上方，所述流量反馈控制显示模块使所述压力传感器自动归零，接着所述举升机构使所述载物台在竖直方向下降到所述收集罐环形凸出部嵌入所述秤盘头部(即所述秤盘托住所述液体收集罐)，所述压力传感器将测量的信号传递给所述流量反馈控制显示模块，所述测量的信号经过处理在所述流量反馈控制显示模块的显示屏上显示。
在另一优选例中，所述流量反馈控制显示模块包括信号处理器和控制器。
在另一优选例中，所述信号处理器用于将压力传感器发生的电压信号进行模拟量转数字量，所述信号处理器同时接收控制器发来的指令，并执行清零，校准，读取压力传感器信号等多种指令，所述控制器用于控制校准称重模块中的举升机构以及转动电机的动作。
在另一优选例中，所述流量反馈控制显示模块包括用于采样值的计算、显示、参数修改、报警等的上位机。
在另一优选例中，所述校准称重模块还包括压力传感器，所述压力传感器通过连接的秤盘进行称重，当载物台升高，秤盘上为空时，流量反馈控制显示模块将使压力传感器自动归零，当载物台下降，秤盘嵌入液体收集罐的收集罐环形凸出部托住液体收集罐，载物台的通孔将与秤盘及液体收集罐罐底部形成完全分离的间隙，此时流量反馈控制显示模块使压力传感器的信号经过处理在显示屏上显示相应的数据。
在另一优选例中，所述定制砝码底部也带有砝码环形凸出部，当载物台升高，秤盘上为空时，流量反馈控制显示模块将使压力传感器自动归零，当载物台下降，秤盘嵌入定制砝码环形凸出部托住定制砝码，载物台的通孔将和秤盘及定制砝码底部形成完全分离的间隙，流量反馈控制显示模块的信号处理器接收压力传感器的信号数据，然后根据控制器的指令完成校准。
在另一优选例中,所述流量反馈装置还包括外罩，所述连接针头设置在所述外罩上，所述液体收集罐、校准称重模块设置在所述外罩内。
在另一优选例中，所述流量反馈装置还包括自动排液机构，所述自动排液机构流量反馈装置用于将所述液体收集罐中的液体排出。
在另一优选例中，所述流量反馈装置还包括底座，所述液体收集罐、校准称重模块、以及自动排液机构设置在所述底座的上方。
在另一优选例中，所述流量反馈装置为便携式。
在另一优选例中，为了使所述流量反馈装置紧凑布置，所述信号处理器和控 制器设置在所述底座中。
在另一优选例中,所述自动排液机构包括排液泵和排液管，当所述液体收集罐中的液体的称重值达到最大设定阈值时，流量反馈控制显示模块将使举升机构和转动电机配合，使所述排液管插入液体收集罐，启动排液泵将所述液体收集罐中的液体排出。
在另一优选例中,所述自动排液机构与所述校准称重模块独立运行。
在另一优选例中,所述称重校准模块的称重精度±0.003g范围内。
在另一优选例中,所述微流量泵通过指定的注射器和连接管路的速度为0.05uL/min-30uL/min。
在另一优选例中,所述校准称重模块可根据流速设定定时称重的间隔。
在另一优选例中，所述校准称重模块用于根据流量反馈控制显示模块中设定的条件和程序，在校准称重模块进入称重程序前对其进行校准。
在另一优选例中，所述流量反馈控制显示模块可对校准称重模块和自动排液机构进行参数设定和动作控制。
在另一优选例中，在医用环境下所述连接针头、第一、第二连接管路以及注射器都是一次性的。
在另一优选例中，所述微透析系统还包括其他连接管路。
应理解，在本发明范围内中，本发明的上述各技术特征和在下文(如实施例)中具体描述的各技术特征之间都可以互相组合，从而构成新的或优选的技术方案。限于篇幅，在此不再一一累述。
附图说明
为了更清楚地说明本发明实施例或现有技术中的技术方案，下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍。应理解，下面描述中的附图仅仅是本发明的一些实施实例，本领域的普通技术人员，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的实施实例。
图1是根据本发明的包括流量反馈装置的微透析系统的示意图；
图2是根据本发明的流量反馈装置的一部分组件的示意图；
图3是根据本发明的一个实施例的流量反馈装置立体结构示意图；
图4是根据本发明的一个实施例的流量反馈装置的外罩的立体结构示意图；
图5是根据本发明的一个实施例的流量反馈装置剖面图；
图6是图5的A-A剖面的结构示意图。
各附图中，各标识如下：
1-输入装置
2-第一连接管路
3-第二连接管路
4-流量反馈装置
40-外罩
41-连接针头
42-液体收集罐
43-校准称重模块
430-载物台
431-定制砝码
432-压力传感器
433-举升机构
434-转动电机
44-流量反馈控制显示模块
45-自动排液机构
451-排液管
452-排液泵
453-排液接口
46-底座
具体实施方式
本发明人通过广泛而深入的研究，首次开发了一种包括流量反馈装置的微透析系统，通过对微透析系统管路末端的流量反馈装置的液体收集罐进行定时的称重测定，从而通过对称重数据分析计算，进而监控微透析系统的第一连接管路和第二连接管路的流量状态，能够在较短的时间内及时地发现流速变化的问题，进而可分析判断以下故障：(1)微透析探针或者连接管路是否堵塞；(2)连接管路是否漏液漏气；(3)注射器是否安装不到位等。该流量反馈装置还包括显示屏，用户可以通过监控画面，查看微流量管路的流量趋势图以判定相对的管路稳定状态， 并且该流量反馈装置还集成了自动排液机构，在液体收集罐中的液体达到最大设定阈值时将液体收集罐中的液体抽排到外部液体袋/罐中。
术语
如本文所使用的，术语“称重值”和“称重采样值”可互换使用；
需要说明的是，在本专利的申请文件中，诸如第一和第二等之类的关系术语仅仅用来将一个实体或者操作与另一个实体或操作区分开来，而不一定要求或者暗示这些实体或操作之间存在任何这种实际的关系或者顺序。而且，术语“包括”、“包含”或者其任何其他变体意在涵盖非排他性的包含，从而使得包括一系列要素的过程、方法、物品或者设备不仅包括那些要素，而且还包括没有明确列出的其他要素，或者是还包括为这种过程、方法、物品或者设备所固有的要素。在没有更多限制的情况下，由语句“包括一个”限定的要素，并不排除在包括所述要素的过程、方法、物品或者设备中还存在另外的相同要素。本专利的申请文件中，如果提到根据某要素执行某行为，则是指至少根据该要素执行该行为的意思，其中包括了两种情况：仅根据该要素执行该行为、和根据该要素和其它要素执行该行为。多个、多次、多种等表达包括2个、2次、2种以及2个以上、2次以上、2种以上。
流量反馈装置
在本发明中，提供了一种结构独特的流量反馈装置4，该装置包括外罩40、连接针头41、液体收集罐42、校准称重模块43、流量反馈控制显示模块44以及自动排液机构45，其中流量反馈控制显示模块44可包括报警模块。
液体收集罐42设置于连接针头41的下方并用于收集来自生物活体的透析液体；校准称重模块43用于根据流量反馈控制显示模块44中设定的条件和程序定时测量液体收集罐42的液体的重量并将测量的液体称重值传递给流量反馈控制显示模块44；
流量反馈控制显示模块44将当前液体称重值与上一次液体称重值作差从而得到称重采样差值，并将称重采样差值与预定值作比较，从而监测连接针头41是否正常出液，进而反馈出第一连接管路2和第二连接管路3内流体流量的状态。当所述称重采样差值不等于预定值时，报警模块向用户发出报警信号。
优选地，为了使流量反馈装置结构紧凑，便于携带，校准称重模块43包括载 物台430、定制砝码431、压力传感器432、举升机构433和转动电机434，压力传感器432和转动电机434设置在载物台430下方，举升机构433设置在载物台430的侧面。
在一实施例中，连接针头41设置在外罩40上与第二连接管的出口连接，液体收集罐42、校准称重模块43、自动排液机构45都设置在外罩40内，进一步防止外界空气进入液体收集罐42中，影响校准称重模块的精度。
在一实施例中，在医用环境下，连接针头41、第一连接管路2、第二连接管路3以及注射器都是一次性的。在一实施例中，针头的规格通常根据设定的液体流速来选择粗细型号，原则就是必须保证形成液滴的间隙时间能够确保称重校准模块完成一次称重的动作。比如0.05-0.5ul/min的流速时可选择G30的针头，5ul/min的流速可选择G23的针头，更高流速时，我们甚至可以将形成液滴的针尖部制成一个更大的平面，用以形成更大的液滴确保滴液的间隙时间足够长。
优选地，流量反馈控制显示模块44包括信号处理器和控制器，优选地，流量反馈装置4还包括底座46，所述液体收集罐42、校准称重模块43、以及自动排液机构45设置在底座46的上方，为了使所述流量反馈装置紧凑布置，信号处理器和控制器设置在底座46中。
在本发明中，液体收集由连接管末端的连接针头将微量的液体在无接触的状态下，由重力作用将滴液收集到液体收集罐中，当流体流量自动反馈系统检测到液体瓶中的液体的质量达到限定值时，自动排液机构开始工作，将液体从液体收集罐中抽排到液体袋/罐中。液体袋/罐由工作人员定期更换。
在本发明中，根据收集到的透析液/液体在指定时间内是否质量增加的量正常，或无液体排出时其停滞时间是否正常来反馈连接管内流体流量的状态(1正常/2堵液/3有泄露)，报警提示后由人员介入检查连接管及配套设备是否存在非正常的现象。
包括流量反馈装置的微透析系统
在本发明中，提供了一种包括流量反馈装置的微透析系统，该系统包括：输入装置1、第一连接管路2、第二连接管路3以及流量反馈装置4；其中，输入装置1包括微流量泵和注射器，微流量泵将可透析介质通过注射器泵送至第一连接管路2中；第一连接管路2的一端与注射器流体连接，第一连接管路2的另一端与微透析探针入口流体连接，第一连接管路2用于将可透析物质输送至微透析探 针，从而可透析物质通过微透析探针进入生物活体；第二连接管路3用于将来自生物活体的透析液体输送到流量反馈装置4中，第二连接管路3的一端与微透析探针出口流体连接，第二连接管路3的另一端与流量反馈装置4流体连接。
在一实施例中，来自生物活体的透析液体选自下组：经过微透析的生物活体的透析液体、透析液体经过生化反应后形成的液体、或其组合。在一实施例中，微流量泵通过指定的注射器和连接管路的速度为0.05uL/min-30uL/min。在一实施例中，微透析系统还包括其他连接管路。在一实施例中，在有液体(透析液体)生成的系统中第二连接管路在进入流量反馈装置前可并入更多的连接管，第二连接管路包括这些并入的连接管。
在以下的叙述中，为了使读者更好地理解本发明而提出了许多技术细节。但是，本领域的普通技术人员可以理解，即使没有这些技术细节和基于以下各实施方式的种种变化和修改，也可以实现本发明所要求保护的技术方案。
实施例
参考图1-6，本发明提供了一种包括流量反馈装置的微透析系统，该系统包括：输入装置1、第一连接管路2、第二连接管路3以及流量反馈装置4；
流量反馈装置4包括外罩40、连接针头41、液体收集罐42、校准称重模块43、流量反馈控制显示模块44以及自动排液机构45；连接针头42的规格根据约定的液体流速范围选配。
其中，输入装置1包括微流量泵和注射器，微流量泵将可透析介质通过注射器泵送至第一连接管路2中；第一连接管路2的一端与注射器流体连接，第一连接管路2的另一端与微透析探针入口流体连接，第一连接管路2用于将可透析物质输送至微透析探针，从而可透析物质通过微透析探针进入生物活体；第二连接管路3用于将来自生物活体的透析液体输送到流量反馈装置4中，第二连接管路3的一端与微透析探针出口流体连接，第二连接管路3的另一端与连接针头41流体连接；
液体收集罐42设置于连接针头41的下方并用于收集来自生物活体的透析液体；校准称重模块43用于根据流量反馈控制显示模块44中设定的条件和程序定时测量液体收集罐42的液体的重量并将测量的液体称重值传递给流量反馈控制显示模块44；
流量反馈控制显示模块44将当前液体称重值与上一次液体称重值作差从而得到称重采样差值，并将称重采样差值与预定值作比较，从而监测连接针头41是否正常出液，进而反馈出第一连接管路2和第二连接管路3内流体流量的状态。
在本实施例中，校准称重模块43包括载物台430、压力传感器432、举升机构433以及转动电机434；流量反馈控制显示模块44包括信号处理器和控制器。
液体收集罐42包括罐口和罐体，为了避免收集的液体挥发，使得称重更加精准，罐口直径被配置为远小于罐体的直径，在罐体的底部设有与校准称重模块配合的收集罐环形凸出部。
压力传感器432设置在载物台430的下方，压力传感器432上连接有秤盘，秤盘包括秤盘头部。收集罐环形凸出部作用是既可以在载物台上固定，又可以使秤盘对准收集罐环形凸出部稳定搭载液体收集罐。
载物台430包括第一分区和第二分区，液体收集罐42设置在第一分区上，定制砝码设置在第二分区上。在本实施例中，载物台430为L型。在一实施例中，在校准称重模块43进行称重时，压力传感器432设置在载物台430的第一分区的正下方；当校准称重模块43进行校准时，压力传感器432设置在载物台430的第二分区的正下方。即在校准称重模块43自动校准时，液体收集罐42与秤盘分离，定制砝码431与秤盘连接，在校准称重模块43称重时，定制砝码431与秤盘分离，液体收集罐42与秤盘连接。
在本实施例中，载物台430的第一分区设有第一通孔，收集罐环形凸出部穿过第一通孔且收集罐环形凸出部与第一通孔之间具有一定间隙，换句话说，收集罐环形凸出部的外径小于第一通孔的直径，另外收集罐环形凸出部与秤盘头部匹配，使得在校准称重模块43进行称重时，秤盘头部嵌入收集罐环形凸出部且不与第一通孔接触，或者收集罐环形凸出部嵌入秤盘头部且不与第一通孔接触，即秤盘仅托住液体收集罐42，进而压力传感器对液体收集罐42进行称重。第二分区设有第二通孔，定制砝码431的底部设有砝码环形凸出部，砝码环形凸出部穿过第二通孔且砝码环形凸出部与第二通孔之间具有一定间隙，换句话说，砝码环形凸出部的外径小于第二通孔的直径，另外砝码环形凸出部与秤盘头部匹配，使得在校准称重模块43在进行校准时，秤盘头部嵌入砝码环形凸出部且不与第二通孔接触，或者砝码环形凸出部嵌入秤盘头部且不与第二通孔接触，即秤盘仅托住定制砝码431从而完成校准。
举升机构433包括举升电机和丝杠，举升机构433带动载物台430在竖直方 向远离或靠近压力传感器432运动。丝杠与载物台430连接，举升电机与丝杠连接。
转动电机434配合举升机构433可在压力传感器上切换液体收集罐和定制砝码431，实现对液体收集罐中的液体进行称重和用定制砝码431进行校准。转动电机与载物台430连接，转动电机434用于带动载物台430在水平平面内转动。
校准称重模块43在对液体收集罐42内收集的透析液体称重之前，先进行自动校准。即校准称重模块用于根据流量反馈控制显示模块44中设定的条件和程序，在校准称重模块进入称重程序前对其进行校准，在一实施例中，校准称重模块可根据流速设定定时称重的间隔。在一实施例中，所述称重校准模块的称重精度±0.003g范围内。
在本实施例中，校准过程只需要在每天的一开始进行，校准称重模块43在进行校准时，举升机构433在竖直方向抬高载物台430使得液体收集罐42脱离秤盘头部，然后转动电机434旋转载物台430，使得载物台430第二分区位于压力传感器432上方，流量反馈控制显示模块44使压力传感器432自动归零，接着举升机构433使载物台430在竖直方向下降到秤盘头部嵌入定制砝码431的砝码环形凸出部即秤盘托住定制砝码431，压力传感器将测量的信号传递给流量反馈控制显示模块44，从而流量反馈控制显示模块44根据内部指令完成校准。
换句话说，当载物台升高，秤盘上为空时，流量反馈控制显示模块将使压力传感器自动归零，当载物台下降，秤盘嵌入定制砝码431底部砝码环形凸出部托住砝码，载物台的通孔将和秤盘及砝码底部形成完全分离的间隙，流量反馈控制显示模块读取压力传感器的信号经过处理的数据，根据内部指令完成校准。
在完成校准时，校准称重模块43进行称重，举升机构433在竖直方向抬高载物台430使得定制砝码431脱离秤盘头部，然后转动电机434旋转载物台430，使得载物台430第一分区位于压力传感器432上方，流量反馈控制显示模块44使压力传感器432自动归零，接着举升机构434使载物台430在竖直方向下降到秤盘头部嵌入收集罐环形凸出部即秤盘托住液体收集罐，压力传感器将测量的信号传递给流量反馈控制显示模块44，测量的信号经过处理在流量反馈控制显示模块44的显示屏上显示。
在本实施例中，校准称重模块还包括压力传感器，压力传感器通过连接的秤盘进行称重，当载物台升高，秤盘上为空时，流量反馈控制显示模块将使压力传感器自动归零，当载物台下降，秤盘嵌入液体收集罐罐收集罐环形凸出部从而托 住液体收集罐，载物台的第一通孔将和秤盘及液体收集罐罐体底部形成完全分离的间隙，此时流量反馈控制显示模块使压力传感器的信号经过处理在显示屏上显示相应的数据。
在本实施例中，信号处理器用于接收来自压力传感器的信号数据，并将接收的信号数据进行处理，进而在显示屏上显示相应的数据。需要说明的是，信号处理器同时接收控制器发来的指令，并执行清零，校准，读取压力传感器信号等多种指令，控制器用于控制流量反馈装置各个组件的动作，例如控制校准称重模块中的举升机构以及转动电机的动作。
自动排液机构45用于将液体收集罐42中的液体排出。自动排液机构45包括排液管451和排液泵452，当液体收集罐42中的液体的称重值达到最大设定阈值时，流量反馈控制显示模块44将使举升机构433和转动电机434配合，使排液管451插入液体收集罐42，启动排液泵452将液体收集罐42中的液体排出。在本实施例中，还设有排出管路，排出管路穿过外罩形成液体外部接口。
为了进一步防止外界空气进入液体收集罐42中，影响校准称重模块的精度，连接针头44设置在外罩40上与第二连接管的出口连接，液体收集罐42、校准称重模块43、自动排液机构45都设置在外罩40内。优选地，为了流量反馈装置4的结构紧凑，自动排液机构45紧邻举升机构433设置。
流量反馈装置4还包括底座46，液体收集罐42、校准称重模块43、以及自动排液机构45设置在底座46的上方。为了使流量反馈装置结构设置更加紧凑，信号处理器和控制器设置在位于载物台下方的底座5中。
需要说明的是，在本发明的自动排液机构45与校准称重模块43可独立运行。当前一次称重结束到后一次称重开始，其间的时间间隙足以进行自动排液的动作时，可以在间歇的称重执行过程中，一旦发现积液达到极限值，马上执行自动排液。如果两次称重动作中间的间隙时间不够排液的，称重会暂停一会，等排液结束以后再继续。
流量反馈控制显示模块可对校准称重模块43和自动排液机构进行参数设定和动作控制。流量反馈显示模块还包括显示屏，显示屏用于显示当前液体称重值和称重采样差值以供用户实时监控液体重量变化。因此用户可以通过监控画面，实时查看微流量管路的流量趋势图以判定相对的管路稳定状态。
在本实施例中，流量反馈装置4的流量反馈控制显示模块44还可包括报警模块，当所述称重采样差值不等于预定值时，报警模块向用户发出报警信号。
校准称重模块的操作说明：
本系统在该设备使用过程中为全自动工作，只要和主机连接好通讯线，和微流量管路连接好液体出水的收集，即可在设备控制中开启运行。
通过校准称重模块的实时数据，判定流速的方法
设备刚刚运行时，由于微流量泵快进使得注射器内部及管子内部的压强较大，需要大约15-30分钟的时间去释放完内部过高压力后，流速才会趋于稳定。
所以一般我们在15分钟以后观测[称重采样差值]的变化情况。
举例说明，假设管内的液体是纯水，密度1.0，需要测定单个泵的流速，当我们设定泵的流速是5ul/min时，可以在稳定状态下观察[称重采样差值]，因为程序是固定在每2分钟进行一次自动称重，该称重系统的称重误差最高±0.003g,所以每两分钟的出水量应该是0.010±0.003g。虽然称重系统存在误差，但是液体的采集是利用液滴的自重原理收集的，也就是说每一滴液滴在同样环境下应该是一样重的，所以只要每一次数据都在0.010±0.003g范围内变化，就说明流速是稳定的。
当然更精准的流速测算，还需要更长的时间段，通过在一个小时或者几个小时内总的出水量/时间去计算平均流速。
这样当流速需要微调时，我们可以按照最小一个脉冲的单位慢慢调节流速。
校准称重模块的特点
(1)液体的采集方式新颖独特并且液体收集罐的结构独特；
(2)根据排液量，要求连续的工作时长，量程范围0.000g到199.999g内可满足；
(3)可根据排液的间歇性时长，在10秒到999秒范围内自由设定自动称重的间隔时间；
(4)开机后系统可自动执行用砝码校准；
(5)每次称重前都执行自动归零；
(6)最高称重精度±0.003g，相对标准偏差(RSD)<0.01％；
(7)可支持的外部通讯：ModbusTCP或ModbusRTU电脑连接：RS485串口或以太网接口(用于用户软件)。
*备注：测定条件要求：称重部的风速0.1m/s以下，室内温度变化范围15分钟不能超过0.2℃，湿度恒定液体自然挥发量可测，没有异常振动干扰，没有静电 干扰、电磁干扰。
包括流量反馈装置的微透析系统的功能特点有：
(a)本发明通过利用微透析技术在正常状态下泵入多少液体必然排出等量液体的原理，在管路的末端安装了流量反馈装置，对此流量反馈装置的液体收集罐进行定时的称重测定；在称重数据有规律的变化趋势一旦发生突变立即报警，依此可分析判断以下故障：(1)探头或者连接管是否堵塞；(2)管路是否漏液漏气；(3)注射器是否安装不到位；
(b)本发明对称重数据进行运算统计，特殊环境下还可以通过预检发现问题，加入新的变量或系数，可使得称重的结果更加精确；
(c)本发明的微透析系统的流量反馈装置的校准称重模块，可以实现在称重前进行校准，并且流量反馈装置集成了自动排液机构，即设备开机后无需人员打开外壳(外罩)做任何校准、倒积液的工作，设备可在持续封闭状态下工作，尽量确保无干扰，少挥发来提高精度；
(d)通过电脑或者人机对话操作界面操作运行；电脑或者人机对话操作界面里显示设备运行的状态：待机、自动校准、运行中、报警异常；
电脑或者人机对话操作界面里显示设备与上位机的通讯状态：正常，或者异常；
(e)配套用户软件，参数可变更，数据可保存。
包括流量反馈装置的微透析系统的其他技术参数：
液体收集罐：数量1只，材质可根据要求设计定制(需要长时间连续收集积液的可通过自动排液功能，在达到一定量后自动排液到机子外面)；
砝码：数量1只，材质不锈钢，重量可定制；
工作温度：10-35℃；
电机：步进电机系统；
电压：DC24V；
功耗：最大50W；
尺寸：120x120x180mm(长x宽x高)；
重量：约2KG。
本发明的主要优点
(a)本发明的包括流量反馈装置的微透析系统的可以监控微流量管路可能存在由于检测物质吸附或者颗粒阻塞引起的堵液或者长时间实验中无人看管时个别接头处脱落等问题；
(b)本发明的包括流量反馈装置的微透析系统的微透析技术在正常状态下泵入多少液体必然排出等量液体的原理，在管路的末端安装了流量反馈装置，对此液体收集罐中的液体进行定时的称重测定；称重数据有规律的变化趋势一旦发生突变立即报警，依此可分析判断以下故障：(1)探头或者连接管是否堵塞；(2)管路是否漏液漏气；(3)注射器是否安装不到位；
(c)本发明的流量反馈装置结构紧凑简单、并且可以通过监控画面，查看微流量管路的流量趋势图以判定相对的管路稳定状态；
(d)本发明的流量反馈装置中的称重校准模块能够实现高精度称重，并且该流量反馈装置通过外罩将其液体收集罐、称重校准模块等罩住不受外界空气的干扰，也避免了液体收集罐中的液体的挥发进而提高了称重精度；
(e)本发明的流量反馈装置的连接针头、液体收集罐、校准称重模块、流量反馈控制显示模块的信号处理器和控制器以及自动排液机构集成在外罩内，从而使得本发明的流量反馈装置结构紧凑，空间体积小，便于放置和使用。
在本发明提及的所有文献都被认为是整体性地包括在本发明的公开内容中，以便在必要时可以作为修改的依据。此外应理解，在阅读了本发明的上述公开内容之后，本领域技术人员可以对本发明作各种改动或修改，这些等价形式同样落于本发明所要求保护的范围。

Claims (10)

  1. 一种包括流量反馈装置的微透析系统，其特征在于，包括：
    输入装置(1)、第一连接管路(2)、第二连接管路(3)以及流量反馈装置(4)；所述流量反馈装置(4)包括连接针头(41)、液体收集罐(42)、校准称重模块(43)、以及流量反馈控制显示模块(44)；
    其中，所述输入装置(1)包括微流量泵和注射器，所述微流量泵将可透析介质通过注射器泵送至第一连接管路(2)中；
    所述第一连接管路(2)的一端与所述注射器流体连接，所述第一连接管路(2)的另一端与微透析探针入口流体连接，所述第一连接管路(2)用于将可透析物质输送至微透析探针，从而所述可透析物质通过微透析探针进入生物活体；
    所述第二连接管路(3)用于将来自生物活体的透析液体输送到所述流量反馈装置中，所述第二连接管路(3)的一端与微透析探针出口流体连接，所述第二连接管路(3)的另一端与所述连接针头(41)流体连接；
    所述液体收集罐(42)设置于所述连接针头(41)的下方并用于收集来自生物活体的透析液体；
    所述校准称重模块(43)用于根据所述流量反馈控制显示模块(44)中设定的条件和程序定时测量所述液体收集罐(42)的液体的重量并将测量的液体称重值传递给所述流量反馈控制显示模块(44)；和
    所述流量反馈控制显示模块(44)将当前液体称重值与上一次液体称重值作差从而得到称重采样差值，并将称重采样差值与预定值作比较，从而监测所述连接针头(41)是否正常出液，进而反馈出所述第一连接管路(2)和第二连接管路(3)内流体流量的状态。
  2. 如权利要求1所述的微透析系统，其特征在于,所述校准称重模块(43)包括载物台(430)，所述载物台(430)包括第一分区和第二分区，所述液体收集罐(42)设置在所述第一分区上，在所述第二分区上设置有定制砝码(431)。
  3. 如权利要求2所述的微透析系统，其特征在于,所述校准称重模块(43)还包括压力传感器(432)，所述压力传感器(432)设置在所述载物台(430)的下方。
  4. 如权利要求3所述的微透析系统，其特征在于,所述校准称重模块(43)还包括举升机构(433)，所述举升机构(433)包括举升电机和丝杠，所述举升机构带动所述载物台(430)在竖直方向远离或靠近所述压力传感器(432)运动。
  5. 如权利要求3所述的微透析系统，其特征在于,所述校准称重模块(43)还包括转动电机(434)，所述转动电机(434)与所述载物台(430)连接，所述转动电机(434)用于带动所述载物台(430)在水平平面内转动。
  6. 如权利要求3所述的微透析系统，其特征在于,所述压力传感器(432)上连接有秤盘，所述秤盘包括秤盘头部；
    所述载物台(430)的第一分区设有第一通孔，所述液体收集罐(42)的底部设有收集罐环形凸出部，所述收集罐环形凸出部穿过所述第一通孔且所述收集罐环形凸出部与所述第一通孔之间具有一定间隙，在校准称重模块(43)进行称重时，所述秤盘头部嵌入所述收集罐环形凸出部。
  7. 如权利要求6所述的微透析系统，其特征在于,所述第二分区设有第二通孔，所述定制砝码(431)的底部设有砝码环形凸出部，所述砝码环形凸出部穿过所述第二通孔且所述砝码环形凸出部与所述第二通孔之间具有一定间隙，在校准称重模块(43)在进行校准时，所述秤盘头部嵌入所述砝码环形凸出部。
  8. 如权利要求1所述的微透析系统，其特征在于,所述流量反馈装置(4)还包括外罩(45)，所述连接针头(44)设置在所述外罩(45)上，所述液体收集罐(42)、校准称重模块(43)设置在所述外罩内。
  9. 如权利要求1所述的微透析系统，其特征在于,所述流量反馈装置(4)还包括自动排液机构(45)，所述自动排液机构流量反馈装置(4)用于将所述液体收集罐(42)中的液体排出。
  10. 如权利要求9所述的微透析系统，其特征在于,所述流量反馈装置(4)还包括底座(46)，所述液体收集罐(42)、校准称重模块(43)、以及自动排液机构(45)设置在所述底座(46)的上方。
PCT/CN2022/087508 2021-04-22 2022-04-18 一种包括流量反馈装置的微透析系统 WO2022222898A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202110433208.2 2021-04-22
CN202110433208.2A CN112972803B (zh) 2021-04-22 2021-04-22 一种包括流量反馈装置的微透析系统

Publications (1)

Publication Number Publication Date
WO2022222898A1 true WO2022222898A1 (zh) 2022-10-27

Family

ID=76339795

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2022/087508 WO2022222898A1 (zh) 2021-04-22 2022-04-18 一种包括流量反馈装置的微透析系统

Country Status (2)

Country Link
CN (1) CN112972803B (zh)
WO (1) WO2022222898A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112972803B (zh) * 2021-04-22 2021-08-10 上海花涯自动化科技有限公司 一种包括流量反馈装置的微透析系统

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0403394A1 (fr) * 1989-06-16 1990-12-19 Zeta Technology Sonde de microdialyse
CN1163576A (zh) * 1994-11-14 1997-10-29 Cma精密刻度股份公司 微透析装置
US20020082490A1 (en) * 2000-08-04 2002-06-27 Josef Roeper Microdialysis system
US20070191702A1 (en) * 2006-02-15 2007-08-16 Medingo Ltd. Systems and methods for sensing analyte and dispensing therapeutic fluid
CN101703817A (zh) * 2009-11-23 2010-05-12 浙江大学 颈静脉微透析探针及探针引导装置
CN102014739A (zh) * 2008-06-05 2011-04-13 G-感觉有限公司 用于对代谢物的血液浓度实施快速反应监测的方法与系统
CN109771720A (zh) * 2019-01-23 2019-05-21 暨南大学 一种微型人工肾仪
CN111712196A (zh) * 2017-12-15 2020-09-25 葛思特克朗兹公司 用于基于留置导管的治疗的传感器监测系统
CN112972803A (zh) * 2021-04-22 2021-06-18 上海花涯自动化科技有限公司 一种包括流量反馈装置的微透析系统

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4908044B2 (ja) * 2006-04-14 2012-04-04 株式会社ジェイ・エム・エス 重量検出装置及びバランス制御装置
US8226595B2 (en) * 2006-05-26 2012-07-24 Baxter International Inc. Automated dialysis system driven by gravity and vacuum
CN103830788B (zh) * 2012-11-27 2016-02-24 深圳先进技术研究院 血液透析中心供液系统
CN103845769A (zh) * 2012-11-29 2014-06-11 珠海弘陞生物科技开发有限公司 多功能血液净化装置及使用该装置进行血液净化的方法
CN109310843A (zh) * 2016-04-27 2019-02-05 赛斯安尼股份有限公司 用于将流体和/或气体递送到肺的设备和方法
CN209519163U (zh) * 2018-01-15 2019-10-22 深圳市中医院 一种供液控制系统及腹膜透析机
CN108066836B (zh) * 2018-02-05 2021-01-05 东南大学 采用重量平衡实现流量和超滤控制的血液透析系统
CN108992725A (zh) * 2018-08-17 2018-12-14 潘岳 一种腹膜透析机
CN109357738A (zh) * 2018-10-10 2019-02-19 苏州爱力想电子科技有限公司 腹膜透析电子称的称重方法
CN110426107A (zh) * 2019-09-09 2019-11-08 苏州钮曼精密机电科技有限公司 一种称重装置及称重系统
CN110812560A (zh) * 2019-11-25 2020-02-21 中国船舶重工集团公司第七一六研究所 一种手动腹膜透析设备

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0403394A1 (fr) * 1989-06-16 1990-12-19 Zeta Technology Sonde de microdialyse
CN1163576A (zh) * 1994-11-14 1997-10-29 Cma精密刻度股份公司 微透析装置
US20020082490A1 (en) * 2000-08-04 2002-06-27 Josef Roeper Microdialysis system
US20070191702A1 (en) * 2006-02-15 2007-08-16 Medingo Ltd. Systems and methods for sensing analyte and dispensing therapeutic fluid
CN102014739A (zh) * 2008-06-05 2011-04-13 G-感觉有限公司 用于对代谢物的血液浓度实施快速反应监测的方法与系统
CN101703817A (zh) * 2009-11-23 2010-05-12 浙江大学 颈静脉微透析探针及探针引导装置
CN111712196A (zh) * 2017-12-15 2020-09-25 葛思特克朗兹公司 用于基于留置导管的治疗的传感器监测系统
CN109771720A (zh) * 2019-01-23 2019-05-21 暨南大学 一种微型人工肾仪
CN112972803A (zh) * 2021-04-22 2021-06-18 上海花涯自动化科技有限公司 一种包括流量反馈装置的微透析系统

Also Published As

Publication number Publication date
CN112972803B (zh) 2021-08-10
CN112972803A (zh) 2021-06-18

Similar Documents

Publication Publication Date Title
KR920704115A (ko) 자동식 액체 표본추출 및 검사장치 및 방법
WO2022222898A1 (zh) 一种包括流量反馈装置的微透析系统
CN107389160B (zh) 一种检测燃气表卡表的检测装置及检测方法
CN204214881U (zh) 一种自动定量加液装置
US11478751B2 (en) Automated single-use filtering apparatus, and method for controlling an automated single-use filtering apparatus
CN115090114A (zh) 过滤系统及其控制方法
CN109542130B (zh) 离子喷头流量控制系统及设备
EP2132611B1 (en) Fluid sampling system with an in-line probe
CN106052018B (zh) 中央空调冷却水加药运维控制系统及其控制方法
CN201331932Y (zh) 密度式硼浓度仪清洁及标定装置
CN212622072U (zh) 一种新型在线粘度检测系统
CN209167113U (zh) 一种基于数据采集与内部计算纠偏的总氮分析测量设备
CN201896630U (zh) 煤矿数字化防突抽采在线监测系统
US20030066346A1 (en) Chemical injection pulse generator
CN114088505A (zh) 一种水处理水质检测仪表预处理装置系统及其工作方法
CN112830598A (zh) 余氯检测加药系统
CN201507434U (zh) 实验室纯水器纯水泵测试装置
CN206381183U (zh) 尿流率仪的检测装置
CN206387478U (zh) 一种加油机流量计性能测试装置
CN110215564B (zh) 输液控制装置
CN219496362U (zh) 一种sdi值的移动检测设备
CN219935829U (zh) 一种溶解氧测量装置
JPH10185813A (ja) 濁度・色度計
CN216260048U (zh) 一种电驱动膜智能CIP系统的pH检测装置
CN108007709B (zh) 药剂注入系统专用检测装置

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 22791006

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 18287629

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 22791006

Country of ref document: EP

Kind code of ref document: A1