WO2015199360A1 - Injecteur de médicament pour l'expérimentation de la toxicité par inhalation - Google Patents

Injecteur de médicament pour l'expérimentation de la toxicité par inhalation Download PDF

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Publication number
WO2015199360A1
WO2015199360A1 PCT/KR2015/005825 KR2015005825W WO2015199360A1 WO 2015199360 A1 WO2015199360 A1 WO 2015199360A1 KR 2015005825 W KR2015005825 W KR 2015005825W WO 2015199360 A1 WO2015199360 A1 WO 2015199360A1
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Prior art keywords
drug
injection pipe
case
supply unit
guide
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PCT/KR2015/005825
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English (en)
Korean (ko)
Inventor
이배
황인철
Original Assignee
주식회사 두배시스템
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Publication of WO2015199360A1 publication Critical patent/WO2015199360A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/267—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the respiratory tract, e.g. laryngoscopes, bronchoscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D1/00—Surgical instruments for veterinary use
    • A61D1/02—Trocars or cannulas for teats; Vaccination appliances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath

Definitions

  • the present invention can be used to perform inhalation toxicity experiments using laboratory animals in the laboratory and administration of inhalation toxicity experiments that can spray a liquid or powder drug into the lungs of the experimental animals in a vaporized state. It is about the flag.
  • Such drug administration is disclosed in Korean Patent Publication No. 10-1259154.
  • the above-mentioned publication discloses a technique for accurately administering a certain amount of liquid chemical solution to the throat of an animal in the form of a drop while a visual confirmation of an image of the throat of the animal by a video camera.
  • the drug is supplied to the throat of the animal in the form of a drop, so that the drug cannot be injected into the lungs or uniformly, and thus the precision of the experiment is inferior and it is not suitable for the inhalation toxicity test. There is a problem.
  • test subject needs to supply the drug uniformly and directly to the lungs through the airway of the animal, but when the test animal (Rat) is small, the airway size of the test subject animal is very small, about 1.3 mm. There is a problem that it is difficult to inject the correct amount of drug in position.
  • the conventional drug injector can be injected into the throat of the animal in the form of a drop, but there is a problem that it is difficult to inject the drug ( ⁇ ) of the powder (fine powder such as powder) directly into the animal's lungs.
  • an object of the present invention is to inhale by spraying a drug in the liquid or powder state to the lungs of the experimental mouse in a relatively uniform vaporization state.
  • another object of the present invention is the inhalation that can easily inject the drug evenly through the animal's lungs even through the small airway of the animal, such as rat rats significantly smaller rats (Rat) To provide a drug administration device for toxicity experiments.
  • the present invention provides a case provided with a guide tube, the photographing unit installed in the case and the guide tube, compressed air supply unit for supplying compressed air, drug supply unit for supplying a drug for experimentation
  • compressed air supply unit for supplying compressed air
  • drug supply unit for supplying a drug for experimentation
  • An air spray pipe connected to the compressed air supply unit and disposed inside the guide tube, a drug spray pipe connected to the drug supply unit and disposed inside the guide tube, and installed inside the case;
  • an inhalation toxicity experiment drug injector including a spray pipe moving portion protruding the tip of the drug injection pipe to the outside of the guide tube.
  • the injection pipe moving unit includes a drive source, a pinion gear rotated by the drive source, a rack gear moved by the pinion gear, a moving member coupled to the rack gear and coupled to the air injection pipe and the drug injection pipe. Can be.
  • the photographing unit is preferably made of a bore scope.
  • the drug injection pipe is preferably disposed inside the air injection pipe.
  • the present invention provides a case provided with a guide tube, the photographing unit is installed in the case and the guide tube, the compressed air supply unit installed in the case, the compressed air supply unit and the drug supply unit for supplying the experimental drug, and the drug supply unit It is connected with and provides an inhalation toxicity experiment drug injector comprising a drug injection tube disposed inside the guide tube.
  • the compressed air supply unit is a drive source installed in the case, a rotary screw rotated by the drive source, a guide installed in the case and arranged in parallel with the rotary screw, a pressing member moving by the rotary screw along the guide;
  • a piston installed in the case and coupled to the pressure member, a cylinder into which the piston is fitted, coupled to a front end of the cylinder to supply the compressed air inside the cylinder to the drug supply unit, and the drug contained in the drug supply unit is It is preferable to include a first check valve for blocking the flow into the cylinder, and a second check valve coupled to one side of the cylinder for introducing external air into the cylinder.
  • the drug injection pipe is disposed such that a tip thereof protrudes outward.
  • the drug supply unit may be connected to the drug injection pipe and includes a drug container for accommodating the powdered drug, and a vibration generating unit installed in the drug container to prevent the powdered drug from agglomerating or sticking to the wall surface of the drug container.
  • the present invention is provided with a case provided with a guide tube, the photographing unit is installed in the case and the guide tube, the drug supply unit is installed in the case for supplying an experimental drug, connected to the drug supply unit and disposed inside the guide tube Including a drug injection tube, the drug injection tube provides an inhalation toxicity test drug injector provided with a small diameter or a small inlet diameter portion provided with an inner diameter of the tip portion compared to the inner diameter of the other portion.
  • the drug supply unit is a drive source, a rotating screw rotated by the drive source, a guide installed in the case and arranged in parallel with the rotating screw, a pressing member moving by the rotating screw along the guide, the case is installed in the It is preferable to include a piston in close contact with the pressing member, and a cylinder in which the piston is fitted and connected to the drug injection pipe.
  • the drug injection pipe is disposed such that a tip thereof protrudes outward.
  • Such an embodiment of the present invention has the effect of increasing the precision of the inhalation toxicity test by spraying the drug in the liquid or powder state in a relatively uniform vaporization state to the lung or the position adjacent to the lungs of the experimental mouse.
  • the distal end of the drug injection tube protrudes to the outside of the guide tube, and the vaporized drug is injected through the small airway of the animal, such as an experimental rat (Rat), in which the animal of the test object is significantly smaller.
  • Rat experimental rat
  • FIG. 1 is an external view showing a drug injector for inhalation toxicity test to explain a first example of an embodiment of the present invention.
  • FIG. 2 is a sectional view of the present invention, taken along a line II-II of FIG. 1.
  • FIG. 3 is a cross-sectional view of the air injection pipe, the drug injection pipe, and the injection pipe moving part of FIG.
  • FIG. 4 is an exploded perspective view showing the main part of FIG.
  • FIG. 5 is a view showing a combined state of the air injection pipe and the drug injection pipe to explain a first example of an embodiment of the present invention.
  • FIGS. 6 and 7 are perspective views showing the inhalation toxicity test drug injector to explain a second example of the embodiment of the present invention.
  • FIG. 8 is a cross-sectional view taken along line VIII-VIII of FIG. 7.
  • FIG. 9 is a view showing a drug supply unit for supplying a drug using a powdered drug to explain a second example of an embodiment of the present invention.
  • FIG. 10 is a view for explaining the operation of the drug supply to explain a second example of an embodiment of the present invention.
  • FIG. 11 is a perspective view showing a drug injector for inhalation toxicity test to explain the third embodiment of the embodiment of the present invention.
  • FIG. 12 is a cross-sectional view taken along the line II-XIII of FIG. 11.
  • FIG. 13 is an enlarged view of a drug injection tube that is a main part of FIG. 12.
  • FIG. 14 is a view for explaining another example of FIG. 13.
  • FIG. 1 is a perspective view for explaining a first example of an embodiment of the present invention
  • Figures 2 and 3 is a cross-sectional view of the cut II-II of Figure 1
  • Figure 4 is an exploded perspective view showing the main part of Figure 2 exploded Inhalation toxicity test drug injector is shown.
  • the case 1 is provided with a space therein, and the guide tube 1a is arranged to be thin and long toward the tip end side.
  • the case 1 is preferably made of a form that allows the user to insert the guide tube 1a into the airway of the laboratory animal (for example, an animal such as a rat) by hand.
  • Guide tube (1a) may be made integrally with the case (1) or a separate part is coupled to the case (1).
  • Guide tube (1a) is preferably made long and thin enough to be inserted into the airway side of the experimental rat.
  • the photographing unit 3 may be disposed in the case 1 and the guide tube 1a.
  • the imaging unit 3 may be a borescope (Borescope).
  • Boescope Borescope
  • the bore scope 3 is a bore scope.
  • an optical tube T see FIGS. 3 and 4 of the tip of the bore scope may be disposed inside the guide tube 1a.
  • the compressed air supply unit 5 is a device capable of storing compressed air or compressing air.
  • the compressed air supply unit 5 may be connected to the air injection pipe 9 to supply compressed air.
  • the compressed air supply unit 5 is installed outside the case 1 may be connected to the air injection pipe (9) by a separate pipe.
  • Drug supply unit 7 is a device for supplying an experimental drug ( ⁇ ) can be made in the shape of a syringe.
  • the drug supply unit 7 may mainly contain a liquid.
  • Drug supply unit 7 may be connected to the drug injection pipe (11) in a pipeline.
  • the drug supply unit 7 may also be installed outside the case 1.
  • the drug supply unit 7 may supply the drug injection pipe 11 to an amount set by a separate driving device (not shown).
  • the drug supply unit 7 may supply the experimental drug ( ⁇ ) to the drug injection pipe 11 by the amount set by the control of a separate control device (not shown).
  • the air injection pipe 9 is arrange
  • the drug injection pipe 11 is also preferably disposed inside the guide pipe (1a). More preferably in the embodiment of the present invention, the air injection pipe (9) is disposed inside the guide pipe (1a), the drug injection pipe (11) is preferably arranged inside the air injection pipe (9). That is, the air injection pipe (9) and the drug injection pipe (11) constitute a double pipe, the outer pipe serves as the air injection pipe (9), the inner pipe preferably serves as the drug injection pipe (11). (See FIG. 5).
  • the injection pipe moving part 13 is installed inside the case 1 and may serve to protrude the tip portions of the air injection pipe 9 and the drug injection pipe 11 to the outside of the guide pipe 1a.
  • the injection pipe moving part 13 includes a drive source 15, a pinion gear 17, a rack gear 19, and a moving member 21.
  • the drive source 15 may be made of a motor or the like.
  • the pinion gear 17 rotates by receiving the driving force by the driving source 15.
  • the rack gear 19 is engaged with the pinion gear 17 to move along the longitudinal direction of the guide tube 1a as the pinion gear 17 rotates.
  • the moving member 21 is coupled to the rack gear 19, the air injection pipe 9 and the drug injection pipe 11 is integrally coupled.
  • the moving member 21 is integrally coupled to the air injection pipe 9, and the drug injection pipe 11 is fixed to the inner diameter of the air injection pipe 9. Accordingly, the air injection pipe 9 and the drug injection pipe 11 are fixed to the moving member 21.
  • the moving member 21 can move a predetermined section along the longitudinal direction of the guide tube (1a) in the case (1). That is, when the drive source 15 is driven, the pinion gear 17 rotates, and the rack gear 19 moves in accordance with the rotation of the pinion gear 17. When the rack gear 19 is moved, the movable member 21 is also moved. When the moving member 21 moves, the air injection pipe 9 and the drug injection pipe 11 also move together, and the tip portions of the air injection pipe 9 and the drug injection pipe 11 protrude outward of the guide pipe 1a. It may be stored in the interior of the guide tube (1a).
  • the researcher inserts the guide tube 1a through the airway of the laboratory animal while holding the case 1.
  • the tube T of the imaging unit 3, such as a borescope extends inside the guide tube 1a, the state of the airway of the laboratory animal is photographed. Therefore, the researcher can externally check the inside of the airway of the laboratory animal.
  • the researcher operates the switch (not shown) to drive the driving source 15.
  • the pinion gear 17 is rotated by the driving force of the drive source 15.
  • the rack gear 19 moves to the tip end side of the guide pipe 1a.
  • the injection pipe moving part 13 also moves in the same direction.
  • the injection pipe moving part 13 is integrally coupled with the air injection pipe 9 and the drug injection pipe 11, so that the air injection pipe 9 and the drug injection pipe 11 also move in the same direction.
  • This condition may be such that the air injection pipe 9 and the drug injection pipe 11 are inserted into or at least close to the lung.
  • the compressed air is transferred from the compressed air supply unit 5 to the air injection pipe 9.
  • the amount of drug set in the drug injection pipe 11 is supplied to the drug injection pipe 11.
  • the air is injected from the air injection pipe (9) while the drug () ⁇ ) coming out through the drug injection pipe 11 in the form of vaporization ( ⁇ ) while supplying the drug to the lung side.
  • the drug then spreads evenly throughout the lungs of the experimental animal. In this way, if the drug in the vaporized state spreads uniformly in the lungs of the experimental animal, the accuracy of the experiment can be improved.
  • the drug supply unit 7 may be used to accommodate the liquid drug.
  • FIGS. 6 and 7 are perspective views for explaining a second example of an embodiment of the present invention, showing an inhalation toxicity test drug injector.
  • components having the same structure and function as in the first example of the above-described embodiment are denoted by the same reference numerals and replaced by the description of the above-described example.
  • the second example of the embodiment of the present invention describes a structure suitable for conducting inhalation toxicity experiments of laboratory animals when the drug is made into a powder state.
  • the case 1 is provided with a space therein. And the guide tube 1a is provided in the front-end
  • the same as the first example of the above-described embodiment can also be used for the imaging section 3. Therefore, the detailed description of the case 1 and the photographing unit 3 will be replaced by the above description.
  • the compressed air supply unit 23 of the second example of the embodiment of the present invention as shown in Figure 8, the drive source 29, the rotating screw 31, the guide 33, the pressing member 35, the piston 37 ), A cylinder 39, a first check valve 41 (shown in FIGS. 9 and 10), and a second check valve 43 (shown in FIGS. 9 and 10).
  • the drive source 29 may be installed inside the case 1. It is preferable that the drive source 29 consists of being able to control the rotation speed by a control apparatus (not shown) like a step motor.
  • the rotating screw 31 may be coupled to a rotating shaft (not shown) of the driving source 29 to receive the driving force of the driving source 29 to rotate.
  • Rotating screw 31 is preferably arranged horizontally with respect to FIG. And the rotating screw 31 may be provided with a thread on the outer peripheral surface.
  • the guide 33 is disposed in the case 1 in a direction parallel to the rotating screw 31.
  • the guide 33 is preferably formed in pairs and may be made of a rod-like member (see FIGS. 6 and 7).
  • the pressing member 35 is arranged to move along the guide 33.
  • the pressing member 35 may be provided with a through hole (not shown), and a screw groove (not shown) may be provided inside the hole. And the pressing member 35 is coupled to the thread provided on the outer peripheral surface of the screw groove provided in the hole and the rotary screw 31. Therefore, as the rotating screw 31 rotates, it can move along the guide 33.
  • the piston 37 is coupled to the pressing member 35 may move in a direction parallel to the guide 33 as the pressing member 35 moves (forward or backward).
  • the cylinder 39 may be filled with air therein and the piston 37 may be fitted therein. Therefore, the piston 37 may move along the inside of the cylinder 39.
  • the piston 37 and the cylinder 39 is preferably made of the same structure as a conventional syringe. Therefore, the piston 37 may move the inside of the cylinder 39 to compress the air inside the cylinder 39 to produce compressed air.
  • the cylinder 39 may be provided with a fixing portion 1b for fixing the cylinder 39 to the upper portion of the case 1 by fitting.
  • the fixing part 1b may be provided with an elastic part in a semicircular shape to fix the cylinder 39 by fitting. Such a researcher can easily replace and use the cylinder 39 to the fixing part 1b, as needed.
  • the first check valve 41 and the second check valve 43 may be provided in the cylinder 39, and may also be installed in a separate connecting member 45 connected to the front end of the cylinder 39. .
  • the first check valve 41 may be disposed at the front end of the connecting member 45, and the second check valve 43 may be disposed at the side of the connecting member 43 (shown in FIGS. 8 and 9).
  • the first check valve 41 may supply the compressed air inside the cylinder 39 to the drug supply unit 25.
  • the first check valve 41 serves to block the drug ( ⁇ ) accommodated in the drug supply unit 25 is introduced into the cylinder (39).
  • the second check valve 43 is coupled to the outer circumferential side of the cylinder 39 and serves to introduce external air into the cylinder 39, and the internal air of the cylinder 39 is the drug supply unit 25 described above. When it is supplied to, it blocks the inflow of outside air.
  • the first check valve 41 is opened when the air in the cylinder 39 is injected into the drug supply unit 25, and closed when the air is sucked into the cylinder 39, and the second check valve is closed. 43 is closed when injecting air in the cylinder 39 into the drug supply unit 25, and can be opened when sucking air into the cylinder 39.
  • the drug supply unit 25 may include a drug container 47 and a vibration generating unit 49.
  • Drug barrel 47 is preferably coupled to the case 1 in an inclined state.
  • One side of the drug container 47 is provided with a drug inlet 47a.
  • Drug barrel 47 may be accommodated in the form of powder or fine powder ( ⁇ ).
  • the medicine container 47 is connected to the side of the first check valve 41 of the compressed air supply unit 23 to allow the compressed air to flow into the medicine container 47.
  • Vibration generating unit 49 serves to prevent the drug ( ⁇ ⁇ ) in the form of powder accommodated in the drug container 47 to stick to the wall or to agglomerate with each other.
  • the vibration generator 49 may generate vibration by a separate driving source (not shown), and the vibration member (not shown) may be achieved by a researcher driving a separate switch (not shown). have.
  • Drug injection pipe 27 is connected to the drug supply unit 25 is disposed inside the guide tube (1a). And the drug injection pipe 27 is preferably arranged so that the front end protrudes to the outside of the guide pipe (1a).
  • the investigator inserts a guide tube 1a into the airway of the laboratory animal.
  • the researcher approaches the drug injection pipe 27 to a position close to the lung of the experimental animal while watching the captured image of the imaging unit 3.
  • the investigator then activates a switch (not shown) to drive the inhalation toxicity tester.
  • the rotary screw 31 rotates. Then, the rotating screw 31 rotates to move the pressing member 35.
  • the pressing member 35 compresses the air in the cylinder 39 by pressing the piston 37 while moving along the guide 33. At this time, the air compressed by the piston 37 in the cylinder 39 is supplied to the drug container 47 of the drug supply unit 25 while the first check valve 41 is opened. At this time, the second check valve 43 maintains the closed state.
  • the powdered drug in the drug container 47 is discharged through the drug injection pipe 27 and scattered in a state equivalent to the vaporized state. Therefore, the drug can be uniformly supplied to the lungs of the experimental animal.
  • the control device controls the drive source 29 to rotate in reverse.
  • the pressing member 35 is then returned to its original position.
  • the first check valve 41 is closed to block the drug in the medicine container 47 from flowing into the cylinder 39.
  • the second check valve 43 is opened to introduce external air into the cylinder 39.
  • the second example of the embodiment of the present invention may uniformly supply the drug to the lungs of the experimental animal under conditions similar to the vaporization state even when the drug is made of powder.
  • the set drug is injected into the vaporized state to be injected relatively uniformly into the lungs of the experimental animal, as well as a part of the drug injection tube 27 protrudes out of the guide tube 1a.
  • a small laboratory rat (Rat) can be injected by evaporating the drug into the lungs through the airways.
  • Inhalation toxicity experiment drug injector of the embodiment of the present invention can be injected into the lungs of the animal evenly in the inhalation toxicity test using the animal can increase the reliability of the experimental results.
  • FIG. 11 is a perspective view illustrating a third example of an embodiment of the present invention
  • FIG. 12 is a cross-sectional view of the II-XII of FIG. 11 and illustrates a drug injector for inhalation toxicity experiment.
  • constituent elements having the same structure and function as in the first example and the second example of the above-described embodiment are denoted by the same reference numerals and replaced with the description of the above-described example.
  • the third example of the embodiment of the present invention describes a structure suitable for the inhalation toxicity test of the experimental animal by spraying in a vaporized state when the drug is in a liquid state.
  • Drug supply unit 51 of the embodiment of the present invention includes a drive source 55, a rotating screw 57, a guide 59, a pressing member 61, a piston 63, and a cylinder (65).
  • the drive source 55 may be installed inside the case 1 and may be controlled by a control device (not shown). It is preferable that the drive source 55 consists of a motor which can control rotation speed like a step motor.
  • Rotating screw 57 is coupled to the rotation axis (not shown) of the drive source 55 may be rotated by receiving the driving force of the drive source (55).
  • Rotating screw 57 is preferably arranged horizontally with respect to FIG. And the rotating screw 57 may be provided with a thread on the outer peripheral surface.
  • the guide 59 is disposed in the case 1 in a direction parallel to the rotating screw 57.
  • Guide 59 is preferably made in pairs and may be made of a member such as a rod.
  • the pressing member 61 is arranged to move along the guide 59.
  • the pressing member 61 may be provided with a through hole (not shown), and a screw groove (not shown) may be provided inside the hole.
  • the pressure member 61 is coupled to a screw groove provided in this hole and a screw thread provided on the outer circumferential surface of the rotating screw 57. Therefore, as the rotating screw 57 rotates, it can move along the guide 59.
  • the piston 63 is coupled to the pressing member 35 so that the piston 63 may move in a direction parallel to the guide 59 as the pressing member 61 moves (forward or backward).
  • Cylinder 65 may be filled with a drug ( ⁇ ⁇ ) of the liquid inside and the piston 63 is fitted. Therefore, the piston 63 may move along the inside of the cylinder 65.
  • the piston 63 and the cylinder 65 is preferably made of a structure such as a conventional syringe. Therefore, while the piston 63 moves in the cylinder 65, the liquid drug can be discharged to the drug injection pipe 53 side above a predetermined pressure.
  • the cylinder 65 may be provided with a fixing portion 1b for fixing the cylinder 65 to the upper portion of the case 1 by fitting.
  • the fixing part 1b may be provided with an elastic part in a semicircular shape to fix the cylinder 65 by fitting.
  • the fixing part 1b can be easily replaced by using a cylinder 65 containing other kinds of drugs as necessary.
  • a connecting pipe line 67 may be connected to the front end portion of the cylinder 65, and the drug injection pipe 53 may be connected to the connecting pipe line 67.
  • the diameter of the connection pipe 67 is preferably larger than the diameter of the drug injection pipe (53).
  • the connecting pipe line 67 is connected to the cylinder 65 in which the liquid drug is received, and the drug injection pipe 53 is connected to the connecting pipe line 67. It is not possible to have a structure in which the drug injection pipe 53 is directly connected to the cylinder 65 containing the liquid drug.
  • the drug injection pipe 53 is disposed to protrude outward from the guide pipe 1a.
  • the drug injection tube 53 protrudes out of the guide tube 1a so that the airway is also very small when the size of the laboratory animal is small, and thus the drug injection tube 53 is moved to a position adjacent to the lung of the laboratory animal. Is to insert.
  • a small diameter portion 69 is provided at the distal end portion.
  • the inner diameter of the small diameter portion 69 is preferably made smaller than the inner diameter of the other portion of the drug injection pipe (53).
  • the third example of this embodiment of the present invention may play a role in which the liquid drug with the pressure is scattered in the vaporized state while passing through the small diameter portion 69 of the drug injection pipe 53.
  • the air inlet hole 71 may be installed on the outer circumferential surface of the drug injection pipe 53.
  • the air inlet hole 71 serves to introduce external air when the drug of the high pressure liquid is injected from the drug injection pipe 53. Therefore, the liquid drug injected through the drug injection pipe 53 may be injected in a vaporized state by mixing with air.
  • the investigator inserts a guide tube 1a into the airway of the laboratory animal.
  • the researcher approaches the drug injection tube 53 to a position close to the lung of the laboratory animal while viewing the image photographed by the imaging unit 3.
  • the investigator then activates a switch (not shown) for the inhalation toxicity tester.
  • control device controls the drive source 55 to rotate the rotating screw 57. Then, the rotating screw 57 rotates to move the pressing member 61.
  • the pressing member 61 presses the piston 63 while moving along the guide 59 to push the drug in the liquid phase inside the cylinder 65 above a predetermined pressure.
  • the liquid drug in the cylinder 65 is discharged through the drug injection pipe 53.
  • the drug discharged through the drug injection pipe 53 is sprayed in the evaporated state passing through the large diameter of the drug injection pipe 53, passing through the small diameter portion (69).
  • the air inlet hole 71 in the drug injection pipe 53 If there is an air inlet hole 71 in the drug injection pipe 53, the air is introduced through the air inlet hole 71 while spraying the drug in the vaporized state. Therefore, the drug can be uniformly supplied to the lungs of the experimental animal.
  • the liquid drug ( ⁇ ) is sprayed in a vaporized state to inject relatively uniformly into the lungs of the experimental animal, as well as a part of the drug injection tube 53 is the outside of the guide tube (1a)
  • the drug can be injected by evaporating the drug into the lungs through the airway of a small lab rat to the lungs.
  • Inhalation toxicity experiment drug injector of the embodiment of the present invention can be injected into the lungs of the animal evenly in the inhalation toxicity test using the animal can increase the reliability of the experimental results.

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  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un injecteur de médicament destiné à une expérimentation de toxicité par inhalation, pouvant être utilisé pour la mise en œuvre d'une expérimentation de toxicité par inhalation à l'aide d'une souris expérimentale dans un laboratoire et apte à pulvériser, dans un état vaporisé, un médicament sous forme de liquide ou de poudre, dans les poumons de la souris expérimentale. L'injecteur de médicament destiné à une expérimentation de toxicité par inhalation de la présente invention comprend : un boîtier dans lequel est prévu un tube de guidage ; une unité de prise de vues disposée dans le boîtier et le tube de guidage ; une unité d'alimentation en air comprimé permettant de fournir de l'air comprimé ; une unité d'alimentation en médicament permettant de fournir un médicament expérimental ; un tube d'injection d'air relié à l'unité d'alimentation en air comprimé et disposé à l'intérieur du tube de guidage ; un tube d'injection de médicament relié à l'unité d'alimentation en médicament et disposé à l'intérieur du tube de guidage ; et une unité de déplacement de tube d'injection prévue à l'intérieur du boîtier de manière à faire en sorte que les parties d'extrémité avant du tube d'injection d'air et du tube d'injection de médicament fassent saillie vers l'extérieur du tube de guidage.
PCT/KR2015/005825 2014-06-25 2015-06-10 Injecteur de médicament pour l'expérimentation de la toxicité par inhalation WO2015199360A1 (fr)

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KR10-2014-0078441 2014-06-25
KR1020140078441A KR101594596B1 (ko) 2014-06-25 2014-06-25 흡입독성실험용 약물투여기

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CN110623771A (zh) * 2019-10-12 2019-12-31 中国科学院深圳先进技术研究院 一种可步进的给药装置
CN116439872A (zh) * 2023-06-16 2023-07-18 内蒙古美羊牧业科技有限公司 一种疫苗雾化装置

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KR102037858B1 (ko) * 2018-02-13 2019-10-29 김권태 압력 감지식 점적기
KR102202595B1 (ko) * 2019-03-14 2021-01-13 고려대학교 산학협력단 흡입 실험을 위한 삽관 및 영상 장치

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CN110623771A (zh) * 2019-10-12 2019-12-31 中国科学院深圳先进技术研究院 一种可步进的给药装置
CN116439872A (zh) * 2023-06-16 2023-07-18 内蒙古美羊牧业科技有限公司 一种疫苗雾化装置
CN116439872B (zh) * 2023-06-16 2023-08-22 内蒙古美羊牧业科技有限公司 一种疫苗雾化装置

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KR101594596B1 (ko) 2016-02-16

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