WO2021000440A1 - Dispositif de collecte d'humeur aqueuse et procédé de collecte d'humeur aqueuse - Google Patents

Dispositif de collecte d'humeur aqueuse et procédé de collecte d'humeur aqueuse Download PDF

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Publication number
WO2021000440A1
WO2021000440A1 PCT/CN2019/110062 CN2019110062W WO2021000440A1 WO 2021000440 A1 WO2021000440 A1 WO 2021000440A1 CN 2019110062 W CN2019110062 W CN 2019110062W WO 2021000440 A1 WO2021000440 A1 WO 2021000440A1
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WO
WIPO (PCT)
Prior art keywords
aqueous humor
puncture needle
tube
outer cylinder
liquid
Prior art date
Application number
PCT/CN2019/110062
Other languages
English (en)
Chinese (zh)
Inventor
赵潺
夏超然
孙月广
Original Assignee
北京华视诺维医疗科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201910590699.4A external-priority patent/CN110236782B/zh
Priority claimed from CN201921024358.2U external-priority patent/CN210872425U/zh
Priority claimed from CN201910591368.2A external-priority patent/CN110236783B/zh
Priority claimed from PCT/CN2019/094384 external-priority patent/WO2021000256A1/fr
Priority claimed from PCT/CN2019/094383 external-priority patent/WO2021000255A1/fr
Priority claimed from CN201910591476.XA external-priority patent/CN110236784B/zh
Priority claimed from CN201921024325.8U external-priority patent/CN210872424U/zh
Priority claimed from CN201921028861.5U external-priority patent/CN210872426U/zh
Application filed by 北京华视诺维医疗科技有限公司 filed Critical 北京华视诺维医疗科技有限公司
Priority to US17/624,393 priority Critical patent/US20220354468A1/en
Priority to PCT/CN2020/096860 priority patent/WO2021000743A1/fr
Priority to JP2021577950A priority patent/JP7337967B2/ja
Priority to EP20834808.6A priority patent/EP3995215A4/fr
Publication of WO2021000440A1 publication Critical patent/WO2021000440A1/fr
Priority to IL289549A priority patent/IL289549A/en
Priority to JP2023134836A priority patent/JP2023164441A/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery

Definitions

  • the invention relates to the technical field of medical appliances.
  • Anterior chamber puncture of the eye is a medical technology that pierces the cornea of the eye to make the aqueous humor flow out. It has important application value in ophthalmology clinical research work. It is mainly used to reduce intraocular pressure, aqueous humor collection and other therapeutic pretreatments. Room discharge.
  • the present invention provides an aqueous humor collection device and aqueous humor collection method, which can control the drainage speed of aqueous humor during the puncture process, and can prevent the aqueous humor from being polluted after collection. Waste due to transfer, thereby improving safety and reliability.
  • the first aspect of the present invention provides an aqueous humor collection device, the aqueous humor collection device comprising:
  • the outer cylinder is provided with a puncture needle installation end and a liquid sampling tube installation end at both axial ends;
  • the puncture needle is fixedly installed at the puncture needle installation end and is provided with an inner end of the puncture needle located in the barrel cavity of the outer cylinder and an outer end of the puncture needle located outside the barrel cavity of the outer cylinder;
  • the liquid sampling tube assembly includes a liquid sampling tube that is inserted into the outer cylinder cavity from the installation end of the liquid sampling tube and can be inserted and removed in an axial direction, and is arranged in the outer cylinder cavity for The pipe plug for sealing the nozzle of the liquid sampling pipe;
  • the static friction coefficient between the pipe plug and the inner peripheral wall of the outer cylinder is ⁇ 1
  • the static friction coefficient between the pipe plug and the nozzle of the liquid collection tube is ⁇ 2, and satisfies: ⁇ 1 ⁇ 2;
  • the pipe plug is arranged at intervals on the inner peripheral wall of the outer cylinder.
  • smooth contact is formed between the pipe plug and the inner peripheral wall of the outer cylinder.
  • the aqueous humor collection device further includes an anti-sloshing structure for limiting the displacement of the liquid sampling tube assembly along the radial direction of the outer cylinder cavity.
  • the anti-sloshing structure includes an annular groove formed on the outer peripheral wall of the liquid sampling tube assembly and an annular stopper arranged around the annular groove. The radial direction of the annular stopper The outer end abuts against the inner peripheral wall of the outer cylinder.
  • the groove side wall of the annular groove is formed with a groove vent hole penetrating along the axial direction of the outer cylinder cavity, and the outer cylinder cavity is between the pipe plug and the piercing hole.
  • the barrel cavity area between the needle mounting ends communicates with the groove vent.
  • the liquid sampling tube assembly includes a supporting tube frame, the liquid sampling tube is inserted into the inner cavity of the supporting tube frame, and the annular groove is provided on the outer peripheral wall of the supporting tube frame. on.
  • the liquid sampling tube assembly further includes a supporting tube rack, the liquid sampling tube is inserted into the inner cavity of the tube rack of the supporting tube rack, and the anti-sloshing structure includes an outer circumference of the supporting tube rack.
  • a wall or a limiting protrusion protruding from the inner peripheral wall of the outer cylinder, and the radial ends of the limiting protrusion are respectively connected to the outer peripheral wall of the support tube frame and the inner peripheral wall of the outer cylinder.
  • the aqueous humor collection device further includes a needle holder for fixing the puncture needle, and a quick plug connection is formed between the inner end of the needle holder and the puncture needle installation end.
  • the aqueous humor collection device further includes an anti-puncture spacer for isolating the inner end of the puncture needle from the tube plug along the axial direction of the outer cylinder cavity, the anti-puncture spacer It is a detachable piece.
  • the peripheral wall of the outer cylinder is provided with a spacer insertion groove, and the outer cylinder cavity is connected to the spacer insertion groove in the region of the cylinder cavity between the inner end of the puncture needle and the pipe plug.
  • a slot, the anti-puncture spacer is inserted into the barrel cavity area through the spacer insertion slot.
  • the second aspect of the present invention provides a method for collecting aqueous humor from the cornea, including:
  • the liquid collection tube includes:
  • the third aspect of the present invention provides a method for collecting aqueous humor from the eyes of a subject, including:
  • the rear end of the liquid sampling tube assembly is pushed so that the liquid sampling tube in the liquid sampling tube assembly moves toward the inner end of the puncture needle, so that the inner end of the puncture needle passes through the tube Plugging into the collection tube includes:
  • it further includes selecting a negative pressure inside the liquid collection tube, the negative pressure being lower than the intraocular pressure of the subject's eye.
  • the liquid sampling tube assembly is provided with a tube plug so that the liquid sampling tube lumen is in a negative pressure state.
  • the inner end of the puncture needle pierces the tube plug to drain aqueous humor to the liquid sampling tube lumen
  • the amount of fluid in the lumen gradually increases, and the difference between the pressure in the lumen and the pressure in the anterior chamber gradually decreases, so the drainage speed of the aqueous humor is gradually reduced, thereby avoiding the dangerous situation of sudden drop in intraocular pressure and greatly improving safety.
  • the static friction coefficient ⁇ 1 between the pipe plug and the inner peripheral wall of the outer cylinder is smaller than the static friction coefficient between the pipe plug and the nozzle of the liquid sampling tube, which is ⁇ 2, or the pipe plug is arranged at intervals on the inner peripheral wall of the outer cylinder, Ensure that when the liquid sampling tube assembly is pulled out from the outer barrel cavity, the pipe plug always tightly blocks the liquid sampling tube nozzle, avoiding the contact of the aqueous humor in the lumen with the external environment, and ensuring the quality of the collected aqueous humor. Purity, and can avoid the waste caused by the transfer of aqueous humor, thereby improving the reliability of subsequent detection.
  • Figure 1 is a perspective view of an aqueous humor collection device in an embodiment of the present invention
  • Figure 2 is a front view of the aqueous humor collection device in an embodiment of the present invention.
  • FIG. 3 is a main cross-sectional view of the aqueous humor collection device in an embodiment of the present invention when the puncture needle does not pierce the tube plug;
  • FIG. 4 is a main cross-sectional view of the aqueous humor collection device in an embodiment of the present invention when a puncture-proof partition is provided;
  • Figure 5 is a cross-sectional view of the aqueous humor collection device in an embodiment of the present invention.
  • FIG. 6 is a schematic structural diagram of the puncture needle of the aqueous humor collection device according to an embodiment of the present invention when a peripheral wall water outlet hole is provided;
  • FIG. 7 is a schematic structural view of the pipe plug of the aqueous humor collection device in an embodiment of the present invention when the pipe plug has an open peripheral wall and a semicircular pipe plug exhaust channel;
  • FIG. 8 is a schematic structural view of the pipe plug of the aqueous humor collection device according to an embodiment of the present invention when the pipe plug has an open peripheral wall and a semi-rectangular pipe plug exhaust channel;
  • FIG. 9 is a schematic structural diagram of the pipe plug of the aqueous humor collection device according to an embodiment of the present invention when a peripheral wall closed and circular pipe plug exhaust channel is provided;
  • FIG. 10 is a schematic structural view of the pipe plug of the aqueous humor collection device according to an embodiment of the present invention when a peripheral wall closed and arc-shaped pipe plug exhaust channel is provided;
  • FIG. 11 is a schematic structural diagram of the liquid collection tube and the support tube frame of the aqueous humor collection device in an embodiment of the present invention when connected by a buckle;
  • FIG. 12 is a schematic structural view of the liquid collection tube of the aqueous humor collection device in an embodiment of the present invention when a convex point-like limit protrusion is integrally formed;
  • Fig. 13 is a schematic structural diagram of the liquid collection tube of the aqueous humor collection device in an embodiment of the present invention when a corrugated stop protrusion is integrally formed;
  • FIG. 14 is a schematic structural diagram of the liquid collection tube of the aqueous humor collection device according to an embodiment of the present invention when the tube kit is sheathed and the limiting protrusion is in the shape of a convex point;
  • 15 is a schematic structural diagram of the liquid collection tube of the aqueous humor collection device in an embodiment of the present invention when the tube kit is sheathed and the limiting protrusion is corrugated;
  • 16 is a schematic structural diagram of the liquid collection tube of the aqueous humor collection device according to an embodiment of the present invention when the tube kit is sheathed and the limiting protrusion is in the shape of an oblique tooth;
  • FIG. 17 is a schematic structural diagram of the supporting tube frame of the aqueous humor collection device in an embodiment of the present invention when a convex point-like limiting protrusion is integrally formed;
  • FIG. 18 is a schematic structural view of the supporting tube frame of the aqueous humor collection device in an embodiment of the present invention when a corrugated limiting protrusion is integrally formed;
  • FIG. 19 is a schematic structural view of the supporting tube frame of the aqueous humor collection device in an embodiment of the present invention when the oblique tooth-shaped limiting protrusion is integrally formed;
  • 20 is a schematic structural view of the supporting tube frame of the aqueous humor collection device in an embodiment of the present invention when the tube kit is sheathed and the limiting protrusion is in the shape of a convex point;
  • 21 is a schematic structural view of the supporting tube frame of the aqueous humor collection device in an embodiment of the present invention when the tube kit is sheathed and the limiting protrusion is corrugated;
  • FIG. 22 is a schematic structural diagram of the supporting tube frame of the aqueous humor collection device in an embodiment of the present invention when the tube kit is sheathed and the limiting protrusion is in the shape of a helical tooth.
  • the present invention provides an aqueous humor collection device 100, which includes an outer cylinder 1, a puncture needle 2, and a collection tube assembly 3.
  • the outer cylinder 1 is provided with a puncture needle installation end and a liquid sampling tube installation end at both ends in the axial direction.
  • the puncture needle 2 can be fixedly installed at the installation end of the puncture needle, and the fixed installation can be a fixed connection or a detachable connection.
  • the puncture needle may be provided with an inner end of the puncture needle located in the cavity of the outer cylinder and an outer end of the puncture needle located outside the cavity of the outer cylinder.
  • the sampling tube assembly 3 may include a sampling tube 31 inserted from the installation end of the sampling tube into the barrel cavity of the outer cylinder and capable of being inserted and removed in the axial direction, and arranged in the outer cylinder cavity for sealing the sampling tube. ⁇ 33 ⁇ Port of the pipe plug 33.
  • the tube plug 33 is in direct contact with the inner peripheral wall of the outer cylinder while the sampling tube 31 is not in direct contact with the inner peripheral wall of the outer cylinder.
  • the tube plug 33 forms a slidable contact with the inner peripheral wall of the outer cylinder, such as a slidable contact with a certain contact resistance, to control the insertion and removal of the liquid sampling tube 31 along the axial direction of the outer cylinder cavity and keep it stable Sex.
  • the static friction coefficient between the tube plug 33 and the inner peripheral wall of the outer cylinder is ⁇ 1
  • the static friction coefficient between the tube plug 33 and the nozzle of the liquid sampling tube is ⁇ 2, and satisfies: ⁇ 1 ⁇ 2.
  • the pipe plug 33 may be spaced apart from the inner peripheral wall of the outer cylinder to ensure that the pipe plug 33 and the inner peripheral wall of the outer cylinder do not directly contact each other.
  • the liquid sampling tube 31 is in direct contact with the inner peripheral wall of the outer cylinder, and the tube plug 33 is not in direct contact with the inner peripheral wall of the outer cylinder.
  • the liquid sampling tube 31 (for example, the outer periphery of the nozzle of the liquid sampling tube) may form a slidable contact with the inner peripheral wall of the outer cylinder, such as a slidable contact with a certain contact resistance, to control the liquid sampling tube along the outer cylinder.
  • the cylinder cavity moves axially and maintains its stability.
  • the pipe plug 33 and the liquid sampling tube 31 are arranged at intervals on the inner peripheral wall of the outer cylinder to ensure that the plug 33 and the liquid sampling tube 31 and the inner peripheral wall of the outer cylinder do not directly contact each other.
  • the aqueous humor collection device may include a support tube frame 32 for fixed installation of the liquid collection tube 31.
  • the outer peripheral wall of the support tube frame forms a slidable contact with the inner peripheral wall of the outer cylinder, such as a slidable contact with a certain contact resistance.
  • the fluid collection tube assembly 3 can be moved toward the inner end of the puncture needle, so that the inner end of the puncture needle is soft
  • the sleeve 8 and the tube plug 33 are inserted into the lumen of the liquid collection tube to drain the aqueous humor in the anterior chamber to the lumen of the liquid collection tube through the outer end of the puncture needle and the inner end of the puncture needle.
  • a marking line can be provided on the liquid sampling tube 31 to mark the optimal moving distance of the liquid sampling tube 31, so that when the inner end of the puncture needle pierces the tube plug 33, the finger does not need to exert excessive force to affect the liquid sampling tube and the tube.
  • the aqueous humor collection device may include a limiting protrusion 6 to facilitate the stability of the liquid collection tube and the tube plug along the axial movement of the outer cylinder cavity.
  • the sampling tube assembly 3 can be pulled out from the outer cylinder cavity as a whole, and then the sampling tube 31 can be directly placed in a specific testing instrument for specific item testing, and Compared with the prior art, there is no need to further transfer the collected aqueous humor, so the aqueous humor in the lumen of the liquid collection tube can be prevented from contacting the external environment, and the purity of the collected aqueous humor can be guaranteed, thereby improving the accuracy of subsequent detection. Performance and reliability, and can avoid the waste caused by the transfer of aqueous humor.
  • the static friction coefficient ⁇ 1 between the pipe plug 33 and the inner peripheral wall of the outer cylinder is smaller than the static friction coefficient between the pipe plug 33 and the nozzle of the sampling tube, which is ⁇ 2, or the pipe plug 33 is spaced apart from
  • the inner peripheral wall of the outer cylinder is arranged to ensure that when the liquid sampling tube assembly 3 is pulled out from the outer cylinder cavity as a whole, the pipe plug 33 will always tightly block the nozzle of the liquid sampling tube, thereby more reliably ensuring the collected room The purity of the water.
  • the pipe plug 33 and the inner peripheral wall of the outer cylinder are preferably arranged in contact with each other through a smooth surface.
  • the radially outer end surface of the pipe plug 33 or the inner peripheral wall surface of the outer cylinder can be set as a smooth surface, or the radial outer end surface of the pipe plug 33 and the inner peripheral wall surface of the outer cylinder can be set as smooth surfaces at the same time.
  • the aqueous humor collection device 100 includes an anti-sloshing structure for limiting the displacement of the sampling tube assembly 3 along the radial direction of the outer cylinder cavity.
  • the anti-sloshing structure helps the liquid sampling tube assembly to move in the axial direction during the plug-in movement process without or without radial sloshing.
  • the liquid sampling tube assembly 3 only moves in the axial direction during the insertion and removal movement without radial shaking, which not only ensures that the inner end of the puncture needle accurately pierces the tube plug during the puncture process 33 to be inserted into the lumen of the liquid collection tube, which can ensure that the liquid collection tube assembly 3 is stably pulled out after the aqueous humor collection is completed, so as to avoid the leakage of aqueous humor in the liquid collection tube lumen, thereby further improving the accuracy of subsequent detection Sex and reliability.
  • the anti-sloshing structure may include an annular groove 35 formed on the outer peripheral wall of the liquid sampling tube assembly 3 and an annular stopper 37 provided in the hoop annular groove 35 , The radially outer end of the annular stopper 37 abuts against the inner peripheral wall of the outer cylinder. It should be noted that, in addition to preventing the radial sloshing of the liquid sampling tube assembly 3, the annular stopper 37 can make the inner end of the puncture needle pierce the tube plug 33 more accurately and prevent deviation during the puncture process.
  • the stability and reliability of the puncture drainage process are effectively improved.
  • the liquid sampling tube assembly 3 can be prevented from being separated from the outer cylinder when the aqueous humor collection device 100 is taken, thereby improving the reliability of the product.
  • multiple sets of annular grooves 35 and corresponding annular stoppers 37 can be provided to obtain better effects.
  • the aqueous humor collection method of the present invention includes pushing the rear end of the liquid collection tube assembly to move the liquid collection tube toward the inner end of the puncture needle after the outer end of the puncture needle penetrates the anterior chamber of the eye, so that the puncture needle The inner end pierces the soft sleeve 8 and the tube plug 33 and then is inserted into the lumen of the liquid collection tube.
  • the soft sleeve originally covering the inner end of the puncture needle inserted into the lumen of the liquid collection tube is compressed by the tube plug to generate resilience.
  • the pressure of the aqueous humor in the anterior chamber in the lumen of the liquid collection tube and the pressure in the anterior chamber Under the action of the difference, the outer end of the puncture needle and the inner end of the puncture needle are drained to the lumen of the liquid collection tube.
  • the pressure in the lumen and the pressure in the anterior chamber tend to reach equilibrium, and the aqueous humor gradually stops draining to the lumen of the fluid collection tube through the puncture needle.
  • the time from the insertion of the inner end of the puncture needle into the lumen of the fluid collection tube until the pressure in the lumen and the pressure in the anterior chamber reach equilibrium and/or the time required for the drainage of aqueous humor to stop is or about 1 s, 2 s, 3s, 4s, 5s, 6s, 7s, 8s, 9s, 10s, 11s, 12s, 13s, 14s, 15s, 16s, 17s, 18s, 19s, 20s, 21s, 22s, 23s, 24s, 25s, 26s, 27s, 28s, 29s, 30s or longer.
  • the aqueous humor collection method of the present invention includes keeping the inner end of the puncture needle inserted into the lumen of the liquid collection tube after the outer end of the puncture needle penetrates the anterior chamber of the eye and the inner end of the puncture needle is inserted into the lumen of the liquid collection tube Steps within a period of time.
  • keeping the inner end of the puncture needle inserted into the lumen of the liquid collection tube may include maintaining or applying an external force to the liquid collection tube assembly 3 to prevent the inner end of the puncture needle from popping out of the liquid collection tube lumen.
  • maintaining or applying an external force to the fluid collection tube assembly 3 can continue until the pressure in the lumen and the pressure in the anterior chamber reach equilibrium.
  • maintaining or applying an external force to the liquid collection tube assembly 3 can continue until the drainage of aqueous humor stops.
  • the timing starts from the insertion of the inner end of the puncture needle into the lumen of the liquid collection tube, and the insertion of the inner end of the puncture needle into the lumen of the liquid collection tube can last or last for about 1s, 2s, 3s, 4s, 5s, 6s, 7s, 8s, 9s, 10s, 11s, 12s, 13s, 14s, 15s, 16s, 17s, 18s, 19s, 20s, 21s, 22s, 23s, 24s, 25s, 26s, 27s, 28s, 29s, 30s or longer.
  • the maintenance or application of external force to the liquid collection tube assembly 3 can continue or last for about 1s, 2s, 3s, 4s, 5s, 6s, 7s, 8s, 9s, 10s, 11s, 12s, 13s, 14s, 15s, 16s, 17s, 18s, 19s, 20s, 21s, 22s, 23s, 24s, 25s, 26s, 27s, 28s, 29s, 30s or longer.
  • the collection tube assembly can rebound, so that the inner end of the puncture needle naturally ejects the collection tube assembly. Liquid pipe lumen and pipe plug.
  • the friction between the inner end of the puncture needle and the soft sleeve 8 can be reduced, and the inner end of the puncture needle and the pierced tube plug
  • the sum of the friction force between the ring 33 and the friction force between the annular limiter 37 and the inner peripheral wall of the outer cylinder is set to be less than the resilience force of the soft sleeve 8, so that the outer end of the puncture needle exits the anterior chamber and the index finger loosens the extraction fluid pipe assembly 3
  • the inner end of the posterior puncture needle can naturally eject the liquid collection tube lumen and the tube plug, and there is no need to pull out the liquid collection tube assembly 3 to make the inner end of the puncture needle exit the liquid collection tube lumen and the tube plug, thereby simplifying the operation.
  • the soft sleeve 8 can also be set as a spring structure or a soft sleeve containing a spring structure, which can not only ensure the stable deformation of the soft sleeve 8 during the puncture process, but also improve the stability of the rebound force of the soft sleeve 8 when it rebounds. It is further helpful for the liquid sampling tube assembly to move along the axial direction during the insertion and removal movement process, so as to reduce or avoid radial shaking.
  • the annular limiter 37 in order to reduce production difficulty and production cost, can be preferably set as an easy-to-obtain, inexpensive and good-quality rubber band or other elastic ring, and the annular limiter 37 made of elastic material It forms elastic contact with the inner peripheral wall of the outer cylinder, which can avoid excessive friction and abrasion of the inner peripheral wall of the outer cylinder.
  • a groove vent 36 penetrating along the axial direction of the outer cylinder cavity may be formed on the groove side wall of the annular groove 35, so that the outer cylinder cavity is mounted on the pipe plug 33 and the puncture needle.
  • the barrel cavity area between the ends can communicate with the atmosphere through the groove vent 36, so as to avoid the formation of a gas plug in the outer barrel cavity and affect the smooth plugging and unplugging of the liquid sampling tube assembly 3, thereby improving the aqueous humor collection device 100 The reliability of use.
  • the anti-sloshing structure may further include a limiting protrusion 6 protruding from the outer peripheral wall of the liquid sampling tube assembly 3 or from the inner peripheral wall of the outer cylinder.
  • the radial ends of 6 are respectively connected to the outer peripheral wall of the liquid sampling tube assembly 3 and the inner circumferential wall of the outer cylinder, thereby preventing the liquid sampling tube assembly 3 from sloshing radially.
  • the limiting protrusion 6 when the limiting protrusion 6 is provided on the outer peripheral wall of the liquid sampling tube assembly 3, the limiting protrusion 6 may be integrally formed on the outer peripheral wall of the liquid sampling tube 31.
  • a tube set 34 sheathed on the outer peripheral wall of the liquid sampling tube 31 can be provided in the sampling tube assembly 3, and the limiting protrusion 6 can be provided on the outer peripheral wall of the tube set 34, because the tube set 34 is detachable Therefore, it can be reused, and it is relatively less difficult to form the limiting protrusion 6 on the tube sleeve 34, which is more conducive to reducing production costs.
  • the tube set 34 may be configured as an elastic tube set to prevent the liquid collection tube 31 from rupturing due to rigid contact when subjected to a radial restriction, thereby reducing the risk of aqueous humor leakage.
  • the anti-sloshing structure may include a plurality of limiting protrusions 6 arranged at intervals in the circumferential direction to ensure that the liquid sampling tube 31 is coaxially arranged with the outer cylinder cavity, thereby ensuring that the liquid sampling tube 31 is arranged along the Axial smooth plug-in movement.
  • a vent gap is formed between the plurality of spacing protrusions 6 spaced apart, the barrel cavity of the outer cylinder body between the puncture needle installation end and the pipe plug 33 can communicate with the atmosphere through the vent gap , Thereby avoiding the formation of a gas plug in the cavity of the outer cylinder and affecting the smooth insertion and removal of the liquid sampling tube assembly 3.
  • a plurality of limiting protrusions 6 arranged at intervals along the circumferential direction may be arranged in a convex point shape.
  • the limiting protrusion 6 can also be continuously extended in the circumferential direction.
  • an exhaust gap is preferably formed between the limiting protrusion 6 and the outer peripheral wall of the liquid sampling tube assembly 3 to avoid the formation of a gas plug.
  • an exhaust gap is also preferably formed between the limiting protrusion 6 and the inner peripheral wall of the outer cylinder.
  • the limiting protrusions 6 continuously extending in the circumferential direction may be arranged in a corrugated shape or a helical tooth shape.
  • the limiting protrusions 6 are arranged at intervals along the tube length direction of the liquid sampling tube assembly 3, or they are continuously extended and formed along the tube length direction.
  • the liquid sampling tube assembly 3 further includes a supporting tube frame 32 for fixing the liquid sampling tube 31.
  • the anti-sloshing structure can be arranged between the outer peripheral wall of the support pipe frame 32 and the inner peripheral wall of the outer cylinder, for example, as shown in FIGS. 17 to 22.
  • the supporting tube frame 32 can better improve the stability of the liquid sampling tube assembly 3 and reduce the risk of the liquid sampling tube assembly 3 being broken due to collision or pressing.
  • the liquid sampling tube needs to be taken out separately, so the connection between the liquid sampling tube 31 and the support tube frame 32 must meet the requirements of stability and quick disassembly.
  • the liquid sampling tube 31 and the support tube frame 32 can be fixed by screw connection or snap connection.
  • the sampling tube 31 and the supporting tube frame 32 are connected by a snap.
  • the sampling tube 31 needs to be inserted into the supporting tube frame 32, the sampling tube 31 is pushed to the right until the tube The rack buckle 321 is clamped into the liquid collection tube clamping groove 311, so that the liquid collection tube 31 and the supporting tube rack 32 can be locked and locked with each other.
  • the tube rack buckle button 322 can be pressed to lift the tube rack buckle 321 to escape the liquid sampling tube clamping groove 311, and the liquid sampling tube 31 can be quickly taken out from the supporting tube rack 32.
  • the aqueous humor collection device 100 further includes a needle holder 4 for fixing the puncture needle 2.
  • the outer end of the puncture needle protrudes from the outer end of the needle holder and the inner end of the puncture needle protrudes from the inner end of the needle holder, and a quick plug-in connection is formed between the inner end of the needle holder and the installation end of the puncture needle, which helps reduce the difficulty of installation. Thereby improving assembly efficiency.
  • a threaded connection or a snap connection can be formed between the inner end of the needle holder and the mounting end of the puncture needle.
  • the aqueous humor collection device 100 further includes an anti-puncture spacer 5, which is used to isolate the inner end of the puncture needle and the tube plug 33 from each other along the axial direction of the outer cylinder cavity. This prevents the inner end of the puncture needle from piercing the tube plug 33 when the aqueous humor collection device 100 is not used for anterior chamber puncture, which effectively prevents the device from failing before being used.
  • the puncture-proof partition 5 can prevent the aqueous humor collection device 100 from failing.
  • the anti-puncture spacer 5 is set as a detachable piece, and the anti-puncture spacer 5 can be removed before the puncture.
  • a spacer inserting groove 11 can be provided on the peripheral wall of the outer cylinder 1, and the spacer inserting groove 11 and the outer cylinder cavity are in the cylindrical cavity between the inner end of the puncture needle and the pipe plug 33.
  • the areas communicate with each other, and the anti-puncture spacer 5 can be inserted into the barrel cavity area through the spacer insertion slot 11, and placed between the inner end of the puncture needle and the tube plug 33, thereby connecting the inner end of the puncture needle and the tube plug 33 33 are isolated from each other.
  • the puncture-proof spacer 5 needs to be removed, it can be quickly pulled out from the spacer insertion slot 11, which is quite convenient for operation.
  • the aqueous humor collection device 100 further includes a detachable limit structure to prevent the inner end of the puncture needle from piercing the pipe plug due to vibration or misoperation by medical personnel during transportation, causing the aqueous humor collection device 100 fails and/or the liquid sampling tube assembly 3 falls off from the outer cylinder.
  • the limiting structure is located at the rear end of the supporting pipe rack.
  • the limit structure is located at the installation end of the liquid collection tube of the outer cylinder.
  • the limiting structure in a packaged or unused aqueous humor collection device, at least a part of the limiting structure is located between the installation end of the liquid sampling tube of the outer cylinder and the rear end of the supporting tube frame.
  • the limiting structure may include The blocking block sleeved at the back end of the support tube frame is clamped between the installation end of the liquid sampling tube of the outer cylinder and the back end of the support tube frame.
  • the limiting structure can prevent the relative displacement of the supporting tube frame and the outer cylinder in the axial direction, so as to prevent the inner end of the puncture needle from piercing the tube plug 33 when the aqueous humor collection device 100 is not used for anterior chamber puncture. , And/or prevent the liquid sampling tube assembly 3 from falling off the outer cylinder due to gravity or external force.
  • the limiting structure is a detachable piece, which can be removed before puncturing.
  • the tube plug 33 in order to better avoid the formation of a gas plug in the cavity of the outer cylinder and affecting the smooth insertion and removal of the liquid sampling tube assembly 3, the tube plug 33 can be placed radially outward
  • the rim forms a pipe plug exhaust passage 331 arranged along the extension direction of the outer barrel cavity, and the barrel cavity area of the outer barrel cavity between the pipe plug 33 and the puncture needle installation end can pass through the pipe plug exhaust passage 331
  • the peripheral wall exhaust gap between the above-mentioned liquid sampling tube 31 and the inner peripheral wall of the outer cylinder communicates with the atmosphere.
  • the barrel cavity of the outer cylinder is in the barrel cavity area between the pipe plug 33 and the puncture needle mounting end, the pipe plug exhaust passage 331 and the peripheral wall exhaust gap are in sequence connected, and the atmospheric environment is connected in sequence.
  • a plurality of pipe plugs that extend along the axial direction of the outer cylinder cavity and are arranged at intervals along the circumference of the pipe plug 33 are provided. Exhaust passage 331.
  • a pipe plug exhaust groove as a pipe plug exhaust passage 331 may be formed on the outer peripheral wall of the pipe plug 33, and the pipe plug exhaust groove is provided with a facing diameter Open to the groove on the outside.
  • the plug exhaust passage 331 may be set as an exhaust passage with an open peripheral wall.
  • the peripheral wall of the pipe plug exhaust channel 331 can be set as a closed peripheral wall, that is, the pipe plug exhaust channel 331 can be set as a peripheral wall closed exhaust channel.
  • the cross-section of the pipe plug exhaust passage 331 can be set to have different shapes such as a semicircle, a square or an arc.
  • the pipe plug 33 includes a pipe plug center portion for sealing the nozzle of the liquid extraction pipe and an outer ring portion of the pipe plug located radially outside the pipe plug center portion and provided with a pipe plug exhaust channel 331, which is To ensure internal and external ventilation, the outer ring portion of the pipe plug can be at least partially set as a loose ventilation structure, but it is still necessary to ensure that the central portion of the pipe plug has a tightness.
  • a puncture for guiding the penetration of the inner end of the puncture needle may be provided at the end of the tube plug 33.
  • the blind guide hole 332 is broken, and the outer contour shape of the inner end of the puncture needle matches the shape of the blind guide hole 332.
  • the inner end of the puncture needle and the puncture blind guide hole 332 may be set in a long tapered shape that matches with each other.
  • the peripheral wall water outlet hole 21 communicating with the needle cavity of the puncture needle 2 can be provided on the outer peripheral wall of the inner end of the puncture needle.
  • the aqueous humor can also flow out into the lumen of the liquid collection tube through the water outlet hole 21 on the peripheral wall, thereby ensuring the working reliability of the device.
  • the axial distance between the peripheral wall outlet hole 21 and the axial outlet hole 22 should not be too large, otherwise when the axial outlet hole 22 is inserted into the lumen of the liquid sampling tube, the peripheral wall outlet hole 21 is still located in the pipe plug 33 and is blocked. As a result, the water outlet hole 21 of the peripheral wall loses its effectiveness.
  • the axial distance between the hole center of the peripheral wall water outlet hole 21 and the hole center of the axial water outlet hole 22 can be preferably set to be no more than 3 mm, so as to ensure that when the axial water outlet hole 22 is inserted into the liquid collection After the tube lumen, the water outlet hole 21 of the peripheral wall can also be located in the lumen of the liquid collection tube without being blocked.
  • the outer diameter of the puncture needle 2 can be set to 0.31 mm (30G) to 0.91 mm (20G) and the inner diameter can be adjusted according to the outer diameter.
  • the outer diameter of the puncture needle 2 can be set to 0.5 mm (25G) and the inner diameter is at least about 0.232 mm.
  • the outer diameter of the puncture needle 2 is or is approximately 0.3mm, 0.4mm, 0.5mm, 0.6mm, 0.7mm, 0.8mm or 0.9mm.
  • the inner diameter of the puncture needle 2 is 0.15 mm to 0.45 mm, for example, the inner diameter of the puncture needle 2 is or is about 0.1 mm, 0.2 mm, 0.3 mm, or 0.4 mm.
  • the total length of the puncture needle 2 can be set to be 20 mm to 65 mm, for example, the total length of the puncture needle 2 is or is about 25 mm, 30 mm, 35 mm, 40 mm, 45 mm, 50 mm, 55 mm, or 60 mm.
  • the protruding length of the puncture needle 2 from the needle seat 4 can be set to be 1.5mm to 15mm, for example, 1.5mm to 5mm, 5mm to 7.5mm, 7.5mm to 10mm, 10mm to 12.5mm or 12.5mm. To 15mm, preferably 6mm.
  • the protruding length of the puncture needle 2 inwardly from the needle hub 4 can be set to 10 mm to 30 mm, for example, 10 mm to 15 mm, 15 mm to 20 mm, 20 mm to 25 mm, or 25 mm to 30 mm, preferably 15 mm.
  • the length of the part of the puncture needle 2 located in the needle seat 4 may be set to 10 mm to 20 mm, for example, 10 mm to 15 mm, or 15 mm to 20 mm, preferably 14 mm.
  • the total length of the puncture needle 2 is or about 35mm
  • the extension length from the needle hub 4 is or about 6mm
  • the extension length from the needle hub 4 inward is or about It is 15 mm
  • the length of the part located in the needle hub 4 is or approximately 14 mm.
  • the bevel angle of the needle tip of the puncture needle 2 can be set to 5° to 50°, for example, it can be set to 8°, 10°, 12°, 15°, 17°, 19°, 43°, 45°, 47°, etc.
  • the volume of the aqueous humor collected by the puncture needle 2 can be 10 ⁇ L to 100 ⁇ L, for example, can be set to 32 ⁇ L, 37.5 ⁇ L, 40 ⁇ L, 45 ⁇ L, 48 ⁇ L, 50 ⁇ L, 51 ⁇ L, 55 ⁇ L, 60 ⁇ L, 62.5 ⁇ L, 69 ⁇ L, etc. .
  • the target volume of the aqueous humor collected by the puncture needle 2 may be 10 ⁇ L to 100 ⁇ L, for example, it may be set to 32 ⁇ L, 37.5 ⁇ L, 40 ⁇ L, 45 ⁇ L, 48 ⁇ L, 50 ⁇ L, 51 ⁇ L, 55 ⁇ L, 60 ⁇ L, 62.5 ⁇ L, 69 ⁇ L. Wait.
  • the use of the aqueous humor collection device and method of the present invention contributes to the accuracy of aqueous humor collection.
  • the volume of the collected aqueous humor can reach the target volume ⁇ 1%, the target volume ⁇ 5%, and the target volume Volume ⁇ 10%, target volume ⁇ 15%, target volume ⁇ 20%, or target volume ⁇ 25%.
  • the shape of the liquid collection tube 31 is compatible with a centrifuge, and the maximum centrifugal force it can bear is 4000 g n .
  • the volume of the liquid collection tube 31 provided with the tube plug 33 (that is, the negative pressure liquid collection tube 31) can be set to 8 ⁇ L to 310 ⁇ L (for example, it can be set to 10 ⁇ L, 50 ⁇ L, 100 ⁇ L, 150 ⁇ L, 200 ⁇ L, 250 ⁇ L , 300 ⁇ L, etc.), the air pressure range can be set from 1*10 3 Pa to 1*10 4 Pa.
  • the air pressure range in the liquid collection tube 31 provided with the tube plug 33 is set to be between 8mmHg and 40mmHg, such as 8mmHg to 10mmHg, 10mmHg to 15mmHg, 15mmHg to 20mmHg, 20mmHg 25mmHg, 25mmHg to 30mmHg, 30mmHg to 35mmHg, or 35mmHg to 40mmHg.
  • the inner diameter of the liquid collection tube 31 can be set to 2.5 mm to 6 mm, the outer diameter can be set to 3 mm to 8 mm, and the tube length can be set to 20 mm to 30 mm.
  • the outer diameter of the outer cylinder body 1 can be set to 6 mm to 16 mm
  • the length of the support tube frame 32 can be set to 20 mm to 50 mm
  • the diameter of the support tube frame 32 can be set to 5 mm to 20 mm when it is a circular tube frame.
  • the outer cylinder body 1 can be made of 304 stainless steel
  • the needle holder 4, the support tube frame 32 and the soft cover 8 can all be made of PP material
  • the liquid collection tube 31 can be made of PET material
  • the position member 37 can be made of rubber.
  • the total length of the puncture needle 2 is or is about 35mm, the extension length from the needle hub 4 is or about 6mm, and the extension length from the needle hub 4 is or
  • the length of the part located in the needle seat 4 is about 15mm or about 14mm;
  • the outer diameter of the puncture needle 2 is set to 0.5mm (25G);
  • the bevel angle of the needle tip of the puncture needle 2 is set to 17° ⁇ 2°;
  • the volume of the liquid sampling tube 31 of the tube plug 33 is set to be 8 ⁇ L to 310 ⁇ L, and the air pressure range in the liquid sampling tube is set to be between 8 mmHg and 40 mmHg.
  • the present invention provides a method of collecting aqueous humor from the cornea, including:
  • the step of pushing the rear end of the liquid collection tube assembly 3 may include:
  • the aqueous humor in the anterior chamber passes through the puncture needle 2 under the pressure difference between the intraocular pressure and the negative pressure in the collection tube 31 and flows into the collection tube 31 for about 1 s, 2 s, 3 s. , 4s, 5s, 6s, 7s, 8s, 9s, 10s, 11s, 12s, 13s, 14s, 15s, 16s, 17s, 18s, 19s, 20s, 21s, 22s, 23s, 24s, 25s, 26s, 27s, 28s , 29s, 30s or longer.
  • the step of taking out the sampling tube assembly 3 from the outer cylinder 1 may include: not applying external force to the sampling tube assembly, or stopping or reducing the external force applied to the sampling tube assembly, allowing the sampling tube assembly to rebound.
  • the liquid sampling tube assembly 3 can be ejected naturally without applying external force to specifically pull out the liquid sampling tube assembly.
  • the present invention provides a method for collecting aqueous humor from the eyes of a subject, including:
  • the step of pushing the rear end of the liquid collection tube assembly 3 may include:
  • the aqueous humor in the anterior chamber passes through the puncture needle 2 under the pressure difference between the intraocular pressure and the negative pressure in the collection tube 31 and flows into the collection tube 31 for about 1 s, 2 s, 3 s. , 4s, 5s, 6s, 7s, 8s, 9s, 10s, 11s, 12s, 13s, 14s, 15s, 16s, 17s, 18s, 19s, 20s, 21s, 22s, 23s, 24s, 25s, 26s, 27s, 28s , 29s, 30s or longer.
  • the step of taking out the sampling tube assembly 3 from the outer cylinder 1 may include: not applying external force to the sampling tube assembly, or stopping or reducing the external force applied to the sampling tube assembly, allowing the sampling tube assembly to rebound.
  • the liquid sampling tube assembly 3 can be ejected naturally without applying external force to specifically pull out the liquid sampling tube assembly.
  • the present invention provides a method for collecting aqueous humor from the eyes of a subject, including:
  • the aqueous humor in the anterior chamber of the eye passes through the puncture needle 2 and flows into the liquid collection tube 31 under the pressure difference between the intraocular pressure and the negative pressure.
  • This step can continue or last for about 1s, 2s, 3s, 4s, 5s, 6s, 7s, 8s, 9s, 10s, 11s, 12s, 13s, 14s, 15s, 16s, 17s, 18s, 19s, 20s, 21s, 22s, 23s, 24s, 25s, 26s, 27s, 28s, 29s or 30s;
  • the method may further include selecting the negative pressure inside the liquid collection tube 31, which is lower than the intraocular pressure of the subject's eye.
  • the intraocular pressure of the subject is between 7mmHg and 50mmHg, for example, 7mmHg to 10mmHg, 10mmHg to 20mmHg, 20mmHg to 30mmHg, 30mmHg to 40mmHg or 40mmHg to 50mmHg.
  • the air pressure range in the liquid collection tube 31 provided with the tube plug 33 can be set between 8mmHg and 40mmHg, for example, 8mmHg to 10mmHg, 10mmHg to 15mmHg, 15mmHg to 20mmHg, 20mmHg To 25mmHg, 25mmHg to 30mmHg, 30mmHg to 35mmHg or 35mmHg to 40mmHg.
  • the air pressure range in the liquid collection tube 31 provided with the tube plug 33 is about 0.5mmHg, 1mmHg, 2mmHg, 3mmHg, 4mmHg, 5mmHg, 6mmHg lower than the intraocular pressure of the subject. , 7mmHg, 8mmHg, 9mmHg or 10mmHg.
  • the present invention provides a method of assembling the aforementioned aqueous humor collection device 100.
  • the assembling method includes assembling the pipe plug 33 and the liquid sampling tube 31 in a negative pressure box to set a negative pressure in the lumen of the liquid sampling tube.
  • the negative pressure in the negative pressure box can be adjusted to assemble liquid collection tubes with different negative pressure values.
  • the aforementioned aqueous humor collection device 100 can be provided with different models, corresponding to different negative pressure values of the liquid collection tube. According to the subject's intraocular pressure, a suitable negative pressure value of the fluid collection tube can be selected to collect aqueous humor safely and reliably.
  • first and second are only used for descriptive purposes, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of indicated technical features. Therefore, the features defined with “first” and “second” may explicitly or implicitly include at least one of the features. In the description of the present invention, "a plurality of” means at least two, such as two, three, etc., unless otherwise specifically defined.
  • the terms “installed”, “connected”, “connected”, “fixed” and other terms should be understood in a broad sense, for example, it can be a fixed connection or a detachable connection. , Or integrated; it can be mechanically connected, or it can be electrically connected or can communicate with each other; it can be directly connected or indirectly connected through an intermediate medium, it can be the internal communication of two components or the interaction relationship between two components, Unless otherwise clearly defined.
  • the specific meaning of the above-mentioned terms in the present invention can be understood according to specific circumstances.
  • the first feature “on” or “under” the second feature may be in direct contact with the first and second features, or the first and second features may be indirectly through an intermediary. contact.
  • the "above”, “above” and “above” of the first feature on the second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the level of the first feature is higher than the second feature.
  • the “below”, “below” and “below” of the second feature of the first feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the level of the first feature is smaller than the second feature.

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne un dispositif de collecte d'humeur aqueuse (100) et un procédé de collecte d'humeur aqueuse. Le dispositif de collecte d'humeur aqueuse comprend : un cylindre externe (1) pourvu d'une extrémité de montage d'aiguille de ponction (2) et d'une extrémité de montage de tuyau de collecte de liquide (31) ; une aiguille de ponction (2) montée fixe au niveau de l'extrémité de montage d'aiguille de ponction (2) et pourvue d'une extrémité interne d'aiguille de ponction (2) située dans une cavité de cylindre externe (1) et d'une extrémité externe d'aiguille de ponction (2) située à l'extérieur de la cavité de cylindre externe (1) ; un ensemble tuyau de collecte de liquide (3) comprenant un tuyau de liquide (31) qui est inséré dans la cavité de cylindre externe (1) à partir de l'extrémité de montage de tuyau de collecte de liquide (31) et qui peut être enfiché et déplacé axialement et un bouchon de tuyau (33) disposé dans la cavité de cylindre externe (1) destiné à être utilisé pour sceller une ouverture du tuyau de collecte de liquide (31). Un coefficient de frottement statique entre le bouchon de tuyau (33) et une paroi périphérique interne du cylindre externe (1) est μ1, un coefficient de frottement statique entre le bouchon de tuyau (33) et l'ouverture du tuyau de collecte de liquide (31) est μ2, et la relation μ1 < μ2 est satisfaite ; ou le bouchon de tuyau (33) est agencé séparé de la paroi périphérique interne du cylindre externe (1). Le dispositif de collecte d'humeur aqueuse (100) peut réguler la vitesse de drainage de l'humeur aqueuse dans un processus de ponction, peut éviter la contamination de l'humeur aqueuse après la collecte et les déchets provoqués par le transfert de l'humeur aqueuse, et présente une sécurité et une fiabilité élevées.
PCT/CN2019/110062 2019-07-02 2019-10-09 Dispositif de collecte d'humeur aqueuse et procédé de collecte d'humeur aqueuse WO2021000440A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
PCT/CN2020/096860 WO2021000743A1 (fr) 2019-07-02 2020-06-18 Support de réactif, ensemble appareil de test, dispositif de collecte d'humeur aqueuse et procédé de collecte d'humeur aqueuse
EP20834808.6A EP3995215A4 (fr) 2019-07-02 2020-06-18 Support de réactif, ensemble appareil de test, dispositif de collecte d'humeur aqueuse et procédé de collecte d'humeur aqueuse
JP2021577950A JP7337967B2 (ja) 2019-07-02 2020-06-18 試薬ホルダー、検出装置アセンブリー、房水採取装置及び房水採取方法
US17/624,393 US20220354468A1 (en) 2019-07-02 2020-06-18 Reagent holder, testing apparatus assembly, aqueous humor collection device and aqueous humor collection method
IL289549A IL289549A (en) 2019-07-02 2022-01-02 Reagent holder, test device assembly, aqueous tissue fluid collection device and method for aqueous tissue fluid collection
JP2023134836A JP2023164441A (ja) 2019-07-02 2023-08-22 試薬ホルダー、検出装置アセンブリー、房水採取装置及び房水採取方法

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
CN201910591368.2 2019-07-02
CN201921024358.2 2019-07-02
CNPCT/CN2019/094384 2019-07-02
PCT/CN2019/094383 WO2021000255A1 (fr) 2019-07-02 2019-07-02 Dispositif de collecte d'humeur aqueuse
CN201921028861.5U CN210872426U (zh) 2019-07-02 2019-07-02 房水采集装置
CN201921024358.2U CN210872425U (zh) 2019-07-02 2019-07-02 房水采集装置
CN201921024325.8 2019-07-02
CN201910591476.X 2019-07-02
CN201921024325.8U CN210872424U (zh) 2019-07-02 2019-07-02 房水采集装置
CN201921028861.5 2019-07-02
CNPCT/CN2019/094383 2019-07-02
CN201910590699.4A CN110236782B (zh) 2019-07-02 2019-07-02 房水采集装置
CN201910590699.4 2019-07-02
CN201910591476.XA CN110236784B (zh) 2019-07-02 2019-07-02 房水采集装置
PCT/CN2019/094384 WO2021000256A1 (fr) 2019-07-02 2019-07-02 Dispositif de collecte d'humeur aqueuse
CN201910591368.2A CN110236783B (zh) 2019-07-02 2019-07-02 房水采集装置

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2462854Y (zh) * 2001-01-19 2001-12-05 陈晖紘 人体工程学安全真空抽血针筒
JP2007111215A (ja) * 2005-10-20 2007-05-10 Sekisui Chem Co Ltd 採血ホルダー
CN103006241A (zh) * 2011-09-20 2013-04-03 上海兰音同医疗科技有限公司 一种安全采血针
CN204050005U (zh) * 2014-09-09 2014-12-31 赵潺 一次性负压前房穿刺针
CN110236784A (zh) * 2019-07-02 2019-09-17 北京华视诺维医疗科技有限公司 房水采集装置
CN110236782A (zh) * 2019-07-02 2019-09-17 北京华视诺维医疗科技有限公司 房水采集装置
CN110236783A (zh) * 2019-07-02 2019-09-17 北京华视诺维医疗科技有限公司 房水采集装置

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2462854Y (zh) * 2001-01-19 2001-12-05 陈晖紘 人体工程学安全真空抽血针筒
JP2007111215A (ja) * 2005-10-20 2007-05-10 Sekisui Chem Co Ltd 採血ホルダー
CN103006241A (zh) * 2011-09-20 2013-04-03 上海兰音同医疗科技有限公司 一种安全采血针
CN204050005U (zh) * 2014-09-09 2014-12-31 赵潺 一次性负压前房穿刺针
CN110236784A (zh) * 2019-07-02 2019-09-17 北京华视诺维医疗科技有限公司 房水采集装置
CN110236782A (zh) * 2019-07-02 2019-09-17 北京华视诺维医疗科技有限公司 房水采集装置
CN110236783A (zh) * 2019-07-02 2019-09-17 北京华视诺维医疗科技有限公司 房水采集装置

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