WO2022059642A1 - Composition de dentifrice - Google Patents

Composition de dentifrice Download PDF

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Publication number
WO2022059642A1
WO2022059642A1 PCT/JP2021/033524 JP2021033524W WO2022059642A1 WO 2022059642 A1 WO2022059642 A1 WO 2022059642A1 JP 2021033524 W JP2021033524 W JP 2021033524W WO 2022059642 A1 WO2022059642 A1 WO 2022059642A1
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WO
WIPO (PCT)
Prior art keywords
dentifrice composition
mass
teeth
effect
sodium
Prior art date
Application number
PCT/JP2021/033524
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English (en)
Japanese (ja)
Inventor
瞳 水野
裕之 清水
Original Assignee
ライオン株式会社
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Publication date
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Priority to JP2022550546A priority Critical patent/JPWO2022059642A1/ja
Publication of WO2022059642A1 publication Critical patent/WO2022059642A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a dentifrice composition that is excellent in tooth stain removing effect and gloss-imparting effect, has a good usability, and is effective for tooth whitening.
  • whitening of teeth is an important issue for QOL (Quality of Life).
  • various techniques for whitening teeth have been studied mainly in oral compositions such as dentifrice compositions, and as a technique for removing stains on teeth and cleaning them cleanly, for example, stain stains due to condensed phosphate have been studied. Removal is known. However, it is expected that not only the stains on the teeth will be cleaned and whitened, but also the glossiness will be added to produce more beautiful teeth and a bright complexion, but colored stains such as stain stains will be removed and cleaned.
  • Patent Document 1 Japanese Unexamined Patent Publication No. 2007-161657 contains a combination of water-soluble pyrophosphate, lauryl sulfate and specific hydroxypropylmethyl cellulose, which has good usability and foaming, and has an excellent effect of removing tooth stains.
  • Patent Document 2 Japanese Unexamined Patent Publication No. 63-141920 proposes a calculus composition having an excellent effect of suppressing tartar formation, which contains a specific abrasive, a polyphosphate and a specific sodium carboxymethyl cellulose. However, these do not mention the glossiness of the teeth.
  • Patent Document 3 Japanese Unexamined Patent Publication No.
  • the oral composition has a degree of pregelatinization of 90% or less, an average particle size of 1 to 5 ⁇ , and does not substantially contain particles of 10 ⁇ or more. It has been proposed that the addition of alumina anhydride can impart gloss to the tooth surface even when an abrasive having high polishing power is used in combination.
  • the present invention has been made in view of the above circumstances, and an object of the present invention is to provide a dentifrice composition which is excellent in the stain removing effect and the gloss-imparting effect of teeth and has a good usability.
  • the present inventors have obtained (A) pyrophosphate, (B) aluminum oxide, and (C) alkyl sulfate among the condensed phosphates, respectively.
  • a dentifrice composition containing a specific amount the effect of removing stains from teeth and the effect of imparting luster are excellent, stain stains on teeth can be removed to impart high luster, and the feeling of stiffness in the oral cavity is felt. It has been found that it is suppressed, has good foam quality and foaming, can give a good feeling of use, and is effective for whitening teeth, and has led to the present invention.
  • the dentifrice composition by combining the components (A), (B) and (C), a gloss-imparting effect is given together with an excellent tooth stain removing effect within a specific range in the amount of each component. It was possible to impart a remarkably high glossiness to the teeth and to secure a good usability.
  • the component (A) and the component (B) in an appropriate amount in combination the coloring removing ability is improved, and a high stain removing action and a gloss-imparting action are exhibited, whereby the stain stain on the tooth surface is removed. Not only was it removed, but the glossiness was significantly increased, and the teeth could be made to shine and look even more beautiful.
  • the feeling of stiffness in the oral cavity due to the components (A) and (B) is suppressed without deterioration, and the foam quality and foaming are also improved, resulting in good use.
  • I was able to secure a feeling.
  • (D) polyoxyethylene hydrogenated castor oil in addition to the components (A), (B) and (C) the feeling of stiffness in the oral cavity is further reduced and alleviated, and the feeling of use is reduced. I was also able to increase.
  • (E) xanthan gum the foam quality and foaming could be further improved, and the detergency could be further enhanced.
  • the dentifrice composition in which the components (A), (B) and (C) of the present invention shown in Examples are blended in specific amounts is excellent in the stain removing effect and the tooth gloss-imparting effect. In addition, it had a good feeling of stiffness in the oral cavity, foam quality (a firm texture of foam), and foaming, and was excellent in usability.
  • the present invention provides the following dentifrice composition.
  • the present invention it is possible to provide a dentifrice composition which is excellent in the stain removing effect and the gloss-imparting effect of teeth, suppresses the feeling of stiffness in the oral cavity, has good foam quality and foaming, and has a good usability.
  • the dentifrice composition of the present invention not only removes stain stains on teeth but also imparts luster to make teeth shine and make them more beautiful, and is effective for tooth whitening.
  • the dentifrice composition of the present invention contains (A) pyrophosphate, (B) aluminum oxide and (C) alkyl sulfate. Further, it preferably contains (D) polyoxyethylene hydrogenated castor oil and / or (E) xanthan gum.
  • (A) Pyrophosphate when used in combination with the component (B), exerts a stain removing effect and a gloss-imparting effect on teeth.
  • the pyrophosphate an alkali metal salt such as a sodium salt of pyrophosphate can be used.
  • the blending amount of (A) pyrophosphate is preferably 0.2 to 0.8% (mass%, the same applies hereinafter) of the entire composition, and more preferably 0.4 to 0.6%. If the blending amount is less than 0.2%, the stain removing effect and the gloss-imparting effect of the teeth are weak, and if it exceeds 0.8%, the feeling of stiffness in the oral cavity becomes too strong and the usability is inferior.
  • a condensed phosphate other than (A) pyrophosphate can be further blended.
  • Specific examples thereof include sodium salts and potassium salts of linear polyphosphates such as tripolyphosphoric acid and tetrapolyphosphate, and sodium salts and potassium salts of cyclic polyphosphates such as trimetaphosphate and tetrapolyphosphate.
  • One type or two or more types can be blended.
  • the total blending amount including the blending amount of the above-mentioned component (A) is 0.2 to 0.8% of the total composition. It is preferable, more preferably 0.4 to 0.6%, and 0% without blending is preferable in terms of exhibiting the effect of the present invention.
  • Aluminum oxide exhibits a stain removing effect and a gloss-imparting effect on teeth when used in combination with the component (A).
  • the average particle size (volume standard, D50) of aluminum oxide is not particularly limited, but is preferably 1 to 10 ⁇ m, and more preferably 1 to 8 ⁇ m. Further, it may contain particles exceeding 10 ⁇ m, and when it is contained, the content is preferably 20% or less.
  • the average particle size is a value measured by a laser diffraction method.
  • the blending amount of (B) aluminum oxide is 0.5 to 2.5%, preferably 1.9 to 2.1% of the total composition.
  • the blending amount is less than 0.5%, the stain removing effect and the gloss-imparting effect of the teeth are weak, and if it exceeds 2.5%, the polishing power is too strong, and the oral cavity feels stiff and feels good to use. Inferior.
  • (A) / (B) indicating the quantitative ratio of the component (A) to the component (B) can be 0.08 to 1.6 as a mass ratio, but is preferably 0.1 to 1. , More preferably 0.2 to 0.4.
  • the stain removing effect and the gloss-imparting effect of the teeth are more excellent, and the feeling of stiffness in the oral cavity is further suppressed.
  • Alkyl sulfate improves foam quality and foaming, imparts a sufficient amount of foam with a firm texture, thereby exerts an effect of enhancing detergency and an effect of improving usability.
  • alkyl sulfate an alkyl sulfate having 10 to 18 carbon atoms, particularly 12 to 16 is preferable, and examples thereof include lauryl sulfate and myristyl sulfate.
  • the salt is preferably an alkali metal salt, particularly preferably a sodium salt, and specific examples thereof include sodium lauryl sulfate and sodium myristyl sulfate.
  • the blending amount of the (C) alkyl sulfate is 1 to 1.8%, preferably 1.2 to 1.4% of the total composition. If the blending amount is less than 1%, the effect of improving foam quality and foaming is weak, and if it exceeds 1.8%, the feeling of stiffness in the oral cavity derived from the components (A) and (B) deteriorates, and the feeling of use becomes worse. Inferior.
  • the average number of moles (EO) of ethylene oxide added to the polyoxyethylene hydrogenated castor oil is preferably 10 to 60, more preferably 10 to 20.
  • the blending amount of the polyoxyethylene hydrogenated castor oil (D) is preferably 0.3 to 5%, more preferably 0.2 to 3% of the whole composition. When the blending amount is within the above range, the effect of reducing the feeling of stiffness in the oral cavity is sufficiently obtained, and the foam quality and foaming are maintained. If the blending amount of the component (D) exceeds 5%, the foam quality and foaming may deteriorate.
  • (E) xanthan gum it is preferable to further add (E) xanthan gum to the dentifrice composition of the present invention.
  • the blending amount of (E) xanthan gum is preferably 1.2 to 1.6%, more preferably 1.5 to 1.6% of the total composition. When the blending amount is within the above range, the foam quality becomes even more firm, the foam quality and foaming are further improved, and the detergency is enhanced.
  • the dentifrice composition of the present invention can be prepared in the form of paste, gel, liquid, etc. in the form of dentifrice, liquid dentifrice, dentifrice, etc., and among them, dentifrice is preferable.
  • other known components usually used in the dentifrice composition can be blended, if necessary, as long as the effects of the present invention are not impaired.
  • the optional ingredients that can be blended include abrasives, binders, surfactants, wetting agents, sweetening agents, fragrances, pH adjusters, preservatives, colorants, active ingredients and the like.
  • a usual method can be adopted, and these compounding ingredients and water can be mixed and prepared.
  • the polishing agent is (B) a polishing agent other than aluminum oxide, for example, a calcium phosphate-based compound such as a second calcium phosphate dihydrate salt or an anhydride, a first calcium phosphate, a third calcium phosphate, a calcium pyrophosphate; Silica-based abrasives such as sex silica, aluminosilicate, zirconosilicate, titanium-binding silica; calcium carbonate-based abrasives such as calcium carbonate; calcium hydroxide, aluminum hydroxide, tertiary magnesium phosphate, magnesium carbonate, calcium sulfate , Bentnite, hydroxyapatite, and one or more of these can be blended.
  • a calcium phosphate-based compound such as a second calcium phosphate dihydrate salt or an anhydride, a first calcium phosphate, a third calcium phosphate, a calcium pyrophosphate
  • Silica-based abrasives such as sex si
  • granules such as silica granules and zeolite granules, which are insoluble powders, can be blended.
  • the volume average particle size (median diameter d50) of the granules is preferably 50 to 500 ⁇ m.
  • the volume average particle size is a measured value by a particle size distribution measuring device (Microtrak particle size distribution meter manufactured by Nikkiso Co., Ltd., dispersion medium; water).
  • the average disintegration strength of the granules is preferably 10 to 200 g / piece.
  • the average decay strength is the measured value of the automatic breaking strength of 30 granules by a leometer (Sun Leometer CR-200D, manufactured by Sun Kagaku Co., Ltd.) (when one granule is compressed at a rate of 10 mm / min). It is the average value of the measured value of the load when the granules disintegrate.
  • a leometer Sun Leometer CR-200D, manufactured by Sun Kagaku Co., Ltd.
  • silica granules wet gel method silica and precipitation method silica are preferably used, and the primary particle size is preferably about 3 to 15 nm, preferably 4 to 10 nm.
  • a method of classifying silica gel granules having an average particle size of 50 to 500 ⁇ m by washing and drying a mass of silica gel whose primary particle size has been grown to about 4 to 10 nm by a gel method and then pulverizing the silica gel hydrosol can be prepared by spraying them in the air and gelling them, or by a precipitation method to agglomerate the granules while suppressing the growth of the primary particles and then to grow the primary particle size to about 4 to 10 nm.
  • Known and these methods can be used to prepare silica gel granules.
  • colored granules can also be used.
  • the blending amount of these arbitrary abrasives is preferably 0.1 to 30%, particularly 0.1 to 20% of the entire composition.
  • the binder is a binder other than (E) xanthane gum, for example, sodium carboxymethyl cellulose, sodium polyacrylate, sodium alginate, polyvinylpyrrolidone, carrageenan, methyl cellulose, hydroxyethyl cellulose, tragant gum, karaya gum, arabia gum, locust bean gum, polyvinyl.
  • Organic binders such as alcohol, carboxyvinyl polymer, carbopol, bee gum, and propylene glycol alginate, and inorganic binders such as thickening silica and aluminum silicate can be blended. These can be used in one kind or two or more kinds. When any of these binders is blended, the total blending amount of the blending amount and the blending amount of the component (E) described above may be 1.2 to 1.6% of the total composition. It is preferable, more preferably 1.4 to 1.6%.
  • surfactant in addition to (C) alkyl sulfate and (D) polyoxyethylene hydrogenated castor oil, other anionic surfactants, nonionic surfactants, and amphoteric surfactants can be blended. , These can be used alone or in combination of two or more.
  • Any anionic surfactants include, for example, N-acyl taurates such as ⁇ -olefin sulfonate, hydrogenated coconut fatty acid monoglyceride monosulfate, lauryl sulfoacetate, N-methyl-N-acyl taurine salt, lauroyl.
  • N-acyl taurates such as ⁇ -olefin sulfonate, hydrogenated coconut fatty acid monoglyceride monosulfate, lauryl sulfoacetate, N-methyl-N-acyl taurine salt, lauroyl.
  • acyl sarcosine salts such as sarcosin sodium
  • acyl amino acid salts such as N-acyl-L-glutamate.
  • alkali metal salts such as sodium and potassium of ⁇ -olefin sulfonic acid having 14 to 16 carbon atoms can be used, and among them, the ⁇ -olefin sulfonic acid salt having 14 carbon atoms, particularly sodium.
  • a salt (generic name; sodium tetradecene sulfonate) is preferred.
  • Commercially available products that can be used for oral preparations can be obtained for these, and for example, the trade name “K Liporan PJ-400CJ” manufactured by Lion Specialty Chemicals Co., Ltd. can be used.
  • the total blending amount including the blending amount of the above-mentioned component (C) is preferably 1 to 1.8% of the total composition. , More preferably 1.2 to 1.4%.
  • Any nonionic surfactant may be, for example, a sucrose fatty acid ester such as maltose fatty acid ester; a sugar alcohol fatty acid ester such as maltitol fatty acid ester, lactitol fatty acid ester; Oxyethylene sorbitan fatty acid ester; fatty acid diethanolamide such as lauric acid mono or diethanolamide; sorbitan fatty acid ester; polyoxyethylene polyoxypropylene copolymer; polyoxyethylene polyoxypropylene fatty acid ester.
  • the total blending amount including the blending amount of the above-mentioned component (D) is preferably 0.3 to 5% of the total composition. , More preferably 0.2 to 3%, and may be 0% without blending.
  • Amphoteric tensides are fatty acid amidopropyl betaine such as cocamidopropyl betaine; alkyl betaine such as lauryldimethylaminoacetic acid betaine; imidazoline type amphoteric tenside such as coconut oil fatty acid imidazolium betaine; amino acid type amphoteric tenside such as sodium lauroyl glutamate. Examples include surfactants.
  • the total blending amount of the surfactant (total blending amount calculated by adding the blending amounts of the component (C) and the component (D)) is preferably 1.3 to 2.3% of the total composition, more preferably. It is preferably 1.4 to 1.7%.
  • wetting agent examples include sugar alcohols such as sorbitol and xylit, glycerin, propylene glycol, and polyhydric alcohols such as polyethylene glycol having an average molecular weight of 160 to 400 (average molecular weight described in the standard for raw materials for non-pharmaceutical products 2006). These blending amounts are usually 5-50%, particularly 20-45% of the total composition.
  • sweetener examples include sodium saccharin, steviaside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perraltin, glycyrrhizin, thaumatin, aspalathylphenylalanine methyl ester and the like.
  • the fragrances are known fragrances such as menthol, anator, carboxylic, eugenol, limonene, n-decyl alcohol, citronellol, ⁇ -terepineol, citronellyl acetate, cineole, linalol, ethyllinalol, varnish, timole, sparemint oil, peppermint oil, Lemon oil, orange oil, sage oil, rosemary oil, katsura oil, pimento oil, katsura leaf oil, perilla oil, winter green oil, choji oil, eucalyptus oil and the like can be mentioned.
  • Examples of the pH adjuster include organic acids such as citric acid and lactic acid and salts thereof; and inorganic compounds such as hydrochloric acid, sodium hydroxide, sodium hydrogencarbonate, potassium hydroxide, disodium hydrogen phosphate and sodium dihydrogen phosphate.
  • Examples of the preservative include paraoxybenzoic acid ester, sodium benzoate and the like.
  • Examples of the colorant include Blue No. 1, Yellow No. 4, Titanium Dioxide and the like.
  • the active ingredient is a fluorine-containing compound such as sodium fluoride and sodium monofluorophosphate; enzymes such as dextranase, amylase, protease and mutanase; tranexamic acid, epsilon aminocaproic acid, aluminum chlorhydroxyalantin, azulene and glycyrrhizinate, Anti-inflammatory agents such as glycyrrhetinate; cell activators such as sodium chloride and vitamins; bactericides such as isopropylmethylphenol, triclosan, cetylpyridinium chloride, benzalkonium chloride, hinokithiol, lysoteam chloride; copper chlorophyll, copper gluconate Water-soluble copper compounds such as; Toothstone preventive agents such as zeolite; Blood circulation promoters such as Vitamin E; Amino acids such as alanine, glycine and proline.
  • the blending amount of the active ingredient can be an effective amount within
  • inorganic compounds such as mica titanium and bentonite; cellulose-based organic powders such as crystalline cellulose; natural polymer compounds such as agar, gelatin, starch and glucomannan; polyvinyl acetate, acrylic resin and polyurethane, Synthetic polymer compounds such as polyester, polyvinyl chloride, nylon powder, polyethylene powder, or copolymers thereof; waxes such as carnauba wax, rosin, rice wax, microcrystallin wax, beeswax, paraffin wax; cetanol, stearyl alcohol, etc. Higher alcohols; polyisobutylene, polybutadiene, silicone, natural rubber and the like can be blended within a range that does not interfere with the effects of the present invention.
  • Toothpaste compositions (dentifrices) having the compositions shown in Tables 1 to 3 were prepared by a conventional method and evaluated by the following methods. The results are also shown in the table.
  • HAP Stain-Adhered Hydroxyapatite Pellets
  • the tannin extract is 50 g of green tea (manufactured by ITO EN Co., Ltd., trade name: green tea with smooth green tea) and black tea (manufactured by Uniriva Japan Co., Ltd., Brisk) in 1,200 mL of boiled ion-exchanged water. 5 bags of tea bag and 12 g of instant coffee (manufactured by Nestle Japan Co., Ltd., trade name: Nescafe) were added, left overnight, and Japanese tea and black tea were removed by filtration to prepare the tea.
  • the color difference (L * value) on the surface of the prepared stain-attached HAP was measured using a spectroscopic colorimeter (manufactured by Nippon Denshoku Kogyo Co., Ltd., model: SE-2000), and this was measured as the L * value before treatment. And said.
  • the glossiness (glossiness before treatment) of the surface of the prepared stain-attached HAP was measured using a glossiness meter (Gross Meter VG2000 manufactured by Nippon Denshoku Kogyo Co., Ltd.). was set to the ⁇ Gs0 value before the treatment.
  • the stain-attached HAP prepared by the above method was used with the dentifrice composition of the test sample in artificial saliva (50 mM KCl, 1 mM CaCl 2 , 0.1 mM MgCl 2 , 1 mM KH 2 PO 4 , pH 7.0). After immersing in a 3-fold diluted sample solution for 10 minutes, the dentifrice composition adhering to the HAP surface was wiped off with paper, washed in running water, and then the L * value on the HAP surface was measured. L * value. The difference ( ⁇ L *) in the L * values before and after the treatment was obtained, and the stain removing effect of the teeth was determined according to the following criteria. Judgment criteria ⁇ : ⁇ L *> 10 ⁇ : 10 ⁇ ⁇ L *> 3 ⁇ : 3 ⁇ ⁇ L *
  • ⁇ Evaluation method of usability> The usability was evaluated by 4 subjects. 1 g of the dentifrice composition of the test sample was placed on a toothbrush (Clinica Advantage toothbrush, 4-row compact, usually manufactured by Lion Corporation), the dentifrice was brushed for 3 minutes, and then the mouth was washed once with 10 mL of water. Immediately after use, the feeling of stiffness in the oral cavity (no feeling of stiffness in the oral cavity), the quality of foam (the firm texture of foam), and the foaming (the amount of foaming) were judged according to the following criteria.
  • the composition of the fragrance A (fragrance composition A) used is as shown in Tables 4 to 12.
  • the effects of the present invention were also obtained by using the fragrance compositions B to T having the compositions shown in Tables 4 to 12 instead of the fragrance A.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition de dentifrice qui excelle dans l'effet de l'élimination de taches sur les dents et dans un effet conférant un éclat, supprime une sensation rugueuse à l'intérieur de la cavité buccale, présente une qualité de mousse et un moussage excellents, et présente une excellente sensation d'utilisation.　La composition de dentifrice contient 0,2 à 0,8 % en masse d'un pyrophosphate (A), 0,5 à 2,5 % en masse d'oxyde d'aluminium (B), et 1 à 1,8 % en masse d'un sulfate d'alkyle (C).
PCT/JP2021/033524 2020-09-17 2021-09-13 Composition de dentifrice WO2022059642A1 (fr)

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Application Number Priority Date Filing Date Title
JP2022550546A JPWO2022059642A1 (fr) 2020-09-17 2021-09-13

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JP2020-156103 2020-09-17
JP2020156103 2020-09-17

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WO2022059642A1 true WO2022059642A1 (fr) 2022-03-24

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5857312A (ja) * 1981-10-01 1983-04-05 Lion Corp 口腔用組成物
JP2004500377A (ja) * 2000-01-27 2004-01-08 ザ、プロクター、エンド、ギャンブル、カンパニー 改良型低コスト歯磨き剤組成物
WO2007069429A1 (fr) * 2005-12-15 2007-06-21 Lion Corporation Composition de dentifrice
JP2007161657A (ja) * 2005-12-15 2007-06-28 Lion Corp 歯磨組成物
JP2007308429A (ja) * 2006-05-19 2007-11-29 Lion Corp 歯牙美白用組成物
JP2009521500A (ja) * 2005-12-21 2009-06-04 コルゲート・パーモリブ・カンパニー 清浄及び／又は光沢組成物とその使用の方法
JP2010265310A (ja) * 2003-09-26 2010-11-25 Tahitian Noni Internatl Inc モリンダ・シトリフォリアベースの口腔ケア組成物および方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5857312A (ja) * 1981-10-01 1983-04-05 Lion Corp 口腔用組成物
JP2004500377A (ja) * 2000-01-27 2004-01-08 ザ、プロクター、エンド、ギャンブル、カンパニー 改良型低コスト歯磨き剤組成物
JP2010265310A (ja) * 2003-09-26 2010-11-25 Tahitian Noni Internatl Inc モリンダ・シトリフォリアベースの口腔ケア組成物および方法
WO2007069429A1 (fr) * 2005-12-15 2007-06-21 Lion Corporation Composition de dentifrice
JP2007161657A (ja) * 2005-12-15 2007-06-28 Lion Corp 歯磨組成物
JP2009521500A (ja) * 2005-12-21 2009-06-04 コルゲート・パーモリブ・カンパニー 清浄及び／又は光沢組成物とその使用の方法
JP2007308429A (ja) * 2006-05-19 2007-11-29 Lion Corp 歯牙美白用組成物

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