WO2022127631A1 - Preparation method for ultra-smooth porous surface for lubricating oil infusion of medical catheter - Google Patents

Preparation method for ultra-smooth porous surface for lubricating oil infusion of medical catheter Download PDF

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WO2022127631A1
WO2022127631A1 PCT/CN2021/135647 CN2021135647W WO2022127631A1 WO 2022127631 A1 WO2022127631 A1 WO 2022127631A1 CN 2021135647 W CN2021135647 W CN 2021135647W WO 2022127631 A1 WO2022127631 A1 WO 2022127631A1
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lubricating oil
ultra
porous surface
curing
smooth porous
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PCT/CN2021/135647
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French (fr)
Chinese (zh)
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赵远锦
孙灵钰
王月桐
商珞然
张大淦
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南京鼓楼医院
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/10—Materials for lubricating medical devices

Definitions

  • the invention belongs to the technical field of biological materials, and in particular relates to a preparation method of an ultra-smooth porous surface used for lubricating oil perfusion of medical catheters, which can be applied to the technical fields of infusion, dialysis, catheterization and the like.
  • Medical catheters such as urinary catheters, hemodialysis catheters, venous catheters, drainage tubes, etc. are essential components in medical devices, and they usually need to be in direct contact with biological or physiological fluids. Once a medical catheter is contaminated or blocked, patients are at serious risk of infection, even life-threatening. Therefore, it is an urgent problem to develop new catheter materials with good biocompatibility, anticoagulation, antibacterial and anti-adhesion abilities.
  • the present invention provides a preparation method of an ultra-smooth porous surface for lubricating oil perfusion of medical catheters, which can be used for infusion, urinary catheterization and the like, and has good stability and self-healing performance.
  • the purpose of the present invention is to provide a method for preparing an ultra-smooth porous surface for lubricating oil perfusion of medical catheters, aiming at the shortcomings of the traditional wettable catheter surface, such as liquid repellency and anti-bioadhesion properties, which are easily destroyed.
  • the present invention adopts following technical scheme:
  • a method for preparing an ultra-smooth porous surface for lubricating oil infusion of medical catheters comprising the following steps:
  • the polymer precursor is ethoxylated trimethylolpropane triacrylate (ETPTA), polyurethane (PU), polyethylene, polymethyl acrylate (PMA), polybutyl acrylate (PBA) and one of polylactic acid-glycolic acid copolymer (PLGA).
  • ETPTA ethoxylated trimethylolpropane triacrylate
  • PU polyurethane
  • PMA polymethyl acrylate
  • PBA polybutyl acrylate
  • PLGA polylactic acid-glycolic acid copolymer
  • the curing method is ultraviolet light curing, light curing, thermal curing or solvent volatilization curing.
  • the liquid that is incompatible with the polymer precursor solution and cannot be polymerized is one of F108, polyvinyl alcohol (PVA) and sodium dodecyl sulfate (SDS).
  • the curing method when the polymer precursor is ethoxylated trimethylolpropane triacrylate (ETPTA), the curing method is ultraviolet light curing; the polymer precursor is polymethyl acrylate (PMA). ) or polybutyl acrylate (PBA), the curing method is photocuring or thermal curing; when the polymer precursor is polyurethane (PU), polyethylene or polylactic acid-glycolic acid copolymer (PLGA), the curing method is solvent Volatile curing.
  • ETPTA ethoxylated trimethylolpropane triacrylate
  • PMA polymethyl acrylate
  • PBA polybutyl acrylate
  • the curing method is photocuring or thermal curing
  • the polymer precursor when the polymer precursor is polyurethane (PU), polyethylene or polylactic acid-glycolic acid copolymer (PLGA), the curing method is solvent Volatile curing.
  • the inner hole structure of the catheter prepared by S2 is connected with each other and can store a certain amount of lubricating fluid.
  • the lubricating oil is one of perfluoropolyether, paraffin, fluorosilicone oil, mineral oil and ionic liquid.
  • the present invention also provides an ultra-smooth porous surface for lubricating oil perfusion of medical catheters, which is prepared according to the above-mentioned preparation method.
  • the ultra-smooth porous surface of the lubricating fluid perfusion provided by the present invention has good stability, which can reduce the adhesion of water molecules and biomolecules during use, prevent the formation of thrombus, biofilm, etc., and prolong the service life of medical catheters And reduce the risk of infection during use;
  • the present invention adopts the rapid stirring method to prepare the required medical catheter, which is simple and quick to operate, low in cost, suitable for mass production, and greatly expands the practical value of the infiltrating material;
  • the ultra-smooth porous surface perfused with the lubricating liquid provided by the present invention is suitable for various medical instruments such as scalpels and cardiac pacemakers, and exhibits good applicability and market value.
  • A is a schematic diagram of a rapid stirring method to obtain a prepolymer solution dispersed with a large number of droplets
  • B is a schematic diagram of the prepolymer The schematic diagram of the solution pouring into the catheter mold and polymerizing
  • C is the schematic diagram of the porous catheter obtained by washing off the unpolymerized droplets
  • FIG. 2 is a physical diagram of the sliding process of 10 ⁇ l of water droplets on the ultra-smooth porous surface prepared in Example 3 of the present invention.
  • a method for preparing an ultra-smooth porous surface for lubricating oil infusion of medical catheters comprising the following steps:
  • the polymer precursor takes the polymer precursor, prepare it into a polymer precursor solution, add a liquid (F108, polyvinyl alcohol or dodecyl sulfuric acid) that is incompatible with it and cannot be polymerized into the polymer precursor solution sodium), stirring rapidly to form a precursor solution dispersed with a large number of droplets, as shown in A in Figure 1;
  • the polymer precursor is ethoxylated trimethylolpropane triacrylate (ETPTA), One of polyurethane (PU), polyethylene, polymethyl acrylate (PMA), polybutyl acrylate (PBA) and polylactic acid-glycolic acid copolymer (PLGA); curing methods are ultraviolet light curing, light curing, heat curing or solvent volatilization curing;
  • the curing method is ultraviolet light curing; the polymer precursor is polymethyl acrylate (PMA) or When polybutyl acrylate (PBA) is used, the curing method is light curing or thermal curing; when the polymer precursor is polyurethane (PU), polyethylene or polylactic acid-glycolic acid copolymer (PLGA), the curing method is solvent volatilization curing .
  • ETPTA ethoxylated trimethylolpropane triacrylate
  • PMA polymethyl acrylate
  • PBA polybutyl acrylate
  • the curing method is light curing or thermal curing
  • the polymer precursor is polyurethane (PU), polyethylene or polylactic acid-glycolic acid copolymer (PLGA)
  • the curing method is solvent volatilization curing .
  • the lubricating oil is perfluoropolyether, paraffin, fluorosilicone oil, mineral oil and one of ionic liquids.
  • the preparation of hard lubricating oil-filled ultra-slippery porous catheters includes the following steps:
  • the preparation of flexible lubricating oil-infused ultra-smooth porous catheters includes the following steps:

Abstract

The present invention provides a preparation method for an ultra-smooth porous surface for lubricating oil infusion of a medical catheter. The method comprises: obtaining a precursor solution containing a large number of immiscible droplets on the basis of a rapid stirring method; and then, introducing the solution into a tube mold, curing, and washing off the unpolymerized portion to obtain a catheter having a porous structure, and then infiltrating the porous structure and the surface thereof with lubricating oil to obtain an ultra-smooth porous surface for lubricating oil infusion of a medical catheter. According to the present invention, the prepared catheter surface is covered with chemically inert lubricating oil, and thus has certain self-repairing performance, and can effectively avoid adhesion of biological components such as bacteria and proteins for a long time. The preparation method of the present invention is simple and rapid, high in stability, and long in service life; moreover, the prepared functional surface is suitable for medical catheters and surgical instruments, etc., and has important significance for broadening the biomedical value of wettable materials.

Description

用于医疗导管的润滑油灌注的超滑多孔表面的制备方法Preparation method of ultra-smooth porous surface for lubricating oil infusion of medical catheters 技术领域technical field
本发明属于生物材料技术领域，具体涉及一种用于医疗导管的润滑油灌注的超滑多孔表面的制备方法，可应用于输液、透析、导尿等技术领域。The invention belongs to the technical field of biological materials, and in particular relates to a preparation method of an ultra-smooth porous surface used for lubricating oil perfusion of medical catheters, which can be applied to the technical fields of infusion, dialysis, catheterization and the like.
背景技术Background technique
医疗导管如导尿管、血液透析导管、静脉导管、引流管等是医疗器械中必不可少的组成部分，它们通常需要与生物体或生理液体进行直接接触。一旦医用导管被污染或堵塞，患者就有严重的感染风险，甚至会危及生命。因此，开发出具有良好生物相容性、抗凝血、抗菌和抗粘连能力的新型导管材料亟待解决的问题。Medical catheters such as urinary catheters, hemodialysis catheters, venous catheters, drainage tubes, etc. are essential components in medical devices, and they usually need to be in direct contact with biological or physiological fluids. Once a medical catheter is contaminated or blocked, patients are at serious risk of infection, even life-threatening. Therefore, it is an urgent problem to develop new catheter materials with good biocompatibility, anticoagulation, antibacterial and anti-adhesion abilities.
界面科学的发展为医疗导管的改进注入了新的活力。研究人员通过物理或化学方法修改医用导管的表面形貌和化学成分，已经制备出许多具有超浸润性能如超疏水的医疗导管。然而，这些医用导管的超浸润性能容易遭到破坏，使用寿命较短。润滑液灌注的超滑多孔表面由于其出色的拒液性、一定的自修复性能和良好的透光性等成为了构建医用导管的理想材料。Advances in interface science have injected new energy into the improvement of medical catheters. By modifying the surface morphology and chemical composition of medical catheters by physical or chemical methods, researchers have prepared many medical catheters with super-wetting properties such as super-hydrophobicity. However, the super-wetting properties of these medical catheters are easily destroyed and their service life is short. The ultra-smooth porous surface infused with lubricating fluid has become an ideal material for the construction of medical catheters due to its excellent liquid repellency, certain self-healing properties and good light transmittance.
因此，本发明提供一种用于医疗导管的润滑油灌注的超滑多孔表面的制备方法，可用于输液、导尿等方面，具有良好的稳定性和自修复性能。Therefore, the present invention provides a preparation method of an ultra-smooth porous surface for lubricating oil perfusion of medical catheters, which can be used for infusion, urinary catheterization and the like, and has good stability and self-healing performance.
发明内容SUMMARY OF THE INVENTION
本发明的目的是针对传统的浸润性导管表面的拒液以及抗生物黏附性能等容易被破坏的缺点，提供一种用于医疗导管的润滑油灌注的超滑多孔表面的制备方法。The purpose of the present invention is to provide a method for preparing an ultra-smooth porous surface for lubricating oil perfusion of medical catheters, aiming at the shortcomings of the traditional wettable catheter surface, such as liquid repellency and anti-bioadhesion properties, which are easily destroyed.
本发明采用以下技术方案：The present invention adopts following technical scheme:
一种用于医疗导管的润滑油灌注的超滑多孔表面的制备方法，包括以下步骤：A method for preparing an ultra-smooth porous surface for lubricating oil infusion of medical catheters, comprising the following steps:
S1、取聚合物前聚体，配制成聚合物前聚体溶液，在聚合物前聚体溶液中加入一种与其不相溶且无法聚合的液体，快速搅拌，形成分散有大量液滴的前聚体溶液；S1. Take the polymer precursor, prepare it into a polymer precursor solution, add a liquid that is incompatible with it and cannot be polymerized into the polymer precursor solution, and stir rapidly to form a precursor with a large number of droplets dispersed. polymer solution;
S2、将S1制备的溶液倒入导管模具中，进行固化聚合，随后用水和酒精充分洗去未聚合的液滴，即得到具有孔洞结构的导管；S2. Pour the solution prepared in S1 into the catheter mold, and perform solidification and polymerization, and then fully wash off the unpolymerized droplets with water and alcohol to obtain a catheter with a hole structure;
S3、将S2制备的导管孔洞内部及表面浸润一层化学惰性的润滑油，得到用于医疗导管的润滑油灌注的超滑多孔表面。S3, infiltrating a layer of chemically inert lubricating oil inside and on the surface of the catheter hole prepared in S2 to obtain an ultra-smooth porous surface for lubricating oil perfusion for medical catheters.
进一步的，S1中，所述聚合物前聚体为乙氧基化三羟甲基丙烷三丙烯酸酯(ETPTA)、聚氨酯(PU)、聚乙烯、聚丙烯酸甲酯(PMA)、聚丙烯酸丁酯(PBA)及聚乳酸-羟基乙酸共聚物(PLGA)中的一种。Further, in S1, the polymer precursor is ethoxylated trimethylolpropane triacrylate (ETPTA), polyurethane (PU), polyethylene, polymethyl acrylate (PMA), polybutyl acrylate (PBA) and one of polylactic acid-glycolic acid copolymer (PLGA).
进一步的，S1中，固化方式为紫外光固化、光固化、热固化或者溶剂挥发固化。Further, in S1, the curing method is ultraviolet light curing, light curing, thermal curing or solvent volatilization curing.
进一步的，S1中，与聚合物前聚体溶液不相溶且无法聚合的液体为F108、聚乙烯醇(PVA)及十二烷基硫酸钠(SDS)中的一种。Further, in S1, the liquid that is incompatible with the polymer precursor solution and cannot be polymerized is one of F108, polyvinyl alcohol (PVA) and sodium dodecyl sulfate (SDS).
进一步的，S1中，所述聚合物前聚体采用乙氧基化三羟甲基丙烷三丙烯酸酯(ETPTA)时，固化方式为紫外光固化；聚合物前聚体为聚丙烯酸甲酯(PMA)或者聚丙烯酸丁酯(PBA)时，固化方式为光固化或热固化；聚合物前聚体为聚氨酯(PU)、聚乙烯或者聚乳酸-羟基乙酸共聚物(PLGA)时，固化方式为溶剂挥发固化。Further, in S1, when the polymer precursor is ethoxylated trimethylolpropane triacrylate (ETPTA), the curing method is ultraviolet light curing; the polymer precursor is polymethyl acrylate (PMA). ) or polybutyl acrylate (PBA), the curing method is photocuring or thermal curing; when the polymer precursor is polyurethane (PU), polyethylene or polylactic acid-glycolic acid copolymer (PLGA), the curing method is solvent Volatile curing.
进一步的，S2所制备的导管内部孔洞结构相互连通，能够存储一定量的润滑液。Further, the inner hole structure of the catheter prepared by S2 is connected with each other and can store a certain amount of lubricating fluid.
进一步的，S3中，润滑油为全氟聚醚、石蜡、氟硅油、矿物油及离子液体中的一种。Further, in S3, the lubricating oil is one of perfluoropolyether, paraffin, fluorosilicone oil, mineral oil and ionic liquid.
本发明还提供一种用于医疗导管的润滑油灌注的超滑多孔表面，根据以上所述制备方法制备而成。The present invention also provides an ultra-smooth porous surface for lubricating oil perfusion of medical catheters, which is prepared according to the above-mentioned preparation method.
本发明的有益效果：Beneficial effects of the present invention:
(1)本发明提供的润滑液灌注的超滑多孔表面具有良好的稳定性，能够减少使用过程中水分子及生物分子的黏附，防止血栓、菌膜等的形成，延长了医疗导管的使用寿命并降低了使用过程中感染的风险；(1) The ultra-smooth porous surface of the lubricating fluid perfusion provided by the present invention has good stability, which can reduce the adhesion of water molecules and biomolecules during use, prevent the formation of thrombus, biofilm, etc., and prolong the service life of medical catheters And reduce the risk of infection during use;
(2)本发明采用快速搅拌法制备所需的医疗导管，操作简便快捷，成本低廉，适合量产，极大地拓展了浸润性材料的实用价值；(2) The present invention adopts the rapid stirring method to prepare the required medical catheter, which is simple and quick to operate, low in cost, suitable for mass production, and greatly expands the practical value of the infiltrating material;
(3)本发明提供的润滑液灌注的超滑多孔表面适用于手术刀、心脏起搏器多种医疗器械，展现出良好的适用性和市场价值。(3) The ultra-smooth porous surface perfused with the lubricating liquid provided by the present invention is suitable for various medical instruments such as scalpels and cardiac pacemakers, and exhibits good applicability and market value.
附图说明Description of drawings
图1为本发明用于医疗导管的润滑油灌注的超滑多孔表面及其制备过程示意图；其中，A为快速搅拌法获得分散有大量液滴的前聚体溶液示意图，B为将前聚体溶液倒入导管模具并聚合的示意图；C为洗去未聚合液滴得到的多孔导管示意图；1 is a schematic diagram of an ultra-smooth porous surface used for lubricating lubricating oil perfusion of medical catheters according to the present invention and its preparation process; wherein, A is a schematic diagram of a rapid stirring method to obtain a prepolymer solution dispersed with a large number of droplets, and B is a schematic diagram of the prepolymer The schematic diagram of the solution pouring into the catheter mold and polymerizing; C is the schematic diagram of the porous catheter obtained by washing off the unpolymerized droplets;
图2为10μl的水滴在本发明实施例3所制备的超滑多孔表面滑动过程实物图。FIG. 2 is a physical diagram of the sliding process of 10 μl of water droplets on the ultra-smooth porous surface prepared in Example 3 of the present invention.
具体实施方式：Detailed ways:
为使本发明实施例的目的、技术方案和优点更加清楚，下面将结合本发明实施例及附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例是本发明的一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动的前提下所获得的所有其他实施例，都属于本发明保护的范围。实施例中未注明的实 施条件通常为常规实验中的条件。In order to make the purposes, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention and the accompanying drawings. Obviously, the described embodiments are Some, but not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work fall within the protection scope of the present invention. The implementation conditions not specified in the examples are usually the conditions in routine experiments.
一种用于医疗导管的润滑油灌注的超滑多孔表面的制备方法，包括以下步骤：A method for preparing an ultra-smooth porous surface for lubricating oil infusion of medical catheters, comprising the following steps:
S1、取聚合物前聚体，配制成聚合物前聚体溶液，在聚合物前聚体溶液中加入一种与其不相溶且无法聚合的液体(F108、聚乙烯醇或十二烷基硫酸钠)，快速搅拌，形成分散有大量液滴的前聚体溶液，如图1中A所示；所述聚合物前聚体为乙氧基化三羟甲基丙烷三丙烯酸酯(ETPTA)、聚氨酯(PU)、聚乙烯、聚丙烯酸甲酯(PMA)、聚丙烯酸丁酯(PBA)及聚乳酸-羟基乙酸共聚物(PLGA)中的一种；固化方式为紫外光固化、光固化、热固化或者溶剂挥发固化；S1, take the polymer precursor, prepare it into a polymer precursor solution, add a liquid (F108, polyvinyl alcohol or dodecyl sulfuric acid) that is incompatible with it and cannot be polymerized into the polymer precursor solution sodium), stirring rapidly to form a precursor solution dispersed with a large number of droplets, as shown in A in Figure 1; the polymer precursor is ethoxylated trimethylolpropane triacrylate (ETPTA), One of polyurethane (PU), polyethylene, polymethyl acrylate (PMA), polybutyl acrylate (PBA) and polylactic acid-glycolic acid copolymer (PLGA); curing methods are ultraviolet light curing, light curing, heat curing or solvent volatilization curing;
具体的，所述的聚合物前聚体采用乙氧基化三羟甲基丙烷三丙烯酸酯(ETPTA)时，固化方式为紫外光固化；聚合物前聚体为聚丙烯酸甲酯(PMA)或者聚丙烯酸丁酯(PBA)时，固化方式为光固化或热固化；聚合物前聚体为聚氨酯(PU)、聚乙烯或者聚乳酸-羟基乙酸共聚物(PLGA)时，固化方式为溶剂挥发固化。Specifically, when the polymer precursor is ethoxylated trimethylolpropane triacrylate (ETPTA), the curing method is ultraviolet light curing; the polymer precursor is polymethyl acrylate (PMA) or When polybutyl acrylate (PBA) is used, the curing method is light curing or thermal curing; when the polymer precursor is polyurethane (PU), polyethylene or polylactic acid-glycolic acid copolymer (PLGA), the curing method is solvent volatilization curing .
S2、将S1制备的溶液倒入导管模具中，进行固化，如图1中B所示，随后用水和酒精充分洗去未聚合的液滴，即得到具有孔洞结构的导管，如图1中C所示；导管内部孔洞结构相互连通，能够存储一定量的润滑液。S2. Pour the solution prepared in S1 into the conduit mold for curing, as shown in B in Figure 1, and then fully wash off the unpolymerized droplets with water and alcohol to obtain a conduit with a hole structure, as shown in C in Figure 1 As shown; the inner hole structure of the conduit is connected with each other and can store a certain amount of lubricating fluid.
S3、将S2制备的导管孔洞内部及表面浸润一层化学惰性的润滑油，得到用于医疗导管的润滑油灌注的超滑多孔表面；润滑油为全氟聚醚、石蜡、氟硅油、矿物油及离子液体中的一种。S3. Infiltrate the inside and surface of the catheter hole prepared by S2 with a layer of chemically inert lubricating oil to obtain an ultra-smooth porous surface for lubricating oil perfusion for medical catheters; the lubricating oil is perfluoropolyether, paraffin, fluorosilicone oil, mineral oil and one of ionic liquids.
实施例1Example 1
硬性润滑油灌注的超滑多孔导管的制备，包括以下步骤：The preparation of hard lubricating oil-filled ultra-slippery porous catheters includes the following steps:
S1、在离心管中配制含有1％(v/v)光引发剂(2-羟基-2-甲基苯丙酮)的乙氧基化三羟甲基丙烷三丙烯酸酯(ETPTA)溶液，之后加入2％(w/v)F108溶液，快速搅拌该溶液，形成分散有大量液滴的前聚体溶液。S1. Prepare a solution of ethoxylated trimethylolpropane triacrylate (ETPTA) containing 1% (v/v) photoinitiator (2-hydroxy-2-methylpropiophenone) in a centrifuge tube, and then add 2% (w/v) solution of F108, which was stirred rapidly to form a solution of the precursor with a large number of droplets dispersed.
S2、将形成的分散有大量液滴的前聚体溶液倒入导管模具中，利用365nm波段的紫外光进行聚合，之后用水和酒精充分洗去未聚合的液滴即得到具有孔洞结构的管道。S2. Pour the formed prepolymer solution dispersed with a large number of droplets into the conduit mold, use ultraviolet light in the 365nm band to polymerize, and then fully wash off the unpolymerized droplets with water and alcohol to obtain a conduit with a hole structure.
S3、将制备得到的管道泡在氟硅油溶液中，使其孔洞内部及表面浸润一层氟硅油，得到用于医疗导管的润滑油灌注的超滑表面。S3, soaking the prepared pipe in a fluorosilicone oil solution to infiltrate a layer of fluorosilicone oil inside and on the surface of the hole to obtain an ultra-smooth surface for lubricating oil perfusion for medical catheters.
实施例2Example 2
柔性润滑油灌注的超滑多孔导管的制备，包括以下步骤：The preparation of flexible lubricating oil-infused ultra-smooth porous catheters includes the following steps:
S1、在离心管中配制20％(w/v)的聚氨酯(PU)溶液，之后加入液体石蜡溶液，快速搅 拌该溶液，形成分散有大量液滴的前聚体溶液。S1. Prepare a 20% (w/v) polyurethane (PU) solution in a centrifuge tube, then add a liquid paraffin solution, and stir the solution rapidly to form a precursor solution with a large number of droplets dispersed.
S2、将形成的分散有大量液滴的前聚体溶液倒入导管模具中，放在60℃热台上加热进行溶剂挥发，得到用于医疗导管的润滑油灌注的超滑表面。S2. Pour the formed precursor solution dispersed with a large number of droplets into a catheter mold, and place it on a 60° C. hot stage to heat for solvent volatilization to obtain an ultra-smooth surface for lubricating oil perfusion for medical catheters.
实施例3Example 3
润滑油灌注的超滑多孔导管的浸润性测试：Wetability Testing of Lubricated Ultra-Smooth Porous Catheters:
取10μl的水滴滴在实施例1所制备的医疗导管表面并进行缓慢倾斜，记录水滴开始滑动的角度(即滑动角)，结果表明滑动角小于5°，如图2所示。10 μl of water droplets were dropped on the surface of the medical catheter prepared in Example 1 and slowly tilted, and the angle at which the water droplets began to slide (ie, the sliding angle) was recorded. The results showed that the sliding angle was less than 5°, as shown in Figure 2.
以上仅是本发明的优选实施方式，本发明的保护范围并不仅局限于上述实施例，凡属于本发明思路下的技术方案均属于本发明的保护范围，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明原理前提下的若干改进和润饰，应视为本发明的保护范围。The above are only the preferred embodiments of the present invention, and the protection scope of the present invention is not limited to the above-mentioned embodiments. All technical solutions under the idea of the present invention belong to the protection scope of the present invention. For personnel, several improvements and modifications without departing from the principles of the present invention should be regarded as the protection scope of the present invention.

Claims (8)

  1. 一种用于医疗导管的润滑油灌注的超滑多孔表面的制备方法，其特征在于，包括以下步骤：A method for preparing an ultra-smooth porous surface for lubricating oil perfusion of medical catheters, comprising the following steps:
    S1、取聚合物前聚体，配制成聚合物前聚体溶液，在聚合物前聚体溶液中加入一种与其不相溶且无法聚合的液体，快速搅拌，形成分散有大量液滴的前聚体溶液；S1. Take the polymer precursor, prepare it into a polymer precursor solution, add a liquid that is incompatible with it and cannot be polymerized into the polymer precursor solution, and stir rapidly to form a precursor with a large number of droplets dispersed. polymer solution;
    S2、将S1制备的溶液倒入导管模具中，进行固化，随后用水和酒精充分洗去未聚合的液滴，即得到具有孔洞结构的导管；S2. Pour the solution prepared in S1 into the catheter mold, solidify, and then fully wash off the unpolymerized droplets with water and alcohol to obtain a catheter with a hole structure;
    S3、将S2制备的导管孔洞内部及表面浸润一层化学惰性的润滑油，得到用于医疗导管的润滑油灌注的超滑多孔表面。S3, infiltrating a layer of chemically inert lubricating oil inside and on the surface of the catheter hole prepared in S2 to obtain an ultra-smooth porous surface for lubricating oil perfusion for medical catheters.
  2. 根据权利要求1所述的用于医疗导管的润滑油灌注的超滑多孔表面的制备方法，其特征在于，S1中，所述聚合物前聚体为乙氧基化三羟甲基丙烷三丙烯酸酯、聚氨酯、聚乙烯、聚丙烯酸甲酯、聚丙烯酸丁酯及聚乳酸-羟基乙酸共聚物中的一种。The method for preparing an ultra-smooth porous surface for lubricating oil perfusion of medical catheters according to claim 1, wherein in S1, the polymer precursor is ethoxylated trimethylolpropane triacrylic acid A kind of ester, polyurethane, polyethylene, polymethyl acrylate, polybutyl acrylate and polylactic acid-glycolic acid copolymer.
  3. 根据权利要求1所述的用于医疗导管的润滑油灌注的超滑多孔表面的制备方法，其特征在于，S1中，固化方式为紫外光固化、光固化、热固化或者溶剂挥发固化。The method for preparing an ultra-smooth porous surface for lubricating oil perfusion of medical catheters according to claim 1, wherein, in S1, the curing method is ultraviolet curing, light curing, thermal curing or solvent volatilization curing.
  4. 根据权利要求1所述的用于医疗导管的润滑油灌注的超滑多孔表面的制备方法，其特征在于，S1中，与聚合物前聚体溶液不相溶且无法聚合的液体为F108、聚乙烯醇及十二烷基硫酸钠中的一种。The method for preparing an ultra-smooth porous surface for lubricating oil perfusion of medical catheters according to claim 1, wherein in S1, the liquid that is incompatible with the polymer precursor solution and cannot be polymerized is F108, polymer One of vinyl alcohol and sodium lauryl sulfate.
  5. 根据权利要求2所述的用于医疗导管的润滑油灌注的超滑多孔表面的制备方法，其特征在于，S1中，所述聚合物前聚体采用乙氧基化三羟甲基丙烷三丙烯酸酯时，固化方式为紫外光固化；聚合物前聚体为聚丙烯酸甲酯或者聚丙烯酸丁酯时，固化方式为光固化或热固化；聚合物前聚体为聚氨酯、聚乙烯或者聚乳酸-羟基乙酸共聚物时，固化方式为溶剂挥发固化。The method for preparing an ultra-smooth porous surface for lubricating oil perfusion of medical catheters according to claim 2, wherein in S1, the polymer precursor is ethoxylated trimethylolpropane triacrylic acid. When the polymer precursor is polymethyl acrylate or polybutyl acrylate, the curing method is light curing or thermal curing; the polymer precursor is polyurethane, polyethylene or polylactic acid- In the case of glycolic acid copolymer, the curing method is solvent volatilization curing.
  6. 根据权利要求1所述的用于医疗导管的润滑油灌注的超滑多孔表面的制备方法，其特征在于，S2所制备的导管内部孔洞结构相互连通，能够存储一定量的润滑液。The method for preparing an ultra-smooth porous surface for lubricating oil perfusion of medical catheters according to claim 1, wherein the inner hole structures of the catheter prepared by S2 are connected with each other and can store a certain amount of lubricating liquid.
  7. 根据权利要求1所述的用于医疗导管的润滑油灌注的超滑多孔表面的制备方法，其特征在于，S3中，润滑油为全氟聚醚、石蜡、氟硅油、矿物油及离子液体中的一种。The method for preparing an ultra-smooth porous surface for lubricating oil perfusion of medical catheters according to claim 1, wherein in S3, the lubricating oil is perfluoropolyether, paraffin, fluorosilicone oil, mineral oil and ionic liquid a kind of.
  8. 一种用于医疗导管的润滑油灌注的超滑多孔表面，其特征在于，根据权利要求1～7任意一项所述制备方法制备而成。An ultra-smooth porous surface for lubricating oil perfusion of medical catheters, characterized in that it is prepared according to the preparation method of any one of claims 1-7.
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