WO2022138249A1 - 自動分析装置および分析方法 - Google Patents

自動分析装置および分析方法 Download PDF

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Publication number
WO2022138249A1
WO2022138249A1 PCT/JP2021/045644 JP2021045644W WO2022138249A1 WO 2022138249 A1 WO2022138249 A1 WO 2022138249A1 JP 2021045644 W JP2021045644 W JP 2021045644W WO 2022138249 A1 WO2022138249 A1 WO 2022138249A1
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WIPO (PCT)
Prior art keywords
reagent
measurement
photometer
absorptiometer
analysis
Prior art date
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PCT/JP2021/045644
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English (en)
French (fr)
Japanese (ja)
Inventor
朋浩 松永
千枝 藪谷
博 大賀
興子 山本
昌彦 飯島
Original Assignee
株式会社日立ハイテク
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Application filed by 株式会社日立ハイテク filed Critical 株式会社日立ハイテク
Priority to JP2022572148A priority Critical patent/JP7420976B2/ja
Priority to CN202180078655.9A priority patent/CN116685843A/zh
Publication of WO2022138249A1 publication Critical patent/WO2022138249A1/ja

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/82—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

Definitions

  • the present invention relates to an automatic analyzer and an analysis method for clinical examination.
  • Document 1 includes, for example, two types of photometric meters having different quantification ranges and an analysis control unit that controls analysis including measurement using two types of photometric meters for a target sample, and the analysis control unit has two types. If two types of data alarms are added to the two types of measurement results using the photometric meter, depending on the abnormality at the time of measurement, etc., the data is output in correspondence with the combination of the two types of data alarms. It is described that the measurement result and the data alarm are selected and output to the user as the analysis result.
  • the automatic analyzer for clinical examination detects the concentration and amount of the target component substance contained in a biological sample (hereinafter referred to as a sample) such as blood and urine based on optical measurement.
  • a biological sample hereinafter referred to as blood and urine
  • an absorptiometry method for measuring the amount of transmitted light of a sample is often used.
  • the absorptiometry method light from a light source is applied to a sample or a reaction solution (a mixed solution of a sample and a reagent), and the amount of transmitted light having one or more wavelengths obtained as a result is measured to calculate the absorbance. Then, in the absorptiometry, the amount of the target component substance is determined from the relationship between the absorbance and the concentration according to Lambert-Beer's law.
  • an automatic analyzer for clinical examination for example, a device that realizes high sensitivity of immunoassay by using a light scattering detection method that utilizes a change in the amount of scattered light that easily captures a larger change in the amount of light is known. ing.
  • the agglomerates generated by the antigen-antibody reaction are irradiated with light, and at least one of the light amount and the light intensity of the scattered light scattered by the agglomerates is measured. After that, the component amount of the target component substance is obtained from the relationship between the light amount or the light intensity and the concentration.
  • Patent Document 1 discloses a method of realizing a suitable output from measurement results and alarm contents when measured using two or more types of photometers, and a method of realizing suitable automatic re-examination control.
  • a reagent used for measurement with an absorptiometer and a reagent used for measurement with a scattering photometer. It had to be installed. This is because the reagent concentration suitable for each measurement is different, and there is a problem that a suitable quantification range cannot be obtained when the measurement is performed using the same reagent for the absorptiometer and the scattering photometer. ..
  • the reagent concentration is suitable for measurement with a scattering photometer, but low for measurement with an absorptiometer. There is no problem in measuring the low concentration region using a scattering photometer, but in the measurement of the high concentration region using an absorptiometer, the upper limit of quantification becomes small due to the low concentration of the reagent, and a sufficient quantification range can be obtained. May not be.
  • the reagent concentration is suitable for measurement with an absorptiometer, considering the case where it is dark for measurement with a scattering photometer, the measurement sensitivity of the scattering photometer decreases, and the low concentration region should be quantified. May not be possible.
  • the present invention provides an automatic analyzer and an analysis method capable of solving the above-mentioned problems of the prior art and obtaining a suitable quantification range with an absorptiometer and a scattering photometer without squeezing the volume of a reagent disk. ..
  • the present invention includes a plurality of means for solving the above problems, and to give an example thereof, a reaction vessel containing a reaction solution produced by mixing a sample and a reagent, and the reagent in the reaction vessel.
  • a reagent dispensing mechanism that dispenses reagents, an absorptiometer that measures the light transmitted through the reaction solution, a scattered photometer that measures the light scattered in the reaction solution, and controls that control the operation of each device.
  • the control device comprises the device and controls the operation of the reagent dispensing mechanism so that the analysis by the absorptiometer and the analysis by the scattering photometer are performed with different concentrations of the same type of reagent. It is a feature.
  • FIG. 3 is a functional block diagram showing a configuration of a computer and a control unit that control the operation of the automated analyzer according to the first embodiment. It is a block diagram of the analysis parameter input screen in the automatic analyzer of Example 1.
  • FIG. It is a correspondence table which showed the correspondence of the initial measurement condition, an alarm content, and a re-examination condition in the automatic analyzer of Example 1.
  • FIG. It is a flowchart which shows the operation of the automatic analyzer in Example 1.
  • FIG. It is a flowchart which shows the operation of the automatic analyzer in Example 2 of this invention.
  • It is a flowchart which shows the operation of the automatic analyzer in Example 3 of this invention.
  • Example 1 of the automatic analyzer and the analysis method of the present invention will be described with reference to FIGS. 1 to 5.
  • FIG. 1 is a diagram showing an overall schematic configuration of the automated analyzer 1 of the first embodiment.
  • the automatic analyzer 1 shown in FIG. 1 includes a sample disk 4, a reaction disk 10, a reagent disk 7, a sample dispensing mechanism 11, a reagent dispensing mechanism 12, a control unit 17, a measuring unit 18, a computer 20, and the like.
  • the reaction disk 10 is installed between the sample disk 4 and the reagent disk 7.
  • reaction containers 9 which are containers for accommodating the reaction liquid 8 produced by mixing the sample 2 and the reagent 5 are arranged side by side so as to be separated from each other along the circumferential direction of the reaction disk 10. It is held in a state of being.
  • the reaction vessel 9 is made of a translucent material for measurement by the absorptiometer 14 and the scattered photometer 15.
  • reaction disk 10 a plurality of reaction vessels 9 are moved along the circumferential direction by rotating according to the control of the control unit 17.
  • the reaction disk 10 arranges one of the plurality of reaction containers 9 at a predetermined position provided along the circumferential direction by rotating the disk.
  • the predetermined position is, for example, a sample ejection position by the sample dispensing mechanism 11, a reagent ejection position by the reagent dispensing mechanism 12, or the like.
  • the reaction disk 10 is provided with a constant temperature bath 19, and each of the plurality of reaction vessels 9 arranged on the reaction disk 10 is constantly immersed in the constant temperature bath water (also referred to as a constant temperature fluid) in the constant temperature bath 19. ing.
  • the reaction solution 8 in the reaction vessel 9 is maintained at a constant reaction temperature (for example, about 37 ° C.).
  • the temperature and flow rate of the constant temperature bath water in the constant temperature bath 19 are controlled by the control unit 17, and the amount of heat supplied to the reaction vessel 9 is controlled.
  • the stirring unit 13, the absorptiometer 14, and the scattered photometer 15 are located on and near the circumference of the reaction disk 10 in a positional relationship in which the positions are different from each other.
  • the cleaning tank 16a, the cleaning unit 16b, and the like are arranged.
  • sample cup 3 is a sample container that houses the sample 2.
  • Each sample cup 3 is arranged and held side by side on the sample disk 4 so as to be separated from each other along the circumferential direction.
  • the reagent disk 7 is installed next to the reaction disk 10.
  • a plurality of reagent bottles 6 are installed and held on the reagent disk 7.
  • the reagent bottle 6 is a reagent container that houses the reagent 5.
  • the reagent bottle 6 contains a reagent 5 of a type corresponding to the target component substance of the inspection item in the automatic analyzer 1. Each type of reagent 5 is contained in a separate reagent bottle 6.
  • the sample dispensing mechanism 11 is installed between the sample disk 4 and the reaction disk 10, and includes a movable arm and a dispensing nozzle including a pipette nozzle attached to the movable arm.
  • the sample dispensing mechanism 11 performs a sample dispensing operation, which is an operation of sucking the sample 2 from the sample cup 3 at the sample suction position of the sample disk 4 and discharging the sample 2 to the reaction container 9 at the sample discharge position of the reaction disk 10.
  • a sample dispensing operation which is an operation of sucking the sample 2 from the sample cup 3 at the sample suction position of the sample disk 4 and discharging the sample 2 to the reaction container 9 at the sample discharge position of the reaction disk 10.
  • the dispensing nozzle is moved to the sample suction position on the sample disk 4, and a predetermined amount of sample 2 is sucked into the dispensing nozzle from the sample cup 3 arranged at the sample suction position and stored. do.
  • the sample dispensing mechanism 11 moves the dispensing nozzle to the sample ejection position on the reaction disk 10, and ejects the sample 2 in the dispensing nozzle into the reaction vessel 9 arranged at the sample ejection position.
  • the reagent dispensing mechanism 12 is installed between the reagent disk 7 and the reaction disk 10, and is provided with a movable arm and a dispensing nozzle as in the sample dispensing mechanism 11.
  • the reagent dispensing mechanism 12 performs a reagent dispensing operation, which is an operation of sucking the reagent 5 from the reagent bottle 6 at the reagent suction position of the reagent disk 7 and discharging the reagent 5 to the reaction vessel 9 at the reagent discharge position of the reaction disk 10.
  • the reagent 5 to be dispensed is a reagent used for quantification of a target component substance, which is an analysis item (also referred to as an inspection item or the like) set corresponding to the target sample 2.
  • the reagent dispensing mechanism 12 moves the dispensing nozzle to the reagent suction position on the reagent disk 7 during the reagent dispensing operation, and a predetermined amount of reagent is charged into the dispensing nozzle from the reagent bottle 6 arranged at the reagent suction position. 5 is inhaled and contained. After that, the reagent dispensing mechanism 12 moves the dispensing nozzle to the reagent discharging position on the reaction disk 10, and discharges the reagent 5 in the dispensing nozzle into the reaction vessel 9 arranged at the reagent discharging position. The sample 2 and the reagent 5 are mixed with each other to prepare a reaction solution 8.
  • the sample dispensing mechanism 11 and the reagent dispensing mechanism 12 are each provided with a washing tank 16a in preparation for dispensing different types of sample 2 or reagent 5.
  • the cleaning tank 16a is a mechanism for cleaning the dispensing nozzle.
  • Each dispensing mechanism cleans each dispensing nozzle in the cleaning tank 16a before and after the dispensing operation. This prevents contamination between the samples 2 or the reagents 5.
  • each dispensing mechanism is equipped with a sensor for detecting the liquid level of the sample 2 or the reagent 5. This makes it possible to monitor and detect measurement abnormalities due to a shortage of the sample 2 or the reagent 5.
  • the sample dispensing mechanism 11 is equipped with a pressure sensor that detects clogging of the dispensing nozzle.
  • a pressure sensor that detects clogging of the dispensing nozzle.
  • the control unit 17 can monitor and detect various abnormalities during measurement through a mechanism including those sensors.
  • sample dispensing mechanism 11 and the reagent dispensing mechanism 12 fill the dispensing nozzle with pure water (hereinafter referred to as system water), and inhale the sample 2 and the reagent 5 by driving the system water. ⁇ Discharging.
  • the sample dispensing mechanism 11 and the reagent dispensing mechanism 12 can dilute the sample or reagent to a specific concentration by simultaneously discharging the system water as diluting water and the sample 2 or reagent 5 into the reaction vessel 9. be.
  • the reaction vessel 9 into which the sample 2 has been dispensed by the sample dispensing mechanism 11 is moved to the reagent discharge position by the rotation of the reaction disk 10.
  • the reagent dispensing mechanism 12 moves the dispensing nozzle to the reagent discharging position and discharges the reagent, whereby the sample and the reagent are mixed in the reaction vessel 9.
  • the stirring unit 13 is a portion for stirring a mixed solution of the sample 2 and the reagent 5 in the reaction vessel 9 arranged at a stirring position which is a predetermined position on the reaction disk 10, and is, for example, a stirrer provided with a stirring blade. Alternatively, it is equipped with a stirring mechanism using ultrasonic waves. As a result, the mixed solution in the reaction vessel 9 is uniformly stirred and the reaction is promoted to become the reaction solution 8.
  • the automated analyzer 1 of this embodiment has one absorptiometer 14 as a first-class photometer and one scattered photometer 15 as a second-class photometer.
  • Each photometer of the absorptiometer 14 and the scattered photometer 15 has a light source and a light receiving unit as a basic structure.
  • the light source of each photometer is arranged, for example, on the inner peripheral side of the reaction disk 10, and the light receiving portion of each photometer is arranged on the outer peripheral side of the reaction disk 10.
  • Each photometer is connected to the measuring unit 18.
  • the absorptiometer 14 measures the reaction solution 8 of the reaction vessel 9 arranged at the measurement position (particularly the first measurement position) which is a predetermined position on the reaction disk 10.
  • the scattering photometer 15 measures the reaction solution 8 of the reaction vessel 9 arranged at the measurement position (particularly the second measurement position) which is a predetermined position on the reaction disk 10.
  • the absorptiometer 14 irradiates the reaction solution 8 of the reaction vessel 9 at the first measurement position with light from the light source. At that time, the absorptiometer 14 detects the light transmitted through the reaction solution 8 by the light receiving unit, and describes at least one of the light amount or the light intensity of the transmitted light having a single wavelength or a plurality of wavelengths (light amount / light intensity). There is) to measure.
  • the scattered photometer 15 irradiates the reaction liquid 8 of the reaction vessel 9 at the second measurement position with light from the light source. At that time, the scattered photometer 15 detects the scattered light scattered in the reaction liquid 8 by the light receiving unit, and measures at least one of the light amount or the light intensity of the scattered light (light amount / light intensity).
  • the cleaning unit 16b cleans the reaction vessel 9 arranged at the cleaning position on the reaction disk 10.
  • the washing unit 16b discharges the remaining reaction liquid 8 from the reaction vessel 9 for which the measurement and analysis have been completed, and cleans the reaction vessel 9.
  • the washed reaction vessel 9 can be reused. That is, the next sample 2 is dispensed from the sample dispensing mechanism 11 again, and the next reagent 5 is dispensed from the reagent dispensing mechanism 12 into the reaction vessel 9.
  • the concentration calculated from the measured value of the absorptiometer 14 is used, and when the target component of the sample 2 or the sample 2 is a low concentration.
  • the computer 20 includes a data storage unit 21, an analysis unit 22, an input unit 31, an output unit 32, and the like.
  • the computer 20 is composed of, for example, a PC, but is not limited to this, and may be composed of a circuit board such as an LSI board or a combination thereof.
  • FIG. 2 is a functional block diagram of the computer 20 and the control unit 17 that control the operation of the automatic analyzer 1 of this embodiment.
  • the computer 20 has a data storage unit 21 for storing measurement request information, analysis parameters, and measurement results, and an analysis unit 22 for analyzing data such as absorbance and scattered light intensity measured by the measurement unit 18. And the automatic re-examination determination unit 23.
  • the automatic analyzer 1 of this embodiment has an automatic re-examination function, and the automatic re-examination determination unit 23 determines the necessity of re-examination from the analysis result of the analysis unit 22, and if re-examination is necessary, the re-examination request information. Is stored in the data storage unit 21.
  • the computer 20 is connected to a measuring unit 18 that measures the sample 2 by the absorptiometer 14 and the scattered photometer 15 and a control unit 17 that controls various mechanisms, and follows the measurement request information input from the input unit 31. An analysis operation is performed, and the measured result is output from the output unit 32.
  • the computer 20 and the control unit 17 control the operation of the reagent dispensing mechanism 12 so that the analysis by the absorptiometer 14 and the analysis by the scattering photometer 15 are performed by the same type of reagent at different concentrations. ..
  • the automatic re-examination determination unit 23 of the computer 20 performs measurement with one of the absorptiometer 14 and the scattered photometer 15, and re-examines with the other photometer based on the measurement result. It is configured so that it can be selected whether or not it is. At this time, the result of the measurement by one photometer is compared with the preset threshold value, and it is determined whether or not to perform the re-examination by the other photometer based on the comparison result.
  • the measurement with the absorptiometer 14 is performed first, but in this case, the computer 20 and the control unit 17 divide the stock solution of the reagent into the reaction vessel 9 by the reagent dispensing mechanism 12. Note and measure, and based on the measurement result of the absorptiometer 14, determine whether or not to carry out the measurement with the scattered photometer 15, and when carrying out the measurement with the scattered photometer 15, dilute the stock solution of the reagent. The operation of the reagent dispensing mechanism 12 is controlled so that the diluted reagent is dispensed and measured.
  • a known method can be used as the method for preparing the diluting reagent at this time.
  • FIG. 3 is an example of a configuration diagram of an operation unit for setting analysis parameters in the first embodiment.
  • the operation unit for setting analysis parameters is configured as an application setting screen 71 as a GUI as shown in FIG.
  • the application setting screen 71 is displayed on a display device such as a display included in the output unit 32 by a predetermined operation of an operation device such as a keyboard and a mouse included in the input unit 31.
  • the analysis parameters are configured to input the settings via the input unit 31 on the application setting screen 71.
  • the application setting screen 71 has an application setting item selection field 72 and a parameter setting field 73 for each selected item.
  • "analysis” is selected in the item selection field 72, and the state in which the parameter setting field 73 for setting the analysis parameter is displayed is shown.
  • the photometer common setting field 75 for setting and inputting the analysis parameters common to the absorptiometer 14 and the scattering photometer 15 and the analysis parameters only for the absorptiometer 14 are set and input.
  • the screen configuration is divided into a setting field 76 dedicated to the absorptiometer and a setting field 77 dedicated to the scattering photometer for setting and inputting analysis parameters only for the scattering photometer 15.
  • CRP C-reactive protein (C-reactive protein)
  • C-reactive protein C-reactive protein
  • the photometric meter dedicated setting column 76 as a type of "analysis method", a method of obtaining the concentration of the target component from two measured values, that is, the measured value before the reaction or immediately after the reaction starts and the measured value at the end of the reaction. It is exemplified that the "2-point end” is set to "800/450 [nm]" as the main / sub-wavelength of the two-wavelength metering as the “measurement wavelength”. Further, "19” and “30” were selected or set as “photometric points", and "5 to 40" of the component amount (measured value of the concentration of the target component) was selected or set as the "quantitative range" by the absorptiometer 14. The state is illustrated.
  • FIG. 4 is an example of a correspondence table in which the combination of the initial measurement condition and the alarm content and the correspondence of the re-examination condition are defined in the inspection flow of this embodiment.
  • the automatic re-examination determination unit 23 selects conditions such as a photometer, a reagent concentration, and a sample amount to be used at the time of re-examination, and requests re-examination.
  • the control unit 17 and the measurement unit 18 control the operation of each unit including the reagent dispensing mechanism 12 so as to execute the re-examination operation.
  • the result of the initial measurement by the absorbance photometer 14 is lower than the lower limit of the "quantification range" set in the absorbance meter dedicated setting column 76 on the analysis parameter of FIG. This is an alarm that occurs when you are. In this case, a re-examination with a scattering photometer 15 capable of measuring a lower concentration is performed.
  • the prozone alarm is a data alarm that occurs when the amount of antigen or antibody in sample 2 in immunoassay is excessive.
  • Examples of the determination method for this include a known reaction rate ratio method, an antigen / antibody re-addition method, and the like.
  • the reaction rate ratio method from the reaction process of the target component substance of the inspection item, the amount of change in absorbance (or the amount of change in scattered light intensity) per unit time at the beginning of the reaction and the amount of change in absorbance (or the change in scattered light intensity) at the end of the reaction. Amount) is calculated and compared with a preset threshold.
  • an antigen or antibody is additionally added after the reaction is completed, and the amount of change in absorbance or the amount of change in scattered light intensity per unit time immediately after the addition is calculated and compared with a preset threshold value. do.
  • FIG. 5 shows, in the first embodiment of the present invention, in addition to the flowchart for determining whether or not to perform the measurement with the absorptiometer 14 first and switch to the scattered photometer 15 to perform the re-examination, the scattered photometer 15 It is a flowchart which added the process of determining whether or not to calculate the dilution ratio used at the time of re-examination in.
  • the measurement request information and the analysis parameter information input from the input unit 31 are referred to, and when the analysis request method is "absorption analysis", the control unit 17 and the measurement unit 18 indicate a command signal from the computer 20. Based on the above, the measurement with the absorptiometer 14 with the undiluted solution reagent is first carried out (step S101).
  • step S101 the control unit 17 dispenses the reagent 5 of the undiluted solution into the reaction vessel 9 by the reagent dispensing mechanism 12, and the measuring unit 18 stores the measurement data by the absorptiometer 14 in the data storage unit 21.
  • the analysis unit 22 analyzes the measurement data, and the automatic retest determination unit 23 compares the measurement result with the quantification range of the absorption analysis on the analysis parameters, and the sample concentration is lower than the lower limit of the quantification range of absorption. Whether or not it is determined (step S102).
  • step S107 the process proceeds to step S107, the result is output and displayed on the output unit 32 (step S107), and the process is completed.
  • step S103 for re-examination by the scattering photometer 15.
  • step S102 If it is determined in step S102 that the sample concentration is higher than the upper limit of the absorption quantification range, it is considered that the sample concentration does not fall within the quantification range even if the photometer is changed or the reagent is diluted. In such a case, after step S102 and before step S107, a step of performing a retest under the condition that only the sample concentration is reduced without changing the photometer and the reagent concentration is executed.
  • the automatic re-examination determination unit 23 determines whether or not it is necessary to calculate the dilution concentration (step S103). For example, in this step S103, (i) dilute to a predetermined reagent concentration from the analysis parameter information, (ii) the reagent dilution ratio is not determined, and the reagent is diluted to the reagent concentration calculated from the reaction process of the initial measurement. It is determined which of the two methods,, and, is selected.
  • step S105 it is not necessary to calculate the reagent dilution ratio, so the process proceeds to step S105, whereas in the case of (ii), the process proceeds to step S104, and the analysis unit 22 reacts during the initial measurement.
  • the reagent dilution ratio suitable for the scattering analysis is calculated from (step S104), and the process proceeds to step S105.
  • control unit 17 and the measurement unit 18 perform a re-examination with the scattering photometer 15 (step S105).
  • the control unit 17 dispenses the reagent 5 diluted with system water by the reagent dispensing mechanism 12 into the reaction vessel 9, and the measuring unit 18 stores the measurement result by the scattering photometer 15 in the data storage unit 21.
  • the output unit 32 displays the measurement result by the scattering photometer 15 (step S106), and completes the process.
  • the computer 20 and the control unit 17 perform the analysis by the absorptiometer 14 and the analysis by the scattering photometer 15 with the same kind of reagents at different concentrations.
  • the operation of the reagent dispensing mechanism 12 is controlled.
  • the computer 20 can select whether or not to perform the measurement by one of the absorptiometer 14 and the scattered photometer 15 and re-examine by the other photometer based on the measurement result. Therefore, the measurement is performed by the other photometer only when re-examination is required, and it is possible to suppress the consumption of the sample or the reagent more than necessary.
  • the computer 20 is higher by comparing the measurement result by one photometer with the preset threshold value and determining whether to perform the re-examination by the other photometer based on the comparison result. It is possible to determine the necessity of re-inspection with accuracy.
  • the computer 20 and the control unit 17 dispense the undiluted solution of the reagent into the reaction vessel 9 by the reagent dispensing mechanism 12 and measure the absorptiometer 14. Based on the measurement result of the above, it is determined whether or not to carry out the measurement by the scattering photometric meter 15, and when the measurement is carried out by the scattering photometric meter 15, the diluted reagent obtained by diluting the stock solution of the reagent is dispensed and measured.
  • the reagent dispensing mechanism 12 By controlling the operation of the reagent dispensing mechanism 12 as described above, it is possible to obtain the effect that scattered light analysis can be performed even with a reagent suitable for measuring the absorbance.
  • Example 2 The automatic analyzer and the analysis method of the second embodiment of the present invention will be described with reference to FIG.
  • the sample amount is determined by the presence or absence of the prozone alarm. It is a flowchart which added the process of determining whether or not to change.
  • the computer 20 and the control unit 17 of this embodiment dispense and measure the diluted reagent obtained by diluting the undiluted solution of the reagent with system water by the reagent dispensing mechanism 12. Based on the measurement result of the scattered photometric meter 15, it is determined whether or not to carry out the measurement by the absorptiometer 14, and when the measurement is carried out by the absorptiometer 14, the undiluted solution of the reagent is divided in the reaction vessel 9. The operation of the reagent dispensing mechanism 12 is controlled so as to be poured and measured.
  • Example 1 is No. 4 in FIG. Although it was the re-examination flow of No. 1, in Example 2, No. 1 in FIG. 2, No. It becomes the re-examination flow of 3.
  • Example 2 shown in FIG. 6 The treatment flow in Example 2 shown in FIG. 6 is different from the treatment flow in Example 1 shown in FIG. Since the reagent of No. 1 is used, the flow for calculating the dilution ratio is omitted. The details will be described below.
  • control unit 17 dispenses the reagent 5 diluted with system water by the reagent dispensing mechanism 12 into the reaction vessel 9, and the measuring unit 18 stores the measurement data by the scattering photometer 15 in the data storage unit 21 (step). S201). At this time, the dilution ratio of the reagent 5 diluted by the reagent dispensing mechanism 12 is the one set on the analysis parameters.
  • the analysis unit 22 analyzes the measurement data, and the automatic retest determination unit 23 compares the measurement result with the quantitative range of the absorption analysis on the analysis parameters, and the sample concentration is higher than the upper limit of the scattering quantitative range. It is determined whether it is high or not (step S202).
  • step S208 the result is displayed on the output unit 32 (step S208), and the process is terminated.
  • step S203 the process proceeds to step S203 for setting the conditions for the absorption analysis.
  • the automatic re-examination determination unit 23 determines whether or not a prozone alarm has occurred from the analysis result in step S202 (step S203). When it is determined that the prozone alarm has occurred, the process proceeds to step S204, and when it is determined that the prozone alarm has not occurred, the process proceeds to step S206.
  • control unit 17 When it is determined that the prozone alarm has occurred, the control unit 17 then reduces the sample volume by the sample dispensing mechanism 11 and dispenses it into the reaction vessel 9, and the reagent dispensing mechanism 12 dispenses the undiluted reagent. 5 is dispensed into the reaction vessel 9 (step S204).
  • the measuring unit 18 stores the measurement data by the absorptiometer 14 in the data storage unit 21, and the output unit 32 displays the measurement result of the absorptiometer 14 (step S205) to complete the process.
  • step S203 when it is determined in step S203 that the prozone alarm has not occurred, the control unit 17 then dispenses the sample into the reaction vessel 9 with the standard amount by the sample dispensing mechanism 11 and the reagent.
  • the undiluted reagent 5 is dispensed into the reaction vessel 9 by the dispensing mechanism 12 (step S206).
  • the measuring unit 18 stores the measurement data by the absorptiometer 14 in the data storage unit 21, and the output unit 32 displays the measurement result of the absorptiometer 14 (step S207) to complete the process.
  • the computer 20 and the control unit 17 diluted the stock solution of the reagent by the reagent dispensing mechanism 12 when the measurement by the scattering photometric meter 15 was performed first.
  • the diluting reagent is dispensed and measured, and based on the measurement result of the scattered photometric meter 15, it is determined whether or not the measurement by the absorptiometer 14 is carried out.
  • Example 1 the measurement with the absorptiometer 14 was performed first, and in Example 2, the measurement with the scattering photometer 15 was performed first, but these can be changed on the analysis parameters. can do. Which measurement should be performed first depends on the tendency of the sample to be measured, the characteristics of the test items / reagents, and the operation policy of the operator, and can be arbitrarily adopted.
  • the measurement that is basically emphasized should be performed first, and if the dynamic range is emphasized, the absorption analysis should be performed first, and if the sensitivity is emphasized, the scattering analysis should be performed first. For items such as D-dimer where the presence or absence of thrombus is important, the sensitivity-oriented scattering analysis is performed first.
  • FIG. 7 is a flowchart showing the operation of the automatic analyzer in the third embodiment.
  • Example 1 the measurement was performed with one of the photometers for the first time, and the re-examination was performed with a different photometer based on the result.
  • the absorptiometer 14 The same type of reagent is carried out at different reagent concentrations by both the measurement using the method and the measurement using the scattering photometer 15.
  • the computer 20 and the control unit 17 carry out measurements by both the absorptiometer 14 and the scattered photometer 15, and adopt the measurement results of either photometer based on the measurement results of both photometers. Is determined.
  • control unit 17 dispenses the sample into the two reaction vessels 9 by the sample dispensing mechanism 11, and the dilution ratio set by the reagent dispensing mechanism 12 into the two reaction vessels 9 by the undiluted reagent and the analysis parameters, respectively.
  • Dispense two types of diluting reagents The reaction vessel 9 to which the undiluted reagent is dispensed is measured by the absorptiometer 14, and the reaction vessel 9 to which the diluting reagent is dispensed is measured by the scattering photometer 15 (step S301).
  • the analysis unit 22 analyzes the measured data and then determines whether the measured sample concentration is within the quantification range of the absorptiometer 14 and within the quantification range of the scattering photometer 15. It is determined whether or not (step S302).
  • step S302 when it is determined that the measurement result is within the quantification range of the scattering photometer 15 and is in the low concentration region which is the quantification range of the absorptiometer 14, the analysis unit 22 determines that the result of the scattering photometer 15. Is output (step S303), and the process is completed.
  • step S302 when it is determined that the measurement result is in the high concentration region within the quantification range of the absorptiometer 14 and outside the quantification range of the scattered photometer 15, the analysis unit 22 uses the absorptiometer.
  • the result of 14 is output (step S305), and the process is completed.
  • step S302 when it is determined that the measurement result extends over the quantification ranges of both the absorptiometer 14 and the scattered photometer 15, the analysis unit 22 measures the measurement results of both the absorptiometer 14 and the scattered photometer 15. Is output (step S304), and the process is completed.
  • step S304 the measurement results of both the absorptiometer 14 and the scattering photometer 15 are not limited to the output, and the result of either one, which is closer to the middle of the quantification range, is output. It is possible to perform processing such as outputting the average value of the results of.
  • the computer 20 performs measurements with both the absorptiometer 14 and the scattered photometer 15, and either of them is based on the measurement results of both photometers. By determining whether to adopt the measurement result by the photometer, almost the same effect as the above-mentioned automated analyzer and analysis method of the first embodiment can be obtained.
  • FIG. 8 is a diagram showing an example of an analysis parameter setting screen of the automatic analyzer in the fourth embodiment.
  • the reagent dispensing mechanism 12 discharges the reagent stock solution in the measurement using the absorptiometer 14, and the system water in addition to the reagent in the measurement using the scattered photometer 15. It was a form in which the reagent was discharged and the reagent was diluted and the reagent was dispensed.
  • the first reagent, the second reagent, and the diluted solution are installed on the reagent disk 7, and the first reagent and the R2 reagent are dispensed at the timing of dispensing the R1 reagent.
  • the computer 20 controls the dispensing of the diluted solution at the dispensing timing and the second reagent at the dispensing timing of the R3 reagent.
  • the photometer common setting column 75A of the parameter setting column 73A of the application setting screen 71A defines the dispensing amount of each reagent from that of Example 1 shown in FIG. Same except that the item has been deleted.
  • the amount of reagent dispensed with the R1 reagent, R2 reagent, and R3 reagent at the time of measurement can be set separately.
  • the first reagent is “140 [ ⁇ l]” in “R1” and the second reagent is “70 [ ⁇ l]” in “R3”. It is set to be noted.
  • the first reagent is “140 [ ⁇ l]” in “R1”
  • the diluted solution is “35 [ ⁇ l]” in “R2”
  • the second reagent is “35 [ ⁇ l]” in “R3”. It is set to dispense.
  • a reagent disk 7 capable of mounting a plurality of reagent bottles 6 containing a reagent or a diluent is further provided, and the computer 20 is a reagent when measuring with one of the photometers.
  • the reagent dispensing mechanism 12 adds the diluted solution to the reagent in the reaction vessel 9. Also in the automatic analyzer and the analysis method for dispensing and measuring, substantially the same effect as the above-mentioned automatic analyzer and the analysis method of the first embodiment can be obtained.
  • Example 4 As the diluent used in Example 4, a buffer solution having a salt concentration adjusted for dilution of the reagent, which is not involved in the reaction of the sample or the reagent, is assumed.
  • FIG. 9 is a diagram showing an example of an analysis parameter setting screen of the automatic analyzer in the fifth embodiment.
  • the reagents of the first reagent and the second reagent were dispensed to the automatic analyzer of Example 4 in the measurement using the absorptiometer 14 and the measurement using the scattered photometric meter 15.
  • the amount of liquid has been changed so that the reagent amount ratio between the first reagent and the second reagent differs between the measurement with one photometer and the measurement with the other photometer by the computer 20 and the control unit 17.
  • the operation of the reagent dispensing mechanism 12 is controlled.
  • the first reagent is set to “140 [ ⁇ l” in “R1”. ] ”,“ R3 ”is set to dispense“ 70 [ ⁇ l] ”of the second reagent.
  • the first reagent is dispensed into "R1” by "175 [ ⁇ l]” and the second reagent is dispensed into "R3" by "35 [ ⁇ l]”. It is set.
  • a suitable quantification range can be obtained by diluting the second reagent in the measurement with the scattering photometer 15.
  • a suitable quantification range can be obtained by increasing the amount of the first reagent and decreasing the amount of the second reagent.
  • the reagent dispensing mechanism 12 is configured so that the first reagent and the second reagent different from the first reagent can be dispensed into the reaction vessel 9, and the computer 20 and the second reagent can be dispensed.
  • the control unit 17 is an automatic analyzer that controls the operation of the reagent dispensing mechanism 12 so that the reagent amount ratio between the first reagent and the second reagent differs between the measurement by one photometric meter and the measurement by the other photometric meter. And in the analysis method, almost the same effect as the automatic analyzer and the analysis method of the above-mentioned Example 1 can be obtained.
  • Example 6 The automatic analyzer and the analysis method according to the sixth embodiment of the present invention will be described with reference to FIGS. 10 to 12.
  • Examples 1 to 5 when the reagent concentration is suitable for measurement with an absorptiometer, but for measurement with a scattering photometer, an example is shown in which the reagent is diluted and scattered light analysis is performed when the reagent concentration is high. ..
  • Example 6 when the reagent concentration is suitable for measurement with a scattering photometer, but the measurement with an absorptiometer is thin, an example is shown in which the reagent is concentrated for absorption analysis.
  • Reagent concentration can be achieved by controlling the operation of the reagent dispensing mechanism 12 so that the reagent liquid volume ratio between the first reagent and the second reagent is different between the measurement with the scattering photometer and the measurement with the absorptiometer. do.
  • the reagent when measuring with an absorptiometer, the reagent can be concentrated by increasing the ratio of the second reagent to the total amount of the reaction solution as compared with the case of measuring with a scattering photometer.
  • FIG. 10 is a diagram showing an example of the analysis parameter setting screen of the automatic analyzer in the sixth embodiment.
  • the reagent dilution ratio of the scattering photometer dedicated setting column 77 is deleted from that of Example 1 shown in FIG. 3, and the reagent concentration ratio is added to the absorptiometer dedicated setting column 76C. Is the same.
  • An example shows a state in which "1.5" is selected or input as the "reagent concentration ratio" at the time of analysis of the absorptiometer 14.
  • FIG. 11 is an example of a correspondence table in which the combination of the initial measurement condition and the alarm content and the correspondence of the re-examination condition are defined in the inspection flow of this embodiment.
  • the automatic re-examination determination unit 23 selects conditions such as a photometer, a reagent concentration, and a sample amount to be used at the time of re-examination, and requests re-examination.
  • the control unit 17 and the measurement unit 18 control the operation of each unit including the reagent dispensing mechanism 12 so as to execute the re-examination operation.
  • the result of the initial measurement by the absorbance photometer 14 is lower than the lower limit of the "quantification range" set in the absorbance meter dedicated setting column 76C on the analysis parameter of FIG. This is an alarm that occurs when you are. In this case, a re-examination with a scattering photometer 15 capable of measuring a lower concentration is performed.
  • FIG. 12 shows the retest with the absorptiometer 14. It is a flowchart which added the process of determining whether or not to calculate the enrichment ratio used at times.
  • Example 6 is No. 1 in FIG. It is a re-examination flow of 1.
  • step S401 referring to the measurement request information and the analysis parameter information (FIG. 10) input from the input unit 31, when the analysis request method is "scattering analysis", the control unit 17 and the measurement unit 18 are the computer 20. Based on the command signal from, the measurement by the scattered photometer 15 with the undiluted solution suitable for the measurement by the scattered photometer is first carried out (step S401).
  • step S401 the control unit 17 dispenses the reagent 5 of the undiluted solution into the reaction vessel 9 by the reagent dispensing mechanism 12, and the measuring unit 18 stores the measurement data by the scattering photometer 15 in the data storage unit 21.
  • the analysis unit 22 analyzes the measurement data, and the automatic retest determination unit 23 compares the measurement result with the quantitative range of the scattering analysis on the analysis parameters, and the sample concentration is higher than the upper limit of the quantitative range of scattering. Whether or not it is determined (step S402).
  • step S407 the result is output and displayed on the output unit 32 (step S407), and the process is completed.
  • step S403 for re-examination by the absorptiometer 14.
  • step S402 If it is determined in step S402 that the sample concentration is lower than the lower limit of the scattering quantification range, it is considered that the sample concentration does not fall within the quantification range even if the photometer is changed or the reagent is concentrated. In such a case, after step S402 and before step S407, a step of performing a retest under the condition that only the sample concentration is increased without changing the photometer and the reagent concentration is executed.
  • the automatic re-examination determination unit 23 determines whether or not it is necessary to calculate the concentration concentration (concentration rate) (step S403). For example, in this step S403, (i) the reagent is concentrated to a predetermined reagent concentration from the analysis parameter information, and (ii) the reagent concentration ratio is not determined, and the reagent is concentrated to the reagent concentration calculated from the reaction process of the initial measurement. It is determined which of the two methods,, and, is selected.
  • step S405 it is not necessary to calculate the reagent concentration ratio, so the process proceeds to step S405, whereas in the case of (ii), the process proceeds to step S404.
  • the reagent concentration ratio suitable for the absorption analysis is calculated from (step S404), and the process proceeds to step S405.
  • the control unit 17 and the measurement unit 18 perform a re-examination with the absorptiometer 14 (step S405).
  • the computer 20 calculates the reagent dispensing amount according to the reagent concentration ratio in the absorptiometer dedicated setting column 76C of the analysis parameter information (FIG. 10) or the concentration ratio calculated in step S404, and the control unit 17 calculates the reagent dispensing amount.
  • the reagent 5 is dispensed into the reaction vessel 9 by the reagent dispensing mechanism 12 according to the calculated dispensing amount, and the measuring unit 18 stores the measurement result by the absorptiometer 14 in the data storage unit 21.
  • the dispensing amount of the first reagent in the retest by absorption analysis is "105 ⁇ L”
  • the second reagent is. It becomes "105 ⁇ L”.
  • the output unit 32 displays the measurement result by the absorptiometer 14 (step S406), and completes the process.
  • the computer 20 and the control unit 17 perform the analysis by the scattering photometer 15 and the analysis by the absorptiometer 14 with the same kind of reagents at different concentrations.
  • the operation of the reagent dispensing mechanism 12 is controlled.
  • the computer 20 can select whether or not to perform the measurement by one of the scattered photometer 15 and the absorptiometer 14 and perform the re-examination by the other photometer based on the measurement result. Therefore, the measurement is performed by the other photometer only when re-examination is required, and it is possible to suppress the consumption of the sample or the reagent more than necessary.
  • the computer 20 is higher by comparing the measurement result of one photometer with the preset threshold value and determining whether to perform the re-examination by the other photometer based on the comparison result. It is possible to determine the necessity of re-inspection with accuracy.
  • the computer 20 and the control unit 17 dispense the stock solution of the reagent into the reaction vessel 9 by the reagent dispensing mechanism 12 and measure the measurement, and the scattering photometric meter 15 is used. Based on the measurement result of, it is determined whether or not to carry out the measurement by the absorptiometer 14, and when the measurement by the absorptiometer 14 is carried out, the first reagent and the second reagent are concentrated so that the stock solution of the reagent is concentrated.
  • FIG. 13 is a flowchart for determining whether or not to perform the measurement with the absorptiometer 14 first in Example 7 and switch to the scattered photometer 15 to perform the re-examination.
  • Example 7 is No. 1 in FIG. It is a re-examination flow of 2.
  • Example 7 is also an example in which the reagent is concentrated for absorption analysis when the reagent concentration is suitable for measurement with a scattering photometer, but is thin for measurement with an absorptiometer, as in Example 6.
  • Reagent concentration can be achieved by controlling the operation of the reagent dispensing mechanism 12 so that the reagent liquid volume ratio between the first reagent and the second reagent is different between the measurement with the scattering photometer and the measurement with the absorptiometer. do.
  • the reagent when measuring with an absorptiometer, the reagent can be concentrated by increasing the ratio of the second reagent to the total amount of the reaction solution as compared with the case of measuring with a scattering photometer.
  • the computer 20 and the control unit 17 of the seventh embodiment scatter the first reagent and the second reagent so that the second reagent is concentrated by the reagent dispensing mechanism 12 when the measurement by the absorptiometer 14 is performed first. It is measured by dispensing in an amount different from the analysis by the photometer 15, and it is determined whether or not to carry out the measurement by the scattered photometer 15 based on the measurement result of the absorptiometer 14, and the scattered photometer 15 is used.
  • the operation of the reagent dispensing mechanism 12 is controlled so that the stock solution of the reagent (the amount of the solution suitable for the measurement with the scattered photometer 15) is dispensed into the reaction vessel 9 for measurement.
  • Example 7 shown in FIG. 13 is different from the treatment flow in Example 6 shown in FIG. Since the reagent of No. 1 is used, the flow for calculating the concentration ratio is omitted. The details will be described below.
  • control unit 17 dispenses the first reagent and the second reagent into the reaction vessel 9 in an amount different from the analysis by the scattering photometer 15 so that the second reagent is concentrated by the reagent dispensing mechanism 12, and measures the measurement.
  • the unit 18 stores the measurement data by the absorptiometer 14 in the data storage unit 21 (step S501). At this time, the concentration ratio of the reagent dispensed by the reagent dispensing mechanism 12 is set on the analysis parameter.
  • the analysis unit 22 analyzes the measurement data, and the automatic retest determination unit 23 compares the measurement result with the quantitative range of the absorption analysis on the analysis parameters, and the sample concentration is lower than the lower limit of the absorption quantitative range. It is determined whether it is low or not (step S502).
  • step S505 the result is displayed on the output unit 32 (step S505), and the process is terminated.
  • step S503 in order to set the conditions for the scattering analysis.
  • control unit 17 dispenses the sample amount into the reaction vessel 9 with the standard amount by the sample dispensing mechanism 11, and the reagent 5 of the undiluted solution is dispensed into the reaction vessel 9 by the reagent dispensing mechanism 12 (step S503).
  • the measuring unit 18 stores the measurement data by the scattered photometer 15 in the data storage unit 21, and the output unit 32 displays the measurement result of the scattered photometer 15 (step S504) to complete the process.
  • Example 7 almost the same effect as the automatic analyzer and analysis method of Example 6 described above can be obtained.
  • Example 6 the measurement by the scattering photometer 15 was carried out first, and in Example 7, the measurement by the absorptiometer 14 was carried out first, but these can be changed on the analysis parameters. can do. Which measurement should be performed first depends on the tendency of the sample to be measured, the characteristics of the test items / reagents, and the operation policy of the operator, and can be arbitrarily adopted.
  • Example 8 An automatic analyzer and an analysis method according to Example 8 of the present invention will be described with reference to FIG.
  • FIG. 14 is a flowchart showing the operation of the automatic analyzer in the eighth embodiment.
  • Example 6 the measurement was performed with one of the photometers for the first time, and the re-examination was performed with a different photometer based on the result.
  • the absorptiometer 14 The same type of reagent is carried out at different reagent concentrations by both the measurement using the method and the measurement using the scattering photometer 15.
  • Example 3 shows the same contents, when the reagent concentration is suitable for the measurement with the absorptiometer, but the reagent is too dark for the measurement with the scattering photometer, the reagent is diluted and the scattered light is analyzed. showed that.
  • Example 8 when the reagent concentration is suitable for measurement with a scattering photometer, but the measurement with an absorptiometer is thin, an example is shown in which the reagent is concentrated for absorption analysis.
  • Reagent concentration can be achieved by controlling the operation of the reagent dispensing mechanism 12 so that the reagent liquid volume ratio between the first reagent and the second reagent is different between the measurement with the scattering photometer and the measurement with the absorptiometer. do. Specifically, when measuring with an absorptiometer, the reagent can be concentrated by increasing the ratio of the second reagent to the total amount of the reaction solution as compared with the case of measuring with a scattering photometer.
  • the computer 20 and the control unit 17 carry out measurements by both the absorptiometer 14 and the scattered photometer 15, and adopt the measurement results of either photometer based on the measurement results of both photometers. Is determined.
  • control unit 17 dispenses the sample into the two reaction vessels 9 by the sample dispensing mechanism 11, and the concentration ratio set by the reagent dispensing mechanism 12 into the two reaction vessels 9 by the undiluted reagent and the analysis parameters, respectively.
  • Dispense two types of concentrated reagents The reaction vessel 9 to which the undiluted reagent is dispensed is measured by the scattering photometer 15, and the reaction vessel 9 to which the concentrated reagent is dispensed is measured by the absorptiometer 14 (step S601).
  • the analysis unit 22 analyzes the measured data and then determines whether the measured sample concentration is within the quantification range of the scattering photometer 15 and within the quantification range of the absorptiometer 14. It is determined whether or not (step S602).
  • step S602 When it is determined in step S602 that the measurement result is in the low concentration region that is within the quantification range of the scattered photometer 15 and is outside the quantification range of the absorptiometer 14, the analysis unit 22 of the scattering photometer 15 The result is output (step S603), and the process is completed.
  • step S602 when it is determined that the measurement result is in the high concentration region within the quantification range of the absorptiometer 14 and outside the quantification range of the scattered photometer 15, the analysis unit 22 uses the absorptiometer. The result of 14 is output (step S605), and the process is completed.
  • step S602 when it is determined that the measurement result extends over the quantification ranges of both the absorptiometer 14 and the scattered photometer 15, the analysis unit 22 measures the measurement results of both the absorptiometer 14 and the scattered photometer 15. Is output (step S604), and the process is completed.
  • step S604 is not limited to the case of outputting the measurement results of both the absorptiometer 14 and the scattered photometer 15, and outputs the result of either one, which is closer to the middle of the quantification range. It is possible to perform processing such as outputting the average value of the results of.
  • the computer 20 performs measurements with both the absorptiometer 14 and the scattered photometer 15, and either of them is based on the measurement results of both photometers. By determining whether to adopt the measurement result by the photometer, almost the same effect as the above-mentioned automated analyzer and analysis method of the sixth embodiment can be obtained.
  • Application setting screen 72 ... Item selection field 73, 73A, 73B, 73C ... Parameter setting field 75, 75A, 75B, 75C ...
  • Photometer common setting column 76,76A, 76B, 76C Absorption photometer dedicated setting column 77, 77A, 77B, 77C ... Scattered photometer dedicated setting column

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Publication number Priority date Publication date Assignee Title
JP2014006160A (ja) * 2012-06-25 2014-01-16 Hitachi High-Technologies Corp 自動分析装置及び試料測定方法
JP2015021952A (ja) * 2013-07-23 2015-02-02 株式会社日立ハイテクノロジーズ 自動分析装置および分析方法
WO2018016252A1 (ja) * 2016-07-19 2018-01-25 株式会社日立ハイテクノロジーズ 自動分析装置及び自動分析方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014006160A (ja) * 2012-06-25 2014-01-16 Hitachi High-Technologies Corp 自動分析装置及び試料測定方法
JP2015021952A (ja) * 2013-07-23 2015-02-02 株式会社日立ハイテクノロジーズ 自動分析装置および分析方法
WO2018016252A1 (ja) * 2016-07-19 2018-01-25 株式会社日立ハイテクノロジーズ 自動分析装置及び自動分析方法

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