WO2020168864A1 - 磁微粒化学发光免疫分析仪暗箱检测系统 - Google Patents

磁微粒化学发光免疫分析仪暗箱检测系统 Download PDF

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Publication number
WO2020168864A1
WO2020168864A1 PCT/CN2020/072124 CN2020072124W WO2020168864A1 WO 2020168864 A1 WO2020168864 A1 WO 2020168864A1 CN 2020072124 W CN2020072124 W CN 2020072124W WO 2020168864 A1 WO2020168864 A1 WO 2020168864A1
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WIPO (PCT)
Prior art keywords
cup
cup holder
reaction cup
dark
detection
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PCT/CN2020/072124
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English (en)
French (fr)
Inventor
胡晓雷
熊知灵
Original Assignee
重庆科斯迈生物科技有限公司
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Priority to EP20760214.5A priority Critical patent/EP3929591A4/en
Publication of WO2020168864A1 publication Critical patent/WO2020168864A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/13—Moving of cuvettes or solid samples to or from the investigating station
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/13—Moving of cuvettes or solid samples to or from the investigating station
    • G01N2021/135—Sample holder displaceable
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the invention relates to the field of medical detection equipment, in particular to a black box detection system of a magnetic particle chemiluminescence immune analyzer.
  • Chemiluminescence immunoassay is mainly a means of detection using the specific reaction of antigen and antibody. Because it can amplify and display the detection signal by using isotopes, enzymes, chemiluminescent substances, etc., the antigen or antibody Linked with a certain enzyme to form an enzyme-labeled antigen or antibody, this enzyme-labeled antigen or antibody retains its immune activity and enzyme activity, and then adds luminescent substrate after washing.
  • the test solution is usually in the reaction cup When the luminescent substrate is added, the reaction cup is sent to the detection dark box for detection.
  • the luminescence immunoassay of the detection solution is realized by detecting the amount of luminescence of the substance in the reaction cup in the detection dark box.
  • the existing detection system usually The gripper is used to seal the detection dark box.
  • the gripper carries a negative pressure suction cup and puts it in the test In the dark box, the gripper is also used for airtight shading.
  • the negative pressure of the gripper will easily lead to the inhalation of reagents, which affects the reliability of the gripper, or the negative pressure causes the substrate filling amount to be inaccurate , Affecting the accuracy of the test results.
  • the present invention provides a magnetic particle chemiluminescence immunoassay black box detection system, which helps to improve the reliability of the gripper, while ensuring the accuracy of substrate filling and the accuracy of the detection result.
  • a black-box detection system of magnetic particle chemiluminescence immunoassay analyzer the key of which is to include:
  • the detection dark box is arranged on the base plate and is provided with a dark room inside, and one side of the dark room is provided with an entrance and exit;
  • the reaction cup holder is arranged on the substrate and has a cup holding groove for placing the reaction cup.
  • the reaction cup holder can slide relative to the detection dark box to open or close the entrance and exit.
  • the reaction cup holder has detection and placement in its sliding stroke. Cup position. When the reaction cup holder is in the detection position, the cup holder is in the dark room and the inlet and outlet are closed. When the reaction cup holder is in the cup position, the cup holder is outside the dark room and the inlet and outlet are open;
  • the detection mechanism is used to detect the luminous quantity of the liquid in the reaction cup in the dark room;
  • the transfer device is used to put the reaction cup into the cup holder or remove the reaction cup from the cup holder.
  • the darkroom adopts a door opening structure relatively independent of the gripper.
  • the reaction cup in the darkroom in this scheme will not be affected by the negative pressure of the gripper, and the suction nozzle of the gripper will not be affected.
  • the filling of the corresponding substrate will not be affected by negative pressure, ensuring the accuracy of the filling amount of the substrate, which is beneficial to improve the reliability of the detection result and the gripping action.
  • the driving mechanism includes a screw motor, the screw motor is located on one side of the detection dark box, and the extension direction of the screw is consistent with the sliding direction of the cuvette holder, and the cuvette holder is threadedly matched with the screw.
  • the screw motor is located on one side of the detection dark box, and the extension direction of the screw is consistent with the sliding direction of the cuvette holder, and the cuvette holder is threadedly matched with the screw.
  • a cup holder rail parallel to the screw rod is fixed below the screw rod, and the cup holder guide rail is provided with a cup holder slider that is slidably fitted therewith, and the reaction cup holder is fixedly connected to the cup holder slider.
  • Adopting the above scheme is beneficial to ensure the stability of the reaction cup holder when it moves, and at the same time ensure the accuracy of each position of the cup holder and the reliability of the entrance and exit.
  • a motor reset sensor is provided above one end of the screw rod close to the motor of the screw rod, and a trigger sheet adapted to the motor reset sensor is provided on the reaction cup holder.
  • the trigger piece and the motor reset sensor cooperate to ensure the stability of the cup holder slot in the detection position, ensure that the initial position of the screw motor is consistent every time it runs, and avoid large position errors that cause the cup to be placed. Or failure to grab the cup occurs.
  • the reaction cup holder also has a cup dropping position within its sliding stroke, and one side of the cup holding groove is open to form a cup dropping mouth
  • the transfer device includes a push arm movably arranged on the substrate, so The pushing arm can move in the direction of the cup dropping mouth.
  • the pushing arm movement can push the reaction cup in the cup holding groove out of the cup dropping mouth.
  • the transfer device further includes a gripping mechanism
  • the gripping mechanism includes a support beam and a suction nozzle
  • the support beam is provided with an X-direction drive assembly for driving the suction nozzle to move horizontally along its length
  • the support beam is located on the side facing the entrance and exit, and the support beam and the screw rod are perpendicular to each other.
  • the X-direction drive assembly includes an X-direction slide rail arranged along the length of the support beam, and an X-direction drive motor located at one end of the support beam.
  • the X-direction slide rail has an X-direction first sliding block slidingly fitted to the X-direction sliding rail, and the X-direction first sliding block has a vertical plate fixedly connected to it;
  • the Z-direction drive assembly includes a Z-direction slide rail arranged along the height direction of the vertical plate, and the Z-direction slide rail is provided with a Z-direction sliding block slidingly matched with the Z-direction slide rail.
  • a Z-direction drive motor that slides toward the slide rail, and the suction nozzle is fixedly connected with the Z-direction slider.
  • the push arm is slidably fitted with the X-direction sliding rail through the X-direction second sliding block
  • the vertical plate is provided with a metal piece
  • the push arm has an upper magnet arranged opposite to the metal piece.
  • the block is driven by the X-direction drive motor to approach the X-direction second sliding block
  • the metal piece and the upper magnet are attracted to each other to drive the push arm to slide along the X-direction slide rail.
  • the magnetic mutual attraction method is adopted to realize the linkage between the vertical plate and the push arm, that is, the push arm can be moved through the X-direction drive assembly to complete the cup dropping operation.
  • the X-direction slide rail is provided with a front limit structure and a rear limit structure on the front and rear sides of the push arm, respectively, and the push arm has a lower magnet arranged directly opposite the front limit structure.
  • the limit structure on the front and rear sides is used to limit the sliding stroke of the push arm.
  • the rear position structure is used to realize the separation of the push arm from the vertical plate and the fixed state relative to the support beam to prevent the push arm from sliding or sliding together with it. Shaking, causing interference to other parts.
  • the detection camera is provided with an outwardly extending baffle at the corresponding entrance and exit, the baffle is located on the side directly opposite to the mouth of the cup, and when the cuvette holder is in the cup placement position, the baffle is located on the cup.
  • the reaction cup holder is provided with a relief hole at the position facing the baffle.
  • the magnetic particle chemiluminescence immunoassay black box detection system adopting the above technical scheme mainly adopts an open door detection black box structure relatively independent of the gripper, effectively avoiding the mutual interference between the substrate filling and the negative pressure suction nozzle of the gripper. Improve the reliability of gripping actions and detection results.
  • Figure 1 is a schematic diagram of the structure of the present invention
  • Figure 2 is a schematic diagram of the installation structure of the reaction cup holder
  • Figure 3 is a schematic diagram of the internal structure of the detection dark box when the cup holder is in the detection position
  • Figure 4 is a schematic diagram of the structure of the detection dark box
  • Figure 5 is a schematic diagram of the structure of the reaction cup holder
  • Figure 6 is a schematic diagram of the matching structure of the detection dark box and the reaction cup holder
  • Figure 7 is a schematic structural diagram of the cup-holding groove in the detection position
  • Figure 8 is a schematic structural view of the cup-holding groove in the cup-holding position
  • Figure 9 is a schematic structural diagram of the cup-holding groove in the cup-losing position
  • Figure 10 is a schematic diagram of the structure of the gripping mechanism
  • Figure 11 is a schematic diagram of the installation structure of the push arm
  • Figure 12 is a schematic diagram of the push arm structure
  • Fig. 13 is a side view of Fig. 12.
  • the magnetic particle chemiluminescence immunoassay dark box detection system of the present invention mainly includes a rectangular plate-shaped substrate 6 (for ease of understanding and text introduction, the length direction of the substrate 6 is defined in this embodiment It is the X direction, the width direction is the Y direction, and the thickness direction is the Z direction, as shown in Figure 1), one end of the substrate 6 is provided with a cuvette placement area 60, and the other end is provided with a detection dark box 1, which is provided with In the hollow darkroom 10, one side of the darkroom 10 is provided with an inlet and outlet 11 communicating with its inner cavity.
  • the orientation of the inlet and outlet 11 is consistent with the Y direction, and a reaction cup is provided on the substrate 6 at a position facing the inlet and outlet 11
  • the seat 2 is equipped with a driving mechanism 3 for driving the reaction cup holder 2 to move.
  • the reaction cup holder 2 can slide relative to the detection dark box 1 under the action of the driving mechanism 3, and has two positions of detection and cup placement on its sliding stroke
  • the reaction cup holder 2 is provided with a cup holding groove 20 for placing the reaction cup, and the top of the cup holding groove 20 is open.
  • the top of the detection dark box 1 is provided with a substrate filling connector 15 which communicates with the dark chamber 10, and the substrate liquid can be filled through the substrate filling connector 15.
  • the outer wall of the detection camera 1 is provided with a ring-shaped seal ring 13 at a position corresponding to the inlet and outlet 11.
  • the seal ring 13 protrudes vertically from the surface of the detection camera 1 and is located at the inlet and outlet 11.
  • the reaction cup holder 2 is provided with a matching sealing groove 24 at the position facing the sealing ring 13.
  • the side of the detection dark box 1 away from the cuvette placement area 60 is provided with a detection mechanism 4, the detection mechanism 4 is mainly used to detect the amount of luminescence of the solution in the cuvette in the dark room 10, the driving mechanism 3 is in and On the opposite side of the mechanism 4, the side of the detection dark box 1 close to the cuvette placement area 60 has a mounting plate 14 integrally formed therewith, and the mounting plate 14 is L-shaped.
  • the driving mechanism 3 includes a screw motor 30.
  • the screw motor 30 is arranged along the Y direction and is fixedly supported on the mounting plate 14.
  • the extension direction of the screw 300 of the screw motor 30 is consistent with the direction of the inlet and outlet 11 .
  • the bottom of the mounting plate 14 corresponding to the screw 300 is provided with a cup holder guide rail 31, the cup holder guide rail 31 is arranged along the Y direction, there is a cup holder slider 32 slidingly fitted thereon, the reaction cup holder 2 is fixedly supported on the cup holder
  • the slider 32 is also threaded with the screw rod 300 above.
  • the screw rod 300 can drive the reaction cup holder 2 to slide along the cup holder guide rail 31, and make the reaction cup holder 2 stay in the detection Position or cup position.
  • a motor reset sensor 33 is provided above the screw 300 in this embodiment. As shown in the figure, the motor reset sensor 33 is fixed at It is detected on the dark box 1 and close to the root position of the screw 300.
  • the reaction cup holder 2 has a trigger sheet 21 adapted to the motor reset sensor 33. When the reaction cup holder 2 is driven by the screw 300 to move toward the root of the screw 300, When the reaction cup holder 2 is in the detection position, the trigger sheet 21 just triggers the reset sensor 33, and the reset sensor 33 can send a reset signal to the central control of the instrument, and then continue the next step. Otherwise, it indicates that the reaction cup holder 2 is not in place.
  • the reaction cup holder 2 is driven by the driving mechanism 3 to make the reaction cup holder 2 reach the cup dropping position shown in Figure 9.
  • the cup dropping position is farther away from the inlet and outlet 11 than the cup placing position.
  • the cup holder 20 is open at the side of the cuvette placement area 60 to form a cup holder 22.
  • the reaction cup located in the cup holder 20 can be opened from the top It can also be moved in and out horizontally from the cup dropping port 22 for putting in or out.
  • the cup dropping port 22 in this embodiment is mainly used to remove the reaction cup from the cup holding groove 20.
  • the substrate 6 is provided with A transfer device that puts the reaction cup into the cup holding groove 20 and removes the reaction cup in the cup holding groove 20.
  • the transfer device in this application mainly includes a gripper mechanism 5 and a push arm 7, wherein the gripper mechanism 5 mainly includes a support beam 51 and a suction nozzle 52, wherein the support beam 51 is arranged along the X direction, and the screw rod
  • the installation directions of 300 are perpendicular to each other, and are located on the side directly opposite to the inlet and outlet 11.
  • the supporting beam 51 is provided with an X-direction drive assembly and a Z-direction drive assembly to drive the suction nozzle 52 to move along the X direction or the Z direction.
  • the X-direction drive assembly specifically includes an X-direction slide rail 5a arranged along the length direction of the support beam 51, the X-direction slide rail 5a has an X-direction first sliding block 5c that is slidably engaged with it, and the X-direction first slide block 5c has a fixed
  • the vertical plates 53 are connected to each other.
  • the vertical plates 53 have a rectangular plate structure and are arranged along the Z direction.
  • One end of the support beam 51 is provided with an X-direction drive motor 5b.
  • the X-direction drive motor 5b drives the X through a synchronous belt transmission mechanism.
  • the first sliding block 5c slides along the X-direction slide rail 5a, wherein the timing belt in the timing belt transmission mechanism is fixedly connected with the vertical plate 53.
  • the Z-direction drive assembly specifically includes a Z-direction slide rail 5d arranged along the height direction of the vertical plate 53, the Z-direction slide rail 5d is fixed on the vertical plate 53, and at the same time has a Z-direction sliding block 5e slidingly matched with the vertical plate 53.
  • the end is provided with a Z-direction drive motor 5f.
  • the Z-direction drive motor 5f is also a screw nut motor, which drives the screw rod vertically downward and is threaded with the Z-direction slider 5e.
  • the suction nozzle 52 and Z The sliding block 5e is supposed to be fixedly connected, so that when the Z-direction drive motor 5f works, the suction nozzle 52 can be driven to move up and down in the Z-direction.
  • the push arm 7 in this embodiment is movably arranged on the X-direction slide rail 5a through the X-direction second slider 5g. As shown in the figure, the push arm 7 can slide along the X-direction through the X-direction second slider 5g. 5a slides in the X direction.
  • the push arm 7 mainly includes a push arm seat 71 and a push arm rod 72.
  • the push arm seat 71 is fixedly connected to the X-direction second sliding block 5g, and the push arm rod 72 is fixedly connected to the push arm seat 71.
  • the push arm seat 71, the push arm rod 72, and the suction nozzle 52 have a certain position offset in the Y direction, wherein the vertical distance between the push arm rod 72 and the suction nozzle 52 in the Y direction and the cup position and drop The distance between the cup positions is adapted.
  • the push arm rod 72 extends vertically downward, and its lower end has a toggle head 720.
  • the upper end of the side wall of the cup holding groove 20 opposite to the cup drop opening 22 is provided with a U-shaped passage opening 25.
  • the passage opening 25 The size is compatible with the toggle head 720, and the through port 25 is located on the sliding path of the toggle head 720, so that when the cuvette holder 2 is in the cup dropping position, the push arm 7 slides in the X direction, and the toggle head 720 can It enters into the cup-holding groove 20 through the passage opening 25, thereby pushing the reaction cup out of the cup drop opening 22, a recovery hole is provided at the corresponding position on the substrate 6, and the pushed reaction cup falls from the recovery hole and is recovered and processed.
  • the sliding of the push arm 7 in the present application is completed by the X-direction drive assembly of the gripper.
  • the push arm seat 71 is provided with one on the side close to the suction nozzle 52.
  • the magnets are respectively the upper magnet 73 and the lower magnet 70.
  • the vertical plate 53 is provided with a metal piece 530 at a position opposite to the upper magnet 73. When the vertical plate 53 slides with the X toward the first slider 5c and approaches the push arm 7, the metal The piece 530 and the upper magnet 73 are attracted to each other, which can drive the push arm 7 to slide in the X direction to complete the cup dropping and resetting actions.
  • the X-direction slide rail 5a is provided with a front limit structure 54 and a rear limit in this embodiment.
  • the position structure 55, the front limit structure 54 and the rear limit structure 55 correspond to the position of the cup holder 20 in the X direction, which is slightly wider than the cup holder 20.
  • the distance between the front limit structure 54 and the rear limit structure 55 constitutes The sliding section of the push arm 7 is shown in the figure.
  • the rear limit structure 55 is provided with a limit screw. The limit screw is located at the end of the X-direction slide rail 5a and protrudes outward.
  • the front limit structure 54 It is a limit block set on the support beam 51, but the existence of the limit block does not hinder the sliding of the vertical plate 53 in the X direction, and the limit block is also made of metal flux magnetic material and is aligned with the lower magnet 70
  • the suction nozzle 52 moves from the cuvette placement area 60 to the end of the detection dark box 1
  • the metal piece 530 and the upper magnet 73 attract each other, and the push arm 7 can be driven to slide together, and
  • X slides in the opposite direction to the first slider 5c that is, slides from the end where the detection dark box 1 is located toward the cuvette placement area 60.
  • the lower magnet 70 and the limit block abut and contact each other
  • the upper magnet 73 and the metal piece 530 are separated from each other, and the suction nozzle 52 continues to move, and because the lower magnet 70 and the stop block are attracted to each other, the push arm 7 will not sway relative to the support beam 51 , To ensure that the push arm 7 stays in the reset position and will not interfere with other components below.
  • the detection camera 1 is provided with a baffle 12 at the position corresponding to the inlet and outlet 11, as shown in the figure, the baffle 12 is located on the side directly opposite to the cup opening 22, and is located above the inlet and outlet 11.
  • the baffle 12 extends outward along the Y direction, and its extension length is adapted to the cup placement position of the cuvette holder 2, that is, when the cuvette holder 2 is in the cup placement position, the baffle 12 is just in front of the cup drop opening 22 , And close to the side wall of the cup-holding groove 20 to prevent the reaction cup placed in the cup-holding groove 20 from falling out of the cup opening 22 during the movement, which affects the detection efficiency.
  • the sliding of the cuvette holder 2 causes interference, so the cuvette holder 2 is provided with a relief hole 23 at a position directly opposite to the baffle 12.
  • the baffle 12 can just be inserted In the relief hole 23, because the baffle plate 12 is located inside the sealing ring 13, the sealing performance of the inlet and outlet 11 will not be affected.
  • the detection mechanism 4 of the present application mainly includes a light guide rod 40, a photoelectric tube 41, and a light control component 42, wherein the light guide rod 40 is located in the detection dark box 1, and one end of the light guide rod 40 is directly connected to the dark room 10, and When the cuvette holder 2 is in the detection position, this end is directly facing the lower part of the dropping cup opening 22, and is used to guide the luminosity of the liquid in the cuvette in the cup holding groove 20 to the photocell 41, and the other end is facing the photocell 41
  • the light control component 42 mainly includes a light control plate 420 arranged between the light guide rod 40 and the photoelectric tube 41, and a light control drive motor 421 that drives the light control plate 420 to rotate horizontally.
  • the light drive motor 421 drives the light control plate
  • the rotation of 420 can realize the on-off of the light path between the light guide rod 40 and the photoelectric tube 41, achieve a better light control effect, avoid damage to the photoelectric tube 41, and prolong its service life
  • the reaction cup placement area 60 is mainly used to place the reaction cup 8.
  • the reaction cup holder 2 is in the cup placement position, and the suction nozzle 52 is lowered and placed from the reaction cup under negative pressure.
  • the zone 60 sucks the reaction cup 8, and then slides in the X direction to the top of the cup holding groove 20, and then the suction nozzle 52 descends, and the reaction cup 8 is put into the cup holding groove 20.
  • the screw motor 30 is reset to move the reaction cup holder 2 from the cup placement position to the detection position.
  • the reaction cup 8 is brought into the dark room 10, and at the same time, the inlet and outlet 11 are sealed, and then the substrate filling connector 15 faces The substrate liquid is added to the reaction cup 8, and then the liquid luminescence detection is completed by the detection mechanism 4.
  • the screw motor 30 works to move the reaction cup holder 2 from the detection position to the cup dropping position, and the X-direction drive motor 5b works to make the vertical plate 53 close to the push arm 7 and drive the push arm 7 to move away from the reaction cup.

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Abstract

一种磁微粒化学发光免疫分析仪暗箱检测系统，包括：基板(6)；设置于基板(6)上的检测暗箱(1)；检测暗箱(1)的内部设有一侧开口的暗室(10)；反应杯座(2)具有用于放置反应杯的置杯槽(20)，并可相对检测暗箱(1)滑动以打开或封闭进出口(11)；反应杯座(2)在滑动行程内具有检测和放杯位置；当反应杯座(2)位于检测位置时，置杯槽(20)处于暗室(10)内，进出口(11)封闭；当反应杯座(2)位于放杯位置时，置杯槽(20)处于暗室(10)外，进出口(11)打开；驱动机构(3)，用于驱动反应杯座(2)滑动；检测机构(4)，用于检测暗室(10)中反应杯内液体的发光量；移送装置，用于将反应杯放入置杯槽(20)或将置杯槽(20)的反应杯移出。采取与抓手相对独立的开门式检测暗箱结构，有效避免底物加注与抓手负压吸嘴之间的相互干扰，从而提高抓手动作及检测结果的可靠性。

Description

磁微粒化学发光免疫分析仪暗箱检测系统 技术领域
本发明涉及医学检测设备领域，具体涉及一种磁微粒化学发光免疫分析仪暗箱检测系统。
背景技术
化学发光免疫检测主要是利用抗原和抗体的特异性反应进行检测的一种手段，由于其能够利用同位素、酶、化学发光物质等对检测信号进行放大和显示，在进行实验时，使抗原或抗体与某种酶连接成酶标抗原或抗体，这种酶标抗原或抗体既保留其免疫活性，又保留酶的活性，然后洗涤后加入发光底物，在实验室中，通常检测液在反应杯内进行检测，当加入发光底物之后，将反应杯送入检测暗箱中检测，通过检测反应杯内物质在检测暗箱内的发光量，从而实现检测液的发光免疫检测，现有检测系统中通常采用抓手对检测暗箱进行密闭的方式，如在专利号为“CN201721086253.0”，专利名称为“化学发光免疫分析暗箱高效检测装置”的专利中，抓手进行负压吸杯，放入检测暗箱中，同时依靠抓手进行密闭遮光，然而因为底物加注口的存在，容易导致抓手的负压习惯吸入试剂，影响抓手可靠性，或因为负压导致底物加注量不准确，影响检测结果的准确性。
发明内容
有鉴于此，本发明提供了一种磁微粒化学发光免疫分析仪暗箱检测系统，有助于提高抓手可靠性，同时确保底物加注精准，保证检测结果的准确性。
其技术方案如下：
一种磁微粒化学发光免疫分析仪暗箱检测系统，其关键在于，包括：
基板；
检测暗箱，其设置于基板上，内部设有暗室，所述暗室的一侧开设有进出口；
反应杯座，其设置于基板上，具有用于放置反应杯的置杯槽，所述反应杯座可相对检测暗箱滑动以打开或封闭进出口，反应杯座在其滑动行程内具有检测和放杯位置，当反应杯座位于检测位置时，置杯槽处于暗室内，进出口封闭，当反应杯座位于放杯位置时，置杯槽处于暗室外，进出口打开；
驱动机构，用于驱动反应杯座滑动；
检测机构，用于检测暗室中反应杯内液体的发光量；
移送装置，用于将反应杯放入置杯槽或将置杯槽的反应杯移出。
采用以上方案，暗室采取与抓手相对独立的开门结构，相对现有结构而言，本方案中处于暗室内的反应杯不会受到抓手负压影响，抓手负压吸嘴也不会受到液体影响，相应底物加注也不会受到负压影响，确保底物加注量的准确性，有利于提高检测结果及抓手动作的可靠性。
作为优选：所述驱动机构包括丝杆电机，所述丝杆电机位于检测暗箱的一侧，其丝杆延伸方向与反应杯座的滑动方向一致，所述反应杯座与丝杆螺纹配合。采用以上方案，通过丝杆电机实现反应杯座的移动及位置停留，结果简单，便于实施。
作为优选：所述丝杆下方固设有与其平行的杯座导轨，所述杯座导轨上具有与其滑动配合的杯座滑块，所述反应杯座与杯座滑块固定连接。采用以上方案，有利于保证反应杯座移动时的稳定性，同时确保置杯槽在各位置的准确性，以及通过进出口的可靠性。
作为优选：所述丝杆靠近丝杆电机一端的上方设有电机复位传感器，所述反应杯座上设有与电机复位传感器适配的触发片。采用以上方案，通过触发片与电机复位传感器配合，有利于保证置杯槽处于检测位置时的稳定性， 确保丝杆电机每次运转时初始位置一致，避免出现较大的位置误差，导致放杯或抓杯失败的情况发生。
作为优选：所述反应杯座在其滑动行程内还具有丢杯位置，且所述置杯槽的一侧敞口形成丢杯口，所述移送装置包括活动设置于基板上的推臂，所述推臂可沿丢杯口的朝向移动，反应杯座处于丢杯位置时，所述推臂移动可将置杯槽内的反应杯从丢杯口处推出。采用以上方案，通过推臂直接将反应杯从丢杯口处推出，减少抓手动作程序，提高弃杯效率。
作为优选：所述移送装置还包括抓手机构，所述抓手机构包括支撑梁和吸嘴，所述支撑梁上设有用于驱动吸嘴沿其长度方向水平移动的X向驱动组件，以及沿其高度方向运动的Z向驱动组件，所述支撑梁位于进出口正对的一侧，且支撑梁与丝杆相互垂直。采用以上方案，通过X向和Z向驱动组件实现吸嘴的水平和升降移动，满足检测过程中各工序需求。
为减少动力机构及传动机构部件，提高整体紧凑性，降低经济成本，所述X向驱动组件包括沿支撑梁长度方向设置的X向滑轨，以及位于支撑梁一端的X向驱动电机，所述X向滑轨具有与其滑动配合的X向第一滑块，所述X向第一滑块上具有与其固定连接的竖板；
所述Z向驱动组件包括沿竖板高度方向设置的Z向滑轨，所述Z向滑轨上具有与其滑动配合的Z向滑块，所述竖板上设有驱动Z向滑块沿Z向滑轨滑动的Z向驱动电机，所述吸嘴与Z向滑块固定连接。
作为优选：所述推臂通过X向第二滑块与X向滑轨滑动配合，所述竖板上具有金属件，推臂上具有正对金属件设置的上部磁铁，当X向第一滑块在X向驱动电机驱动下靠近X向第二滑块时，所述金属件与上部磁铁相互吸引以带动推臂沿X向滑轨滑动。采用磁力互吸方式，实现竖板与推臂的联动，即通过X向驱动组件即可实现推臂的动作，完成丢杯操作。
作为优选：所述X向滑轨上在推臂的前后两侧分别设有前限位结构和后限位结构，所述推臂具有正对前限位结构设置的下部磁铁。采用以上方案，通过前后两侧的限位结构实现对推臂滑动行程的限定，同时依靠后位结构实现推臂与竖板的分离以及相对支撑梁处于固定状态，避免推臂随其一起滑动或晃动，对其他部件造成干扰。
作为优选：所述检测暗箱对应进出口设有向外延伸的挡片，所述挡片位于丢杯口正对的一侧，当反应杯座处于放杯位置时，所述挡片位于丢杯口的正前方，所述反应杯座正对挡片的位置设有让位孔。采用以上方案，当往置杯槽内放入反应杯时，挡片刚好可将丢杯口挡住，可确保置杯槽内反应杯的稳定性，有效防止反应杯从丢杯口处掉出，提高结构可靠性。
与现有技术相比，本发明的有益效果：
采用以上技术方案的磁微粒化学发光免疫分析仪暗箱检测系统，主要采取与抓手相对独立的开门式检测暗箱结构，有效避免底物加注与抓手负压吸嘴之间的相互干扰，从而提高抓手动作及检测结果的可靠性。
附图说明
图1为本发明的结构示意图；
图2为反应杯座安装结构示意图；
图3为置杯槽处于检测位置时，检测暗箱的内部结构示意图；
图4为检测暗箱结构示意图；
图5为反应杯座结构示意图；
图6为检测暗箱与反应杯座配合结构示意图；
图7为置杯槽处于检测位置的结构示意图；
图8为置杯槽处于放杯位置的结构示意图；
图9为置杯槽处于丢杯位置的结构示意图；
图10为抓手机构结构示意图；
图11为推臂安装结构示意图；
图12为推臂结构示意图；
图13为图12的侧视图。
具体实施方式
以下结合实施例和附图对本发明作进一步说明。
参考图1至图13所示本发明的磁微粒化学发光免疫分析仪暗箱检测系统，其主要包括呈矩板状的基板6(为便于理解及文字简介，本实施例中定义基板6的长度方向为X向，宽度方向为Y向、厚度方向为Z向，如图1中所示)，基板6的一端设有反应杯放置区60，另一端设有检测暗箱1，检测暗箱1内设有中空的暗室10，暗室10的一侧设有与其内腔连通的进出口11，如图所示，进出口11的朝向与Y向一致，基板6上正对进出口11的位置设有反应杯座2，并配置有用于驱动反应杯座2移动的驱动机构3，反应杯座2在驱动机构3作用下可相对检测暗箱1发生滑动，并在其滑动行程上具有检测和放杯两个位置，同时反应杯座2上设有用于放置反应杯的置杯槽20，置杯槽20的顶部敞口。
参考图1和图3，检测暗箱1的顶部设有底物加注接头15，底物加注接头15与暗室10连通，通过底物加注接头15可进行底物液的加注。
参考图4至图6，检测暗箱1外壁上对应进出口11的位置设有呈环状结构的密封环13，密封环13自检测暗箱1的表面垂直向外凸起，且处于进出口11的周向外侧，反应杯座2上正对密封环13的位置设有与其配合的密封凹槽24，当反应杯座2处于检测位置时，置杯槽20刚好位于暗室10内，同时密封环13嵌入密封凹槽24内，反应杯座2与检测暗箱1正对的侧壁紧贴，从而实现暗室10的封闭避光，当反应杯座2处于放杯位置时，置杯槽20处于 暗室10外部，相应的密封环13从密封凹槽24内退出，进出口11处于打开状态。
参考图1至图5，检测暗箱1远离反应杯放置区60的一侧设有检测机构4，检测机构4主要用于检测处于暗室10内反应杯内溶液的发光量，驱动机构3处于与检测机构4相对的一侧，检测暗箱1上靠近反应杯放置区60的一侧具有与其一体成型的安装板14，安装板14呈L型。
驱动机构3包括丝杆电机30，如图所示，丝杆电机30沿Y向设置，其固定支撑于安装板14上，丝杆电机30的丝杆300延伸方向与进出口11的朝向保持一致，安装板14底部对应丝杆300的位置设有杯座导轨31，杯座导轨31沿Y向设置，其上具有与其滑动配合的杯座滑块32，反应杯座2则固定支撑于杯座滑块32上，同时与上方的丝杆300螺纹配合，当丝杆电机30工作时，通过丝杆300则可带动反应杯座2沿杯座导轨31滑动，并使反应杯座2停留在检测位置或放杯位置。
参考图2和图5，本实施例中，为确保反应杯座2停留位置准确，本实施例中在丝杆300的上方设有电机复位传感器33，如图所示电机复位传感器33固设于检测暗箱1上，且靠近丝杆300的根部位置，反应杯座2上具有与电机复位传感器33适配的触发片21，当反应杯座2在丝杆300带动下朝丝杆300根部移动，反应杯座2处于检测位置时，触发片21则刚好触发复位传感器33，复位传感器33则可向仪器中控发出复位信号，再继续下步工序，反之则表明反应杯座2未到位。
参考图1、图2、图5、图9和图10，本实施例中反应杯座2在驱动机构3的带动下，还可使反应杯座2达到图9中所示的丢杯位置，丢杯位置相对放杯位置更远离进出口11，同时置杯槽20远离反应杯放置区60的一侧敞口形成丢杯口22，位于置杯槽20内的反应杯可从顶部敞口处放入或放出，也可从 丢杯口22处水平移动进出，本实施例中的丢杯口22主要用于将反应杯从置杯槽20内移除，相应的，基板6上设有用于将反应杯放入置杯槽20内和将置杯槽20内的反应杯移除的移送装置。
如图所示，本申请中的移送装置主要包括抓手机构5和推臂7，其中抓手机构5又主要包括支撑梁51和吸嘴52，其中支撑梁51沿X向设置，与丝杆300的设置方向相互垂直，且位于进出口11正对的一侧，支撑梁51上配套设置有X向驱动组件和Z向驱动组件，以驱动吸嘴52沿X向或沿Z向移动，完成从反应杯放置区60内吸取反应杯，然后再送至置杯槽20的动作。
X向驱动组件具体包括沿支撑梁51长度方向设置的X向滑轨5a，X向滑轨5a上具有与其滑动配合的X向第一滑块5c，X向第一滑块5c上具有与其固定连接的竖板53，竖板53呈矩形板状结构，且沿Z向设置，支撑梁51的一端设有X向驱动电机5b，本实施例中X向驱动电机5b通过同步带传动机构带动X向第一滑块5c沿X向滑轨5a滑动，其中同步带传动机构中的同步带与竖板53固定连接。
Z向驱动组件具体包括沿竖板53高度方向设置的Z向滑轨5d，Z向滑轨5d固设于竖板53上，同时具有与其滑动配合的Z向滑块5e，竖板53的上端端部设有Z向驱动电机5f，本实施例中Z向驱动电机5f也为丝杆螺母电机，其驱动丝杆竖直朝下，并与Z向滑块5e螺纹配合，吸嘴52与Z想滑块5e固定连接，这样当Z向驱动电机5f工作时，即可带动吸嘴52做Z向升降移动。
本实施例中的推臂7通过X向第二滑块5g活动设有于X向滑轨5a上，如图所示，通过X向第二滑块5g，推臂7可沿X向滑轨5a进行X向的滑动，推臂7主要包括推臂座71和推臂杆72，其中推臂座71与X向第二滑块5g固定连接，推臂杆72再与推臂座71固定连接，且推臂座71、推臂杆72以及与吸嘴52相互之间Y向上具有一定位置偏移，其中推臂杆72与吸嘴52之间在 Y向的垂距与放杯位置和丢杯位置之间的距离相适应。
推臂杆72竖直向下延伸，其下端端部具有拨动头720，置杯槽20上与丢杯口22相对的一侧侧壁上端设有呈U形的通过口25，通过口25的大小与拨动头720相适应，且通过口25位于拨动头720的滑动路径上，这样当反应杯座2处于丢杯位置时，推臂7沿X向滑动，拨动头720则可以由通过口25进入置杯槽20中，从而将反应杯从丢杯口22处推出，基板6上对应位置设有回收孔，被推出的反应杯则从回收孔处掉落被回收处理。
为简化结构，降低制造成本，本申请中推臂7的滑动依靠抓手X向驱动组件完成，如图10至图13所示，推臂座71靠近吸嘴52的一侧上下各设有一个磁铁，分别为上部磁铁73和下部磁铁70，竖板53上正对上部磁铁73的位置设有金属件530，当竖板53随X向第一滑块5c滑动，靠近推臂7时，金属件530与上部磁铁73相互吸引，即可带动推臂7沿X向滑动，完成丢杯和复位的动作。
在此基础之上，为防止推臂7做不必要的滑动，导致推臂杆72对下方设备造成干扰，故本实施例中在X向滑轨5a上设有前限位结构54和后限位结构55，前限位结构54和后限位结构55对应置杯槽20在X方向的位置，比置杯槽20略宽，前限位结构54和后限位结构55之间的距离构成推臂7的滑动区间，如图所示，本实施例中后限位结构55为设置限位螺丝，限位螺丝位于X向滑轨5a的端部，并向外突出，前限位结构54为设置在支撑梁51上的限位块，但限位块的存在并不会妨碍竖板53沿X向的滑动，且限位块也为金属通磁材质制成，并与下部磁铁70正对设置，当吸嘴52从反应杯放置区60朝检测暗箱1所在一端移动，竖板53靠近推臂7之后，金属件530与上部磁铁73相互吸引，则可带动推臂7一同滑动，而当X向第一滑块5c反向滑动，即从检测暗箱1所在一端朝反应杯放置区60滑动，当滑动至前限位结构54的 位置时，下部磁铁70与限位块抵接并相互吸附，推臂7不能继续滑动，同时上部磁铁73与金属件530相互分离，吸嘴52继续移动，且因为下部磁铁70与限位块相互吸附，推臂7也不会相对支撑梁51发生晃动，确保推臂7停留在复位位置不会对下方其他部件产生干扰。
参考图4至图9，检测暗箱1上在对应进出口11的位置设有挡片12，如图所示，挡片12位于丢杯口22正对的一侧，且处于进出口11的上部，挡片12沿Y向向外延伸，其延伸长度与反应杯座2的放杯位置相适应，即当反应杯座2处于放杯位置时，挡片12刚好处于丢杯口22的正前方，并与置杯槽20的侧壁紧贴，以此防止放入置杯槽20的反应杯在移动过程中从丢杯口22处掉出，影响检测效率，相应的为防止挡片12对反应杯座2的滑动造成干涉，故反应杯座2上正对挡片12的位置设有让位孔23，当反应杯座2从放杯位置朝检测位置移动时，挡片12可刚好插入让位孔23内，因为挡片12处于密封环13的内侧，故也不会对进出口11的密封性造成影响。
参考图1至图3，本申请的检测机构4主要包括导光棒40、光电管41以及控光组件42，其中导光棒40位于检测暗箱1内，其一端正对与暗室10连通，且当反应杯座2处于检测位置时，该端端部正对丢杯口22的下部，用于将处于置杯槽20内反应杯内液体的光度引导至光电管41，另一端正对光电管41的感光端，控光组件42主要包括设置在包括导光棒40和光电管41之间的控光板420，以及驱动控光板420水平旋转的控光驱动电机421，光驱动电机421驱动控光板420转动可实现导光棒40和光电管41之间的光路的通断，达到更好的控光效果，避免对光电管41造成伤害，延长其使用寿命。
参考图1至图13，本发明的工作过程如下，反应杯放置区60主要用于放置反应杯8，开始时，反应杯座2处于放杯位置，吸嘴52下降通过负压从反应杯放置区60吸取反应杯8，然后沿X向滑动至置杯槽20上方，然后吸嘴 52下降，将反应杯8放入置杯槽20中。
然后丝杆电机30复位，使反应杯座2从放杯位置移动到检测位置，同时将反应杯8带入暗室10内，同时完成对进出口11的封闭，再通过底物加注接头15朝反应杯8内加入底物液，随后通过检测机构4完成液体发光检测。
检测完成之后，丝杆电机30工作，使反应杯座2从检测位置移动到丢杯位置，同时X向驱动电机5b工作，使竖板53靠近推臂7，并带动推臂7沿远离反应杯放置区60的方向滑动，拨动头720伸入置杯槽20内，将反应杯8从丢杯口22处推出，从而实现反应杯8的弃杯，接着反应杯座2再在丝杆电机30带动下回到放杯位置，同时吸嘴52回到反应杯放置区60上方，准备下一反应杯8的检测。
最后需要说明的是，上述描述仅仅为本发明的优选实施例，本领域的普通技术人员在本发明的启示下，在不违背本发明宗旨及权利要求的前提下，可以做出多种类似的表示，这样的变换均落入本发明的保护范围之内。

Claims (10)

  1. 一种磁微粒化学发光免疫分析仪暗箱检测系统，其特征在于，包括：
    基板(6)；
    检测暗箱(1)，其设置于基板(6)上，内部设有暗室(10)，所述暗室(10)的一侧开设有进出口(11)；
    反应杯座(2)，其设置于基板(6)上，具有用于放置反应杯的置杯槽(20)，所述反应杯座(2)可相对检测暗箱(1)滑动以打开或封闭进出口(11)，反应杯座(2)在其滑动行程内具有检测和放杯位置，当反应杯座(2)位于检测位置时，置杯槽(20)处于暗室(10)内，进出口(11)封闭，当反应杯座(2)位于放杯位置时，置杯槽(20)处于暗室(10)外，进出口(11)打开；
    驱动机构(3)，用于驱动反应杯座(2)滑动；
    检测机构(4)，用于检测暗室(10)中反应杯内液体的发光量；
    移送装置，用于将反应杯放入置杯槽(20)或将置杯槽(20)的反应杯移出。
  2. 根据权利要求1所述的磁微粒化学发光免疫分析仪暗箱检测系统，其特征在于：所述驱动机构(3)包括丝杆电机(30)，所述丝杆电机(30)位于检测暗箱(1)的一侧，其丝杆(300)延伸方向与反应杯座(2)的滑动方向一致，所述反应杯座(2)与丝杆(300)螺纹配合。
  3. 根据权利要求2所述的磁微粒化学发光免疫分析仪暗箱检测系统，其特征在于：所述丝杆(300)下方固设有与其平行的杯座导轨(31)，所述杯座导轨(31)上具有与其滑动配合的杯座滑块(32)，所述反应杯座(2)与杯座滑块(32)固定连接。
  4. 根据权利要求2或3所述的磁微粒化学发光免疫分析仪暗箱检测系统，其特征在于：所述丝杆(300)靠近丝杆电机(30)一端的上方设有电机复位 传感器(33)，所述反应杯座(2)上设有与电机复位传感器(33)适配的触发片(21)。
  5. 根据权利要求2所述的磁微粒化学发光免疫分析仪暗箱检测系统，其特征在于：所述反应杯座(2)在其滑动行程内还具有丢杯位置，且所述置杯槽(20)的一侧敞口形成丢杯口(22)，所述移送装置包括活动设置于基板(6)上的推臂(7)，所述推臂(7)可沿丢杯口(22)的朝向移动，反应杯座(2)处于丢杯位置时，所述推臂(7)移动可将置杯槽(20)内的反应杯从丢杯口(22)处推出。
  6. 根据权利要求5所述的磁微粒化学发光免疫分析仪暗箱检测系统，其特征在于：所述移送装置还包括抓手机构(5)，所述抓手机构(5)包括支撑梁(51)和吸嘴(52)，所述支撑梁(51)上设有用于驱动吸嘴(52)沿其长度方向水平移动的X向驱动组件，以及沿其高度方向运动的Z向驱动组件，所述支撑梁(51)位于进出口(11)正对的一侧，且支撑梁(51)与丝杆(300)相互垂直。
  7. 根据权利要求6所述的磁微粒化学发光免疫分析仪暗箱检测系统，其特征在于：所述X向驱动组件包括沿支撑梁(51)长度方向设置的X向滑轨(5a)，以及位于支撑梁(51)一端的X向驱动电机(5b)，所述X向滑轨(5a)具有与其滑动配合的X向第一滑块(5c)，所述X向第一滑块(5c)上具有与其固定连接的竖板(53)；
    所述Z向驱动组件包括沿竖板(53)高度方向设置的Z向滑轨(5d)，所述Z向滑轨(5d)上具有与其滑动配合的Z向滑块(5e)，所述竖板(53)上设有驱动Z向滑块(5e)沿Z向滑轨(5d)滑动的Z向驱动电机(5f)，所述吸嘴(52)与Z向滑块(5e)固定连接。
  8. 根据权利要求7所述的磁微粒化学发光免疫分析仪暗箱检测系统，其 特征在于：所述推臂(7)通过X向第二滑块(5g)与X向滑轨(5a)滑动配合，所述竖板(53)上具有金属件(530)，推臂(7)上具有正对金属件(530)设置的上部磁铁(73)，当X向第一滑块(5c)在X向驱动电机(5b)驱动下靠近X向第二滑块(5g)时，所述金属件(530)与上部磁铁(73)相互吸引以带动推臂(7)沿X向滑轨(5a)滑动。
  9. 根据权利要求8所述的磁微粒化学发光免疫分析仪暗箱检测系统，其特征在于：所述X向滑轨(5a)上在推臂(7)的前后两侧分别设有前限位结构(54)和后限位结构(55)，所述推臂(7)具有正对前限位结构(54)设置的下部磁铁(70)。
  10. 根据权利要求5所述的磁微粒化学发光免疫分析仪暗箱检测系统，其特征在于：所述检测暗箱(1)对应进出口(11)设有向外延伸的挡片(12)，所述挡片(12)位于丢杯口(22)正对的一侧，当反应杯座(2)处于放杯位置时，所述挡片(12)位于丢杯口(22)的正前方，所述反应杯座(2)正对挡片(12)的位置设有让位孔(23)。
PCT/CN2020/072124 2019-02-20 2020-01-15 磁微粒化学发光免疫分析仪暗箱检测系统 WO2020168864A1 (zh)

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