WO2021075900A1 - Dispositif d'injection de solution chimique et procédé de préparation d'injection de solution chimique - Google Patents

Dispositif d'injection de solution chimique et procédé de préparation d'injection de solution chimique Download PDF

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Publication number
WO2021075900A1
WO2021075900A1 PCT/KR2020/014153 KR2020014153W WO2021075900A1 WO 2021075900 A1 WO2021075900 A1 WO 2021075900A1 KR 2020014153 W KR2020014153 W KR 2020014153W WO 2021075900 A1 WO2021075900 A1 WO 2021075900A1
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WIPO (PCT)
Prior art keywords
chemical liquid
chemical
priming
chemical solution
storage space
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Application number
PCT/KR2020/014153
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English (en)
Korean (ko)
Inventor
김용현
Original Assignee
김용현
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020200009361A external-priority patent/KR102373991B1/ko
Application filed by 김용현 filed Critical 김용현
Priority to JP2022522596A priority Critical patent/JP2022553172A/ja
Priority to CN202080072182.7A priority patent/CN114585401A/zh
Priority to US17/767,562 priority patent/US20240058549A1/en
Publication of WO2021075900A1 publication Critical patent/WO2021075900A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/162—Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/165—Filtering accessories, e.g. blood filters, filters for infusion liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/36—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body

Definitions

  • the present disclosure relates to a chemical solution injection device and a method for preparing a chemical solution injection.
  • a drug solution injection device for injecting a liquid drug solution (eg, injection solution) to a patient.
  • a liquid drug solution eg, injection solution
  • the chemical liquid in a predetermined storage space passes through a passage connected to the patient (for example, an inner space of a tube and an injection needle), and flows into the patient's body.
  • Initial air is filled inside a tube of the first chemical injection device, and a priming operation of removing air from the inside by filling the tube with saline solution or a chemical solution before connecting the chemical solution injection device to the patient is known.
  • the present disclosure provides an apparatus for preventing injection interruption due to air bubbles inside the apparatus when a chemical solution is injected into a human body.
  • the present disclosure provides a device designed to facilitate priming, which is a process for removing air bubbles inside the device.
  • the present disclosure provides a method for simplifying priming, which is a process for removing air bubbles inside a device.
  • a chemical injection device configured to form an internal space for storing a chemical liquid, a priming storage space extending from the internal space is formed, and one end of the priming storage space is the priming storage space and the A chemical liquid storage unit configured to be located at a connection point of the inner space; And a chemical liquid flow part configured to be coupled to the chemical liquid storage part, and forming a guide flow path of the chemical liquid configured to be connectable to the other end of the priming storage space in a state of being coupled to the chemical liquid storage part.
  • the chemical liquid storage unit a chemical liquid pumping device configured to pressurize the chemical liquid in the inner space; And a chemical liquid injection valve disposed at the other end of the priming storage space and configured to open and close the priming storage space.
  • the chemical liquid flow unit may include a coupling member configured to be coupled to the chemical liquid injection valve; And a chemical liquid flow line extending from the coupling member to form the guide flow path.
  • the chemical liquid injection device is configured such that when the coupling member is coupled to the chemical liquid injection valve, the chemical liquid injection valve is opened by the coupling member to connect the other end of the priming storage space to the guide flow path.
  • a method for preparing a chemical solution injection includes a chemical solution storage step of introducing a chemical solution into an inner space of a chemical solution pumping device through a chemical solution injection valve; A priming liquid storage step of introducing a priming liquid in the direction of the inner space through the chemical liquid injection valve; A flow path connecting step of coupling a chemical liquid flow part to the chemical liquid injection valve to connect a guide flow path of the chemical liquid flow part and the inner space; And a priming step in which the chemical liquid pumping device pressurizes the inner space so that the priming liquid flows before the chemical liquid along the guide flow path.
  • priming is a process for removing air bubbles inside the chemical injection device.
  • FIG. 1 is a conceptual diagram showing the entire system of a chemical solution injection device 1 according to a first embodiment of the present disclosure.
  • FIG. 2 is a partially cutaway elevational view of a chemical solution injection device 2 according to a second exemplary embodiment of the present disclosure.
  • FIG. 3 is a partially cut-away elevational view showing the next appearance according to the preparation process for use of the chemical solution injection device 2 of FIG. 2.
  • FIG. 4 is a partially cut-away elevational view showing the next state according to the preparation process for use of the chemical solution injection device 2 of FIG. 3.
  • FIG. 5 is a partially cut-away elevational view showing the next appearance according to the preparation process for use of the chemical solution injection device 2 of FIG. 4.
  • FIG. 6 is a partially cut-away elevational view showing the next state according to the preparation process of the chemical solution injection device 2 of FIG. 5.
  • FIG. 7 is a partially cut-away elevational view showing the next appearance according to the preparation process of the chemical solution injection device 2 of FIG. 6.
  • FIG. 8 is a cross-sectional view showing a chemical solution injection device 2'according to a modification of the second embodiment of the present disclosure.
  • FIG. 9 is a perspective view of the chemical solution injection device 2'of FIG. 8, showing a state in which the chemical solution storage unit 10 and the chemical solution flow unit 20 are separated from each other.
  • FIG. 10 is a perspective view of the chemical solution injection device 2'of FIG. 8, showing a state in which the chemical solution storage unit 10 and the chemical solution flow unit 20 are coupled to each other.
  • FIG. 11 is a partial cross-sectional view showing the state of the chemical solution injection valve 13 in FIG. 9.
  • FIG. 12 is a partial cross-sectional view showing the state of the chemical solution injection valve 13 in FIG. 10.
  • Embodiments of the present disclosure are illustrated for the purpose of describing the technical idea of the present disclosure.
  • the scope of the rights according to the present disclosure is not limited to the embodiments presented below or specific descriptions of these embodiments.
  • a component when referred to as being "connected” or “coupled” to another component, the component may be directly connected to or coupled to the other component, or a new It is to be understood that it may be connected or may be combined via other components.
  • Upstream and downstream used in the present disclosure are defined based on the direction in which the chemical liquid flows when the chemical liquid pumping devices 100 and 11 pressurize the chemical liquid. Specifically, directions of arrows F2 and F3 in FIG. 1 are defined as a downstream direction, and a direction opposite to the downstream direction is defined as an upstream direction.
  • FIG. 1 is a conceptual diagram showing the entire system of a chemical solution injection device 1 according to a first embodiment of the present disclosure.
  • the method for preparing the chemical solution injection and the method for injecting the chemical solution according to the first exemplary embodiment are sequentially performed.
  • the priming liquid flows along the extension tube 300.
  • the priming liquid flowing along the extension tube 300 is introduced into the external filter modules 500 and 500 and the chemical liquid transfer pipe device 800 for controlling the flow rate.
  • the chemical liquid transfer pipe device 800 may be a chemical liquid transfer pipe device in which an air filter is integrally formed.
  • the chemical liquid transfer pipe device 800 may include a chemical liquid transfer pipe 820 that limits the flow rate per hour of the chemical liquid.
  • the chemical liquid transfer pipe 820 has a capillary flow path.
  • the chemical liquid transfer pipe 820 may have a function of limiting the flow rate per hour of the chemical liquid.
  • the chemical liquid transfer pipe 820 may include a capillary tube.
  • the chemical liquid transfer pipe 820 may include a polymer microtube.
  • the chemical liquid transfer pipe 820 may be formed of various shapes and materials having a capillary flow path.
  • the capillary flow path may have a diameter of about 0.04 to 0.08 mm, thereby limiting the flow rate of the chemical solution per hour.
  • the chemical liquid injection device 1 may include an end cap 700 that is detachably connected to the downstream side of the chemical liquid transfer pipe device 800. Air inside the extension tube 300 may be discharged to the outside through the end cap 700.
  • the priming liquid is filled in the extension tube 300 and the chemical liquid transfer pipe device 800.
  • the priming liquid may be a liquid different from the chemical liquid, which can be injected into a patient and has a lower risk when exposed to air compared to the chemical liquid.
  • the priming liquid may be saline.
  • the end cap 700 is configured such that the air passing through the chemical liquid transfer pipe device 800 and the priming liquid are introduced into the interior.
  • the end cap 700 may be configured to allow air to flow to the outside but prevent the priming liquid from leaking to the outside.
  • the end cap 700 includes a vent filter 710 that blocks the passage of the priming liquid but allows the passage of the gas.
  • the vent filter 710 includes a hydrophobic filter.
  • the end cap 700 may include a sponge 720 disposed on the upstream side of the vent filter 710.
  • the end cap 700 includes an end cap casing 730 accommodating the vent filter 710 therein.
  • the end cap casing 730 accommodates the sponge 720 therein.
  • the end cap casing 730 forms a vent hole 730a through which gas passes.
  • the end cap 700 includes an end cap coupling portion 740 configured to be coupled to a downstream connection portion 815a of the chemical liquid transfer pipe device 800. Arrow E2 of FIG. 1 shows the coupling and separation directions of the end cap coupling portion 740 with respect to the downstream connection portion 815a.
  • the end cap 700 When the liquid for priming is filled in the end cap 700, the end cap 700 is separated from the chemical liquid transfer pipe device 800, and the chemical liquid transport pipe device 800 and the patient connection units 600, 600' are connected. I can.
  • the patient connection units 600 and 600 ′ may include an injection needle 610 or a catheter.
  • the patient connection units 600 and 600' include components such as an injection needle 610 that are inserted into the body of the patient.
  • the patient connection units 600 and 600 ′ may include “injection parts including components such as the injection needle 610 that are introduced into the patient's body” and “remaining parts”.
  • the lead-in part and the other part may be detachably coupled to each other.
  • the user in a state where the lead-in part is connected to the patient but is separated from the remaining parts, the user may combine the remaining parts with the chemical liquid transfer pipe device 800, and then combine the lead-in parts and the remaining parts with each other. I can.
  • the liquid passing through the chemical liquid transfer pipe device 800 may be sequentially introduced into the patient's body through the remaining parts and the inlet parts.
  • the patient connection units 600 and 600 ′ include an injection support 620 that supports the injection needle 610.
  • the patient connection unit (600, 600') includes a unit coupling portion (630) configured to be coupled to the downstream connection portion (815a) of the chemical liquid transfer pipe device (800).
  • Arrow E3 of FIG. 1 shows the coupling and separation directions of the unit coupling portion 630 with respect to the downstream connection portion 815a.
  • the patient connection unit 600 may be configured by sequentially connecting the injection needle 610, the injection support 620, and the unit coupling unit 630.
  • the patient connection unit 600 ′ further includes a patient connection tube fixing part 650 ′ connected to the downstream side of the unit coupling part 630.
  • the patient connection unit 600 ′ further includes a patient connection pipe 640 ′ connecting the patient connection pipe fixing part 650 ′ and the injection support part 620.
  • the patient connector 640 ′ may be formed of a flexible material.
  • the patient connection unit 600' consists of an injection needle 610, an injection support 620, a patient connector 640', a patient connector fixing portion 650', and a unit coupling portion 630 sequentially connected. Can be.
  • the chemical liquid is introduced into the body of the patient according to the pressurization of the chemical liquid pumping device 100.
  • the chemical solution is a liquid containing a therapeutic substance.
  • the priming liquid may first flow into the patient's body, and a chemical liquid flowing after the priming liquid may flow into the patient's body.
  • the chemical liquid pumping device 100 includes a chamber 110 configured to accommodate a chemical liquid.
  • the chamber 110 forms an inner space together with the pressing unit 120.
  • a chemical solution may be stored in the inner space.
  • saline solution or the like may be temporarily stored in the internal space.
  • a discharge port part 111 through which the liquid inside the chamber 110 is discharged is formed.
  • the chemical liquid pumping device 100 is configured to pressurize the chemical liquid.
  • the chemical liquid pumping device 100 includes a pressurizing unit 120 that pressurizes the liquid inside the chamber 110.
  • the pressing unit 120 can pressurize the liquid inside the chamber 110 by moving in a predetermined pressing direction Ap1. When the liquid is being filled into the chamber 110, the pressing unit 120 moves in a direction Ap2 opposite to the pressing direction Ap1. In FIG. 1, with reference to 120A, a position in which the pressing unit 120 is moved in the opposite direction Ap2 is shown.
  • the chemical liquid pumping apparatus 100 may include a pressing operation unit 130 that provides power so that the pressing unit 120 moves in the pressing direction Ap1.
  • the pressurizing operation unit 130 may be configured to pressurize a liquid in the chamber 110 using volume expansion by gas activation.
  • the pressing operation unit 130 may provide a portion that can be grasped by the user to move the pressing unit 120 in the pressing direction Ap1 by the user's force.
  • the pressing unit 120 may be configured to pressurize a liquid using an elastic force of an elastic body such as a balloon.
  • the pressurizing unit 120 may be configured to pressurize the liquid in the balloon.
  • the chemical liquid injection valve 200 is configured to be able to fill a liquid into the chamber 110.
  • the liquid may be introduced into the extension tube 300 or the chamber 110 through the chemical solution injection valve 200 from the outside.
  • the chemical liquid injection valve 200 is connected to the extension tube 300, but in another embodiment not shown, the chemical liquid injection valve 200 may be connected to the chamber 110.
  • the chemical injection valve 200 includes a first extension part 210 connected to a downstream end of the first connection part 310 of the extension tube 300 and an upstream side of the second connection part 320 of the extension tube 300. It includes a second extension 220 connected to the end.
  • the chemical injection valve 200 includes an inlet portion 230 configured to allow liquid to flow from the outside, and an inlet port opening/closing portion 240 configured to be detachably coupled to the inlet portion 230.
  • Arrow E1 of FIG. 1 shows the direction of coupling and separation of the inlet port opening/closing part 240 to the inlet part 230.
  • the extension tube 300 is configured to guide the flow of the priming liquid.
  • the extension tube 300 may guide the movement of the chemical liquid from the chemical liquid pumping device 100 to the chemical liquid transfer pipe device 800.
  • the extension tube 300 is configured to flow the chemical liquid discharged from the chemical liquid pumping device 100 according to the pressure in the chemical liquid pumping device 100.
  • the upstream end of the extension tube 300 is connected to the chemical liquid pumping device 100.
  • the extension tube 300 includes an upstream connection part 350 connected to the chemical liquid injection/discharge port part 111 of the chemical liquid pumping device 100.
  • the downstream end of the extension tube 300 is connected to the chemical liquid transfer pipe device 800.
  • the liquid passing through the extension tube 300 is introduced into the chemical liquid transfer pipe device 800 through an inlet port of the chemical liquid transfer pipe device 800.
  • the extension tube 300 includes a first connection part 310 connecting the upstream connection part 350 and the first extension part 210 of the chemical solution injection valve 200.
  • the extension tube 300 includes a second connection part 320 connecting the second extension part 220 of the chemical solution injection valve 200 and the external filter module 500.
  • the extension tube 300 includes a third connection part 330 connecting the external filter module 500 and the downstream end of the extension tube 300.
  • the chemical injection device 1 may include at least one connector opening/closing module 400.
  • the connector opening/closing module 400 may block the flow of liquid at one point of the extension tube 300 by pressing the outside of the extension tube 300.
  • the at least one connector opening/closing module 400 includes a first opening/closing module 410 capable of changing whether or not a point B1 of the first connection part 310 is opened or closed, and a point B2 of the second connection part 320.
  • the connector opening and closing module 400 may be configured in a clamp shape.
  • the chemical injection device 1 may include an external filter module 500 disposed on the extension tube 300.
  • the external filter module 500 may include a filter casing 510 connected to the extension tube 300 and a filter 520 disposed in the filter casing 510.
  • a particle filter for filtering impurities, an air filter for filtering air bubbles (bubbles), or a combination thereof may be used as the filter 520 of the external filter module 500.
  • An air vent configured to discharge air caught in the air filter to the outside may be formed in the external filter module 500.
  • a method for preparing a chemical solution injection and a method for injecting a chemical solution according to the first embodiment will be described as follows.
  • the inlet port opening/closing part 240 is separated from the inlet part 230, and the first connection part 310 is blocked by the first connection pipe opening/closing module 410 (B1 Note), the rest of the extension tube 300 except for the first connection part 310 is opened.
  • the liquid for priming such as saline
  • the inside of the extension tube 300 and the inside of the chemical liquid transfer pipe device 800 are filled with the priming liquid.
  • the method for injecting the chemical solution according to the first embodiment is performed.
  • the inlet port opening/closing part 240 is separated from the inlet part 230, and the second connection part 320 is blocked by the second connection pipe opening/closing module 420 (see B2). ), the first connector opening and closing module 410 is separated from the first connector 310 to open the first connector 310.
  • the pressurization unit 120 moves in the direction Ap2.
  • the inlet port opening/closing unit 240 is coupled to the inlet unit 230 and the second connector opening/closing module 420 is separated from the second connection unit 320 to open the extension tube 300.
  • the pressing unit 120 is then moved in the pressing direction Ap1, so that the chemical solution may sequentially pass through the extension tube 300 and the chemical solution transfer pipe device 800.
  • the chemical liquid injection device 1 according to the first embodiment described above is the priming liquid (for example, saline) by pressing the syringe for a long time while the syringe is connected to the inlet 230 for priming. There is a discomfort of having to inject.
  • the chemical solution injection device 1 according to the first embodiment transfers air located inside the first connection part 310 connecting the upstream connection part 350 and the first extension part 210 to each other according to the first embodiment. It cannot be removed in the preparation method of chemical injection.
  • the chemical liquid injection device 2 according to the second embodiment described below with reference to FIGS. 2 to 12 makes it convenient to inject the priming liquid, and air remains inside the tube by priming. It eliminates or reduces the phenomenon.
  • the chemical solution injection device 2 and the method for preparing the chemical solution injection according to the second embodiment will be described as follows.
  • the chemical liquid injection device 2 is a view of a chemical liquid injection device 2 according to a second embodiment of the present disclosure, and is a partially cutaway elevational view of the chemical liquid injection device 2.
  • the chemical liquid injection device 2 is provided in a state where the chemical liquid storage unit 10 and the chemical liquid flow part 20 are separated from each other, and the chemical liquid storage part 10 and the chemical liquid flow part 20 are Can be combined. Once the chemical storage unit 10 and the chemical fluid flow unit 20 are combined, it may be configured to be impossible to separate by a general method of use.
  • the chemical solution storage unit 10 and the chemical solution flow unit 20 may be separated from each other based on the boundary between the chemical solution injection valve 13 and the coupling member 21.
  • the chemical liquid storage unit 10 may include a chemical liquid pumping device 11, a chemical liquid storage line 12, and a chemical liquid injection valve 13.
  • the chemical liquid flow unit 20 includes a coupling member 21 configured to be coupled to the chemical liquid injection valve 13, a chemical liquid flow line 22, an air filter (air filter) 23, and a chemical liquid transfer pipe device 24. can do.
  • the chemical solution injection device 2 may include an end cap 700 detachably coupled to a downstream end of the chemical solution flow unit 20. In this embodiment, the end cap 700 may be detachably coupled to the downstream end of the chemical liquid transfer pipe device 24.
  • both a priming step to be described later and a chemical liquid injection step of injecting a chemical liquid into a patient may be performed.
  • the priming step constitutes a part of a method for preparing a chemical solution injection according to a second exemplary embodiment, which will be described later, and the chemical injection step is performed after a method for preparing a chemical solution injection according to a second exemplary embodiment, which will be described later, is performed.
  • the end cap 700 is coupled to the downstream end of the chemical liquid flow unit 20
  • the priming step may be performed.
  • the priming step is performed in a state in which the patient and the chemical injection device are separated.
  • the end cap 700 is separated from the downstream end of the drug solution flow unit 20, and the patient connection unit 600 at the downstream end of the drug solution flow unit 20, 600') can be connected.
  • the step of injecting the chemical solution may be performed while a device for injecting the chemical solution is connected to the patient.
  • the chemical solution storage unit 10 is configured to form an inner space 10s for storing the chemical solution.
  • the inner space 10s may be formed inside the chamber 110 of the chemical liquid storage unit 10.
  • the inner space 10s may be formed by the chamber 110 and the pressurizing unit 120 of the chemical liquid storage unit 10.
  • the chemical solution may be filled in the inner space 10s.
  • a priming storage space 10p extending from the internal space 10s is formed.
  • One end 10pa of the priming storage space 10p may be located at a connection point between the priming storage space 10p and the inner space 10s.
  • the other end 10pb of the priming storage space 10p may be located at a connection point between the priming storage space 10p and the chemical liquid injection valve 13.
  • the priming liquid may be filled in the priming storage space 10p.
  • the priming liquid injected into the chemical liquid storage unit in the priming liquid storage step to be described later may be stored in the priming storage space, and in the priming step to be described later, the priming liquid in the priming storage space flows the chemical liquid of the chemical liquid flow unit 20 By moving to the line 22, it is possible to prime the entire chemical liquid flow unit 20.
  • the priming storage space 10p may be a flow path connected from one end 10pa to the other end 10pb. Accordingly, the chemical solution can be introduced into or out of the internal space 10s through the priming storage space 10p, and at the same time, the priming storage space 10p is used as a space in which the priming liquid is stored. I can.
  • the priming storage space 10p may be formed to be longer along the movement direction of the chemical solution than a width in a direction perpendicular to the movement direction (ie, upstream and downstream direction) of the chemical solution in the priming storage space 10p. Accordingly, when the chemical liquid is pressurized in the priming step to be described later, some of the chemical liquid in the priming storage space 10p may make it difficult to move beyond the frying liquid in the downstream direction.
  • the priming storage space 10p may include a partial space 10p1 in the chemical liquid pumping device 11 and/or a space 10p2 in the chemical liquid storage line 12.
  • the priming storage space 10p may include an inner storage space 10p1 that extends upstream from the inside of the chemical liquid pumping device 11 and includes one end 10pa of the priming storage space 10p.
  • the priming storage space 10p may include an outer storage space 10p2 extending from the outside of the chemical liquid pumping device 11 to a downstream side and including the other end 10pb of the priming storage space 10p. In this embodiment, the upstream end of the outer storage space 10p2 is connected to the downstream end of the inner storage space 10p1 to form a priming storage space 10p.
  • the chemical liquid injection valve 13 is disposed at the other end 10pb of the priming storage space 10p.
  • the chemical liquid injection valve 13 may be coupled to a downstream end of the chemical liquid storage line 12.
  • the chemical liquid injection valve 13 is configured to open and close the priming storage space 10p.
  • the chemical liquid injection valve 13 may be configured to open the flow path in a state in which the front end (ie, the downstream end) is pressurized in the upstream direction, and close the flow path in a state in which such pressure is released.
  • the chemical solution injection valve 13 may be configured to open the flow path when it is pressurized by the syringes X1 and X2 to be described later, and may be configured to close the flow path when the pressure from the syringes X1 and X2 is released.
  • the chemical liquid injection valve 13 may be configured to be coupled to the coupling member 21 of the chemical liquid flow unit 20.
  • the chemical liquid injection valve 13 may be configured to open a flow path in a state in which the chemical liquid injection valve 13 is coupled with the coupling member 21 to connect the priming storage space 10p and the guide flow path 20p.
  • the chemical liquid storage line 12 is coupled to the chemical liquid pumping device 11.
  • the upstream end of the chemical liquid storage line 12 may be coupled to the chemical liquid pumping device 11.
  • the downstream end of the chemical liquid storage line 12 may be coupled to the chemical liquid injection valve 13.
  • An outer storage space 10p2 may be formed in the chemical storage line 12.
  • the chemical liquid storage line 12 may be a flexible tube.
  • the chemical liquid pumping device 11 is configured to accommodate a chemical liquid in the inner space 10s.
  • the chemical liquid pumping device 11 is configured to be able to pressurize the chemical liquid in the inner space 10s.
  • the chemical liquid pumping device 11 includes a chamber 11a configured to accommodate a chemical liquid therein.
  • the chamber 110 forms an inner space 10s together with the pressurization unit 120.
  • the chemical solution may be stored in the inner space 10s.
  • the chemical liquid pumping device 11 includes a pressurizing unit 11b forming an inner space 10s together with a chamber.
  • the pressurizing unit 11b is configured to be able to pressurize the chemical liquid in the inner space 10s.
  • the pressing unit 11b can pressurize the chemical liquid in the inner space 10s by moving in a predetermined pressing direction. When the chemical solution is being filled into the chamber 11a, the pressing unit 120 may move in a direction opposite to the pressing direction.
  • the chemical liquid pumping device 11 may include a pressing operation unit 11c that provides power to move the pressing unit 11b in the pressing direction.
  • the description of the pressing operation unit 11c is the same as the description of the first embodiment described above.
  • the chemical liquid pumping device 11 may include an inner storage unit 11d forming the inner storage space 10p1.
  • the inner storage unit 11d may extend in a direction facing the pressing unit 11b from the inner surface of the chamber 11a.
  • the inner storage unit 11d may extend in an upstream direction from the inner surface of the chamber 11a.
  • the inner space 10s and the inner storage space 10p1 are connected to each other through an opening at the upstream end of the inner storage unit 11d.
  • the inner storage unit 11d may be integrally formed with the chamber 11a.
  • a storage corresponding groove 11bh may be formed so as to engage with the inner storage 11d.
  • a portion of the pressing surface (the surface facing the inner space 10s) of the pressing unit 11b may be depressed to form a storage corresponding groove 11bh.
  • the storage corresponding groove 11bh may constitute a part of the inner space 10s. Accordingly, the internal space 10s of the chemical liquid pumping device 11 can be efficiently formed.
  • the chemical liquid flow unit 20 is configured to be coupled to the chemical liquid storage unit 10.
  • a guide flow path 20p of the chemical liquid configured to be connected to the other end 10pb of the priming storage space 10p in a state of being coupled to the chemical liquid storage part 10 is formed.
  • the upstream end of the guide flow path 20p and the downstream end of the priming storage space 10p have the chemical liquid injection valve 13 interposed therebetween. Are connected to each other.
  • the downstream end of the guide passage 20p may be connected to the patient connection units 600 and 600 ′ by the user.
  • the coupling member 21 may be configured to be coupled to the chemical liquid injection valve 13.
  • the coupling member 21 is disposed at the upstream end of the chemical liquid flow line 22.
  • an upstream end portion of the guide passage 20p may be formed.
  • the chemical liquid flow line 22 extends from the coupling member 21.
  • the upstream end of the chemical liquid flow line 22 may be coupled to the coupling member 21.
  • the downstream end of the chemical liquid flow line 22 may be coupled to the air filter 23 or the chemical liquid transfer pipe device 24.
  • a guide passage 20p is formed in the chemical liquid flow line 22. That is, a part or all of the guide passage 20p may be formed in the chemical liquid flow line 22.
  • the chemical liquid flow line 22 may be a flexible tube.
  • the chemical liquid injection valve 13 when the coupling member 21 is coupled to the chemical liquid injection valve 13, the chemical liquid injection valve 13 is opened by the coupling member 21 and the other end 10pb of the priming storage space 10p And the guide passage 20p is configured to be connected.
  • the air filter 23 may filter air bubbles (bubbles) in the liquid flowing through the guide passage 20p.
  • the air filter 23 may be configured in combination with a particle filter that filters impurities.
  • An air vent configured to discharge air caught in the air filter 23 to the outside may be formed in the air filter 23.
  • the chemical liquid transfer pipe device 24 is configured to adjust the flow rate of the liquid flowing through the guide passage 20p.
  • the chemical liquid transfer pipe device 24 is formed integrally with the air filter 23, but in an embodiment not shown, the chemical liquid transfer pipe device 24 and the air filter 23 may be configured separately, In this case, the air filter 23 may be disposed in the middle of the chemical liquid flow line 22.
  • the chemical liquid transfer pipe device 24 may include a chemical liquid transfer pipe 24a that limits the hourly flow rate of the chemical liquid (see FIG. 8 ).
  • the chemical liquid transfer pipe 24a has a capillary flow path constituting a part of the guide flow path 20p.
  • the description of the chemical liquid transfer pipe 24a is the same as the description of the chemical liquid transfer pipe 820 described above.
  • the end cap 700 may be configured to be coupled to the front end (ie, the downstream end) of the chemical liquid flow unit 20.
  • the end cap 700 may be disposed at the downstream end of the guide passage 20p.
  • the end cap 700 is configured to be coupled to the downstream end of the chemical liquid transfer pipe device 24.
  • the priming liquid may be filled in the guide passage 20p.
  • the end cap 700 is configured such that air passing through the guide passage 20p and the priming liquid are introduced into the interior.
  • the end cap 700 may be configured to allow air to flow to the outside but prevent the priming liquid from leaking to the outside.
  • a description of an example of a specific configuration of the end cap 700 is the same as the description of the end cap according to the first embodiment described above.
  • the end cap 700 When the liquid for priming is filled in the end cap 700, the end cap 700 may be separated from the chemical liquid flow part 20, and the chemical liquid flow part 20 and the patient connection units 600, 600' can be connected. .
  • FIGS. 2 to 7 are partially cut-away elevational views of the chemical solution injection device 2 according to the second embodiment of the present disclosure, and are views sequentially showing a preparation process of the chemical solution injection device 2.
  • the method of preparing the chemical solution injection may be performed in the order of FIGS. 2 to 7.
  • the method for preparing the chemical solution injection includes a chemical solution storing step and a priming liquid storing step performed after the chemical solution storing step.
  • the method of preparing the chemical solution injection includes a flow path connection step and a priming step performed after the step of storing the priming liquid.
  • the method of preparing the chemical solution injection may include preparing a chemical solution injection device 2 in which the chemical solution storage unit 10 and the chemical solution flow unit 20 are separated from each other.
  • the priming storage space 10p is filled with air.
  • the method for preparing the chemical solution injection includes a chemical solution storing step of filling the chemical solution M1 in the chemical solution storage unit 10 after that.
  • the chemical liquid M1 is introduced into the internal space 10s of the chemical liquid pumping device 11 through the chemical liquid injection valve 13.
  • the syringe X1 filled with the chemical liquid M1 is coupled to the chemical liquid injection valve 13 (for example, the syringe and the chemical liquid injection valve may be in a state in which the syringe and the chemical liquid injection valve press each other by the force of the user, ,
  • the syringe X1 is operated in a state where the syringe and the chemical solution injection valve have structural coupling force to each other), so that the chemical solution M1 in the syringe X1 is filled into the inside of the chemical solution pumping device 11.
  • the chemical solution injection valve 13 is opened.
  • the chemical liquid M1 may flow into the internal space 10s through the priming storage space 10p connecting the chemical liquid injection valve 13 and the internal space 10s.
  • the chemical solution (M1) may be 5FU.
  • the syringe X1 is separated from the chemical solution storage unit 10. With the syringe X1 being separated from the chemical solution injection valve 13, the chemical solution injection valve 13 is closed.
  • the method for preparing the chemical solution injection includes a priming liquid storage step of additionally filling the chemical solution storage unit 10 with a priming liquid M2.
  • the priming liquid M2 is introduced in the direction of the inner space 10s through the chemical liquid injection valve 13.
  • the priming liquid M2 may be filled in the priming storage space 10p.
  • the syringe X2 filled with the priming liquid M2 is coupled to the chemical liquid injection valve 13 (for example, the syringe and the chemical liquid injection valve press each other by the force of the user.
  • the syringe X2 is operated in a state where the syringe and the chemical injection valve are structurally bonded to each other), so that the priming liquid M2 in the syringe X2 is transferred to the priming storage space 10p. Is filled.
  • the chemical solution injection valve 13 is opened.
  • the priming liquid M2 may be saline.
  • the syringe X2 is separated from the chemical solution storage unit 10. With the syringe X2 being separated from the chemical solution injection valve 13, the chemical solution injection valve 13 is closed.
  • the method for preparing the chemical solution injection includes a flow path connection step of coupling the chemical solution storage unit 10 and the chemical solution flow unit 20 to each other.
  • the chemical liquid flow part 20 is coupled to the chemical liquid injection valve 13 to connect the guide flow path 20p of the chemical liquid flow part 20 and the inner space 10s.
  • the chemical solution injection valve 13 and the coupling member 21 may be coupled to each other (see FIG. 12 ).
  • the chemical liquid injection valve 13 is opened.
  • the end cap 700 may be coupled to the downstream end of the chemical liquid flow unit 20, and the chemical liquid flow unit 20 may be provided in a state coupled to the end cap 700 from the beginning ( 8).
  • the method for preparing the chemical solution injection includes a priming step of pressing the chemical solution so that the priming liquid M2 flows along the guide passage 20p.
  • the chemical liquid pumping device 11 pressurizes the inner space 10s so that the priming liquid M2 flows before the chemical liquid M1 along the guide flow path 20p.
  • the priming step includes the step of operating the chemical liquid pumping device 11.
  • the chemical liquid pumping device 11 pressurizes the chemical liquid M1 in the inner space 10s.
  • the operating mechanism of the chemical liquid pumping device of the chemical liquid injection device 1 according to the first embodiment described above may be applied.
  • the chemical liquid pumping device 11 generates gas (for example, carbon dioxide) therein to pressurize the internal chemical liquid M1 by the pressure of the generated gas (refer to arrow P).
  • the user may pressurize a predetermined position of the chemical liquid pumping device (refer to arrow F) to generate the gas so that the pressurizing operation unit 130 starts to operate.
  • the priming liquid M2 is first filled along the guide flow path 20p.
  • the priming liquid M2 is filled up to the end cap 700 along the guide flow path 20p, the priming process is completed, and preparation for injection of the chemical solution is completed.
  • the chemical liquid (M1) may have flowed into the upstream side of the chemical liquid flow part (20), or still flow into the chemical liquid flow part (20). It may not be in a state.
  • the end cap 700 is separated from the chemical solution flow unit 20, and the patient connection units 600 and 600' are connected to the chemical solution flow unit 20, and the chemical solution injection step You can proceed.
  • the chemical injection step first, the priming liquid may be introduced into the patient's body, and the chemical liquid flowing following the priming liquid may be introduced into the patient's body.
  • FIG. 8 is a cross-sectional view showing a chemical solution injection device 2'according to a modified example of the second embodiment.
  • 9 and 10 are perspective views of the chemical solution injection device 2'of FIG. 8, and FIG. 9 shows a state separated into a chemical solution storage unit 10 and a chemical solution flow unit 20, and FIG. 10 is a chemical solution storage unit. It shows a state in which (10) and the chemical liquid flow part (20) are combined with each other.
  • the chemical solution storage line 12 is formed longer than the exemplary embodiment of FIG. 2. The longer the chemical storage line 12 is, the more advantageous it is to form the priming storage space 10p larger.
  • FIG. 11 is a cross-sectional view showing the state of the chemical solution injection valve 13 in FIG. 9.
  • 12 is a cross-sectional view showing the state of the chemical solution injection valve 13 in FIG. 10.
  • part E is an elevation view of the valve part 13b in a direction in which the protrusion 21a presses the valve part 13b.
  • the chemical injection valve 13 may include a valve casing 13a and a valve portion 13b disposed inside the valve casing 13a.
  • the valve casing 13a may form a space for accommodating the valve part 13b therein, but may form an opening at the front end.
  • the front end of the valve part 13b may be exposed through the opening of the valve casing 13a.
  • the valve casing 13a may include a first part 13a1 and a second part 13a2 that are assembled to each other.
  • the first part 13a1 may constitute a downstream portion forming the opening, and the second part 13a2 may constitute an upstream portion coupled to the chemical liquid storage line 12.
  • the valve portion 13b may be configured to be opened in a pressed state from the front end (ie, a pressed state from the downstream side) and closed in a state in which the pressing is released.
  • the valve part 13b may be formed of a flexible material such as rubber.
  • a hole (eg, a slit) 13bh that opens in a pressed state is formed in the valve portion 13b. By closing the hole 13bh, the downstream end of the priming storage space 10p is blocked (see Fig. 11). By opening the hole 13bh, the priming storage space 10p and the guide flow path 20p are connected to each other through the hole 13bh (see FIG. 12).
  • the protrusion 21a of the coupling member 21 may be formed to protrude in the upstream direction.
  • the protrusion 21a may be inserted into the chemical solution injection valve 13 through the opening of the valve casing 13a.
  • the front end (ie, the downstream end) of the valve casing 13a may cover the outer peripheral surface of the protrusion 21a.
  • the screw formed on the outer peripheral surface of the front end portion of the valve casing 13a may be configured to be coupled with the screw formed on the inner peripheral surface of the upstream end portion of the coupling member 21.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne, selon un mode de réalisation, un dispositif d'injection de solution chimique qui comprend : une partie de stockage de solution chimique qui est conçue pour former un espace interne destiné à stocker une solution chimique et comprend un espace de stockage d'amorçage s'étendant à partir de l'espace interne, une extrémité de l'espace de stockage d'amorçage étant conçue pour être positionnée au niveau du point de liaison entre l'espace de stockage d'amorçage et l'espace interne ; et une partie d'écoulement de solution chimique qui est conçue pour être couplée à la partie de stockage de solution chimique et dans laquelle est formé un canal de fluide de guidage pour une solution chimique, le canal de fluide de guidage étant conçu pour être relié à l'autre extrémité de l'espace de stockage d'amorçage dans un état dans lequel la partie d'écoulement de solution chimique est couplée à la partie de stockage de solution chimique.
PCT/KR2020/014153 2019-10-18 2020-10-16 Dispositif d'injection de solution chimique et procédé de préparation d'injection de solution chimique WO2021075900A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2022522596A JP2022553172A (ja) 2019-10-18 2020-10-16 薬液注入装置及び薬液注入準備方法
CN202080072182.7A CN114585401A (zh) 2019-10-18 2020-10-16 药液注入装置及药液注入准备方法
US17/767,562 US20240058549A1 (en) 2019-10-18 2020-10-16 Medicinal liquid injection apparatus and medicinal liquid injection preparation method

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2019-0130170 2019-10-18
KR20190130170 2019-10-18
KR10-2020-0009361 2020-01-23
KR1020200009361A KR102373991B1 (ko) 2019-10-18 2020-01-23 약액 주입 장치 및 약액 주입 준비 방법

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KR20230024555A (ko) * 2021-08-12 2023-02-21 김용현 약액 주입 장치

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KR100463636B1 (ko) * 2002-08-09 2004-12-30 김용년 액체 주입용 튜브의 캡
KR20100113256A (ko) * 2009-04-13 2010-10-21 (주)이화프레지니우스카비 약물 충전 및 흐름제어장치 그리고 이를 구비한 약물주입장치
KR20150029283A (ko) * 2013-09-10 2015-03-18 김용무 내부 필터를 구비한 모세관 장치 및 이를 구비한 주사액 주입장치
JP2016501109A (ja) * 2012-12-19 2016-01-18 アニマス・コーポレイション 自動プライミングを可能にする医療用注入システム
KR20190044478A (ko) * 2017-10-20 2019-04-30 김용현 위험 약액 주입용 플러싱 장치 및 위험 약액 주입 장치

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100463636B1 (ko) * 2002-08-09 2004-12-30 김용년 액체 주입용 튜브의 캡
KR20100113256A (ko) * 2009-04-13 2010-10-21 (주)이화프레지니우스카비 약물 충전 및 흐름제어장치 그리고 이를 구비한 약물주입장치
JP2016501109A (ja) * 2012-12-19 2016-01-18 アニマス・コーポレイション 自動プライミングを可能にする医療用注入システム
KR20150029283A (ko) * 2013-09-10 2015-03-18 김용무 내부 필터를 구비한 모세관 장치 및 이를 구비한 주사액 주입장치
KR20190044478A (ko) * 2017-10-20 2019-04-30 김용현 위험 약액 주입용 플러싱 장치 및 위험 약액 주입 장치

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230024555A (ko) * 2021-08-12 2023-02-21 김용현 약액 주입 장치
WO2023018248A3 (fr) * 2021-08-12 2023-09-28 김용현 Appareil d'injection de liquide médicinal
KR102599610B1 (ko) 2021-08-12 2023-11-08 김용현 약액 주입 장치

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