WO2022109088A1 - Procédé de fabrication de lotion désinfectante pouvant être utilisée comme hydratant, démaquillant et pour d'autres utilisations - Google Patents

Procédé de fabrication de lotion désinfectante pouvant être utilisée comme hydratant, démaquillant et pour d'autres utilisations Download PDF

Info

Publication number
WO2022109088A1
WO2022109088A1 PCT/US2021/059825 US2021059825W WO2022109088A1 WO 2022109088 A1 WO2022109088 A1 WO 2022109088A1 US 2021059825 W US2021059825 W US 2021059825W WO 2022109088 A1 WO2022109088 A1 WO 2022109088A1
Authority
WO
WIPO (PCT)
Prior art keywords
emulsion
amount
present
combination
solution
Prior art date
Application number
PCT/US2021/059825
Other languages
English (en)
Inventor
Marta Pazos
Original Assignee
Dr. Mpp, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Mpp, Inc. filed Critical Dr. Mpp, Inc.
Priority to US18/253,226 priority Critical patent/US20230414459A1/en
Publication of WO2022109088A1 publication Critical patent/WO2022109088A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/14—Preparations for removing make-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/064—Water-in-oil emulsions, e.g. Water-in-silicone emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/22—Peroxides; Oxygen; Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/362—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/927—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of insects, e.g. shellac
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin

Definitions

  • Multifunctional skincare products are increasingly popular. They shorten the time required for tasks like makeup removal and moisturizing of the skin, it is less expensive for consumers to purchase a single product as opposed to three or four, and fewer total products used results in an overall reduction of plastic waste.
  • current multifunctional skincare products may not meet all the needs of individuals with various skin types including, but not limited to, makeup removal, skin cleansing, moisturizing, and/or skin conditioning.
  • Makeup tools and other grooming and personal care tools including makeup brushes, makeup blending sponges, nail files, nail clippers, eyebrow combs, eyelash curlers, and the like, should be regularly cleaned. Many consumers do not clean such tools as often as recommended by dermatologists, or do not clean the tools with appropriate cleansing products due to lack of knowledge, lack of time, or for some other reason.
  • Used makeup application tools accumulate skin oils, product residues, dead skin cells, and other debris, providing a rich breeding ground for fungi, Staphylococcus bacteria, and other pathogens, resulting in skin and eye infections, irritation, and acne. Similarly, dirty nail clippers and nail files may transmit fungal infections. Furthermore, clean makeup tools are more likely to provide optimal product application. What is needed is a single product suitable for cleaning a diverse set of makeup application and other personal care tools.
  • a typical emulsion contains two non-miscible liquid phases, for example oil and aqueous phases, with one phase being present in small droplets dispersed throughout the other phase.
  • Some commercial products for example biphasic makeup removers, must be shaken by the consumer immediately prior to use in order to disperse one phase in the other. Inadequate shaking can lead to loss of effectiveness as the proper distribution of phases may not be present.
  • Other emulsions can be stabilized by the inclusion of amphiphilic agents or mechanical stabilizers. However, these products can still separate if stored for an extended period of time or exposed to extreme conditions during transport, warehouse storage, and the like. Furthermore, inclusion of high amounts of alcohol in emulsions may cause the breakdown of stabilizers and/or emulsifiers.
  • antibacterial and antiviral personal care products that are stable and nonirritating, easy to use, and multifunctional, and a process for preparing the same.
  • similar processes and equipment could be used to prepare different types of products such as for use as hand lotions and sanitizers, makeup cleansers and removers, and makeup tool cleansers.
  • the products would be packaged to cater to consumer convenience and to reduce plastic waste.
  • the products are provided in the form of emulsions or solutions that are effective, stable, and non-irritating while retaining anti- pathogenic properties.
  • the disclosure in one aspect, relates to stable emulsions incorporating an oil phase and an alcohol phase, wherein the emulsions contain one or more oxidative compounds, organic acids, and, optionally, skin conditioners, vitamins, fragrances, and the like.
  • the emulsions are, in one aspect, useful as sanitizing lotions, moisturizing skin treatments, and makeup cleansers or removers.
  • the emulsions are effective at sanitizing the skin but are non-drying and non-irritating.
  • single-phase liquid solutions incorporating at least one monoalcohol, a polyalcohol, and one or more oxidative compounds.
  • the solutions are useful as cleansers for makeup and grooming tools.
  • methods of making the emulsions and solutions are also disclosed.
  • emulsions and solutions prepared by the disclosed processes.
  • the emulsions and solutions can, in one aspect, have antimicrobial activity including, but not limited to, antiviral, antibacterial, and antifungal activity.
  • the emulsions include (i) a gel phase containing a bulking agent, water, a first oxidative compound, a monoalcohol, a second oxidative compound, and at least one organic acid, (ii) an oil phase containing one or more of mineral oil, at least one silicone, and beeswax, and (iii) an emulsifier.
  • the emulsions can also include a co-emulsifier as well as numerous optional ingredients disclosed below.
  • the disclosed emulsions include an alcoholic phase in an oil phase, or are A/O emulsions, in that the droplets of the alcohol phase are dispersed in a continuous oil phase.
  • the oil phase is the first phase to contact the skin and may be more compatible with human skin, which is hydrophobic.
  • the oil phase facilitates penetration and/or delivery of the alcohol phase, wherein the alcohol phase is antimicrobial.
  • the antimicrobial alcohol phase can reduce or eliminate populations of viruses, pathogenic bacteria, and fungi on the skin.
  • the oil phase can create a protective film that enables the alcohol phase to act for a prolonged period of time, further protecting the skin against exposure to infection-causing microorganisms.
  • the single phase liquid solutions include water, at least one oxidative compound, at least one monoalcohol, a polyalcohol, and one or more additional components selected from vitamins, organic acids, skin conditioners, and combinations thereof.
  • a process for preparing an emulsion includes admixing (i) a gel phase that includes a bulking agent, water, a first oxidative compound, a monoalcohol, a second oxidative compound, and at least one organic acid with (ii) an oil phase that includes one or more of mineral oil, at least one silicone, and beeswax.
  • the process includes the following steps:
  • the first admixture is agitated for from at least 5 minutes to about 30 minutes, or for about 5, 10, 15, 20, 25, or 30 minutes, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • a co-emulsifier can be admixed with the first admixture after 5 minutes of agitation.
  • the first admixture and the co-emulsifier can be agitated for at least 15 minutes, or for about 15, 20, 25, or about 30 minutes, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the second admixture can be agitated for at least 10 minutes prior to performing step (c).
  • the oil phase can be agitated for from at least 5 minutes to about 30 minutes, or for about 5, 10, 15, 20, 25, or 30 minutes, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the elevated temperature in step (d) is from about 50 °C to about 90 °C, or is about 50, 55, 60, 65, 70, 75, 80, 85, or about 90 °C, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the admixed gel phase and oil phase are agitated for from about 10 minutes to about 30 minutes in step (f), or for about 10, 15, 20, 25, or about 30 minutes, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • a co-emulsifier can be added to the first admixture or the second admixture in step (a) or (b).
  • an inorganic salt can be added to the first admixture or the second admixture in step (a) or (b).
  • the process for preparing an emulsion further includes adding one or more additional components to the oil phase in step (d), wherein the one or more additional components are selected from a natural oil, a skin conditioner, petroleum jelly, an antioxidant, a fragrance, an ingredient that imparts a color to the emulsion, or any combination thereof.
  • the process for preparing an emulsion includes adding an emulsion stabilizer to the blended oil and alcohol phases in step (f).
  • the process includes agitating the first admixture for from at least 5 minutes to about 30 minutes, or for about 5, 10, 15, 20, 25, or about 30 minutes, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the second admixture can be agitated for from at least 5 minutes to about 30 minutes, or for about 5, 10, 15, 20, 25, or about 30 minutes, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the solution can be agitated for from about 10 minutes to about 30 minutes in step (c), or for about 10, 15, 20, 25, or about 30 minutes, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the process for preparing a solution can further include adding an inorganic salt in any of steps (a), (b), and/or (c).
  • one or more additional components can be added to the second admixture in step (c), including, but not limited to, a fragrance, an ingredient that imparts color to the solution, or any combination thereof.
  • the disclosed emulsions can be formulated as a sanitizing hand lotion.
  • many hand sanitizers currently on the market consist of hydrogels containing at least 60% ethyl alcohol or isopropyl alcohol.
  • the amount of alcohol can be at least 70% ethyl alcohol.
  • the disclosed compositions simultaneously provide disinfection capabilities while also providing moisture to the skin.
  • active ingredients in the sanitizing hand lotions can include one or more monoalcohols such as, for example, ethyl alcohol or isopropyl alcohol, and can further include oxidizing compounds such as, for example, hydrogen peroxide, sodium hypochlorite, calcium hypochlorite, and/or citric acid.
  • oxidizing compounds provide a different mechanism of action against bacteria and viruses by destroying bacterial cell walls, viral envelopes, and similar features.
  • the sanitizing hand lotions can be formulated as emulsions containing the active ingredients in the alcohol phase. Exemplary procedures for preparing emulsions can be found in the Examples.
  • the sanitizing hand lotions when formulated as emulsions, further include an oil phase.
  • the oil phase when applied to the hands of a subject, can create a fdm on the skin that prevents active compounds such as monoalcohols or oxidizing compounds from evaporating or detaching from the skin surface, thereby increasing the time period over which the active compounds are effective. Without wishing to be bound by theory, this fdm may also prevent additional pathogens from contacting the skin.
  • the emulsions can be provided pre-applied to, or for use in conjunction with, gloves for a deeper treatment of the hands. Further in this aspect, use of gloves allows for prolonged contact with skin, which may enhance antimicrobial and/or sanitizing effects while also moisturizing and conditioning the skin.
  • the sanitizing hand lotions can be applied to the entire arm without causing dryness, dermatitis, chapping, eczema, or other issues that may be commonly experienced by individuals requiring frequent use of hand sanitizers.
  • the sanitizing hand lotions may be of particular use to medical workers (e.g., doctors, nurses, physicians’ assistants, phlebotomists, imaging technicians, paramedics, and the like) and to first responders such as, for example, police officers and firefighters) who have frequent contact with members of the public and who may encounter viruses, bacteria, and fungi under normal working conditions.
  • the emulsions can be formulated as a foot lotion or as a component of a foot treatment.
  • the emulsions may be useful in preventing or treating infections such as papilloma (warts), athlete’s foot, toenail fungus, bacterial infections including those that may cause abscesses, particular in diabetic individuals, and the like.
  • infections such as papilloma (warts), athlete’s foot, toenail fungus, bacterial infections including those that may cause abscesses, particular in diabetic individuals, and the like.
  • gauze, compresses, adhesive bandages, and the like can be provided pre -impregnated with the emulsions for use on the feet or elsewhere on the body.
  • the emulsions may also be useful for treatment of other areas prone to infection and dryness including, but not limited to, elbows, knees, heels, and ears.
  • the emulsions can be used to treat sores, cracks in the skin, open wounds, and the like. Further in this aspect, the emulsions can soothe areas where skin is disrupted, providing moisture while creating an oil barrier to prevent penetration of pathogens through the skin.
  • the emulsions can be formulated as a makeup cleanser.
  • the compositions may be useful for removal of foundation, concealer, mascara, eyeshadow, eyeliner, blush, lipstick, highlighter, bronzer, or any other product applied to the face for cosmetic purposes.
  • the makeup cleanser formulations contain lower amounts of monoalcohols (e.g. ethyl alcohol and/or isopropyl alcohol) and higher amounts of polyalcohols (e.g. glycerin).
  • monoalcohols e.g. ethyl alcohol and/or isopropyl alcohol
  • polyalcohols e.g. glycerin
  • including lower amounts of monoalcohols results in a formulation that is not harsh on sensitive facial skin and including higher amounts of polyalcohols allows for a balance of cleansing and moisturizing functions in the makeup cleanser formulations.
  • the makeup cleanser formulations may have lower amounts of organic acids such as citric acid and oxidizing compounds such as sodium hypochlorite when compared to the sanitizing hand lotions and makeup tools cleansers disclosed herein.
  • antiviral and antibacterial efficacy may be somewhat lower than for formulations with higher amounts of monoalcohols, organic acids, and/or oxidizing compounds; however, in another aspect, potent antipathogens are not typically required for use on facial skin.
  • compositions formulated as makeup cleansers are prepared as emulsions.
  • Exemplary methods for preparing emulsions are provided in the Examples.
  • the single phase liquid solutions can be formulated as a cleanser for makeup tools and other personal grooming and hygiene items including, but not limited to, makeup brushes, sponges, nail clippers, nail files, eyelash curlers, eyelash and brow combs, tweezers, and the like.
  • the makeup tools cleanser is formulated as a monophase liquid (i.e., solution) containing water, one or more monoalcohols, a small amount of a polyalcohol, and oxidative compounds and/or organic acids such as, for example, citric acid, sodium hypochlorite, calcium hypochlorite, and the like.
  • the makeup tools cleanser can contain pH regulators such as, for example, triethanolamine, or can contain vitamins or other additives as described herein.
  • the packaging system can be a nonreactive bottle made from plastic or glass and could include an optional pumping or spraying dispensers.
  • the packaging system could be a blister package such as, for example, a thermoformed tray containing several sealed receptacles containing a predetermined amount of the compositions.
  • each sealed receptacle can be covered with a foam, wherein the product can diffuse through the foam, and the seal can be a fdm that protects the product and foam and prevents evaporation of the product prior to use.
  • a tool such as an application brush or sponge can be rubbed against a foam soaked with the product.
  • a tool such as a nail clipper, nail fde, eyebrow comb, tweezers, or the like, can be sprayed with the product or fully immersed in the product.
  • compositions for use as makeup tools cleansers can be prepared as solutions.
  • Exemplary methods for preparing solutions are provided in the Examples.
  • compositions formulated as emulsions include a bulking agent.
  • a bulking agent can be useful for controlling the consistency, stability, and viscosity of the compositions.
  • addition of a bulking agent to the compositions can stabilize the alcohol phase of the compositions. Further in this aspect, when the amount of bulking agent is too low, alcohol can diffuse through the compositions and cause instability, ultimately causing the breakdown of the compositions. In another aspect, when the amount of bulking agent is too high, use of the compositions causes residue to be left behind, which may be undesirable to consumers.
  • viscosity can be controlled by the number and relative amount of bulking agents as well as by the consistency and/or phase at room temperature of the raw materials used to make the compositions.
  • the single phase liquid solutions also include a bulking agent.
  • the bulking agent in any of the disclosed formulations can be hydroxypropyl methyl cellulose.
  • the hydroxypropyl methyl cellulose can have an average molecular weight of about 4000 Da.
  • the emulsions include from about 3.5 wt% to about 10 wt% of the bulking agent, or about 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, or about 10 wt% of the bulking agent, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the bulking agent is not carbomer, polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVOH), or another cellulose derivative not already listed. Without wishing to be bound by theory, these components may not produce a stable emulsion.
  • the bulking agent is not ethyl cellulose, propyl cellulose, or microcrystalline cellulose.
  • these cellulose derivatives are not soluble in the monoalcohol and water of the alcohol phase of the emulsions.
  • the compositions can include a fdler or co-emulsifier in addition to a bulking agent.
  • the fdler can be a clay such as, for example, bentonite.
  • fdlers can be useful for adjusting composition consistency or viscosity in either emulsions or solutions.
  • the fdler when the compositions are formulated as emulsions, the fdler can act as a co-emulsifier.
  • the fdler or co-emulsifier can be present in an amount of from about 0 to about 2 wt% of the compositions, or from about 0.01 to about 2 wt% of the compositions, or at about 0, 0.01, 0.1, 0.25, 0.5, 0.75, 1, 1.25, 1.5, 1.75, or about 2 wt% of the compositions, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the fdler or co-emulsifier can absorb some moisture from the compositions, increasing antibacterial and antifungal activity, since microorganisms require water to survive.
  • the disclosed compositions can include an inorganic salt.
  • the inorganic salt can be added to the first admixture in step (a) or the second admixture in step (b) according to the process for making an emulsion.
  • the inorganic salt can be sodium chloride.
  • the inorganic salt is present in an amount of from about 0 to about 2 wt% of the emulsion, or from about 0.01 to about 2 wt% of the emulsion, or from about 0.5 to about 2 wt% of the emulsion, or about 0, 0.01, 0.1, 0.25, 0.5, 0.75, 1, 1.25, 1.5, 1.75, or about 2 wt% of the emulsion, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the inorganic salt can act as a bulking agent for the compositions and/or may provide additional antibacterial properties.
  • the single -phase liquid solutions can include an inorganic salt such as, for example, sodium chloride.
  • the inorganic salt can be present in an amount of from about 0.5 to about 2 wt% of the solutions, or about 0.5, 0.75, 1, 1.25, 1.5, 1.75, or about 2 wt% of the solutions, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the compositions can include one or more oxidative compounds such as, for example, hydrogen peroxide, calcium hypochlorite and/or sodium hypochlorite, and organic acids including, but not limited to, citric acid.
  • oxidative compounds such as, for example, hydrogen peroxide, calcium hypochlorite and/or sodium hypochlorite, and organic acids including, but not limited to, citric acid.
  • inclusion of oxidative compounds can increase the efficacy of the compounds against bacteria, viruses, and other pathogens, even if a lower amount of alcohol is used in the compositions than the 70% recommended by the US Centers for Disease Control and Prevention (CDC) or World Health Organization (WHO).
  • the oxidative compound can attack and/or cause damage to the cell walls of bacteria and/or to virus capsids and the envelopes of enveloped viruses.
  • the first oxidative compound in the methods and emulsions disclosed herein, can be sodium hypochlorite, calcium hypochlorite, or any combination thereof. In a further aspect, the first oxidative compound can be present in an amount of from about 0.1 to about 0.3 wt% of the emulsion, or can be about 0.1, 0. 15, 0.2, 0.25, or about 0.3 wt% of the emulsion, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values. In one aspect, when the first oxidative compound is sodium hypochlorite or calcium hypochlorite, it can be provided as a solid material or powder having up to about 75% concentration of sodium hypochlorite or calcium hypochlorite.
  • the second oxidative compound can be hydrogen peroxide, benzoyl peroxide, benzyl alkylammonium chloride, or any combination thereof.
  • the second oxidative compound is a 3 wt% solution of hydrogen peroxide in water.
  • the second oxidative compound is present in an amount of from about 0 to about 1 wt% of the emulsion, or from about 0.01 to about 1 wt% of the emulsion, or from about 0.03 to about 1 wt% of the emulsion, or about 0, 0.01, 0.03, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, or about 1 wt% of the emulsion, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the oxidative compound in the single phase liquid solutions disclosed herein, can be sodium hypochlorite, calcium hypochlorite, hydrogen peroxide, benzoyl peroxide, benzyl alkylammonium chloride, or any combination thereof. Further in this aspect, the oxidative compound can be present in an amount of from about 0.13 to about 6 wt% of the solution, or about 0.13, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, or about 6 wt% of the solution, of a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the compositions can include at least one monoalcohol such as, for example, ethyl alcohol, isopropyl alcohol, or any combination thereof.
  • the monoalcohol can be present in an amount of up to 70 wt% of the compositions.
  • including up to 70 wt% of the monoalcohol can be useful for imparting antimicrobial properties to the formulations.
  • including at least 60 wt% and up to 70 wt% of the monoalcohol or alcohol phase of the compositions satisfies US Centers for Disease Control and Prevention (CDC) requirements for effective antimicrobial properties for an alcohol-based hand sanitizer.
  • CDC US Centers for Disease Control and Prevention
  • the monoalcohol can be about 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, or about 70 wt% of the emulsions or of the solutions, or a combination of any of the foregoing values, or a range encompassing the foregoing values.
  • the monoalcohol can include a combination of ethyl alcohol and isopropyl alcohol, wherein isopropyl alcohol is no more than 20 wt% of the combination.
  • amounts of ethanol exceeding 90% may disrupt the disclosed emulsions, rendering them unsatisfactory.
  • ethyl alcohol may act as a solvent for the bulking agent.
  • hydroxypropyl methyl cellulose is less soluble in isopropyl alcohol than in ethyl alcohol; thus, in one aspect, when isopropyl alcohol is used in the disclosed emulsions, it may be present as a blend in order to avoid solid residue left on the skin after application of the emulsions.
  • including 70 wt% alcohol phase in the disclosed emulsions allows for the inclusion of enough water to successfully incorporate the bulking agent into the emulsions.
  • the amount of water included in the compositions is dependent upon the amount of bulking agent used in the compositions.
  • the emulsions include from about 4.5 to about 6 wt% water, or about 4.5, 5, 5.5, or about 6 wt% water, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the compositions still include greater than or equal to 60 wt% alcohol as required for effective hand sanitization or other object or surface sanitization.
  • the disclosed single phase solutions also include water.
  • the amount of water in the single phase solutions can range from about 5 to about 35 wt%, or can be about 5, 10, 15, 20, 25, 30, or about 35 wt%, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • water can be useful as a solvent to dissolve solid components introduced into the alcohol phase of the emulsions disclosed herein such as, for example, the bulking agent.
  • the oil phase of the disclosed emulsions can contain mineral oil, silicone, beeswax, or another synthetic or non-organic oil.
  • the mineral oil can be a cosmetic grade or food grade mineral oil that refined and purified and is free from comedogenic substances and irritants.
  • the mineral oil is present in an amount of from about 0 to about 10 wt% of the emulsion, or from about 0.01 to about 10 wt% of the emulsion, or from about 0.5 to about 10 wt% of the emulsion, or about 0, 0.01, 0.1, 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, or about 10 wt% of the emulsion, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the silicone can be a dimethicone, a cyclopentasiloxane, another silicone, or any combination thereof.
  • the silicone can include a range of molecular weights that can be adjusted as needed to form an emulsion having the desired properties such as, for example, viscosity, stability, or the like.
  • the dimethicone when the silicone is a combination of dimethicone and cyclopentasiloxane, is present in an amount of from about 50 to about 99.99 wt% of the combination, or at about 50, 55, 60, 65, 70, 76, 80, 85, 90, 95, or about 99.99 wt%, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the silicone is present in an amount of from about 0 to about 10 wt% of the emulsion, or from about 0.01 to about 10 wt% of the emulsion, or from about 0.5 to about 10 wt% of the emulsion, or about 0, 0.01, 0.1, 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, or about 10 wt% ofthe emulsion, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the compositions can include beeswax as part of the oil phase.
  • the beeswax can be present in an amount of from about 0 to about 10 wt% of the emulsion, or from about 0.01 to about 10 wt% of the emulsion, or from about 0.5 to about 10 wt% of the emulsion, or about 0, 0.01, 0.1, 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, or about 10 wt% of the emulsion, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the compositions can include a natural oil such as, for example, sea buckthorn oil.
  • a natural oil such as, for example, sea buckthorn oil.
  • inclusion of sea buckthorn oil can prevent chafing, which is a common and undesired side effect of applying alcohol on the skin.
  • sea buckthorn oil can reduce inflammation and contribute to repair of the skin barrier due to the presence of omega-3, -6, and -9 fatty acids.
  • sea buckthorn oil can be a source of minerals, vitamins, and other antioxidants, thereby imparting additional skincare benefits.
  • sea buckthorn oil may be useful in protecting against skin dryness caused by wind, sunbum, and other dry conditions.
  • compositions can include one or more other natural oils including, but not limited to, olive oil, hemp oil, coconut oil, or any combination thereof.
  • olive oil can be a source of vitamins A, D, E, and K.
  • olive oil has antioxidant properties and can act as a moisturizer or skin conditioner.
  • hemp oil (sometimes also known as hempseed oil) can have moisturizing ingredients.
  • hemp oil contains omega-6 fatty acids including gamma-linolenic acid, which may have anti-inflammatory effects when applied to the skin.
  • coconut oil includes medium-chain fatty acids such as, for example, lauric acid and capric acid, that have antimicrobial properties.
  • coconut oil may have anti-inflammatory properties and can be moisturizing to the skin.
  • coconut oil may be useful for helping to maintain the skin’s barrier function.
  • use of olive oil, hemp oil, and/or coconut oil can be incorporated into the formulation.
  • the natural oil is present in an amount of from about 0 to about 10 wt% of the emulsion, or from about 0.01 to about 10 wt% of the emulsion, or about 0, 0.01, 0.1, 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, or about 10 wt% of the emulsion, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the emulsifier can be cetyl diglyceryl tris(trimethylsiloxy)silylethyl dimethicone or another emulsifier. Further in this aspect, and without wishing to be bound by theory, the emulsifier is added to the oil phase and can stabilize the emulsion between an alcohol and an oil phase, wherein the emulsion has an oil as the outer phase.
  • the emulsifier can be present in an amount of from about 0 to about 5 wt% of the emulsion, or about 0.01 to about 5 wt% of the emulsion, or from about 0.2 to about 3 wt% of the emulsion, oratabout O, 0.01, 0.1, 0.2, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, or about 5 wt% of the emulsion, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the compositions when the compositions are formulated as solutions rather than as emulsions, can include a polyalcohol such as, for example, glycerin.
  • glycerin can improve the skin’s barrier function, hydrate the skin, accelerate wound healing, protect against irritants, or any combination thereof.
  • glycerin can be included in emulsion formulations. In any of these aspects, the glycerin can be useful for altering or adjusting the viscosity of the compositions.
  • glycerin or another polyalcohol to a solution formulation or inclusion of a greater amount of glycerin to the solution can impart body and/or viscosity to the solution (i.e. make it feel less watery).
  • glycerin may be useful as a humectant and/or may assist penetration of the skin by the other components of the compositions and/or may aid in stabilizing the emulsions.
  • the polyalcohol can be glycerin, butylene glycol, polyethylene glycol (PEG), or any combination thereof.
  • the polyalcohol can be present in an amount of from about 3 wt% to about 10 wt% of the solution, or at about 3, 4, 5, 6, 7, 8, 9, or about 10 wt% of the solution, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the petroleum jelly can aid in retaining moisture in the skin and in preventing the monoalcohol in the formulations from cracking or drying the skin.
  • the petroleum jelly is present in an amount of from about 0 to about 10 wt% of the emulsion, or from about 0.01 to about 10 wt% of the emulsion, or about 0, 0.01, 0.1, 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, or about 10 wt% of the emulsion, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the compositions can include one or more skin conditioners.
  • the skin conditioner can be or include glycerin, polyethylene glycol (PEG), butylene glycol, polysorbate, a PEG-based surfactant, a PEG-based emulsifier, or any combination thereof.
  • the skin conditioner can be present in an amount of from about 3 wt% to about 10 wt% of the compositions, or at about 3, 4, 5, 6, 7, 8, 9, or about 10 wt% of the compositions, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the compositions can include one or more organic acids such as, for example, an alpha hydroxy acid.
  • the organic acids can include citric acid, lactic acid, malic acid, glycolic acid, hyaluronic acid, a salt thereof, or any combination thereof.
  • the organic acid may be useful for gently exfoliating the skin and/or for maintaining a favorable balance among skin microbiota species.
  • the organic acid can provide non-mechanical exfoliation as well as skin brightening and/or spot correction properties.
  • the salts of organic acids such as, for example, calcium citrate can be used to balance or correct the pH of the compositions to render them suitable for application on the skin.
  • the at least one organic acid is present in an amount of from about 0% to about 2 wt% of the emulsion, or from about 0.01 to about 2 wt% of the emulsion, or from about 0.5 to about 2 wt% ofthe emulsion, or about 0, 0.01, 0.1, 0.25, 0.5, 0.75, 1, 1.25, 1.5, 1.75, or about 2 wt% of the emulsion, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the at least one organic acid or salt thereof is present in an amount of from about 0.51 to about 2 wt% of the single phase liquid solutions, or about 0.51, 0.75, 1, 1.25, 1.5, 1.75, or about 2 wt% of the single phase liquid solutions, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • compositions can include one or more vitamins such as, for example, ascorbic acid (vitamin C), biotin (vitamin B7), pantothenic acid (vitamin B6), retinol (vitamin A), tocopherol (vitamin E), a derivative thereof, or any combination thereof.
  • vitamin C can provide benefits to the skin due to its antioxidant and anti -aging properties.
  • vitamin C may assist in the production of collagen and/or elastin and may reduce the appearance of hyperpigmentation, among other benefits.
  • the vitamins may act as preservatives.
  • the one or more vitamins are present in an amount of from about 0 to about 3 wt% of the emulsion, or from about 0.01 to about 3 wt% of the emulsion, or from about 0.7 to about 3 wt% of the emulsion, or about 0, 0.01, 0.1, 0.5, 0.7, 1, 1.5, 2, 2.5, or about 3 wt% ofthe emulsion, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the one or more vitamins are present in an amount of from about 0.5 to about 1 wt% of the single phase liquid solutions, or at about 0.5, 0.6, 0.7, 0.8, 0.9, or about 1 wt% of the single phase liquid solutions, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the compositions can include a fragrance.
  • the fragrance can be a fruit fragrance, a floral fragrance, an herbal or spice fragrance, a beverage fragrance, or any combination thereof.
  • the fragrance can be a lemon verbena fragrance, a tea and cherry blossom fragrance, or another fragrance.
  • the compositions do not include a fragrance.
  • fragrance-free compositions may be especially suited for individuals with allergies or sensitivities to fragrance, or for people in the medical field or in manufacturing jobs who are not allowed to wear perfumes while working.
  • the fragrance can be provided as an essential oil.
  • essential oils are soluble in both phases of an alcohol/oil emulsion, whereas in the typical water/oil emulsions found in existing products, essential oils are only soluble in the oil phase.
  • monoalcohols facilitate penetration of the external layers of the skin by opening pores. Further in this aspect, with the alcohol phase penetrating the skin and the oil phase forming a film on the skin, and with the fragrance being soluble in both phases, the scent of the emulsions can last longer on the skin.
  • the single phase liquid solutions disclosed herein can include from about 0 to about 0.1 wt%, or from about 0.01 to about 1 wt%, or about 0.01, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, or about 1 wt% of the solutions, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the fragrance can include lemon, bergamot, lemon verbena, orange, lavender, white tea, green tea, sage, rosemary, frankincense, another fruit fragrance, herbal fragrance, spice fragrance, or beverage fragrance, or any combination thereof.
  • the compositions can include at least one antioxidant.
  • the antioxidant can be butylated hydroxytoluene (BHT).
  • BHT butylated hydroxytoluene
  • the antioxidant is present in an amount of from about 0 to about 5 wt% of the emulsion, or about 0.01 to about 5 wt% of the emulsion, or from about 0.1 to about 5 wt% of the emulsion, or at about 0, 0.01, 0.1, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, or about 5 wt% of the emulsion, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the antioxidant can prevent oil ingredients from oxidizing due to free radical exposure.
  • the optional emulsion stabilizer can be a sodium acrylate/sodium acryloyldimethyl taurate copolymer, isohexadecane, polysorbate 80, or any combination thereof.
  • the emulsion stabilizer is present in an amount of from about 0 to about 5 wt% of the emulsion, or about 0.01 to about 5 wt% of the emulsion, or at about 0, 0.01, 0.1, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, or about 5 wt% of the emulsion, or a combination of any of the foregoing values, or a range encompassing any of the foregoing values.
  • the emulsion stabilizer can assist in homogenization of the emulsions and in the prevention of clumping.
  • the compositions can include at least one ingredient that imparts a color.
  • the ingredient that imparts a color can be a natural dye (e.g. from vegetables such as carrots, spinach, beets, and the like), an artificial dye, or any combination thereof.
  • the compositions can be colorless and/or dye-free.
  • ratios, concentrations, amounts, and other numerical data can be expressed herein in a range format. It will be further understood that the endpoints of each of the ranges are significant both in relation to the other endpoint, and independently of the other endpoint. It is also understood that there are a number of values disclosed herein, and that each value is also herein disclosed as “about” that particular value in addition to the value itself. For example, if the value “10” is disclosed, then “about 10” is also disclosed. Ranges can be expressed herein as from “about” one particular value, and/or to “about” another particular value. Similarly, when values are expressed as approximations, by use of the antecedent “about,” it will be understood that the particular value forms a further aspect. For example, if the value “about 10” is disclosed, then “10” is also disclosed.
  • a further aspect includes from the one particular value and/or to the other particular value.
  • ranges excluding either or both of those included limits are also included in the disclosure, e.g. the phrase “x to y” includes the range from ‘x’ to ‘y’ as well as the range greater than ‘x’ and less than ‘y’.
  • the range can also be expressed as an upper limit, e.g. ‘about x, y, z, or less’ and should be interpreted to include the specific ranges of ‘about x’, ‘about y’, and ‘about z’ as well as the ranges of ‘less than x’, less than y’, and ‘less than z’.
  • the phrase ‘about x, y, z, or greater’ should be interpreted to include the specific ranges of ‘about x’, ‘about y’, and ‘about z’ as well as the ranges of ‘greater than x’, greater than y’, and ‘greater than z’.
  • the phrase “about ‘x’ to ‘y’”, where ‘x’ and ‘y’ are numerical values, includes “about ‘x’ to about ‘y’”.
  • 1% to 5% should be interpreted to include not only the explicitly recited values of about 0.1% to about 5%, but also include individual values (e.g., about 1%, about 2%, about 3%, and about 4%) and the sub-ranges (e.g., about 0.5% to about 1.1%; about 5% to about 2.4%; about 0.5% to about 3.2%, and about 0.5% to about 4.4%, and other possible sub-ranges) within the indicated range.
  • the terms “about,” “approximate,” “at or about,” and “substantially” mean that the amount or value in question can be the exact value or a value that provides equivalent results or effects as recited in the claims or taught herein. That is, it is understood that amounts, sizes, formulations, parameters, and other quantities and characteristics are not and need not be exact, but may be approximate and/or larger or smaller, as desired, reflecting tolerances, conversion factors, rounding off, measurement error and the like, and other factors known to those of skill in the art such that equivalent results or effects are obtained. In some circumstances, the value that provides equivalent results or effects cannot be reasonably determined.
  • an “effective amount” refers to an amount that is sufficient to achieve the desired modification of a physical property of the composition or material.
  • an “effective amount” of a monoalcohol refers to an amount that is sufficient to achieve the desired improvement in the property modulated by the formulation component, e.g. achieving the desired level of antibacterial and/or antiviral control without destabilizing an emulsion formed therefrom.
  • the specific level in terms of wt% in a composition required as an effective amount will depend upon a variety of factors including the amount and type of monoalcohol, amount and type of other ingredients, amount and type of oxidative compound, and end use of the composition made using the monoalcohol.
  • An “emulsion” as used herein is a composition containing at least two liquids, wherein a first liquid occurs as small droplets dispersed throughout the second liquid.
  • An emulsion can be formed by mechanical means including, but not limited to, agitation.
  • an emulsion can be stabilized by the incorporation of an amphiphilic agent or by imparting mechanical stability through the use of a filler such as, for example, a clay, silica, or a combination thereof, wherein the filler can be added to either liquid in the emulsion.
  • a typical emulsion can have an aqueous phase and an oil phase.
  • the two liquid phases of the emulsions include a phase primarily composed of a monoalcohol and an oil phase.
  • monoalcohols are typically good solvents for oils and fats; thus, without wishing to be bound by theory, mechanical stabilization of the disclosed emulsions may be particularly important in order to avoid inactivation or destruction of any stabilizing agents or emulsifiers.
  • pressures referred to herein are based on atmospheric pressure (i.e. one atmosphere).
  • a process for preparing an emulsion comprising admixing (i) a gel phase comprising a bulking agent, water, a first oxidative compound, a monoalcohol, a second oxidative compound, and at least one organic acid with (ii) an oil phase comprising one or more of mineral oil, at least one silicone, and beeswax.
  • Aspect 2 The process of aspect 1, the process comprising:
  • Aspect 3 The process of aspect 2, further comprising agitating the first admixture for from at least 5 minutes to about 30 minutes.
  • Aspect 4 The process of aspect 3, further comprising admixing a co-emulsifier with the first admixture after 5 minutes of agitation.
  • Aspect 5 The process of aspect 4, wherein the first admixture and the co-emulsifier are agitated for at least 15 minutes.
  • Aspect 6 The process of any one of aspects 2-5, further comprising agitating the second admixture for at least 10 minutes prior to performing step (c).
  • Aspect 7 The process of any one of aspects 2-6, further comprising agitating the oil phase for from at least 5 minutes to about 30 minutes.
  • Aspect 8 The process of any one of aspects 2-7, wherein the elevated temperature in step (d) is from about 50 to about 90 °C.
  • Aspect 9 The process of any one of aspects 2-8, further comprising agitating the admixed gel phase and oil phase for from about 10 minutes to about 30 minutes in step (f).
  • Aspect 10 The process of any one of the preceding aspects, wherein the bulking agent is hydroxypropyl methyl cellulose.
  • Aspect 11 The process of aspect 10, wherein the hydroxypropyl methyl cellulose has an average molecular weight of about 4000 Da.
  • Aspect 12 The process of aspect 10 or 11, wherein the hydroxypropyl methyl cellulose is present in an amount of from about 3.5 wt% to about 10 wt% of the emulsion.
  • Aspect 13 The process of any one of the preceding aspects, wherein the water is present in an amount of from about 4.5 wt% to about 6 wt% of the emulsion.
  • Aspect 14 The process of any one of the preceding aspects, wherein the first oxidative compound comprises sodium hypochlorite, calcium hypochlorite, or any combination thereof.
  • Aspect 15 The process of any one of the preceding aspects, wherein the first oxidative compound is present in an amount of from about 0. 1 to about 0.3 wt% of the emulsion.
  • Aspect 16 The process of any one of the preceding aspects, wherein the monoalcohol comprises ethyl alcohol, isopropyl alcohol, or any combination thereof.
  • Aspect 17 The process of aspect 16, wherein the monoalcohol comprises a combination of ethyl alcohol and isopropyl alcohol, and wherein isopropyl alcohol comprises no more than 20 wt% of the monoalcohol.
  • Aspect 18 The process of any one of the preceding aspects, wherein the monoalcohol is present in an amount of from about 60 wt% to about 70 wt% of the emulsion.
  • Aspect 19 The process of any one of the preceding aspects, wherein the second oxidative compound comprises hydrogen peroxide, benzoyl peroxide, benzyl alkylammonium chloride, or any combination thereof.
  • Aspect 20 The process of aspect 19, wherein the second oxidative compound is a 3% (w/w) solution of hydrogen peroxide in water.
  • Aspect 21 The process of any one of the preceding aspects, wherein the second oxidative compound is present in an amount of from about 0.03 to about 1 wt% of the emulsion.
  • Aspect 22 The process of any one of the preceding aspects, wherein the at least one organic acid comprises citric acid, lactic acid, malic acid, glycolic acid, hyaluronic acid, a salt thereof, or any combination thereof.
  • Aspect 23 The process of any one of the preceding aspects, wherein the at least one organic acid is present in an amount of from about 0.5 to about 2 wt% of the emulsion.
  • Aspect 24 The process of any one of aspects 2-23, further comprising adding one or more vitamins to the second admixture in step (b).
  • Aspect 25 The process of aspect 24, wherein the one or more vitamins comprise ascorbic acid (vitamin C), biotin (vitamin B7), pantothenic acid (vitamin B6), retinol (vitamin A), tocopherol (vitamin E), derivatives thereof, and any combination thereof.
  • vitamins comprise ascorbic acid (vitamin C), biotin (vitamin B7), pantothenic acid (vitamin B6), retinol (vitamin A), tocopherol (vitamin E), derivatives thereof, and any combination thereof.
  • Aspect 26 The process of aspect 24 or 25, wherein the one or more vitamins are present in an amount of from about 0.7 to about 3 wt% of the emulsion.
  • Aspect 27 The process of any one of aspects 4-26, wherein the co-emulsifier comprises bentonite.
  • Aspect 28 The process of aspect 26 or 27, wherein the co-emulsifier is present in an amount of from about 0.01 to about 2 wt% of the emulsion.
  • Aspect 29 The process of any one of the preceding aspects, further comprising adding an inorganic salt to the first admixture in step (a) or the second admixture in step (b).
  • Aspect 30 The process of aspect 29, wherein the inorganic salt comprises sodium chloride.
  • Aspect 31 The process of aspect 29 or 30, wherein the inorganic salt is present in an amount of from about 0.01 to about 2 wt% of the emulsion.
  • Aspect 32 The process of any one of the preceding aspects, wherein the mineral oil is present in an amount of from about 0.5 to about 10 wt% of the emulsion.
  • Aspect 33 The process of any one of the preceding aspects, wherein the silicone comprises dimethicone or a combination of dimethicone and cyclopentasiloxane.
  • Aspect 34 The process of aspect 33, wherein the silicone comprises a combination of dimethicone and cyclopentasiloxane, and wherein the dimethicone is present in an amount of from 50 to 99.99 wt% in the combination.
  • Aspect 35 The process of any one of the preceding aspects, wherein the silicone is present in an amount of from about 0.5 to about 10 wt% of the emulsion.
  • Aspect 36 The process of any one of the preceding aspects, wherein the beeswax is present in an amount of from about 0.5 to about 10 wt% of the emulsion.
  • Aspect 37 The process of any one of the preceding aspects, wherein the emulsifier comprises cetyl diglyceryl tris(trimethylsiloxy)silylethyl dimethicone.
  • Aspect 38 The process of aspect 36 or 37, wherein the emulsifier is present in an amount of from about 0.2 to about 3 wt% of the emulsion.
  • Aspect 39 The process of any one of aspects 2-38, further comprising adding one or more additional components to the oil phase in step (d), wherein the one or more additional components comprise a natural oil, a skin conditioner, petroleum jelly, an antioxidant, a fragrance, an ingredient that imparts a color to the emulsion, or any combination thereof.
  • the one or more additional components comprise a natural oil, a skin conditioner, petroleum jelly, an antioxidant, a fragrance, an ingredient that imparts a color to the emulsion, or any combination thereof.
  • Aspect 40 The process of aspect 39, wherein the natural oil comprises sea buckthorn oil, olive oil, hemp oil, coconut oil, or any combination thereof.
  • Aspect 41 The process of aspect 39 or 40, wherein the natural oil is present in an amount of from about 0.01 to about 10 wt% of the emulsion.
  • Aspect 42 The process of aspect 39, wherein the skin conditioner comprises glycerin, polyethylene glycol (PEG), butylene glycol, polysorbate, a PEG-based surfactant, a PEG-based emulsifier, or any combination thereof.
  • the skin conditioner comprises glycerin, polyethylene glycol (PEG), butylene glycol, polysorbate, a PEG-based surfactant, a PEG-based emulsifier, or any combination thereof.
  • Aspect 43 The process of aspect 39 or 42, wherein the skin conditioner is present in an amount of from about 3 wt% to about 10 wt% of the emulsion.
  • Aspect 44 The process of aspect 39, wherein the fragrance comprises lemon, bergamot, lemon verbena, orange, lavender, white tea, green tea, sage, rosemary, frankincense, another fruit fragrance, a floral fragrance, an herbal fragrance, a spice fragrance, a fragrance derived from a beverage, or any combination thereof.
  • Aspect 45 The process of aspect 39, wherein the ingredient that imparts a color comprises a natural dye, an artificial dye, or any combination thereof.
  • Aspect 46 The process of any one of aspects 39-45, wherein the petroleum jelly is present in an amount of from about 0.01 to about 10 wt% of the emulsion.
  • Aspect 47 The process of aspect 39, wherein the antioxidant comprises butylated hydroxytoluene (BHT).
  • BHT butylated hydroxytoluene
  • Aspect 48 The process of aspect 39 or 47, wherein the antioxidant is present in an amount of from about 0. 1 to about 5 wt% of the emulsion.
  • Aspect 49 The process of any one of the preceding aspects, further comprising adding an emulsion stabilizer to the emulsion in step (f).
  • Aspect 50 The process of aspect 49, wherein the emulsion stabilizer comprises a sodium acrylate/sodium acryloyldimethyl taurate copolymer, isohexadecane, polysorbate 80, or any combination thereof.
  • Aspect 51 The process of aspect 49 or 50, wherein the emulsion stabilizer is present in an amount of from about 0.01 to about 5 wt% of the emulsion.
  • Aspect 52 An emulsion produced by the process of any one of aspects 1-51.
  • a sanitizing lotion comprising the emulsion of aspect 52.
  • a makeup cleanser comprising the emulsion of aspect 52.
  • a process for preparing a single phase liquid solution comprising:
  • Aspect 56 The process of aspect 55, further comprising agitating the first admixture for from at least 5 minutes to about 30 minutes.
  • Aspect 57 The process of aspect 55 or 56, further comprising agitating the second admixture for from at least 5 minutes to about 30 minutes prior to performing step (c).
  • Aspect 58 The process of any one of aspects 55-57, further comprising agitating the solution for from about 10 minutes to about 30 minutes in step (c).
  • Aspect 59 The process of any one of aspects 55-58, wherein the water is present in an amount of about 5 to about 35 wt% of the solution.
  • Aspect 60 The process of any one of aspects 55-59 wherein the oxidative compound comprises sodium hypochlorite, calcium hypochlorite, hydrogen peroxide, or any combination thereof.
  • Aspect 61 The process of any one of aspects 55-60, wherein the oxidative compound is present in an amount of from about 0. 13 to about 6 wt% of the solution.
  • Aspect 62 The process of any one of aspects 55-61, wherein the one or more vitamins comprise ascorbic acid (vitamin C), biotin (vitamin B7), pantothenic acid (vitamin B6), retinol (vitamin A), tocopherol (vitamin E), derivatives thereof, and any combination thereof.
  • the one or more vitamins comprise ascorbic acid (vitamin C), biotin (vitamin B7), pantothenic acid (vitamin B6), retinol (vitamin A), tocopherol (vitamin E), derivatives thereof, and any combination thereof.
  • Aspect 63 The process of any one of aspects 55-62, wherein the one or more vitamins are present in an amount of from about 0.5 to about 1 wt% of the solution.
  • Aspect 64 The process of any one of aspects 55-63, further comprising adding an inorganic salt in any of step (a), step (b), or step (c).
  • Aspect 65 The process of aspect 64, wherein the inorganic salt comprises sodium chloride.
  • Aspect 66 The process of aspect 64 or 65, wherein the inorganic salt is present in an amount of from about 0.5 to about 2 wt% of the solution.
  • Aspect 67 The process of any one of aspects 55-66, wherein the organic acid comprises citric acid, lactic acid, glycolic acid, hyaluronic acid, a salt thereof, or any combination thereof.
  • Aspect 68 The process of any one of aspects 55-67, wherein the organic acid is present in an amount of from about 0.51 to about 2 wt% of the solution.
  • Aspect 69 The process of any one of aspects 55-68, wherein the monoalcohol comprises ethyl alcohol, isopropyl alcohol, or any combination thereof.
  • Aspect 70 The process of any one of aspects 55-69, wherein the monoalcohol is present in an amount of from about 60 wt% to about 70 wt% of the solution.
  • Aspect 71 The process of any one of aspects 55-70, wherein the polyalcohol comprises glycerin, butylene glycol, polyethylene glycol (PEG), or any combination thereof.
  • Aspect 72 The process of any one of aspects 55-71, wherein the polyalcohol is present in an amount of from about 3 wt% to about 10 wt% of the solution.
  • Aspect 73 The process of any one of aspects 55-72, further comprising adding one or more additional components to the second admixture in step (c), wherein the one or more additional components comprise a fragrance, an ingredient that imparts a color to the solution, or any combination thereof.
  • Aspect 74 The process of aspect 73, wherein the fragrance is present in an amount of from about 0.01 to 0.1 wt% of the solution.
  • Aspect 75 A single phase liquid solution produced by the process of any one of aspects 55-74.
  • a makeup tools cleanser comprising the solution of aspect 75.
  • An emulsion comprising (i) a gel phase comprising a bulking agent, water, a first oxidative compound, a monoalcohol, a second oxidative compound, and at least one organic acid; (ii) an oil phase comprising one or more of mineral oil, at least one silicone, and beeswax; and (iii) an emulsifier.
  • Aspect 78 The emulsion of aspect 77, further comprising a co-emulsifier.
  • Aspect 79 The emulsion of aspect 77 or 78, wherein the bulking agent is hydroxypropyl methyl cellulose.
  • Aspect 80 The process of aspect 79, wherein the hydroxypropyl methyl cellulose has an average molecular weight of about 4000 Da.
  • Aspect 81 The emulsion of aspect 79 or 80, wherein the hydroxypropyl methyl cellulose is present in an amount of from about 3.5 wt% to about 10 wt% of the emulsion.
  • Aspect 82 The emulsion of any one of aspects 77-81, wherein the water is present in an amount of from about 4.5 wt% to about 6 wt% of the emulsion.
  • Aspect 83 The emulsion of any one of aspects 77-82, wherein the first oxidative compound comprises sodium hypochlorite, calcium hypochlorite, or any combination thereof.
  • Aspect 84 The emulsion of any one of aspects 77-83, wherein the first oxidative compound is present in an amount of from about 0. 1 to about 0.3 wt% of the emulsion.
  • Aspect 85 The emulsion of any one of aspects 77-84, wherein the monoalcohol comprises ethyl alcohol, isopropyl alcohol, or any combination thereof.
  • Aspect 86 The emulsion of any one of aspects 77-85, wherein the monoalcohol is present in an amount of from about 60 wt% to about 70 wt% of the emulsion.
  • Aspect 87 The emulsion of any one of aspects 77-86, wherein the second oxidative compound comprises hydrogen peroxide.
  • Aspect 88 The emulsion of any one of aspects 77-87, wherein the second oxidative compound is present in an amount of from about 0.03 to about 1 wt% of the emulsion.
  • Aspect 89 The emulsion of any one of aspects 77-88, wherein the at least one organic acid comprises citric acid, lactic acid, glycolic acid, hyaluronic acid, a salt thereof, or any combination thereof.
  • Aspect 90 The emulsion of any one of aspects 77-89, wherein the at least one organic acid is present in an amount of from about 0.5 to about 2 wt% of the emulsion.
  • Aspect 91 The emulsion of any one of aspects 77-90, further comprising one or more vitamins.
  • Aspect 92 The emulsion of aspect 91, wherein the one or more vitamins comprise ascorbic acid (vitamin C), biotin (vitamin B7), pantothenic acid (vitamin B6), retinol (vitamin A), tocopherol (vitamin E), derivatives thereof, and any combination thereof.
  • the one or more vitamins comprise ascorbic acid (vitamin C), biotin (vitamin B7), pantothenic acid (vitamin B6), retinol (vitamin A), tocopherol (vitamin E), derivatives thereof, and any combination thereof.
  • Aspect 93 The emulsion of aspect 91 or 92, wherein the one or more vitamins are present in an amount of from about 0.01 to about 3 wt% of the emulsion.
  • Aspect 94 The emulsion of any one of aspects 78-93, wherein the co-emulsifier comprises bentonite.
  • Aspect 95 The emulsion of aspect 93 or 94, wherein the co-emulsifier is present in an amount of from about 0.01 to about 2 wt% of the emulsion.
  • Aspect 96 The emulsion of any one of aspects 77-95, further comprising an inorganic salt.
  • Aspect 97 The emulsion of aspect 96, wherein the inorganic salt comprises sodium chloride.
  • Aspect 98 The emulsion of aspect 96 or 97, wherein the inorganic salt is present in an amount of from about 0.5 to about 2 wt% of the emulsion.
  • Aspect 99 The emulsion of any one of aspects 77-98, wherein the mineral oil is present in an amount of from about 0.5 to about 10 wt% of the emulsion.
  • Aspect 100 The emulsion of any one of aspects 77-99, wherein the silicone comprises a dimethicone or a combination of dimethicone and cyclopentasiloxane.
  • Aspect 101 The emulsion of aspect 100, wherein the silicone comprises a combination of dimethicone and cyclopentasiloxane, and wherein the dimethicone is present in an amount of from 50 to 99.99 wt% in the combination.
  • Aspect 102 The emulsion of any one of aspects 77-101, wherein the silicone is present in an amount of from about 0.5 to about 10 wt% of the emulsion.
  • Aspect 103 The emulsion of any one of aspects 77-102, wherein the beeswax is present in an amount of from about 0.5 to about 10 wt% of the emulsion.
  • Aspect 104 The emulsion of any one of aspects 77-103, wherein the emulsifier comprises cetyl diglyceryl tris(trimethylsiloxy)silylethyl dimethicone.
  • Aspect 105 The emulsion of any one of aspects 77-104, wherein the emulsifier is present in an amount of from about 0.2 to about 3 wt% of the emulsion.
  • Aspect 106 The emulsion of any one of aspects 77-105, further comprising one or more additional components in the oil phase, wherein the one or more additional components comprise a natural oil, a skin conditioner, petroleum jelly, an antioxidant, a fragrance, an ingredient that imparts a color to the emulsion, or any combination thereof.
  • Aspect 107 The emulsion of aspect 106, wherein the natural oil comprises sea buckthorn oil, olive oil, hemp oil, coconut oil, or any combination thereof.
  • Aspect 108 The emulsion of aspect 106 or 107, wherein the natural oil is present in an amount of from about 0.01 to about 1 wt% of the emulsion.
  • Aspect 109 The emulsion of any one of aspects 106-108, wherein the skin conditioner comprises glycerin, polyethylene glycol (PEG), butylene glycol, polysorbate, a PEG-based surfactant, a PEG-based emulsifier, or any combination thereof.
  • the skin conditioner comprises glycerin, polyethylene glycol (PEG), butylene glycol, polysorbate, a PEG-based surfactant, a PEG-based emulsifier, or any combination thereof.
  • Aspect 110 The emulsion of any one of aspects 106-109, wherein the skin conditioner is present in an amount of from about 3 wt% to about 10 wt% of the emulsion.
  • Aspect 111 The emulsion of any one of aspects 106-110, wherein the fragrance comprises a fruit fragrance, a floral fragrance, an herbal fragrance, a spice fragrance, a fragrance derived from a beverage, or any combination thereof.
  • Aspect 112. The emulsion of any one of aspects 106-111, wherein the ingredient that imparts a color comprises a natural dye, an artificial dye, or any combination thereof.
  • Aspect 113 The emulsion of any one of aspects 106-112, wherein the petroleum jelly is present in an amount of from about 0.01 to about 10 wt% of the emulsion.
  • Aspect 114 The emulsion of aspect 106-113, wherein the antioxidant comprises butylated hydroxytoluene (BHT).
  • BHT butylated hydroxytoluene
  • Aspect 115 The emulsion of aspect 114, wherein the antioxidant is present in an amount of from about 0. 1 to about 5 wt% of the emulsion.
  • Aspect 116 The emulsion of any one of aspects 77-115, further comprising an emulsion stabilizer.
  • Aspect 117 The emulsion of aspect 116, wherein the emulsion stabilizer comprises a sodium acrylate/sodium acryloyldimethyl taurate copolymer, isohexadecane, polysorbate 80, or any combination thereof.
  • Aspect 118 The emulsion of aspect 116 or 117, wherein the emulsion stabilizer is present in an amount of from about 0. 1 to about 5 wt% of the emulsion.
  • a sanitizing lotion comprising the emulsion of any one of aspects 77-118.
  • a makeup cleanser comprising the emulsion of any one of aspects 77-118.
  • a single phase liquid solution comprising water, at least one oxidative compound, at least one monoalcohol, a polyalcohol, and one or more additional components selected from vitamins, organic acids, skin conditioners, fillers, bulking agents, and combinations thereof.
  • Aspect 122 The single phase liquid solution of aspect 121, wherein the water is present in an amount of about 5 to about 35 wt% of the solution.
  • Aspect 123 The single phase liquid solution of aspect 121 or 122, wherein the oxidative compound comprises sodium hypochlorite, calcium hypochlorite, hydrogen peroxide, or any combination thereof.
  • Aspect 124 The single phase liquid solution of any one of aspects 121-123, wherein the oxidative compound is present in an amount of from about 0. 13 to about 6 wt% of the solution.
  • Aspect 125 The single phase liquid solution of any one of aspects 121-124, wherein the one or more vitamins comprise ascorbic acid (vitamin C) , biotin (vitamin B7), pantothenic acid (vitamin B6), retinol (vitamin A), tocopherol (vitamin E), derivatives thereof, and any combination thereof.
  • the one or more vitamins comprise ascorbic acid (vitamin C) , biotin (vitamin B7), pantothenic acid (vitamin B6), retinol (vitamin A), tocopherol (vitamin E), derivatives thereof, and any combination thereof.
  • Aspect 126 The single phase liquid solution of any one of aspects 121-125, wherein the one or more vitamins are present in an amount of from about 0.5 to about 1 wt% of the solution.
  • Aspect 127 The single phase liquid solution of any one of aspects 121-126, further comprising an inorganic salt.
  • Aspect 128 The single phase liquid solution of aspect 127, wherein the inorganic salt comprises sodium chloride.
  • Aspect 129. The single phase liquid solution of aspect 127 or 128, wherein the inorganic salt is present in an amount of from about 0.5 to about 2 wt% of the solution.
  • Aspect 130 The single phase liquid solution of any one of aspects 121-129, wherein the organic acid comprises citric acid, lactic acid, glycolic acid, hyaluronic acid, a salt thereof, or any combination thereof.
  • Aspect 131 The single phase liquid solution of any one of aspects 121-130, wherein the organic acid is present in an amount of from about 0.51 to about 2 wt% of the solution.
  • Aspect 132 The single phase liquid solution of any one of aspects 121-131, wherein the monoalcohol comprises ethyl alcohol, isopropyl alcohol, or any combination thereof.
  • Aspect 133 The single phase liquid solution of any one of aspects 121-132, wherein the monoalcohol is present in an amount of from about 60 wt% to about 70 wt% of the solution.
  • Aspect 134 The single phase liquid solution of any one of aspects 121-133, wherein the polyalcohol comprises glycerin.
  • Aspect 135. The single phase liquid solution of any one of aspects 121-134, wherein the polyalcohol is present in an amount of from about 3 wt% to about 10 wt% of the solution.
  • Aspect 136 The single phase liquid solution of any one of aspects 121-135, wherein the bulking agent comprises hydroxypropyl methyl cellulose.
  • Aspect 137 The single phase liquid solution of aspect 136, wherein the hydroxypropyl methyl cellulose is present in an amount of from about 3.5 to about 10 wt% of the solution.
  • Aspect 138 The single phase liquid solution of any one of aspects 121-137, wherein the fdler comprises bentonite.
  • Aspect 139 The single phase liquid solution of aspect 138, wherein the bentonite is present in an amount of from about 0.01 to about 2 wt% of the solution.
  • a makeup tools cleanser comprising the solution of any one of aspects 121-139.
  • Hydroxypropyl methyl cellulose is weighed and added to an agitator with deionized water and sodium hypochlorite or calcium hypochlorite to form a first admixture.
  • the first admixture is agitated for at least 5 minutes.
  • Ethyl alcohol or isopropyl alcohol, an aqueous solution of hydrogen peroxide, citric acid, and ascorbic acid are added to the first admixture to form a second admixture.
  • bentonite can be added to the agitator vessel gradually, along with the ethyl alcohol or isopropyl alcohol.
  • the second admixture is agitated for at least 10 minutes or until no solids remain on the agitator wall.
  • the second admixture is transferred to a non-reactive container and allowed to gel for at least 24 hours.
  • Mineral oil, one or more cosmetic-grade silicones, and beeswax are placed in an agitator and agitated until they are in the liquid phase to form an oil phase admixture.
  • the agitator can be heated to assist in liquid formation.
  • Any optional ingredients are added to the oil phase including one or more vitamins, emulsifiers, and/or fillers.
  • the gelled second admixture or aqueous phase is added to the oil phase under vigorous agitation. Agitation is conducted for 30 minutes in intervals of 10 minutes.
  • Typical non-reactive containers include high density polyethylene (HDPE) and/or polypropylene (PP).
  • HDPE high density polyethylene
  • PP polypropylene
  • ascorbic acid, citric acid, malic acid, lactic acid, glycolic acid, and/or salts thereof are added to the agitator containing the first admixture and mixed to form a second admixture.
  • Ethyl alcohol or isopropyl alcohol and glycerin are added to the second admixture under agitation. Agitation is conducted for 30 minutes in intervals of 10 minutes.
  • a first exemplary formulation is prepared as an emulsion according to the procedure from Example 1 for use as a sanitizing hand lotion.
  • the first exemplary formulation contains no fragrance and is free from vitamins or vitamin precursors, additives, and the like.
  • This formulation is colorless and odorless and has an oil phase containing mineral oil, a silicone, and beeswax.
  • a second exemplary formulation includes lemon verbena fragrance and up to 2 wt% citric acid.
  • a third exemplary formulation includes a white tea and cherry blossom fragrance.
  • a fourth exemplary formulation includes olive oil as a component in the oil phase.
  • a fifth exemplary formulation includes hemp oil as a component in the oil phase.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Insects & Arthropods (AREA)
  • Zoology (AREA)
  • Cosmetics (AREA)

Abstract

Selon un aspect, la divulgation concerne des émulsions stables incorporant une phase huileuse et une phase alcoolique, les émulsions contenant un ou plusieurs composés oxydants, des acides organiques et, éventuellement, des crèmes revitalisantes, des vitamines, des parfums, et analogues. Les émulsions sont, selon un aspect, utiles en tant que lotions désinfectantes, traitements d'hydratation de la peau, et nettoyants ou démaquillants. Selon un autre aspect, les émulsions sont efficaces pour désinfecter la peau mais ne sont pas siccatives ni irritantes. La divulgation concerne également des solutions liquides à phase unique incorporant au moins un mono-alcool, un polyalcool et un ou plusieurs composés oxydants. Selon un aspect, les solutions sont utiles en tant que nettoyants d'outils de maquillage et de soins de toilette. Selon un autre aspect, la divulgation concerne des procédés de fabrication des émulsions et des solutions.
PCT/US2021/059825 2020-11-20 2021-11-18 Procédé de fabrication de lotion désinfectante pouvant être utilisée comme hydratant, démaquillant et pour d'autres utilisations WO2022109088A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US18/253,226 US20230414459A1 (en) 2020-11-20 2021-11-18 Process for making sanitizing lotion that can be used as a moisturizer, makeup remover and other uses

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063116374P 2020-11-20 2020-11-20
US63/116,374 2020-11-20

Publications (1)

Publication Number Publication Date
WO2022109088A1 true WO2022109088A1 (fr) 2022-05-27

Family

ID=81709774

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2021/059825 WO2022109088A1 (fr) 2020-11-20 2021-11-18 Procédé de fabrication de lotion désinfectante pouvant être utilisée comme hydratant, démaquillant et pour d'autres utilisations

Country Status (2)

Country Link
US (1) US20230414459A1 (fr)
WO (1) WO2022109088A1 (fr)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217641A (en) * 1991-08-19 1993-06-08 Morris Herstein Eye makeup remover
US5520918A (en) * 1992-09-14 1996-05-28 Mary Kay Cosmetics, Inc. Low irritant skin-cosmetic composition for daily topical use, its application and manufacture
US6139880A (en) * 1998-06-10 2000-10-31 Revlon Consumer Products Corporation Gel cosmetic compositions
US20040044078A1 (en) * 2000-11-29 2004-03-04 Rolf Kawa Cosmetic and/or pharmaceutical emulsions
US20100003330A1 (en) * 1999-04-28 2010-01-07 The Regents Of The University Of Michigan Antimicrobial nanoemulsion compositions and methods
CN104940930A (zh) * 2015-05-31 2015-09-30 黑龙江佰彤儿童药物研究有限公司 一种治疗儿童癫痫药物口服乳剂及其制备方法
US20150320653A1 (en) * 2009-03-09 2015-11-12 Coty Germany Gmbh Cosmetic base composition and its use
US20180344619A1 (en) * 2017-06-05 2018-12-06 Momentive Performance Materials Inc. Aqueous compositions for the treatment of hair
US20190054114A1 (en) * 2017-02-07 2019-02-21 Blue Sea Laboratories, S.L. Emulsion and method for the manufacture thereof

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5217641A (en) * 1991-08-19 1993-06-08 Morris Herstein Eye makeup remover
US5520918A (en) * 1992-09-14 1996-05-28 Mary Kay Cosmetics, Inc. Low irritant skin-cosmetic composition for daily topical use, its application and manufacture
US6139880A (en) * 1998-06-10 2000-10-31 Revlon Consumer Products Corporation Gel cosmetic compositions
US20100003330A1 (en) * 1999-04-28 2010-01-07 The Regents Of The University Of Michigan Antimicrobial nanoemulsion compositions and methods
US20040044078A1 (en) * 2000-11-29 2004-03-04 Rolf Kawa Cosmetic and/or pharmaceutical emulsions
US20150320653A1 (en) * 2009-03-09 2015-11-12 Coty Germany Gmbh Cosmetic base composition and its use
CN104940930A (zh) * 2015-05-31 2015-09-30 黑龙江佰彤儿童药物研究有限公司 一种治疗儿童癫痫药物口服乳剂及其制备方法
US20190054114A1 (en) * 2017-02-07 2019-02-21 Blue Sea Laboratories, S.L. Emulsion and method for the manufacture thereof
US20180344619A1 (en) * 2017-06-05 2018-12-06 Momentive Performance Materials Inc. Aqueous compositions for the treatment of hair

Also Published As

Publication number Publication date
US20230414459A1 (en) 2023-12-28

Similar Documents

Publication Publication Date Title
Yorgancioglu et al. Production of cosmetic purpose collagen containing antimicrobial emulsion with certain essential oils
JP4418976B2 (ja) 防腐殺菌剤及び化粧料組成物
JP2015178497A (ja) 潤滑、保湿、消毒や殺菌に使う半流体の組成物及びその使用方法
US20080044479A1 (en) Antimicrobial sanitizing formulations with skin protection properties
WO2009099443A1 (fr) Désinfectant des mains et procédé de préparation
CA2424003A1 (fr) Composition topique
US20100160454A1 (en) Antimicrobial agents, compositions and products containing the same, and methods of using the compositions and products
JP2011126862A (ja) 化粧料
US9844596B2 (en) Compositions for depositing agents using highly volatile silicone solvents
TW201815378A (zh) 化妝料
WO2022109088A1 (fr) Procédé de fabrication de lotion désinfectante pouvant être utilisée comme hydratant, démaquillant et pour d'autres utilisations
AU2006235798B2 (en) Topical composition
JP4294640B2 (ja) 防腐殺菌剤、該防腐殺菌剤を配合した化粧品又は医薬品、及び防腐殺菌方法
JP5264829B2 (ja) 防腐殺菌剤及び化粧料組成物
JP3658626B2 (ja) 化粧品および医薬部外品
WO2011040432A1 (fr) Agent de lavage oculaire
RU2599480C2 (ru) Средство для подавления роста волос
EP4171477A1 (fr) Lotion topique ayant des propriétés désinfectantes
JP7475785B2 (ja) 水中油型乳化組成物
RU2786973C1 (ru) Антибактериальное средство для обработки рук
JP2001206816A (ja) 皮膚軟化性と抗菌作用を有する乳液、化粧品製剤および皮膚洗浄用品
JP3979497B2 (ja) シート状パック化粧料
BE1022505B1 (nl) Methode voor het bereiden van een excipiëns geschikt voor het bereiden van cremes
JP2021080208A (ja) 化粧料組成物
BE1025392A1 (nl) Octenidinehydrochloride bevattende emulsies

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 21895555

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 18253226

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 21895555

Country of ref document: EP

Kind code of ref document: A1