WO2021092439A1 - Methods of treating depressive disorders - Google Patents

Methods of treating depressive disorders Download PDF

Info

Publication number
WO2021092439A1
WO2021092439A1 PCT/US2020/059481 US2020059481W WO2021092439A1 WO 2021092439 A1 WO2021092439 A1 WO 2021092439A1 US 2020059481 W US2020059481 W US 2020059481W WO 2021092439 A1 WO2021092439 A1 WO 2021092439A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
human
administered
dose
disorder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2020/059481
Other languages
English (en)
French (fr)
Inventor
Cynthia Louise HARDEN
Gregory N. Beatch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xenon Pharmaceuticals Inc
Original Assignee
Xenon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to MX2022005490A priority Critical patent/MX2022005490A/es
Priority to PH1/2022/551110A priority patent/PH12022551110A1/en
Priority to PE2022000702A priority patent/PE20221766A1/es
Priority to EP20816351.9A priority patent/EP4054580A1/en
Priority to BR112022008580A priority patent/BR112022008580A2/pt
Priority to JP2022524695A priority patent/JP2022553569A/ja
Priority to NZ787838A priority patent/NZ787838B2/en
Priority to CA3155812A priority patent/CA3155812A1/en
Priority to KR1020227017725A priority patent/KR20220098746A/ko
Priority to CR20220250A priority patent/CR20220250A/es
Priority to CN202080077815.3A priority patent/CN114667146A/zh
Priority to AU2020380961A priority patent/AU2020380961A1/en
Application filed by Xenon Pharmaceuticals Inc filed Critical Xenon Pharmaceuticals Inc
Priority to MA56607A priority patent/MA56607A1/fr
Publication of WO2021092439A1 publication Critical patent/WO2021092439A1/en
Priority to IL292678A priority patent/IL292678A/en
Anticipated expiration legal-status Critical
Priority to CONC2022/0008001A priority patent/CO2022008001A2/es
Priority to JP2025155966A priority patent/JP2026001049A/ja
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Definitions

  • FIG. 2 shows results of the mouse forced swim test including a graphical representation of the average time immobile (2-6 min)(sec, y-axis) for vehicle, 1 mg/kg Compound A, 3 mg/kg Compound A, and imipramine dosing (x-axis).
  • the therapeutically effective amount of Compound A may be orally administered to the subject, for example, between about 30 minutes prior to about 2 hours after eating a meal, most advantageously, the dosage unit of Compound A is orally administered during a meal or within 15 minutes after eating a meal.
  • “Under fasted conditions” refers to the condition of not having consumed food during the time period between from at least 4 hours prior to the oral administration of a therapeutically effective amount of Compound A to about 4 hours after administration of Compound A.
  • the present disclosure is directed to a method of treating obsessive-compulsive disorder (OCD), panic disorder, social anxiety disorder, social phobia, agoraphobia, agoraphobia with panic disorder, hypochondriasis, post-traumatic stress disorder (PTSD), treatment-resistant bipolar disorder, generalized anxiety disorder, attention- deficit/hyperactivity disorder (ADHD), bipolar I disorder, bipolar II disorder, manic disorder, cyclothymic disorder and bipolar disorder not otherwise specified, dysthymic disorder, depressive disorder not otherwise specified, minor depression, recurrent brief depressive disorder, depressive-type psychosis, impulse-control disorders, schizophrenia, schizophreniform disorder, schizoaffective disorder, Parkinson's disease, dementia, Alzheimer's disease, Huntington's disease, Tourette's syndrome, aggression, and substance use and/or abuse, or a combination thereof, comprising administering a therapeutically effective amount of Compound A to a human in need thereof.
  • OCD obsessive-compulsive disorder
  • More specific representative amounts include 0.05 mg/kg, 0.10 mg/kg, 0.20 mg/kg, 0.30 mg/kg, 0.40 mg/kg, 0.5 mg/kg, 0.6 mg/kg, 0.7 mg/kg, 0.80 mg/kg, 0.90 mg/kg, 1.0 mg/kg, 1.1 mg/kg, 1.2 mg/kg, 1.3 mg/kg, 1.4 mg/kg, 1.5 mg/kg, 1.6 mg/kg, 1.7 mg/kg, 1.8 mg/kg, 1.9 mg/kg and 2.0 mg/kg, or any range of amounts created by using two of the aforementioned amounts as endpoints.
  • the method or use includes administering (e.g., orally) 0.1-1.0 mg/kg of Compound A.
  • the method includes administering (e.g., orally) 0.2-0.5 mg/kg of Compound A.
  • the method or use includes orally administering 10 to 200 mg of Compound A per day, such as 10, 15, 20, 25, 30, 35, or 40 mg to 75, 100, 125, 150, 175, or 200 mg of Compound A per day, including 20 to 150 mg per day.
  • the oral administration includes 50, 75, 100, or 125 mg of Compound A per day, such as 100 mg per day.
  • Drug Treatment Compound A and imipramine are formulated and administered at the concentrations described in Table 2 of Example 1 above and dosed 30 min before the TST. For each experiment, at least one control group is included, handled, and tested in parallel under strictly identical experimental conditions.
  • Rats (Wistar rats for some experiments and PVG hooded rats for other experiments) are housed in pairs and allowed 2 weeks to acclimatize before surgery. They are anesthetized and mounted in a stereotaxic frame with the incisor bar set 2.7 mm below the interaural line.
  • Stainless-steel bipolar electrodes are implanted unilaterally into the ventral tegmental area (VTA) with the electrode tips separated by 0.5 mm.
  • the coordinates used are 3.2 mm anterior to the interaural line, 0.6 mm lateral from the midline and 8.2 mm ventral from the skull surface. Five stainless-steel screws and dental cement are used to anchor the electrode assembly to the skull.
  • One group of rats is subjected to CMS-1 for a period of 9 weeks, while the other group is maintained under standard laboratory conditions.
  • the learned helplessness paradigm is a depression model in which animals are exposed to unpredictable and uncontrollable stress, e.g., electroshocks, and subsequently develop coping deficits for aversive but escapable situations.
  • the protocol is described in Chourbaji, S. et al., Brain Res. Protoc. 2005, 16:70-8.
  • the shuttles before the first foot shock (initial activity), as well as the activity in-between the trials (intertrial interval activity or ITI) are recorded.
  • Total time of testing for helplessness lasts about 20-24 min, the exact time period depending on the animal’s ability to leam the paradigm and to respond properly.
  • the apparatus is thoroughly cleaned with 70% ethanol.
  • an additional cohort of animals are tested for immunization. These animals are exposed to a pre-session, identical to the learned helplessness test in the shuttle box, in which they experience a controllable shock condition. Moreover, initial activity during the pre-exposure is monitored.

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/US2020/059481 2019-11-08 2020-11-06 Methods of treating depressive disorders Ceased WO2021092439A1 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
PH1/2022/551110A PH12022551110A1 (en) 2019-11-08 2020-11-06 Methods of treating depressive disorders
PE2022000702A PE20221766A1 (es) 2019-11-08 2020-11-06 Metodos para el tratamiento de trastornos depresivos
EP20816351.9A EP4054580A1 (en) 2019-11-08 2020-11-06 Methods of treating depressive disorders
BR112022008580A BR112022008580A2 (pt) 2019-11-08 2020-11-06 Métodos para tratar transtornos depressivos
JP2022524695A JP2022553569A (ja) 2019-11-08 2020-11-06 うつ病性障害の治療方法
NZ787838A NZ787838B2 (en) 2020-11-06 Methods of treating depressive disorders
CA3155812A CA3155812A1 (en) 2019-11-08 2020-11-06 Methods of treating depressive disorders
CR20220250A CR20220250A (es) 2019-11-08 2020-11-06 Métodos para el tratamiento de trastornos depresivos
KR1020227017725A KR20220098746A (ko) 2019-11-08 2020-11-06 우울 장애 치료 방법
MX2022005490A MX2022005490A (es) 2019-11-08 2020-11-06 Metodos para el tratamiento de trastornos depresivos.
AU2020380961A AU2020380961A1 (en) 2019-11-08 2020-11-06 Methods of treating depressive disorders
CN202080077815.3A CN114667146A (zh) 2019-11-08 2020-11-06 治疗抑郁症的方法
MA56607A MA56607A1 (fr) 2019-11-08 2020-11-06 Méthodes de traitement de troubles dépressifs
IL292678A IL292678A (en) 2019-11-08 2022-05-02 Methods for treating depressive disorders
CONC2022/0008001A CO2022008001A2 (es) 2019-11-08 2022-06-06 Métodos para el tratamiento de trastornos depresivos
JP2025155966A JP2026001049A (ja) 2019-11-08 2025-09-19 うつ病性障害の治療方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962932724P 2019-11-08 2019-11-08
US62/932,724 2019-11-08

Publications (1)

Publication Number Publication Date
WO2021092439A1 true WO2021092439A1 (en) 2021-05-14

Family

ID=73643360

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2020/059481 Ceased WO2021092439A1 (en) 2019-11-08 2020-11-06 Methods of treating depressive disorders

Country Status (19)

Country Link
US (2) US12178811B2 (https=)
EP (1) EP4054580A1 (https=)
JP (2) JP2022553569A (https=)
KR (1) KR20220098746A (https=)
CN (1) CN114667146A (https=)
AU (1) AU2020380961A1 (https=)
BR (1) BR112022008580A2 (https=)
CA (1) CA3155812A1 (https=)
CL (1) CL2022001102A1 (https=)
CO (1) CO2022008001A2 (https=)
CR (1) CR20220250A (https=)
GE (2) GEP20257732B (https=)
IL (1) IL292678A (https=)
MA (1) MA56607A1 (https=)
MX (1) MX2022005490A (https=)
PE (1) PE20221766A1 (https=)
PH (1) PH12022551110A1 (https=)
TW (1) TW202128162A (https=)
WO (1) WO2021092439A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022173855A1 (en) * 2021-02-09 2022-08-18 Xenon Pharmaceuticals Inc. Voltage-gated potassium channel opener for use in treating anhedonia
EP4069226A1 (en) 2019-12-06 2022-10-12 Icahn School of Medicine at Mount Sinai Method of treatment with kcnq channel openers
US12178811B2 (en) 2019-11-08 2024-12-31 Xenon Pharmaceuticals Inc. Methods of treating depressive disorders

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220288057A1 (en) * 2021-02-09 2022-09-15 Xenon Pharmaceuticals Inc. Conjoint therapy for treating seizure disorders
US20250128055A1 (en) * 2021-10-08 2025-04-24 Albert Ludwigs Universität Freiburg Treatment of psychiatric disorders with deep brain stimulation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008024398A2 (en) * 2006-08-23 2008-02-28 Valeant Pharmaceuticals International Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators
US8993593B2 (en) 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3639385A (en) 1968-07-26 1972-02-01 Eastman Kodak Co Heterocyclic monoazo compounds from n n-diaralkyl anilines and polyester textile materials dyed therewith
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US4181803A (en) 1973-12-14 1980-01-01 Eisai Co., Ltd. Propiophenone derivatives and preparation thereof
US4326525A (en) 1980-10-14 1982-04-27 Alza Corporation Osmotic device that improves delivery properties of agent in situ
DE3337593A1 (de) 1982-10-27 1984-05-03 Degussa Ag, 6000 Frankfurt 2-amino-3-acylamino-6-benzylamino-pyridin-derivate mit antiepileptischer wirkung
ATE25078T1 (de) 1982-10-27 1987-02-15 Degussa 2-amino-3-acylamino-6-benzylamino-pyridinderivate mit anti-epileptischer wirkung.
DE3665538D1 (en) 1985-01-23 1989-10-19 Asta Pharma Ag Synergistic combination of flupirtin and non-steroidal anti-phlogistics
EP0193056B1 (de) 1985-02-23 1989-06-07 ASTA Pharma Aktiengesellschaft Kombination von Flupirtin und anticholinergisch wirkenden Spasmolytika
DE3604575A1 (de) 1985-02-23 1986-08-28 Degussa Ag, 6000 Frankfurt Kombination von flupirtin und anticholinergisch wirkenden spasmolytika
JP2583067B2 (ja) 1987-08-04 1997-02-19 住友化学工業株式会社 モノアゾ化合物およびそれを用いて疎水性繊維材料を染色または捺染する方法
GB8800199D0 (en) 1988-01-06 1988-02-10 Beecham Group Plc Pharmaceutical preparation
MC2029A1 (fr) 1988-05-16 1990-04-25 Asta Pharma Ag (n-heterocyclyl)-3 diamino-2,6 pyridines substituees et leurs n-oxydes,preparation de ces composes et leur application comme medicaments
US5629307A (en) 1989-10-20 1997-05-13 Olney; John W. Use of ibogaine in reducing excitotoxic brain damage
US6004945A (en) 1990-05-10 1999-12-21 Fukunaga; Atsuo F. Use of adenosine compounds to relieve pain
IN172468B (https=) 1990-07-14 1993-08-14 Asta Medica Ag
US5643921A (en) 1990-09-26 1997-07-01 E.R. Squibb & Sons, Inc. Cardiopulmonary bypass and organ transplant using a potassium channel activator
US5234947A (en) 1991-11-07 1993-08-10 New York University Potassium channel activating compounds and methods of use thereof
DE4200259A1 (de) 1992-01-08 1993-07-15 Asta Medica Ag Neue 1,2,4-triaminobenzol-derivate und verfahren zu deren herstellung
US5262419A (en) 1992-06-11 1993-11-16 E. R. Squibb & Sons, Inc. Method for the prophylaxis and/or treatment of ulcerative gastrointestinal conditions using a potassium channel activator
CA2115792C (en) 1993-03-05 2005-11-01 David J. Mayer Method for the treatment of pain
US5428039A (en) 1994-02-20 1995-06-27 The Center For Innovative Technology Method for electively achieving reversible hyperpolarized cardiac arrest
JP4097285B2 (ja) 1994-09-22 2008-06-11 リチャード・アラン・スミス 種々の頑固な疾患の治療のための医薬の製造に有用な組成物
US5679706A (en) 1994-09-30 1997-10-21 Bristol-Myers Squibb Company Combination of a potassium channel activator and an antiarrhythmic agent
WO1996019233A2 (en) 1994-12-12 1996-06-27 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain, inflammation and spasm
DE19539861A1 (de) 1995-10-26 1997-04-30 Asta Medica Ag Verwendung von 4-Amino-4-(4-fluorbenzylamino)-1-ethoxy-carbonylaminobenzen zur Prophylaxe und Behandlung der Folgen der akuten und chronischen zerebralen Minderdurchblutung sowie neurodegenerativer Erkrankungen
DE19701694A1 (de) 1997-01-20 1998-07-23 Asta Medica Ag Neue Modifikationen des 2-Amino-4-(4-fluorbenzylamino)-l-ethoxycarbonyl-aminobenzen sowie Verfahren zu ihrer Herstellung
US5760007A (en) 1997-07-16 1998-06-02 Ortho Pharmaceutical Corporation Anticonvulsant derivatives useful in treating neuropathic pain
AU8561298A (en) 1997-08-08 1999-03-01 Chugai Seiyaku Kabushiki Kaisha Remedies for complications of diabetes
US6265417B1 (en) 1997-12-18 2001-07-24 Abbott Laboratories Potassium channel openers
US6593335B1 (en) 1997-12-18 2003-07-15 Abbott Laboratories Potassium channel openers
US6211171B1 (en) 1998-05-19 2001-04-03 Dalhousie University Use of antidepressants for local analgesia
JP3441970B2 (ja) 1998-06-30 2003-09-02 株式会社サミー 豆腐の製造方法及び製造装置
BR9916162A (pt) 1998-12-14 2001-09-04 Cellegy Pharma Inc Composição e método para o tratamento de um distúrbio anorretal e para controlar a dor associada com o mesmo
US6281211B1 (en) 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
GB9903476D0 (en) 1999-02-17 1999-04-07 Zeneca Ltd Therapeutic agents
US6451857B1 (en) 1999-03-10 2002-09-17 Warner-Lambert Company Analgesic compositions comprising anti-epileptic compounds and methods of using same
AU766648B2 (en) 1999-03-17 2003-10-23 Axys Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
AT409083B (de) 1999-04-01 2002-05-27 Sanochemia Pharmazeutika Ag Pharmazeutische, tolperison enthaltende zubereitung zur oralen verabreichung
US6610324B2 (en) 1999-04-07 2003-08-26 The Mclean Hospital Corporation Flupirtine in the treatment of fibromyalgia and related conditions
GB9915414D0 (en) 1999-07-01 1999-09-01 Glaxo Group Ltd Medical use
PT1200073E (pt) 1999-07-06 2007-03-30 Lilly Co Eli Antagonistas selectivos do receptor de iglur5 para o tratamento de enxaqueca
US6472165B1 (en) 1999-08-03 2002-10-29 Arzneimittelwerk Dresden Gmbh Modulatory binding site in potassium channels for screening and finding new active ingredients
US6495550B2 (en) 1999-08-04 2002-12-17 Icagen, Inc. Pyridine-substituted benzanilides as potassium ion channel openers
ATE380176T1 (de) 1999-08-04 2007-12-15 Icagen Inc Benzanilide als öffner des kaliumkanals
EP1200086A4 (en) 1999-08-04 2009-05-27 Icagen Inc THERAPEUTIC OR PROPHYLACTIC METHODS OF PAIN AND ANXIETY
US6117900A (en) 1999-09-27 2000-09-12 Asta Medica Aktiengesellschaft Use of retigabine for the treatment of neuropathic pain
US6383511B1 (en) 1999-10-25 2002-05-07 Epicept Corporation Local prevention or amelioration of pain from surgically closed wounds
US6538004B2 (en) 2000-03-03 2003-03-25 Abbott Laboratories Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
US20020015730A1 (en) 2000-03-09 2002-02-07 Torsten Hoffmann Pharmaceutical formulations and method for making
US6348486B1 (en) 2000-10-17 2002-02-19 American Home Products Corporation Methods for modulating bladder function
US6589986B2 (en) 2000-12-20 2003-07-08 Wyeth Methods of treating anxiety disorders
US6469042B1 (en) 2001-02-20 2002-10-22 Bristol-Myers Squibb Company Fluoro oxindole derivatives as modulators if KCNQ potassium channels
US20020183395A1 (en) 2001-04-04 2002-12-05 Wyeth Methods for treating hyperactive gastric motility
GB0121214D0 (en) 2001-08-31 2001-10-24 Btg Int Ltd Synthetic method
WO2003068769A1 (en) 2002-02-12 2003-08-21 Pfizer Inc. Non-peptide compounds affecting the action of gonadotropin-releasing hormone (gnrh)
WO2003097586A1 (en) 2002-05-17 2003-11-27 Janssen Pharmaceutica N.V. Aminotetralin-derived urea modulators of vanilloid vr1 receptor
WO2003106454A1 (en) 2002-06-12 2003-12-24 Orchid Chemicals & Pharmaceuticals Ltd 1h-isoquinoline-oxazolidinone derivaties and their use as antibacterial agents
AUPS312602A0 (en) 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
US7419981B2 (en) 2002-08-15 2008-09-02 Pfizer Inc. Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
US7045551B2 (en) 2002-11-22 2006-05-16 Bristol-Myers Squibb Company 1-aryl-2-hydroxyethyl amides as potassium channel openers
ATE488231T1 (de) 2002-12-23 2010-12-15 Icagen Inc Quinazolinone als kaliumkanalmodulatoren
ES2282701T3 (es) 2002-12-27 2007-10-16 H. Lundbeck A/S Derivados de 1,2,4-triaminobenceno utiles para tratar trastornos del sistema nervioso central.
EP1606247A1 (en) 2003-03-14 2005-12-21 H. Lundbeck A/S Substituted aniline derivatives
WO2004082677A1 (en) 2003-03-21 2004-09-30 H. Lundbeck A/S Substituted p-diaminobenzene derivatives
MXPA05010174A (es) 2003-04-25 2005-11-08 Lundbeck & Co As H Derivados de indol e indolina sustituidos.
WO2004105795A1 (en) 2003-05-27 2004-12-09 Altana Pharma Ag Pharmaceutical combinations of a proton pump inhibitor and a compound which modifies gastrointestinal motility
US20050070570A1 (en) 2003-06-18 2005-03-31 4Sc Ag Novel potassium channels modulators
JP2007505142A (ja) 2003-09-10 2007-03-08 セダーズ−シナイ メディカル センター 血液脳関門を通過する薬剤のカリウムチャネル媒介性送達
US20050089559A1 (en) 2003-10-23 2005-04-28 Istvan Szelenyi Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
DE10359335A1 (de) 2003-10-23 2005-05-25 Viatris Gmbh & Co. Kg Kombinationen aus Kaliumkanalöffnern und Natriumkanalinhibitoren oder Natriumkanal beeinflussenden Wirkstoffen zur Behandlung von Schmerzzuständen
ES2235626B1 (es) 2003-11-10 2006-11-01 Almirall Prodesfarma, S.A. Formas de administracion masticables, no comprimidas dosificadas individualmente.
US8236861B2 (en) 2004-02-13 2012-08-07 Hormos Medical Corporation Method for enhancing the bioavailablity of ospemifene
TWI349666B (en) 2004-03-12 2011-10-01 Lundbeck & Co As H Substituted morpholine and thiomorpholine derivatives
AU2005233642A1 (en) 2004-04-13 2005-10-27 Astellas Pharma Inc. Polycyclic pyridines as potassium ion channel modulators
RU2006139930A (ru) 2004-05-03 2008-06-10 Дюк Юниверсити (Сша/Сша) (Us) Составы для содействия снижению веса
UA89503C2 (uk) 2004-09-13 2010-02-10 Х. Луннбек А/С Заміщені похідні аніліну
CA2589001A1 (en) 2004-11-19 2006-05-26 Kissei Pharmaceutical Co., Ltd. Preventive or therapeutic agent for neuropathic pain
EP1688141A1 (en) 2005-01-31 2006-08-09 elbion AG The use of flupirtine for the treatment of overactive bladder and associated diseases, and for the treatment of irritable bowel syndrome
EP1861394A1 (en) 2005-03-03 2007-12-05 H.Lundbeck A/S Substituted pyridine derivatives
AU2006252519B2 (en) 2005-06-02 2012-08-30 Merck Sharp & Dohme Corp. HCV protease inhibitors in combination with food
US7683058B2 (en) 2005-09-09 2010-03-23 H. Lundbeck A/S Substituted pyrimidine derivatives
WO2007128462A1 (en) 2006-05-02 2007-11-15 Chris Rundfeldt Potassium channel activators for the prevention and treatment of dystonia and dystonia-like symptoms
CN101578259A (zh) 2006-11-28 2009-11-11 威朗国际制药公司 作为钾通道调节剂的1,4-二氨基双环瑞替加滨类似物
US20090018154A1 (en) 2007-05-17 2009-01-15 Endo Pharmaceuticals, Inc., A Corporation Of Delaware Opioid and methods of making and using the same
AR070513A1 (es) * 2007-08-01 2010-04-14 Lundbeck & Co As H Uso de abridores de canales de potasio kcnq para reducir los sintomas o tratar desordenes o afecciones en las cuales se encuentra anulado el sis-tema dopaminergico como por ejemplo esquizofrenia y trastorno depresivo mayor
JP2011506391A (ja) * 2007-12-11 2011-03-03 ノイロサーチ アクティーゼルスカブ カリウムチャネル活性化因子として有用な、新規の２−エチル−メチル−アミノ−３−アミド−６−アミノ−ピリジン誘導体
US20100323016A1 (en) 2008-07-18 2010-12-23 Biljana Nadjsombati Modified release formulation and methods of use
JP2013517315A (ja) 2010-01-20 2013-05-16 グラクソ グループ リミテッド 新規組成物
WO2013067591A1 (en) 2011-11-10 2013-05-16 Relevare Australia Pty Ltd Topical formulations for pain management
US10500216B2 (en) 2011-11-18 2019-12-10 Corcept Therapeutics, Inc. Optimizing mifepristone absorption
US9248122B2 (en) 2012-11-28 2016-02-02 Grünenthal GmbH Heteroquinoline-3-carboxamides as KCNQ2/3 modulators
EP4241843B1 (en) * 2018-02-20 2025-05-21 H. Lundbeck A/S Alcohol derivatives as kv7 potassium channel openers
WO2019217924A1 (en) 2018-05-11 2019-11-14 Xenon Pharmaceuticals Inc. Methods for enhancing the bioavailability and exposure of a voltage-gated potassium channel opener
TWI886158B (zh) 2019-10-10 2025-06-11 加拿大商再諾製藥公司 選擇性鉀通道調節劑之固態晶型
MX2022005490A (es) 2019-11-08 2022-08-10 Xenon Pharmaceuticals Inc Metodos para el tratamiento de trastornos depresivos.
CA3159876A1 (en) 2019-12-06 2021-06-10 James MURROUGH Method of treatment with kcnq channel openers
US20210213009A1 (en) 2019-12-13 2021-07-15 Xenon Pharmaceuticals Inc. Methods of treating pain
US20220288057A1 (en) 2021-02-09 2022-09-15 Xenon Pharmaceuticals Inc. Conjoint therapy for treating seizure disorders
US11957675B2 (en) 2021-02-09 2024-04-16 Xenon Pharmaceuticals Inc. Methods and uses for treating anhedonia
CA3151863C (en) 2021-10-27 2024-01-02 Shanghai Zhimeng Biopharma, Inc. Compound as potassium channel regulator and preparation and use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008024398A2 (en) * 2006-08-23 2008-02-28 Valeant Pharmaceuticals International Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators
US8293911B2 (en) 2006-08-23 2012-10-23 Valeant Pharmaceuticals International Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators
US8993593B2 (en) 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CAN ET AL., THE MOUSE FORCED SWIM TEST. J. VIS. EXP., vol. 59, 2012, pages e3638
CHOURBAJI, S. ET AL., BRAIN RES. PROTOC., vol. 16, 2005, pages 70 - 8
DULAWA, S.C.HEN, R., NEUROSCI. BIOBEHAV. REV., vol. 29, 2005, pages 771 - 625
NIELSEN, C.K. ET AL., BEHAV. BRAIN RES., vol. 107, 2000, pages 21 - 33
See also references of EP4054580A1
TAN AARON ET AL: "Effects of the KCNQ channel opener ezogabine on functional connectivity of the ventral striatum and clinical symptoms in patients with major depressive disorder", MOLECULAR PSYCHIATRY, BASINGSTOKE, GB, vol. 25, no. 6, 1 November 2018 (2018-11-01), pages 1323 - 1333, XP037145211, ISSN: 1359-4184, [retrieved on 20181101], DOI: 10.1038/S41380-018-0283-2 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12178811B2 (en) 2019-11-08 2024-12-31 Xenon Pharmaceuticals Inc. Methods of treating depressive disorders
EP4069226A1 (en) 2019-12-06 2022-10-12 Icahn School of Medicine at Mount Sinai Method of treatment with kcnq channel openers
WO2022173855A1 (en) * 2021-02-09 2022-08-18 Xenon Pharmaceuticals Inc. Voltage-gated potassium channel opener for use in treating anhedonia
US11957675B2 (en) 2021-02-09 2024-04-16 Xenon Pharmaceuticals Inc. Methods and uses for treating anhedonia

Also Published As

Publication number Publication date
NZ787838A (en) 2025-08-29
MA56607A1 (fr) 2022-10-31
US20210161886A1 (en) 2021-06-03
GEP20257732B (en) 2025-02-10
CN114667146A (zh) 2022-06-24
CO2022008001A2 (es) 2022-06-10
US20250108044A1 (en) 2025-04-03
CA3155812A1 (en) 2021-05-14
KR20220098746A (ko) 2022-07-12
EP4054580A1 (en) 2022-09-14
TW202128162A (zh) 2021-08-01
CR20220250A (es) 2022-08-19
IL292678A (en) 2022-07-01
PH12022551110A1 (en) 2024-02-26
BR112022008580A2 (pt) 2022-08-09
PE20221766A1 (es) 2022-11-11
US12178811B2 (en) 2024-12-31
GEAP202415942A (en) 2024-10-28
JP2026001049A (ja) 2026-01-06
MX2022005490A (es) 2022-08-10
AU2020380961A1 (en) 2022-05-26
JP2022553569A (ja) 2022-12-23
CL2022001102A1 (es) 2023-01-27

Similar Documents

Publication Publication Date Title
US12178811B2 (en) Methods of treating depressive disorders
Negus et al. Effects of kappa opioids in an assay of pain-depressed intracranial self-stimulation in rats
AU2011316225B2 (en) Combinations of serotonin receptor agonists for treatment of movement disorders
US20110034562A1 (en) Psycho-pharmaceuticals
Lejoyeux et al. Serotonin syndrome: incidence, symptoms and treatment
Maloney et al. Examining the reversibility of long-term behavioral disruptions in progeny of maternal SSRI exposure
KR20160078956A (ko) 취약 x 증후군 및 관련 장애의 치료 방법
US20140221385A1 (en) Combinations of serotonin receptor agonists for treatment of movement disorders
Willis et al. Recovery of experimental Parkinson's disease with the melatonin analogues ML-23 and S-20928 in a chronic, bilateral 6-OHDA model: a new mechanism involving antagonism of the melatonin receptor
Hilz et al. Sex differences in conditioned orienting and the role of estradiol in addiction-related behaviors.
EA048968B1 (ru) Способы лечения депрессивных расстройств
US20060179492A1 (en) Method of inhibiting neural transmission mediated by serotonin-2a and enhancing sensorimotor gating
AU2021383325A1 (en) Use of pridopidine and analogs for treating rett syndrome
CA3195241A1 (en) Compositions and uses thereof
Bee et al. A review article on depression evaluating models and history of antidepressants
HK40076951A (en) Methods of treating depressive disorders
WO2023215338A1 (en) Compositions and methods for treating cluster headache
WO2023215344A2 (en) Compositions and methods for treating cluster-tic syndrome
Levina et al. P. 4.014 Comparative study of Ladasten, Sydnocarb and their combination effects
CN105687647A (zh) 青娥丸抗抑郁抗焦虑的新用途
Dolan Non-motor symptoms in the aav-α-synuclein rat model of
Schuweiler Metergoline, the basolateral amygdala and the ventral pallidum: Implications for panic disorder

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20816351

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 3155812

Country of ref document: CA

ENP Entry into the national phase

Ref document number: 2022524695

Country of ref document: JP

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 15942

Country of ref document: GE

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112022008580

Country of ref document: BR

ENP Entry into the national phase

Ref document number: 20227017725

Country of ref document: KR

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 2020380961

Country of ref document: AU

Date of ref document: 20201106

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: NC2022/0008001

Country of ref document: CO

NENP Non-entry into the national phase

Ref country code: DE

WWP Wipo information: published in national office

Ref document number: NC2022/0008001

Country of ref document: CO

ENP Entry into the national phase

Ref document number: 2020816351

Country of ref document: EP

Effective date: 20220608

ENP Entry into the national phase

Ref document number: 112022008580

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20220503

WWE Wipo information: entry into national phase

Ref document number: 524452047

Country of ref document: SA

WWR Wipo information: refused in national office

Ref document number: 522432455

Country of ref document: SA

WWE Wipo information: entry into national phase

Ref document number: 522432455

Country of ref document: SA

WWE Wipo information: entry into national phase

Ref document number: 522432455

Country of ref document: SA

WWE Wipo information: entry into national phase

Ref document number: 522432455

Country of ref document: SA

WWD Wipo information: divisional of initial pct application

Ref document number: 823917

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 524452047

Country of ref document: SA