WO2020153782A3 - 박테리아 유래의 신규 리폭시게나아제에 의한 이수산화지방산의 생산 - Google Patents

박테리아 유래의 신규 리폭시게나아제에 의한 이수산화지방산의 생산 Download PDF

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Publication number
WO2020153782A3
WO2020153782A3 PCT/KR2020/001156 KR2020001156W WO2020153782A3 WO 2020153782 A3 WO2020153782 A3 WO 2020153782A3 KR 2020001156 W KR2020001156 W KR 2020001156W WO 2020153782 A3 WO2020153782 A3 WO 2020153782A3
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WO
WIPO (PCT)
Prior art keywords
fatty acid
dihydroxy fatty
bacteria
production
present
Prior art date
Application number
PCT/KR2020/001156
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English (en)
French (fr)
Other versions
WO2020153782A2 (ko
Inventor
오덕근
이진
Original Assignee
건국대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020190009628A external-priority patent/KR102131549B1/ko
Priority claimed from KR1020190009629A external-priority patent/KR102131550B1/ko
Priority claimed from KR1020190009627A external-priority patent/KR102120000B1/ko
Application filed by 건국대학교 산학협력단 filed Critical 건국대학교 산학협력단
Publication of WO2020153782A2 publication Critical patent/WO2020153782A2/ko
Publication of WO2020153782A3 publication Critical patent/WO2020153782A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

본 발명은 박테리아 유래의 신규 리폭시게나아제, 이를 이용하여 이수산화지방산을 생산하는 방법 및 그 생산용 조성물에 관한 것이다. 본 발명에 의하면, 현재까지 보고되지 않은 친환경적인 방법으로 이수산화지방산을 높은 생산성과 높은 수율로 생합성할 수 있다. 본 발명에 의해 생산된 이수산화지방산은 의약, 식품 및 화장품 등 다양한 산업 분야에서 유용하게 사용될 수 있으며, 신호전달물질로서, 인간을 포함한 동물 체내에서 다양한 생리활성 기능에 관여할 것으로 기대된다.
PCT/KR2020/001156 2019-01-25 2020-01-23 박테리아 유래의 신규 리폭시게나아제에 의한 이수산화지방산의 생산 WO2020153782A2 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
KR10-2019-0009629 2019-01-25
KR1020190009628A KR102131549B1 (ko) 2019-01-25 2019-01-25 박테리아 유래의 신규 리폭시게나아제에 의한 5,15-이수산화에이코사펜타엔산의 생산
KR10-2019-0009628 2019-01-25
KR1020190009629A KR102131550B1 (ko) 2019-01-25 2019-01-25 박테리아 유래의 신규 리폭시게나아제에 의한 레졸빈 d5의 생산
KR10-2019-0009627 2019-01-25
KR1020190009627A KR102120000B1 (ko) 2019-01-25 2019-01-25 박테리아 유래의 신규 리폭시게나아제에 의한 5,15-이수산화아라키돈산의 생산

Publications (2)

Publication Number Publication Date
WO2020153782A2 WO2020153782A2 (ko) 2020-07-30
WO2020153782A3 true WO2020153782A3 (ko) 2021-04-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2020/001156 WO2020153782A2 (ko) 2019-01-25 2020-01-23 박테리아 유래의 신규 리폭시게나아제에 의한 이수산화지방산의 생산

Country Status (1)

Country Link
WO (1) WO2020153782A2 (ko)

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE PROTEIN ANONYMOUS: "ipoxygenase [Archangium violaceum]", XP055803992, retrieved from GENBANK Database accession no. WP_043397944 *
DOBRIAN, A.D. ; LIEB, D.C. ; COLE, B.K. ; TAYLOR-FISHWICK, D.A. ; CHAKRABARTI, S.K. ; NADLER, J.L.: "Functional and pathological roles of the 12- and 15-lipoxygenases", PROGRESS IN LIPID RESEARCH., PERGAMON PRESS, PARIS., FR, vol. 50, no. 1, 1 January 2011 (2011-01-01), FR, pages 115 - 131, XP027576329, ISSN: 0163-7827 *
JOSEPH T. O’FLAHERTY, YUNGPING HU, RHONDA E. WOOTEN, DAVID A. HORITA, MICHAEL P. SAMUEL, MICHAEL J. THOMAS, HAIGUO SUN, IRIS J. ED: "15-Lipoxygenase Metabolites of Docosahexaenoic Acid Inhibit Prostate Cancer Cell Proliferation and Survival", PLOS ONE, vol. 7, no. 9, pages e45480, XP055724461, DOI: 10.1371/journal.pone.0045480 *
LANG ELKE, SCHUMANN PETER, TINDALL BRIAN J., MOHR KATHRIN I., SPRÖER CATHRIN: "Reclassification of Angiococcus disciformis, Cystobacter minus and Cystobacter violaceus as Archangium disciforme comb. nov., Archangium minus comb. nov. and Archangium violaceum comb. nov., unification of the families Archangiaceae and Cystobacteraceae, and emended descriptions of the families Myxo", INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, GB, vol. 65, no. Pt_11, 1 November 2015 (2015-11-01), GB, pages 4032 - 4042, XP055804000, ISSN: 1466-5026, DOI: 10.1099/ijsem.0.000533 *
MAAS RICHARD L, J, TURK N, J, OATESG A, BRASH ALAN R: "Formation of a novel dihydroxy acid from arachidonic acid by lipoxygenase-catalyzed double oxygenation in rat mononuclear cells and human leukocytes.", vol. 257, 25 June 1982 (1982-06-25), pages 7056 - 7067, XP055803996 *
SEO MIN-HO; KIM KYOUNG-ROK; OH DEOK-KUN: "Production of a novel compound, 10,12-dihydroxystearic acid from ricinoleic acid by an oleate hydratase fromLysinibacillus fusiformis", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 97, no. 20, 3 February 2013 (2013-02-03), Berlin/Heidelberg, pages 8987 - 8995, XP035328788, ISSN: 0175-7598, DOI: 10.1007/s00253-013-4728-x *

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