WO2020203020A1 - Dispositif de mesure d'informations biologiques et procédé de mesure d'informations biologiques l'utilisant - Google Patents

Dispositif de mesure d'informations biologiques et procédé de mesure d'informations biologiques l'utilisant Download PDF

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WO2020203020A1
WO2020203020A1 PCT/JP2020/009443 JP2020009443W WO2020203020A1 WO 2020203020 A1 WO2020203020 A1 WO 2020203020A1 JP 2020009443 W JP2020009443 W JP 2020009443W WO 2020203020 A1 WO2020203020 A1 WO 2020203020A1
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posture state
parameter set
sensor
spo2
unit
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PCT/JP2020/009443
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English (en)
Japanese (ja)
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章宏 片桐
真士 山田
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旭化成株式会社
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Priority to JP2021511287A priority Critical patent/JP7228678B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters

Definitions

  • the present invention relates to a biological information measuring device and a biological information measuring method using the same.
  • Photoplethysmography is one of the methods for non-invasively monitoring the biological signal and biological information of a subject.
  • PPG is a method of monitoring changes in blood flow in a living tissue by irradiating the surface of the living body of a subject with light having a predetermined wavelength and measuring a time-series change in the amount of light reflected or transmitted therethrough. Since blood flow is affected by multiple biological systems, by measuring biological signals with PPG, for example, pulse rate (HB), heart rate variability (HRV), vascular elasticity (RI), arterial oxygen saturation Various biological indicators such as (SpO2) and local tissue oxygen saturation (rSO2) can be obtained.
  • HB pulse rate
  • HRV heart rate variability
  • RI vascular elasticity
  • rSO2 local tissue oxygen saturation
  • the vascular system changes depending on how each part of the body bends, and the body composition changes due to the movement of fat and muscle, depending on the posture and / or body movement of the subject.
  • the subject was assigned a resting posture and was forced to remain in that posture during the measurement. Therefore, if the posture of the subject changes during the measurement, the correct measurement result may not be obtained.
  • Patent Document 1 shown below discloses a technique for accurately obtaining a causal relationship between a subject's body movement and respiratory disease symptoms.
  • Patent Document 1 describes a sleep evaluation system composed of a pulse oximeter and a PC, and the pulse oximeter obtains measurement data regarding blood oxygen saturation information from a subject's measuring finger.
  • the PC includes a probe to be acquired, a 3-axis acceleration sensor that acquires measurement data related to the body movement information of the subject, and a storage unit that stores the measurement data measured by the probe and the 3-axis acceleration sensor.
  • a sleep evaluation system having a processing function of acquiring measurement data stored in the unit and analyzing the relationship between the fluctuation of blood oxygen saturation and the body movement of a subject is disclosed.
  • Patent Document 1 simply determines whether or not the blood oxygen saturation decreases in synchronization with the body movement of the subject in the diagnosis of the subject having a respiratory disease. It stopped and was not aimed at accurately determining the subject's blood oxygen saturation itself. That is, originally, the blood oxygen saturation concentration should be measured in a state where the subject takes a correct posture at rest, and the correct value should be obtained. However, in the above technique, the posture of the subject has changed. The blood oxygen saturation concentration measured and shown in this case deviates from the value that should be measured in the original ideal state.
  • the present invention provides a biological information measuring device capable of accurately calculating the biological information even when the posture and / or body movement of the subject changes, and a biological information measuring method using the same.
  • the purpose is.
  • one object of the present invention is to make a correction according to the posture and / or body movement of the subject even if the posture and / or body movement of the subject changes. It is an object of the present invention to provide a biological information measuring device capable of more accurately calculating the above and a biological information measuring method using the same.
  • the present invention for solving the above problems is configured to include the following invention-specific matters or technical features.
  • the present invention is a biological information measuring instrument.
  • the biological information measuring device may include a biological signal acquisition unit that acquires the biological signal of the subject and a posture state signal acquisition unit that acquires the posture state signal of the subject.
  • the biological signal of the subject can be output from a biological sensor including a PPG sensor. Further, the posture state signal of the subject can be output from the motion sensor.
  • the biological information measuring device further includes a posture state estimation unit that estimates the posture state of the subject based on the posture state signal acquired by the posture state signal acquisition unit, and the biological signal acquired by the biological signal acquisition unit.
  • the SpO2 calculation unit that calculates SpO2 in the reference posture state of the subject based on the posture state estimated by the posture state estimation unit.
  • the SpO2 calculation unit can calculate the SpO2 by applying a parameter set according to the estimated posture state to the absorbance ratio calculated based on the acquired biological signal.
  • the biological information measuring instrument may further include a parameter set storage unit that stores a plurality of parameter sets corresponding to a plurality of posture state models.
  • the biological information measuring device may further include a parameter set selection unit that selects one of the predetermined parameter sets corresponding to the estimated posture state from the parameter set storage unit. Then, the SpO2 calculation unit can correct the absorbance ratio based on the selected predetermined parameter set.
  • the biometric information measuring instrument selects one or two or more of the parameter sets corresponding to the estimated posture state from the parameter set storage unit, and performs interpolation based on the selected one or more parameter sets.
  • a parameter set estimation unit for estimating one parameter set may be provided by calculation. Then, the SpO2 calculation unit can correct the absorbance ratio based on the estimated one parameter set.
  • the SpO2 calculation unit can correct the absorbance ratio by the interpolation calculation using the probability density function.
  • the SpO2 calculation unit can correct the absorbance ratio by the interpolation calculation using a predetermined nonlinear function.
  • the biometric information measuring instrument may further include a parameter set estimation unit that estimates a parameter set corresponding to a specific posture state based on the estimated posture state and the absorbance ratio. Then, the parameter set estimation unit may store the estimated parameter set in the parameter set storage unit.
  • the posture state estimation unit can estimate the posture state of the subject based on the biological signal output from at least one biological sensor.
  • the at least one biosensor may include at least one of a blood pressure sensor, a pulse sensor, an ECG sensor and an myoelectric sensor.
  • the motion sensor includes at least one of a gravity sensor, an acceleration sensor, a gyro sensor, a geomagnetic sensor, a pressure sensitive sensor, an ultrasonic sensor, an infrared sensor, an image sensor, and a spectrum sensor.
  • the present invention can be a biometric information measuring method using a biometric information measuring device.
  • the method may include obtaining a biological signal of the subject and obtaining a posture state signal of the subject.
  • the biological signal of the subject can be output from a biological sensor including a PPG sensor.
  • the posture state signal of the subject can be output from the motion sensor.
  • the method also estimates the posture state of the subject based on the acquired posture state signal, and at the time of the reference posture state of the subject based on the acquired biological signal and the estimated posture state. It may include calculating SpO2.
  • the SpO2 is calculated by applying a parameter set according to the estimated posture state to the absorbance ratio calculated based on the acquired biological signal. May include.
  • the present invention can also be configured as a computer program for executing the method and a recording medium on which the method is executed in a computing device under the control of a processor.
  • the "means” does not simply mean a physical means, but also includes a means in which the function of the means is realized by software. Further, the function of one means may be realized by two or more physical means, or the function of two or more means may be realized by one physical means.
  • the "system” includes a device in which a plurality of devices (or functional modules that realize a specific function) are logically assembled, and each device or functional module is physically a single device. It does not matter whether it is composed or as a separate object.
  • the biological information can be accurately calculated.
  • FIG. 1 is a block diagram showing an example of the configuration of the biological information measuring instrument according to the embodiment of the present invention.
  • the biometric information measuring device 1 shown in the figure is a device for measuring SpO2, which is one of the biometric indexes of the subject.
  • the sensor unit 10, the control unit 20, and the user interface unit 30 communicate with each other. It includes components such as the interface unit 40.
  • the biological information measuring instrument 1 is generally referred to as a pulse oximeter, but is not limited thereto.
  • the biometric information measuring instrument 1 may be configured as an integrated type in which these components are housed in one housing (not shown), for example. Such an integrated biometric information measuring device 1 can be attached to, for example, the chest or a finger of a subject.
  • the biometric information measuring instrument 1 may be configured such that all or a part of the sensor unit 10 and the like is separate from the housing.
  • the control unit 20, the user interface unit 30, and the communication interface unit 40 may be integrally configured as one controller board or a control device main body.
  • the biometric information measuring device 1 may be configured such that a part of the functions of the control unit 20 is executed by an external device (for example, a computing device).
  • the sensor unit 10 includes, for example, at least one biosensor 12 and at least one motion sensor 14.
  • the biological sensor 12 is a sensor that observes a biological phenomenon of a subject, detects and outputs a biological signal based on the biological phenomenon.
  • the biosensor 12 typically includes a PPG sensor 12a for measuring SpO2 (see FIG. 2).
  • the PPG sensor 12a is an active unit including a light emitting unit for emitting light of two types of wavelengths (red light and infrared light) and a light receiving unit for receiving these lights. It is a sensor, and there are, for example, a transmissive type and a reflective type.
  • the PPG sensor 12a is a reflective type, but the present invention is not limited to this.
  • the reflection type PPG sensor 12a receives the reflected light (which may include scattered light, diffused light, etc.) from the living body irradiated with the light.
  • the biological signal detected by the PPG sensor 12a can be used to estimate the posture and / or body movement state (hereinafter referred to as “posture state”) of the subject.
  • the change in the biological signal detected by the PPG sensor 12a can be regarded as the change in the posture state of the subject.
  • the posture state may include a state of movement of a specific part such as raising and lowering the subject's hand and upper arm.
  • the biological sensor 12 may include at least one of a blood pressure sensor, a pulse sensor, an ECG sensor, and an electromyographic sensor. At least some of these biological sensors 12 are attached to, for example, a measurement site or location of a subject according to the characteristics of the sensor to detect biological signals. The biological signal detected by the biological sensor 12 is output to the control unit 20.
  • the motion sensor 14 is a sensor that observes the posture state of the subject, detects and outputs a signal related to the posture state (hereinafter referred to as "posture state signal").
  • a known motion sensor 14 can be used.
  • the motion sensor 14 includes a gravity sensor, an acceleration sensor, a gyro sensor (these may be collectively referred to as an "inertial sensor”), a geomagnetic sensor, a pressure sensor, an ultrasonic sensor, an infrared sensor, and an image sensor. , And at least one of the spectrum sensors.
  • the posture state signal detected by the motion sensor 14 is output to the control unit 20.
  • the motion sensors 14 are not directly attached to the subject, and may be configured and arranged so as to observe from a position away from the subject, for example.
  • the image sensor may be configured to image the subject as a camera and output the imaged signal to the biometric information measuring instrument 1 or an external computing device.
  • the control unit 20 is typically configured to include a processor 22 and a memory 24, and is a component that comprehensively controls the operation of the biometric information measuring device 1 under the control of the processor 22.
  • the memory 24 holds, for example, a processing program and various setting information.
  • the processing program may be configured to include, for example, several program modules.
  • the memory 24 is configured to store one or more parameter sets necessary for calculating SpO2, which will be described later, and to store the calculated SpO2 as a measurement result.
  • the control unit 20 collaborates with other components by executing a predetermined processing program under the control of the processor 22, calculates SpO2 based on the acquired biological signal and posture state signal, and calculates SpO2. This is stored in the memory 24 as a measurement result.
  • the control unit 20 functions as a computing device.
  • the measurement result may include, for example, a time stamp indicating the time when SpO2 was measured.
  • the calculated SpO2 is the SpO2 estimated in the reference posture state in consideration of the subject's current posture state. Details of the calculation of SpO2 will be described later.
  • the user interface unit 30 is a component that provides a user interface that functions interactively to a subject and / or a medical worker such as a doctor (hereinafter, these persons may be collectively referred to as a "user"). is there.
  • the user interface unit 30 receives, for example, an input operation from the user under the control of the processor 22, and / or displays, for example, the calculated SpO2 measurement result or the like to the user.
  • the user interface unit 30 may include a speaker, a vibrator, and the like.
  • the user interface unit 30 may be a touch panel.
  • the user can interactively operate the user interface unit 30 as a touch panel to display necessary information and make various settings of the biometric information measuring device 1.
  • the user interface unit 30 is configured as a part of the biometric information measuring device 1, but is not limited to this.
  • a part or all of the user interface unit 30 may be realized by an external computing device.
  • an external computing device is configured to be communicable with a control unit 20 via a communication interface unit 40, and a user operates a Web browser on the computing device to perform measurement results and / or the measurement results. You can refer to the analysis result for.
  • the biometric information measuring instrument 1 does not need to have the user interface unit 30, or may have a minimum configuration, and its housing size can be reduced.
  • the communication interface unit 40 is a component for connecting the biometric information measuring device 1 so as to be able to communicate with an external device.
  • the connection form between the communication interface unit 40 and the external device is not limited to wired and / or wireless, and the communication interface unit 40 adopts a configuration according to such a connection form.
  • the communication interface unit 40 may be designed in accordance with a USB standard, a Bluetooth (registered trademark) standard, a Wi-Fi (registered trademark) standard, or the like.
  • the communication interface unit 40 is defined as a USB mass storage class, and the measurement result stored in the memory 24 of the biometric information measuring device 1 is read out by an external device.
  • FIG. 2 is a block diagram for explaining the details of the control unit of the biometric information measuring instrument according to the embodiment of the present invention.
  • the control unit 20 of the biological information measuring device 1 includes, for example, a sensor control unit 201, a biological signal receiving unit 202, an attitude state signal receiving unit 203, an absorptivity ratio calculation unit 204, and an attitude state. It includes an estimation unit 205, a parameter set storage unit 206, a parameter set selection unit 207, a SpO2 calculation unit 208, and a measurement result storage unit 209.
  • the PPG sensor 12a is shown as the biosensor 12 of the sensor unit 10, and the inertial sensor 14a and the triaxial geomagnetic sensor 14b are shown as the motion sensor 14.
  • the inertial sensor 14a typically includes a 3-axis acceleration sensor and a 3-axis gyro sensor, and in combination with the 3-axis geomagnetic sensor 14b, functions as a 9-axis motion sensor.
  • the motion sensor 14 is not limited to these sensors, and may include a camera such as an image sensor or a spectrum sensor, for example.
  • the sensor control unit 201 controls the operation of the sensor unit 10. For example, the sensor control unit 201 performs light emission control for driving the light emitting unit of the PPG sensor 12a in order to start the measurement of SpO2 in accordance with the instruction from the user interface unit 30 based on the user's operation.
  • the first light emitting portion is typically a biological tissue (arterial blood).
  • the biological signal receiving unit 202 is an example of the biological signal acquisition unit, and the biological sensor 12 itself or the configuration including the biological sensor 12 and the biological signal receiving unit 202 can also be grasped as an example of the biological signal acquiring unit.
  • the biological signal receiving unit 202 outputs the received biological signal to the absorbance ratio calculation unit 204.
  • the attitude state signal receiving unit 203 receives or acquires attitude state signals output from various motion sensors 14 (in the example, the inertial sensor 14a and the geomagnetic sensor 14b), respectively.
  • the posture state signal receiving unit 203 is an example of the posture state signal acquisition unit, and the configuration including the motion sensor 14 itself or the motion sensor 14 and the posture state signal receiving unit 203 is also grasped as an example of the posture state signal acquisition unit. Can be done.
  • the attitude state signal receiving unit 203 outputs the received attitude state signal to the attitude state estimation unit 205.
  • the absorbance ratio calculation unit 204 calculates the absorbance ratio (R) to be used for calculating SpO2 based on the biological signal output from the biological signal receiving unit 202.
  • the absorbance ratio calculation unit 204 outputs the calculated absorbance ratio (R) to the SpO2 calculation unit.
  • the absorbance ratio (R) is a value calculated by a known method utilizing the difference in absorption coefficients of oxidized hemoglobin (O 2 Hb) and reduced hemoglobin (HHb) for light of different wavelengths. More specifically, the absorbance ratio (R) can be calculated by the following formula 1.
  • Red is the absorbance of the received red light (that is, the first reflected light)
  • IR is the absorbance of the received infrared light (that is, the second reflected light).
  • AC Red is the absorbance of the AC signal component (that is, the pulsating component) of the received red light Red
  • DC Red is the absorbance of the DC signal component of the received red light Red
  • AC IR is the AC signal of the received infrared light IR.
  • the absorbance of the component (that is, the pulsating component), DC IR is the absorbance of the DC signal component of the received infrared light IR.
  • the calculated absorbance ratio (R) is used for conversion to SpO2 according to the Beer-Lambert rule.
  • SpO2 is represented by the following definition formula. However, [O 2 Hb] is the oxidized hemoglobin concentration, and [HHb] is the reduced hemoglobin concentration. From this, SpO2 is calculated from the following theoretical formula in consideration of the Beer-Lambert law.
  • ⁇ HHb and Red are the molar extinction coefficient of red light Red with respect to reduced hemoglobin (HHb)
  • ⁇ O2Hb and Red are the molar extinction coefficient of red light Red with respect to oxidized hemoglobin (O 2 Hb)
  • ⁇ O2Hb and IR are hemoglobin oxide
  • ⁇ HHb, IR are the molar extinction coefficient of infrared light IR with respect to reduced hemoglobin (HHb).
  • SpO2 is calculated using a fixed parameter set linearly fitted to a region where SpO2 is 80 to 100%, for example, using the following formula and numerical value.
  • SpO2 ⁇ fix ⁇ fix ⁇ R... Equation 4
  • the biological information measuring instrument 1 of the present disclosure calculates SpO2 by using a parameter set in consideration of the posture state instead of the fixed parameter set, as described later.
  • the posture state estimation unit 205 estimates the posture state of the subject based on the posture signal output from the posture state signal receiving unit 203.
  • Postural states of the subject include, for example, the decubitus (supine and prone), sitting, and standing positions as well as the intermediate positions of these positions.
  • the posture state estimation unit 205 estimates one of the three posture states of the lying position, the sitting position (reclining), and the standing position.
  • the posture state estimation unit 205 sets the subject's posture state in a lying position. Presumed to be in a state.
  • the posture state estimation unit 205 sets the subject's posture state in a standing state. I presume.
  • the posture state estimation unit 205 sets the posture state of the subject in a sitting position. Presumed to be in a state.
  • the posture state estimation unit 205 may indicate the body position from the lying position to the standing position, for example, by an inclination angle.
  • the posture state estimation unit 205 outputs the estimated posture state to the parameter set selection unit 207. As described in other embodiments, the posture state estimation unit 205 may estimate the posture state of the subject based on the biological signal obtained from the biological sensor 12.
  • the parameter set storage unit 206 stores preset parameter sets corresponding to each of the plurality of posture state models.
  • the parameter set storage unit 206 can typically be formed as a storage area on the memory 24.
  • the parameter set includes, but is not limited to, some parameters for calculating SpO2 from the absorbance ratio (R), such as ⁇ , ⁇ , and ⁇ .
  • the parameter set is expressed as "parameter set ( ⁇ , ⁇ )" or "parameter set ( ⁇ , ⁇ , ⁇ )" as necessary.
  • the parameter set may include, for example, a recumbent parameter set corresponding to the recumbent model, a sitting parameter set corresponding to the sitting model, and a standing parameter set corresponding to the standing model. I can't.
  • these parameter sets are correction parameter sets for estimating SpO2 at the time of measurement in the reference posture state of the subject.
  • the parameter set can be defined, for example, from data empirically obtained in clinical trials and the like.
  • the parameter set selection unit 207 selects and reads at least one parameter from the plurality of parameter sets stored in the parameter set storage unit 206 based on the posture state estimated by the posture state estimation unit 205. For example, when the posture state output from the posture state estimation unit 205 indicates the sitting position state, the parameter set selection unit 207 extracts the sitting position parameter set from the parameter set storage unit 206. The parameter set selection unit 207 outputs the selected and read parameter set to the SpO2 calculation unit 208.
  • the parameter set ( ⁇ , ⁇ ) referred to here is composed of a value that considers the posture state of the subject, not a fixed value that does not consider the posture state as in the past. Therefore, by applying such a parameter set ( ⁇ , ⁇ ) to the absorbance ratio (R), SpO2 in the reference posture state, which is corrected for SpO2 in the posture state at the time of measurement, is calculated. become.
  • the SpO2 calculation unit 208 outputs the calculated SpO2 to the measurement result storage unit 209.
  • the measurement result storage unit 209 stores SpO2 output from the SpO2 calculation unit 208 as a measurement result.
  • the measurement result storage unit 209 can typically be formed as a storage area on the memory 24.
  • the user can, for example, operate the user interface unit 30 to browse the measurement results stored in the measurement result storage unit 209.
  • the posture state of the subject is observed, the optimum parameter set according to the observed posture state is selected, and the selected parameter set is calculated as the absorptivity. Since SpO2 is calculated by applying it to the ratio, it is possible to calculate SpO2 in the reference posture state, which is corrected for SpO2 in the posture state at the time of measurement.
  • the optimum parameter set is estimated from the preset parameter set according to the posture state estimated by the observation, and the estimated parameter set is calculated.
  • a biometric information measuring instrument for calculating SpO2 and a measuring method using the biometric information measuring instrument will be described by applying the absorptivity ratio.
  • FIG. 3 is a block diagram showing an example of the configuration of the biological information measuring instrument according to the embodiment of the present invention.
  • the biometric information measuring device 1 according to the present embodiment is different from the biometric information measuring device 1 according to the first embodiment in that a parameter set estimation unit 210 is provided instead of the parameter set selection unit 207. .. Further, the posture state estimation unit 205 of the present embodiment is configured to estimate the posture state based on the measured tilt angle, instead of selectively specifying the preset posture state.
  • the posture state estimation unit 205 estimates and outputs the posture state based on the posture state signal output from the posture state signal receiving unit 203. For example, the posture state estimation unit 205 identifies the posture state by the inclination angle between the lying position and the sitting position or the inclination angle between the sitting position and the standing position based on the posture state signal. The posture state estimation unit 205 outputs the posture state indicated by the tilt angle to the parameter set estimation unit 210.
  • the parameter set estimation unit 210 estimates the optimum parameter set to be used for calculating SpO2 based on the tilt angle output from the posture state estimation unit 205.
  • the parameter set estimation unit 210 is configured so that, for example, a parameter mixing ratio conversion map (hereinafter referred to as “mixing ratio conversion map”) as shown in FIG. 4A can be referred to.
  • the parameter mixing ratio indicates the ratio (weight) of mixing the corresponding parameters in different parameter sets.
  • the mixed ratio conversion map may be held in a predetermined storage area of the memory 24 with a predetermined data structure, or may be configured as a part of the parameter set estimation unit 210.
  • the mixing ratio conversion map is defined so that the mixing ratio changes non-linearly in relation to the tilt angle.
  • the parameter set estimation unit 210 extracts one or more parameter sets from the parameter set storage unit 206 according to the tilt angle. For example, when the tilt angle is 30 degrees between the recumbent position and the sitting position, the parameter set estimation unit 210 extracts the recumbent position parameter set and the sitting position parameter set set adjacent to the tilt angle. Subsequently, the parameter set estimation unit 210 refers to the corresponding mixing ratio conversion map, determines the mixing ratio between the extracted parameter sets from the inclination angle, and calculates the parameter set according to the determined mixing ratio.
  • the parameter set estimation unit 210 outputs the calculated parameter set to the SpO2 calculation unit 208 in the same manner as in the first embodiment.
  • the SpO2 calculation unit 208 is based on the absorbance ratio (R) output from the absorbance ratio calculation unit 204 and the parameter set ( ⁇ , ⁇ ) output from the parameter set selection unit 207, as in the first embodiment. To calculate SpO2.
  • the posture state is estimated by the tilt angle based on the posture state signal, one or two or more parameter sets are extracted according to the estimated tilt angle, and the mixing ratio is obtained.
  • the mixing ratio is determined from the tilt angle with reference to the conversion map, and the optimum parameter set is estimated or calculated using the determined mixing ratio. Therefore, more accurate SpO2 can be obtained regardless of the posture state of the subject. You will be able to calculate.
  • Example 2-1 modeling of a non-linear mixing ratio conversion map as shown in FIG. 4B will be described. However, in this example, for the sake of simplification of the explanation, it is between the lying position and the standing position (however, the supine position to the standing position to the prone position (prone position), and the supine position to the standing position and the standing position to the lying position).
  • the parameter set estimation unit 210 estimates the optimum parameter set by using one or more parameter sets according to the estimation model described here.
  • the parameter set estimation unit 210 estimates the optimum parameter set with reference to such a mixing ratio conversion map.
  • Example 2-2 In this example, the case where the mixture distribution of the above parameter set is expanded into multiple variables will be described.
  • the distribution functions f (x, y) and g (x, x, calculated using the tilt angle of the subject's posture state as multiple variables in the vertical direction (pitch angle) x and the horizontal direction (roll angle) y are used.
  • the mixing ratio of each parameter set is determined according to the value of the inclination angle (x, y). Therefore, the parameter set estimation unit 210 determines a more realistic mixing ratio from the tilt angle (x, y) specified based on the posture state signal detected by the motion sensor 14, for example, and determines the determined mixing ratio. Since the optimum parameter set is estimated or calculated by using the method, more accurate SpO2 can be calculated regardless of the posture state of the subject.
  • Modeling of the nonlinear mixture ratio conversion map is also realized by using nonlinear functions based on various n-th order polynomials instead of the above mixture distribution function.
  • f (x) is represented by the following non-linear function.
  • f (x) is It may be.
  • SpO2 is based on the absorptivity ratio (R) calculated based on the detected biological signal and the parameter set ( ⁇ 1 , ⁇ 1 ) corresponding to the posture state estimated according to the posture state signal.
  • R absorptivity ratio
  • a biological information measuring instrument for estimating a parameter set ( ⁇ 2 , ⁇ 2 ) when changing to another posture state in a short period of time and a measuring method using the same will be described. That is, the present embodiment utilizes the characteristic that the SpO2 value does not change or changes very little immediately before and after the change in the posture state of the subject.
  • FIG. 7 is a block diagram showing an example of the configuration of the biological information measuring instrument according to the embodiment of the present invention.
  • the biological information measuring instrument 1 according to the present embodiment is configured so that the parameter set estimation unit 210 can newly estimate the parameter set based on the SpO2 calculated by the SpO2 calculation unit 208. It is different from the embodiment.
  • the functions and / or configurations of the other components in the figure are the same as those described above, and thus the description thereof will be omitted.
  • the parameter set storage unit 206 stores, for example, the sitting parameter set ( ⁇ Sitting , ⁇ Sitting ).
  • the parameter set estimation unit 210 estimates a new parameter set based on the above-mentioned sitting parameter set, SpO2 value, and absorbance ratio, and further based on the absorbance ratio calculated in the immediately preceding posture state. Is also good.
  • the parameter set estimation unit 210 may be configured to receive the absorbance ratio and the attitude state in time series from the absorbance ratio calculation unit 204 and the attitude state estimation unit 205, respectively.
  • the parameter set estimation unit 210 stores the newly estimated parameter set as a reclining parameter set in the parameter set storage unit 206.
  • the posture state of the subject changes to a state other than these during the measurement of SpO2. Even so, it is possible to estimate the parameter set and add the estimated new parameter set to the parameter set storage unit 206 at any time so that the parameter sets in various posture states can be accumulated. Become.
  • ⁇ is a function according to the posture state and the absorbance ratio R.
  • the biological information measuring device 1 shown in the figure is the above-described embodiment in that the parameter set selection unit 207 receives the posture state estimated from the posture state estimation unit 205 and also receives the absorbance ratio from the absorbance ratio calculation unit 204. It is different from the configuration in.
  • the parameter set selection unit 207 is the lying state corresponding to the lying state and the absorbance ratio.
  • a parameter set ( ⁇ fix , ⁇ fix , ⁇ Lying ) including the position parameter ⁇ Lying is selected, and this is output to the SpO2 calculation unit 208.
  • the parameter set selection unit 207 selects the recumbent position parameter ⁇ Lying corresponding to the recumbent state and the absorbance ratio, and combines this with the fixed parameter set ( ⁇ fix , ⁇ fix ) to create a new parameter set ( ⁇ fix). , ⁇ fix , ⁇ Lying ).
  • the SpO2 calculation unit 208 of the present embodiment calculates SpO2 using the following formula.
  • SpO2 ⁇ fix + ⁇ fix ⁇ R + ⁇ ... Equation 19
  • the SpO2 calculation unit 208 calculates SpO2 according to the above formula based on the absorbance ratio (R) based on the detected biological signal and the selected parameter set ( ⁇ fix , ⁇ fix , ⁇ Lying ).
  • the biological information measuring device 1 may be configured by the parameter set estimation unit 210 instead of the parameter set selection unit 207. That is, the parameter set estimation unit 210 selects one or two or more parameters ⁇ according to the estimated posture state, estimates the optimum parameter ⁇ from these parameters ⁇ , and sets a parameter set based on the parameter ⁇ ( ⁇ fix , ⁇ fix , ⁇ ) may be output to SpO2.
  • the vessel and the measurement method using the vessel will be described.
  • the parameter set estimation unit 210 detects, for example, the SpO2 value calculated when the posture state stored in the measurement result storage unit 209 is the recumbent state, the fixed parameter set ( ⁇ fix , ⁇ fix ), and the detection. Based on the absorbance ratio (R) calculated based on the obtained biological signal, the parameter ⁇ when the posture state is the sitting state is estimated.
  • the posture state is estimated by using the biological signal obtained from the biological sensor 12 in addition to the posture state signal obtained from the motion sensor 14, and the optimum parameter set corresponding to the estimated posture state is selected.
  • a biological information measuring device to be estimated and a measuring method using the same will be described.
  • the biological signal receiving unit 202 receives the biological signal output from the biological sensor 12, it outputs it to the absorbance ratio calculation unit 204 and the posture state estimation unit 205, respectively. Further, when the posture state signal receiving unit 203 receives the posture state signal output from the motion sensor 14, the posture state signal receiving unit 203 outputs the posture state signal to each of the posture state estimation units 205. From this, the posture state estimation unit 205 estimates the posture state of the subject based on the biological signal and the posture state signal.
  • the posture state of the subject can generally be estimated using the posture state signal obtained by the motion sensor 14, but when comparing the standing position and the sitting position, for example, which of the posture state signals obtained from the inertial sensor is used alone. It is difficult to estimate whether it is in a postural state.
  • the present inventors have confirmed that the biological signal detected by the biological sensor 12 differs depending on the posture state of the subject. Therefore, for example, the posture state estimation unit 205 provisionally estimates the posture state of the subject based on the posture state signal, and finally estimates the posture state based on the biological signal for the provisionally estimated posture state. It is configured to do.
  • the posture state estimation unit 205 estimates the posture state by using the biological signal obtained from the biological sensor 12 in addition to the posture state signal obtained from the motion sensor 14. , A more accurate posture state will be obtained, and therefore the parameter set selected will also be more accurate.
  • the parameter set ( ⁇ , ⁇ , ⁇ ) including the parameters ⁇ , ⁇ , and ⁇ has been described, but the present invention is not limited to these parameters.
  • a parameter set including parameters considering such noise may be used.
  • steps, operations or functions may be performed in parallel or in a different order as long as the results are not inconsistent.
  • the steps, actions and functions described are provided by way of example only, and some of the steps, actions and functions can be omitted and combined with each other to the extent that they do not deviate from the gist of the invention. It may be one, or other steps, actions or functions may be added.
  • Biometric information measuring device 10 ... Sensor unit 12 ... Biological sensor 12a ... PPG sensor 14 ... Motion sensor 14a ... Inertial sensor 14b ... Geomagnetic sensor 20 ... Control unit 201 ... Sensor control unit 202 ... Biometric signal receiving unit 203 ... Attitude state signal Reception unit 204 ... Absorption ratio calculation unit 205 ... Attitude state estimation unit 206 ... Parameter set storage unit 207 ... Parameter set selection unit 208 ... SpO2 calculation unit 209 ... Measurement result storage unit 210 ... Parameter set estimation unit 30 ... User interface unit 40 ... Communication interface section

Abstract

La présente invention concerne un dispositif de mesure d'informations biologiques comprenant : une unité d'acquisition de signal biologique qui acquiert un signal biologique d'un sujet, qui est émis à partir d'un biocapteur comprenant un capteur PPG ; une unité d'acquisition de signal d'état de posture qui acquiert un signal d'état de posture du sujet, qui est émis par un capteur de mouvement ; une unité d'estimation d'état de posture qui estime un état de posture du sujet sur la base du signal d'état de posture acquis par l'unité d'acquisition de signal d'état de posture ; et une unité de calcul de SpO2 qui calcule le SpO2 du sujet au moment où il se trouve dans un état de posture de référence sur la base du signal biologique acquis par l'unité d'acquisition de signal biologique et de l'état de posture estimé par l'unité d'estimation d'état de posture. L'unité de calcul de SpO2 calcule le SpO2 par application, à un rapport d'absorbance calculé sur la base du signal biologique acquis, d'un ensemble de paramètres prescrits en fonction de l'état de posture estimé.
PCT/JP2020/009443 2019-04-04 2020-03-05 Dispositif de mesure d'informations biologiques et procédé de mesure d'informations biologiques l'utilisant WO2020203020A1 (fr)

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WO2022211272A1 (fr) * 2021-03-31 2022-10-06 삼성전자 주식회사 Dispositif électronique permettant de mesurer la tension artérielle sur la base de la posture de l'utilisateur et son procédé de commande

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JPH07100127A (ja) * 1993-10-08 1995-04-18 Chiesuto M I Kk 酸素飽和度測定記録装置
JP2001321361A (ja) * 2000-05-18 2001-11-20 Nippon Koden Corp 生理機能検査装置および生理機能検査結果表示装置
JP2005253865A (ja) * 2004-03-15 2005-09-22 Seiko Epson Corp 生体評価装置、生体評価方法、生体評価プログラム及び記録媒体
JP2006026092A (ja) * 2004-07-15 2006-02-02 Matsushita Electric Ind Co Ltd 加速度情報送信装置、身体運動解析装置および身体運動解析方法

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Publication number Priority date Publication date Assignee Title
JPH07100127A (ja) * 1993-10-08 1995-04-18 Chiesuto M I Kk 酸素飽和度測定記録装置
JP2001321361A (ja) * 2000-05-18 2001-11-20 Nippon Koden Corp 生理機能検査装置および生理機能検査結果表示装置
JP2005253865A (ja) * 2004-03-15 2005-09-22 Seiko Epson Corp 生体評価装置、生体評価方法、生体評価プログラム及び記録媒体
JP2006026092A (ja) * 2004-07-15 2006-02-02 Matsushita Electric Ind Co Ltd 加速度情報送信装置、身体運動解析装置および身体運動解析方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022211272A1 (fr) * 2021-03-31 2022-10-06 삼성전자 주식회사 Dispositif électronique permettant de mesurer la tension artérielle sur la base de la posture de l'utilisateur et son procédé de commande

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