WO2021195683A1 - Dispositif de neutralisation d'agents pathogènes inertes et unicellulaires - Google Patents

Dispositif de neutralisation d'agents pathogènes inertes et unicellulaires Download PDF

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Publication number
WO2021195683A1
WO2021195683A1 PCT/AT2021/060112 AT2021060112W WO2021195683A1 WO 2021195683 A1 WO2021195683 A1 WO 2021195683A1 AT 2021060112 W AT2021060112 W AT 2021060112W WO 2021195683 A1 WO2021195683 A1 WO 2021195683A1
Authority
WO
WIPO (PCT)
Prior art keywords
filter
positively charged
pathogens
pores
charged ions
Prior art date
Application number
PCT/AT2021/060112
Other languages
German (de)
English (en)
Inventor
Alireza ESLAMIAN
Martin SCHIFKO
Original Assignee
Ess Holding Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ess Holding Gmbh filed Critical Ess Holding Gmbh
Publication of WO2021195683A1 publication Critical patent/WO2021195683A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/42—Auxiliary equipment or operation thereof
    • B01D46/50—Means for discharging electrostatic potential
    • A—HUMAN NECESSITIES
    • A62—LIFE-SAVING; FIRE-FIGHTING
    • A62B—DEVICES, APPARATUS OR METHODS FOR LIFE-SAVING
    • A62B23/00—Filters for breathing-protection purposes
    • A62B23/02—Filters for breathing-protection purposes for respirators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D37/00—Processes of filtration
    • B01D37/02—Precoating the filter medium; Addition of filter aids to the liquid being filtered
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D13/00—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches
    • A41D13/05—Professional, industrial or sporting protective garments, e.g. surgeons' gowns or garments protecting against blows or punches protecting only a particular body part
    • A41D13/11—Protective face masks, e.g. for surgical use, or for use in foul atmospheres
    • A41D13/1192—Protective face masks, e.g. for surgical use, or for use in foul atmospheres with antimicrobial agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2209/00—Aspects relating to disinfection, sterilisation or deodorisation of air
    • A61L2209/10—Apparatus features
    • A61L2209/14—Filtering means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/16—Disinfection, sterilisation or deodorisation of air using physical phenomena
    • A61L9/22—Ionisation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/04—Additives and treatments of the filtering material
    • B01D2239/0414—Surface modifiers, e.g. comprising ion exchange groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/04—Additives and treatments of the filtering material
    • B01D2239/0414—Surface modifiers, e.g. comprising ion exchange groups
    • B01D2239/0421—Rendering the filter material hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/04—Additives and treatments of the filtering material
    • B01D2239/0435—Electret
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/04—Additives and treatments of the filtering material
    • B01D2239/0442—Antimicrobial, antibacterial, antifungal additives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2279/00—Filters adapted for separating dispersed particles from gases or vapours specially modified for specific uses
    • B01D2279/65—Filters adapted for separating dispersed particles from gases or vapours specially modified for specific uses for the sterilisation of air
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/0027—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours with additional separating or treating functions
    • B01D46/0028—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours with additional separating or treating functions provided with antibacterial or antifungal means

Definitions

  • the invention relates to a device for neutralizing inanimate and unicellular pathogens from an air stream with a filter which has open, continuous pores, the inner walls of which are coated at least in sections with positively charged ions.
  • porous filters with open pores, for example made of a multilayer composite of cellulose, polyester and polypropylene.
  • the surface of these filters is coated with positively charged ions in order to bind the negatively charged groups of the pathogen envelopes and thereby neutralize the pathogens themselves.
  • the protective effect is created by immobilizing the pathogens on the filter surface.
  • the disadvantage of such filters is that not all pathogens can be bound to the filter surface and thus there is still a reduced risk of infection and thus disease.
  • the invention is therefore based on the object of reducing the risk of disease in the long term, a device of the type described above, in particular when it is used as mouth and nose protection.
  • the invention achieves the stated problem in that a first part of the positive ions is bound to linkers which are attached to the inner walls of the pores via a water-soluble binding element.
  • the pathogens bound to the positively charged ions do not remain on the surface of the filter, but can leave it after they have been at least partially neutralized by binding to the positively charged ion so that an immune response to the neutralized pathogen residues is possible.
  • neutralization is understood to mean damaging the outer shell of the pathogen or impairing the function of at least some glycoproteins, which can also take place due to the chemical processes after leaving the filter. Because of the humidity available in the air flow, such as the air we breathe, the water-soluble binding elements are dissolved, so that the remaining linker is released together with the positively charged ion and the pathogen bound to it. However, this effect does not occur immediately, but rather with a time delay and gradually with an increase in the air humidity in the filter, so that the amount of neutralized pathogen residues released remains low.
  • the heating by the air flow such as breathing air, can promote the loosening of the binding element.
  • starch molecules can be used as a water-soluble binding element. Suitable linkers between starch and the positively charged ions are well known to the person skilled in the art, depending on the type of ions.
  • the pores in the area of the water-soluble binding elements can have a hydrophilic coating.
  • the air humidity bound in the air flow can thus settle more evenly on the inner walls of the pores, so that a selective loosening of only a few binding elements can be avoided in favor of a uniform loosening behavior.
  • pathogens can be prevented from collecting in forming droplets and in this way a disease can be prevented. So that immunization can take place with a reduced risk of an outbreak of disease even with a high concentration of pathogens in the air stream, it is proposed according to the invention that a second part of the positively charged ions be attached to the inner walls of the pores in a water-insoluble manner.
  • the filter be arranged between two electrodes for applying an alternating electric field.
  • the energy introduced by the alternating field not only is a chemical binding reaction facilitated, but a reconfiguration of ligand and / or receptor as binding partner required for binding is also energetically favored.
  • the filter can form a filter plate through which the air stream flows parallel to a largest plate surface.
  • the pathogens remain in the pores of the filter for a longer period of time, so that a ne better neutralizing effect is made possible.
  • the moisture concentration within the filter increases gradually from the inlet of the air flow to the outlet, so that successive areas of the filter in the direction of the air flow release the neutralized pathogens one after the other and thus keep the total number of released pathogens constantly low over a longer period of time can be.
  • Certain pathogens can be filtered out of the air stream in a more targeted manner by binding ligand molecules to the ions.
  • the positive charge of the ion is used to create a bond with the ligand molecule, so that the latter forms a bond complex with the ion.
  • the ligand molecule comprises a binding site to a receptor of a specific pathogen. This allows specific pathogens to be filtered out of the air flow, while other components of the air flow that might also react with the charge of the positive ion can pass through the filter.
  • the binding of the ion to the ligand molecule can take place, for example, via negatively charged amino acids on the outside of the ligand molecules.
  • the ligand molecules can also be antibodies, for example, which can be particularly easily bound to iron or selenium ions.
  • a ligand molecule can also be bound to several ions as long as its binding site for binding the pathogen remains free.
  • the ligand molecules can include mannose-binding lectins.
  • Mannose-binding lectins play a role in many immune processes by binding pathogens such as viruses.
  • the mannose-binding lectins can, for example, be bound to the positive ion directly via negatively charged amino acids on their outside, or indirectly via functionalized antibodies that establish a bond between the ion and mannose-binding lectin.
  • point mutations of amino acids can generate MBL mutations that can be more easily bound directly to the ion.
  • An indirect bond can be established, for example, by binding anti-MBL immunoglobulins to iron ions by means of ferritin.
  • Fig. 1 is a schematic section through a pore of the Fil age according to the invention with unbound pathogens
  • Fig. 2 shows a section corresponding to Fig. 1 with partially bound Patho genes
  • Fig. 3 shows Figs. 1 and 2 corresponding section with partially loosened bin elements
  • Fig. 4 is a perspective view of a device according to the invention in egg nem larger scale
  • Fig. 5 shows a section corresponding to FIG. 3 with partially loosened Bindeele elements and a ligand molecule bound to the ion.
  • a device for neutralizing inanimate and unicellular pathogens 1 has a filter 2 through which several open pores 3 pass through. These pores 3 are provided on their inner walls 4 with positively charged ions 5, some of which are water-soluble, attached to the inner walls 4, and positive ions 6, some of which are insoluble in water, attached to the inner walls.
  • the positively charged ions 5 attached in a water-soluble manner are bound to linkers 7, which in turn are attached to the inner walls 4 of the pores 3 via a water-soluble binding element 8.
  • the positively charged ions 5, 6 can, for example, be iron ions, while the binding element 8 can be a starch molecule.
  • the linker 7 can for example consist of a functionalized polyethylene glycol chain which is coupled either directly or indirectly, for example via antibodies, to the binding element 8 and / or the positively charged ions 5. If an air stream flows through the filter 2 according to the invention, the pathogens 1 floating in the air stream pass through the pores 3 of the filter 2, as can be seen from FIG. 1.
  • the filter 2 is arranged between two electrodes 9, 10, which by applying an alternating voltage in the space between the electrodes 9, 10 and thus also within the pores 3 of the filter 2 generate an electromagnetic alternating field.
  • the Fil ter 2 can form a filter plate that is traversed by the air flow parallel to a largest plate surface, for example in the flow direction 11 shown.
  • ligand molecules 12 can be bound to the positively charged ions 5, 6 in order to selectively filter certain pathogens 1 from the air stream.
  • the charge of the positively charged ions 5, 6 is used in this case to bind the ligand molecules 12, which in turn enter into a selective bond with certain pathogens 1, while other particles that are not recognized by the ligand molecules 12 are simpler Filters can pass.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Business, Economics & Management (AREA)
  • Emergency Management (AREA)
  • Disinfection, Sterilisation Or Deodorisation Of Air (AREA)

Abstract

L'invention concerne un dispositif de neutralisation d'agents pathogènes inertes et unicellulaires (1) dans un flux d'air, comprenant un filtre (2) qui présente des pores ouverts continus (3) dont les parois internes (4) sont revêtues, au moins en partie, d'ions chargés positivement (5). Afin de concevoir un dispositif du type décrit ci-dessus de telle sorte que, en particulier lorsqu'il est utilisé en tant que protection de la bouche et du nez, le risque d'infection puisse être réduit à long terme, il est proposé qu'une première partie des ions chargés positivement (5) soie liée à un coupleur (7) qui est fixé aux parois internes (4) des pores (3) au moyen d'un élément de liaison soluble dans l'eau (8).
PCT/AT2021/060112 2020-04-01 2021-04-01 Dispositif de neutralisation d'agents pathogènes inertes et unicellulaires WO2021195683A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ATA50276/2020A AT522961B1 (de) 2020-04-01 2020-04-01 Elektrofilter
ATA50276/2020 2020-04-01

Publications (1)

Publication Number Publication Date
WO2021195683A1 true WO2021195683A1 (fr) 2021-10-07

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ID=75497758

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AT2021/060112 WO2021195683A1 (fr) 2020-04-01 2021-04-01 Dispositif de neutralisation d'agents pathogènes inertes et unicellulaires

Country Status (2)

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AT (1) AT522961B1 (fr)
WO (1) WO2021195683A1 (fr)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999032707A1 (fr) * 1997-12-22 1999-07-01 Retroscreen Limited Matieres pour la capture de virus
US20060088926A1 (en) * 2003-03-28 2006-04-27 Daikin Industries, Ltd. Method of removing hazardous substance, and hazardous substance removing material using the same such as air cleaning filter, mask and wipping sheet, and method of storing the same
WO2008120005A1 (fr) * 2007-04-03 2008-10-09 Medi-Immune Ltd Dispositif protecteur
WO2010138426A1 (fr) * 2009-05-29 2010-12-02 Filligent Limited Composition destinée à être utilisée dans la diminution de la transmission de pathogènes humains
WO2012049551A1 (fr) * 2010-10-11 2012-04-19 Labio Test Srl Filtre et son procédé de fabrication
WO2012130117A1 (fr) * 2011-04-01 2012-10-04 Filligent Limited Structure de masque destinée à être utilisée pour réduire la transmission des pathogènes humains
WO2015015671A1 (fr) * 2013-08-01 2015-02-05 株式会社Ｎｂｃメッシュテック Dispositif de purification d'air

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08510923A (ja) * 1992-06-30 1996-11-19 アメリカ合衆国 ウイルス防御バリア材の生産方法
EP1441831A4 (fr) * 2001-10-19 2005-10-26 Innovative Constr & Build Mat Materiau de filtration d'air anti-pathogenes et dispositifs de traitement d'air offrant une protection contre les microorganismes infectieux en suspension dans l'air
US20100282083A1 (en) * 2007-01-03 2010-11-11 John Edwards Disinfecting air filter
KR101642608B1 (ko) * 2014-12-26 2016-07-25 도레이케미칼 주식회사 바이러스 및 박테리아 필터용 여재 및 이의 제조방법
KR101642609B1 (ko) * 2014-12-29 2016-07-25 도레이케미칼 주식회사 정수기용 카트리지 필터, 이의 제조방법 및 이를 포함하는 정수기용 카트리지
CN109562197B (zh) * 2016-08-19 2021-11-16 崔孝直 用于在气溶胶中使病原体失活的材料、装置及方法与用于制造其的方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999032707A1 (fr) * 1997-12-22 1999-07-01 Retroscreen Limited Matieres pour la capture de virus
US20060088926A1 (en) * 2003-03-28 2006-04-27 Daikin Industries, Ltd. Method of removing hazardous substance, and hazardous substance removing material using the same such as air cleaning filter, mask and wipping sheet, and method of storing the same
WO2008120005A1 (fr) * 2007-04-03 2008-10-09 Medi-Immune Ltd Dispositif protecteur
WO2010138426A1 (fr) * 2009-05-29 2010-12-02 Filligent Limited Composition destinée à être utilisée dans la diminution de la transmission de pathogènes humains
WO2012049551A1 (fr) * 2010-10-11 2012-04-19 Labio Test Srl Filtre et son procédé de fabrication
WO2012130117A1 (fr) * 2011-04-01 2012-10-04 Filligent Limited Structure de masque destinée à être utilisée pour réduire la transmission des pathogènes humains
WO2015015671A1 (fr) * 2013-08-01 2015-02-05 株式会社Ｎｂｃメッシュテック Dispositif de purification d'air

Also Published As

Publication number Publication date
AT522961B1 (de) 2021-04-15
AT522961A4 (de) 2021-04-15

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