WO2021080353A2 - Appareil pour conditionnement de médicaments sous blister - Google Patents

Appareil pour conditionnement de médicaments sous blister Download PDF

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Publication number
WO2021080353A2
WO2021080353A2 PCT/KR2020/014504 KR2020014504W WO2021080353A2 WO 2021080353 A2 WO2021080353 A2 WO 2021080353A2 KR 2020014504 W KR2020014504 W KR 2020014504W WO 2021080353 A2 WO2021080353 A2 WO 2021080353A2
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WO
WIPO (PCT)
Prior art keywords
blister
drug
blister sheet
pocket
cover
Prior art date
Application number
PCT/KR2020/014504
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English (en)
Korean (ko)
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WO2021080353A3 (fr
Inventor
김호연
Original Assignee
(주)크레템
김호연
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Application filed by (주)크레템, 김호연 filed Critical (주)크레템
Publication of WO2021080353A2 publication Critical patent/WO2021080353A2/fr
Publication of WO2021080353A3 publication Critical patent/WO2021080353A3/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B11/00—Wrapping, e.g. partially or wholly enclosing, articles or quantities of material, in strips, sheets or blanks, of flexible material
    • B65B11/50—Enclosing articles, or quantities of material, by disposing contents between two sheets, e.g. pocketed sheets, and securing their opposed free margins
    • B65B11/52—Enclosing articles, or quantities of material, by disposing contents between two sheets, e.g. pocketed sheets, and securing their opposed free margins one sheet being rendered plastic, e.g. by heating, and forced by fluid pressure, e.g. vacuum, into engagement with the other sheet and contents, e.g. skin-, blister-, or bubble- packaging
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B35/00—Supplying, feeding, arranging or orientating articles to be packaged
    • B65B35/10—Feeding, e.g. conveying, single articles
    • B65B35/12—Feeding, e.g. conveying, single articles by gravity
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B61/00—Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages
    • B65B61/28—Auxiliary devices, not otherwise provided for, for operating on sheets, blanks, webs, binding material, containers or packages for discharging completed packages from machines

Definitions

  • the present invention relates to a blister packaging apparatus for a medicament that automatically dispenses a medicament into a plurality of medicament pockets of a blister sheet and attaches a cover to complete a blister pack.
  • Medicines prescribed by a prescription at a hospital or pharmacy are separately packaged in a plastic bag, each dose, or sealed in a blister pack.
  • the blister pack includes a blister sheet and a cover.
  • the blister sheet is formed with a plurality of drug pockets arranged in a matrix.
  • the cover is attached to the upper side of the blister sheet so that the plurality of drug pockets are sealed.
  • a blister packaging device for drugs that automatically distributes drugs to a plurality of drug pockets on a blister sheet and attaches a cover to complete the blister pack in order to improve the efficiency of packing drugs into blister packs according to prescriptions. Is required.
  • the present invention is a blister of a medicament that automatically drops a medicament from a plurality of medicament cassettes, distributes it to a plurality of medicament pockets of a blister sheet, and attaches a cover to the blister sheet to complete a blister pack in which the medicament is sealed.
  • a packaging device Provide a packaging device.
  • the present invention provides a blister packaging apparatus for a medicament comprising a medicament cassette, a blister sheet supply unit, a medicament dispensing unit, a cover attaching unit, and a blister transfer unit.
  • the blister sheet supply unit drops and supplies a blister sheet provided with a plurality of drug pockets in which drugs are accommodated.
  • the medicament dispensing unit dispenses and fills the medicaments dropped from at least some of the plurality of medicament cassettes into the plurality of medicament pockets.
  • the cover attaching unit forms a blister pack in which the plurality of drug pockets are sealed by attaching a cover to the upper side of the blister sheet filled with drugs in the plurality of drug pockets.
  • the blister sheet transfer unit transfers the blister sheet dropped from the blister sheet supply unit to the drug dispensing unit, and transfers the blister sheet filled with drugs into the plurality of drug pockets by the drug dispensing unit to the cover attachment unit. Transfer to.
  • the drug dispensing unit may include a dispensing frame and a shutter.
  • a plurality of pocket-corresponding holes are formed in the distribution frame to correspond to the plurality of drug pockets on a one-to-one basis.
  • the shutter selectively closes openings at the bottom of the plurality of pocket-corresponding through-holes.
  • a drug is injected into the plurality of pocket-corresponding through-holes while the openings at the bottom of the plurality of pocket-corresponding through-holes are closed by the shutter.
  • the distribution frame is positioned on the blister sheet so that the plurality of drug pockets of the blister sheet and the plurality of pocket-corresponding holes are aligned one-to-one. In that state, the opening at the bottom of the plurality of pocket-corresponding through-holes closed by the shutter is opened so that the medications accommodated in the plurality of pocket-corresponding through-holes can fall into the plurality of medication pockets.
  • medicines may be sequentially accommodated in a plurality of pocket-corresponding through-holes in which the opening at the lower end is closed.
  • the shutter includes a flat plate disposed under the distribution frame, the flat plate corresponding to a closed position for closing an opening at a lower end of the hole corresponding to all pockets of the distribution frame, and corresponding to all pockets of the distribution frame. It can be moved between the open positions to open the opening at the bottom of the through hole.
  • the blister packaging apparatus for drugs according to the present invention may further include a blister pack discharge conveyor for discharging the blister pack to the outside of the cover attachment unit.
  • the blister packaging apparatus for a drug according to the present invention automatically drops a drug from a plurality of drug cassettes according to a prescription, distributes it to a plurality of drug pockets of a blister sheet, and attaches a cover to the blister sheet to automatically drug the drug. Completes the sealed blister pack. Therefore, the efficiency of the prescription preparation operation using the blister sheet is improved and the cost is reduced.
  • the spread of drug packaging using blister sheets prevents theft, loss, and misuse of drugs, and allows patients to correctly take drugs even when the method of taking drugs is complicated. do.
  • FIG. 1 is a perspective view showing an example of a blister pack for drug packaging.
  • FIG. 2 is a front view of a blister packaging apparatus for a drug according to an embodiment of the present invention.
  • FIG. 3 is a plan view of the blister sheet supply unit of FIG. 2, illustrating a state in which blister sheets are not stacked.
  • 4 and 5 are a right side view and a front view of the blister sheet supply unit of FIG. 3.
  • FIG. 6 to 8 are views showing an enlarged view of part A of FIG. 5, and are views sequentially illustrating a process in which the lowermost layer of the blister sheet is separated and dropped from among a plurality of stacked blister sheets.
  • FIG. 9 is a plan view of the drug dispensing unit of FIG. 2.
  • FIG. 10 is a right side view of the cover attaching unit of FIG. 2.
  • FIG. 11 is a perspective view illustrating a cover supplied through the cover supply roller of FIG. 10.
  • 13 to 15 are views sequentially showing a process of attaching a cover to a blister sheet to complete a blister pack and separating the blister pack from the blister sheet tray.
  • a blister sheet for medicine packaging 2 used for packaging pharmaceuticals according to a prescription includes a flat sheet body 3 and a plurality of medicine pockets in which medicines 16 (refer to FIG. 6) are accommodated. pocket) (8).
  • Each medicine pocket 8 protrudes downward from the sheet main body 3, and an open pocket opening 9 is formed in the upper side so that the medicine 16 is injected.
  • Each medicament pocket 8 is filled with a single dose of medicament 16.
  • a plurality of medicament pockets 8 are arranged in a matrix. In the illustrated blister sheet 2, medicament pockets 8 are arranged in 7 rows and 4 columns so that a maximum of one week's worth of pharmaceuticals can be filled.
  • a type of cover 12 is attached.
  • the blister sheet (2) containing the drug and the cover (12) attached to the blister sheet (2) constitute a blister pack (1) that separates and seals the drug (16) by one dose. do.
  • the upper side of the blister sheet 2, specifically, the lower side of the cover 12 attached to the upper side of the sheet body 3 is an adhesive surface coated with an adhesive.
  • the blister packaging device 20 for drugs automatically divides the pharmaceuticals into one dose and fills them into a plurality of drug pockets 8 (see FIG. 1) of the blister sheet 2, and blisters A device for sealing the sheet 2 with the cover 12 to form the blister pack 1, and is mainly provided in large hospitals or pharmacies.
  • the drug blister packaging device 20 includes a housing 21, a drug supply section 22, a blister packaging section 35, and a controller (not shown).
  • the housing 21 has a cabinet shape.
  • the drug supply unit 22 is disposed on the inside of the housing 21.
  • the blister packaging portion 35 is disposed below the housing 21.
  • the controller controls the operation of the medicine supply unit 22 and the blister packaging unit 35.
  • the blister packaging unit 35 includes a blister sheet supply unit 50, a drug dispensing unit 37, a cover attaching unit 130, a blister sheet transfer unit 110, and a blister pack discharging conveyor 125. Equipped.
  • the drug supply unit 22 includes a plurality of drug cassettes 23 and hoppers 26 and 27.
  • the medicament cassette 23 accommodates different types of medicaments.
  • the hoppers 26 and 27 guide the drugs discharged from the drug cassette 23 to be collected and sequentially discharged downwards. Specifically, drugs are discharged from the drug cassette 23 filled with specific drugs according to a prescription input through a server or a user interface, and fall down through a drug drop passage (not shown).
  • the drugs are collected in a plurality of intermediate hoppers 26 disposed under a plurality of drug cassettes 23, and the drop order is adjusted to fall, and the drug test table 30 at the bottom of the final hopper 27 through the final hopper 27 It is collected in units of one dose.
  • the drugs collected on the drug examination table 30 are captured by an examination camera 29.
  • the inspection camera 29 is a sensor that detects whether the medicines collected in the medicine examination table 30 are the same as the one-time medicines according to the prescription.
  • the drugs collected on the drug test table 30 through the test camera 29 are not the same as the one dose amount of drugs according to the prescription, that is, if it is determined as an error, the drugs collected on the drug test table 30 are It is discharged to the error collection box 32 below the drug test table 30.
  • the drugs collected on the drug test table 30 through the test camera 29 are the same as the one-time dose of drugs according to the prescription, that is, if it is determined that there is no error, the drugs collected on the drug test table 30 are It falls to the drug dispensing unit 37 through a drop channel 33 under the drug test table 30.
  • the blister sheet supply unit 50 is a unit for supplying a plurality of stacked blister sheets 2 by dropping one by one, and is disposed inside the housing 21 on the left side of the drug dispensing unit 37.
  • the blister sheet supply unit 50 supplies a blister sheet 2 that is not filled with a drug to a plurality of drug pockets 8 (see FIG. 1 ).
  • the cover attaching unit 130 attaches the cover 12 to the upper side of the blister sheet 2 so that the plurality of drug pockets 8 filled with the drug 16 (refer to FIG. 13) are sealed, and the blister pack 1 ) (Refer to FIG. 1 ), and is disposed on the right side of the drug dispensing unit 37 inside the housing 21.
  • the drug dispensing unit 37 drops from at least a portion of the plurality of drug cassettes 23, falls through the intermediate hopper 26 and the final hopper 27, and is collected in the drug examination table 30 for one dose, and again. It is a unit that correctly dispenses and fills the medicines falling through the dropping channel 33 into the plurality of medicine pockets 8 of the blister sheet 2.
  • the blister sheet transfer unit 110 transfers the blister sheet 2 dropped from the blister sheet supply unit 50 to the drug dispensing unit 37, and a plurality of drug pockets by the drug dispensing unit 37 (8)
  • the blister sheet 2 filled with the medicine 16 (see FIG. 13) is transferred to the cover attaching unit 130.
  • the blister sheet transfer unit 10 includes a blister sheet tray 111 and a pair of guide rails 115 (see FIG. 13 ).
  • the blister sheet transfer unit 10 can intermittently move in a direction parallel to the Y axis under the blister sheet supply unit 50, the drug distribution unit 37, and the cover attachment unit 130.
  • the pair of guide rails 115 extend in a direction parallel to the Y axis to guide the movement of the blister sheet tray 111.
  • Guide rollers 114 are installed on the front and rear surfaces of the blister sheet tray 111 to guide the blister sheet tray 111 to move in a direction parallel to the Y axis by being fitted to the guide rail 115.
  • a plurality of drug pocket grooves 112 are formed on the upper side of the blister sheet tray 111.
  • a plurality of drug pockets 8 provided in the blister sheet 2 are fitted in a one-to-one correspondence. Accordingly, even if the blister sheet tray 111 on which the blister sheet 2 is seated moves at a high speed, the blister sheet 2 does not come off from the blister sheet tray 111.
  • the blister sheet tray 111 When the blister sheet 2 dropped from the blister sheet supply unit 50 is seated on the blister sheet tray 111 located under the blister sheet supply unit 50, the blister sheet tray 111 is It moves down and stops the medicine dispensing unit (37). In the medicine dispensing unit 37, the medicine corresponding to the prescription drops downward at a time, and the medicine 16 (refer to FIG. 13) is filled in the plurality of medicine pockets 8.
  • the blister sheet 2 A cover 12 (see Fig. 1) is attached to the upper side of the blister pack 1 (see Fig. 1) to complete the blister pack 1 (see Fig. 1).
  • the blister pack (1) is lifted up apart from the blister sheet tray (111), and the blister sheet tray (111) separated from the blister sheet (2) is not filled with a plurality of drug pockets (8).
  • the unused new blister sheet 2 falls and returns to a position below the blister sheet supply unit 50.
  • the blister pack discharge conveyor 125 is disposed between the pair of guide rails 115 of the blister sheet transfer unit 110 under the cover attachment unit 130.
  • the blister pack discharging conveyor 125 discharges the completed blister pack 1 with the cover 12 attached to the outside of the cover attaching unit 130, specifically, to a loading position outside the housing 21.
  • the blister sheet supply unit 50 includes a pair of outer walls 51, a pair of inner walls 55, a pair of electric motors 57, and a pair of screws. (screw) 60, a pair of first guide plates 64, a pair of second guide plates 70, a pair of first supports 80, a pair of second supports 90, and a separating blade (blade) (100) is provided.
  • the pair of inner walls 55 are arranged to be spaced apart by the width of the left and right sides of the blister sheet 2, that is, a width in a direction parallel to the Y axis, and in the longitudinal direction of the blister sheet 2, that is, parallel to the X axis. It extends in one direction.
  • the left and right ends of the blister sheet 2 that is, the first support end 4 and the second support end 5 are obliquely extended upward so that they do not get caught.
  • a pair of front end guides 106 and a pair of rear end guides 108 are fixedly supported at the front and rear ends of the pair of inner walls 55.
  • a pair of front end guides 106 and a pair of rear end guides 108 define positions of front and rear corners of the blister sheet 2 to be laminated.
  • a plurality of stacked blister sheets 2 are stacked in a loading space defined by the pair of inner walls 55, a pair of front end guides 106, and a pair of rear end guides 108.
  • the outline of the blister sheet 2 shown by the dashed-dotted line in FIG. 3 corresponds to the loading space of the blister sheet 2.
  • the pair of outer walls 51, a pair of electric motors 57, a pair of screws 60, a pair of first guide plates 64, a pair of second guide plates 70, one A pair of first supports 80, a pair of second supports 90, and a separating blade 100 are disposed to be symmetrical left and right with the loading space of the blister sheet 2 interposed therebetween.
  • Each outer wall 51 is disposed farther from the loading space of the blister sheet 2 than the corresponding inner wall 55 and extends along a plane parallel to the ZX plane.
  • the pair of first supports 80 are at both ends 4 and 5 of the blister sheet 2 stacked in the loading space of the blister sheet 2, that is, the first support end 4 and the second Supports the support end (5).
  • a pair of second supports 90 support both ends 4 and 5 of the blister sheet 2 under the pair of first supports 80.
  • the pair of first supports 80 and the pair of second supports 90 are each in a direction closer to each other so that both ends 4 and 5 of the blister sheet 2 are caught and supported. Moving in a direction away from each other so that both ends (4, 5) of the blister sheet (2) fall without being caught, but the pair of first supports (80) and the pair of second supports (90) Moves in opposite directions at the same time.
  • the first support 80 and the second support 90 arranged up and down on the left side of the loading space of the blister sheet 2 are arranged at the rear of the left side of the loading space of the blister sheet 2 It moves in the opposite direction at the same time by the power of the electric motor 57.
  • the first support 80 and the second support 90 arranged up and down on the right side of the loading space of the blister sheet 2 are arranged at the right rear of the loading space of the blister sheet 2 It moves in the opposite direction at the same time by the power of one electric motor 57.
  • each screw 60 is arranged to extend parallel to the X axis between the corresponding inner wall 55 and the outer wall 51, and rotates by the rotational power of the shaft of the electric motor 57.
  • Reference numerals 58 and 59 denote bevel gears fixed to one end of the rotating shaft of the electric motor 57 and the screw 60 so that the power of the electric motor 57 is transmitted to the screw 60 and meshed with each other.
  • Each of the first guide plates 64 is disposed on the upper side of the screw 60 between the corresponding inner wall 55 and the outer wall 51 and extends parallel to the X axis with a constant width.
  • Each second guide plate 70 is disposed under the screw 60 between the corresponding inner wall 55 and the outer wall 51 and extends parallel to the X axis with a constant width.
  • the front and rear ends of the first guide plate 64 and the second guide plate 70 disposed up and down are fixedly coupled to the upper and lower ends of the pair of connecting members 62.
  • a through hole through which the screw 60 passes is formed in the pair of connecting members 62.
  • a male thread pattern is formed on the outer circumferential surface of the screw 60, and a female thread pattern in which the male thread pattern of the screw 60 is engaged is formed on the inner circumferential surface of the through hole of the pair of connecting members 62.
  • Guide protrusions 65 and 71 protruding left and right are provided at the front and rear ends of the first guide plate 64 and the front and rear ends of the second guide plate 70.
  • the outer wall 51 and the inner wall 55 are formed with an upper guide groove 52 and a lower guide groove 53 extending in the front-rear direction and into which the guide protrusions 65 and 71 are fitted. Therefore, when the first guide plate 64 and the second guide plate 70 move in the front-rear direction by the power of the electric motor 57, the first guide plate 64 and the second guide plate 70 are not inclined and are horizontal. You can move in the forward and backward directions while maintaining the.
  • FIG. 6 to 8 are views showing an enlarged view of part A of FIG. 5, and are views sequentially illustrating a process in which the lowermost layer of the blister sheet is separated and dropped from among a plurality of stacked blister sheets.
  • a first support guide beam 76 and a second support guide beam 78 extending in the Y-axis between the corresponding outer wall 51 and the inner wall 55 Is installed. Both ends of the first support guide beam 76 and the second support guide beam 78 are fixedly supported on the outer wall 51 and the inner wall 55.
  • the first support guide beam 76 is disposed under the first guide plate 64
  • the second support guide beam 78 is disposed above the second guide plate 70
  • the second support guide beam 76 is disposed under the second guide plate 64.
  • the first support 80 is threaded on the first support guide beam 76 to be movable parallel to the Y axis
  • the second support 90 is a second support guide beam 78 to move parallel to the Y axis. It is threaded on.
  • Each of the first supports 80 includes a sliding member 81 that is slidably threaded through the first support guide beam 76, and a first protrusion protruding upward from the upper end of the sliding member 81. ) 82 and a first blade 85 extending from the lower end of the sliding member 81 toward the loading space of the blister sheet 2, that is, parallel to the positive Y-axis direction. do.
  • Each second support 90 includes a sliding member 91 that is slidably threaded through the second support guide beam 78, and a second connecting protrusion 92 protruding downward from the lower end of the sliding member 91. ), and a second blade 94 extending from the upper end of the sliding member 91 toward the loading space of the blister sheet 2, that is, parallel to the positive Y-axis direction.
  • the first blade 85 and the second blade 94 extend in a direction parallel to the longitudinal direction of the blister sheet 2, that is, parallel to the X axis.
  • the first blade 85 is positioned above the second blade 94.
  • the first blade 85 and the second blade 94 penetrate the inner wall 55 to protrude into the loading space of the blister sheet 2 55s) is formed.
  • the first guide plate 64 and the second guide plate 70 are formed with a first inclined groove 67 and a second inclined groove 73 that are inclined in opposite directions and extended.
  • an inclined groove 67 shown by a solid line indicates a first inclined groove
  • an inclined groove 73 shown by a dotted line indicates a second inclined groove.
  • the first inclined groove 67 extends obliquely so as to be closer to the outer wall 51 than the inner wall 55 from the rear to the front
  • the second inclined groove 73 is the inner wall of the outer wall 51 from the rear to the front. It extends obliquely to get closer to (55).
  • the first connecting protrusion 82 is fitted in the first inclined groove 67
  • the second connecting protrusion 92 is fitted in the second inclined groove 73.
  • the shapes of the first guide plate 64 and the second guide plate 70 shown by solid lines in FIG. 3 are the states of maximum movement in a direction parallel to the positive X-axis (+) direction.
  • the first connecting protrusion 82 is located at one end 68a of the first inclined groove 67
  • the second connecting protrusion 92 is located at one end 74a of the second inclined groove 73.
  • the end of the first blade 85 of the first support 80 penetrates the inner wall 55 through the blade protruding slot 55s, and is stacked on the blister sheet. It protrudes toward (2), and the end of the second blade 94 of the second support 90 does not protrude toward the stacked blister sheet 2 and is retracted.
  • the two-dot chain lines indicate the first guide plate 64 and the second guide plate 70 when the first guide plate 64 and the second guide plate 70 move as much as possible in a direction parallel to the direction of the negative X-axis (-). It indicates the position of both ends of.
  • first guide plate 64 and the second guide plate 70 move in parallel with the X-axis negative (-) direction from the position shown by the solid line to the location shown by the double-dashed line by the power of the electric motor 57
  • the first connecting protrusion 82 is moved from one end 68a to the other end 68b along the first inclined groove 67, and the second connecting protrusion 92 moves the second inclined groove 73 Accordingly, the position is moved from one end (74a) to the other end (74b).
  • the first blade 85 of the first support 80 retreats toward the outer wall 51 so that the end of the first blade 85 penetrates the inner wall 55 and is stacked. Does not protrude toward the blister sheet (2).
  • the second blade 94 of the second support 90 moves in a direction opposite to the moving direction of the first blade 85 so that the end of the second blade 94 penetrates the inner wall 55 and is stacked. It protrudes toward the seat (2).
  • the first guide plate 64 and the second guide plate 70 move in the positive direction of the X-axis from the position shown by the double-dashed line in FIG. 3 to the location shown by the solid line.
  • a pair of first supports 80 are in a state in which they are close to each other, and a pair of first blades 85 cross the pair of inner walls 55 inwardly.
  • both ends 4 and 5 (see FIG. 1) of the blister sheet 2BT of the lowermost layer are supported.
  • the pair of second supports 80 are separated from each other, that is, retreat close to the pair of outer walls 51, so that the pair of second blades 94 cross the pair of inner walls 55. It does not protrude inward.
  • the pair of first supports 80 are relative to each other.
  • the pair of first blades 85 does not protrude inward across the pair of inner walls 55 by retreating in a direction away from the pair of outer walls 51, that is, the pair of outer walls 51. 2
  • the support 90 moves in a direction closer to each other, that is, in a direction separated from the pair of outer walls 51, so that the pair of second blades 94 cross the pair of inner walls 55 and protrude inward. do.
  • the stacked plurality of blister sheets 2 descends by a height difference between the first blade 85 and the second blade 94, so that the lowermost layer of the blister sheet 2BT becomes a pair of second supports ( 90). Specifically, both end portions 4 and 5 (see Fig. 1) of the lowermost layer blister sheet 2BT are supported on a pair of second blades 94.
  • the pair of second supports 90 are shown in FIG. 6.
  • the pair of second blades 94 retreat in a direction away from each other, that is, in a direction closer to the pair of outer walls 51, so that the pair of second blades 94 do not protrude inwardly across the pair of inner walls 55.
  • the pair of first supports 80 move in a direction that is closer to each other, that is, in a direction spaced apart from the pair of outer walls 51, so that the pair of first blades 85 is moved to the pair of inner walls 55 ) And protrudes inward.
  • the lowermost layer of the blister sheet 2BT supported by the pair of second blades 94 falls down, and the immediately upper layer of the lowermost layer of the blister sheet 2 1 It is supported by the support base 80 and becomes the blister sheet 2 of the lowermost layer newly.
  • both ends 4 and 5 (see Fig. 1) of the blister sheet 2, which have become the lowermost layer, are supported on a pair of first blades 85.
  • the pair of first guide plates 64 and the pair of second guide plates 70 move back from the front to the rear, as described with reference to FIG.
  • the pair of first supports 80 It retreats again in the direction away from each other, and the pair of second supports 90 moves forward again in the direction closer to each other, so that a plurality of stacked blister sheets 2 are transferred to the first blade 85 and the second blade. 94) It descends again by the difference in height, and the newly lowered blister sheet 2 is supported by a pair of second supports 90.
  • the drug pocket 8 is formed of the drug pocket 8 of the blister sheet 2 stacked immediately below. It fits into the pocket opening 9. Since the outer surface of the upper layer of the drug pocket 8 and the inner surface of the lower layer of the drug pocket 8 are in frictional contact, the lowermost layer of the blister sheet 2BT is supported by a pair of blades 94 Even in a state in which the blister sheet 2BT of the lowermost layer does not fall down, the blister sheet 2BT may not fall down.
  • Separation blade 100 is to prevent the fall failure of the lowermost layer blister sheet (2BT), a pair of first support (80) is closer to each other, the layer immediately above the lowermost layer blister sheet (2BT) When the blister sheet (2) of the pair is supported by the first blade (85) of the pair of first supports (80), the blister sheet (2BT) of the lowermost layer is transferred to the blister sheet ( Press down to separate from 2).
  • the separation blade 100 is rotatably coupled to the first support 80 by a hinge 104.
  • the separation blade 100 is close to the center of the blade body 101 and the hinge 104, that is, the rotation center (RC) of the separation blade 100 for contact pressing the blister sheet (2BT) of the lowermost layer.
  • a trigger 102 protruding downward from one side of the blade main body 101 and close to the rotation center RC of the separation blade 100 and upward from the other side of the blade main body 101 It has a protruding impact protrusion 103.
  • a separation blade receiving groove 87 is formed in a portion of the lower side of the first blade 85 so that the blade body 101 overlaps the first blade 85 and is accommodated therein.
  • the separation blade In the second support (90), the angle (AN) between the separation blade (100) and the first support (80) when the pair of second supports (90) are close to each other, specifically, the separation blade ( An upper pusher 96 is provided to push the separation blade 100 so that the angle AN between the blade body 101 and the first blade 85 with respect to the rotation center RC of 100 is reduced. . 6 and 7, while the second support 90 moves in a direction away from the outer wall 51 and the first support 80 moves in a direction closer to the outer wall 51 at the same time, the blade The upper pusher 96 pushes the lower side of the blade body 101 so that the main body 101 rotates around the rotation center RC and is accommodated in the separation blade receiving groove 87.
  • the first support 80 can be smoothly retracted in a direction closer to the outer wall 51.
  • the trigger 102 is provided at a position that does not collide with the upper pusher 96. That is, the coordinate values in the X-axis direction of the position of the trigger 102 and the position of the upper pusher 96 are spaced apart so as to avoid collisions with each other.
  • the second support 90 further includes a trigger pusher 97.
  • the trigger pusher 97 is an angle (AN) between the separation blade 100 and the first support 80 when the pair of second supports 90 are separated from each other, specifically, the separation blade ( The trigger 102 is pushed so that the angle AN between the blade body 101 and the first blade 85 with respect to the rotation center RC of 100) increases.
  • the first support 80 moves in a direction away from the outer wall 51 and the second support 90 simultaneously moves in a direction closer to the outer wall 51, while the upper pusher 96 is spaced apart from the blade body 101, the trigger pusher 97 pushes the trigger 102 to increase the angle AN with the first blade 85 so that the blade body 101 is It rotates around the rotation center RC.
  • both end portions 4 and 5 (see Fig. 1) of the lowermost layer blister sheet 2BT together with the first blade 85 and the layer blister sheet 2 immediately above the lowermost layer blister sheet 2BT The ends of the blade body 101 entering between the ends 4 and 5 of the lowermost layer contact and press the ends 4 and 5 of the lowermost layer blister sheet 2BT. For this reason, the blister sheet 2BT of the lowermost layer falls down reliably.
  • the first support 80 has the collision so that the angle AN between the separation blade 100 and the first support 80 is not excessively large when the pair of second supports 90 are separated from each other.
  • a stopper 84 is provided to block the protrusion 103. 8, when the trigger pusher 97 pushes the trigger 102 to rotate the separation blade 100, the separation blade 100 may rotate excessively due to gravity, but the collision The protrusion 103 is blocked while colliding with the stopper 84 to prevent excessive rotation of the separating blade 100.
  • the lowermost layer of blister sheet 2BT separated from and falling from the stacked plurality of blister sheets 2 stands at a point below the blister sheet supply unit 50 It is seated on the blister sheet tray 111 being used.
  • the plurality of drug pockets 8 of the blister sheet 2 falling into the plurality of drug pocket grooves 112 formed on the upper side of the blister sheet tray 111 are fitted.
  • the blister sheet tray 111 on which the falling blister sheet 2BT is mounted moves to the lower point of the drug dispensing unit 37 and stops. Even if the blister sheet tray 111 on which the blister sheet 2BT is seated moves to the lower point of the drug dispensing unit 37 at a high speed, the blister sheet 2 is separated from the blister sheet tray 111 It doesn't work.
  • the drug dispensing unit 37 includes a dispensing frame 38 and a shutter 40.
  • the distribution frame 38 is a block having a substantially rectangular parallelepiped shape having a predetermined thickness, and has a plurality of pocket-corresponding holes 39 that are open in the vertical direction, that is, penetrate the distribution frame 38 in the thickness direction. .
  • the plurality of pocket-corresponding through holes 39 correspond to the plurality of drug pockets 8 of the blister sheet 2 on a one-to-one basis.
  • the plurality of pocket-corresponding through holes 39 of the distribution frame 38 shown in FIG. 9 are arranged in a matrix of 7 rows and 4 columns, similar to the plurality of drug pockets 8, and between adjacent pocket-corresponding through holes 39 The spacing of is also the same as the spacing between adjacent drug pockets (8).
  • the distribution frame 38 can be quickly moved in a horizontal direction orthogonal to a direction in which gravity acts, that is, a P1 direction parallel to the X axis and a P2 direction parallel to the Y axis.
  • the mechanism for moving the distribution frame 38 in the P1 direction and the P2 direction is not particularly limited.
  • the shutter 40 selectively closes an opening at the bottom of the plurality of pocket-corresponding through holes 39 formed in the distribution frame 38.
  • the shutter 40 has a flat plate disposed under the distribution frame 38.
  • the flat plate of the shutter 40 has a substantially rectangular shape, the front edge 41 and the rear edge 42 parallel to the Y axis and spaced apart from each other, and the left edge 43 and the right edge parallel to the X axis and spaced apart from each other. The shape is limited by (44).
  • the gap between the upper surface of the flat plate of the shutter 40 and the lower surface of the distribution frame 38 is smaller than the size of the smallest drug among the drugs accommodated in the drug cassette 23 so that the drug cannot be released.
  • the flat plate of the shutter 40 is a closed position to close the openings of the lower ends of all pocket-corresponding through holes 39 of the distribution frame 38, and the openings of the lower ends of all pocket-corresponding through-holes 39 of the distribution frame 38 It is movable between open positions to open it.
  • the flat plate of the shutter 40 moves in the OC direction parallel to the X axis.
  • the front edge 41, the rear edge 42, the left edge 43, and the right edge 44 shown by solid lines in FIG. 9 represent a flat plate in a closed position. Meanwhile, in FIG. 9, the shear edge 41 of the flat plate in the open position is shown by a two-dot chain line.
  • a mechanism for moving the flat plate of the shutter 40 in the OC direction is not particularly limited.
  • the front edge of the distribution frame 38 does not protrude forward beyond the front edge 41 of the flat plate
  • the rear edge of the distribution frame 38 does not protrude backward beyond the rear edge 42 of the flat plate
  • the left edge of the distribution frame 38 does not protrude to the left beyond the left edge 43 of the flat plate
  • the right edge of the distribution frame 38 does not protrude to the right beyond the right edge 44 of the flat plate. Therefore, even if the flat plate of the shutter 40 is stopped in the closed position, the openings at the lower ends of all the pocket-corresponding through-holes 39 of the distribution frame 38 remain closed.
  • the drug intermittently falls from the lower end of the drop channel 33 by one dose, and the closed Drugs are sequentially introduced and accommodated in the plurality of pocket-corresponding through holes 39.
  • the pocket-corresponding through-holes 39 in the first row and one column are positioned to be aligned in the vertical direction with the bottom of the drop channel 33.
  • the distribution frame 38 slightly moves in the direction P2, so that the pocket-corresponding through-holes 39 at the positions of the first row and the second row are formed in the drop channel ( 33) It is located so that it is aligned with the bottom and in the vertical direction. For example, in this way, one dose of medicine is sequentially filled from the pocket-corresponding through-hole 39 at the position of 1 row and 1 column to the pocket-correspondence through hole 39 at the 7th row and 4th column.
  • the drug may not be injected into the pocket-corresponding through-hole 39 of some of the plurality of pocket-corresponding through-holes 39.
  • the blister sheet tray 111 in which the blister sheet 2 filled with the prescription drug is mounted in the plurality of drug pockets 8 moves to the lower point of the cover attaching unit 130 and stops.
  • the shutter 40 having a flat plate shown in FIG. 9 is illustrative. Unlike this, the shutter provided in the drug dispensing unit of the present invention is hinged on the dispensing frame so that a plurality of pocket-corresponding apertures can be individually opened and closed. ) May be combined. Alternatively, when moving in the direction P1 or P2 of the distribution frame 38, the flat plate of the shutter may be linked to move in the same direction as the distribution frame 38.
  • FIG. 10 is a right side view of the cover attaching unit of FIG. 2
  • FIG. 11 is a perspective view illustrating a cover supplied through the cover supply roller of FIG. 10
  • FIG. 12 is an enlarged view of part XII of FIG. 10.
  • the cover attachment unit 130 of the blister sheet 2 includes a cover feed roller 136, a cover separator 140, a release film recovery roller 138, and a press plate 131.
  • the cover supply roller 136 is a roller that seamlessly supplies the release film 10 to which the cover 12 is detachably attached, and is disposed at the rear of the press plate 131.
  • a pressure-sensitive adhesive is applied to the lower side (12b) of the cover 12, and a release agent is applied to the upper side (10t) of the release film 10, so that the lower side (12b) of the cover 12 is applied to the release film ( It is detachably attached to the upper side 10t of 10).
  • a plurality of covers 12 are arranged in a line to be spaced apart at a predetermined interval GP and are attached to the release film 10.
  • the cover separator 140 separates the cover 12 attached to the release film 10 from the release film 10.
  • the cover 12 separated from the release film 10 by the cover separator 140 proceeds under the press plate 131.
  • the cover separator 140 includes a wedge 148, an electric motor 141, a screw 143, and a connecting member 145.
  • the wedge 148 includes an edge 149 protruding at an acute angle so that the moving direction of the release film 10 supplied from the cover supply roller 136 is bent at an acute angle (AW).
  • the wedge 148 has a forward position moved forward from just below the press plate 131 so that the edge 149 overlaps the rear end 133 of the press plate 131, and the press plate 131 When descending, it is possible to move between the retreat positions moved backward away from the press plate 131 so as not to collide with the press plate 131.
  • the wedge 148 shown by the solid line in FIG. 10 represents the wedge in the forward position
  • the wedge 148 shown by the double-dashed line represents the wedge in the retracted position.
  • the electric motor 141 provides power for the wedge 148 to move between the forward position and the retract position.
  • the screw 143 extends parallel to the X-axis direction, has a male screw pattern formed on its outer circumferential surface, is connected to a rotation shaft of the electric motor 141 and rotates by the power of the electric motor 141.
  • the connection member 145 has a through hole through which the screw 143 passes, and is coupled to the wedge 148.
  • a female screw pattern meshing with the male screw pattern of the screw 143 is formed on the inner circumferential surface of the through hole of the connection member 145, so that the connection member 145 and the connection member 145 are coupled thereto according to the direction in which the screw 143 rotates.
  • the wedge 148 is advanced or retracted.
  • the release film 10 to which the cover 12 is attached moves forward along the upper side surface 148u of the wedge 148. Passing the edge 149, the moving direction of the release film 10 is bent at an acute angle (AW). At this time, the cover 12 is not bent together with the release film 10, so it continues to advance while being separated from the release film 10. do.
  • the release film 10 from which the cover 10 is separated moves rearward along the inclined lower side 148l of the wedge 148.
  • the release film recovery roller 138 is a roller that winds and recovers the release film 10 from which the cover 12 is separated by the cover separator 140, and is located at the rear of the cover supply roller 136.
  • the press plate 131 adsorbs the release film 10 and the cover 12 separated from the release film 10 by the cover separator 140 and lowers the lower side 12b of the cover 12 to which the adhesive is applied to the blister sheet ( It is adhesively fixed to the upper side of 2), specifically to the upper side of the sheet main body 3.
  • the press plate 131 may be raised and lowered by the power of an actuator including a pneumatic cylinder.
  • a plurality of intake holes through which air is sucked by vacuum pressure is formed in the lower side 132 of the press plate 131.
  • the press plate 131 is connected to a vacuum suction pump (not shown) outside the press plate 131 through an intake tube 133.
  • the air blower 160 passes through the edge 149 of the wedge 148 and separates from the release film 10 to allow the cover 12 to be adsorbed to the lower side 132 of the press plate 131. Blowing toward the lower side 132 of the press plate 131.
  • an arrow indicated by a dashed-dotted line indicates the direction of travel of the high-pressure air discharged by the air blower 160.
  • the cover 12 separated from the release film 10 may be moved under the press plate 131 and the shear 13 (see Fig.
  • the cover 12 may be drooped down by gravity (gravity), and thus the cover 12 Is not adsorbed on the lower side of the press plate 131 and may fall, but the air blower 160 blows up the cover 12 so that it is reliably adsorbed on the lower side 132 of the press plate 131. do.
  • gravity gravitation
  • the cover detection sensor 152 detects the rear end 14 of the cover 10 that is separated from the release film 10 by the cover separator 140 and supplied to the press plate 131.
  • the cover detection sensor 152 includes, for example, a light emitting part 153 disposed above the rear end 133 of the press plate 131 and a light receiving part 154 disposed in the sensor receiving groove 15 provided in the wedge 148. ).
  • the release film 10 passes between the light emitting portion 153 and the light receiving portion 154 and proceeds to the edge 149.
  • the release film 10 is transparent, and the cover 12 is opaque.
  • the controller of the drug blister packaging device 20 determines that a single cover 12 is continuously supplied under the press plate 131 and the supply has not been completed.
  • the portion of the release film 10 between the pair of covers 12 spaced adjacently passes through the virtual line connecting the light-emitting part 153 and the light-receiving part 154, the projected from the light-emitting part 153 Light is incident on the light receiving unit 154.
  • the controller determines that the previous one cover 12 has been supplied under the press plate 131.
  • the cover detection sensor 152 has sensed the rear end 14 of the cover 12, and the cover ( It is determined that the rear end 14 (Fig. 11) of 12) has just passed through the virtual line connecting the light-emitting unit 153 and the light-receiving unit 154 so that one cover 12 has been supplied under the press plate 131 do.
  • the light irradiated from the light emitting unit 153 is detected by the light receiving unit 154 and not detected, it is determined that the front end 13 of the subsequent cover 12 starts to be supplied under the press plate 131.
  • the wedge 148 of the cover separator 140 is moved to the electric motor 141 before the press plate 131 descends. It will retreat by the power of This prevents the press plate 131 from colliding with the wedge 148.
  • the printer 156 prints characters or pictures on the upper side 12t (see Fig. 13) of the cover 12 before the cover 12 is separated from the release film 10 by the cover separator 140.
  • the cover 12 may be a thermal paper.
  • the printer 156 includes a printer head 157 that prints characters or pictures on the cover 12 in a thermal manner, and when the printer head 157 prints characters or pictures on the cover 12
  • a print support roller 158 is provided to support the cover 12 and adhere to the print head 157.
  • the print head 157 is movable in a direction toward the cover 12 supported by the print support roller 158 and in a direction away from the cover 12.
  • a blister pack (1) having a blister sheet (2) containing a drug 16 (see Fig. 15) and a cover (12) attached to the upper side of the blister sheet (2) is a press plate (131). It is lowered on the blister pack discharging conveyor 125 below, and discharged to a predetermined loading position outside the housing 21 by the blister pack discharging conveyor 125.
  • 13 to 15 are views sequentially showing a process of attaching a cover to a blister sheet to complete a blister pack and separating the blister pack from the blister sheet tray.
  • the cover attaching unit 130 will be described with reference to FIGS. 2, 10, and 13 to 15.
  • 2, 10, and 13 the blister sheet tray 111 on which the blister sheet 2 filled in the plurality of drug pockets 8 is seated in which the drug dropped from the drug dispensing unit 37 is described above. As described above, it moves and stops under the cover attachment unit 130, specifically under the press plate 131.
  • the blister sheet tray 111 moves along a pair of guide rails 115 extending in a direction parallel to the Y axis.
  • Guide rollers 114 are installed on the front and rear surfaces of the blister sheet tray 111 to guide the blister sheet tray 111 to move in a direction parallel to the Y axis by being fitted to the guide rail 115.
  • the blister pack discharge conveyor 125 is disposed between the pair of guide rails 115.
  • the press plate 131 When the blister sheet tray 111 is stopped under the press plate 131, the press plate 131 is in the raised position, and the wedge 148 of the cover separator 140 is in the forward position.
  • the cover 12 separated from the release film 10 while passing through the edge 149 of the wedge 148 is adsorbed on the lower side 132 of the press plate 131 as described above.
  • the air blower 160 blows high-pressure air to help the cover 12 to be adsorbed to the lower side 132 of the press plate 131. Then, the wedge 148 moves to the retracted position.
  • the press plate 131 adsorbing the cover 12 moves to the lowered position, and as shown in FIG. 13, the lower side 12b of the cover 12 is placed on the upper side of the blister sheet 2, specifically It is brought into close contact with the upper side of the seat body 3. Accordingly, the lower side 12b of the cover 12 to which the adhesive is applied is adhered to the upper side of the sheet body 3, and the drugs 16 accommodated in the plurality of drug pockets 8 are sealed in a blister pack. (1) is formed.
  • the press plate 131 moves to an elevated position while the lower side 132 of the press plate 131 adsorbs the cover 12. Accordingly, the blister pack 1 is lifted by the press plate 131 and separated from the blister sheet tray 111.
  • the blister sheet tray 111 separated from the blister pack 1 moves in a direction parallel to the Y-axis negative (-) direction, so that the plurality of drug pockets 8 are not filled with a new blister sheet ( 2) returns to the lower position of the blister sheet supply unit 50 in which it is dropped and seated.
  • the press plate 131 descends again while adsorbing the blister pack 1 Put the blister pack (1) on the pack discharge conveyor (125). Then, the press plate 131 stops inhaling air through the lower side 132 and rises again. Due to this, as shown in FIG. 15, the blister pack 1 is separated from the press plate 131 and placed on the blister pack discharge conveyor 125. The blister pack 1 is discharged to the blister pack loading position (not shown) outside the housing 21 by the blister pack discharge conveyor 125.
  • the cover attaching unit 130 By the cover attaching unit 130, the cover 12 is automatically attached to the upper side of the blister sheet 2 into which the drug 16 is injected, thereby completing the blister pack 1 in which the drug 16 is sealed. . Accordingly, the productivity and reliability of the automatic drug packaging operation using the blister sheet 2 are improved.
  • cover attaching unit 130 information for identifying the medicine 16 and the recipient of the medicine 16, and information on the method of taking the medicine 16 are transmitted to the printer 156 on the cover 12. ) Can be used to print, thereby preventing a delivery error of the blister pack 1 and promoting correct dose of the drug.
  • the present invention can be used in industries requiring pharmaceutical packaging, such as pharmacies, hospitals, and nursing homes.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Basic Packing Technique (AREA)
  • Containers And Plastic Fillers For Packaging (AREA)

Abstract

L'invention concerne un appareil pour conditionnement de médicaments sous blister, comprenant : une pluralité de bacs d'alimentation en médicaments recevant différents types de médicaments ; une unité d'alimentation en plaquettes alvéolées qui fournit, une par une, des plaquettes alvéolées qui sont pourvues d'une pluralité d'alvéoles pour médicament recevant des médicaments ; une unité de distribution de médicaments pour distribuer et introduire des médicaments, provenant d'au moins une partie de la pluralité de bacs d'alimentation en médicaments, dans la pluralité d'alvéoles pour médicament ; une unité de liaison de pellicule de fermeture qui lie une pellicule de fermeture à la surface supérieure d'une plaquette alvéolée dans laquelle une pluralité d'alvéoles pour médicament sont remplies de médicaments, pour former un blister dans lequel la pluralité d'alvéoles pour médicament sont hermétiquement fermées ; et une unité de transport de plaquettes alvéolées pour transporter une plaquette alvéolée provenant de l'unité d'alimentation en plaquettes alvéolées jusqu'à l'unité de distribution de médicaments et pour transporter la plaquette alvéolée, dans laquelle une pluralité d'alvéoles pour médicament ont été remplies de médicaments par l'unité de distribution de médicaments, jusqu'à l'unité de liaison de pellicule de fermeture.
PCT/KR2020/014504 2019-10-24 2020-10-22 Appareil pour conditionnement de médicaments sous blister WO2021080353A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020190133239A KR102346557B1 (ko) 2019-10-24 2019-10-24 약제의 블리스터 포장 장치
KR10-2019-0133239 2019-10-24

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WO2021080353A2 true WO2021080353A2 (fr) 2021-04-29
WO2021080353A3 WO2021080353A3 (fr) 2021-07-15

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Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
JP2001048350A (ja) * 1999-08-10 2001-02-20 Sanyo Seisakusho:Kk ワークの移送ミス防止装置
KR100343788B1 (ko) 2000-07-08 2002-07-20 오영현 환약용 블리스터 포장기
US7426814B2 (en) * 2005-12-23 2008-09-23 Qem, Inc. Method of dispensing pills from a movable platen
KR101591990B1 (ko) * 2013-12-10 2016-02-05 에이치엠에이치 주식회사 작은 입자 약제 포장 장치
KR20170068285A (ko) * 2015-12-09 2017-06-19 에이치엠에이치 주식회사 약제의 블리스터 포장 장치
KR20170068284A (ko) * 2015-12-09 2017-06-19 에이치엠에이치 주식회사 약제의 블리스터 포장 장치

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WO2021080353A3 (fr) 2021-07-15
KR20210048938A (ko) 2021-05-04

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