Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K6/00—Preparations for dentistry
  • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
  • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/20—Halogens; Compounds thereof
  • A61K8/21—Fluorides; Derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/25—Silicon; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/27—Zinc; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
  • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

• the present invention relates to a dental kit and a method for preventing dental caries.
• fluorine is known to have an effect of preventing caries, and glass ionomer cement containing fluoroaluminosilicate glass powder is widely used as a restoration material.
• zinc fluorine glass powder glass powder containing zinc, silicon, and fluorine (hereinafter referred to as zinc fluorine glass powder) is known (see, for example, Patent Documents 1 and 2).
• One aspect of the present invention is to provide a dental kit capable of suppressing a decrease in the amount of zinc ions eluted from a tooth restoration portion and a method for preventing dental caries.
• One aspect of the present invention includes a restoration material containing glass powder and an oral cleaning product containing zinc salt in a dental kit, and the glass powder contains zinc, silicon, and fluorine.
• Another aspect of the present invention comprises the step of cleaning the oral cavity including the teeth restored by the restoration material containing glass powder using an oral cleaning product containing zinc salt, wherein the glass powder is made of zinc. , Silicon and fluorine.
• a dental kit capable of suppressing a decrease in the amount of zinc ions eluted from a tooth restoration portion and a method for preventing dental caries.
• the dental kit of the present embodiment includes a restoration material containing zinc fluorine glass powder (hereinafter referred to as a restoration material of the present embodiment) and an oral cleaning product containing a zinc salt (hereinafter referred to as an oral cleaning product of the present embodiment).
• a restoration material containing zinc fluorine glass powder hereinafter referred to as a restoration material of the present embodiment
• an oral cleaning product of the present embodiment an oral cleaning product of the present embodiment
• the dental kit of this embodiment can be used for the treatment and prevention of dental caries.
• the tooth is restored using the restoration material of this embodiment.
• the oral cavity cleaning product of the present embodiment is used to clean the oral cavity including the teeth restored by the restoration material of the present embodiment. ..
• the zinc ion content in the tooth restoration portion decreases as time passes after the tooth is restored, and as a result, zinc ions are eluted. The amount decreases.
• the timing of cleaning the oral cavity is not particularly limited as long as it is possible to suppress a decrease in the amount of zinc ions eluted from the tooth restoration part.
• the zinc fluorine glass powder contains zinc, silicon, and fluorine, and may further contain calcium, phosphorus, strontium, lanthanum, sodium, potassium, aluminum, and the like, if necessary.
• the zinc content in the zinc fluorine glass powder is preferably 10 to 60% by mass, more preferably 20 to 55% by mass, in terms of zinc oxide (ZnO).
• the content of silicon in the zinc fluorine glass powder is preferably 15 to 50% by mass, more preferably 20 to 40% by mass, in terms of silicon oxide (SiO 2 ).
• the content of fluorine (F) in the zinc fluorine glass powder is preferably 1 to 30% by mass, and more preferably 3 to 20% by mass.
• the content of calcium in the zinc fluorine glass powder is preferably 0 to 30% by mass, more preferably 5 to 20% by mass, in terms of calcium oxide (CaO).
• the phosphorus content in the zinc fluorine glass powder is preferably 0 to 10% by mass, more preferably 0 to 5% by mass, in terms of phosphorus oxide (V) (P 2 O 5 ). preferable.
• the content of strontium in the zinc fluorine glass powder is preferably 0 to 40% by mass, more preferably 10 to 30% by mass, in terms of strontium oxide (SrO).
• the content of lanthanum in the zinc fluorine glass powder is preferably 0 to 50% by mass, more preferably 10 to 40% by mass, in terms of lanthanum oxide (La 2 O 3 ).
• the content of sodium in the zinc fluorine glass powder is preferably 0 to 15% by mass, more preferably 1 to 10% by mass, in terms of sodium oxide (Na 2 O).
• Potassium content of zinc fluorine glass powder in an amount in terms of potassium oxide (K 2 O), preferably 0 to 10 mass%, more preferably from 1 to 5 mass%.
• the content of aluminum in the zinc fluorine glass powder is preferably 0 to 35% by mass, more preferably 0 to 0.5% by mass, in terms of aluminum oxide (Al 2 O 3 ). ..
• the number average particle size of the zinc fluorine glass powder is preferably 0.01 to 30 ⁇ m, and more preferably 0.02 to 20 ⁇ m.
• the number average particle size of the zinc fluorine glass powder is 0.01 ⁇ m or more, the operability of the repair material of the present embodiment is improved, and when it is 30 ⁇ m or less, the wear resistance of the cured product of the repair material of the present embodiment is improved. Is improved.
• restoration material examples include glass ionomer cement, composite resin, temporary sealing material, and the like, and two or more of them may be used in combination.
• glass ionomer cement is preferable because zinc ions are easily eluted from the tooth restoration part into the oral cavity.
• Glass ionomer cement is a two-part composition having a first agent containing glass powder and a second agent containing a polycarboxylic acid-based polymer and water, but the glass powder and the polycarboxylic acid-based polymer It is preferable to have an aqueous solution.
• the mass ratio of the glass powder to the aqueous solution of the polycarboxylic acid polymer is preferably 1 to 5.
• the mass ratio of the glass powder to the aqueous solution of the polycarboxylic acid polymer is 1 or more, the strength of the cured product of the glass ionomer cement is improved, and when it is 5 or less, the operability of the glass ionomer cement is improved.
• Examples of commercially available glass ionomer cement include Caredyne Restoration (manufactured by GC).
• polycarboxylic acid polymer examples include homopolymers and copolymers of ⁇ , ⁇ -unsaturated carboxylic acids.
• Examples of ⁇ , ⁇ -unsaturated carboxylic acids include acrylic acid, methacrylic acid, 2-chloroacrylic acid, 3-chloroacrylic acid, aconitic acid, mesaconic acid, maleic acid, itaconic acid, fumaric acid, glutaconic acid, and citraconic acid.
• Examples include acids, and two or more of them may be used in combination. Among these, acrylic acid and itaconic acid are preferable.
• Examples of the monomer capable of copolymerizing with ⁇ , ⁇ -unsaturated carboxylic acid include acrylamide, acrylonitrile, methacrylic acid ester, acrylates, vinyl chloride, allyl chloride, vinyl acetate and the like.
• the mass ratio of ⁇ , ⁇ -unsaturated carboxylic acid to the monomer constituting the polycarboxylic acid polymer is preferably 50% or more.
• At least a part of the polycarboxylic acid-based polymer may be powder.
• the zinc salt contained in the oral cleaning product of the present embodiment is not particularly limited as long as zinc ions can be eluted into the oral cavity when cleaning the oral cavity, but for example, zinc chloride and gluconate. Examples thereof include zinc, zinc stearate, zinc myristate, zinc laurate and the like.
• oral cleaning products of the present embodiment include oral cleaning compositions such as dentifrices and mouthwashes, toothbrushes such as toothbrushes, interdental brushes, and dental floss, and two or more of them are used in combination. May be good.
• a dentifrice is preferable because zinc ions are easily taken into the restoration part of the tooth.
• the content of the zinc salt in the oral cleaning composition is preferably 0.01 to 1% by mass, more preferably 0.02 to 0.8% by mass, and 0.05 to 0.1% by mass. It is more preferably by mass%.
• the content of the zinc salt in the oral cleaning composition is 0.01% by mass or more, the decrease in the amount of zinc ions eluted from the tooth restoration can be further suppressed, and is 1% by mass or less. And, the flavor of the oral cleaning composition is improved.
• Toothpaste contains zinc salt in brushes and dental floss that come into contact with teeth when brushing teeth.
• the brush and dental floss can be produced by kneading a zinc salt using a known method.
• a method of cleaning the oral cavity using the oral cleaning product of the present embodiment for example, a method of brushing teeth using a dentifrice and / or a toothpaste, and a method of cleaning the oral cavity using a mouthwash are used.
• the method and the like can be mentioned.
• the dentifrice and / or the dentifrice contains zinc salt.
• the dentifrice may further contain an active ingredient, a wetting agent, a viscosity regulator, a solubilizer, a stabilizer, a pH regulator, a fragrance and the like.
• Examples of the active ingredient include potassium nitrate, sodium fluoride, sodium monofluorophosphate, chlorhexidine hydrochloride, isopropylmethylphenol, cetylpyridinium chloride, dipotassium glycyrrhizinate, benzethonium chloride, sodium polyphosphate, zeolite, etc. May be used together.
• wetting agent examples include sorbitol, glycerin, propylene glycol, etc., and two or more of them may be used in combination.
• viscosity modifier examples include silicic acid anhydride, hydroxyethyl cellulose, sodium carboxymethyl cellulose, xanthan gum, sodium polyacrylate, carrageenan and the like, and two or more of them may be used in combination.
• solubilizer examples include coconut oil fatty acid amide propyl betaine, polyoxyethylene hydrogenated castor oil, and the like, and two or more of them may be used in combination.
• stabilizer examples include disodium edetate, titanium dioxide and the like, and two or more of them may be used in combination.
• pH adjuster examples include sodium hydroxide, disodium hydrogen phosphate, sodium dihydrogen phosphate and the like, and two or more of them may be used in combination.
• fragrance examples include mint, menthol, peppermint oil, xylitol, sodium saccharin and the like, and two or more of them may be used in combination.
• Examples 1 to 8, Comparative Examples 1 and 2 (First agent of glass ionomer cement) Zinc oxide (ZnO), calcium fluoride (CaF 2 ), aluminum oxide (Al 2 O 3 ), silicic anhydride (SiO 2 ), calcium oxide (CaO), phosphorus oxide (P 2 O 5 ), strontium fluoride (P 2 O 5 ) After mixing SrF 2 ) and lanthanum oxide (La 2 O 3 ) in a predetermined ratio, the mixture was thoroughly mixed and stirred using a dairy pot. The resulting mixture was placed in a platinum crucible and placed in an electric furnace.
• the temperature of the electric furnace was raised to 1300 ° C., and the glass was melted to be sufficiently homogenized, and then poured into water to form a lump glass.
• the obtained lumpy glass was pulverized for 20 hours using an alumina ball mill, and then passed through a 120-mesh sieve to obtain glass powders 1 and 2.
• the glass powders 1 and 2 are zinc fluorine glass powder and fluoroaluminosilicate glass powder, respectively.
• composition of the glass powder was measured using a fluorescent X-ray analyzer ZSX Primus II (manufactured by Rigaku).
• Table 1 shows the composition [mass%] of the glass powders 1 and 2.
• the number average particle size of each of the glass powders 1 and 2 was 6 to 9 ⁇ m. ..
• the cured product of glass ionomer cement was immersed in 10 mL of distilled water at 37 ° C. for 26 hours to elute zinc ions, and then the zinc ion concentration in the eluate was C 1 [ppm] using an ICP emission spectrometer. ] Was measured.
• the cured product of glass ionomer cement was immersed in 10 mL of distilled water at 37 ° C. for 26 hours to elute zinc ions, and then the zinc ion concentration in the eluate was C 2 [ppm] using an ICP emission spectrometer. ] Was measured.
• Equation C 2- C 1 ⁇ C was determined and the change in the amount of zinc ions eluted from the hardened glass ionomer cement before and after treatment with a dentifrice was evaluated.
• Table 2 shows the evaluation results of changes in the amount of zinc ions eluted from the hardened glass ionomer cement before and after treatment with a dentifrice.
• the dental kits of Examples 1 to 8 have a large change in the amount of zinc ions eluted from the cured product of the glass ionomer cement before and after the treatment with the dentifrice. It is considered that this is because the zinc ions contained in the dentifrice were incorporated into the cured product of the glass ionomer cement from which zinc ions were eluted by immersing in the decalcification solution. Therefore, when the dental kits of Examples 1 to 8 are used, it is possible to suppress a decrease in the amount of zinc ions eluted from the tooth restoration portion.
• the dental kit of Comparative Example 1 since the dentifrice does not contain zinc salt, the amount of zinc ions eluted from the cured product of glass ionomer cement does not change before and after wiping with the dentifrice. Therefore, even if the dental kit of Comparative Example 1 is used, it is not possible to suppress a decrease in the amount of zinc ions eluted from the tooth restoration portion.
• the change in the amount of zinc ions eluted from the cured product of the glass ionomer cement is small before and after wiping with a dentifrice. ..

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• 2020
  • 2020-03-09 KR KR1020217038619A patent/KR102674595B1/ko active Active
  • 2020-03-09 WO PCT/JP2020/010035 patent/WO2020240980A1/ja not_active Ceased
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