JP6973486B2 - 送液装置及び液体クロマトグラフ - Google Patents
送液装置及び液体クロマトグラフ Download PDFInfo
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- JP6973486B2 JP6973486B2 JP2019528244A JP2019528244A JP6973486B2 JP 6973486 B2 JP6973486 B2 JP 6973486B2 JP 2019528244 A JP2019528244 A JP 2019528244A JP 2019528244 A JP2019528244 A JP 2019528244A JP 6973486 B2 JP6973486 B2 JP 6973486B2
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- 239000007788 liquid Substances 0.000 title claims description 65
- 239000000126 substance Substances 0.000 claims description 43
- 238000004458 analytical method Methods 0.000 claims description 36
- 239000000356 contaminant Substances 0.000 claims description 30
- 239000000945 filler Substances 0.000 claims description 25
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 12
- 238000002347 injection Methods 0.000 claims description 10
- 239000007924 injection Substances 0.000 claims description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- 125000000524 functional group Chemical group 0.000 claims description 8
- 229920000642 polymer Polymers 0.000 claims description 8
- 239000000741 silica gel Substances 0.000 claims description 8
- 229910002027 silica gel Inorganic materials 0.000 claims description 8
- 239000011148 porous material Substances 0.000 claims description 6
- 238000011144 upstream manufacturing Methods 0.000 claims description 6
- 239000000523 sample Substances 0.000 description 16
- 239000007787 solid Substances 0.000 description 7
- 239000000463 material Substances 0.000 description 5
- 239000003344 environmental pollutant Substances 0.000 description 3
- 231100000719 pollutant Toxicity 0.000 description 3
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 3
- 239000004810 polytetrafluoroethylene Substances 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000010206 sensitivity analysis Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- -1 polytetrafluoroethylene Polymers 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 229910021642 ultra pure water Inorganic materials 0.000 description 1
- 239000012498 ultrapure water Substances 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D19/00—Degasification of liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/326—Control of physical parameters of the fluid carrier of pressure or speed pumps
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
- G01N2030/342—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient fluid composition fixed during analysis
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- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Sampling And Sample Adjustment (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Description
2a,2b 送液ポンプ
4a,4a',4b 吸引用配管
6a,6a',6b 溶解物質除去フィルタ
8a,8b 移動相容器
10 ミキサ
12 分析流路
14 試料注入部
16 分析カラム
18 検出器
20,32 本体部
22,36 蓋部
24,38 突起
26,34,40 接続孔
28,42 充填剤
30,43,44 フィルタ
46 サクションフィルタ
Claims (6)
- 液体である移動相を収容する移動相容器の前記移動相に端部が浸漬された吸引用配管を介して前記移動相容器から前記移動相を吸引して送液する送液ポンプと、
前記吸引用配管の前記端部において前記移動相中の汚染物質を除去する多孔質材料からなるフィルタと、
前記移動相の流れる経路上における前記送液ポンプよりも上流の位置に設けられた空間内に充填され、前記多孔質材料からなるフィルタを通過した前記移動相中の溶解物質を吸着させる性質をもつ充填剤と、を備えた送液装置。 - 前記充填剤は前記多孔質材料からなるフィルタによって囲われた空間内に充填されている、請求項1に記載の送液装置。
- 前記充填剤が前記移動相の流れる経路に沿って直列に設けられた複数の空間内に充填されている、請求項1又は2に記載の送液装置。
- 前記複数の空間のそれぞれに充填されている前記充填剤は互いに異なる溶解物質を吸着させる性質を有する、請求項3に記載の送液装置。
- 前記充填剤は、活性炭、シリカゲル、ポリマー、表面に官能基が修飾されたシリカゲル又は表面に官能基が修飾されたポリマーのいずれかである、請求項1から4のいずれか一項に記載の送液装置。
- 分析流路と、
前記分析流路中において移動相を送液する請求項1から5のいずれか一項に記載の送液装置と、
前記分析流路中に試料を注入する試料注入部と、
前記分析流路上における前記試料注入部よりも下流の位置に設けられ、前記試料注入部により前記分析流路中に注入された試料を成分ごとに分離する分析カラムと、
前記分析流路上における前記分析カラムよりも下流の位置に設けられ、前記分析カラムで分離した試料成分を検出するための検出器と、を備えた液体クロマトグラフ。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP2017/024544 WO2019008683A1 (ja) | 2017-07-04 | 2017-07-04 | 送液装置及び液体クロマトグラフ |
Publications (2)
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JPWO2019008683A1 JPWO2019008683A1 (ja) | 2020-05-21 |
JP6973486B2 true JP6973486B2 (ja) | 2021-12-01 |
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JP2019528244A Active JP6973486B2 (ja) | 2017-07-04 | 2017-07-04 | 送液装置及び液体クロマトグラフ |
Country Status (4)
Country | Link |
---|---|
US (1) | US11143635B2 (ja) |
JP (1) | JP6973486B2 (ja) |
CN (1) | CN110709695B (ja) |
WO (1) | WO2019008683A1 (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7259870B2 (ja) * | 2019-01-11 | 2023-04-18 | 株式会社島津製作所 | 液体クロマトグラフに使用されるミキサおよび液体クロマトグラフ |
US20230010923A1 (en) * | 2019-11-22 | 2023-01-12 | Shimadzu Corporation | Pump unit and chromatograph |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09113494A (ja) * | 1995-10-24 | 1997-05-02 | Tosoh Corp | 分析試薬用溶液容器 |
US20050100477A1 (en) * | 2003-11-06 | 2005-05-12 | Alltech Associates, Inc. | Apparatus and method for removing gas prior to sample detection and/or analysis |
JP4241538B2 (ja) * | 2004-07-29 | 2009-03-18 | 株式会社島津製作所 | 液体クロマトグラフ用送液装置 |
CN2901306Y (zh) * | 2006-05-25 | 2007-05-16 | 中国药品生物制品检定所 | 一种用于高效液相色谱系统的流动相密闭环保装置 |
WO2008008897A2 (en) * | 2006-07-12 | 2008-01-17 | Steward Environmental Solutions, Llc | Method and system to remove agent from liquid phase |
JP5407801B2 (ja) * | 2009-11-24 | 2014-02-05 | 栗田工業株式会社 | イオン交換樹脂層の形成方法 |
JP2011085434A (ja) * | 2009-10-14 | 2011-04-28 | Tosoh Corp | 溶離液およびその製造方法 |
CN203490202U (zh) * | 2013-09-23 | 2014-03-19 | 王飞 | 一种高效液相色谱仪 |
CN205280673U (zh) | 2016-01-07 | 2016-06-01 | 刘广文 | 一种高效液相色谱仪 |
CN105606753B (zh) * | 2016-01-27 | 2018-08-14 | 中山大学 | 场辅助萃取-分离富集-色谱分析在线联用设备 |
CN205844283U (zh) * | 2016-08-05 | 2016-12-28 | 深圳出入境检验检疫局工业品检测技术中心 | 一种新型液相色谱用流动相盛放装置 |
-
2017
- 2017-07-04 WO PCT/JP2017/024544 patent/WO2019008683A1/ja active Application Filing
- 2017-07-04 CN CN201780091252.1A patent/CN110709695B/zh active Active
- 2017-07-04 US US16/621,369 patent/US11143635B2/en active Active
- 2017-07-04 JP JP2019528244A patent/JP6973486B2/ja active Active
Also Published As
Publication number | Publication date |
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CN110709695A (zh) | 2020-01-17 |
JPWO2019008683A1 (ja) | 2020-05-21 |
US20200166486A1 (en) | 2020-05-28 |
US11143635B2 (en) | 2021-10-12 |
WO2019008683A1 (ja) | 2019-01-10 |
CN110709695B (zh) | 2022-10-04 |
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