WO2021015465A1 - 콘택트렌즈 및 이를 제조하기 위한 몰드 - Google Patents
콘택트렌즈 및 이를 제조하기 위한 몰드 Download PDFInfo
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- WO2021015465A1 WO2021015465A1 PCT/KR2020/009084 KR2020009084W WO2021015465A1 WO 2021015465 A1 WO2021015465 A1 WO 2021015465A1 KR 2020009084 W KR2020009084 W KR 2020009084W WO 2021015465 A1 WO2021015465 A1 WO 2021015465A1
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- WIPO (PCT)
- Prior art keywords
- drug
- contact lens
- mold
- cover member
- storage structure
- Prior art date
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
- B29D11/00009—Production of simple or compound lenses
- B29D11/00038—Production of contact lenses
- B29D11/00096—Production of contact lenses for delivering compositions, e.g. drugs to the eye
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C33/00—Moulds or cores; Details thereof or accessories therefor
- B29C33/0061—Moulds or cores; Details thereof or accessories therefor characterised by the configuration of the material feeding channel
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C33/00—Moulds or cores; Details thereof or accessories therefor
- B29C33/38—Moulds or cores; Details thereof or accessories therefor characterised by the material or the manufacturing process
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
- B29D11/00009—Production of simple or compound lenses
- B29D11/00038—Production of contact lenses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
- B29D11/00009—Production of simple or compound lenses
- B29D11/00317—Production of lenses with markings or patterns
- B29D11/00326—Production of lenses with markings or patterns having particular surface properties, e.g. a micropattern
- B29D11/00336—Production of lenses with markings or patterns having particular surface properties, e.g. a micropattern by making depressions in the lens surfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
- B29D11/00009—Production of simple or compound lenses
- B29D11/0048—Moulds for lenses
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- C08L33/04—Homopolymers or copolymers of esters
- C08L33/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
- C08L33/062—Copolymers with monomers not covered by C08L33/06
- C08L33/066—Copolymers with monomers not covered by C08L33/06 containing -OH groups
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
- C09D133/04—Homopolymers or copolymers of esters
- C09D133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
- C09D133/062—Copolymers with monomers not covered by C09D133/06
- C09D133/066—Copolymers with monomers not covered by C09D133/06 containing -OH groups
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- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
- G02C7/047—Contact lens fitting; Contact lenses for orthokeratology; Contact lenses for specially shaped corneae
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
- G02C7/049—Contact lenses having special fitting or structural features achieved by special materials or material structures
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C2202/00—Generic optical aspects applicable to one or more of the subgroups of G02C7/00
- G02C2202/24—Myopia progression prevention
Definitions
- the present technology relates to a contact lens and a mold for manufacturing the same.
- a contact lens is a lens that refracts light incident on the eye to correct vision. Unlike glasses, it means that it is mounted on the front of the eye, mainly on the cornea. Most contact lenses are used to correct vision because they can correct refractive errors such as myopia, astigmatism, and farsightedness, and are commonly used when you do not want to wear glasses cosmetically, but glasses cannot obtain sufficient vision correction effect.
- Dry eye syndrome is a phenomenon in which the tear itself or one component of the tear is insufficient, or the tear film is excessively evaporated, so that the tear film does not exhibit sufficient lubricating action on the eyeball surface and the eyeball surface becomes dry. Therefore, it may not be possible to wear contact lenses due to severe irritation to the eyes.
- patients with various diseases including eye diseases, generally provide drugs to the eye through eye drops.
- the eye drops must be periodically injected, and even if the eye drops are injected, they are discharged again as tears after the injection, reducing the effect of the drug.
- This embodiment is to solve such a problem, one of the problems to be solved by this embodiment is to provide a contact lens for improving dry eye syndrome by placing a tear storage structure on the surface of the contact lens in contact with the eye. Another one of the problems to be solved by the embodiment is to provide a contact lens capable of continuously providing drugs to a user through a contact lens.
- a contact lens includes: a vision correction lens unit positioned at the center of the contact lens to refract light; And a tear storage structure in which a plurality of tears are stored radially from the center of the contact lens, wherein the tear storage structure includes: a concave structure formed at a first depth in the contact lens to store the introduced tears.
- a contact lens includes: a vision correction lens unit positioned at the center of the contact lens to refract light; And a drug storage structure that is spaced apart from the center to store the drug, and provides the drug to the eye of a contact lens user.
- a mold for forming a contact lens according to the present embodiment includes: a first mold; And a second mold for curing the liquid porous polymer so that the contact lens has a concave structure with respect to the first mold, and surfaces of the first and second molds in contact with the liquid porous polymer are coated with Teflon.
- a contact lens that can be worn by patients with dry eye syndrome without feeling of foreign body is provided. Further, according to the contact lens according to the present embodiment, a contact lens capable of providing a drug through the user's eye is provided. According to the contact lens mold according to the present embodiment, a mold capable of manufacturing a contact lens more economically is provided.
- FIG. 1 is a plan view of a contact lens according to this embodiment.
- FIG. 2 is a cross-sectional view taken along line A-A' in FIG. 1 and is a view showing an outline of a tear storage structure.
- FIG. 3 is a plan view schematically showing an embodiment of the contact lens according to the first embodiment.
- FIG. 4 is a cross-sectional view taken along line A-A' of FIG. 3.
- FIG. 5 is a cross-sectional view schematically showing another embodiment of the contact lens according to the second embodiment.
- FIG. 6 is a plan view schematically showing another embodiment of the contact lens according to the second embodiment.
- FIG. 7 is a schematic cross-sectional view of a cross-sectional view taken along line A-A' of FIG. 6
- FIG. 8(a) is a diagram showing examples of the drug outlet 148 viewed in the direction B in FIG. 6 in the cross section of the contact lens
- FIG. 8(b) is a view showing another example of the drug outlet 148 .
- FIG. 9 is a plan view schematically showing another embodiment of the contact lens according to the second embodiment.
- 10(a) and 10(b) are views illustrating a mold for manufacturing a contact lens according to the present embodiment.
- FIG. 11 is a photograph in which the contact lens structure according to the present embodiment is enlarged through a 3D digital microscope (HI-ROX, KH-7700) and the size of each structure is measured.
- FIG. 13 is a photograph of a fluid stored inside the tear storage structure as a result of performing a tear storage test using an artificial eye.
- FIG. 14 is a diagram showing a drug release pattern according to the chitosan content.
- 15 is a diagram showing a drug release pattern according to the ratio of HPMC 100000 1% + chitosan 0.2% in this experiment.
- the contact lens according to the present embodiment includes: a vision correction lens unit positioned at the center of the contact lens to refract light to correct vision, and a plurality of radially positioned contact lenses from the center of the contact lens to store tears. It includes a tear storage structure, wherein the tear storage structure includes: a concave structure in which the introduced tear is stored by being formed at a first depth in the contact lens.
- a plurality of tear storage structures 110 may be radially disposed at the center of the contact lens 10.
- the contact lens 10 may include eight tear storage structures 110 as illustrated, but may include a smaller number or a greater number of tear storage structures than this.
- the contact lens 10 may be formed of a microporous polymer material. Therefore, tears stored in the tear storage structure 110 through the pores may be provided to the user's eyeball or may be diffused into the contact lens 10. From this, it is possible to reduce the user's contact lens foreign body feeling by the tears provided to the user's eyeball and the tears spread to the contact lens 10.
- the microporous polymer may be 2-HEMA (2-hydroxyethyl methacrylate, 2-hydroxyethylmethacrylate), glycerol methacrylate, silicone hydrogel, persperylcholine, or the like.
- the microporous polymer is a crosslinking agent (EGDMA, ethylene glycol dimethacrylate) of less than 2%, an initiator (AIBN, 2,2′-azobis (2-methylpropionitrile)), organic A compound (MAA, methacrylic acid) may be appropriately mixed and used.
- EGDMA crosslinking agent
- AIBN 2,2′-azobis (2-methylpropionitrile)
- MAA methacrylic acid
- the contact lens includes a vision correction lens unit 200 positioned on the cornea and refracting light incident to the pupil.
- the vision correction lens unit 200 may have a diopter adjusted by a first mold and/or a second mold, as described later, and may be manufactured with a predetermined diopter to correct nearsightedness, farsightedness, astigmatism, etc. I can.
- the tear storage structure 110 may be disposed radially outwardly from the vision correction lens unit 200.
- FIG. 2 is a cross-sectional view taken along line A-A' in FIG. 1 and is a view showing an outline of the tear storage structure 110.
- the tear storage structure 110 includes a concave structure 112 formed in the contact lens at a first depth d1 to store the introduced tear.
- the tear storage structure 110 may further include a gas discharge structure 114 formed with a second depth d2 to discharge air remaining in the concave structure 112 to the outside of the contact lens 10.
- FIG. 2 a broken line shows a surface where the contact lens 10 and the user's eye contact each other.
- an average of 0.6 ml of tears are secreted into the eye every day to prevent dry eye.
- the secreted tears are stored in the concave structure 112 of the contact lens 10 through the surface in contact with the user's eyeball. Due to the concave structure 112, the contact area between the eyeball and the contact lens 10 may be reduced, and tears stored in the concave structure 112 may be discharged to the user's eyeball or diffuse into the contact lens 10. From this, it is possible to reduce the user's contact lens foreign body feeling.
- the tear storage structure 110 may further include a gas discharge structure 114. Gases such as air may be collected together with tears in the concave structure 112.
- the gas discharge structure 114 is formed to have a second depth d2 having a larger value than the depth d1 at which the concave structure 112 is formed to discharge gas to the outside.
- the contact lens 10 is formed of a porous polymer, and the gas collected in the concave structure 112 has a second depth, and is discharged to the outside through fine holes formed in the porous polymer.
- the tear storage structure 110 for storing tears may store 0.1875 mm3 of tears per one, and the contact lens 10 including the eight tear storage structures 110 as in the embodiment illustrated in FIG. ) Can store about 1.5 mm3 of tears or less. From this configuration, since tears stored in the concave structure 112 are discharged to the cornea, when a patient with dry eye syndrome wears a contact lens, tears are stored and the contact area is reduced, thereby minimizing the phenomenon of evaporation of tears and improving the lubrication of the tear film to improve the user's fit and feel. An advantage is provided that can be minimized.
- the contact lens according to the present embodiment includes a vision correction lens unit located in the center of the contact lens to refract light and a drug storage structure that is spaced apart from the center to store a drug, and provides a drug to the eye of a contact lens user. do.
- FIG. 3 is a plan view schematically showing an embodiment of the contact lens 11 according to the second embodiment
- FIG. 4 is a cross-sectional view taken along line A-A' in FIG. 3.
- the contact lens 11 includes a drug storage structure 120.
- the drug storage structure 120 includes a drug chamber 122 formed in a concave structure in the contact lens 11 to store the drug D in the concave structure, and a cover member 124 covering at least the drug chamber 122
- the cover member 124 is a microporous polymer material in which micropores are formed, and the drug D is provided to the eyeball through micropores.
- the drug chamber 122 may be formed in a concave structure inside the contact lens 11.
- a plurality of drug chambers 122 may be formed on a single contact lens 11, and the plurality of drug chambers 122 may store a plurality of different drugs. In another embodiment, the plurality of drug chambers 122 may store the same drug.
- the drug chamber 122 may be formed to have a predetermined volume.
- the drug chamber 122 may be formed to store a drug in a volume of 1 ⁇ l to 2 ⁇ l.
- the drug chamber 122 may be formed in a volume corresponding to a single dose of the stored drug.
- the drug chamber 122 may be filled with a drug at a predetermined rate (for example, 50%), and tears may be introduced into the remaining space for storage. Therefore, drug release may be smoothly performed depending on the amount of the introduced tears.
- the cover member 124 covers the drug chamber 122.
- the cover member 124 may cover the rear surface of the contact lens 11 as illustrated in FIG. 3.
- the cover member 124 may cover only the drug chamber 122 so that the stored drug D does not leak.
- the cover member 124 may be formed of a microporous polymer material in which micropores are formed, and the drug stored in the drug chamber 122 is provided to the eye of the user through the micropores of the cover member 124.
- the rate and pattern at which the drug is released can be adjusted according to the combination, type, and content of the polymer forming the cover member 124.
- the cover member 124 may be, for example, a water-soluble polymer or a water-insoluble (permeable) polymer.
- a water-soluble polymer or a water-insoluble (permeable) polymer.
- the water-insoluble polymer does not dissolve in tears, there is an advantage in that no foreign body sensation occurs in the eyes.
- the water-soluble polymer capable of forming the cover member 124 is acacia, agar, alginic acid, carbomer, carrageenan, cellulose acetate, ceratonia, chitosan, chondroitin sulfate, dermatan sulfate, dextran, ethylcellulose, Gelatin, guar gum, hydroxyethylcellulose, hydropropylbetadex, hydroxypropylcellulose, hypromellose, hypromellose acetate succinate, hypromellose phthalate, karaya gum, locust bean gum, methylcellulose, molasses, pectin, poly Acrylamide, polycaprolactone, polyethylene oxide, polyethylene glycol, polyhydroxyethyl methacrylate, polyorthoester, polyvinyl alcohol, polyvinylpyrrolidone, sodium alginate, carboxymethylcellulose, sodium hyaluronate, tragacanth, tri
- the water-insoluble polymer that can form the cover member 124 is acetyl alcohol, acetyl ester wax, acetyl tributyl citrate, aluminum monostearate, carnaubanap, cellulose acetate, cellulose acetate phthalate.
- the drug (D) that can be stored in the drug chamber 122 of the contact lens 11 according to the present embodiment is, for example, a treatment for dry eye syndrome, a treatment for glaucoma, a drug for reducing intraocular pressure, a treatment for vision damage, an antibacterial agent, a treatment for allergic conjunctivitis, It may be any one or more of a therapeutic agent for eyelid conjunctivitis, a therapeutic agent for night blindness, a therapeutic agent for vision loss, a therapeutic agent for eye inflammation, a therapeutic agent for cataracts, an antiviral agent, an antiviral agent, an acidophilic agent, a deoxidation enzyme inhibitor, and a macular degeneration agent.
- the scope of the present invention is not limited thereto.
- the treatment for dry eye syndrome is hyaluronic acid, carboxymethylcellulose, potassium chloride, sodium chloride, hydroxypropylmethylcellulose, chondroitin, glucose, polyvinylpyrrolidone, carbomer, lanolin, dextran, trehalose, sorbic acid, hydride Roxyethylcellulose, taurine, polysorbate 80, polyvinyl alcohol, benzalkonium chloride, propylene glycol, macrogol, guar gum, glycerol, cetrimide, glycine, asparagine, retinol palmitate, vitamin E, edetic acid, hydride It may contain any one or more of oxymethylcellulose, phosphoric acid, cyclosporine, diquafosol, povidone, and Lipitegrast. However, the scope of the present invention is not limited thereto.
- any one or more of a glaucoma therapeutic agent and an intraocular pressure-lowering agent may be thymorol, dorzolamide, latanoprost, brimonidine, tafluprost, brinzolamide, travoprost, bimatoprost, betaxorol, Carteolol, carbacol, nipradirol, apraclonidine, pilocarpine, levobunolol, isopropyl unoprostone, acetylcholine, benzalkonium chloride, befunolol, acetazolamide, metazolamide, diclofenamide and It may contain any one or more of unoprostone. However, the scope of the present invention is not limited thereto.
- the treatment for vision impairment may include any one or more of ranibizumab, aflibercept, and verteporfin.
- the scope of the present invention is not limited thereto.
- the antibacterial agent is levofloxacin, ofloxacin, tobramycin, moxifloxacin, gatifloxacin, oxytetracycline, polymyxin B, sulfamethoxazole, taurine, glycyrrhizinic acid, tosufloxacin, aminocapronic acid , Lomefloxacin, Chloramphenicol, Dexamethasone, Tetrahydrozoline, Chlorpheniramine, Natamycin, Ciprofloxacin, Enoxolone, Fusidic Acid, Guiaazulene, Azulene, Erythromycin, Colistin, Gentamicin, Benzalkonium Chloride, Sulfamethy It may contain any one or more of sol, cefmenoxime, norfloxacin, micronomicin, and tetracycline. However, the scope of the present invention is not limited thereto.
- any one or more of allergic conjunctivitis treatment and blepharoconjunctivitis treatment is olopatadine, ketotifen, alcaptadine, bepotastine, azelastine, chlorpheniramine, neostigmine, pyridoxine, tetrahydrozoline , Epinastine, Napazoline, Controitin, Panthenol, Glycyrrhizic acid, Aminocaproic acid, Retinol, Vitamin E, Pheniramine, Allantoin, Chlorobutanol, Taurine, Aspartic acid, Cyanocobalamin, Enoxolone, Benzalkonium chloride , Azulene, acitazanolast, cromoline, tranilast, femirolast, N-acetylaspanyl, rhodoxamide and N-acetylaspartylglutamic acid.
- the scope of the present invention is not limited thereto.
- the therapeutic agent for ophthalmic inflammation is fluorometholone, dexamethasone, tetrizoline, prednisolone, rodeprednol, rimexolone, triamcinolone, hypromellose, napazoline, chlorphenamine, bromfenac, ketorolac, benda Zak, diclofenac, pranoprofen, flubiprofen, tobramycin, neomycin, polymyxin B, gentamicin, prourometholone, chloramphenicol, and may include any one or more of sulfamethoxazole.
- the scope of the present invention is not limited thereto.
- the cataract therapeutic agent may include any one or more of potassium iodide, sodium iodide, pyrenoxine, thiamine, azipentacene, bendazac lysine, prednisolone, nepafenac and diclofenac.
- potassium iodide sodium iodide
- pyrenoxine pyrenoxine
- thiamine azipentacene
- bendazac lysine bendazac lysine
- prednisolone nepafenac and diclofenac.
- the scope of the present invention is not limited thereto.
- the antiviral agent may include any one or more of acyclovir, ganciclovir, and trifluridine.
- acyclovir ganciclovir
- trifluridine the scope of the present invention is not limited thereto.
- the sandongjak may contain any one or more of tropicamide, phenylephrine, aminocaproic acid, atropine, cyclopentolate, and homatropine.
- the scope of the present invention is not limited thereto.
- the deoxidation dehydratase inhibitor may include any one or more of acetazolamide, metazolamide, dorzolamide, and brinzolamide.
- the scope of the present invention is not limited thereto.
- the therapeutic agent for macular degeneration may include any one or more of ranibizumab, bevacizumab, and valtipolpine.
- ranibizumab ranibizumab
- bevacizumab bevacizumab
- valtipolpine valtipolpine
- the contact lens 11 may include a plurality of drug chambers 122, and each drug chamber 122 may include a plurality of different drugs (D) described above. I can. In another embodiment, the plurality of drug chambers 122 may contain the same drug (D).
- a composition in which a drug to be administered and a polymer for controlling the release of the drug are mixed is applied to the lens surface or filled in a drug storage structure.
- the polymer is provided to the user's eyes together with the drug, causing a foreign body sensation in the eyes.
- the drug is provided to the user's eye through the cover member, the advantage of removing the foreign body sensation that the prior art gives to the user is provided.
- the contact lens according to the present embodiment includes a drug storage structure 130.
- the drug storage structure 130 is formed in a concave structure in the contact lens to store a drug in the concave structure, and at least in the cover member 134 and the cover member 134 covering the drug chamber 132 It contains an excretory structure that provides the drug to the eye.
- the discharge structure includes one or more holes H1 and H2. Cross-sectional areas of the one or more holes H1 and H2 may be different from each other or may be the same as each other.
- the discharge structure comprises one hole.
- the cross-sectional area of the hole H1 and the hole H2 on the side of the drug storage chamber 132 and the cross-sectional area of the side hole close to the user's eye are the same.
- the cross-sectional area of the drug storage chamber 132 side of one hole and the cross-sectional area of the side hole close to the user's eye may be different from each other.
- the cross-sectional area of a single hole or holes may have a cross-sectional area through which the drug stored in the drug chamber 132 can be discharged by a capillary phenomenon, through which drugs easily stored in the drug chamber 132 Can be provided to the user's eye. Furthermore, by adjusting the cross-sectional area of the hole, the dose per hour of the drug stored in the drug chamber 132 can be adjusted.
- the cover member 134 may be made of a silicon material.
- the cover member 134 may be formed of a microporous polymer material to provide drugs to a user through the cover member 134 as well as holes included in the discharge structure.
- the cover member 134 may be formed of the same polymer material as the lens, the water-soluble polymer material, and the water-insoluble polymer material.
- the contact lens 13 includes a drug storage structure 140.
- the drug storage structure 140 has a drug chamber 142 formed in a concave structure to store a drug in the concave structure, and a drug discharge path 146 formed in a concave structure in the contact lens and connected to the drug chamber 142 to release the drug. ), and a cover member 144 covering the drug discharge path 146 and the drug chamber 142, and the cover member 144 opens an end of the drug discharge path to form a drug discharge port 148.
- the drug discharge path 146 is connected to the drug chamber 142 to guide the drug D contained in the drug chamber 142 to the drug discharge port 148.
- 7 shows an example in which the drug discharge path 146 and the drug chamber 142 are formed to have the same height, but in an example not shown, the drug discharge path 146 has a height smaller than the height of the drug chamber 142 Can be formed.
- the cover member 144 may be formed to cover the rear surface of the contact lens 13 as illustrated in FIG. 6, and may form a drug discharge port 148 by opening the lower end of the drug discharge passage 146.
- FIG. 8(a) is a view showing an example of the drug outlet 148 as viewed in the direction B in FIG. 6 of the cross section of the contact lens
- FIG. 8(b) is a view showing another example of the drug outlet 148 . 6 to 8(a)
- the cover member 144 exposes the lower end of the drug discharge path 146 to form a drug discharge port 148. Accordingly, according to the example illustrated in FIG. 8A, the drug outlet 148 discharges the drug D to the lower surface of the contact lens 13.
- the cover member 144 may be formed to cover all the lower surfaces of the drug discharge passage 146, but the side end of the drug discharge passage 146 Since it is open, the drug discharge port 148 may be formed at the end of the drug discharge path 146 as illustrated in FIG. 8(b).
- the user of the exemplified contact lens 13 may unconsciously blink the eyelid, and the drug D stored in the drug chamber 142 by the pressure provided while moving the upper part of the contact lens 13 is the drug outlet ( 148) and provided to the user's eye.
- the contact lens 14 includes a drug storage structure 150.
- the drug storage structure 150 has a drug chamber 152 formed in a concave structure to store a drug in the concave structure, and a drug discharge path 156 connected to the drug chamber 152 to release the drug by being formed in a concave structure in the contact lens.
- a cover member 154 covering the drug discharge path 156 and the drug chamber 152, and the cover member 154 opens an end of the drug discharge path to form a drug discharge port 158.
- the drug chamber 152 may be formed in a circular shape along the center of the contact lens 14. Thus, it is possible to store a single drug in a large amount.
- the drug discharge port 158 is formed on the lower surface of the contact lens 14 as in the examples described above to discharge the drug D, and the drug discharge port 158 is a drug discharge path ( It is formed on the side of the contact lens 156 so that the drug can be discharged to the end of the contact lens 14.
- FIGS. 10(a) and 10(b) are views illustrating a mold for manufacturing a contact lens according to the present embodiment.
- Fig. 10(a) is a cross-sectional view schematically showing the first formwork 10a
- Fig. 10(b) is a view schematically showing the second formwork 10b.
- the mold according to the present embodiment includes a first mold 10a and a second mold 10b.
- a polymer is placed on the first mold 10a, the second mold 10b is placed, and the polymer is cured to form a contact lens having a desired shape.
- the process of curing the polymer may be performed by providing heat.
- a structure 100 ′ forming a concave structure in a contact lens and a structure 114 ′ forming a gas discharge structure in the second mold 10b And a structure 200' for forming a vision correction lens unit so that the contact lens has a desired diopter.
- the structure 100' and the structure 200' may be formed on the first mold.
- a structure for forming a concave structure may be formed in the second mold 10, and a structure for forming a gas discharge structure may not be formed.
- Teflon gas is applied to the surface in contact with the polymer forming the contact lens as shown in Figs. 10(a) and 10(b).
- Perform the used plasma treatment The surface of the mold is hydrophobically modified through plasma treatment, and the contact lens formed by curing the polymer is easily separated by coating with Teflon having a thickness of several thousand ⁇ by plasma polymerization of C4F8. Accordingly, since the disposable mold according to the prior art can be replaced and used semi-permanently, the effect of reducing the mass production cost of the lens can be expected.
- the mold mold is made of 304-grade stainless steel, and the three-dimensional shape is processed using a milling machine (CNC machine 850), and the surface is polished after processing to increase the light transmittance.
- the radius of curvature of the mold 10b and the outer mold 10a for storing tears or drugs in contact with the eyeball is 8.8 mm and 8.6 mm, respectively.
- the implemented contact lens is a crosslinking agent (EGDMA, ethylene glycol dimethacrylate) and initiator (AIBN, 2,2′-azobis (2-methylpropionitrile)) to increase the stability of 2% in 98% 2-HEMA (2-hydroxyethylmethacrylate). And it was prepared by mixing organic compounds (MAA, methacrylic acid) to increase the moisture content of the lens.
- EGDMA crosslinking agent
- AIBN 2,2′-azobis (2-methylpropionitrile
- FIG. 11 is a photograph in which the contact lens structure according to the present embodiment is enlarged through a 3D digital microscope (HI-ROX, KH-7700) and the size of each structure is measured.
- the tear storage structure 110 can confirm that the gas discharge structure 114 is successfully formed, and the total volume is 1.4 mm 3.
- FIG. 12 is a photograph of mounting the manufactured lens in the pupil of an artificial eye in order to test the tear storage effect of the manufactured lens.
- 13 is a photograph of a fluid stored inside the tear storage structure as a result of performing a tear storage test using an artificial eye.
- An external syringe pump KD scientific, KDS-100 was used to secrete fluid through the tear tube into the artificial eye.
- a fluid mixed with water and blue ink was selected as a virtual tear. After the mixed fluid was injected for 20 seconds at a flow rate of 0.6 ml per minute, water was injected again to confirm the presence or absence of tears in the tear storage structure to remove ink outside the tear storage structure. All processes were observed with a 3D digital microscope (HIROX, KH-7700). As a result of the test, it was confirmed that the fluid was stored inside the proposed lens structure.
- cyclosporine (cyclosporine, Sigma-Aldrich, Kunststoff, Germany) was used as a drug.
- the drug was prepared by weighing 160 mg of cyclosporine in 6 ml of 80% (v/v) ethanol.
- the cover member was formed of a microporous polymer.
- the porous polymer was prepared by adjusting the content of HPMC 100000 (hydroxypropyl methylcellulose 2208, 90SH-105, Shin-Etsu Chemical Co., Ltd., Tokyo, Japan) and chitosan in 10 mL of purified water, and PEG 300 (BASF Ludwigshafen, as a plasticizer). Germany) was added to 2% (w/v).
- HPMC 100000 hydroxypropyl methylcellulose 2208, 90SH-105, Shin-Etsu Chemical Co., Ltd., Tokyo, Japan
- PEG 300 BASF Ludwigshafen, as a plasticizer
- a total of 25 ⁇ l of the prepared drug was injected into the drug storage structure of the contact lens using a syringe and dried at 45° C. for 1 hour, and 35 ⁇ l of a microporous polymer was applied thereon and dried at 45° C. for 1 hour.
- the drug release test was performed as follows.
- the contact lens was fixed between the glass plate and the Franz Diffusion Cell.
- a transdermal absorption system (Franz Diffusion Cell System, Logan Instruments Corp. of VTC 300, NJ, USA) was stirred at 35°C using a stirrer.
- Sample collection time was set to 0.5, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5, 7.5, 8.5 and 9.5 hours when 0.05 M pH 7.4 phosphate buffer was used as the buffer.
- the collected sample solution was filtered using a 0.45 ⁇ m membrane filter, and this was used as a sample for quantitative analysis.
- Table 1 is a table showing the material content of the drug (D) and the cover member (P).
- D 25 ⁇ l of drug layer (cyclosporine 16 mg/ml) dispensed.
- P polymer layer (chitosan + PEG 2% (w/v)) 30 ⁇ l aliquot
- a diagram illustrated by a red circle is a D+P (Chitosan-0.5% (w/v) diagram illustrated by an upward triangle and a D+P (Chitosan-1.0% (w/v) diagram illustrated by a downward triangle). ) And overlapped.
- the cumulative drug release in the absence of a cover member was nonlinear curve-fitting with a first-order exponential function, and the release rate was analyzed as a time constant ( ⁇ ). The time to reach 63% of the maximum drug accumulation (time constant) was measured as 2.54 hours.
- time constant time constant
- chitosan was used as the material of the cover member
- the cumulative drug release was linear curve-fitting as a linear function, and the release characteristics were evaluated using the slope ( ⁇ ).
- Table 2 is a table showing the material content of the drug (D) and the cover member (P).
- FIG. 15 is a diagram showing a drug release pattern according to the ratio of HPMC 100000 1% + chitosan 0.2% in this experiment.
- D 25 ⁇ l of drug layer (cyclosporine 16 mg/ml) dispensed.
- P high molecular weight (HPMC 100000 1% (w/v)): C (chitosan 0.2% (w/v)) + PEG 2% (w/v)) 30 ⁇ l aliquot.
- H: C) H(HPMC 100000 1%(w/v)): C(chitosan 0.2%(w/v)) ratio
- drug release can be controlled by filling a contact lens with a drug and using a cover member made of a microporous polymer material.
Abstract
Description
Claims (20)
- 콘택트렌즈로서, 상기 콘택트렌즈는:상기 콘택트렌즈의 중심부에 위치하여 빛을 굴절하는 시력 교정 렌즈부; 및상기 콘택트렌즈의 중심으로부터 복수개가 방사상으로 위치하여 눈물을 저장하는 눈물 저장 구조를 포함하며, 상기 눈물 저장 구조는:상기 콘택트렌즈에 제1 깊이로 형성되어 유입된 눈물이 저장되는 오목 구조를 포함하는 콘택트렌즈.
- 제1항에 있어서,상기 콘택트렌즈는,미세 다공을 가지는 미세 다공성 고분자 재질인 콘택트렌즈.
- 제1항에 있어서,상기 눈물 저장 구조는,상기 오목 구조에 잔존하는 공기를 상기 콘택트렌즈 외부로 배출하도록 상기 제1 깊이보다 더 큰 제2 깊이로 형성된 기체 배출 구조를 더 포함하는 콘택트렌즈.
- 제1항에 있어서,상기 눈물 저장 구조는,상기 콘택트렌즈의 중심으로부터 8개가 방사상으로 배치된 콘택트렌즈.
- 제1항에 있어서,상기 눈물 저장 구조는,총 1.5 ㎣ 이하의 눈물을 저장하는 콘택트렌즈.
- 콘택트렌즈로서, 상기 콘택트렌즈는:상기 콘택트렌즈의 중심부에 위치하여 빛을 굴절하는 시력 교정 렌즈부; 및상기 중심부로부터 이격되어 위치하여 약물을 저장하는 약물 저장 구조를 포함하며,상기 콘택트렌즈 사용자의 안구에 상기 약물을 제공하는 콘택트렌즈.
- 제6항에 있어서,상기 콘택트렌즈는,미세 다공을 가지는 미세 다공성 고분자 재질인 콘택트렌즈.
- 제6항에 있어서,상기 약물 저장 구조는,상기 콘택트렌즈에 오목 구조(concave structure)로 형성되어 상기 오목 구조에 약물을 저장하는 약물 체임버;적어도 상기 약물 체임버를 덮는 커버 부재를 포함하며,상기 커버 부재는 미세 다공들이 형성된 미세 다공성 고분자 재질로,상기 약물은 상기 미세 다공들을 통하여 상기 안구에 제공되는 콘택트렌즈.
- 제6항에 있어서,상기 약물 저장 구조는,상기 콘택트렌즈에 오목 구조(concave structure)로 형성되어 상기 오목 구조에 약물을 저장하는 약물 체임버와,적어도 상기 약물 체임버를 덮는 커버 부재 및상기 커버 부재에 형성되어 상기 약물을 상기 안구에 제공하는 배출 구조를 포함하는 콘택트렌즈.
- 제9항에 있어서,상기 배출 구조는,하나 또는 하나 이상의 홀을 포함하며,상기 하나 이상의 홀의 면적은 서로 같거나, 서로 다른 콘택트렌즈.
- 제6항에 있어서,상기 약물 저장 구조는,상기 콘택트렌즈에 오목 구조(concave structure)로 형성되어 상기 오목 구조에 약물을 저장하는 약물 체임버와,상기 콘택트렌즈에 오목 구조로 형성되어 상기 약물을 방출하도록 상기 약물 체임버와 연결된 약물 배출로 및상기 약물 배출로와 상기 약물 체임버를 덮는 커버 부재를 포함하며,상기 커버 부재는 상기 약물 배출로 단부를 개방하여 약물 배출구를 형성하는 콘택트렌즈.
- 제11항에 있어서,상기 약물 저장 구조는서로 이격되어 연결되지 않은 복수의 약물 체임버와,상기 복수의 약물 체임버와 각각 연결된 복수의 약물 배출로를 포함하며,상기 복수의 약물 체임버에는 동일하거나 서로 다른 약물이 저장된 콘택트렌즈.
- 제11항에 있어서,상기 약물 저장 구조는상기 콘택트렌즈에 형성된 원형의 단일한 약물 체임버와,상기 단일한 체임버와 연결된 복수의 약물 배출로를 포함하며,상기 복수의 약물 배출로는 상기 콘택트렌즈의 단부로 상기 약물을 배출하는 콘택트렌즈.
- 제6항에 있어서,상기 약물은,안구건조증 치료제, 녹내장 치료제, 안압강하제, 시력 손상 치료제, 항균제, 알러지성 결막염 치료제, 안검결막염 치료제, 야맹증 치료제, 시력감퇴 치료제, 안염증 치료제, 백내장 치료제, 항바이러스제, 산동약, 탈산탈수효소 억제제 및 황반변성 치료제 중 어느 하나 이상을 포함하는 콘택트렌즈.
- 제8항에 있어서,상기 미세 다공성 고분자는,수용성 고분자 및 비수용성 고분자 중 어느 하나인 콘택트렌즈.
- 제15항에 있어서,상기 수용성 고분자는아카시아, 한천, 알긴산, 카보머, 카라기난, 셀룰로오스 아세테이트, 세라토니아, 키토산, 콘드로이틴 황산염, 데르마탄 황산, 덱스트란, 에틸셀룰로오스, 젤라틴, 구아검, 하이드록시에틸셀룰로오스, 하이드로프로필베타덱스, 하이드록시프로필셀룰로오스, 히프로멜로스, 히프로멜로스 아세테이트 석시네이트, 히프로멜로스 프탈레이트, 카라야검, 로커스트 콩검, 메틸셀룰로오스, 당밀, 펙틴, 폴리아크릴아마이드, 폴리카프로락톤, 폴리에틸렌 옥사이드, 폴리에틸렌글리콜, 폴리히드록시에틸메타크릴레이트, 폴리오르토에스테르, 폴리비닐알코올, 폴리비닐피로리돈, 알긴산 나트륨, 카복시메틸셀룰로오스, 히알루론산 나트륨, 트라가칸트 및 트리에틸 시트레이트, 잔탄검 중 어느 하나 이상을 포함하는 콘택트렌즈.
- 제15항에 있어서,상기 비수용성 고분자는아세틸 알코올, 아세틸 에스터 왁스, 아세틸트리부틸 시트레이트, 알루미늄모노스테아레이트, 카르나우바납, 셀룰로스 아세테이트, 셀룰로우스 아세테이트 프탈레이트, 다이뷰틸 세바케이트, 에틸셀룰로오스, 글리세린 모노스테아레이트, 글리세릴 베헤네이트, 글리세릴 모노올레이트, 글리세릴 팔미토스테아레이트, 수소첨가 피마자 기름, 수소첨가 식물성 유지 타입 1, 아이소프로필 팔미테이트, 폴리카프로락톤, 폴리글리콜라이드, 폴리젖산, 폴리락타이드, 폴리메타크릴레이트, 폴리옥시글리세라이드, 셸락, 스테아르산, 스테아릴 알코올, 트리뷰틸 시트레이트, 백랍, 황랍 및 제인 중 어느 하나 이상을 포함하는 콘택트렌즈.
- 콘택트렌즈를 형성하기 위한 몰드로, 상기 몰드는:제1 형틀;상기 제1 형틀에 대하여 상기 콘택트렌즈가 오목 구조를 가지도록 액체 다공성 고분자를 경화(cure)하는 제2 형틀을 포함하며,상기 제1 형틀과 상기 제2 형틀에서 상기 액체 다공성 고분자와 접촉하는 면은 테플론으로 코팅된 몰드.
- 제18항에 있어서,상기 몰드는 스테인레스 스틸로 이루어진 몰드.
- 제18항에 있어서,상기 몰드는 C4F8 플라즈마 중합 처리를 통하여 소수성 표면 처리된 몰드.
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JP2022504289A JP2022544020A (ja) | 2019-07-24 | 2020-07-10 | コンタクトレンズ、及びそれを製造するためのモールド |
EP20843161.9A EP4006625A4 (en) | 2019-07-24 | 2020-07-10 | CONTACT LENS AND MOLD FOR MAKING THEREOF |
CN202080053418.2A CN114245877A (zh) | 2019-07-24 | 2020-07-10 | 一种隐形眼镜及用于制备其的模具 |
CA3148416A CA3148416A1 (en) | 2019-07-24 | 2020-07-10 | Contact lens and mold for manufacturing same |
MX2022000908A MX2022000908A (es) | 2019-07-24 | 2020-07-10 | Lente de contacto y molde para la fabricación de esta. |
BR112022001243A BR112022001243A2 (pt) | 2019-07-24 | 2020-07-10 | Lente de contato |
US17/629,406 US20220314562A1 (en) | 2019-07-24 | 2020-07-10 | Contact lens and mold for manufacturing same |
AU2020316211A AU2020316211A1 (en) | 2019-07-24 | 2020-07-10 | Contact lens and mold for manufacturing same |
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2020
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- 2020-07-10 WO PCT/KR2020/009084 patent/WO2021015465A1/ko unknown
- 2020-07-10 AU AU2020316211A patent/AU2020316211A1/en active Pending
- 2020-07-10 CA CA3148416A patent/CA3148416A1/en active Pending
- 2020-07-10 KR KR1020200085709A patent/KR102477686B1/ko active IP Right Grant
- 2020-07-10 US US17/629,406 patent/US20220314562A1/en active Pending
- 2020-07-10 EP EP20843161.9A patent/EP4006625A4/en active Pending
- 2020-07-10 BR BR112022001243A patent/BR112022001243A2/pt unknown
- 2020-07-10 JP JP2022504289A patent/JP2022544020A/ja active Pending
- 2020-07-10 CN CN202080053418.2A patent/CN114245877A/zh active Pending
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2022
- 2022-08-30 KR KR1020220109489A patent/KR20220127186A/ko not_active Application Discontinuation
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US20090004245A1 (en) * | 2007-06-28 | 2009-01-01 | Orilla Werhner C | Use of an iris simulated layer to allow aesthetic appearance drug loaded contact lens |
KR101877312B1 (ko) * | 2016-11-22 | 2018-07-12 | 한국과학기술연구원 | 눈물 채취 또는 약물 전달을 위한 콘텍트 렌즈 및 그 제조 방법 |
WO2018204395A1 (en) * | 2017-05-01 | 2018-11-08 | Pres-By Vision Ltd. | Dynamic tear lenses |
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Also Published As
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KR102477686B1 (ko) | 2022-12-15 |
BR112022001243A2 (pt) | 2022-04-05 |
KR20210012913A (ko) | 2021-02-03 |
AU2020316211A1 (en) | 2022-02-17 |
CN114245877A (zh) | 2022-03-25 |
JP2022544020A (ja) | 2022-10-17 |
CA3148416A1 (en) | 2021-01-28 |
MX2022000908A (es) | 2022-05-10 |
US20220314562A1 (en) | 2022-10-06 |
EP4006625A1 (en) | 2022-06-01 |
EP4006625A4 (en) | 2023-09-06 |
KR20220127186A (ko) | 2022-09-19 |
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