WO2022127631A1 - Procédé de préparation d'une surface poreuse extrêmement lisse pour infuser d'huile de graissage un cathéter médical - Google Patents

Procédé de préparation d'une surface poreuse extrêmement lisse pour infuser d'huile de graissage un cathéter médical Download PDF

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Publication number
WO2022127631A1
WO2022127631A1 PCT/CN2021/135647 CN2021135647W WO2022127631A1 WO 2022127631 A1 WO2022127631 A1 WO 2022127631A1 CN 2021135647 W CN2021135647 W CN 2021135647W WO 2022127631 A1 WO2022127631 A1 WO 2022127631A1
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WO
WIPO (PCT)
Prior art keywords
lubricating oil
ultra
porous surface
curing
smooth porous
Prior art date
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PCT/CN2021/135647
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English (en)
Chinese (zh)
Inventor
赵远锦
孙灵钰
王月桐
商珞然
张大淦
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南京鼓楼医院
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Application filed by 南京鼓楼医院 filed Critical 南京鼓楼医院
Publication of WO2022127631A1 publication Critical patent/WO2022127631A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/10—Materials for lubricating medical devices

Definitions

  • the invention belongs to the technical field of biological materials, and in particular relates to a preparation method of an ultra-smooth porous surface used for lubricating oil perfusion of medical catheters, which can be applied to the technical fields of infusion, dialysis, catheterization and the like.
  • Medical catheters such as urinary catheters, hemodialysis catheters, venous catheters, drainage tubes, etc. are essential components in medical devices, and they usually need to be in direct contact with biological or physiological fluids. Once a medical catheter is contaminated or blocked, patients are at serious risk of infection, even life-threatening. Therefore, it is an urgent problem to develop new catheter materials with good biocompatibility, anticoagulation, antibacterial and anti-adhesion abilities.
  • the present invention provides a preparation method of an ultra-smooth porous surface for lubricating oil perfusion of medical catheters, which can be used for infusion, urinary catheterization and the like, and has good stability and self-healing performance.
  • the purpose of the present invention is to provide a method for preparing an ultra-smooth porous surface for lubricating oil perfusion of medical catheters, aiming at the shortcomings of the traditional wettable catheter surface, such as liquid repellency and anti-bioadhesion properties, which are easily destroyed.
  • the present invention adopts following technical scheme:
  • a method for preparing an ultra-smooth porous surface for lubricating oil infusion of medical catheters comprising the following steps:
  • the polymer precursor is ethoxylated trimethylolpropane triacrylate (ETPTA), polyurethane (PU), polyethylene, polymethyl acrylate (PMA), polybutyl acrylate (PBA) and one of polylactic acid-glycolic acid copolymer (PLGA).
  • ETPTA ethoxylated trimethylolpropane triacrylate
  • PU polyurethane
  • PMA polymethyl acrylate
  • PBA polybutyl acrylate
  • PLGA polylactic acid-glycolic acid copolymer
  • the curing method is ultraviolet light curing, light curing, thermal curing or solvent volatilization curing.
  • the liquid that is incompatible with the polymer precursor solution and cannot be polymerized is one of F108, polyvinyl alcohol (PVA) and sodium dodecyl sulfate (SDS).
  • the curing method when the polymer precursor is ethoxylated trimethylolpropane triacrylate (ETPTA), the curing method is ultraviolet light curing; the polymer precursor is polymethyl acrylate (PMA). ) or polybutyl acrylate (PBA), the curing method is photocuring or thermal curing; when the polymer precursor is polyurethane (PU), polyethylene or polylactic acid-glycolic acid copolymer (PLGA), the curing method is solvent Volatile curing.
  • ETPTA ethoxylated trimethylolpropane triacrylate
  • PMA polymethyl acrylate
  • PBA polybutyl acrylate
  • the curing method is photocuring or thermal curing
  • the polymer precursor when the polymer precursor is polyurethane (PU), polyethylene or polylactic acid-glycolic acid copolymer (PLGA), the curing method is solvent Volatile curing.
  • the inner hole structure of the catheter prepared by S2 is connected with each other and can store a certain amount of lubricating fluid.
  • the lubricating oil is one of perfluoropolyether, paraffin, fluorosilicone oil, mineral oil and ionic liquid.
  • the present invention also provides an ultra-smooth porous surface for lubricating oil perfusion of medical catheters, which is prepared according to the above-mentioned preparation method.
  • the ultra-smooth porous surface of the lubricating fluid perfusion provided by the present invention has good stability, which can reduce the adhesion of water molecules and biomolecules during use, prevent the formation of thrombus, biofilm, etc., and prolong the service life of medical catheters And reduce the risk of infection during use;
  • the present invention adopts the rapid stirring method to prepare the required medical catheter, which is simple and quick to operate, low in cost, suitable for mass production, and greatly expands the practical value of the infiltrating material;
  • the ultra-smooth porous surface perfused with the lubricating liquid provided by the present invention is suitable for various medical instruments such as scalpels and cardiac pacemakers, and exhibits good applicability and market value.
  • A is a schematic diagram of a rapid stirring method to obtain a prepolymer solution dispersed with a large number of droplets
  • B is a schematic diagram of the prepolymer The schematic diagram of the solution pouring into the catheter mold and polymerizing
  • C is the schematic diagram of the porous catheter obtained by washing off the unpolymerized droplets
  • FIG. 2 is a physical diagram of the sliding process of 10 ⁇ l of water droplets on the ultra-smooth porous surface prepared in Example 3 of the present invention.
  • a method for preparing an ultra-smooth porous surface for lubricating oil infusion of medical catheters comprising the following steps:
  • the polymer precursor takes the polymer precursor, prepare it into a polymer precursor solution, add a liquid (F108, polyvinyl alcohol or dodecyl sulfuric acid) that is incompatible with it and cannot be polymerized into the polymer precursor solution sodium), stirring rapidly to form a precursor solution dispersed with a large number of droplets, as shown in A in Figure 1;
  • the polymer precursor is ethoxylated trimethylolpropane triacrylate (ETPTA), One of polyurethane (PU), polyethylene, polymethyl acrylate (PMA), polybutyl acrylate (PBA) and polylactic acid-glycolic acid copolymer (PLGA); curing methods are ultraviolet light curing, light curing, heat curing or solvent volatilization curing;
  • the curing method is ultraviolet light curing; the polymer precursor is polymethyl acrylate (PMA) or When polybutyl acrylate (PBA) is used, the curing method is light curing or thermal curing; when the polymer precursor is polyurethane (PU), polyethylene or polylactic acid-glycolic acid copolymer (PLGA), the curing method is solvent volatilization curing .
  • ETPTA ethoxylated trimethylolpropane triacrylate
  • PMA polymethyl acrylate
  • PBA polybutyl acrylate
  • the curing method is light curing or thermal curing
  • the polymer precursor is polyurethane (PU), polyethylene or polylactic acid-glycolic acid copolymer (PLGA)
  • the curing method is solvent volatilization curing .
  • the lubricating oil is perfluoropolyether, paraffin, fluorosilicone oil, mineral oil and one of ionic liquids.
  • the preparation of hard lubricating oil-filled ultra-slippery porous catheters includes the following steps:
  • the preparation of flexible lubricating oil-infused ultra-smooth porous catheters includes the following steps:

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La présente invention concerne un procédé de préparation d'une surface poreuse extrêmement lisse pour infuser d'huile de graissage un cathéter médical. Le procédé consiste : à obtenir une solution de précurseur contenant un grand nombre de gouttelettes non miscibles sur la base d'un procédé d'agitation rapide ; puis, à introduire la solution dans un moule tubulaire, à durcir et à laver la partie non polymérisée pour obtenir un cathéter ayant une structure poreuse, puis à infiltrer la structure poreuse et sa surface avec de l'huile de graissage afin d'obtenir une surface poreuse extrêmement lisse pour infuser d'huile de graissage un cathéter médical. Selon la présente invention, la surface du cathéter préparée est recouverte d'une huile de graissage chimiquement inerte et offre ainsi une certaine efficacité d'auto-réparation et peut éviter efficacement l'adhérence de composants biologiques tels que des bactéries et des protéines pendant une longue durée. Le procédé de préparation de la présente invention est simple et rapide, présente une stabilité élevée et une longue durée de vie ; de plus, la surface fonctionnelle préparée est appropriée pour des cathéters médicaux et des instruments chirurgicaux, etc. et revêt une grande importance pour élargir la valeur biomédicale de matériaux mouillables.
PCT/CN2021/135647 2020-12-18 2021-12-06 Procédé de préparation d'une surface poreuse extrêmement lisse pour infuser d'huile de graissage un cathéter médical WO2022127631A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202011509397.9A CN112472877B (zh) 2020-12-18 2020-12-18 用于医疗导管的润滑油灌注的超滑多孔表面的制备方法
CN202011509397.9 2020-12-18

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CN113616859A (zh) * 2021-07-08 2021-11-09 深圳先进技术研究院 一种抗菌润滑涂层及其制备方法和应用
CN113528010A (zh) * 2021-08-27 2021-10-22 电子科技大学 一种具有长效疏冰特性的超滑涂层的制备及其应用

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