WO2022178983A1 - Préparation externe de médicament naturel, procédé de préparation et application de celui-ci - Google Patents

Préparation externe de médicament naturel, procédé de préparation et application de celui-ci Download PDF

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Publication number
WO2022178983A1
WO2022178983A1 PCT/CN2021/093281 CN2021093281W WO2022178983A1 WO 2022178983 A1 WO2022178983 A1 WO 2022178983A1 CN 2021093281 W CN2021093281 W CN 2021093281W WO 2022178983 A1 WO2022178983 A1 WO 2022178983A1
Authority
WO
WIPO (PCT)
Prior art keywords
external preparation
preparation
acid
natural medicine
medicine according
Prior art date
Application number
PCT/CN2021/093281
Other languages
English (en)
Chinese (zh)
Inventor
王邵辉
付艳波
Original Assignee
杭州泽宇生物技术有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 杭州泽宇生物技术有限公司 filed Critical 杭州泽宇生物技术有限公司
Publication of WO2022178983A1 publication Critical patent/WO2022178983A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne une préparation externe de leukaménine F, comprenant 0,001 % en poids à 5 % en poids de leukaménine F, 0,01 % en poids à 30 % en poids d'un agent de solubilisation, et 1 % en poids à 99 % en poids d'une matrice de préparation externe. La forme pharmaceutique de la préparation externe est une crème, un gel ou un spray. L'invention concerne également un procédé de préparation de crème à base de leukaménine F. L'invention concerne également une application d'une préparation externe de leukaménine F dans la préparation de médicaments pour le traitement du psoriasis, du lupus érythémateux, de l'eczéma et de la dermatite atopique. La préparation externe de leukaménine F permet de surmonter les inconvénients de la leukaménine F, à savoir une mauvaise solubilité dans l'eau, une faible biodisponibilité, une élimination in vivo rapide, une demi-vie courte, une dose requise importante et une préparation médicamenteuse difficile.
PCT/CN2021/093281 2021-02-25 2021-05-12 Préparation externe de médicament naturel, procédé de préparation et application de celui-ci WO2022178983A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202110213755.X 2021-02-25
CN202110213755.XA CN113018250A (zh) 2021-02-25 2021-02-25 一种天然药物的外用制剂、制备方法及其应用

Publications (1)

Publication Number Publication Date
WO2022178983A1 true WO2022178983A1 (fr) 2022-09-01

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Application Number Title Priority Date Filing Date
PCT/CN2021/093281 WO2022178983A1 (fr) 2021-02-25 2021-05-12 Préparation externe de médicament naturel, procédé de préparation et application de celui-ci

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Country Link
CN (1) CN113018250A (fr)
WO (1) WO2022178983A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113786473A (zh) * 2021-10-20 2021-12-14 海南三元星生物科技股份有限公司 一种海洋生物抗菌肽药物及其制备方法
CN116966179A (zh) * 2022-04-22 2023-10-31 苏州沪云新药研发股份有限公司 二萜化合物衍生物或其盐在制备防治特应性皮炎的药物中的应用
CN116688017A (zh) * 2023-06-29 2023-09-05 浙江工业大学 一种具有银屑病治疗功效的蓝萼香茶菜复方软膏及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1600301A (zh) * 2003-09-25 2005-03-30 李跃亨 治疗皮癣的外用药剂
CN102258568A (zh) * 2010-05-27 2011-11-30 迪特克(济源)绿色生物科技有限公司 一种冬凌草外用抗菌霜剂的制备方法
CN104887652A (zh) * 2015-05-13 2015-09-09 苏州沪云肿瘤研究中心股份有限公司 蓝萼甲素衍生物及其药学上可接受的盐的剂型
CN110248656A (zh) * 2017-02-23 2019-09-17 苏州沪云新药研发股份有限公司 一种蓝萼甲素衍生物及其药学上可接受的盐或药物组合物及在制备治疗银屑病药物中的用途

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120070518A1 (en) * 2004-01-12 2012-03-22 Natrogen Therapeutics International, Inc. Methods and compositions for treating psoriasis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1600301A (zh) * 2003-09-25 2005-03-30 李跃亨 治疗皮癣的外用药剂
CN102258568A (zh) * 2010-05-27 2011-11-30 迪特克(济源)绿色生物科技有限公司 一种冬凌草外用抗菌霜剂的制备方法
CN104887652A (zh) * 2015-05-13 2015-09-09 苏州沪云肿瘤研究中心股份有限公司 蓝萼甲素衍生物及其药学上可接受的盐的剂型
CN110248656A (zh) * 2017-02-23 2019-09-17 苏州沪云新药研发股份有限公司 一种蓝萼甲素衍生物及其药学上可接受的盐或药物组合物及在制备治疗银屑病药物中的用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Pharmaceutics, 2nd Edition", 31 January 2018, JIANGSU PHOENIX SCIENCE AND TECHNOLOGY PRESS, CN, ISBN: 978-7-5537-8656-8, article YAN, HAIYAN: "Method of Improving Solubility of Drugs", pages: 30, XP009539626 *

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Publication number Publication date
CN113018250A (zh) 2021-06-25

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