CN112472877B - Method for preparing lubricating oil-infused ultra-smooth porous surface for medical catheter - Google Patents
Method for preparing lubricating oil-infused ultra-smooth porous surface for medical catheter Download PDFInfo
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- CN112472877B CN112472877B CN202011509397.9A CN202011509397A CN112472877B CN 112472877 B CN112472877 B CN 112472877B CN 202011509397 A CN202011509397 A CN 202011509397A CN 112472877 B CN112472877 B CN 112472877B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/146—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/10—Materials for lubricating medical devices
Abstract
The invention provides a preparation method of a lubricating oil-infused super-smooth porous surface for a medical catheter, which is characterized in that a polymer prepolymer solution containing a large number of immiscible droplets is obtained based on a rapid stirring method, then the solution is introduced into a pipeline mold, the non-polymerized part is washed off after solidification to obtain a catheter with a porous structure, and then the porous structure and the surface of the catheter are infiltrated by lubricating liquid to obtain the lubricating oil-infused super-smooth porous surface for the medical catheter. The surface of the conduit prepared by the invention is covered by chemically inert lubricating oil, has certain self-repairing performance, and can effectively prevent the adhesion of biological components such as bacteria, protein and the like for a long time. The preparation method is simple and rapid, has strong stability and long service life, and the prepared functional surface is suitable for medical catheters, surgical instruments and the like, and has important significance for widening the biomedical value of the infiltrative material.
Description
Technical Field
The invention belongs to the technical field of biological materials, and particularly relates to a preparation method of a super-smooth porous surface for lubricating oil perfusion of a medical catheter, which can be applied to the technical fields of transfusion, dialysis, catheterization and the like.
Background
Medical catheters, such as urinary catheters, hemodialysis catheters, venous catheters, drainage tubes, etc., are indispensable components of medical devices, which usually require direct contact with living organisms or physiological fluids. Once a medical catheter becomes contaminated or clogged, the patient is at a serious risk of infection and even life threatening. Therefore, there is a need to develop new catheter materials with good biocompatibility, anticoagulant, antibacterial and anti-adhesion capabilities.
The development of interface science has injected new viability into the development of medical catheters. Researchers have prepared many medical catheters with super-wetting properties, such as super-hydrophobicity, by modifying the surface topography and chemical composition of medical catheters by physical or chemical means. However, these medical catheters are susceptible to deterioration of their super-wetting properties and short service lives. The lubricating liquid-filled ultra-smooth porous surface becomes an ideal material for constructing the medical catheter due to the excellent liquid repellency, certain self-repairing performance, good light transmittance and the like.
Therefore, the invention provides a preparation method of the lubricating oil-filled super-smooth porous surface for the medical catheter, which can be used for infusion, catheterization and the like and has good stability and self-repairing performance.
Disclosure of Invention
The invention aims to provide a preparation method of a super-smooth porous surface for lubricating oil perfusion of a medical catheter, aiming at the defects that the liquid repellency, the anti-biological adhesion performance and the like of the surface of the traditional wetting catheter are easy to damage.
The invention adopts the following technical scheme:
a method of preparing a lubricant infused ultra-smooth porous surface for a medical catheter comprising the steps of:
s1, taking a polymer precursor, preparing a polymer precursor solution, adding a liquid which is immiscible with the polymer precursor solution and can not be polymerized into the polymer precursor solution, and quickly stirring to form a precursor solution dispersed with a large number of liquid drops;
s2, pouring the solution prepared in the S1 into a catheter mould, carrying out solidification polymerization, and then fully washing unpolymerized liquid drops by water and alcohol to obtain a catheter with a hole structure;
and S3, infiltrating a layer of chemically inert lubricating oil into the inside and the surface of the hole of the catheter prepared in the step S2 to obtain the super-smooth porous surface for lubricating oil perfusion of the medical catheter.
Further, in S1, the polymer prepolymer is one of ethoxylated trimethylolpropane triacrylate (ETPTA), Polyurethane (PU), polyethylene, polymethyl acrylate (PMA), polybutyl acrylate (PBA), and polylactic-co-glycolic acid (PLGA).
Further, in S1, the curing method is uv curing, photo curing, thermal curing, or solvent evaporation curing.
Further, in S1, the liquid immiscible with the polymer prepolymer solution and incapable of polymerization is one of F108, polyvinyl alcohol (PVA), and Sodium Dodecyl Sulfate (SDS).
Further, in S1, when the polymer prepolymer is ethoxylated trimethylolpropane triacrylate (ETPTA), the curing mode is uv curing; when the polymer precursor is polymethyl acrylate (PMA) or polybutyl acrylate (PBA), the curing mode is photocuring or thermocuring; when the polymer prepolymer is Polyurethane (PU), polyethylene or polylactic-co-glycolic acid (PLGA), the curing mode is solvent volatilization curing.
Further, the inner hole structures of the conduits prepared in the step S2 are communicated with each other, so that a certain amount of lubricating liquid can be stored.
Further, in S3, the lubricant is one of perfluoropolyether, paraffin, fluorosilicone oil, mineral oil, and ionic liquid.
The invention also provides a lubricating oil-infused ultra-smooth porous surface for a medical catheter, which is prepared according to the preparation method.
The invention has the beneficial effects that:
(1) the super-smooth porous surface infused with the lubricating liquid provided by the invention has good stability, can reduce the adhesion of water molecules and biomolecules in the use process, prevent the formation of thrombus, bacterial film and the like, prolong the service life of the medical catheter and reduce the risk of infection in the use process;
(2) the medical catheter is prepared by adopting a rapid stirring method, is simple, convenient and rapid to operate, has low cost, is suitable for mass production, and greatly expands the practical value of the infiltrating material;
(3) the super-smooth porous surface filled with the lubricating liquid provided by the invention is suitable for various medical instruments such as scalpels and cardiac pacemakers, and shows good applicability and market value.
Drawings
FIG. 1 is a schematic view of a lubricant-infused ultra-smooth porous surface for medical catheters and a process for preparing the same according to the present invention; wherein, the diagram A is a schematic diagram of a polymer prepolymer solution dispersed with a large number of liquid drops obtained by a rapid stirring method, and the diagram B is a schematic diagram of a polymer prepolymer solution poured into a catheter mould and polymerized; FIG. C is a schematic view of a porous catheter obtained by washing away unpolymerized solution;
FIG. 2 is a schematic diagram showing a sliding process of 10. mu.l water drops on the ultra-smooth porous surface prepared in example 3 of the present invention.
The specific implementation mode is as follows:
in order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention and the accompanying drawings, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention. The conditions not specified in the examples are generally those in routine experiments.
A method of preparing a lubricant infused ultra-smooth porous surface for a medical catheter comprising the steps of:
s1, taking a polymer precursor, preparing a polymer precursor solution, adding a liquid (F108, polyvinyl alcohol or sodium dodecyl sulfate) which is immiscible with the polymer precursor solution and can not be polymerized into the polymer precursor solution, and rapidly stirring to form a precursor solution dispersed with a large number of liquid drops, as shown in figure 1A; the polymer prepolymer is one of ethoxylated trimethylolpropane triacrylate (ETPTA), Polyurethane (PU), polyethylene, polymethyl acrylate (PMA), polybutyl acrylate (PBA) and polylactic-co-glycolic acid (PLGA); the curing mode is ultraviolet curing, photocuring, thermocuring or solvent volatilization curing;
specifically, when the polymer prepolymer adopts ethoxylated trimethylolpropane triacrylate (ETPTA), the curing mode is ultraviolet curing; when the polymer precursor is polymethyl acrylate (PMA) or polybutyl acrylate (PBA), the curing mode is photocuring or thermocuring; when the polymer prepolymer is Polyurethane (PU), polyethylene or polylactic-co-glycolic acid (PLGA), the curing mode is solvent volatilization curing.
S2, pouring the solution prepared in the S1 into a catheter mould, solidifying the solution, as shown in figure 1B, and then washing off unpolymerized liquid drops by water and alcohol fully to obtain a catheter with a hole structure, as shown in figure 1C; the hole structures in the guide pipe are communicated with each other, and a certain amount of lubricating liquid can be stored.
S3, infiltrating a layer of chemically inert lubricating oil into the inside and the surface of the catheter hole prepared in the step S2 to obtain a super-smooth porous surface for lubricating oil perfusion of the medical catheter; the lubricating oil is one of perfluoropolyether, paraffin, fluorosilicone oil, mineral oil and ionic liquid.
Example 1
Preparation of hard lubricant infused ultra-smooth porous catheter:
(1) a solution of ethoxylated trimethylolpropane triacrylate (ETPTA) containing 1% (v/v) photoinitiator (2-hydroxy-2-methylpropiophenone) was prepared in a centrifuge tube, followed by addition of a 2% (w/v) F108 solution, which was rapidly stirred to form a prepolymer solution with a large number of droplets dispersed therein.
(2) And pouring the formed prepolymer solution dispersed with a large number of liquid drops into a catheter mould, polymerizing by using 365 nm-waveband ultraviolet light, and then fully washing off the unpolymerized liquid drops by using water and alcohol to obtain the pipeline with the hole structure.
(3) And soaking the prepared pipeline in a fluorosilicone oil solution to soak a layer of fluorosilicone oil in the hole and on the surface of the hole to obtain the super-smooth surface for the lubricating oil perfusion of the medical catheter.
Example 2
Preparing a flexible lubricating oil-filled ultra-smooth porous catheter:
(1) a20% (w/v) Polyurethane (PU) solution was prepared in a centrifuge tube, followed by addition of a liquid paraffin solution and rapid stirring of the solution to form a prepolymer solution in which a large number of droplets were dispersed.
(2) And pouring the formed prepolymer solution dispersed with a large number of liquid drops into a catheter mould, and putting the catheter mould on a 60 ℃ hot bench for heating to volatilize the solvent so as to obtain the lubricating oil-filled super-smooth surface for the medical catheter.
Example 3
Wettability testing of lubricating oil-impregnated ultra-smooth porous catheters:
(1) a solution of ethoxylated trimethylolpropane triacrylate (ETPTA) containing 1% (v/v) photoinitiator (2-hydroxy-2-methylpropiophenone) was prepared in a centrifuge tube, followed by addition of a solution containing 2% (w/v) F108, and the solution was rapidly stirred to form a prepolymer solution with a large number of droplets dispersed therein.
(2) Pouring the precursor solution dispersed with a large number of liquid drops into a catheter mould, polymerizing by using 365 nm-waveband ultraviolet light, and then fully washing off the unpolymerized liquid drops by using water and alcohol to obtain the pipeline with the hole structure.
(3) And soaking the prepared pipeline in a fluorosilicone oil solution to soak a layer of fluorosilicone oil in the hole and on the surface of the hole to obtain the super-smooth surface for the lubricating oil perfusion of the medical catheter.
(4) A10. mu.l drop was dropped on the surface of the prepared medical catheter and gently tilted, and the angle at which the drop started to slide (i.e., the sliding angle) was recorded, showing that the sliding angle was less than 5 °, as shown in FIG. 2.
The above is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention, it should be noted that, for those skilled in the art, several modifications and decorations without departing from the principle of the present invention should be regarded as the protection scope of the present invention.
Claims (8)
1. A method of preparing a lubricant infused ultra-smooth porous surface for a medical catheter, comprising the steps of:
s1, taking a polymer precursor, preparing a polymer precursor solution, adding a liquid which is immiscible with the polymer precursor solution and can not be polymerized into the polymer precursor solution, and quickly stirring to form a precursor solution dispersed with a large number of liquid drops;
s2, pouring the solution prepared in the S1 into a catheter mould, solidifying, and then fully washing off unpolymerized liquid drops by water and alcohol to obtain the catheter with a hole structure;
and S3, infiltrating a layer of chemically inert lubricating oil into the inside and the surface of the hole of the catheter prepared in the step S2 to obtain the super-smooth porous surface for lubricating oil perfusion of the medical catheter.
2. The method of claim 1, wherein in S1, the polymer prepolymer is one of ethoxylated trimethylolpropane triacrylate, polyurethane, polyethylene, polymethyl acrylate, polybutyl acrylate, and polylactic acid-glycolic acid copolymer.
3. The method for preparing a lubricant-infused ultra-smooth porous surface for medical catheters as claimed in claim 1, wherein in S2, the curing method is uv curing, thermal curing or solvent evaporation curing.
4. The method of claim 1, wherein the non-polymerizable liquid immiscible with the polymer prepolymer solution in S1 is one of F108, polyvinyl alcohol, and sodium lauryl sulfate.
5. The method for preparing a lubricating oil-infused ultra-smooth porous surface for medical catheters as claimed in claim 1, wherein in S2, when the polymer prepolymer is ethoxylated trimethylolpropane triacrylate, the curing method is uv curing; when the polymer prepolymer is polymethyl acrylate or polybutyl acrylate, the curing mode is ultraviolet curing or thermocuring; when the polymer prepolymer is polyurethane, polyethylene or polylactic acid-glycolic acid copolymer, the curing mode is solvent volatilization curing.
6. The method of claim 1, wherein the holes inside the catheter prepared in step S2 are interconnected to store a certain amount of lubricant.
7. The method of claim 1, wherein in S3, the lubricant is one of perfluoropolyether, paraffin, fluorosilicone oil, mineral oil, and ionic liquid.
8. A super-smooth porous surface for lubricant infusion of medical catheters, prepared according to the method of any one of claims 1 to 7.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011509397.9A CN112472877B (en) | 2020-12-18 | 2020-12-18 | Method for preparing lubricating oil-infused ultra-smooth porous surface for medical catheter |
| PCT/CN2021/135647 WO2022127631A1 (en) | 2020-12-18 | 2021-12-06 | Preparation method for ultra-smooth porous surface for lubricating oil infusion of medical catheter |
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| CN202011509397.9A CN112472877B (en) | 2020-12-18 | 2020-12-18 | Method for preparing lubricating oil-infused ultra-smooth porous surface for medical catheter |
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| CN112472877A CN112472877A (en) | 2021-03-12 |
| CN112472877B true CN112472877B (en) | 2022-03-08 |
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| CN112472877B (en) * | 2020-12-18 | 2022-03-08 | 南京鼓楼医院 | Method for preparing lubricating oil-infused ultra-smooth porous surface for medical catheter |
| CN113616859A (en) * | 2021-07-08 | 2021-11-09 | 深圳先进技术研究院 | Antibacterial lubricating coating and preparation method and application thereof |
| CN113528010A (en) * | 2021-08-27 | 2021-10-22 | 电子科技大学 | Preparation and application of super-smooth coating with long-acting ice-thinning characteristic |
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| WO2022127631A1 (en) | 2022-06-23 |
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