Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
  • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
  • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
  • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
  • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
  • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
  • A61K8/9783—Angiosperms [Magnoliophyta]
  • A61K8/9789—Magnoliopsida [dicotyledons]
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q5/00—Preparations for care of the hair
  • A61Q5/02—Preparations for cleaning the hair

Definitions

• the present invention relates to a hair cleansing composition.
• an azole antifungal agent such as miconazole has an antibacterial effect against Malassezia bacterium, which is one of the indigenous bacteria of the scalp
• a hair cleansing composition containing the azole antifungal agent as an antidandruff agent is commercially available.
• the stability of the azole antifungal agent with time may deteriorate due to coexisting components such as a surfactant in the hair cleansing composition.
• a hair cleansing composition which has excellent retention of the azole antifungal agent, can sufficiently obtain the effect thereof, and can maintain the stability of the azole antifungal agent.
• a hair cleansing composition which has excellent retention of the azole antifungal agent, can sufficiently obtain the effect thereof, and can maintain the stability of the azole antifungal agent.
• the present invention aims to solve the above-mentioned problems in the past and achieve the following objects. That is, it is an object of the present invention to provide a hair cleansing composition which is excellent in the effect of improving dandruff and itch and has excellent storage stability at high temperatures.
• a carboxylate type anionic surfactant (B) an amphoteric surfactant, and (C) dimethyldiallylammonium chloride. From a polymer and at least one cationic polymer selected from dimethyldiallylammonium chloride-acrylic acid copolymer, (D) an azole antifungal agent, and (E) rosemary extract, phenoxyethanol, and assembly extract At least one selected from the group consisting of dimethyldiallylammonium chloride-acrylic acid copolymer (C), wherein the molar ratio of structural units derived from dimethyldiallylammonium chloride is 65 mol% or more.
• the present inventors have found that a hair cleansing composition has an excellent effect of improving dandruff and itchiness, and also has excellent storage stability at high temperatures, and has completed the present invention.
• the present invention is based on the above findings by the present inventors, and means for solving the above problems are as follows. That is, (A) a carboxylate type anionic surfactant, (B) an amphoteric surfactant, (C) at least one cationic polymer selected from dimethyldiallylammonium chloride polymer and dimethyldiallylammonium chloride-acrylic acid copolymer; (D) an azole antifungal agent, (E) at least one selected from the group consisting of rosemary extract, phenoxyethanol, and assembly extract,
• the hair cleansing composition is characterized in that the dimethyldiallylammonium chloride-acrylic acid copolymer as the component (C) has a molar ratio of structural units derived from dimethyldiallylammonium chloride of 65 mol% or more.
• the hair cleansing composition of the present invention comprises (A) a carboxylate type anionic surfactant, (B) an amphoteric surfactant, (C) a cationic polymer, and (D) an azole antifungal agent. And (E) at least one selected from the group consisting of rosemary extract, phenoxyethanol, and assembly extract, and, if necessary, further contains other components.
• the carboxylic acid salt type anionic surfactant as the component (A) can be contained in order to improve the effect of improving dandruff and itch.
• the component (A) is not particularly limited and may be appropriately selected depending on the intended purpose.
• examples thereof include ethercarboxylic acid type surfactants and amino acid type surfactants. These may be used alone or in combination of two or more. Among these, ethercarboxylic acid type surfactants are preferable.
• Ether carboxylic acid type surfactant is appropriately selected depending on the intended purpose without any limitation, and examples thereof include compounds represented by the following general formula (A1) or (A2).
• the ethercarboxylic acid type surfactants may be used alone or in combination of two or more.
• R 2 represents a linear or branched alkyl or alkenyl group, or a phenyl group substituted with a linear or branched alkyl or alkenyl group.
• the carbon number of R 2 is not particularly limited and may be appropriately selected depending on the intended purpose, but is preferably 10 to 14 and more preferably 11 to 13 from the viewpoint of the effect of improving dandruff and itch.
• R 3 represents an alkylene group.
• the carbon number of R 3 is not particularly limited and may be appropriately selected depending on the intended purpose, but is preferably 2 to 4, and more preferably 2.
• the R 3 s may be the same as or different from each other.
• o represents the average number of moles of alkylene oxide added.
• the average number of moles of alkylene oxide added is not particularly limited and may be appropriately selected depending on the intended purpose, but is preferably 1 to 10 and more preferably 3 to 6 from the viewpoint of the effect of improving dandruff and itch. ..
• M 1 represents a hydrogen atom, an alkali metal, an alkaline earth metal, an alkanolamine, ammonium or a basic amino acid.
• alkali metals are preferable, and sodium is more preferable.
• ether carboxylic acid type surfactant represented by the general formula (A1) or (A2) include polyoxyethylene alkyl ether acetate such as polyoxyethylene lauryl ether acetate and lauryl glycol acetate. Such alkyl glycol acetates and the like can be mentioned.
• the ethercarboxylic acid type surfactant is preferably polyoxyethylene alkyl ether acetate in terms of the effect of improving dandruff and itch.
• the ethercarboxylic acid type surfactant may be appropriately synthesized or may be a commercially available product.
• Examples of commercial products of the ether carboxylic acid type surfactants include Enadicol EC-30 (sodium polyoxyethylene lauryl ether acetate, manufactured by Lion Corporation), Beaulite LCA-25F (sodium polyoxyethylene lauryl ether acetate), Beaulite LCA (sodium polyoxyethylene lauryl ether acetate), Beaulite LCA-30D (sodium polyoxyethylene lauryl ether acetate), Beaulite LCA-H (polyoxyethylene lauryl ether acetate), Beaulite LCA-25NH (laureth- 4 carboxylic acid), Beaulite SHAA (sodium lauryl glycol carboxylate) (above, Sanyo Kasei Co., Ltd.), Kao Akipo RLM-45 NV (polyoxyethylene lauryl ether sodium acetate (average number of moles of ethylene oxide (EO) added):
• the amino acid type surfactant is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include compounds represented by general formula (A3) shown below.
• the amino acid type surfactants may be used alone or in combination of two or more.
• R 2 represents a linear or branched alkyl group or alkenyl group, or a phenyl group substituted with a linear or branched alkyl group or alkenyl group.
• the carbon number of R 2 is not particularly limited and may be appropriately selected depending on the intended purpose, but is preferably 5 to 23, more preferably 8 to 18.
• R 4 represents a hydrogen atom or an alkyl group.
• R 4 is an alkyl group, the number of carbon atoms is not particularly limited and may be appropriately selected depending on the intended purpose, but is preferably 1 to 3.
• R 5 and R 6 represent a hydrogen atom or —(CH 2 ) m —COOM 2 .
• the R 5 and the R 6 may be the same or different from each other.
• m and n are numbers from 0 to 20.
• the m and n may be the same or different from each other.
• M 1 and M 2 represent a hydrogen atom, an alkali metal, an alkaline earth metal, an alkanolamine, ammonium or a basic amino acid.
• the M 1 and the M 2 may be the same as or different from each other.
• the amino acid structure of the hydrophilic part of the amino acid type surfactant is not particularly limited and may be appropriately selected depending on the intended purpose, but glycine, glutamic acid, methylalanine and the like are preferable.
• amino acid type surfactant represented by the general formula (A3) include N-acyl-glycine such as N-cocoyl-glycine potassium (N-coconut oil fatty acid acylglycine potassium) or a salt thereof; N- N-acyl-N-carboxyethyl-glycine such as myristoyl-N-carboxyethyl-glycine sodium or a salt thereof; sodium N-myristoyl-L-glutamate, potassium N-myristoyl-L-glutamate, N-lauroyl-L-glutamic acid Sodium, sodium myristoylmethylaminoacetate, potassium N-coconut oil fatty acid acyl-L-glutamate, sodium N-coconut oil fatty acid acyl-L-glutamate, sodium N-palm fatty acid acyl-L-glutamate, N-stearoyl-L-glutamic acid N-acyl glutamic acid such as sodium or a salt thereof;
• the amino acid type surfactants are preferably N-acyl sarcosine salts, N-acyl alanine salts, N-acyl glutamate salts, N-acyl aspartate salts and the like from the viewpoint of the effect of improving dandruff and itch.
• the amino acid type surfactant may be appropriately synthesized or may be a commercially available product.
• Examples of commercially available amino acid type surfactants include Amisoft (registered trademark) CS-11 (N-myristoyl-L-sodium glutamate), Amisoft (registered trademark) CS-22 (N-coconut oil fatty acid acyl-L).
• the content of the component (A) is not particularly limited and may be appropriately selected depending on the intended purpose, but from the viewpoint of the effect of improving dandruff and itch, it is 1 relative to the total amount of the hair cleaning composition. Mass% to 20 mass% is preferable, and 5 mass% to 11 mass% is more preferable. When the content of the component (A) is 1% by mass to 20% by mass, the effect of improving dandruff and itch is good.
• amphoteric surfactant as the component (B) can be contained in order to improve the effect of improving dandruff and itch.
• the component (B) is not particularly limited and may be appropriately selected depending on the intended purpose.
• examples thereof include betaine-type amphoteric surfactants and amino acid-type amphoteric surfactants. These may be used alone or in combination of two or more. Among these, betaine-type amphoteric surfactants are preferable from the viewpoint of the effect of improving dandruff and itch.
• the betaine-type amphoteric surfactant is not particularly limited and may be appropriately selected depending on the purpose, for example, alkylbetaine-type amphoteric surfactant, amidobetaine-type amphoteric surfactant, sulfobetaine-type amphoteric surfactant.
• the alkylbetaine-type amphoteric surfactant is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include lauryldimethylaminoacetic acid betaine, coconut oil alkylbetaine and stearyldimethylaminoacetic acid betaine.
• amidobetaine-type amphoteric surfactant is not particularly limited and may be appropriately selected depending on the intended purpose. Examples include lauric acid amidopropyl betaine, coconut oil fatty acid amidopropyl betaine, and palm kernel oil fatty acid amidopropyl betaine. Is mentioned.
• the sulfobetaine-type amphoteric surfactant is not particularly limited and may be appropriately selected depending on the intended purpose.
• lauryl hydroxysulfobetaine lauramidopropyl hydroxysultaine, coconut oil fatty acid dimethylaminohydroxysulfobetaine, etc. Is mentioned.
• the hydroxysulfobetaine-type amphoteric surfactant is not particularly limited and may be appropriately selected depending on the purpose, for example, coconut oil fatty acid dimethylaminohydroxysulfobetaine, lauryldimethylaminohydroxysulfobetaine, laurylhydroxysulfobetaine. And so on.
• amidosulfobetaine-type amphoteric surfactant is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include alkylamidopropyl betaine. Examples of the alkylamidopropyl betaine include coconut oil fatty acid amidopropyl betaine (cocamidopropyl betaine), lauric acid amidopropyl betaine, and isostearamidopropyl betaine.
• the phosphobetaine-type amphoteric surfactant is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include alkylhydroxyphosphobetaine. Examples of the alkyl hydroxyphosphobetaine include lauryl hydroxyphosphobetaine, myristyl hydroxyphosphobetaine, stearyl hydroxyphosphobetaine, and the like.
• the imidazolinium betaine-type amphoteric surfactant is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium and N- Examples include coconut oil fatty acid acyl-N′-carboxymethyl-N′-hydroxyethylethylenediamine sodium, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and the like.
• the component (B) is preferably an alkylbetaine-type amphoteric surfactant, an amidobetaine-type amphoteric surfactant, an imidazolinium-betaine-type amphoteric surfactant, etc. from the viewpoint of the effect of improving dandruff and itching.
• Lauryl dimethylamino acetic acid betaine, lauric acid amidopropyl betaine, coconut oil fatty acid amidopropyl betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and the like are more preferable.
• component (B) those appropriately synthesized may be used, or commercially available products may be used.
• commercially available products of the component (B) include Enadicol L-30B (lauric acid amidopropyl betaine solution) (manufactured by Lion Corporation), Amhithol 20AB (lauric acid amidopropyl betaine), and Amhithol 55AB (cocamidopropyl betaine).
• Amphitol 20YB (2-alkyl-N-carboxymethyl-N-hydroxyetherimidazolinium betaine), Amphitol 20BS (lauryl betaine) (above, manufactured by Kao Corporation), Levon 2000L (lauric amide propyl betaine solution), Levon 2000 (coconut oil fatty acid amidopropyl betaine solution), levon CIB (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine), levon 105 (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazo) Rinium betaine) (above, manufactured by Sanyo Kasei Co., Ltd.), softazoline LPB (lauric acid amide propyl betaine solution), softazoline CPB (coconut oil fatty acid amide propyl betaine solution), softazoline CPB-R (coconut oil fatty acid amide propyl betaine solution) ), softazoline CH (2-alkyl-N
• the content of the component (B) is not particularly limited and may be appropriately selected depending on the intended purpose. From the viewpoint of the effect of improving dandruff and itch, it is 1 relative to the total amount of the hair cleaning composition.
• the content is preferably 20% by mass to 20% by mass, more preferably 2.5% by mass to 10% by mass.
• the content of the component (B) is 1% by mass to 20% by mass, the effect of improving dandruff and itch is good.
• the mass ratio of the content (mass %) of the component (A) to the content (mass %) of the component (B) represented by [(A)/(B)] is not particularly limited. It can be appropriately selected according to the purpose, but from the viewpoint of the effect of improving dandruff and itch, 0.8 to 16 is preferable, and 1 to 8 is more preferable. When the mass ratio is 0.8 to 16, the effect of improving dandruff and itch is good.
• the cationic polymer of the component (C) is at least one selected from a dimethyldiallylammonium chloride polymer and a dimethyldiallylammonium chloride-acrylic acid copolymer, in order to improve the effect of improving dandruff and itch. Can be included.
• the molar ratio of the structural units derived from dimethyldiallylammonium chloride in the dimethyldiallylammonium chloride-acrylic acid copolymer of the component (C) is 65 mol% or more from the viewpoint of the effect of improving dandruff and itch. And is preferably 95 mol% or more. If the molar ratio is less than 65 mol %, the effect of improving dandruff and itch cannot be felt.
• the dimethyldiallylammonium chloride-acrylic acid copolymers may be used alone or in combination of two or more.
• the molar ratio of each structural unit in the dimethyldiallylammonium chloride-acrylic acid copolymer of the component (C) can be determined by measurement by nuclear magnetic resonance (NMR) under the following measurement conditions.
• NMR nuclear magnetic resonance
• Solvent Heavy water (D 2 O)
• Measuring device JNM-LA300 (300 MHz, manufactured by JEOL Ltd.)
• the weight average molecular weight of the cationic polymer of the component (C) is appropriately selected depending on the intended purpose without any limitation, but it is preferably 10,000 to 1,000,000, and preferably 15,000 to 450. 1,000 is more preferable.
• the weight average molecular weight of the cationic polymer as the component (C) is, for example, SEC-MALLS-RI system (measurement condition: column: TSK gel ⁇ series ⁇ -M column 30 cm manufactured by Tosoh Corporation, solvent: 0.3 M aqueous solution of sodium nitrate). Can be measured at.
• the viscosity of the solution of the cationic polymer as the component (C) having a solid content of 30% by mass to 44% by mass at 25°C is not particularly limited and may be appropriately selected depending on the intended purpose, but is 10 mPa ⁇ s. ⁇ 15,000 mPa ⁇ s is preferable, and 20 mPa ⁇ s to 12,000 mPa ⁇ s is more preferable.
• the viscosity can be measured using, for example, a Brookfield viscometer LVF (manufactured by Brookfield).
• cationic polymer As the cationic polymer as the component (C), those appropriately synthesized may be used, or commercially available products may be used. Examples of the commercially available products include the following. MERQUAT 100 (dimethyldiallylammonium chloride polymer, manufactured by Lubrizol Co., solid content 39 mass% to 44 mass%, viscosity at 25° C.: 8,000 mPa ⁇ s to 12,000 mPa ⁇ s, weight average molecular weight: 150,000). The viscosity was measured by using a Brookfield viscometer LVF (manufactured by Brookfield) at 25° C. at spindle No. It can be measured using a rotor of 3 and a condition of 6 revolutions/minute.
• LVF Brookfield viscometer
• the viscosity was measured using a Brookfield viscometer LVF (manufactured by Brookfield) at 25° C. at spindle No. 4 rotors can be used and it can measure at the conditions of 30 rotations/minute.
• the viscosity was measured using a Brookfield viscometer LVF (manufactured by Brookfield) at 25° C. at spindle No. 4 rotors can be used and it can measure at the conditions of 60 rotations/minute.
• the content of the component (C) is not particularly limited and may be appropriately selected depending on the intended purpose, but is preferably 0.1% by mass to 5% by mass with respect to the total amount of the hair cleaning composition. , 0.3 mass% to 2 mass% is more preferable, and 0.5 mass% to 1 mass% is particularly preferable. When the content of the component (C) is 0.1% by mass to 5% by mass, the effect of improving dandruff and itch is good.
• the azole antifungal agent of the component (D) can be contained in order to improve the effect of improving dandruff and itch.
• the component (D) is appropriately selected depending on the intended purpose without any limitation, provided that it is an azole antifungal agent.
• miconazole, clotrimazole, econazole, thioconazole, oxyconazole, bifonazole. Lanoconazole, luliconazole, isoconazole, ketoconazole, fluconazole, itraconazole, neticonazole, sulconazole, phosfluconazole, voriconazole, croconazole, or salts thereof. These may be used alone or in combination of two or more.
• the salts are not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include nitrates and hydrochlorides.
• the component (D) is preferably miconazole and/or a salt thereof, and more preferably miconazole nitrate, from the viewpoint of the effect of improving dandruff and itch.
• component (D) those synthesized appropriately may be used, or commercially available products may be used.
• the commercially available product include miconazole nitrate (manufactured by Nagase & Co., Ltd.) and the like.
• the content of the component (D) is not particularly limited and may be appropriately selected depending on the intended purpose, but from the viewpoint of the effect of improving dandruff and itchiness, and storage stability at high temperatures, the hair cleansing composition
• the amount is preferably 0.1% by mass to 1% by mass, more preferably 0.5% by mass to 1% by mass, based on the total amount of the product.
• the content of the component (D) is 0.1% by mass or more, the effect of improving dandruff and itching is good, and when it is 1% by mass or less, the high temperature storage stability is good.
• the component (E) is preferably rosemary extract, phenoxyethanol and the like, and phenoxyethanol is more preferable from the viewpoint of storage stability at high temperature.
• the component (E) may be appropriately synthesized or may be a commercially available product.
• the commercially available products include Newpol EFP (phenoxyethanol, manufactured by Sanyo Kasei Co., Ltd.), Leomile WL (rosemary extract, manufactured by Toyoda Fragrance Co., Ltd.), assembly extract liquid ET (assembly extract), assembly extract liquid SS ( Assembly extract) (above, manufactured by Maruzen Pharmaceutical Co., Ltd.) and the like.
• the content of the component (E) is not particularly limited and may be appropriately selected depending on the intended purpose. However, from the viewpoint of storage stability at high temperature, it is 0.1% based on the total amount of the hair cleaning composition. The mass% to 2 mass% is preferable, and the mass% to 1 mass% is more preferable. When the content of the component (E) is 0.1% by mass to 2% by mass, the high temperature stability is good.
• the other components in the hair cleansing composition are not particularly limited as long as they do not impair the effects of the present invention, and can be appropriately selected from the components used in ordinary hair cleansing compositions. , Solvents (purified water, etc.), surfactants other than the components (A) and (B), oils, thickeners such as carboxymethyl cellulose, hydroxyethyl cellulose, citric acid, chelating agents (ethylenediaminetetraacetic acid (EDTA)) Etc.), opacifying agents (ethylene glycol diisostearate, fish scales, mica flakes, etc.), pigments, preservatives, antifungal agents, cooling agents, fragrances, and fragrance compositions.
• the hair cleansing composition preferably contains purified water.
• Examples of the surfactant other than the component (A) and the component (B) include compounds represented by the following general formula (1).
• R 1 represents a linear or branched alkyl group or an alkenyl group, but a linear or branched alkyl group is preferable, and a linear alkyl group is more preferable.
• the carbon number of R 1 is not particularly limited and may be appropriately selected depending on the intended purpose, but is preferably 8 to 18, and more preferably 11 to 13.
• R 2 and R 3 each independently represent a linear or branched alkyl group or a hydroxyalkyl group, and a linear or branched alkyl group is preferable, and a linear alkyl group is preferable. An alkyl group is more preferable, and a methyl group is particularly preferable.
• R 2 and R 3 may be the same as or different from each other.
• the carbon number of R 2 is not particularly limited and may be appropriately selected depending on the intended purpose, but is preferably 1 to 3.
• the carbon number of R 3 is not particularly limited and may be appropriately selected depending on the intended purpose, but is preferably 1 to 3.
• the compound represented by the general formula (1) is preferably an alkyldimethylamine oxide in which the alkyl chain length of R 1 in the general formula (1) is 8 to 18, and the compound represented by the general formula (1) is Alkyl dimethylamine oxide having an alkyl chain length of R 1 of 11 to 13 is more preferable.
• those appropriately synthesized may be used, or commercially available products may be used.
• commercially available products include Unisafe A-LM (lauryldimethylamine oxide), Unisafe A-LMR (lauryldimethylamine oxide), Unisafe A-LE (dihydroxyethyllaurylamine oxide), Unisafe A-SM (stearyldimethylamine) Oxide) (above, NOF Corporation), Amphitol 20N (lauryldimethylamine oxide, manufactured by Kao Corporation), Sophthamine L (lauryldimethylamine oxide, manufactured by Toho Chemical Industry Co., Ltd.), Genaminox K-12 (lauryldimethyl).
• Amine oxide genaminox KC (cocoamine oxide) (all manufactured by Clariant Japan Co., Ltd.), adecamine LDM (lauryldimethylamine oxide, manufactured by ADEKA Co., Ltd.), AX agent CS (lauryldimethylamine oxide), Cadenax DM12D-W (Lauryl dimethylamine oxide) (above, manufactured by Lion Specialty Chemicals Co., Ltd.), Standamox C1214 (lauryl dimethylamine oxide, manufactured by Cognis (BASF)), and the like.
• the content of the other components is not particularly limited as long as the effect of the present invention is not impaired, and can be appropriately selected according to the purpose.
• the hair cleansing composition has the above general formula (1).
• the content thereof is preferably 0.1% by mass to 4% by mass, more preferably 0.4% by mass to 4% by mass, based on the total amount of the hair cleansing composition. ..
• the hair cleansing composition of the present invention is excellent in high-temperature stability, and is advantageous in that the effect of the component (D) can be sufficiently obtained.
• the high-temperature stability can be confirmed on the basis of the quantitative value obtained by performing an accelerated test on the hair cleaning composition and quantifying the content of the component (D) before and after the accelerated test.
• the method described in the following examples can be used for the acceleration test and the method for quantifying the content of the component (D).
• the method for producing the hair cleansing composition of the present invention is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include the component (A), the component (B) and the component (C). , The component (D), the component (E), and further, if necessary, the other components are mixed and dissolved to produce the composition.
• the hair cleansing composition may be manufactured using an apparatus.
• the device is not particularly limited and may be appropriately selected depending on the purpose. Examples thereof include a stirring device having a shearing force and equipped with a stirring blade capable of mixing the whole.
• the stirring blade is not particularly limited and may be appropriately selected depending on the purpose, and examples thereof include a propeller, a turbine, and a disper.
• the hair cleansing composition of the present invention has an excellent effect of improving dandruff and itchiness and excellent storage stability at high temperatures, it can be widely used in shampoos, rinse-in shampoos, conditioning shampoos, treatment-in shampoos and the like. it can.
• Hair cleansing compositions having the compositions and contents shown in Tables 1 to 4 below were prepared by the following method. Specifically, the component (A) or the comparative component of the component (A), the component (B), the comparative component of the component (C) or the component (C), the component (D), the component (E) or the component (E). Comparative hair ingredients and purified water as common ingredients were mixed and dissolved to prepare respective hair cleansing compositions of Examples and Comparative Examples.
• the ratio (%) of the quantitative value of the content of the active ingredient after the acceleration test to the quantitative value of the content of the active ingredient before the acceleration test (hereinafter, may be referred to as “initial value”) is as follows. "High temperature storage stability” was evaluated according to the following evaluation criteria, which was obtained based on the formula (1).
• Ratio (%) of the content of the active ingredient after the acceleration test to the initial value (quantitative value of the content of the active ingredient after the acceleration test)/(quantitative value of the content of the active ingredient before the acceleration test) ⁇ 100 ..Formula (1) [HPLC measurement conditions] ⁇ Apparatus High-pressure pump: LC-20AD (Shimadzu Corporation) Autosampler: SIL-20A (manufactured by Shimadzu Corporation) Column oven: CTO-20A (Shimadzu Corporation) UV detector: SPD-M20A (manufactured by Shimadzu Corporation) (measurement wavelength: 230 nm) ⁇ Column: Octadecylsilylated silica gel column (GL Science Co., Ltd.) ⁇ Column temperature: 40°C -Mobile phase: mixed solution of methanol/0.05 mol/L ammonium dihydrogen phosphate solution (4/1 (volume ratio)) ⁇ Flow rate: 1.3 mL/min ⁇ Injection volume: 10
• ⁇ The ratio of the content of the active ingredient after the acceleration test to the initial value is 95% or more and less than 98%.
• ⁇ After the acceleration test The ratio of the content of the active ingredient to the initial value is less than 95%.
• “ ⁇ ” or “ ⁇ ” has “high temperature storage stability”.
• the carboxylic acid salt type of the (A) component containing the azole antifungal agent of the (D) component was used.
• a highly hydrophobic coacervate composed of an anionic surfactant, the (B) amphoteric surfactant, and the cationic polymer of the (C) component is produced, and the coacervate precipitates during rinsing and is applied to the hair and scalp. It was considered that the close contact exerts an excellent antibacterial effect and an excellent effect of improving dandruff and itch.
• Examples of aspects of the present invention include the following. ⁇ 1> (A) a carboxylate-type anionic surfactant, (B) an amphoteric surfactant, (C) at least one cationic polymer selected from dimethyldiallylammonium chloride polymer and dimethyldiallylammonium chloride-acrylic acid copolymer; (D) an azole antifungal agent, (E) at least one selected from the group consisting of rosemary extract, phenoxyethanol, and assembly extract,
• the hair cleansing composition is characterized in that the dimethyldiallylammonium chloride-acrylic acid copolymer as the component (C) has a molar ratio of structural units derived from dimethyldiallylammonium chloride of 65 mol% or more.
• the mass ratio of the content of the component (A) to the content of the component (B) represented by [(A)/(B)] is 0.8 to 16.
• the hair cleansing composition described in ⁇ 3> From ⁇ 1> to ⁇ 2>, wherein the content of the component (A) is 5% by mass to 11% by mass, and the content of the component (B) is 2.5% by mass to 10% by mass.
• the hair cleansing composition according to any one of 1. ⁇ 4> The hair cleaning composition according to any one of ⁇ 1> to ⁇ 3>, wherein the content of the component (C) is 0.3% by mass to 2% by mass.
• the hair cleansing composition of the present invention has an excellent effect of improving dandruff and itchiness and excellent storage stability at high temperatures, it can be suitably used for shampoos, rinse-in shampoos, conditioning shampoos, treatment-in shampoos and the like. is there.

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• 2019
  • 2019-12-12 CN CN201980091980.1A patent/CN113423378A/zh active Pending
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