WO2020084697A1 - Auto-échantillonneur - Google Patents

Auto-échantillonneur Download PDF

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Publication number
WO2020084697A1
WO2020084697A1 PCT/JP2018/039394 JP2018039394W WO2020084697A1 WO 2020084697 A1 WO2020084697 A1 WO 2020084697A1 JP 2018039394 W JP2018039394 W JP 2018039394W WO 2020084697 A1 WO2020084697 A1 WO 2020084697A1
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WO
WIPO (PCT)
Prior art keywords
cleaning
cleaning container
container
sample
port
Prior art date
Application number
PCT/JP2018/039394
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English (en)
Japanese (ja)
Inventor
翔太郎 安藤
隆志 井上
Original Assignee
株式会社島津製作所
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社島津製作所 filed Critical 株式会社島津製作所
Priority to PCT/JP2018/039394 priority Critical patent/WO2020084697A1/fr
Priority to JP2020551753A priority patent/JP7136223B2/ja
Publication of WO2020084697A1 publication Critical patent/WO2020084697A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Definitions

  • the present invention relates to an autosampler that supplies a sample to be analyzed to an analyzer.
  • the needle of the autosampler collects a sample from a vial containing a sample to be analyzed, and injects the sample into the analysis channel of a liquid chromatograph.
  • the autosampler can continuously supply the samples contained in the plurality of vials to the analysis channel of the liquid chromatograph.
  • part of the sample may remain on the needle of the autosampler.
  • the residual sample adsorbed on the needle may be mixed with the sample supplied to the analysis channel in the next sample supply step.
  • the mixed residual sample affects the analysis result in the liquid chromatograph.
  • the components of the residual sample mixed in appear as minute peaks in the analysis result of the next sample. This phenomenon is called carryover. Carryover is required to be as small as possible for the performance of the autosampler.
  • the needle is washed before and after the sample suction process. Cleaning of the needle is performed by inserting the needle into the rinse port filled with the cleaning liquid. Alternatively, the cleaning of the needle is performed by suctioning and discharging the cleaning liquid with which the rinse port is filled by the needle (see, for example, Patent Document 1).
  • a liquid having a high cleaning effect is selected according to the analysis conditions or the type of sample. Then, as a material of the rinse port filled with the cleaning liquid, an appropriate material is selected according to the type of the cleaning liquid used. Alternatively, as a material for the rinse port, an appropriate material is selected according to the type of sample. For example, a material having chemical resistance to the cleaning liquid used is selected as the material of the rinse port. Further, when the sample is adsorbed on the rinse port, the sample becomes dirty and remains on the rinse port. Therefore, as the material of the rinse port, a material having weak adsorptivity to the sample is selected. JP, 2017-207391, A
  • the rinse port material an appropriate material is selected according to the type of cleaning solution used or the type of sample to be analyzed. Therefore, it may be necessary to change the material of the rinse port depending on the type of cleaning liquid used or the type of sample to be analyzed. Alternatively, it may be necessary to change the rinse port to a new one because the dirt adsorbed on the rinse port cannot be removed.
  • the conventional autosampler requires replacement of the entire rinse port. Therefore, the change range in the autosampler becomes large in order to replace the rinse port, and the replacement work takes time. Further, since the entire rinse port is replaced, the parts to be replaced are large and the replacement cost is high.
  • An object of the present invention is to provide an autosampler capable of reducing the time and cost required for exchanging a portion containing a cleaning liquid.
  • An autosampler includes an injection port for supplying a sample to be analyzed to an analyzer, a sample to be analyzed contained in a vial, and an injection port for the sample to be analyzed. And a cleaning unit for cleaning the needle.
  • the cleaning unit has a supply port, accommodates the cleaning liquid supplied through the supply port, and accommodates the cleaning container in which the needle requiring cleaning is inserted into the accommodated cleaning liquid, and the cleaning container.
  • a unit main body having a space for receiving the cleaning liquid overflowing from the cleaning container, and the cleaning container being detachably attached.
  • This autosampler has a cleaning unit that cleans the needle, and in the cleaning unit, the cleaning container is detachably attached to the unit body.
  • the cleaning container of the cleaning unit is replaced. Since the entire cleaning unit does not need to be replaced, the change range of the cleaning unit is small and the replacement portion is small. Therefore, it is possible to reduce the labor and cost for exchanging the portion containing the cleaning liquid.
  • the cleaning container may be attached to the unit body by a screw structure.
  • the washing container can be attached and detached only by tightening and releasing the screws.
  • the cleaning container may be rotatably attached to the unit body by a screw structure, and the cleaning container may be provided with an engaging portion that can be engaged with a tool for rotating the cleaning container.
  • the operator can attach and remove the cleaning container by engaging the tool with the engaging part of the cleaning container. Easy installation and removal of the cleaning container.
  • the engagement portion may include an opening for discharging the cleaning liquid at a predetermined level or higher in the cleaning container.
  • the engaging portion has both an application for engaging the tool and an application as a flow path for discharging the cleaning liquid, and the number of parts is reduced.
  • the cleaning container may be rotatably provided around a vertical rotation axis, and the opening may include a groove provided at an upper end of the cleaning container.
  • the operator can attach and detach the cleaning container by engaging the tool with the groove on the upper end of the cleaning container. Easy installation and removal of the cleaning container.
  • At least a part of the groove may be arranged above the upper end of the unit body with the cleaning container attached to the unit body.
  • part of the groove on the upper end of the cleaning container is located above the upper end of the unit body. The operator can easily attach and detach the cleaning container by engaging the tool with the upper end of the cleaning container.
  • the groove may include a first groove and a second groove provided at different positions in the circumferential direction with respect to the rotation axis.
  • a plurality of cleaning containers may be detachably provided in the unit body.
  • the needle is cleaned using the plurality of cleaning containers.
  • the plurality of cleaning containers include a first cleaning container made of a first material and a second cleaning container made of a second material different from the first material.
  • the screw structure includes first and second screw structures.
  • the plurality of cleaning containers include a first cleaning container fixed to the unit body by a first screw structure and a second cleaning container fixed to the unit body by a second screw structure, and a first screw structure.
  • the screw diameter of is different from the screw diameter of the second screw structure.
  • the multiple cleaning containers are fastened to the unit body by the screw structure. Then, as the screw structure of the plurality of cleaning containers, structures having different screw diameters are used. Thereby, in the work of mounting the plurality of cleaning containers, it is possible to prevent a work error such as accidentally mounting another cleaning container.
  • the labor and cost for exchanging the portion containing the cleaning liquid can be reduced.
  • FIG. 1 is an overall view showing a liquid chromatograph to which an autosampler according to the present embodiment is connected.
  • FIG. 2 is a side view of rinse port 1 according to the present embodiment.
  • FIG. 3 is a side sectional view of the rinse port 1.
  • FIG. 4 is a plan view of the rinse port 1.
  • FIG. 5 is a perspective view of the rinse port body 2 according to the present embodiment as seen obliquely from above.
  • FIG. 6 is a perspective view of the rinse port body 2 as viewed from diagonally below.
  • FIG. 7 is a plan view of the rinse port body 2.
  • FIG. 8 is a perspective view of the cleaning container 3A according to the present embodiment as seen obliquely from above.
  • FIG. 9 is a perspective view of the cleaning container 3A as seen obliquely from below.
  • FIG. 10 is a side sectional view of the cleaning container 3A.
  • FIG. 11 is a perspective view of the cleaning container 3B according to the present embodiment as seen obliquely from above.
  • FIG. 12 is a perspective view of the cleaning container 3B as seen obliquely from below.
  • FIG. 13 is a side sectional view of the cleaning container 3B.
  • FIG. 14 is a perspective view of rinse port cover 4 according to the present embodiment.
  • FIG. 15 is a plan view showing the cover cap 45 according to this embodiment.
  • FIG. 1 is an overall view showing a liquid chromatograph 8 to which an autosampler 7 according to the present embodiment is connected.
  • the liquid chromatograph 8 includes an autosampler 7, a column 81 and a detector 82.
  • the autosampler 7 includes a rinse port 1, a needle 73, an injection port 74, liquid supply tubes 52A and 52B, a liquid discharge tube 55, and pumps 75A and 75B. Outside the apparatus of the auto sampler 7, cleaning liquid tanks 76A and 76B and a drainage tank 77 are provided.
  • a sample plate 71 is arranged in the auto sampler 7.
  • a plurality of sample vials 72 are arranged on the sample plate 71.
  • the sample vial 72 contains a sample.
  • the needle 73 is movable between the sample vial 72, the rinse port 1 and the injection port 74.
  • the needle 73 collects a sample from the sample vial 72.
  • the needle 73 supplies the sample to the column 81 by injecting the sample into the injection port 74.
  • the needle 73 is washed in the rinse port 1 after the sample is injected into the injection port 74 or after the sample is taken from the sample vial 72.
  • Rinse port 1 contains cleaning containers 3A and 3B.
  • a liquid feeding tube 52A is connected to the cleaning container 3A.
  • the end of the liquid supply tube 52A is arranged inside the cleaning liquid tank 76A.
  • the pump 75A is connected to the liquid supply tube 52A between the cleaning container 3A and the cleaning liquid tank 76A. With this configuration, when the pump 75A is driven, the cleaning liquid in the cleaning liquid tank 76A is fed into the cleaning container 3A via the liquid feeding tube 52A.
  • the pump 75A is used as a cleaning liquid pump for feeding the cleaning liquid stored in the cleaning liquid tank 76A into the cleaning container 3A and as a metering pump for collecting and discharging a sample by the needle 73. Is also used as.
  • As the pump 75A for example, a pump capable of highly accurate flow rate adjustment is used. Note that, in FIG. 1, a valve, a liquid supply path, and the like provided between the pump 75A and the needle 73 are not shown.
  • a liquid delivery tube 52B is connected to the cleaning container 3B.
  • the end of the liquid supply tube 52B is arranged in the cleaning liquid tank 76B.
  • the pump 75B is connected to the liquid supply tube 52B between the cleaning container 3B and the cleaning liquid tank 76B. With this configuration, when the pump 75B is driven, the cleaning liquid in the cleaning liquid tank 76B is fed into the cleaning container 3B via the liquid feeding tube 52B.
  • pump 75B is a dedicated pump for feeding the cleaning liquid contained in cleaning liquid tank 76B into cleaning container 3B.
  • the pump 75B for example, a pump having a larger power than the pump 75A is used.
  • the liquid chromatograph 8 includes the column 81 and the detector 82.
  • the sample injected into the injection port 74 by the needle 73 is sent to the column 81.
  • the sample continuously fed from the autosampler 7 is supplied to the column 81.
  • the sample whose components have been separated in the column 81 is detected by the detector 82.
  • FIG. 2 is a side view of the rinse port 1.
  • FIG. 3 is a side sectional view of the rinse port 1.
  • FIG. 4 is a plan view of the rinse port 1.
  • arrows indicating the X direction, the Y direction and the Z direction orthogonal to each other are attached.
  • the X direction and the Y direction are orthogonal to each other in the horizontal plane, and the Z direction corresponds to the vertical direction.
  • the vertical direction when the rinse port 1 is attached to the autosampler 7 at a predetermined position is the vertical direction of the rinse port 1. Will be described.
  • the rinse port 1 includes a rinse port body 2 and washing containers 3A and 3B.
  • the cleaning containers 3A and 3B are arranged side by side in the X direction at intervals.
  • the rinse port body 2 includes a body upper portion 21 and a body lower portion 22.
  • the main body upper part 21 and the main body lower part 22 are integrally formed.
  • the main body upper part 21 has a tubular shape with an open upper end and a lower end.
  • the main body upper part 21 accommodates the cleaning containers 3A and 3B therein.
  • the upper ends of the cleaning containers 3A and 3B are arranged above the upper end of the main body upper part 21.
  • the lower part 22 of the main body has a shape with an open upper end. As shown in FIG. 3, the lower part 22 of the main body supports the lower ends of the cleaning containers 3A and 3B.
  • An inner space 20 of the rinse port body 2 is formed by the inner space of the upper body 21 and the inner space of the lower body 22. The internal space 20 receives the cleaning liquid overflowing from the cleaning containers 3A and 3B.
  • the lower portion of the lower body 22 has a first supply port 24A, a second supply port 24B, and a drainage port 23, which are cylindrical protrusions extending downward from the lower end of the lower body 22. It is provided.
  • the first supply port 24A is located below the cleaning container 3A.
  • the lower part 22 of the main body is opened downward through the cylindrical inner space in the first supply port 24A.
  • the second supply port 24B is located below the cleaning container 3B.
  • the lower part 22 of the main body is opened downward through the cylindrical inner space in the second supply port 24B.
  • the drainage port 23 is located between the first supply port 24A and the second supply port 24B in the X direction.
  • the lower part 22 of the main body is opened in the cylindrical inner space of the drainage port 23.
  • the drainage port 23 is connected to the internal space 20.
  • the upper end of the liquid supply tube 52A is inserted into the first supply port 24A.
  • the liquid feeding tube 52A is fixed to the lower portion 22 of the main body by the fastening members 51A and 53A. Threads are formed on the inner wall of the cylindrical member of the first supply port 24A, and threads are formed on the outer periphery of the fastening member 51A.
  • each of the fastening members 51A and 53A has a tube insertion hole penetrating in the up-down direction in the rotation center shaft portion, and the liquid feeding tube 52A is inserted into this tube insertion hole. With this structure, the fastening members 51A and 53A hold the liquid feeding tube 52A, and the fastening member 51A is fixed to the lower portion 22 of the main body by the screw structure.
  • the upper portion of the fastening member 53A has a taper shape in which the diameter decreases as it goes upward
  • the inner wall of the first supply port 24A also has a taper shape in which the diameter decreases as it goes upward.
  • the upper end of the liquid feeding tube 52B is inserted into the second supply port 24B.
  • the liquid feeding tube 52B is fixed to the lower portion 22 of the main body by the fastening members 51B and 53B. Threads are formed on the inner wall of the cylindrical member of the second supply port 24B, and threads are formed on the outer periphery of the fastening member 51B.
  • each of the fastening members 51B and 53B has a tube insertion hole that penetrates in the up-down direction in the central axis of rotation, and the liquid feeding tube 52B is inserted into this tube insertion hole. With this structure, the fastening members 51B and 53B hold the liquid feeding tube 52B, and the fastening member 51B is fixed to the lower portion 22 of the main body by the screw structure.
  • the outer periphery of the lower portion of the fastening member 53B is tapered so that the diameter becomes smaller as it goes downward, and the inner periphery of the upper portion of the fastening member 51B is tapered as it becomes larger as it goes upward. Then, the lower taper portion of the fastening member 53B and the upper taper portion of the fastening member 51B are arranged at positions overlapping in the vertical direction.
  • FIG. 5 is a perspective view of the rinse port body 2 as seen obliquely from above
  • FIG. 6 is a perspective view of the rinse port body 2 as seen from obliquely below
  • FIG. 7 is a plan view of the rinse port body 2.
  • the main body upper part 21 has a substantially rectangular parallelepiped shape, and has a substantially rectangular parallelepiped internal space 20.
  • a mounting plate 25 is provided between the upper body 21 and the lower body 22.
  • the mounting plate 25 has bolt holes at a plurality of locations.
  • the rinse port body 2 is fixed at a predetermined position in the auto sampler 7 by bolting the mounting plate 25 to a predetermined member in the auto sampler 7.
  • a drain port 23, a first supply port 24A, and a second supply port 24B extend downward from the lower end of the main body lower part 22.
  • a mounting plate 25 is provided on the lower portion 22 of the main body.
  • the mounting plate 25 has a substantially rectangular outer shape.
  • FIG. 7 is a figure which shows the state which removed washing container 3A, 3B from the rinse port 1 shown in FIG.
  • Container mounting holes 26A and 26B are provided on the bottom surface of the lower portion 22 of the main body. Threads for fixing the cleaning containers 3A, 3B are formed on the inner peripheral surfaces of the container mounting holes 26A, 26B, as described later.
  • FIG. 8 is a perspective view of the cleaning container 3A as seen obliquely from above.
  • FIG. 9 is a perspective view of the cleaning container 3A as viewed obliquely from below.
  • FIG. 10 is a side sectional view of the cleaning container 3A.
  • FIG. 11 is a perspective view of the cleaning container 3B as seen obliquely from above.
  • FIG. 12 is a perspective view of the cleaning container 3B as seen obliquely from below.
  • FIG. 13 is a side sectional view of the cleaning container 3B.
  • the washing containers 3A and 3B are housed in the rinse port main body 2 and the rinse port 1 is attached to the autosampler 7. It is assumed that the up and down direction in is the up and down direction of the cleaning containers 3A and 3B.
  • the cleaning container 3A has a cylindrical outer shape. Inside the cleaning container 3A, a storage portion 30A for storing a cleaning liquid is formed. Two protrusions 31A and 31A are provided on the upper end of the cleaning container 3A. Two grooves 32A and 32A are formed between the two protrusions 31A and 31A. As shown in FIG. 11, the cleaning container 3B also has a cylindrical outer shape. In the present embodiment, the vertical length of cleaning container 3B is longer than the vertical length of cleaning container 3A. A storage portion 30B for storing the cleaning liquid is formed inside the cleaning container 3B. Two protrusions 31B and 31B are also provided on the upper end of the cleaning container 3B. Two grooves 32B and 32B are formed between the two protrusions 31B and 31B.
  • a mounting portion 33A is provided at the lower end of the cleaning container 3A.
  • the mounting portion 33A extends downward from the lower end of the cleaning container 3A.
  • the mounting portion 33A is a cylindrical member, and a thread is formed on the outer peripheral portion thereof.
  • the screw structure 11A (see FIG. 3) is configured by the screw thread formed on the outer circumference of the mounting portion 33A and the screw thread formed on the inner circumference of the container mounting hole 26A described above.
  • the rotating shaft 35A in FIG. 10 is the rotating shaft of the cleaning container 3A that rotates when the cleaning container 3A is fastened by the screw structure 11A.
  • a cleaning liquid supply passage 331A is formed near the center of the cylinder of the attachment portion 33A. The cleaning liquid supply passage 331A is connected to the storage portion 30A.
  • a mounting portion 33B is provided at the lower end of the cleaning container 3B.
  • the mounting portion 33B extends downward from the lower end of the cleaning container 3B.
  • the mounting portion 33B is a cylindrical member, and a thread is formed on the outer peripheral portion thereof.
  • the screw structure 11B (see FIG. 3) is configured by the threads formed on the outer circumference of the mounting portion 33B and the threads formed on the inner circumference of the container mounting hole 26B.
  • the rotating shaft 35B in FIG. 13 is the rotating shaft of the cleaning container 3B that rotates when the cleaning container 3B is fastened by the screw structure 11B.
  • a cleaning liquid supply passage 331B is formed near the center of the cylinder of the mounting portion 33B.
  • the cleaning liquid supply passage 331B is connected to the housing portion 30B.
  • the cleaning liquid supply passage 331B is bent midway as shown in FIG.
  • a pump having a stronger power than the pump 75A is used in the present embodiment.
  • the lower portion 22 of the rinse port body 2 is provided with container mounting holes 26A and 26B.
  • the container mounting holes 26A and 26B are cylindrical holes, and threads are formed on the inner peripheral surfaces thereof.
  • the cleaning container 3A is fixed to the main body lower portion 22 of the rinse port main body 2 by inserting the mounting portion 33A of the cleaning container 3A into the container mounting hole 26A and tightening with the screw structure 11A.
  • the cleaning container 3B is fixed to the main body lower portion 22 of the rinse port main body 2 by inserting the mounting portion 33B of the cleaning container 3B into the container mounting hole 26B and tightening the screw structure 11B.
  • the lower ends of the cleaning containers 3A and 3B are fixed to the lower part 22 of the main body, and the cleaning containers 3A and 3B are housed in the internal space 20 of the rinse port main body 2.
  • O-rings 36A and 36B are fitted in the lower portions of the cleaning containers 3A and 3B to secure a hermetic seal between the accommodating portions 30A and 30B and the internal space 20.
  • the fastening member 51A is screwed to the first supply port 24A in a state where the liquid feeding tube 52A is inserted into the tube insertion holes of the fastening members 51A and 53A.
  • the liquid feeding tube 52A is connected to the main body lower portion 22 of the rinse port main body 2.
  • the liquid sending tube 52A is connected to the cleaning liquid supply passage 331A via the passage 27A in the lower portion 22 of the main body.
  • the liquid sending tube 52A is connected to the housing portion 30A of the cleaning container 3A via the flow path 27A and the cleaning liquid supply passage 331A.
  • the fastening member 51B is screwed to the second supply port 24B in a state where the liquid feeding tube 52B is inserted into the tube insertion holes of the fastening members 51B and 53B.
  • the liquid feeding tube 52B is connected to the main body lower portion 22 of the rinse port main body 2.
  • the liquid delivery tube 52B is connected to the cleaning liquid supply passage 331B via the passage 27B in the lower portion 22 of the main body.
  • the liquid supply tube 52B is connected to the housing portion 30B of the cleaning container 3B via the flow path 27B and the cleaning liquid supply passage 331B.
  • the liquid feeding tubes 52A and 52B are connected to the pumps 75A and 75B, respectively.
  • the pumps 75A and 75B are driven to send the cleaning liquid contained in the cleaning liquid tanks 76A and 76B to the first and second supply ports 24A and 24B via the liquid supply tubes 52A and 52B.
  • the cleaning liquid sent to the first supply port 24A via the liquid supply tube 52A flows into the housing portion 30A of the cleaning container 3A via the flow path 27A and the cleaning liquid supply passage 331A.
  • the cleaning liquid sent to the second supply port 24B via the liquid supply tube 52B flows into the housing portion 30B of the cleaning container 3B via the flow path 27B and the cleaning liquid supply passage 331B.
  • the rinse port 1 configured as described above is housed in the autosampler 7 as shown in FIG.
  • the needle 73 has a drive unit (not shown) and moves between the sample vial 72, the rinse port 1 and the injection port 74 under the control of a control unit (not shown).
  • the needle 73 is washed in either the washing container 3A or 3B in the rinse port 1 under the control of the controller.
  • the needle 73 is washed in the washing container 3A or 3B after collecting the sample in the sample vial 72 with the needle 73, for example.
  • the cleaning container 3A or 3B used for cleaning is filled with the cleaning liquid.
  • the needle 73 is washed with the washing liquid by entering the washing container 3A or 3B from above.
  • the needle 73 enters the cleaning container 3A or 3B, the sample or the like attached to the outer peripheral surface thereof is washed off.
  • the needle 73 is cleaned in the cleaning container 3A or 3B after the sample is injected into the injection port 74 by the needle 73, for example.
  • the needle 73 is washed in the washing container 3A or 3B before the step of collecting the next sample.
  • the cleaning liquid is filled in the cleaning container 3A or 3B used for cleaning at a timing before the needle 73 is cleaned in the cleaning container 3A or 3B.
  • the needle 73 is washed with the washing liquid by entering the washing container 3A or 3B from above. When the needle 73 enters the cleaning container 3A or 3B, the sample or the like attached to the outer peripheral surface thereof is washed off.
  • the needle 73 cleans the inside of the needle 73 by sucking and discharging the cleaning liquid in the cleaning container 3A or 3B.
  • the cleaning liquid in the cleaning container 3A or 3B overflows from the upper end of the cleaning container 3A or 3B.
  • the overflowed cleaning liquid flows into the internal space 20 of the rinse port body 2.
  • the cleaning liquid flowing into the internal space 20 flows into the drainage tube 55 via the drainage port 23.
  • the cleaning liquid flowing out to the drainage tube 55 is collected in the drainage tank 77.
  • the autosampler 7 of the present embodiment includes the rinse port 1 for cleaning the needle 73, and in the rinse port 1, the cleaning containers 3A and 3B are detachably attached to the rinse port body 2.
  • the rinse port 1 when it is necessary to change the material of the portion containing the cleaning liquid and when it is necessary to change the portion containing the cleaning liquid to a new one, only the cleaning container 3A or 3B is replaced. Since the entire rinse port 1 does not need to be replaced, the change range of the device is reduced and the labor of the work is reduced. Further, since only the cleaning container 3A or 3B is replaced, the parts to be replaced are small and the cost for replacement is small.
  • the cleaning containers 3A and 3B are attached to the rinse port body 2 by the screw structures 11A and 11B.
  • the washing containers 3A and 3B can be attached and detached only by fastening and releasing the screws.
  • the screw diameter of the screw structure 11A and the screw diameter of the screw structure 11B are different. That is, the thread of the mounting portion 33A of the cleaning container 3A meshes with the thread of the container mounting hole 26A, but does not mesh with the thread of the container mounting hole 26B. Similarly, the screw thread of the mounting portion 33B of the cleaning container 3B meshes with the screw thread of the container mounting hole 26B, but does not mesh with the screw thread of the container mounting hole 26A. As a result, in the work of attaching the cleaning containers 3A and 3B, it is possible to prevent a work error such as accidentally attaching another cleaning container.
  • the rinse port 1 is provided with the two cleaning containers 3A and 3B.
  • a liquid having a high cleaning effect is selected according to the analysis conditions or the type of sample.
  • an appropriate material is selected according to the type of cleaning liquid used.
  • the materials for the cleaning containers 3A and 3B are selected to have chemical resistance to the cleaning liquid used.
  • the material of the cleaning containers 3A and 3B is selected to have a weak adsorptivity to the sample.
  • the cleaning containers 3A and 3B can be individually removed from the rinse port body 2. Therefore, different kinds of materials can be used as the material of the cleaning container 3A and the material of the cleaning container 3B.
  • the material of the cleaning containers 3A and 3B for example, PEEK (polyetheretherketone), stainless steel, and ceramics can be used.
  • PEEK polyetheretherketone
  • stainless steel stainless steel
  • ceramics can be used as the material of the cleaning container 3B.
  • a combination in which PEEK is used as the material of the cleaning container 3A and stainless steel is used as the material of the cleaning container 3B is possible.
  • the cleaning containers of different materials are used as the cleaning containers 3A and 3B, different cleaning liquids can be used for each cleaning container.
  • the cleaning liquid in the cleaning container 3A needs to be replaced depending on the analysis condition or the type of sample, only the cleaning container 3A needs to be replaced. Further, when the cleaning container 3A needs to be replaced due to dirt, only the cleaning container 3A needs to be replaced.
  • PPS Polyphenylene Sulfide
  • the rinse port main body 2 receives the cleaning liquid overflowing the cleaning containers 3A and 3B, it is preferable that the rinse port main body 2 has excellent chemical resistance. From this viewpoint, a metal such as stainless steel may be used as the material of the rinse port body 2, but in the present embodiment, PPS is used from the viewpoint of workability.
  • two protrusions 31A and 31A are provided on the upper end of the cleaning container 3A, and two grooves are provided between the two protrusions 31A and 31A.
  • 32A and 32A are formed.
  • two protrusions 31B, 31B are provided on the upper end of the cleaning container 3B, and two grooves 32B, 32B are formed between the two protrusions 31B, 31B. ing.
  • the wrench 9 engages with the two grooves 32A, 32A. Similarly, the wrench 9 engages with the two grooves 32B and 32B. In FIG. 4, as an example, the wrench 9 is engaged with the two grooves 32B, 32B of the cleaning container 3B.
  • the operator can screw the cleaning container 3A or 3B onto the rinse port body 2 by rotating the wrench 9 in the XY plane. That is, by rotating the cleaning container 3A with the wrench 9, the screw structure 11A is fastened or released. Alternatively, the cleaning container 3B is rotated by the wrench 9, whereby the screw structure 11B is fastened or released.
  • the grooves 32A and 32B engaged with the wrench 9 are formed at the upper ends of the cleaning containers 3A and 3B.
  • the operator can perform the work of attaching and removing the wash containers 3A and 3B by engaging the wrench 9 with the upper ends of the wash containers 3A and 3B. Therefore, the workability is good.
  • the grooves 32A and 32B at the upper ends of the cleaning containers 3A and 3B also serve as channels for discharging the cleaning liquid when the cleaning liquid overflows. That is, the grooves 32A and 32B have a use as openings for discharging the cleaning liquid of a predetermined level or higher in the cleaning containers 3A and 3B.
  • the grooves 32A and 32B have both a use for engaging a tool and a use as a cleaning liquid flow path, and the number of parts is reduced.
  • the upper ends of the grooves 32A and 32B are arranged above the upper end of the rinse port body 2.
  • the workability is good when the operator engages and dismounts the cleaning containers 3A and 3B by engaging the wrench 9 with the upper ends of the cleaning containers 3A and 3B.
  • grooves 32A and 32A are formed at two locations on the upper end of the cleaning container 3A.
  • grooves 32B and 32B are formed at two locations on the upper end of the cleaning container 3B. That is, in the present embodiment, the two grooves 32A, 32A are provided at different positions in the circumferential direction with respect to the rotary shaft 35A (see FIG. 10). Similarly, in the present embodiment, two grooves 32B, 32B are provided at different positions in the circumferential direction with respect to rotary shaft 35B (see FIG. 13). As a result, the cleaning liquid overflows from the plurality of grooves, whereby a sufficient flow path for the cleaning liquid is secured.
  • the cleaning containers 3A and 3A are fixed by screwing, the positions of the grooves 32A and 32B in the circumferential direction are not fixed. Even when the positions of the grooves 32A, 32B are close to the wall surface of the main body upper portion 21, the grooves 32A, 32A and 32B, 32B are formed at two different positions in the circumferential direction, so that the flow path of the overflowing cleaning liquid is formed. Therefore, the cleaning liquid can be prevented from overflowing from the upper portion of the rinse port body 2.
  • FIG. 14 is a perspective view of the rinse port cover 4.
  • FIG. 15 is a plan view of the cover cap 45.
  • the rinse port cover 4 and the cover cap 45 do not have a vertical direction, in the following description, the rinse port cover 4 and the cover cap 45 are attached to the rinse port body 2, and the rinse port 1 is the autosampler. It is assumed that the vertical direction in the state of being attached to 7 is the vertical direction of the rinse port cover 4 and the cover cap 45.
  • the rinse port cover 4 has a substantially rectangular parallelepiped outer shape.
  • the lower portion of the rinse port cover 4 is open almost entirely.
  • FIG. 2 shows a state in which the rinse port cover 4 is attached to the upper portion of the rinse port body 2.
  • the lower opening of the rinse port cover 4 is connected to the upper opening of the upper portion 21 of the rinse port body 2.
  • the rinse port cover 4 covers the internal space 20 of the rinse port body 2 from above.
  • the cap insertion groove 41 is a groove having a circular shape in plan view.
  • the cap insertion groove 41 has a depth corresponding to the vertical thickness of the cover cap 45.
  • An opening 42 is provided at the center of the cap insertion groove 41.
  • the cover cap 45 has a circular shape in plan view.
  • the cover cap 45 can be attached to the cap insertion groove 41 of the rinse port cover 4.
  • the diameter of the cap insertion groove 41 is substantially the same as the diameter of the cover cap 45 or slightly smaller than the diameter of the cover cap 45. With this configuration, the cover cap 45 is held in the cap insertion groove 41 by pushing the cover cap 45 into the cap insertion groove 41.
  • PP polypropylene
  • PE polyethylene
  • an insertion hole 451 for the needle 73 is provided at the center of the cover cap 45.
  • the position of the insertion hole 451 overlaps with the opening 42 of the rinse port cover 4 in a plan view.
  • the needle 73 passes through the rinse port cover 4 via the insertion hole 451 and reaches the cleaning containers 3A, 3B housed in the rinse port 1.
  • the insertion hole 451 may be formed in the cover cap 45 before use, or may not be formed in the cover cap 45 before use. When the insertion hole 451 is not formed in the cover cap 45 before use, when the needle 73 first passes through the cover cap 45, the tip of the needle 73 pierces the cover cap 45 and the insertion hole 451 is formed.
  • the rinse port 1 is an example of a cleaning unit
  • the rinse port body 2 is an example of a unit body
  • the first supply port 24A and the second supply port 24B are examples of supply ports.
  • the screw structure 11A constituted by the screw thread formed on the outer periphery of the mounting portion 33A and the screw thread formed on the inner periphery of the container mounting hole 26A is the same as the screw structure of the present invention.
  • the screw structure 11B constituted by the screw thread formed on the outer circumference of the mounting portion 33B and the screw thread formed on the inner circumference of the container mounting hole 26B is an example of the screw structure in the present invention.
  • the wrench 9 in the above embodiment is an example of the tool in the present invention
  • the grooves 32A and 32B are examples of the engaging portion or the opening in the present invention. That is, the grooves 32A and 32B are an example of an engaging portion that can be engaged with a tool and an example of an opening for discharging the cleaning liquid at a predetermined level or higher.
  • the rotary shafts 35A and 35B are examples of the "vertical rotary shaft" in the present invention.
  • the configuration in which the rinse port 1 includes the two cleaning containers 3A and 3B has been described as an example, but the number of cleaning containers is not limited to this.
  • the number of cleaning containers accommodated in the rinse port 1 may be one, or may be three or more.
  • the screw structure in the present invention is not limited to the screw structures 11A and 11B in the above embodiment.
  • the screw structure may be a structure using bolts.
  • the cleaning containers 3A and 3B have been described by way of example of the structure in which they are attached to the rinse port 1 by the screw structures 11A and 11B. Not a thing.
  • the cleaning containers 3A and 3B may be detachably attached to the rinse port body 2 by another attachment structure.
  • two protrusions 31A and 31B are provided at the upper ends of the cleaning containers 3A and 3B, respectively, and two grooves 32A and 32B are provided respectively.
  • Three or more protrusions may be provided on the upper ends of the cleaning containers 3A and 3B, and three or more grooves may be formed accordingly.
  • the grooves 32A and 32B are provided as openings at the upper end of the cleaning container 3, but the opening is not limited to this, and a hole is provided at a predetermined height of the cleaning container 3 as an opening. May be.

Abstract

L'invention concerne un auto-échantillonneur comprenant : un orifice d'injection permettant de fournir un échantillon à analyser à un analyseur ; une aiguille permettant d'extraire un échantillon à analyser logé dans un flacon, et d'injecter l'échantillon à analyser dans l'orifice d'injection ; et une unité de nettoyage permettant de nettoyer l'aiguille. L'unité de nettoyage comprend : un récipient de nettoyage possédant un orifice d'alimentation et recevant un fluide de nettoyage fourni par l'intermédiaire de l'orifice d'alimentation, et dans lequel une aiguille nécessitant un nettoyage est insérée dans le fluide de nettoyage logé à l'intérieur de ce dernier ; et un corps d'unité possédant un espace permettant de loger le récipient de nettoyage et de recevoir un fluide de nettoyage ayant débordé du récipient de nettoyage, et auquel le récipient de nettoyage est fixé amovible.
PCT/JP2018/039394 2018-10-23 2018-10-23 Auto-échantillonneur WO2020084697A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/JP2018/039394 WO2020084697A1 (fr) 2018-10-23 2018-10-23 Auto-échantillonneur
JP2020551753A JP7136223B2 (ja) 2018-10-23 2018-10-23 オートサンプラ

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2018/039394 WO2020084697A1 (fr) 2018-10-23 2018-10-23 Auto-échantillonneur

Publications (1)

Publication Number Publication Date
WO2020084697A1 true WO2020084697A1 (fr) 2020-04-30

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Application Number Title Priority Date Filing Date
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JP (1) JP7136223B2 (fr)
WO (1) WO2020084697A1 (fr)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0527666U (ja) * 1991-09-19 1993-04-09 株式会社日立製作所 自動試料導入装置
JPH11329666A (ja) * 1998-05-15 1999-11-30 Ngk Spark Plug Co Ltd スパークプラグ
JP2004223352A (ja) * 2003-01-21 2004-08-12 Tosoh Corp 洗浄装置
JP2005000775A (ja) * 2003-06-10 2005-01-06 Nippon Pulse Motor Co Ltd ニードル洗浄装置
JP2006126016A (ja) * 2004-10-29 2006-05-18 Furuno Electric Co Ltd ノズル洗浄装置、及びそれを備える生化学分析装置
JP2007118273A (ja) * 2005-10-26 2007-05-17 Zebra Pen Corp 筆記具用嵌合構造
US20120227771A1 (en) * 2009-11-20 2012-09-13 Siemens Healthcare Diagnostics Inc. Apparatus, Systems, And Methods Adapted To Rinse And Dry Clinical Analyzer Sample Probes
JP2015014499A (ja) * 2013-07-04 2015-01-22 ダイハツ工業株式会社 水素−酸素結合装置
JP2015181432A (ja) * 2014-03-25 2015-10-22 グローブライド株式会社 ロッドクランプ及びそれに使用される頭部付き円筒ナット

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01209372A (ja) * 1988-02-18 1989-08-23 Toshiba Corp 自動化学分析装置の洗浄装置
JP4385935B2 (ja) 2004-12-02 2009-12-16 株式会社島津製作所 自動試料注入装置

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0527666U (ja) * 1991-09-19 1993-04-09 株式会社日立製作所 自動試料導入装置
JPH11329666A (ja) * 1998-05-15 1999-11-30 Ngk Spark Plug Co Ltd スパークプラグ
JP2004223352A (ja) * 2003-01-21 2004-08-12 Tosoh Corp 洗浄装置
JP2005000775A (ja) * 2003-06-10 2005-01-06 Nippon Pulse Motor Co Ltd ニードル洗浄装置
JP2006126016A (ja) * 2004-10-29 2006-05-18 Furuno Electric Co Ltd ノズル洗浄装置、及びそれを備える生化学分析装置
JP2007118273A (ja) * 2005-10-26 2007-05-17 Zebra Pen Corp 筆記具用嵌合構造
US20120227771A1 (en) * 2009-11-20 2012-09-13 Siemens Healthcare Diagnostics Inc. Apparatus, Systems, And Methods Adapted To Rinse And Dry Clinical Analyzer Sample Probes
JP2015014499A (ja) * 2013-07-04 2015-01-22 ダイハツ工業株式会社 水素−酸素結合装置
JP2015181432A (ja) * 2014-03-25 2015-10-22 グローブライド株式会社 ロッドクランプ及びそれに使用される頭部付き円筒ナット

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