WO2020234716A1 - Composition de matrice comprenant (s)-5-benzyl-n-(5-méthyl-4-oxo-2,3,4,5-tétrahydrobenzo [b][1,4]oxazépin-3-yl)-4 h-1,2,4-triazole-3-carboxamide - Google Patents

Composition de matrice comprenant (s)-5-benzyl-n-(5-méthyl-4-oxo-2,3,4,5-tétrahydrobenzo [b][1,4]oxazépin-3-yl)-4 h-1,2,4-triazole-3-carboxamide Download PDF

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Publication number
WO2020234716A1
WO2020234716A1 PCT/IB2020/054615 IB2020054615W WO2020234716A1 WO 2020234716 A1 WO2020234716 A1 WO 2020234716A1 IB 2020054615 W IB2020054615 W IB 2020054615W WO 2020234716 A1 WO2020234716 A1 WO 2020234716A1
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WIPO (PCT)
Prior art keywords
tablet
core
compound
film coating
modified release
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PCT/IB2020/054615
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English (en)
Inventor
Rachel APFELBAUM
Xin Chen
Rennan Pan
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Glaxosmithkline Intellectual Property Development Limited
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Priority to JP2021568636A priority Critical patent/JP2022532252A/ja
Priority to US17/610,531 priority patent/US20220218719A1/en
Priority to CA3139631A priority patent/CA3139631A1/fr
Priority to BR112021023040A priority patent/BR112021023040A2/pt
Priority to CN202080036842.6A priority patent/CN113840595A/zh
Priority to EP20727387.1A priority patent/EP3968966A1/fr
Publication of WO2020234716A1 publication Critical patent/WO2020234716A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics

Definitions

  • the present invention relates to modified release pharmaceutical compositions of a RIP1 kinase inhibitor compound and forms thereof, processes or methods of composition preparation and uses or treatment methods therefor.
  • RIP1 kinase-dependent programmed necrosis is rapidly emerging as a key pathogenic mechanism in a wide variety of inflammatory diseases, especially those driven by TNFa.
  • (S)-5-benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)- 4/-/-1 ,2,4-triazole-3-carboxamide (Compound 1 or GSK2982772), or a tautomer thereof, or a salt thereof, is a highly selective inhibitor of RIPK1.
  • QD Once daily (QD) administration with no food restrictions is considered optimal when designing oral drug products.
  • QD is the most common oral dosing regimen and most preferred by patients. Once daily administration facilitates compliance and reduces medication management issues and improves therapeutic outcomes. Twice daily dosing is also well accepted by most patients. Oral dosing regimens that require more than twice daily administration are associated with poorer adherence. In addition to dose frequency and number of dosing, dosing restrictions also play an important role. In particular, the need for co-administration with food or administration requiring the avoidance of food for a particular period of time greatly increases the complexity of managing polypharmacy and non-adherence.
  • Compound 1 may need to be administered in a manner that achieves a higher blood concentration and/or a larger area under curve (AUC).
  • AUC area under curve
  • Increasing the dose and/or increasing the frequency of dosing might be needed.
  • increasing the IR dose for Compound 1 may lead to toxicity/adverse effects and increasing frequency of dosing may lead to reduced patient adherence.
  • development of a formulation that could achieve QD dosing, other than an IR formulation was desired. Applicants describe herein a controlled-release or modified-release (MR) formulation for Compound 1 .
  • MR controlled-release or modified-release
  • MR composition which includes traditional polymer matrices, such as a hypromellose matrix and more complex multilayered matrices with or without the addition of functional excipients (used by the pharmaceutical technology industry to describe an excipient that can provide an added function or quality over and above the “conventional” excipients (http://www.pharmtech.com/excipients-forrriuiation-success), a number of approaches have been disclosed. The use of a coating to control the rate of release of an active agent has received considerable attention and many different devices have been developed for that purpose.
  • GlaxoSmithKline under the tradename of DiffCORE.
  • the approach involves using mechanical drilling of film-coated tablets, e.g., enteric-coated tablets, to form apertures of specific size, number and position in the film coat.
  • the release rate of the drug can be modified and controlled through altering the exposed surface area, the composition of the tablet core, altering the number of apertures and/or altering the position of the apertures.
  • the manufacture of tablets uses standard manufacturing unit operations such as blending, granulation and compression.
  • the invention provides a modified release pharmaceutical composition
  • a modified release pharmaceutical composition comprising an erodible matrix core, which core comprises (S)-5-benzyl-/V- (5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole-3- carboxamide, or a tautomer thereof, or a salt thereof.
  • the present invention provides a modified release
  • composition comprising an erodible matrix core, which core comprises a compound which is (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, or a salt thereof and at least one component which is a release modifier, the erodible matrix core having a film coating around said core.
  • the invention provides a modified release pharmaceutical composition
  • a modified release pharmaceutical composition comprising an erodible matrix core, which core comprises a compound which is (S)-5-benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)- 4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, or a salt thereof and at least one component which is a release modifier, the erodible matrix core having a film
  • film coating around said core, which film coating comprises at least one erodible material and at least one aperture in the film coating.
  • the invention provides a modified release pharmaceutical composition
  • a modified release pharmaceutical composition comprising an erodible matrix core, which core comprises 480mg of (S)-5-benzyl-A/-(5- methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof.
  • the invention provides a modified release pharmaceutical composition
  • a modified release pharmaceutical composition comprising an erodible matrix core, which core comprises 480mg of (S)-5- benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole- 3-carboxamide, or a tautomer thereof, and at least one component which is a release modifier, the erodible matrix core having a film coating around said core.
  • the invention provides a modified release pharmaceutical composition
  • a modified release pharmaceutical composition comprising an erodible matrix core, which core comprises 480mg of a compound which is (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, and at least one component which is a release modifier, the erodible matrix core having a film coating around said core, which film coating comprises at least one erodible material and at least one aperture in the film coating.
  • the modified release pharmaceutical composition comprises 480mg of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, and at least one component which is a release modifier, the erodible matrix core having a film coating around said core, which film coating comprises at least one erodible material and at least one aperture in the film coating, and the at least one aperture in the film coating is of a pre-determined size.
  • the invention provides a modified release pharmaceutical
  • composition comprising an erodible matrix core, which core comprises 480mg of a compound which is (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, for once daily dosing.
  • the invention provides a modified release pharmaceutical composition
  • a modified release pharmaceutical composition comprising an erodible matrix core, which core comprises 480mg of (S)-5- benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole- 3-carboxamide, or a tautomer thereof, and at least one component which is a release modifier, the erodible matrix core having a film coating around said core, for once daily dosing.
  • the invention provides a modified release pharmaceutical composition
  • a modified release pharmaceutical composition comprising an erodible matrix core, which core comprises 480mg of a compound which is (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof and at least one component which is a release modifier, the erodible matrix core having a film coating around said core, which film coating comprises at least one erodible material and at least one aperture in the film coating, for once daily dosing.
  • the modified release pharmaceutical composition for once daily dosing, comprises 480mg of (S)-5-benzyl-A/-(5-methyl-4-oxo- 2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, and the least one aperture in the film coating is of a pre-determined size.
  • the modified release pharmaceutical composition is an oral dosage form.
  • the modified release pharmaceutical composition is an oral dosage form, which oral dosage form is a tablet.
  • the modified release pharmaceutical composition is an oral dosage form, which oral dosage form is a tablet which is suitable for once daily dosing.
  • the modified release composition is administered once daily as two tablets, each tablet comprising 480mg of (S)-5-benzyl-A/-(5- methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole-3- carboxamide, or a tautomer thereof and at least one component which is a release modifier, the erodible matrix core having a film coating around said core, which film coating comprises at least one erodible material and at least one aperture in the film coating.
  • the invention provides a tablet comprising an erodible matrix core, which core comprises:
  • a film coating around said erodible matrix core comprising an erodible material in an amount of about 1 .0% wt/wt of the tablet core and about 10% wt/wt of the tablet core, and at least one aperture in the film coating.
  • the invention provides a tablet comprising an erodible matrix core, which core comprises:
  • a film coating around said erodible matrix core comprising an erodible material in an amount of about 2.0% wt/wt of the tablet core and about 6% wt/wt of the tablet core, and at least one aperture in the film coating.
  • the invention provides a tablet comprising an erodible matrix core, which core comprises:
  • the invention provides a method of treating a subject with psoriasis comprising administering to said subject a therapeutically effective amount of a compound which is (S)-5-benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/- 1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, wherein said compound is
  • modified release pharmaceutical composition comprising an erodible matrix core, which core comprises (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof.
  • the invention provides a method of treating a subject with psoriasis comprising administering to said subject a therapeutically effective amount of a compound which is (S)-5-benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin- 3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, wherein said compound is administered in a modified release pharmaceutical composition comprising an erodible matrix core, which core comprises (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof and at least one component which is a release modifier, the erodible matrix core having a film coating around
  • the invention provides a method of treating a subject with psoriasis comprising administering to said subject a therapeutically effective amount of a compound which is (S)-5-benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/- 1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, wherein said compound is administered in a modified release pharmaceutical composition comprising an erodible matrix core, which core comprises (S)-5-benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3- yl)-4H-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof and at least one component which is a release modifier, the erodible matrix core having a film coating around said core,
  • the invention provides a method of treating a subject with psoriasis comprising administering to said subject a modified release pharmaceutical composition in the form of a tablet, said tablet comprising an erodible matrix core, which core comprises, 480mg of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof and at least one component which is a release modifier, the erodible matrix core having a film coating around said core, which film coating comprises at least one erodible material and at least one aperture in the film coating, and wherein two of said tablets are administered once daily.
  • the subject is a mammal. In one embodiment of the invention, the subject is a human.
  • the invention provides a modified release pharmaceutical composition
  • a modified release pharmaceutical composition comprising an erodible matrix core, which core comprises (S)-5-benzyl-A/-(5- methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3- carboxamide, or a tautomer thereof, for use in treating psoriasis.
  • the invention provides a modified release pharmaceutical composition
  • a modified release pharmaceutical composition comprising an erodible matrix core, which core comprises (S)-5-benzyl-A/-(5- methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3- carboxamide, or a tautomer thereof and at least one component which is a release modifier, the erodible matrix core having a film coating around said core, for use in treating psoriasis.
  • the invention provides a modified release pharmaceutical composition
  • a modified release pharmaceutical composition comprising an erodible matrix core, which core comprises (S)-5-benzyl-A/-(5- methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3- carboxamide, or a tautomer thereof and at least one component which is a release modifier, the erodible matrix core having a film coating around said core, which filmcoating comprises at least one erodible material and at least one aperture in the film coating, for use in treating psoriasis.
  • the invention provides a modified release pharmaceutical composition
  • a modified release pharmaceutical composition comprising an erodible matrix core, which core comprises 480mg of (S)-5- benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole- 3-carboxamide, or a tautomer thereof and at least one component which is a release modifier, the erodible matrix core having a film coating around said core, which film coating comprises at least one erodible material and at least one aperture in the film coating, for use in treating psoriasis.
  • the invention provides a modified release pharmaceutical composition
  • a modified release pharmaceutical composition comprising an erodible matrix core, which core comprises 480mg of (S)-5- benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole- 3-carboxamide, or a tautomer thereof, in the manufacture of a medicament for use in the treatment of psoriasis.
  • the invention provides a modified release pharmaceutical composition
  • a modified release pharmaceutical composition comprising an erodible matrix core, which core comprises 480mg of (S)-5- benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole- 3-carboxamide, or a tautomer thereof and at least one component which is a release modifier, the erodible matrix core having a film coating around said core, in the manufacture of a medicament for use in the treatment of psoriasis.
  • the invention provides a modified release pharmaceutical composition
  • a modified release pharmaceutical composition comprising an erodible matrix core, which core comprises 480mg of (S)-5- benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole- 3-carboxamide, or a tautomer thereof and at least one component which is a release modifier, the erodible matrix core having a film coating around said core, which filmcoating comprises at least one erodible material and at least one aperture in the film coating, in the manufacture of a medicament for use in the treatment of psoriasis.
  • the modified release pharmaceutical composition is useful in treating moderate psoriasis.
  • the modified release pharmaceutical composition is useful in treating severe psoriasis.
  • the modified release pharmaceutical composition is useful in treating moderate to severe psoriasis.
  • the modified release pharmaceutical composition is an oral dosage form.
  • the modified release pharmaceutical composition is an oral dosage form, which oral dosage form is a tablet.
  • the dosage form is a tablet having a front face and a back face. In one embodiment of the invention, there is an aperture on the front face of the dosage form. In one
  • the at least one aperture creates an exposed surface area on the dosage form.
  • the at least one aperture in the film coating is of a pre-determined size.
  • the release rate of the compound, or tautomer thereof is partially modified by altering the size of the at least one aperture in the film coating.
  • the release rate of the compound, or tautomer thereof is partially modified by altering the number of the apertures in the film coating.
  • the release rate of the compound, or tautomer thereof is partially modified by altering the size of the aperture in the film coating and altering the number of apertures in the film coating.
  • the release rate of the compound, or tautomer thereof is partially modified by altering the size of the aperture in the film coating or altering the number of apertures in the film coating.
  • the modified release pharmaceutical composition comprises a crystalline form of (S)-5-benzyl-A/-(5- methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole-3- carboxamide, or a tautomer thereof.
  • the modified release pharmaceutical composition comprises 480mg of a crystalline form of (S)-5-benzyl-A/-(5- methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole-3- carboxamide, or a tautomer thereof.
  • the modified release pharmaceutical composition is in the form of a tablet, said tablet comprising 480mg of a crystalline form of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, wherein two of such modified release tablets are administered to a subject, once daily. It will be understood that the dosage is therefore 960mg per day.
  • the modified release pharmaceutical composition is in the form of a tablet, said tablet comprising an erodible matrix core, which core comprises 480mg of a crystalline form of (S)-5-benzyl-/V- (5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole-3- carboxamide, or a tautomer thereof and at least one component which is a release modifier, the erodible matrix core having a film coating around said core, which film coating comprises at least one erodible material and at least one aperture in the film coating, and wherein two of such modified release tablets are administered once daily. It will be understood that the dosage is therefore 960mg per day.
  • Figure 1 depicts the dissolution profiles of two Minitablet modified release formulations, one with 20% w/w of Methocel K15M, and the other with 60% w/w of Methocel K15M in 0.1 N HCI with USPII.
  • Figure 2 depicts the mean concentration time plots for the IR 120mg tablet, the Minitabs modified release 8h 120mg tablet (fasted), and the Minitabs modified release 12h 120mg (fasted and standard fed); linear (Figure 2A) and semi-log (Figure 2B) scales.
  • Figure 3 depicts the mean concentration-time profile for Minitabs modified release 120mg (fastest and slowest release) and immediate release 120mg; linear ( Figure 3A) and semi-log (Figure 3B) scales.
  • Figure 4 depicts mean plasma GSK2982772 concentration-time (pg/ml) plot by formulation: IR versus 240mg DiffCORE MR-12h, MR-16h and MR-18h, fasted Part A study 209261.
  • Figure 5 depicts a dosing curve of Compound 1 (GSK2982772) 240mg tablet, DiffCORE composition vs. IR composition.
  • Figure 6 depicts a side-by-side comparison of the performance of a prototype Minitabs modified release formulation and DiffCORE MR in fasted and fed states both compared to an IR reference performance.
  • GSK2982772 is a first-in-class, highly selective, receptor-interacting protein-1 (RIP1) kinase inhibitor being developed for the treatment of a disease or disorder selected from inflammatory bowel disease, Crohn’s disease, ulcerative colitis, psoriasis, retinal detachment, retinitis pigmentosa, macular degeneration, pancreatitis, atopic dermatitis, rheumatoid arthritis, spondylarthritis, gout, juvenile idiopathic arthritis, systemic-onset juvenile idiopathic arthritis (SoJIA), systemic lupus erythematosus, Sjogren’s syndrome, systemic scleroderma, anti-phospholipid syndrome, vasculitis, osteoarthritis, non-alcohol steatohepatitis, alcohol steatohepatitis, autoimmune hepatitis autoimmune hepatobiliary diseases, primary sclerosing cholangitis,
  • the disease or disorder is selected from inflammatory bowel disease, Crohn’s disease, ulcerative colitis and psoriasis.
  • the disease is inflammatory bowel disease.
  • the disease is Crohn’s disease.
  • the disease is ulcerative colitis.
  • the disease is psoriasis.
  • the disease is mild to moderate psoriasis. In one embodiment of the invention, the disease is moderate to severe psoriasis.
  • the compound of the invention (S)-5-benzyl-A/-(5-methyl-4-oxo-2,3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, has a structure which is:
  • the invention provides a modified release pharmaceutical composition comprising a crystalline form of (S)-5-benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4- triazole-3-carboxamide, or a tautomer thereof, as described in WO 2014/125444A1 .
  • the invention provides a modified release
  • composition comprising an erodible matrix core, which core comprises a crystalline form of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof and at least one component which is a release modifier, the erodible matrix core having a film coating around said core.
  • the invention provides a modified release pharmaceutical composition
  • a modified release pharmaceutical composition comprising an erodible matrix core, which core comprises a crystalline form of (S)-5-benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4- triazole-3-carboxamide, or a tautomer thereof and at least one component which is a release modifier, the erodible matrix core having a film coating around said core, which film coating comprises at least one erodible material and at least one aperture in the film coating.
  • the invention provides a modified release pharmaceutical composition
  • a modified release pharmaceutical composition comprising an erodible matrix core, which core comprises a crystalline form of (S)-5-benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4- triazole-3-carboxamide, or a tautomer thereof and at least one component which is a release modifier, the erodible matrix core having a film coating around said core, which film coating comprises at least one erodible material and at least one aperture in the film coating, and wherein the at least one aperture in the film coating is of pre-determined size.
  • the invention provides a modified release pharmaceutical composition
  • an erodible matrix core which core comprises a compound which is (S)-5-benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4- triazole-3-carboxamide, or a tautomer thereof and at least one component which is a release modifier
  • the erodible matrix core having a film coating around said core, which film coating comprises at least one erodible material and at least one aperture in the film coating, wherein the release rate of the compound, or tautomer thereof, is partially modified by altering the size of the at least one aperture in the film coating, and wherein the compound is present in the composition in a crystalline form.
  • the invention provides a modified release pharmaceutical composition
  • an erodible matrix core which core comprises a compound which is (S)-5-benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4- triazole-3-carboxamide, or a tautomer thereof and at least one component which is a release modifier
  • the erodible matrix core having a film coating around said core, which film coating comprises at least one erodible material and at least one aperture in the film coating, wherein the release rate of the compound, or tautomer thereof, is partially modified by altering the number of apertures in the film coating, and wherein the compound is present in the composition in a crystalline form.
  • the invention provides a modified release
  • composition comprising an erodible matrix core, which core comprises a compound which is (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof and at least one component which is a release modifier, the erodible matrix core having a film coating around said core, which film coating comprises at least one erodible material and at least one aperture in the film coating., wherein the release rate of the compound, or tautomer thereof, is partially modified by altering the size of the at least one aperture in the film coating and altering the number of apertures in the film coating, and wherein the compound is present in the composition in a crystalline form.
  • the invention provides a method of treating a subject with psoriasis comprising administering to said subject, a pharmaceutical composition as described above, taken as two 480mg tablets which provide a total of 960mg of Compound 1 , once daily, each tablet comprising a crystalline form of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof.
  • the modified release pharmaceutical composition of this invention is a once daily dosage form for Compound 1 . It is the modification of the release rate of Compound 1 via the composition as described herein, which enables once daily dosing.
  • Compound 1 for the potential treatment of inflammatory diseases, including psoriasis, rheumatoid arthritis (RA) and ulcerative colitis (UC).
  • inflammatory diseases including psoriasis, rheumatoid arthritis (RA) and ulcerative colitis (UC).
  • aperture is synonymous with the terms hole, orifice, passageway, outlet, and the like.
  • the terms“fasted state”,“fasted” or“fasted dosing” are interchangeable and refer to clinical trial studies wherein participants were provided a light snack the evening before dosing and then refrained from food and drink (except water) for a minimum of 10 h before dosing to approximately 4 h after dosing.
  • high-fat meal refers to clinical trial studies wherein the participants eat a meal consisting of one fried egg, two strips of bacon, two slices of buttered bread, one hash brown, and 240 ml_ of whole milk.
  • standard meal or“standard dosing” are used interchangeable and refer to clinical trial studies wherein the participants eat 50 g cereal with 240 mL of whole milk, one croissant, and one small pot of jam.
  • the standard meal commenced 30 min prior to dosing and completed approximately 5 min before dosing. At least 90% of the meal had to be consumed for dosing to proceed.
  • the formulations used in early clinical studies included a 0.1 mg/ml_ oral solution to support doses up to 5 mg; active-pharmaceutical-ingredient (API) in HPMC capsules for doses between 5mg to 120mg; and roller-compacted IR tablets of 10, 20 and 30 mg strength.
  • API active-pharmaceutical-ingredient
  • PK pharmacokinetic
  • GSK2982772 was also dosed twice daily (BID) and thrice daily (TID). For chronic inflammatory conditions, a QD dosing option would offer greater convenience and potentially optimize compliance.
  • the following studies were conducted to evaluate the feasibility of developing a QD modified-release (MR) formulation as well as to evaluate the impact of food on selected formulations.
  • MR QD modified-release
  • a mini-tablet modified release formulation (“Minitabs MR” or“MT”) was also tested in a clinical setting.
  • Minitabs MR formulation the target range of in vitro drug release duration was 80% of drug dissolved over 10h for“fast” release and 80% of drug dissolved over 24h for“slow” release.
  • GSK2982772 was administered as 120mg Minitabs MR at the slowest (MT-12h; 80% release at 12h) and fastest (MT-8h; 80% release at 8h) release rates which represented the extremes of the achieved design space.
  • Each Minitabs MR contained 5mg of GSK2982772 (total weight 20mg) in an HPMC capsule, and a single polymer, which was adjusted between 20% and 60% weight by weight (w/w). As shown in Figure 1 , different tablet release/dissolution rates of the Minitabs MR were achieved by varying the Methocel K15M polymer level between 60% and low 20% in the formulation. Minitabs MR composition details can be found in Table 1. Table 1 : Composition of GSK2982772 Minitab (IMPD submission Study 205017)
  • Part B (N 10) evaluated once-daily dosing for 3 days with MT-12h: 120mg (fasted), 240mg (fasted), and 300mg (standard meal). See Example 5 for more details of the clinical trial study.
  • Minitab MR and IR show sustained release was achieved with the Minitab MR formulation (as illustrated in Figure 2; Figure 2A depicts the data on a linear scale and Figure 2B depicts the data on a semi-logarithmic scale). All modified-release formulations reduced maximum plasma concentration (C m ax) , delayed time to Cmax, and increased 24h concentration vs. immediate-release.
  • Bioavailability relative to immediate-release was 61 % for MT-12h and 73% for MT-8h.
  • Dosing MT-12h with a high-fat meal increased C m ax 2.25-fold and area under the plasma concentration vs. time curve (0-inf) 1 .24-fold compared with the fasted state.
  • Three days of once-daily MT-12h led to minimal accumulation of GSK2982772.
  • Minitabs MR See Figure 3; Figure 3A depicts the data on a linear scale and Figure 3B depicts the data on a semi- logarithmic scale).
  • the Minitabs MR-12h formulation when administered with a high-fat meal increased both C max and AUC. While the Minitabs MR formulations provided flatter pharmacokinetic profiles vs. the immediate-release formulation, the Minitabs MR formulations was susceptible to a food effect with a high-fat meal.
  • the time nomenclature of 12h, 16h and 18h for DiffCORE MR-12h, DiffCORE MR-16h and DiffCORE MR-18h, respectively, represent the approximate time for 80% of GSK2982772 to be released in an in-vitro dissolution test.
  • Dissolution testing was conducted using a USPII apparatus, in a two-stage dissolution test. Conditions were 0.01 N HCI, 0.4%CTAB for one hour, and then pH 6.8 phosphate buffer with 0.4% CTAB. Paddle speed was 100rpm.
  • T max increased with increasing 240mg DiffCORE MR release rate.
  • C max , AUC and C 24h values were similar across the range of 240mg DiffCORE MR release rates. Specifically, in the fasted state, T max was prolonged by 4h relative to IR; C max was reduced to approximately 14% of IR C max ; and C 24h was ⁇ 10-fold higher than for IR.
  • the invention provides a modified release tablet of the invention comprising a crystalline form of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, wherein, upon administration to a human, produces a total drug exposure across time value (AUC) of Compound 1 , which is about 30% to about 55% lower when compared to the total drug exposure across time value of Compound 1 produced by an instant release tablet.
  • AUC total drug exposure across time value
  • the modified release tablet comprising a crystalline form of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, upon administration to a human, produces a total drug exposure across time value of Compound 1 , which is about 30% to about 50% lower when compared to the total drug exposure across time value of Compound 1 , produced by an instant release tablet.
  • the invention provides a modified release tablet of the invention comprising a crystalline form of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, wherein, upon administration to a human, produces a maximum blood plasma concentration of Compound 1 , which is about 70% to about 90% lower when compared to the maximum blood plasma concentration of Compound 1 produced by an instant release tablet.
  • the modified release tablet comprising a crystalline form of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, upon administration to a human, produces a maximum blood plasma
  • the modified release tablet comprising a crystalline form of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, upon administration to a human, produces a maximum blood plasma
  • the invention provides a modified release tablet of the invention comprising a crystalline form of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, wherein, upon administration to a human, produces a blood plasma concentration at 24 hours (C24) of Compound 1 which is about 10-fold to about 25-fold lower when compared to the blood plasma concentration at 24 hours of Compound 1 produced by an instant release tablet.
  • a modified release tablet of the invention comprising a crystalline form of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, upon administration to a human, produces a blood plasma concentration at 24 hours (C24) of Compound 1 which is about 12-fold to about 18-fold lower when compared to the blood plasma concentration at 24 hours of Compound 1 produced by an instant release tablet.
  • a modified release tablet of the invention comprising a crystalline form of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, upon administration to a human, produces a blood plasma concentration at 24 hours (C24) of Compound 1 which is about 15-fold to about 18-fold lower when compared to the blood plasma concentration at 24 hours of Compound 1 produced by an instant release tablet.
  • a modified release tablet of the invention comprising a crystalline form of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, upon administration to a human, produces a blood plasma concentration at 24 hours (C24) of Compound 1 which is about 10-fold lower when compared to the blood plasma concentration at 24 hours of Compound 1 produced by an instant release tablet.
  • the invention provides a modified release tablet of the invention comprising a crystalline form of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, wherein, upon administration to a human, produces a time to maximum concentration value (T max ) of Compound 1 which is about 3 to about 4 hours greater than the time to maximum concentration value of Compound 1 produced by an instant release tablet.
  • T max time to maximum concentration value
  • the modified release tablet of the invention comprising a crystalline form of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, upon administration to a human, produces a time to maximum concentration value of Compound 1 which is about 3 hours greater than the time to maximum concentration value of Compound 1 produced by an instant release tablet.
  • the modified release tablet of the invention comprising a crystalline form of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, upon administration to a human, produces a time to maximum concentration value of Compound 1 which is about 4 hours greater than the time to maximum concentration value of Compound 1 produced by an instant release tablet.
  • a side-by-side comparison of the mean concentration-time profiles of the Minitabs MR formulation and a 240mg DiffCORE MR tablet depicts the food effect observed with the Minitabs MR formulation and the lack of a notable impact of food on C max or AUC relative to the fasted state using the DiffCORE MR 240mg with a high fat meal. See Figure 6.
  • the invention provides a modified release pharmaceutical composition
  • a modified release pharmaceutical composition comprising an erodible matrix core, which core comprises (S)-5-benzyl-A/-(5- methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole-3- carboxamide, or a tautomer thereof, or a salt thereof.
  • the present invention provides a modified release
  • composition comprising an erodible matrix core, which core comprises a compound which is (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof, or a salt thereof and at least one component which is a release modifier, the erodible matrix core having a film coating around said core.
  • the compound which is (S)-5-benzyl-A/-(5- methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole-3- carboxamide, or a tautomer thereof is a free base.
  • the modified release pharmaceutical composition comprises a crystalline form of the free base compound which is (S)-5- benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4-triazole- 3-carboxamide, or a tautomer thereof.
  • the modified release pharmaceutical composition comprises at least one component which is a release modifier, within the erodible matrix core. Release modifying polymers which may be water swellable or not, include, inter alia, cross-linked sodium carboxymethylcellulose, cross-linked
  • Release modifying gellable polymers include methylcellulose, carboxymethylcellulose, low-molecular weight hydroxypropylmethyl cellulose, hydroxyethyl cellulose, low-molecular weight polyvinyl alcohols, polyoxyethylene glycols, non-cross linked polyvinylpyrrolidone, xanthan gum, and the like.
  • Release modifying polymers simultaneously possessing swelling and gelling properties include medium-viscosity hydroxypropylmethylcellulose and medium-viscosity polyvinyl alcohols.
  • the release modifier is a cellulose polymer. In another embodiment of the invention, the release modifier is a hypromellose- hydroxypropylmethyl cellulose polymer. In a further embodiment of the invention, the release modifier is a Methocel polymer. In yet another embodiment, the release modifier is Methocel K3LV. In still another embodiment of the invention, the release modifier is Methocel K100LV. In still yet another embodiment of the invention, the release modifier is Methocel K4M. Suitably, the release modifier is a mixture of cellulose polymers.
  • the release modifier is present in the formulation in an amount between about 1 % and about 60% weight/weight of the total composition. In one embodiment of the invention, the release modifier is present in an amount between about 1 .0% and about 45% weight/weight of the total composition. In one embodiment of the invention, the release modifier is present in an amount between about 1 .0% and about 20%
  • the release modifier is present in an amount between about 20% and about 45% weight/weight of the total composition. In another embodiment of the invention, the release modifier is present in an amount of about 20% to about 25% weight/weight of the total composition. In another embodiment of the invention, the release modifier is present in an amount of about 20% weight/weight of the total composition.
  • 240mg DiffCORE MR compositions falling within the scope of the instant invention can be found in Example 1 .
  • 60mg and 480mg DiffCORE MR compositions falling within the scope of the instant invention can be found in Example 2.
  • the invention provides a film coating comprises at least one erodible material.
  • the erodible material is present in an amount between about 1 % wt/wt of the tablet and about 20% wt/wt of the tablet core.
  • the erodible material is present in an amount between about 1 % wt/wt of the tablet core to about 10% wt/wt of the tablet core.
  • the erodible material is present in an amount between about 2% wt/wt of the tablet and about 6% wt/wt of the tablet.
  • the erodible material is present in an amount between about 3.6% wt/wt of the tablet core and about 4.6% wt/wt of the tablet core. In one embodiment, the erodible material is present in an amount of about 4% wt/wt of the tablet core.
  • the erodible material creates a film coating covering about 4mg/cm 2 to about 6mg/cm 2 of the tablet surface area. In one embodiment of the invention, the erodible material film coating covers 6mg/cm 2 of the tablet surface area.
  • the erodible material of the invention includes various polymethacrylate polymers, co-processed polyvinylacetate phthalate, cellulose acetate trimellitate, cellulose acetate phthalate, shellac, hydroxypropylmethyl cellulose phthalate polymers and their copolymers.
  • the coating material is suitably selected so that it is insoluble or only slightly soluble in stomach acid i.e. , at pH 1 .5-2, and is soluble or erodible in the small intestine i.e., at around pH 5.5 or in the large intestine i.e., at around pH 7.
  • the material of the coating is erodible at pH of 4.5 or above.
  • the coating material is selected from: cellulose acetate trimellitate (CAT) dissolving at pH 4.8, polyvinyl acetate phthalate dissolving at pH 5.0, hydroxypropylmethyl cellulose phthalate dissolving at pH 5.2, hydroxypropylmethyl cellulose phthalate dissolving at pH 5.4, Acryl- EZETM dissolving at pH 5.5, AquatericTM dissolving at pH 5.8, cellulose acetate phthalate dissolving at pH 6.0, EudragitTM L30 D dissolving at pH 5.5, EudragitTM L dissolving at pH 6.0, EudragitTM S dissolving at pH 6.8, and shellac dissolving at pH 7.2.
  • CAT cellulose acetate trimellitate
  • the erodible material is selected from enteric polymers such as HPMC-AS, poly(meth)acylate polymer, e.g., Acryl-EZETM, and the like.
  • the erodible material is an enteric coating based on methacrylic acid copolymers such as EudragitTM polymers.
  • the erodible material is an enteric coating which is EudragitTM L30-D55, Plasacryl.
  • the erodible coating may be modified by addition of plasticizers or anti-tack agents. Suitable materials for this purpose include waxy materials such as glycerides, for example glyceryl monostearate, and the like.
  • the above reference to the coating being erodible includes the situation where the coating disintegrates partially or wholly, or dissolves, or becomes porous, on contact with an environmental fluid which allows the fluid to contact the core.
  • the coating disintegrates partially.
  • the coating disintegrates wholly.
  • the coating dissolves.
  • the coating becomes porous.
  • references to the core being erodible includes the situation where core disintegrates partially or wholly, or dissolves, or becomes porous, on contact with an environmental fluid which allows the fluid to contact the active agent.
  • the core disintegrates partially.
  • the core disintegrates wholly.
  • the core dissolves.
  • the core becomes porous.
  • the core may be a material which allows pH dependent erosion or disintegration of the core to release the compound, or a tautomer thereof from its matrix.
  • the seal coat may be a sub-coat or over-coat to the erodible coating.
  • the seal coat is an aqueous film coating.
  • the aqueous film coating is present in an amount of between about 1 .5% wt/wt and 2.5% wt/wt. In one embodiment of the invention, the aqueous film coating is present is an amount of about 2% wt/wt.
  • the aqueous film coating is Opadry® Beige 02B170003 is a proprietary filmcoating material purchased by GlaxoSmithKline to an agreed specification.
  • the invention provides a modified release pharmaceutical composition
  • an erodible matrix core which core comprises a compound which is (S)-5-benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4- triazole-3-carboxamide, or a tautomer thereof and at least one component which is a release modifier
  • the erodible matrix core having a film coating around said core, which film coating comprises at least one erodible material and at least one aperture in the film coating, wherein the release rate of the compound, or tautomer thereof, is partially modified by altering the size of the at least one aperture in the film coating.
  • the aperture(s) in the coating is of a pre-determined size.
  • Typical sizes for the aperture(s), when circular, to be formed in the coating are in the range about 0.5mm to about 8mm of diameter, such as 1 , 2, 3. 4 or 5mms in diameter, depending on the overall size of the tablet and the desired rate of release.
  • the at least one aperture is between about 4.0mm and about 5.5mm. In one embodiment of the invention, the at least one aperture is between about 4.5mm and about 5.0mm. In one embodiment of the invention, the at least one aperture is about 4.5mm.
  • the oral dosage form has two opposed primary surfaces, conveniently referred to as a front face and a back face.
  • there is one aperture on the front face of the oral dosage form which aperture is about 4.5mm.
  • the apertures may be located on the same face of the oral dosage form, or on opposing faces of the oral dosage form.
  • the aperture on the front face of tablet is about 4.5mm and the aperture on the back face of tablet is about 4.5mm.
  • Each aperture may be centered on the face of the tablet or off- center.
  • the aperture(s) may have any convenient geometrical shape, for example oval, round, square, but a rounded shape, e.g., substantially circular or elliptical, is generally preferred. More elaborate shapes, such as text characters or graphics, may also be formed, provided that the release rate can be made uniform in individual dosage forms.
  • the apertures(s) may be formed by methods disclosed in US Patent No. 7,923,027.
  • aperture(s) may be formed by drilling, for example using mechanical drill bits, ultrasonic cutting or laser beams, or by punches that remove the cut area. The formation of the aperture(s) may by default remove a small portion of the exposed core. It will be understood that the at least one aperture is drilled through the coating, i.e. , within the film coating, and just reaches the core but does not penetrate to core.
  • the enteric coating When a full enteric coated tablet comprising Compound 1 was tested, in some patients the enteric coating disabled any drug release (no efficacy). Typically, for DiffCORE formulations, it is the aperture size and number that controls drug release over time. For the present invention, the release rate of Compound 1 is only partially modified or controlled by the size and/or number of apertures.
  • the film coating herein protects the erodible matrix core from stomach stress, including the pH of the fluid environment. Therefore, only a small amount of drug is released in the stomach through the aperture(s) in the film coating. As the drug is released in the stomach through the aperture(s), the tablet becomes smaller assisting movement of the tablet from the stomach to the intestines. Once in the intestines, the film coating surrounding the erodible matrix core, begins to erode, thereby releasing Compound 1 in a controlled manner over an extended time period. This was unexpected given the short half-life of Compound 1 .
  • the erosion of the coating has a defined pH threshold, i.e., the coating does not substantially erode except in the intestines.
  • erosion of the coating has a defined, pre-determined pH threshold at which it dissolves.
  • the coating erodes at pH greater than about 4.5.
  • the coating erodes in the pH range from about 4.5 to about 8.
  • the coating erodes in the pH range about 5 to about 7.5.
  • Compound 1 may be incorporated into a conventional oral tablet or controlled release matrix (including both swellable and non-swellable systems).
  • the matrix is formed into cores which are then coated with an erodible material, for example an erodible coating based on a methacrylic copolymer.
  • One or more openings may then be drilled through the coatings using conventional techniques as disclosed in U.S. Pat. No. 5,004, 614.
  • the present invention finds particular use in the situation where the coating erodes in the pH conditions of the intestines. Accordingly, the present invention also provides an oral dosage form comprising an erodible matrix core which contains a compound which is (S)-5-benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4- triazole-3-carboxamide, or a tautomer thereof, the core having a coating with one or more apertures leading to the core, wherein the coating is erodible under the pH conditions prevailing in a mammalian intestine.
  • an oral dosage form comprising an erodible matrix core which contains a compound which is (S)-5-benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,
  • the invention provides a modified release pharmaceutical composition
  • an erodible matrix core which core comprises a compound which is (S)-5-benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H-1 ,2,4- triazole-3-carboxamide, or a tautomer thereof and at least one component which is a release modifier
  • the erodible matrix core having a film coating around said core, which film coating comprises at least one erodible material and at least one aperture in the film coating, wherein the release rate of the compound, or tautomer thereof, is partially modified by altering the number of apertures in the film coating.
  • the aperture(s) in the film coating there is a range of surface area covered by the aperture(s) in the film coating. In one embodiment of the invention, this range is 1 -50% of the tablet surface area. In one embodiment of the invention, the range is 5-15% of the tablet surface area.
  • the range is 12.7% of the tablet surface area. It will be understood that by modifying the number of apertures in the film coating, one can partially modify the release rate of the compound.
  • the pharmaceutical composition is an oral tablet comprising a crystalline form of GSK2982772 and a modified release eroding matrix formulation.
  • the tablets are coated with a soluble Opadry® sub-coat and a clear enteric coating of methacrylic acid copolymer.
  • the coated tablets have an aperture drilled through the coating on both faces of the tablet to enable a controlled release of drug in the acidic environment of the stomach.
  • the modified release compositions of the invention may also include diluents/compression aid such as lactose, microcrystalline cellulose, dicalcium phosphate, sucrose, mannitol, xylitol; starches, and the like, and mixtures thereof.
  • the diluent is lactose.
  • the diluent is lactose monohydrate.
  • the diluent is lactose anhydrous.
  • the diluent is a combination of lactose monohydrate and lactose anhydrous.
  • the diluent is present in an amount of about 1 % wt/wt of the tablet core to about 95% wt/wt of the tablet core. In one embodiment of the invention, the diluent is present in an amount of about 1 % wt/wt of the tablet core to about 75% wt/wt of the tablet core. In one embodiment of the invention, the diluent is present in an amount of about 10% wt/wt of the tablet core to about 50% wt/wt of the tablet core. In one embodiment of the invention, the diluent is present in an amount of about 15% wt/wt of the tablet core to about 50% wt/wt of the tablet core.
  • the diluent is present in an amount of about 15% wt/wt of the tablet core to about 30% wt/wt of the tablet core. In one embodiment of the invention, the diluent is present in an amount of about 20% wt/wt of the tablet core to about 40% wt/wt of the tablet core. In one embodiment of the invention, the diluent is present in an amount of about 20% wt/wt of the tablet core to about 25% wt/wt of the tablet core. In one embodiment of the invention, the diluent is present in an amount of about 25% wt/wt of the tablet core.
  • the modified release compositions of the invention may also include lubricants such as magnesium stearate, sodium stearyl fumarate and stearic acid.
  • the lubricant is magnesium stearate.
  • a lubricant is present in an amount of about 0.25% wt/wt to about 5.0% wt/wt of the tablet core.
  • a lubricant is present in an amount of about 0.50% wt/wt to about 3.0% wt/wt of the tablet core.
  • a lubricant is present in an amount of about 0.50% wt/wt to about 1 .0% wt/wt of the tablet core. In one embodiment of the invention, a lubricant is present in an amount of about 1 .0% wt/wt of the tablet core.
  • the modified release compositions may further comprise disintegrants, such as crosslinked polyvinylpyrrolidone (CLPVP) and sodium starch glycollate; binders such as povidone (polyvinylpyrrolidone); flow aids such as silicon dioxide or talc.
  • disintegrants such as crosslinked polyvinylpyrrolidone (CLPVP) and sodium starch glycollate
  • binders such as povidone (polyvinylpyrrolidone)
  • flow aids such as silicon dioxide or talc.
  • the core may be prepared by compressing suitable ingredients to form a compacted mass which comprises the core of the dosage form. This may be prepared using conventional excipients and formulation compression methods.
  • the core typically comprises the active agent or agents along with excipients that impart satisfactory processing and compression characteristics such as diluents, binders and lubricants. Additional excipients that may form part of the core of the device include disintegrants, flavorings, colorants, release modifying agents and/or solubilizing agents such as surfactants, pH modifiers and complexation vehicles.
  • the core may be produced according to any desired pre-selected shape such as bi-convex, hemi-spherical, near hemi-spherical, round, oval, generally ellipsoidal, oblong, generally cylindrical or polyhedral, e.g., a triangular prism shape.
  • the term "near hemispherical” is intended to be construed in the manner described in US Patent No.
  • a suitable manufacturing process for making an oral dosage form of the invention includes transferring to a high shear granulator active component GSK2982772, lactose monohydrate, and hypromellose 2208 K3LV/K100LV/K4M, which components are mixed and granulated with purified water or sterile water for irrigation. The wet mass is then dried and milled. The granules are transferred to a blender. Lactose anhydrous and magnesium stearate are added to the blender. The components are blended. The blend is compressed into tablets and the resultant tablets are coated with an aqueous film coating and an enteric coating. The coated tablets are then drilled on both the front and back tablet faces with a suitably sized aperture, preferably 4.5mm in size.
  • the core may be coated with a suitable pH dependent erodible material by any pharmaceutically acceptable coating method.
  • coating methods include coating methods disclosed in US Patent No. 7,923,027 and film coating, sugar coating, spray coating, dip coating, compression coating, electrostatic coating.
  • Typical methods include spraying the coating onto the tablet core in a rotating pan coater or in a fluidized bed coater until the desired coating thickness is achieved.
  • the coating is provided to add about 4 to 8 mg/cm2 or 5-7 mg/cm2 of dry polymer around the tablet surface area. Typically, this results in an increase in weight (relative to the core) of from about 3-10% or about 5-10% by weight.
  • the coating has a thickness in the range 0.05 to 0.5 mm.
  • the quantity of Compound 1 , or a tautomer thereof, or a salt thereof, present in the core is a "therapeutically effective amount" and means an amount of the compound sufficient to treat the patient's condition but low enough to avoid serious side effects (at a reasonable benefit/risk ratio) within the scope of sound medical judgment.
  • a therapeutically effective amount of the Compound, or a tautomer thereof, or a salt thereof will vary with the route of administration chosen; the condition being treated; the severity of the condition being treated; the age, size, weight, and physical condition of the patient being treated; the medical history of the patient to be treated; the duration of the treatment; the nature of concurrent therapy; the desired therapeutic effect; and like factors and is not limited by the process of this invention.
  • the invention provides a modified release composition comprising about 30mg to about 960mg of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof.
  • the modified release composition comprises 30mg to 480mg of (S)-5-benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin- 3-yl)-4H-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof.
  • the modified release composition comprises 30mg to 240mg of (S)-5-benzyl-/V- (5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3- carboxamide, or a tautomer thereof.
  • the modified release composition comprises 120mg to 960mg of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof.
  • the modified release composition comprises 120mg to 480mg of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof.
  • the modified release composition comprises 120mg to 240mg of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof.
  • the modified release composition comprises 480mg to 960mg of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof.
  • the modified release composition comprises 240mg to 480mg of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof.
  • the modified release composition comprises 120mg of (S)-5-benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H- 1 ,2,4-triazole-3-carboxamide, or a tautomer thereof.
  • the modified release composition comprises 240mg of (S)-5-benzyl-A/-(5-methyl-4-oxo- 2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof.
  • the modified release composition comprises 480mg of (S)-5-benzyl-A/-(5-methyl-4-oxo-2, 3,4,5- tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof.
  • the modified release composition comprises 960mg of (S)-5-benzyl-A/-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4H- 1 ,2,4-triazole-3-carboxamide, or a tautomer thereof.
  • composition comprises a crystalline form of (S)-5-benzyl-A/-(5-methyl-4- oxo-2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof.
  • Compound 1 is in the form of a free base, or a tautomer thereof.
  • the modified release pharmaceutical composition comprises 480mg of a crystalline form of (S)-5-benzyl-A/-(5-methyl-4-oxo- 2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a tautomer thereof.
  • the modified release pharmaceutical composition is administered in a dosage regimen which is sufficient to maintain control over the disorder.
  • the dosage regimen is once a day.
  • the modified release pharmaceutical composition is in the form of a tablet comprising an erodible matrix core, which core comprises 480mg of a crystalline form of (S)-5-benzyl-A/-(5-methyl-4-oxo- 2,3,4,5-tetrahydrobenzo[b][1 ,4]oxazepin-3-yl)-4/-/-1 ,2,4-triazole-3-carboxamide, or a 0 tautomer thereof and at least one component which is a release modifier, the erodible matrix core having a film coating around said core, which film coating comprises at least one erodible material and at least one aperture in the film coating, and wherein the modified release tablet is administered as two tablets, once daily.
  • the present invention also extends to formulations which are bioequivalent to the 5 tablets or formulations of the present invention in terms of both rate and extent of
  • compositions falling within the scope of the present invention are described in the 0 following Examples. These Examples are intended to be by way of illustration rather than limitation of the present invention.
  • Example 2 Composition of GSK2982772 Modified Release Coated Tablets, 60mg and 480mg
  • Example 3 Composition of GSK2982772 480mg DiffCORE Modified Release Coated Tablets
  • Example 4 Composition of GSK2982772 Modified Release Tablet, 240 mg
  • Example 5 Protocol for Clinical Trial 205017 (IR vs. Minitabs MR): A Study to Compare the Pharmacokinetics (PK) of GSK2982772 Following Administration of Different Modified Release (MR) Formulations in Capsule and MR Tablet
  • Part A A three part, non-randomized, open label study designed to assess the pharmacokinetics of GSK2982772 following administration of mini-tab modified release formulations in a capsule relative to an immediate release reference tablet formulation 15 (Part A), the pharmacokinetics of escalating, repeat doses of a selected mini-tab modified release prototype (Part B), and the pharmacokinetics of GSK2982772 following administration of modified release tablet formulations in the fed and fasted state (Part C) in healthy participants.
  • GSK2982772 MR was available as prototype MR minitablet in capsules with unit dose strength of 60 mg in Part A. Participants in Part A received a single dose of 120 mg GSK2982772 MR MT-12hour (hr) capsule (80% release at 12 hours) in fasted state in Period 1 followed by a single dose of 120 mg GSK2982772 MR MT-8-hour capsule (80% release at 8 hours) in fasted state in Period 2.
  • Period 3 participants received a single oral dose of 120 milligram (mg) GSK2982772 (4x30 mg) IR tablet in fasted state followed by a single oral dose of 120 mg GSK2982772 MR MT-12hour capsule (80% release at 12 hours) after high fat meal in Period 4. There was a washout period of 7 days between each treatment period. All doses were administered via the oral route with 240 milliliters (ml_) of water.
  • GSK2982772 IR tablet was available with unit dose strength of 30 mg and the total dose administered by participants was 120 mg (4 tablets of dose strength 30 mg) orally with 240 ml_ of water.
  • GSK2982772 Minitab MR in capsules with unit dose strength of 15, 30 or 60 mg was administered by participants for Days 1 to 3.
  • Participants in Part B received once daily dose of 120mg GSK2982772 MR MT-12hour capsule (80% release at 12 hours) in fasted state for 3 days in Period 1 followed by once daily dose of 240mg GSK2982772 MR MT-12hour capsule (80% release at 12 hours) in fasted state for 3 days in Period 2.
  • Participants received once daily dose of 300mg GSK2982772 MR MT-12hour capsule (80% release at 12 hours) in fed state (standard meal) for 3 days. There was washout period of 7 days between each treatment period. All doses were administered via oral route with 240 ml_ water.
  • GSK2982772 MR tablet with unit dose strength of 240, 360 and 480mg was administered by participants. Participants in Part C received a single dose of 240 mg GSK2982772 MR MM-12hour tablet (80% release at 12 hours) in fasted (Fast) state in
  • Period 2 participants received a single dose of 480mg GSK2982772 MR
  • MM-12-hour tablet (80% release at 12 hours) in fasted state.
  • participants received a single dose of 480mg GSK2982772 MR MM-12-hour tablet (80% release at 12 hours) in fed state followed by a single dose of 480mg GSK2982772 MR MM-12hours
  • Period 6 participants received a single dose of 240 mg GSK2982772 MR MM-12hours (80% release at 12 hours) before high-fat standard breakfast (DF). There was a washout period of 7 days between each treatment period. All doses were administered via oral route with 240 ml_ water
  • GSK2982772 IR tablet will be available with unit dose strength of 30 mg and the total dose administered by subjects was 240 mg (8 tablets of dose strength 30 mg) orally with 240 ml_ of water.
  • Example 6 A two-part, non-randomized, open label study designed to assess the pharmacokinetic profile of modified release prototype coated tablet formulations of GSK2982772 relative to an immediate release reference tablet formulation at a fixed strength (Part A) and the pharmacokinetic profile of alternative tablet strengths of the selected modified release prototype coated tablet formulation (Part B, optional) in healthy participants
  • the first study (205017) assessed MR prototypes as minitabs in capsules and matrix monolithic tablet formulations.
  • the current study evaluated DiffCORE prototype formulations with different release rates of GSK2982772. The impact of food (High-Fat breakfast) on the rate and extent of absorption of GSK2982772 was evaluated for
  • Part A of the study was a non-randomized 6 period, 6-way fixed sequence design in which 3 DiffCORE MR prototype formulations were evaluated following single dose administration in the fasted or fed state (240 mg).
  • Periods 1 , 2 and 3 evaluated MR1 (target 80% release in 12h), immediate release (IR) tablet (240 mg) and MR2 (target 80% release in 18h), respectively in the fasted state.
  • MR1 target 80% release in 12h
  • IR immediate release
  • MR2 target 80% release in 18h
  • MR2 target 80% release in 18h
  • MR1 target 80% release in 12h
  • MR3 formulation target 80% release in 16h was dosed in the fasted state. Following completion of Part A, there was an interim review to determine whether to proceed with optional Part B. It was decided to proceed with Part B using MR3 (target 80% release in 16 h) formulation.
  • Part B of the study was an open-label, non-randomized up to 7-period fixed sequence study design to evaluate MR3 (80% release in 16h) at different tablet strengths or as multiple unit doses.
  • the tablet strengths selected in Part B were based on the exposure of GSK2982772 achieved in a high dose pharmacokinetic study in which doses of the IR tablet up to 240 mg three times daily (TID) were being administered, and the bioavailability of the selected MR prototype coated tablet formulations relative to the IR tablet (from Part A).
  • three different dose levels 120 mg, 480 mg and 960 mg
  • administration of the MR prototype coated tablet formulations were either in the fed or fasted state.
  • Periods 1 and 2 evaluated dose levels of 480 mg and 960 mg, respectively in the fasted state.
  • Periods 3 and 4 evaluated 480 mg in the fed state (High Fat Meal) and 120 mg in the fasted state, respectively.
  • Period 5 evaluated the 480 mg enteric coated formulation in the fed state (High-Fat meal) and Period 6 evaluated the 480 mg formulation in the fed state (standard meal).
  • Optional Period 7 was not conducted.
  • Example 7 A multicenter, randomized, double-blind, placebo-controlled study to evaluate the benefit and safety of GSK2982772 in moderate to severe psoriasis participants
  • Plaque psoriasis is a chronic relapsing inflammatory skin disease that is characterized by keratinocyte hyper-proliferation and epidermal hyperplasia.
  • Standard treatment for psoriasis generally requires long-term use of topical therapies, psoralen and ultraviolet A (PUVA), ultraviolet B (UVB) and/or systemic immunosuppressant therapies to achieve and maintain adequate disease control.
  • PUVA psoralen and ultraviolet A
  • UVB ultraviolet B
  • systemic immunosuppressant therapies to achieve and maintain adequate disease control. This is a multicenter, randomized, double-blind study conducted in participants with moderate to severe plaque psoriasis.
  • the study will evaluate the efficacy, safety, pharmacokinetic and pharmacodynamics profile of 960 milligram (mg) GSK2982772 administered as a once daily modified release (MR) formulation. Participants will be randomized in a 2:1 ratio to receive either 960 mg GSK2982772 or placebo for 12 weeks. The duration of the study, including Screening and follow-up, will be approximately 21 weeks for each participant.
  • Psoriatic lesions will be assessed using the PASI scoring system. Erythema, induration, and scale are each graded on a 5-point scale (0-4), and the percent body Surface Area (BSA) affected is scored on a 7-point scale (0-6) for each of the 4 specified body regions (head, upper extremities, trunk, and lower extremities). The body region scores are each multiplied by a weighted factor; and the sum of the region scores give the overall PASI score. Higher scores indicate more severe disease. Secondary Outcome Measures:
  • Psoriatic lesions will be assessed using the PASI scoring system. Erythema, induration, and scale are each graded on a 5-point scale (0-4), and the percent BSA affected is scored on a 7-point scale (0-6) for each of the 4 specified body regions (head, upper extremities, trunk, and lower extremities). The body region scores are each multiplied by a weighted factor; and the sum of the region scores give the overall PASI score. Higher scores indicate more severe disease.
  • Psoriatic lesions will be assessed using the PASI scoring system. Erythema, induration, and scale are each graded on a 5-point scale (0-4), and the percent BSA affected is scored on a 7-point scale (0-6) for each of the 4 specified body regions (head, upper extremities, trunk, and lower extremities). The body region scores are each multiplied by a weighted factor; and the sum of the region scores give the overall PASI score. Higher scores indicate more severe disease
  • Psoriatic lesions will be assessed using the PASI scoring system. Erythema, induration, and scale are each graded on a 5-point scale (0-4), and the percent BSA affected is scored on a 7-point scale (0-6) for each of the 4 specified body regions (head, upper extremities, trunk, and lower extremities). The body region scores are each multiplied by a weighted factor; and the sum of the region scores give the overall PASI score. Higher scores indicate more severe disease
  • Psoriatic lesions will be assessed using the PASI scoring system. Erythema, induration, and scale are each graded on a 5-point scale (0-4), and the percent BSA affected is scored on a 7-point scale (0-6) for each of the 4 specified body regions (head, upper extremities, trunk, and lower extremities). The body region scores are each multiplied by a weighted factor; and the sum of the region scores give the overall PASI score. Higher scores indicate more severe disease. • Percentage of participants who have a Static Investigator’s Global Assessment (sIGA) score of 0 or 1 at Week 12 [ Time Frame: At Week 12 ]
  • sIGA Global Assessment
  • the Investigator or physician designee only will complete a global assessment of disease activity using the physician global assessment item.
  • the BSA affected with psoriasis will be evaluated at all study visits by the
  • GSK2982772 will be available as MR tablet at a unit dose strength of 480mg.
  • GSK2982772 matching placebo tablets will be administered via the oral route.
  • Example 8 Manufacturing Process of GSK2982772 Modified Release Prototype Coated Tablets, 240 mg and Controls

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Abstract

La présente invention concerne des compositions pharmaceutiques à libération modifiée d'un composé inhibiteur de kinase RIP1 et des formes de celui-ci, des procédés ou des procédés de préparation des compositions et des utilisations ou des procédés de traitement correspondants.
PCT/IB2020/054615 2019-05-17 2020-05-15 Composition de matrice comprenant (s)-5-benzyl-n-(5-méthyl-4-oxo-2,3,4,5-tétrahydrobenzo [b][1,4]oxazépin-3-yl)-4 h-1,2,4-triazole-3-carboxamide WO2020234716A1 (fr)

Priority Applications (6)

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JP2021568636A JP2022532252A (ja) 2019-05-17 2020-05-15 （Ｓ）－５－ベンジル－Ｎ－（５－メチル－４－オキソ－２，３，４，５－テトラヒドロベンゾ［ｂ］［１，４］オキサゼピン－３－イル）－４Ｈ－１，２，４－トリアゾール－３－カルボキサミドを含んでなるマトリックス組成物
US17/610,531 US20220218719A1 (en) 2019-05-17 2020-05-15 Matrix composition comprising (s)-5-benzyl-n-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-4h-1,2,4-triazole-3-carboxamide
CA3139631A CA3139631A1 (fr) 2019-05-17 2020-05-15 Composition de matrice comprenant (s)-5-benzyl-n-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo [b][1,4]oxazepin-3-yl)-4 h-1,2,4-triazole-3-carboxamide
BR112021023040A BR112021023040A2 (pt) 2019-05-17 2020-05-15 Composição de matriz compreendendo (s)-5-benzil-n-(5- metil-4-oxo-2,3,4,5-tetrahidrobenzo[b][1,4]oxazepin-3-il)-4h-1,2,4- triazol-3-carboxamida
CN202080036842.6A CN113840595A (zh) 2019-05-17 2020-05-15 基质组合物，其包含(S)-5-苄基-N-(5-甲基-4-氧代-2,3,4,5-四氢苯并[b][1,4]氧氮杂环庚三烯-3-基)-4H-1,2,4-三唑-3-甲酰胺
EP20727387.1A EP3968966A1 (fr) 2019-05-17 2020-05-15 Composition de matrice comprenant (s)-5-benzyl-n-(5-méthyl-4-oxo-2,3,4,5-tétrahydrobenzo [b][1,4]oxazépin-3-yl)-4 h-1,2,4-triazole-3-carboxamide

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Citations (6)

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US5004614A (en) 1988-08-26 1991-04-02 Forum Chemicals Ltd. Controlled release device with an impermeable coating having an orifice for release of drug
EP1027887A2 (fr) * 1999-02-10 2000-08-16 Pfizer Products Inc. Dispositif pour la libération du principe actif contrôlée par la matrice
US7923027B2 (en) 2000-11-08 2011-04-12 Smithkline Beecham Limited Process
WO2014125444A1 (fr) 2013-02-15 2014-08-21 Glaxosmithkline Intellectual Property Development Limited Amides hétérocycliques à utiliser en tant qu'inhibiteurs de kinase
WO2016027253A1 (fr) * 2014-08-21 2016-02-25 Glaxosmithkline Intellectual Property Development Limited Amides hétérocycliques utilisés comme inhibiteurs de la rip1 kinase en tant que médicaments
WO2016128936A1 (fr) * 2015-02-13 2016-08-18 Glaxosmithkline Intellectual Property Development Limited Formes cristallines de (s)-5-benzyl-n-(5-méthyl-4-oxo-2,3,4,5-tétrahydrobenzo[b][1,4]oxazépine-3-yl)-4h-1,2,4-triazole-3-carboxamide

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004614A (en) 1988-08-26 1991-04-02 Forum Chemicals Ltd. Controlled release device with an impermeable coating having an orifice for release of drug
EP1027887A2 (fr) * 1999-02-10 2000-08-16 Pfizer Products Inc. Dispositif pour la libération du principe actif contrôlée par la matrice
US7923027B2 (en) 2000-11-08 2011-04-12 Smithkline Beecham Limited Process
WO2014125444A1 (fr) 2013-02-15 2014-08-21 Glaxosmithkline Intellectual Property Development Limited Amides hétérocycliques à utiliser en tant qu'inhibiteurs de kinase
WO2016027253A1 (fr) * 2014-08-21 2016-02-25 Glaxosmithkline Intellectual Property Development Limited Amides hétérocycliques utilisés comme inhibiteurs de la rip1 kinase en tant que médicaments
WO2016128936A1 (fr) * 2015-02-13 2016-08-18 Glaxosmithkline Intellectual Property Development Limited Formes cristallines de (s)-5-benzyl-n-(5-méthyl-4-oxo-2,3,4,5-tétrahydrobenzo[b][1,4]oxazépine-3-yl)-4h-1,2,4-triazole-3-carboxamide

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WEISEL ET AL., PHARMACOL RES PERSPECT., 2017, pages e00365, Retrieved from the Internet <URL:https://doi.org/10.1002/prp2.365>

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US20220218719A1 (en) 2022-07-14
JP2022532252A (ja) 2022-07-13

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