WO2022068829A1

WO2022068829A1 - Sample acquisition apparatus, method and device, and medium

Info

Publication number: WO2022068829A1
Application number: PCT/CN2021/121407
Authority: WO
Inventors: 龚伟; 雷德杰; 张珥
Original assignee: 迈克医疗电子有限公司
Priority date: 2020-09-30
Filing date: 2021-09-28
Publication date: 2022-04-07
Also published as: CN112326984A

Abstract

Disclosed in the present application are a sample acquisition apparatus, method and device, and a medium. The apparatus comprises: a cache area used for placing a sample for which primary sampling is completed and no test result is generated; a transmission assembly used for moving the sample for which primary sampling is completed and no test result is generated to the cache area from a sampling position, the sampling position being a position where the sample undergoes primary sampling; and a control module used for acquiring the position information of a target sample after determining to retest the target sample placed in the cache area, and controlling, according to the position information, a sampling needle to move to a position right above the target sample and re-sample the target sample.

Description

Sample collection devices, methods, equipment and media

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims the priority of Chinese patent application 202011062763.0 filed on September 30, 2020, entitled "Sample Collection Method, Apparatus, Equipment and Medium", the entire content of which is incorporated herein by reference.

technical field

The present application belongs to the field of sample collection, and in particular, relates to a sample collection device, method, equipment and medium.

Background technique

The sample collection technology can be applied in the medical field to analyze and detect biological samples such as blood and urine. Specifically, a sample can be drawn from the sample container, and then analyzed and detected.

With the continuous progress of sample collection technology, the problem of how to improve the efficiency of sample collection needs to be solved urgently. During the detection process, the samples may need to be re-measured for various reasons, and the time spent in re-measurement has become a factor that affects the efficiency of sample collection. one of the important factors.

At this stage, after the sample is sampled, the sample needs to wait for the sampling result in place. If it needs to be re-checked, it will be re-sampled in place; if it is not necessary to re-check, the sample can be discarded after the detection is completed. In this way, each sample needs to spend time waiting for re-examination, which reduces the efficiency of sample collection.

SUMMARY OF THE INVENTION

The sample collection device, method, device, and medium provided by the embodiments of the present application can detect more samples in the same time, and improve the efficiency of sample collection.

In a first aspect, a sample collection device is provided, including:

The buffer area is used to place samples that have completed the initial sampling and have not generated test results;

The transmission component is used to move the samples that have completed the initial sampling and have not generated the detection result from the sampling position to the buffer area, wherein the sampling position is the position where the samples are initially sampled;

The control module is used to obtain the position information of the target sample after determining that the target sample placed in the buffer area is re-measured; according to the position information, control the sampling needle to move directly above the target sample and resample the target sample.

In an optional implementation manner, the transmission component specifically includes:

The transmission part is used to transmit the samples that have completed the initial sampling and have not generated the detection result from the sampling position to the buffer area;

The first pushing part is used for pushing the samples in the buffer area.

In an optional embodiment, the control module is specifically used for:

After each movement operation of the transmission component on the target sample is detected, the position information of the target sample is updated according to the movement direction of the target sample.

In an optional embodiment, the position information of the target sample includes: a first coordinate value representing the target sample in the conveying direction of the conveying member, and a second coordinate representing the target sample in the pushing direction of the first pushing member value;

The control module is specifically used for:

After each detection of a transmission operation of the transmission component to the target sample, the first coordinate value is updated, wherein the updated first coordinate value is the sum of the first coordinate value before the update and the first preset distance value;

The second coordinate value is updated after each detection of a pushing operation on the target sample by the first pushing component, wherein the updated second coordinate value is the sum of the second coordinate value before the update and the second preset distance value.

In an optional embodiment, the device further comprises a recovery area; the control module is further used for:

In the case that there are samples at the edge of the buffer area, determine whether the detection result of the samples at the edge of the buffer area has been generated;

If no detection result is generated, control the first push member to be in a waiting state;

If the detection result has been generated, the first pushing part is controlled to push the sample from the buffer area to the recovery area.

In an optional implementation manner, the accommodated number of samples in the buffer area is greater than or equal to a target ratio, and the target ratio is a ratio of the duration of a single detection of the sample to the transmission time interval of the transmission component.

In an optional embodiment, the device further includes:

Placement area for placing samples to be tested;

The transport assembly is also used to move the sample to be tested from the placement area to the sampling location.

In an optional embodiment, the transmission assembly includes:

a second pushing part for pushing the sample placed in the placement area to the conveying part;

The transfer part is used to transfer the sample to the sampling position, and transfer the sample that has completed the initial sampling and has not generated the detection result from the sampling position to the buffer area;

The first pushing part is used for pushing the samples in the buffer area.

In a second aspect, a sample collection device is provided, including: a routine sample injection module and an emergency sample injection module;

Among them, the routine sample injection module includes:

The buffer area is used to place regular samples that have completed initial sampling and have not generated test results;

The first transmission component is used for moving the conventional samples that have completed the initial sampling and have not generated the detection result from the conventional sampling position to the buffer area, where the normal sampling position is the position where the conventional samples are initially sampled;

Among them, the emergency sample injection module includes:

The sample injection assembly includes a first transmission unit and an emergency sample rack, and the emergency sample rack reciprocates between the injection position and the emergency sampling position with the first transmission unit.

In an optional embodiment, the device further includes:

The control module is used to obtain the position information of the target regular sample after determining that the target regular sample placed in the buffer area is to be re-measured; according to the position information, control the sampling needle to move directly above the target regular sample and carry out the measurement of the target regular sample. resampling.

A third aspect provides a sample collection method, which is applied to the sample collection device provided by the first aspect, any optional embodiment of the first aspect, the second aspect, or any optional embodiment of the second aspect, include:

After it is determined that the target sample placed in the buffer area is re-measured, the location information of the target sample is obtained;

According to the position information, control the sampling needle to move directly above the target sample;

After the sampling needle is moved directly above the target sample, the control sample is resampled against the target sample.

In a fourth aspect, a sample collection device is provided, comprising: a memory for storing a program;

The processor is configured to run the program stored in the memory to execute the sample collection method provided by the third aspect or any optional implementation manner of the third aspect.

A fifth aspect provides a machine-readable storage medium, where computer program instructions are stored on the machine-readable storage medium, and when the computer program instructions are executed by a processor, the third aspect or any optional implementation manner of the third aspect is provided. method of sample collection.

According to the sample collection device, method, device, and medium in the embodiments of the present application, a target sample that has been sampled and no detection result has been generated can be placed by setting a buffer area, and after it is determined to retest the target sample placed in the buffer area, Obtain the position information of the target sample; according to the position information, control the sampling needle to move directly above the target sample and re-measure the target sample. Since the sample can be placed in the buffer area in the process of completing the sampling and waiting for the sampling result, the continued sampling and detection of other samples will not be affected. Therefore, more samples can be detected while the samples are waiting for the detection result, which improves the sample collection efficiency.

Description of drawings

In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the following briefly introduces the accompanying drawings required for the description of the embodiments or the prior art. Obviously, the drawings in the following description are only These are some embodiments of the present application. For those of ordinary skill in the art, other drawings can also be obtained based on these drawings without any creative effort.

FIG. 1 is a schematic structural diagram of a sample collection device provided by an embodiment of the first aspect of the present application;

2 is a schematic structural diagram of another sample collection device provided by an embodiment of the first aspect of the present application;

3 is a schematic flowchart of a sample sampling process of another sample collection device provided by an embodiment of the first aspect of the present application;

4 is a schematic structural diagram of another sample collection device provided by an embodiment of the first aspect of the present application;

5 is a plan view of an example of the sample detection device involved in the present application;

FIG. 6 is a schematic structural diagram of an exemplary sample collection device when sampling a sampling location provided by an embodiment of the first aspect of the present application;

7 is a schematic structural diagram of an exemplary sample acquisition device when sampling a buffer area provided by an embodiment of the first aspect of the present application;

8 is a schematic flowchart of a sample collection method provided by an embodiment of the third aspect of the present application;

FIG. 9 shows a schematic diagram of a hardware structure of a sample collection device provided by an embodiment of the fourth aspect of the present application.

Detailed ways

The features and exemplary embodiments of various aspects of the present application will be described in detail below. In order to make the purpose, technical solutions and advantages of the present application more clear, the present application will be further described in detail below with reference to the accompanying drawings and specific embodiments. It should be understood that the specific embodiments described herein are only intended to explain the present application, but not to limit the present application. It will be apparent to those skilled in the art that the present application may be practiced without some of these specific details. The following description of the embodiments is merely to provide a better understanding of the present application by illustrating examples of the present application.

It should be noted that, in this document, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any relationship between these entities or operations. any such actual relationship or sequence exists. Moreover, the terms "comprising", "comprising" or any other variation thereof are intended to encompass a non-exclusive inclusion such that a process, method, article or device that includes a list of elements includes not only those elements, but also includes not explicitly listed or other elements inherent to such a process, method, article or apparatus. Without further limitation, an element defined by the phrase "comprises" does not preclude the presence of additional identical elements in a process, method, article, or device that includes the element.

During the sample collection process, the sample may need to be retested for various reasons. The existing sample re-measurement method needs to wait for the sampling result in place after the sample is sampled. When a batch of samples needs to be tested, the analytical instrument spends a separate period of time waiting for the test results for each sample, which greatly affects the detection efficiency.

In a related technical solution, in order to improve the detection efficiency, after the sample in the test tube is sampled, the sample in the test tube is transferred to the buffer cup inside the instrument through the sample needle for retention until all the test results of the sample are obtained. . If a retest is required, the detection is resampled from this cache cup, and if no retest is required, the cache cup is discarded. In this way, at least one cache cup needs to be wasted for each detection, and the detection cost is high.

In another related technical solution, when the sample needs to be re-measured, the sample can be re-moved to the sample needle in a rollback or circular manner for sampling and re-measurement. In this way, it takes time to re-move the sample to the sample needle during re-measurement, which affects the detection efficiency and makes it difficult to schedule the sample.

In order to solve at least one of the above problems, the embodiments of the present application provide a sample collection solution. The sample collection device provided by the embodiment of the present application is first introduced below.

FIG. 1 is a schematic structural diagram of a sample collection device according to an embodiment of the first aspect of the present application. The sample collection device shown in FIG. 1 includes a buffer area 11, a transmission component and a control module (not shown in the figure).

The buffer area 11, the transmission component and the control module will be described in detail below.

First, the buffer area 11 is used for storing samples that have completed the initial sampling and have not generated detection results.

In some embodiments, the buffer area 11 may comprise a partial area on the base of the sample collection device. It should be noted that, in FIG. 1 , the buffer area 11 has an overlapping area overlapping with the conveying member 121 . That is, part of the transfer part 121 is provided in the buffer area 11 .

In some embodiments, a sample in this application refers to a sample that can be aspirated by a sample needle. Specifically, it may be a biological sample such as blood or urine, or may be a biological reagent, and the type of the sample is not specifically limited.

In some embodiments, the sample is placed in a sample holder. Correspondingly, one or more sample racks can be placed in the buffer area 11, and each sample rack is placed with a plurality of sample containers. Wherein, each sample container holds the sample reagent remaining after the initial sampling.

In some embodiments, the accommodating quantity M of samples in the buffer area 11 is greater than or equal to the target ratio C. The target ratio C is the ratio of the single detection time T1 of the sample to the transmission time interval t2 of the transmission part 121. Wherein, the single detection duration T1 of the sample is the duration from sampling to obtaining the detection result of the sample. The transmission time interval of the transmission part 121 is the time difference between two adjacent transmissions of the transmission part 121 . For example, if the transmission unit 121 performs the next transmission at an interval of 2s after one transmission, the transmission time interval of the transmission unit 121 is t2=2s. As a specific example, if the single detection duration T1 of a sample is 300s, and the transmission unit 121 transmits once every 10s, the storage quantity M of the samples in the buffer area 11 is greater than or equal to 300/10=30. At this time, if each sample rack can accommodate 10 samples, the buffer area needs to accommodate at least 3 sample racks. If each sample rack can hold 5 samples, the buffer area needs to hold at least 6 sample racks.

It should be noted that the samples in the embodiments of the present application may refer to sample containers such as test tubes and reaction cups, and samples in the sample containers.

Next, after the introduction of the buffer area 11, the following parts of the embodiments of the present application will describe the transmission components in detail.

For the transmission component: the transmission component is used to move the samples for which the initial sampling has been completed and no detection result has been generated from the sampling position 13 to the buffer area 11 .

Among them, the sampling position 13 is used to place the sample that is being sampled for the first time. That is, the sampling position 13 is the position where the sample is initially sampled. It should be noted that, in the process of sampling the sample for the first time, the sample needle is located directly above the sampling position 13 .

In some embodiments, the transport assembly is an assembly capable of driving the sample to move in one of multiple ways, such as pushing, driving, and conveying, or a combination of multiple ways. Exemplarily, the transmission assembly can move the sample by one transmission part, or can move the sample with the cooperation of multiple transmission parts, and the transmission mode and the number of parts of the transmission assembly are not limited.

In one embodiment, as shown in FIG. 1 , the transmission assembly includes: a conveying part 121 and a first pushing part 122 .

The transfer part 121 is used for transferring the samples for which the initial sampling is completed and the detection result is not generated from the sampling position to the end of the transfer part 121 close to the buffer area 11 . Illustratively, it can be forwarded to a first position of the transfer member 121 , which can be one end of the transfer member 121 . For example, the first position may be the farthest end of the conveying member 121 in its conveying direction (eg, the Y direction in FIG. 1 ) (eg, the leftmost end of the conveying member 121 in FIG. 1 ).

In some examples, the conveying member 121 may be composed of a conveying belt and a driving part. Wherein, the driving part may include a driving motor and a rotating shaft that drives the conveyor belt in a frictional manner. Alternatively, the driving part may include a rotating shaft and a chain.

In other examples, the conveying part 121 may be composed of a pushing part and a driving part. Wherein, the driving part may be located below the sliding rail, and the pushing part may be located above the sliding rail. The pushing part can move along the driving direction along the sliding rail with the driving part, and accordingly, the sample moves along the driving direction under the pushing of the pushing part. Exemplarily, the push portion may be a push rod, a push block, a push piece, etc., and the specific structure of the push portion is not limited.

In yet other examples, the transfer member 121 may consist of a rocker and a link. When the pendulum rod makes a circular motion, it can drive the connecting rod to move along the conveying direction. The connecting rod can push the sample to move along the conveying direction. Wherein, the specific structures of the connecting rod and the swing rod are not limited.

In still other examples, the transmission component 121 may be an actuator that converts other forms of energy into mechanical energy, such as an air cylinder, a hydraulic cylinder, an electric cylinder, and performs linear reciprocating motion (or oscillating motion). The specific structure of the actuator is not limited.

To sum up, the conveying component 121 may be a conveying assembly with various structures, and the specific type thereof is not limited. It should be noted that, although the transfer member 121 can move the sample, the sampling position 13 is fixed and does not move with the transfer member 121 .

After the introduction of the conveying member 121 , the following parts of the embodiments of the present application will specifically describe the first pushing member 122 that is used in conjunction therewith.

For the first pushing member 122 , it is used to push the samples in the buffer area 11 .

For the specific structure of the first pushing member 122, reference may be made to the relevant description of the transmission member 121 in the above embodiments of the present application, which will not be repeated here. For example, referring to FIG. 1 , the first pushing member may include a driving part (not shown in the figure) located under the buffer area 11 and an L-shaped pushing part.

Next, after the introduction of the transmission component, the following parts of the embodiments of the present application will specifically describe the control module.

For the control module, it is used to obtain the position information of the target sample after it is determined that the target sample placed in the buffer area 11 is to be re-measured. And, according to the position information of the target sample, the sampling needle is controlled to move directly above the target sample and the target sample is resampled.

Wherein, the target sample may be the sample to be retested in the above-mentioned samples. It should be noted that if the sample has been sampled N times in a single detection process, the first sampling is called the first sampling, and the second sampling to the Nth sampling after that is called re-sampling.

In some embodiments, the control module is specifically configured to update the position information of the target sample according to the moving direction of the target sample after detecting a moving operation of the target sample by the transmission component. Exemplarily, since the target sample moves in the conveying direction of the conveying member and moves in the pushing direction of the first pushing member. Therefore, the position information in the above two directions can be updated.

In one embodiment, the position information of the target sample includes: a first coordinate value y representing the target sample in the conveying direction of the conveying member (in the Y direction in FIG. 1 ), and a first coordinate value y representing the pushing direction of the first pushing member The second coordinate value of the upper target sample.

The control module is specifically used for:

The first coordinate value y is updated every time a transfer operation of the target sample by the transfer part 121 is detected. The updated first coordinate value is the sum of the first coordinate value before the update and the first preset distance value. Exemplarily, the first preset distance value may be a preset value or a real moving distance. For example, the first preset distance value may be equal to -1. It should be noted that, the specific value of the first preset distance value may be set according to the actual scene and application environment, which will not be repeated in this application.

After each detection of a pushing operation of the first pushing component 122 on the target sample, the second coordinate value x is updated, wherein the updated second coordinate value is the sum of the second coordinate value before the update and the second preset distance value value. Exemplarily, the second preset distance value may be a preset value or a real moving distance. For example, the second preset distance value may be equal to 1. It should be noted that, the specific value of the first preset distance value may be set according to the actual scene and application environment, which will not be repeated in this application.

In one embodiment, the location information of the samples at the sampling locations may be set to initial values (y ₀ , x ₀ ). Wherein, y ₀ can be determined with the number of samples that can be accommodated between the sampling position 13 and the first position of the conveying part 121 . If there are 10 samples in between, you can set y ₀ to 10. x ₀ can be set to 1.

Exemplarily, when the sample tube 31 has just entered the buffer area 11, the coordinate of the sample tube 31 is (1, 10), and when the transfer part 121 moves to the left by one sample tube position again, the coordinate of the sample tube 31 is (1, 9). ), that is, when any sample tube enters the transfer part 121 and the transfer part 121 moves one sample tube position to the left, the abscissa y of the sample tube decreases by 1. After the entire sample rack 20 completely enters the buffer area 11, the sample rack 20 moves longitudinally by one sample rack position under the action of the first pushing member 122, and the coordinate of the sample tube 31 is (2, 1). The first pushing member 122 acts on the sample rack 20 again to move a sample rack longitudinally. At this time, the coordinate of the sample tube 31 is (3, 1). The first pushing member 122 moves the sample rack 20 longitudinally by one sample rack position each time. The abscissa y of the sample tube 31 is incremented by 1. The position coordinates (y, x) of each sample tube can be obtained by the number of times the conveying member 121 and the first pushing member 122 act on the sample rack 200 . While the position coordinates (y, x) of the sample tube 31 are dynamically changing, after the sample tube 31 is resampled, the first pushing member 122 continues to push the sample holder 20 to push the sample holder 20 out of the buffer area 11 .

According to the embodiment of the present application, by setting a buffer area, a target sample that has been sampled and no detection result has been generated can be placed, and after it is determined that the target sample placed in the buffer area is re-measured, the location information of the target sample is obtained; according to the location information, Control the sampling needle to move directly above the target sample and re-measure the target sample. Since the sample can be placed in the buffer area in the process of completing the sampling and waiting for the sampling result, the continued sampling and detection of other samples will not be affected. Therefore, more samples can be detected while the samples are waiting for the detection result, which improves the sample collection efficiency.

In some embodiments, the buffer area 11 has a receiving cavity. Exemplarily, the accommodating cavity may be a groove of a buffer area. At this time, the sample collection device further includes a fixing part.

Wherein, the fixing member is accommodated in the accommodating cavity. Specifically, the fixing member can fix the sample. Optionally, if the fixing member is a clamping block, a corresponding clamping groove may be provided at the bottom of the sample holder on which the sample is placed. When the clamping groove at the bottom of the sample holder is clamped with the fixing component, the sample holder can be fixed, thereby realizing the fixing of the sample in the sample holder. Specifically, the fixing member may be an elongated block extending along the pushing direction of the first pushing member. Alternatively, in order to improve its own fixing performance, the fixing member may be a cross-shaped clamping block, a T-shaped clamping block or an L-shaped clamping block, and its specific shape is not limited.

Correspondingly, the control module is further configured to, after it is determined that the target sample placed in the buffer area 11 is to be re-measured, control the fixing member to extend from the accommodating cavity, so as to use the fixing member and the first pushing member 122 to jointly clamp the target sample. Hold fixed. Wherein, the fixing member may extend completely or partially from the accommodating cavity, and the extending manner is not limited.

In some embodiments, both the fixing part and the accommodating cavity are located at the edge of the buffer area 11 . When resampling any sample in the buffer area 11, the fixing member fixes the sample holder placed at the edge of the buffer area. That is, the last sample rack in the buffer area is fixed.

At this time, the first pushing part 122 can provide a force along the pushing direction of the sample holder to the first sample holder, and the fixing part can provide a force opposite to the pushing direction of the sample holder. Under the action of two opposite forces, the samples in the buffer area can be fixed, thereby realizing the fixation of the target sample.

In the embodiment of the present application, when the sample does not need to be re-measured, the fixing component can be accommodated in the accommodating cavity, and the movement and advancement of the sample are not affected. When re-measurement is required, the sample can be clamped and fixed, which can avoid the problem of decreased detection accuracy caused by sample offset and sample shaking, thereby improving the detection accuracy.

In some embodiments, the sample in Figure 1 may be a routine sample or an emergency sample. Among them, routine samples are samples that are tested in accordance with routine procedures, and emergency samples represent samples that need to be tested prior to routine samples.

FIG. 2 is a schematic structural diagram of another sample collection device provided by an embodiment of the first aspect of the present application. The difference between the sample collection device shown in FIG. 2 and the sample collection device shown in FIG. 1 is that the sample collection device shown in FIG. 2 further includes a placement area 14 .

Specifically, the placement area 14 is used to place the sample to be detected. In some embodiments, the placement area 14 may include a portion of the area on the base of the sample collection device.

In some embodiments, the sample holder can be placed in the placement area 14 in a manual placement manner or a mechanical placement manner to place the sample to be tested. The specific placement method of the sample and the sample holder is not specifically limited.

Correspondingly, in the case where the sample collection device includes the placement area 14 , the transmission assembly is also used to move the sample to be detected from the placement area 14 to the sampling position 13 . The manner in which the transmission component moves from the placement area 14 to the sampling position 13 may refer to the relevant descriptions in the above-mentioned parts of the embodiments of the present application, and details are not described herein again.

In the embodiment of the present application, by setting the placement area 14, since the placement area 14 can place a large number of samples to be detected, batch sampling of the samples can be realized. In addition, there is no need to manually place a new sample to be detected in real time, which improves the automation of the sample sampling process.

In some embodiments, the transport component 121 of the transport assembly can move the sample to be tested from the placement area 14 to the sampling location 13 .

In some embodiments, the transport member 121 of the transport assembly may cooperate with other transport members to move the sample to be tested from the placement area 14 to the sampling location 13 . Continuing to refer to FIG. 2 , the transmission assembly further includes a second pushing member 123 .

The second pushing part 123 is used for pushing the sample placed in the placing area 14 to the second position of the conveying part 121 . Illustratively, the second location may be the other end of the transfer member 121 . For example, the second position may be the closest end of the conveying member 121 in its conveying direction (eg, the Y direction in FIG. 1 ) (eg, the rightmost end of the conveying member 121 in FIG. 1 ). In one example, the second pushing part 123 pushes the sample placed at one end of the placing area 14 away from the conveying part 121 (such as the position near the bottom end of the placing area 14 in FIG. 1 ) to the second position or placing area of the conveying part 121 After the end of 14 close to the transfer part 121 (such as the position close to the top of the placing area 14 in FIG. 1 ), it will return to the original position, that is, the end of the placing area 14 away from the conveying part 121, to wait for a new sample to be placed.

At this time, the transfer component 121 is specifically configured to transfer the samples at the second position to the sampling position 13 , and transfer the samples for which the initial sampling is completed and no detection result is generated from the sampling position 13 to the buffer area.

In some embodiments, the sample collection device further includes a first sensor for detecting whether the sample has reached the second position of the transport member. In one embodiment, the first sensor may include a signal transmitting unit and a signal receiving unit, and the signal transmitting unit and the signal receiving unit may be respectively disposed on two adjacent sides of the transmission assembly. Exemplarily, continuing to refer to FIG. 2 , the signal transmitting unit may be disposed at the position D1, and the signal receiving unit may be disposed at the position D2.

Specifically, the first sensor may be a contact sensor or a non-contact sensor, and the first sensor may be a photoelectric sensor, a pressure sensor, a capacitance sensor, or the like, which can determine the arrival of the sample at the second position. Taking a photoelectric sensor as an example, the first sensor may be a proximity sensor, a through-beam photoelectric sensor, or the like. Specifically, for example, in order to improve the detection accuracy, the first sensor is a proximity sensor capable of sensing the proximity of an object. It should be noted that, the embodiment of the present application does not limit the specific type of the first sensor.

In some embodiments, the sample collection device further includes a second sensor for detecting whether a sample is placed in the placement area 14 . If a sample is placed, the second pushing part 123 is controlled to push the sample toward the direction of the conveying assembly. In one embodiment, the second sensor may include a signal transmitting unit and a signal receiving unit. Exemplarily, continue to refer to Fig. 2, the signal transmitting unit may be arranged at the position D3, and the signal receiving unit may be arranged at the position D4. With this arrangement, once the sample is placed in the placement area 14, the presence of the sample can be detected, which improves the detection accuracy. Exemplarily, in order to expand the detection range, the second sensor is a through-beam photoelectric sensor. In addition, for other details of the second sensor, reference may be made to the relevant description of the first sensor in the foregoing part of the embodiment of the present application, which will not be repeated here.

In some embodiments, the sample detection device further includes a third sensor for detecting whether a sample arrives in the buffer area 11 . Specifically, for the technical details of the third sensor, reference may be made to the relevant description of the first sensor in the foregoing part of the embodiment of the present application, which will not be repeated here.

In some embodiments, the sample collection device further includes a sample identification reading module. In one embodiment, the sample identification reading module is disposed near the sampling position 13 and on the side of the opposite direction of transmission (eg, the right side of the sampling device 13 in FIG. 2 ). The sample identification reading module is used for reading the sample identification. The sample identifier may be an image code, such as an image code, a barcode, or the like, which can represent sample information. Exemplarily, the sample identification reading module may be a barcode reader, and the specific type of the sample identification reading device is not limited.

In some embodiments, the sample collection device includes a sample identification reading module and a corresponding clamping assembly at the same time. The clamping assembly can clamp and rotate the sample container containing the sample, so that the sample identification reading module can scan the sample identification on the container wall of the sample container. Illustratively, the clamp assembly may include a drive assembly, a push-pull plate, a clamp, and a rotating wheel. Specifically, one end of the push-pull plate is provided with a clamp, and the push-pull plate drives the clamp to reciprocate between two positions along the preset direction with the second drive assembly, so as to keep the clamp away from or clamp the emergency test tube. In an example, in a target direction perpendicular to the conveying direction of the conveying part (such as the X direction in FIG. 2 ), the clamping assembly and the sample identification reading module may be disposed on both sides of the conveying part, respectively.

In some embodiments, FIG. 3 is a schematic flowchart of a sample sampling process of another sample collection device provided in the first aspect of the embodiments of the present application.

As shown in FIG. 3 , when the sample holder 20 is placed in the placing area 14 , the second pushing member 123 moves from the original position to the position P1 , and at this time, the sample holder 20 is pushed by the second pushing member 123 and moves to the position P2.

Next, after it is determined that the sample rack 20 arrives at the position P2, the conveying part 121 conveys the sample rack to the position P3, at which time the sample tubes 31 in the sample rack 20 arrive at the sampling position 13. Then, the transfer part 121 transfers the other samples in the sample rack 20 to the sampling position 13 in sequence, and transfers the sample rack to the position P4 after all the samples in the sample rack 20 are detected. When it is determined that the sample rack 20 reaches the position P4 of the conveying member 121 , the first pushing member 122 moves along the X direction by a preset distance to reach the position P6. At this time, the sample rack 20 is pushed by the first pushing member 122 to move a predetermined distance. Set the distance to the arrival position P5.

After that, the sample rack 20 waits for the detection results in the buffer area 11 when the detection results of all the samples on the sample rack 20 are not completely generated.

It should be noted that, if another sample rack arrives at the position P4 in the process of waiting for the detection result, the sample rack 20 continues to move in the X direction under the push of the other sample rack.

FIG. 4 is a schematic structural diagram of another sample collection device provided by the first aspect of the embodiment of the present application. The difference between the sample collection device shown in FIG. 4 and the sample collection device shown in FIG. 1 is that the sample collection device shown in FIG. 4 further includes a recovery area 15 . Among them, the recovery area 15 is used for placing samples to be discarded. Illustratively, samples for which test results have been obtained may be placed in the recovery area.

As shown in FIG. 4 , the recycling area 15 and the conveying part 121 may be located on both sides of the buffer area 11, respectively. Specifically, since a plurality of sample racks can be placed in the buffer area, when the first push member 122 pushes a new sample rack into the buffer area 11, other sample racks can be pushed to the first push member 122 by the new sample rack. The direction (such as the X direction in Figure 4) continues to move. until it moves to the recycling area 15.

By setting the recovery area 15, the samples that have been tested can be processed and recovered in time.

In some embodiments, in order to reduce the possibility of erroneously discarding samples, in the sample collection device shown in FIG. 4 , the control module is further used for the following three steps.

In the first step, when there are samples at the edge of the buffer area 11, it is determined whether the detection result of the samples at the edge of the buffer area 11 has been generated.

In the second step, if the detection result of the samples at the edge of the buffer area is not generated, the first pushing component 122 is controlled to be in a waiting state. That is, at this time, the first pushing member 122 stops moving. It should be noted that, if there are multiple samples at the edge of the buffer area 11, as long as the detection result of at least one sample among the multiple samples has not been generated, the first pushing device 122 can be controlled to be in a waiting state.

In the third step, if the detection result has been generated, the first pushing component 122 is controlled to push the sample from the buffer area 11 to the recovery area 15 .

In some examples, whether there is a sample at the edge of the buffer area 11 can be determined by setting a fourth sensor at the boundary between the buffer area 11 and the reclaim area 15 .

In other embodiments, whether the sample moves to the edge of the buffer area 11 can be determined according to the position information of the sample. For example, if the pushing direction of the first pushing member 122 is regarded as the column direction, the conveying direction of the conveying member 121 is regarded as the row direction. Then, it can be determined whether the samples are moved to the edge of the buffer area 11 according to the maximum number of columns of samples that the buffer area 11 can accommodate. Exemplarily, if the buffer area 11 can accommodate a maximum of 11 columns of samples, and the position coordinate of a certain sample is (11, i), it is determined that it has moved to the edge of the buffer area 11 . where i is any integer.

It should be noted that, if the samples are placed on the sample racks, the number of sample racks can be the number of columns of the samples.

In addition, the embodiments of the present application provide an exemplary sample collection device. FIG. 5 is a top view of an exemplary sample collection device provided by an embodiment of the present application. As shown in FIG. 5 , the sample collection device may include a buffer area 11 , a transfer part 121 , a sampling position 13 , a placement area 14 , a recovery area 15 , a first sensor 16 , a third sensor 17 , a sample identification reading module 18 , and a sample rack 20. Sample tube 31, sample tube 32 and second position P2.

The buffer area 11 has an accommodation cavity 111 . The accommodating cavity 11 may communicate with the outside through the opening.

For the specific implementation of the above-mentioned components, reference may be made to the relevant descriptions of the above-mentioned embodiments of the present application, which will not be repeated here.

In some embodiments, since the control module needs to control the movement of the sample needle at the sampling position 13 and the buffer area 11 . The sample collection device provided in the embodiment of the present application may further include a sample needle and a drive device for the sample needle. FIG. 6 is a schematic structural diagram of an exemplary sample collection device when sampling a sampling position according to the first aspect of the embodiment of the present application.

FIG. 6 shows the sample acquisition device when sampling the sampling location 13 . As shown in FIG. 6 , the sample sampling device further includes: a sample needle 40 and a drive assembly 50 for the sample needle.

The drive assembly 50 of the sample needle includes an X-axis moving device 51 , a Y-axis moving device 52 and a Z-axis moving device 53 . The sample needle 40 is moved to just above the sampling position 13 under the driving of the X-axis moving device 51 and the Y-axis moving device 52 of the drive assembly 50 . Then, under the control of the Z-axis moving device 53, it extends under the liquid surface of the sample to perform the first sampling.

In some embodiments, the drive assembly 50 of the sample needle is suspended in the air. The X-axis moving means 51, the Y-axis moving means 52, and the Z-axis moving means 53 are respectively movable in their respective extending directions. Optionally, the Y-axis moving device 52 is slidably connected to the frame of the sample collection device. The X-axis moving device 51 is slidably connected to the Y-axis moving device 52 . The Z-axis moving device 53 is slidably connected to the X-axis moving device 51 . The sample needle 40 is fixed on the Z-axis moving device 53 .

Compared with the existing three-axis moving device, the sample needle drive assembly 50 provided in this embodiment can arbitrarily control the movement of each axis moving device at the same time, which improves the flexibility of the three-axis drive assembly 50 and improves the The scheduling ability of the sample needle is improved, the resampling time is shortened, and the sample detection efficiency is improved.

In some embodiments, the sample collection device also includes a liquid level sensor 60 . The liquid level sensor 60 is used to detect whether the sample needle 40 is in contact with the sample liquid level, so as to precisely control the sampling detection.

FIG. 7 is a schematic structural diagram of an exemplary sample acquisition device when sampling a buffer area provided by the first aspect of the embodiment of the present application.

As can be seen from FIG. 6 and FIG. 7 , the sample needle driving assembly 50 drives the sample needle 40 to move above the buffer area 11 .

In some embodiments, the sample sampling device provided by the embodiments of the present application further has a sample detection function. Exemplarily, the sample sampling device in the embodiment of the present application may be a blood analyzer. The sample may then be a blood sample to be tested.

In a second aspect of the present application, the embodiment provides a sample collection device, including a routine sample injection module and an emergency sample injection module.

Among them, the routine sample injection module includes:

A buffer area for regular samples that have completed initial sampling and have not generated test results.

The first transmission component is used for moving the regular samples whose initial sampling has been completed and the detection result has not been generated from the regular sampling position to the buffer area, where the regular sampling position is the position where the regular samples are initially sampled.

Among them, the emergency sample injection module includes:

According to the sample collection device of the embodiment of the present application, the routine detection efficiency can be ensured while realizing the emergency sampling function.

Other details of the sample collection device according to the embodiment of the present application are similar to the sample collection device described above with reference to the examples shown in FIG. 1 to FIG. 7 , and can achieve its corresponding technical effects.

FIG. 8 is a schematic flowchart of a sample collection method provided by an embodiment of the third aspect of the present application. The execution subject of each step of the method may be the control module of the sample collection module provided in the first aspect above. As shown in FIG. 8 , the sample collection method 800 in this embodiment may include the following steps:

Step S810, after it is determined that the target sample placed in the buffer area is to be re-measured, the location information of the target sample is acquired.

In step S820, according to the position information, the sampling needle is controlled to move directly above the target sample and the target sample is resampled.

According to the sample collection method of the embodiment of the present application, by setting a buffer area, a target sample that has been sampled and no detection result has been generated can be placed, and after it is determined that the target sample placed in the buffer area is re-measured, the location information of the target sample is obtained; According to the position information, the sampling needle is controlled to move directly above the target sample and the target sample is sampled and re-measured. Since the sample can be placed in the buffer area in the process of completing the sampling and waiting for the sampling result, the continued sampling and detection of other samples will not be affected. Therefore, more samples can be detected while the samples are waiting for the detection result, which improves the sample collection efficiency.

In some embodiments, step S820 may be specifically implemented as: updating the position information of the target sample according to the moving direction of the target sample after each movement operation of the target sample by the transmission component is detected.

In some embodiments, the location information of the target sample includes: a first coordinate value characterizing the target sample in the conveying direction of the conveying member, and a second coordinate value characterizing the target sample in the pushing direction of the first pushing member.

Step S820 may specifically include:

The first step is to update the first coordinate value after each detection of a transmission operation of the transmission component to the target sample, wherein the updated first coordinate value is the sum of the first coordinate value before the update and the first preset distance value. value;

In the second step, after each detection of a pushing operation by the first pushing member on the target sample, update the second coordinate value, wherein the updated second coordinate value is the second coordinate value before the update and the second preset distance value and value.

In some embodiments, the apparatus further includes a recovery area.

Sample collection methods also include:

The third step is to judge whether the detection result of the sample at the edge of the buffer area has been generated when there are samples at the edge of the buffer area;

In the fourth step, if the detection result is not generated, the first pushing member is controlled to be in a waiting state;

In the fifth step, if the detection result has been generated, the first pushing component is controlled to push the sample from the buffer area to the recovery area.

In some embodiments, the accommodated number of samples in the buffer area is greater than or equal to a target ratio, where the target ratio is a ratio of the duration of a single detection of the sample to the transmission time interval of the transmission component.

Other details of the sample collection method according to the embodiment of the present application are similar to the sample collection device described above in conjunction with the examples shown in FIGS.

FIG. 9 shows a schematic diagram of a hardware structure of a sample collection device provided by an embodiment of the present application.

The sample collection device may include a processor 901 and a memory 902 storing computer program instructions.

Specifically, the above-mentioned processor 901 may include a central processing unit (CPU), or a specific integrated circuit (Application Specific Integrated Circuit, ASIC), or may be configured as one or more integrated circuits implementing the embodiments of the present application.

Memory 902 may include mass storage for data or instructions. By way of example and not limitation, memory 902 may include a Hard Disk Drive (HDD), a floppy disk drive, a flash memory, an optical disk, a magneto-optical disk, a magnetic tape, or a Universal Serial Bus (USB) drive or two or more A combination of more than one of the above. Memory 902 may include removable or non-removable (or fixed) media, where appropriate. Memory 902 may be internal or external to the sample acquisition device, where appropriate. In certain embodiments, memory 902 is non-volatile solid state memory.

Memory may include read only memory (ROM), random access memory (RAM), magnetic disk storage media devices, optical storage media devices, flash memory devices, electrical, optical or other physical/tangible memory storage devices. Thus, typically, a memory includes one or more tangible (non-transitory) machine-readable storage media (eg, memory devices) encoded with software including computer-executable instructions, and when the software is executed (eg, by a or multiple processors), it is operable to perform the operations described with reference to a method according to an aspect of the present disclosure.

The processor 901 reads and executes the computer program instructions stored in the memory 902 to implement any one of the sample collection methods in the foregoing embodiments.

In one example, the sample collection device may also include a communication interface 909 and a bus 910 . Among them, as shown in FIG. 9 , the processor 901 , the memory 902 , and the communication interface 903 are connected through the bus 910 and communicate with each other.

The communication interface 903 is mainly used to implement communication between modules, apparatuses, units and/or devices in the embodiments of the present application.

The bus 910 includes hardware, software, or both, coupling the components of the online data flow metering device to each other. By way of example and not limitation, the bus may include Accelerated Graphics Port (AGP) or other graphics bus, Enhanced Industry Standard Architecture (EISA) bus, Front Side Bus (FSB), HyperTransport (HT) Interconnect, Industry Standard Architecture (ISA) Bus, Infiniband Interconnect, Low Pin Count (LPC) Bus, Memory Bus, Microchannel Architecture (MCA) Bus, Peripheral Component Interconnect (PCI) Bus, PCI-Express (PCI-X) Bus, Serial Advanced Technology Attachment (SATA) bus, Video Electronics Standards Association Local (VLB) bus or other suitable bus or a combination of two or more of the above. Bus 910 may include one or more buses, where appropriate. Although embodiments of this application describe and illustrate a particular bus, this application contemplates any suitable bus or interconnect.

The sample collection device can execute the sample collection method in the embodiments of the present application, thereby implementing the sample collection method and apparatus described in conjunction with FIG. 1 to FIG. 7 .

In addition, in combination with the sample collection method in the foregoing embodiments, the embodiments of the present application may provide a machine-readable storage medium for implementation. Therefore, an embodiment of the fifth aspect of the present application provides a machine-readable storage medium on which computer program instructions are stored; when the computer program instructions are executed by a processor, any one of the above-mentioned sample collection methods is implemented Example. Examples of machine-readable storage media include non-transitory machine-readable storage media such as read only memory (ROM), random access memory (RAM), magnetic disk storage media devices, optical storage media devices, flash memory devices, electrical, optical or Other physical/tangible memory storage devices.

To be clear, the present application is not limited to the specific configurations and processes described above and illustrated in the figures. For the sake of brevity, detailed descriptions of known methods are omitted here. In the above-described embodiments, several specific steps are described and shown as examples. However, the method process of the present application is not limited to the specific steps described and shown, and those skilled in the art can make various changes, modifications and additions, or change the sequence of steps after comprehending the spirit of the present application.

The functional blocks shown in the above structural block diagrams may be implemented as hardware, software, firmware, or a combination thereof. When implemented in hardware, it may be, for example, an electronic circuit, an application specific integrated circuit (ASIC), suitable firmware, a plug-in, a function card, or the like. When implemented in software, elements of the present application are programs or code segments used to perform the required tasks. The program or code segments may be stored in a machine-readable medium or transmitted over a transmission medium or communication link by a data signal carried in a carrier wave. A "machine-readable medium" may include any medium that can store or transmit information. Examples of machine-readable media include electronic circuits, semiconductor memory devices, ROM, flash memory, erasable ROM (EROM), floppy disks, CD-ROMs, optical disks, hard disks, fiber optic media, radio frequency (RF) links, and the like. The code segments may be downloaded via a computer network such as the Internet, an intranet, or the like.

It should also be noted that the exemplary embodiments mentioned in this application describe some methods or systems based on a series of steps or devices. However, the present application is not limited to the order of the above steps, that is, the steps may be performed in the order mentioned in the embodiment, or may be different from the order in the embodiment, or several steps may be performed simultaneously.

Aspects of the present disclosure are described above with reference to flowchart illustrations and/or block diagrams of methods, apparatus, devices, and computer program products according to embodiments of the disclosure. It will be understood that each block of the flowchart illustrations and/or block diagrams, and combinations of blocks in the flowchart illustrations and/or block diagrams, can be implemented by computer program instructions. These computer program instructions may be provided to a processor of a general purpose computer, special purpose computer, or other programmable data processing apparatus to produce a machine such that execution of the instructions via the processor of the computer or other programmable data processing apparatus enables the Implementation of the functions/acts specified in one or more blocks of the flowchart and/or block diagrams. Such processors may be, but are not limited to, general purpose processors, special purpose processors, application specific processors, or field programmable logic circuits. It will also be understood that each block of the block diagrams and/or flowchart illustrations, and combinations of blocks in the block diagrams and/or flowchart illustrations, can also be implemented by special purpose hardware for performing the specified functions or actions, or by special purpose hardware and/or A combination of computer instructions is implemented.

The above are only specific implementations of the present application, and those skilled in the art can clearly understand that, for the convenience and brevity of description, the specific working process of the above-described systems, modules and units can be referred to in the foregoing method embodiments. The corresponding process is not repeated here. The above descriptions are only preferred embodiments of the present application, and are not intended to limit the present application. For those skilled in the art, various modifications and changes may be made to the embodiments of the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of this application shall be included within the protection scope of this application.

Those skilled in the art should understand that the above-mentioned embodiments are all illustrative and not restrictive. Different technical features appearing in different embodiments can be combined to achieve beneficial effects. Those skilled in the art should be able to understand and implement other variant embodiments of the disclosed embodiments on the basis of studying the drawings, the description and the claims. In the claims, the term "comprising" does not exclude other means or steps; an item is intended to include one/one or more/kinds of items when not modified by a quantifier, and may be combined with "one/one or more/kinds of items" "Used interchangeably"; the terms "first", "second" are used to designate names and not to indicate any particular order. Any reference signs in the claims should not be construed as limiting the scope of protection. The functions of multiple parts appearing in the claims can be realized by a single hardware or software module. The appearance of certain technical features in different dependent claims does not mean that these technical features cannot be combined to achieve beneficial effects.

Claims

A sample collection device, comprising:

The buffer area is used to place samples that have completed the initial sampling and have not generated test results;

a transmission component, configured to move the sample that has completed the initial sampling and has not generated the detection result from the sampling position to the buffer area, where the sampling position is the position where the sample is initially sampled;

The control module is used to obtain the position information of the target sample after determining that the target sample placed in the buffer area is re-measured; according to the position information, control the sampling needle to move directly above the target sample and The target sample is resampled.
The apparatus of claim 1, wherein the transmission assembly specifically comprises:

a transmission component, configured to transmit the samples whose initial sampling has been completed and the detection result has not been generated from the sampling position to the buffer area;

The first pushing part is used for pushing the samples in the buffer area.
The device according to claim 1, wherein the control module is specifically configured to:

After each movement operation of the target sample by the transmission component is detected, the position information of the target sample is updated according to the movement direction of the target sample.
The apparatus according to claim 2, wherein the position information of the target sample comprises: a first coordinate value characterizing the target sample in the conveying direction of the conveying member, and a first coordinate value characterizing the target sample in the conveying direction of the first pushing member the second coordinate value of the target sample in the pushing direction;

The control module is specifically used for:

The first coordinate value is updated after each transmission operation of the target sample by the transmission component is detected, wherein the updated first coordinate value is the first coordinate value before the update and the first coordinate value before the update. A sum of preset distance values;

The second coordinate value is updated after each detection of a pushing operation of the first pushing component on the target sample, wherein the updated second coordinate value is the second coordinate value before the update The sum value with the second preset distance value.
The apparatus of claim 2, further comprising a recovery area;

The control module is also used for:

In the case that there is a sample at the edge of the buffer area, determine whether the detection result of the sample at the edge of the buffer area has been generated;

If the detection result is not generated, controlling the first pushing member to be in a waiting state;

If the detection result has been generated, the first pushing part is controlled to push the sample from the buffer area to the recovery area.
The apparatus according to claim 2, wherein the number of samples in the buffer area is greater than or equal to a target ratio, and the target ratio is a ratio of a single detection duration of a sample to a transmission time interval of the transmission component.
The device according to any one of claims 1-6, further comprising:

Placement area for placing samples to be tested;

The transfer assembly is also used to move the sample to be detected from the placement area to the sampling position.
The apparatus of claim 2, wherein the transmission assembly comprises:

a second pushing part for pushing the sample placed in the placement area to the conveying part;

the transfer component, configured to transfer the sample to the sampling position, and transfer the sample for which the initial sampling is completed and the detection result is not generated from the sampling position to the buffer area;

The first pushing part is used for pushing the samples in the buffer area.
The apparatus according to claim 2, wherein the buffer area has a receiving cavity, and the apparatus comprises:

a fixing part, the fixing part is accommodated in the accommodating cavity;

The control module is further configured to, after determining that the target sample placed in the buffer area is to be re-measured, control the fixing member to extend from the accommodating cavity, so as to use the fixing member and the first pushing member to work together. The target sample is clamped and fixed.
A sample collection device, comprising: a routine sample injection module and an emergency sample injection module, wherein,

The conventional sample injection module includes:

a buffer area for placing the conventional samples that have completed initial sampling and have not generated detection results;

a first transmission component, configured to move the regular sample that has completed initial sampling and has not generated a detection result from a regular sampling position to the buffer area, where the regular sampling position is a position where the regular sample performs initial sampling;

The emergency sample injection module includes:

The sample introduction assembly includes a first transmission unit and an emergency sample rack, and the emergency sample rack reciprocates between the injection position and the emergency sampling position with the first transmission unit.
The apparatus of claim 10, further comprising:

The control module is used to obtain the position information of the target regular sample after it is determined that the target regular sample placed in the buffer area is re-measured; according to the position information, control the sampling needle to move to the position of the target regular sample directly above and resample the target conventional sample.
A sample collection method, applied to the sample collection device according to claim 1, the method comprising:

After it is determined that the target sample placed in the buffer area is re-measured, the location information of the target sample is obtained;

According to the position information, control the sampling needle to move directly above the target sample;

After the sampling needle is moved directly above the target sample, the sample is controlled to be resampled for the target sample.
A sample collection device comprising:

memory for storing programs;

a processor, configured to run the program stored in the memory to execute the sample collection method according to any one of claims 11 .
A machine-readable storage medium having computer program instructions stored on the machine-readable storage medium, the computer program instructions implementing the sample collection method described in any one of claims 11 when the computer program instructions are executed by a processor.