WO2022196157A1 - Dispositif d'analyse automatisé et procédé de confirmation de trajet d'écoulement - Google Patents

Dispositif d'analyse automatisé et procédé de confirmation de trajet d'écoulement Download PDF

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Publication number
WO2022196157A1
WO2022196157A1 PCT/JP2022/004287 JP2022004287W WO2022196157A1 WO 2022196157 A1 WO2022196157 A1 WO 2022196157A1 JP 2022004287 W JP2022004287 W JP 2022004287W WO 2022196157 A1 WO2022196157 A1 WO 2022196157A1
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Prior art keywords
liquid
automatic analyzer
unit
flow path
conductivity
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PCT/JP2022/004287
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English (en)
Japanese (ja)
Inventor
隼佑 宮本
創 山崎
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株式会社日立ハイテク
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Priority to JP2023506843A priority Critical patent/JP7535651B2/ja
Publication of WO2022196157A1 publication Critical patent/WO2022196157A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Definitions

  • the present invention relates to an automatic analyzer and its flow channel confirmation method.
  • the automatic analyzer is a device that performs quantitative and qualitative analysis of the components of biological samples (hereinafter referred to as samples) such as serum and urine using optical and electrical analysis methods.
  • samples biological samples
  • analysis methods there is a method in which a plurality of types of liquids such as samples and reagents are supplied at different timings into a flow path including an analysis unit, and the components of each liquid are analyzed. Further, in the automatic analyzer, an operation of discharging a cleaning solution obtained by combining detergent and water supplied through a common flow path is performed to clean the reaction vessel after analysis.
  • a technique using a conductivity sensor is known as a technique for measuring the physical quantity of liquid in a flow path.
  • a reagent after preparation is measured by a conductivity sensor and it is determined whether or not the measured value is within a predetermined range. (Paragraph 0095, etc.).
  • the automatic analyzer may switch the type of liquid flowing through the same flow path at a predetermined timing to supply different types of liquids to desired locations. At this time, in the current automatic analyzer, an excessive amount of liquid had to be supplied so that a specific liquid could be reliably supplied regardless of the individual differences of the apparatuses and the installation environment.
  • the purpose of the present invention is to provide an automatic analyzer that can reduce running costs by reducing the amount of reagents and detergents used and suppressing the frequency of replacement of reagent containers and detergent containers.
  • the automatic analyzer of the present invention relates to the same flow path through which a plurality of types of liquids flow, a pump that supplies the liquid to the flow path, and the liquid supplied to the flow path.
  • a measurement unit that measures a physical quantity
  • a determination unit that determines, based on the physical quantity measured by the measurement unit, that a flow channel upstream of the measurement unit has been replaced with a specific liquid.
  • an automatic analyzer that can reduce running costs by reducing the amount of reagents and detergents used and suppressing the replacement frequency of reagent containers and detergent containers.
  • FIG. 1 is an example of a schematic block diagram of an automatic analyzer for electrolyte analysis to which Embodiment 1 is applied;
  • FIG. FIG. 10 is a functional block diagram showing a configuration of a controller, in particular, a configuration related to an operation sequence for determining replacement of liquid in a channel;
  • An example of a flow chart for electrolyte analysis. 4 is a time chart showing an operation sequence of each part in the automatic analyzer according to Example 1; 4 is a time chart showing another operation sequence of each part in the automatic analyzer according to Example 1; 4 is a flowchart showing processing of a syringe pump;
  • FIG. 4 is a schematic diagram showing the structure of the conductivity measuring part and the flow path around it in Example 1;
  • FIG. 4 is a schematic diagram showing the structure of another conductivity measuring part and its peripheral flow path in Example 1; An example of a schematic configuration diagram of an automatic analyzer that performs detergent dilution to which Embodiment 2 is applied. An example of a schematic configuration diagram of a detergent dilution channel in the automatic analyzer of Example 2.
  • FIG. 4 is a flow chart showing the process from diluting the detergent with water to discharging it into the reaction container.
  • 6 is a time chart showing the operation sequence of each part in the automatic analyzer according to Example 2;
  • the automatic analyzer according to the present embodiment performs measurement for measuring physical quantities related to liquids in the same flow path to which multiple types of liquids (samples, reagents, detergents, water, etc.) are supplied at different timings during analysis or maintenance. department is provided. Then, the determination unit of the automatic analyzer according to the present embodiment determines that the inside of the flow path on the upstream side of the measurement unit has been replaced with a specific liquid, based on the physical quantity measured by the measurement unit. As a result, the amount of liquid to be fed is optimized, and an automatic analyzer capable of reducing the amount of liquid used can be provided.
  • the measurement unit measures the conductivity of the liquid in the flow channel, and when the conductivity reaches a predetermined value, the determination unit determines that the liquid in the analysis unit is the object of analysis. It is determined that the liquid has been replaced. Therefore, according to the automatic analyzer 10 of the present embodiment, the timing at which the liquid is completely replaced can be accurately determined, and the amount of excessively supplied liquid can be reduced.
  • electrolyte analysis will be described as an example of analysis.
  • a sample is supplied into a flow channel including an electrolyte analysis section, and the potential difference from a reference solution is measured as the ion concentration (electrolyte concentration) in the sample.
  • a standard solution reagent
  • a cleaning liquid is supplied into the channel at regular intervals to clean the channel and the analysis unit.
  • FIG. 1 is an example of a schematic configuration diagram of an automatic analyzer 10 that performs electrolyte analysis to which Embodiment 1 is applied.
  • the automatic analyzer 10 of this embodiment includes an analysis unit 11 and an operation unit 12. As shown in FIG. 1
  • the analysis unit 11 is a unit that analyzes requested items on the sample and outputs analysis results.
  • This analysis unit 11 includes a sample disk 102, a dilution tank 103, a diluent container 104, a cleaning solution container 105, a reagent container 106, a sample pipetting probe 107, an electrolyte analysis section 108, a syringe pump 109, A dilution pump 110 , a washing solenoid valve 115 , a reagent solenoid valve 116 , a dilution solenoid valve 117 , a suction side solenoid valve 118 , a drain side solenoid valve 119 , and a conductivity measuring section 111 are provided.
  • the reagent electromagnetic valve 116 and the dilution electromagnetic valve 117 are located upstream of the electrolyte analysis unit 108 and are electromagnetic valves that switch the liquid supplied to the flow path between the reagent and the diluted sample.
  • the suction side solenoid valve 118 is positioned downstream of the conductivity measuring section 111 and is a solenoid valve that opens and closes the flow path.
  • a sample container 101 (collection tube) is mounted on the circumference of the sample disk 102 .
  • a sample pipetting probe 107 is installed which can rotate and move up and down.
  • the sample dispensing probe 107 rotates and moves vertically to dispense the sample from the sample container 101 to the dilution tank 103 .
  • the dilution tank 103 has an open cup-shaped upper surface and a channel connected to a syringe pump 109 on its bottom surface.
  • the dilution pump 110 transfers the diluent from the diluent container 104 to the dilution tank 103 .
  • the sample and the diluent are agitated by the water pressure of the dilution pump 110 when the liquid is fed, and the sample is diluted.
  • the conductivity measurement unit 111 is a measurement unit that measures the electrical conductivity as a physical quantity related to the liquid supplied to the channel.
  • the electrolyte analysis unit 108 measures a physical quantity different from the physical quantity measured by the conductivity measurement unit in order to analyze the components of the liquid.
  • the syringe pump 109 supplies the liquid to the channel by sucking and discharging the liquid.
  • a flow path upstream of the syringe pump 109 is provided with a suction-side solenoid valve 118, a conductivity measuring section 111, an electrolyte analysis section 108, and a branch section branching in three directions in order toward the upstream. .
  • a cleaning electromagnetic valve 115 is positioned in the first direction in which the branching portion branches, and a cleaning liquid container 105 is connected to the flow path on the upstream side thereof.
  • a reagent electromagnetic valve 116 is positioned in the second direction in which the branching portion branches, and the reagent container 106 is connected to the flow path on the upstream side thereof.
  • a dilution electromagnetic valve 117 is positioned in the third direction in which the branching section branches, and the dilution pump 110 and the dilution tank 103 are connected to the upstream side thereof.
  • the operation unit 12 is a part that plays a role of controlling the information of the entire system of the automatic analyzer 10, and has a computer 112 and a controller 113.
  • the computer 112 includes a display section and an input section.
  • the display unit displays various screens such as analysis request items and analysis results.
  • the input unit is used by an operator or the like to input various parameter settings, start or stop of analysis, etc., based on the operation screen displayed on the display unit.
  • the controller 113 is connected to each mechanism within the analysis unit 11, and includes a control section, a data acquisition section, a calculation section, a determination section, and a storage section.
  • the control unit controls operations of the syringe pump 109, each solenoid valve, the electrolyte analysis unit 108, the conductivity measurement unit 111, and the like.
  • the data acquisition unit acquires data measured by the electrolyte analysis unit 108 and the conductivity measurement unit 111 .
  • the computation unit computes the electrolyte concentration in the sample to be analyzed based on the potential and the like measured by the electrolyte analysis unit 108 .
  • the determination unit determines whether or not the flow path on the upstream side of the conductivity measurement unit 111 has been replaced with a specific liquid.
  • the storage unit stores time charts and operation parameters necessary for the operation of each mechanism, various information on samples, diluents, reagents, and cleaning solutions, analysis results, as well as calculations using the electrolyte analysis unit 108 and the conductivity measurement unit 111. Stores reference data and the like used for determination.
  • FIG. 2 is a functional block diagram showing the configuration of the controller 113, particularly related to the operation sequence for determining replacement of the liquid in the channel.
  • the controller 113 pre-stores a conductivity data acquisition unit 131 that acquires conductivity measurement data from the conductivity measurement unit 111, and a conductivity reference data of the liquid supplied into the channel.
  • the conductivity data acquired by the conductivity data acquisition unit 131 is within a predetermined range by referring to the reference conductivity storage unit 133 and the reference data stored in the reference conductivity storage unit 133.
  • a syringe pump control unit 134 for controlling the syringe pump.
  • the automatic analyzer 10 that performs electrolyte analysis is described, but the analysis items are not limited to electrolyte analysis. It can be applied as long as it has a channel through which a plurality of types of liquids pass.
  • FIG. 3 is an example of a flow chart of electrolyte analysis. Note that the electrolyte analysis process shown in FIG. 3 is mainly controlled by the controller 113 .
  • the controller 113 first operates the syringe pump 109 to aspirate the reagent (step S101). As a result, the channel in the electrolyte analysis section 108 is filled with the reagent.
  • the controller 113 measures the potential of the liquid (reagent) in the electrolyte analysis unit 108 by controlling the electrolyte analysis unit 108 (step S102).
  • the measured data is stored in the storage section of the controller 113 via the data acquisition section.
  • the controller 113 operates the sample dispensing probe 107 to dispense the sample from the sample container 101 to the dilution tank 103 (step S103).
  • the controller 113 operates the dilution pump 110 to discharge the diluent into the dilution tank 103 (step S104).
  • the sample is diluted so that the sample amount and the diluent amount become the set ratio.
  • the controller 113 operates the syringe pump 109 to aspirate the diluted sample in the dilution tank 103 (step S105).
  • the channel in the electrolyte analysis section 108 is filled with the diluted sample.
  • the controller 113 measures the potential of the liquid (diluted sample) in the electrolyte analysis unit 108 by controlling the electrolyte analysis unit 108 (step S106).
  • the measured data is stored in the storage section of the controller 113 via the data acquisition section.
  • the controller 113 uses the potential of the reagent and the potential of the diluted sample to calculate the electrolyte concentration of the analyte contained in the sample (step S107), stores it in the storage unit, and displays it on the computer 112. section (step S108).
  • step S107 when a plurality of samples are continuously subjected to electrolyte analysis, after step S107 is completed, the process returns to step S101, and steps S102 to S108 are repeated thereafter.
  • FIG. 4 is a time chart showing the operation sequence of each part in the automatic analyzer 10 according to the first embodiment.
  • the reagent electromagnetic valve 116 and the suction-side electromagnetic valve 118 open the flow path including the electrolyte analysis unit 108 and the conductivity measurement unit 111 (S11), and the syringe pump 109 starts the suction operation. After a certain amount of the reagent is supplied to the channel, the syringe pump 109 stops the suction operation, and the conductivity measuring section 111 measures the conductivity of the liquid in the conductivity measuring section 111 (S12). The measured conductivity is stored in the storage section of the controller 113 and output to the display section of the computer 112 . When the conductivity measuring unit 111 measures a predetermined conductivity, the flow path is replaced with the reagent, so the flow path is blocked by the reagent electromagnetic valve 116 and the suction side electromagnetic valve 118 (S13).
  • each electromagnetic valve shuts off the flow path after the conductivity is measured in S12 and the determination unit 132 determines that the replacement of the liquid (replacement with the reagent) is completed. If the conductivity is to be measured after each solenoid valve has blocked the flow path, each solenoid valve must be opened again if the conductivity has not reached a predetermined level. The opening/closing operation of the solenoid valve causes the liquid in the flow path to sway, and as a result, the measurement and analysis in the conductivity measurement unit 111 and the electrolyte analysis unit 108 are affected.
  • the flow path on the downstream side of the syringe pump 109 is opened by the drain-side electromagnetic valve 119 (S14), and the syringe pump 109 performs the return-to-origin operation (S15), whereby the residual liquid is discharged to the drain section 114. be done.
  • the flow path is blocked by the discharge side electromagnetic valve 119 (S16).
  • the electrolyte analysis unit 108 measures the potential of the liquid (reagent) (S17).
  • the sample is dispensed from the predetermined sample container 101 to the dilution tank 103 by the sample dispensing probe 107 according to the analysis item requested by the computer 112. be done. Further, the dilution pump 110 sends a predetermined amount of diluent to the dilution tank 103 to dilute the sample (S18). Thereafter, the dilution solenoid valve 117 and the suction side solenoid valve 118 open the flow path including the electrolyte analysis section 108 and the conductivity measurement section 111 (S19), and the syringe pump 109 starts suction operation.
  • the conductivity measuring section 111 measures the conductivity of the liquid in the conductivity measuring section 111 (S20).
  • the measured conductivity is stored in the storage section of the controller 113 and output to the display section of the computer 112 .
  • the conductivity measuring unit 111 measures a predetermined conductivity, the channel is replaced with the diluted sample, so the channel is blocked by the dilution solenoid valve 117 and the suction side solenoid valve 118 ( S21).
  • the flow path on the downstream side of the syringe pump 109 is opened by the drain-side solenoid valve 119 (S22), and the syringe pump 109 performs the return-to-origin operation (S23), whereby the residual liquid is discharged to the drain section 114. be done.
  • the flow path is blocked by the discharge side electromagnetic valve 119 (S24).
  • the electrolyte analysis unit 108 measures the potential of the liquid (diluted sample) (S25).
  • FIG. 5 is a time chart showing another operation sequence of each part in the automatic analyzer 10 according to the first embodiment.
  • the conductivity measurement unit 111 continuously measures the conductivity in parallel with the suction operation of the syringe pump 109 .
  • the operation sequence other than the reagent conductivity measurement operation (S26) and the diluted sample conductivity measurement operation (S27) by the conductivity measurement unit 111 is the same as in FIG.
  • FIG. 6 is a flow chart showing the processing of the syringe pump.
  • the determination unit 132 acquires the reference data of the liquid being sucked from the reference conductivity storage unit 133 (step S1). Next, in parallel with the suction operation of the syringe pump 109, the conductivity measurement operation of the reagent (S26 in FIG. 5) and the conductivity measurement operation of the diluted sample (S27 in FIG. 5) are performed by the conductivity measurement unit 111. Executed (step S2) Further, the determination unit 132 refers to the reference data in the reference conductivity storage unit 133, and determines whether the data acquired by the conductivity data acquisition unit 131 has reached a predetermined conductivity. is determined (step S3).
  • the determination unit 132 sends a signal to the syringe pump control unit 134 to stop the syringe pump 109, and proceeds to the next operation, that is, blockage of the flow path (S13 or S21 in FIG. 5) (step S4).
  • step S3 when the data acquired by the conductivity data acquisition unit 131 has not reached the predetermined conductivity, the determination unit 132 determines whether the syringe pump 109 has operated to the upper limit value.
  • the upper limit is an amount set with a certain margin with respect to the operating amount of the syringe pump 109 at which the liquid in the flow path is expected to be completely replaced and the predetermined conductivity is reached. Further, as a specific amount of the upper limit, there are the number of pulses of the motor constituting the syringe pump 109, the drive time, and the like.
  • step S5 when the operation of the syringe pump 109 reaches the upper limit, the syringe pump control unit 134 stops the operation of the syringe pump 109 and stops the liquid supply (step S6).
  • the determination unit 132 outputs an alarm to the display unit of the computer 112 to notify that the liquid replacement operation is abnormal (step S7).
  • FIG. 7 is a schematic diagram showing the structure of the conductivity measuring part 111 and its surrounding flow path in Example 1.
  • the conductivity measuring section 111 of this embodiment is composed of a conductivity detecting section 120 .
  • the conductivity detection unit 120 includes a channel connected to the electrolyte analysis unit 108 and an electrode 121 for detecting conductivity, and is capable of measuring the conductivity of the liquid flowing through the channel.
  • FIG. 8 is a schematic diagram showing the structure of another conductivity measuring part and its peripheral flow path in Example 1.
  • the conductivity measuring section of this embodiment is composed of a solenoid valve 122 with an electrode.
  • the conductivity detection unit 120 in the flow path, so the number of parts can be reduced and the cost can be reduced.
  • the electrode-equipped solenoid valve has the electrode 121 capable of measuring the conductivity inside the solenoid valve, so that the conductivity can be measured more accurately.
  • the inside of the flow path up to the conductivity measurement unit 111, including the electrolyte analysis unit 108, can be completely replaced with the liquid to be fed using the minimum amount of liquid used.
  • the quantitative evaluation method of liquid replacement in electrolyte analysis was described, but the quantitative evaluation of liquid replacement by this method is not limited to electrolyte analysis, and multiple types of liquids with different physical quantities pass through the same flow path. If it is a flow path that does, it can be expected to reduce the amount of liquid used. That is, according to this embodiment, by measuring the physical quantity in the flow channel during the replacement operation and stopping the replacement operation when the physical quantity of the liquid after replacement reaches the range, the completion of replacement can be confirmed and the reagent consumption amount can be determined. can be reduced.
  • the measurement unit measures the conductivity of the liquid in the flow channel, and when the conductivity reaches a predetermined value, the determination unit determines whether the flow channel contains detergent or water. It is determined that it has been replaced. As a result, a constant amount of detergent or water that fills the flow path on the upstream side of the measuring section is sequentially supplied to the downstream side, making it possible to obtain cleaning liquid with a constant dilution rate.
  • the dilution of the detergent will be described, but the quantitative dilution according to this method can be applied not only to the dilution of the detergent but also to other dilutions as long as two or more liquids having different physical quantities are used.
  • FIG. 9 is an example of a schematic configuration diagram of an automatic analyzer 20 that performs detergent dilution to which Embodiment 2 is applied.
  • the automatic analyzer 20 of the present embodiment includes a sample disk 202 capable of mounting a plurality of sample containers 201 (collection tubes) holding samples, and a sample disk 202 capable of mounting a plurality of reagent containers 203 holding reagents. It includes a first reagent disk 204, a second reagent disk 205, and a reaction disk 207 having a plurality of reaction containers 206 arranged on its circumference.
  • the automatic analyzer 20 of this embodiment includes a sample dispensing probe 208 that dispenses a sample aspirated from a sample container 201 into a reaction container 206, and a reagent aspirated from the reagent container 203 in the first reagent disk 204 for reaction.
  • a channel 21 and a detergent probe 211 for sucking detergent from the detergent dilution channel 21 and discharging it into the reaction container 206 are provided.
  • the automatic analyzer 20 of this embodiment includes a stirring device 212 for stirring the liquid in the reaction container 206, a container cleaning mechanism 213 for cleaning the reaction container 206, and a light source installed near the inner periphery of the reaction disk 207. 214, a spectroscopic detector 215, a computer 216 connected to the spectroscopic detector 215, and a controller 217 that controls the overall operation of the automatic analyzer 20 and exchanges data with the outside.
  • FIG. 10 is an example of a schematic diagram of the detergent dilution channel 21 in the automatic analyzer 20 of the second embodiment.
  • the detergent dilution flow path 21 includes a detergent pump 219 that feeds detergent, a water pump 220 that feeds water, and a diluted detergent pump 221 that feeds diluted detergent. , a three-way electromagnetic valve 222 that switches the flow path to prevent backflow of the liquid, a conductivity measurement unit 223 that measures the conductivity of the liquid, a detergent dilution tank 224 that dilutes the detergent with water, a detergent probe 211, A detergent container 225 and a water container 226 are provided.
  • FIG. 11 is a flow chart showing the process from diluting the detergent with water to discharging it into the reaction container. Note that the processing shown in FIG. 11 is mainly controlled by the controller 113 .
  • the controller 113 switches the three-way electromagnetic valve 222 and uses the detergent pump 219 to feed a certain amount of detergent from the detergent container 225 (step S201).
  • the controller 113 switches the three-way solenoid valve 222 and uses the water pump 220 to feed a certain amount of water from the water container 226 (step S202).
  • a certain amount of water is added to the detergent dilution tank 224 containing a certain amount of detergent, and the detergent is diluted with water in the detergent dilution tank 224 .
  • the controller 113 sends the diluted detergent in the detergent dilution tank 224 to the detergent probe 211 using the diluted detergent pump 221, and discharges it into the reaction container 206 as a cleaning liquid (step S203).
  • steps S201 to S203 are repeated.
  • FIG. 12 is a time chart showing the operation sequence of each part in the automatic analyzer 20 according to the second embodiment.
  • the three-way electromagnetic valve 222 located upstream of the conductivity measuring section 223 is actuated to connect the detergent container 225 and the detergent dilution tank 224 (S31).
  • the conductivity measuring unit 223 starts measuring the conductivity of the liquid in the detergent dilution channel 21, and the detergent pump 219 operates until the conductivity reaches a predetermined value (detergent determination value).
  • the detergent liquid is sent (S32). While the detergent pump 219 is pumping the detergent, the conductivity measuring section 223 continuously measures the conductivity.
  • the three-way solenoid valve 222 is switched to connect the water container 226 and the detergent dilution tank 224 (S33).
  • the conductivity measurement unit 223 starts measuring the conductivity of the liquid in the detergent dilution channel 21, and the water pump 220 operates until the conductivity reaches a predetermined value (water judgment value). Water is sent (S34). While the detergent pump 219 is pumping the detergent, the conductivity measuring section 223 continuously measures the conductivity.
  • the diluted detergent is sent from the detergent dilution tank 224 to the detergent probe 211 and discharged from the detergent probe 211 to the reaction container 206 (S35).
  • the flow path between the conductivity measuring part 223 and the three-way electromagnetic valve 222 is filled with detergent. Therefore, when the water pump 220 operates, a fixed amount of detergent for the passage between the conductivity measuring section 223 and the three-way electromagnetic valve 222 is supplied to the detergent dilution tank 224 . Thereafter, the flow path between the conductivity measuring unit 223 and the three-way solenoid valve 222 is filled with water, and when the detergent pump 219 operates in this state, a certain amount of water is supplied to the detergent dilution tank 224.
  • the dilution rate of the detergent can be kept constant, and as a result, there is an advantage that the excessive supply of detergent can be avoided. Furthermore, by providing a plurality of conductivity measuring units 223 in the flow path, the amount of liquid to be fed can be changed, and thus the dilution ratio can be adjusted.
  • the conductivity of the detergent itself or the water itself before being diluted (mixed) is measured, so if there is an abnormality (such as deterioration in quality) inherent in either liquid itself, can also be discriminated.
  • the present invention is not limited to the above-described embodiments, and includes various modifications.
  • the conductivity sensor was used as an example of the measurement unit, but a sensor that can quantitatively measure physical quantities other than conductivity, such as heat transfer coefficient and density, is used as the measurement unit.
  • a sensor that can quantitatively measure physical quantities other than conductivity, such as heat transfer coefficient and density is used as the measurement unit.
  • Sample Dispensing probe 108 Electrolyte analysis unit 109 Syringe pump 110 Dilution pump 111 Conductivity measurement unit 112 Computer 113 Controller 114 Drainage unit 115 Cleaning electromagnetic valve 116 Reagent Solenoid valve 117 Dilution solenoid valve 118 Suction side solenoid valve 119 Drainage side solenoid valve 120 Conductivity detector 121 Electrode 122 Solenoid valve with electrode 131 Conductivity data acquisition unit DESCRIPTION OF SYMBOLS 132... Determination part 133... Reference conductivity storage part 134... Syringe pump control part 20... Automatic analyzer 21... Detergent dilution flow path 201... Sample container 202... Sample disk 203... Reagent container 204...

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Abstract

Le but de la présente invention est de fournir un dispositif d'analyse automatisé au moyen duquel il est possible de réduire le coût de fonctionnement par diminution de la quantité d'utilisation de réactifs et de détergents et par suppression de la fréquence d'échange de récipients de réactif et de récipients de détergent. À cet effet, la solution selon la présente invention concerne un dispositif d'analyse automatisé qui comprend : un trajet d'écoulement par lequel s'écoule une pluralité de types de fluides ; une pompe permettant de fournir les fluides au trajet d'écoulement ; une unité de mesure permettant de mesurer la quantité physique relative à chacun des fluides fournis par le trajet d'écoulement ; et une unité de détermination permettant de déterminer que, sur la base de la quantité physique mesurée par l'unité de mesure, un fluide à l'intérieur du trajet d'écoulement sur le côté amont de l'unité de mesure a été remplacé par un fluide particulier.
PCT/JP2022/004287 2021-03-15 2022-02-03 Dispositif d'analyse automatisé et procédé de confirmation de trajet d'écoulement WO2022196157A1 (fr)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007506080A (ja) * 2003-09-15 2007-03-15 ディアグノスイス ソシエテ アノニム 流れ監視マイクロフルイディックデバイス
JP2017015418A (ja) * 2015-06-29 2017-01-19 東ソー株式会社 試薬調製装置および検体分析装置
CN208193738U (zh) * 2018-01-31 2018-12-07 国家海洋局北海环境监测中心 一种用于海水中油类分析的全自动液液萃取仪

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007506080A (ja) * 2003-09-15 2007-03-15 ディアグノスイス ソシエテ アノニム 流れ監視マイクロフルイディックデバイス
JP2017015418A (ja) * 2015-06-29 2017-01-19 東ソー株式会社 試薬調製装置および検体分析装置
CN208193738U (zh) * 2018-01-31 2018-12-07 国家海洋局北海环境监测中心 一种用于海水中油类分析的全自动液液萃取仪

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