WO2020042106A1 - 一种消炎抗菌外用软膏 - Google Patents

一种消炎抗菌外用软膏 Download PDF

Info

Publication number
WO2020042106A1
WO2020042106A1 PCT/CN2018/103316 CN2018103316W WO2020042106A1 WO 2020042106 A1 WO2020042106 A1 WO 2020042106A1 CN 2018103316 W CN2018103316 W CN 2018103316W WO 2020042106 A1 WO2020042106 A1 WO 2020042106A1
Authority
WO
WIPO (PCT)
Prior art keywords
parts
extract
inflammatory
antibacterial
ointment
Prior art date
Application number
PCT/CN2018/103316
Other languages
English (en)
French (fr)
Inventor
吴克
Original Assignee
江苏奇力康皮肤药业有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 江苏奇力康皮肤药业有限公司 filed Critical 江苏奇力康皮肤药业有限公司
Priority to PCT/CN2018/103316 priority Critical patent/WO2020042106A1/zh
Publication of WO2020042106A1 publication Critical patent/WO2020042106A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/758—Zanthoxylum, e.g. pricklyash
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics

Definitions

  • the invention relates to a traditional Chinese medicine ointment. More specifically, the present invention relates to an anti-inflammatory antibacterial external ointment.
  • the existing anti-inflammatory and antibacterial topical ointments have the following disadvantages: (1) due to the complexity of traditional Chinese medicine ingredients and in-depth research on the effective ingredients, antibacterial mechanisms, and compound medications of traditional Chinese medicines, the existing anti-inflammatory and antibacterial traditional Chinese medicines have bacteriostatic and bactericidal efficiency Low, short duration of efficacy, poor stability and other issues; (2) only the efficacy of traditional Chinese medicine is considered when formulating the plaster, and its toxicity and irritation are ignored, but it will aggravate the discomfort of the patient; (3) traditional traditional Chinese medicine plaster is more Hemp oil is used for the extraction of traditional Chinese medicine ingredients, which is easy to destroy the effective ingredients or incomplete extraction of the active ingredients due to high temperature; (4) hormones are added to some drugs, which are often dependent and even have other harms to the body.
  • Another object of the present invention is to provide an anti-inflammatory antibacterial external ointment, which has a mild, significant and long-lasting anti-inflammatory antibacterial effect, and is applied to skin infections such as pustules, body trauma infections, eczema combined infections, wounds and pus, etc. Can form a safe film, effectively antibacterial and anti-inflammatory, and promote healing of the sore surface.
  • an anti-inflammatory antibacterial external ointment which includes component A and auxiliary component B;
  • the component A includes:
  • Ginkgo biloba extract 10-20 servings
  • Cassia extract has an inhibitory effect on bacteria such as Staphylococcus, diphtheria, typhoid, paratyphoid, and E. coli, as well as Xanthomonas and microsporum; Ginkgo biloba extract is effective against pseudomonas and large intestine The inhibitory effect of Bacillus spp. Is remarkable; the extract of Zanthoxylum bungeum has obvious inhibitory effect on spoilage bacteria and pathogenic bacteria; the golden fragrant wood extract has broad-spectrum antibacterial activity, and the smell is fragrant, which can increase patients' acceptance of the plaster.
  • Konjac glucoside can play a certain bactericidal effect on the growth of a variety of bacteria and fungi, it has significant antipruritic effect, and it is antibacterial in traditional Chinese medicine composed of cassia seed extract, ginkgo fruit extract, pepper extract and golden fragrant wood extract Adding a certain proportion of konjac glucoside to the agent can significantly enhance the antibacterial performance of the plaster by changing the cell's selective permeability and selective chelation of metal ions that play a key role in the microorganisms.
  • the oligochitosan can enter the inside of the bacteria body and increase the antibacterial activity of the plaster.
  • the cross-linked compound of konjac glucoside and oligochitosan can improve the film-forming properties of the ointment and the durability of the medicinal effect.
  • the auxiliary component B includes:
  • the addition of a suitable ratio of zein, glycerin and beeswax can significantly improve the mechanical properties, moisture retention and breathability of the thin film formed after the ointment is applied to the skin, improve the steady-state slow-release performance of traditional Chinese medicine ingredients, and the effective ingredients of the skin. Absorption.
  • the pH of the ointment is 5.2-5.8, which helps the skin to absorb the active ingredients of Chinese medicine.
  • the relative molecular weight of the konjac glucoside is 150KDa to 300KDa, and under this condition, the konjac glucoside has a strong antibacterial activity.
  • the relative molecular weight of the oligochitosan is from 7KDa to 12KDa.
  • the oligochitosan is at this molecular weight, it can cause more damage to the cell surface and increase the antibacterial activity.
  • the Cassia seed extract, the Ginkgo biloba fruit extract and the Jinxiang wood extract are all methanol extracts, and the methanol extract of the Cassia seed, Ginkgo biloba fruit and Jinxiang wood has an obvious antibacterial and anti-inflammatory effect.
  • the peppercorn extract is a mixed solvent extract of methanol and acetone, and the effective component of the peppercorn extract extracted from the methanol and acetone mixed solvent has an obvious antibacterial and anti-inflammatory effect.
  • the ratio of methanol to acetone in the mixed solvent is 3: 1, and the extraction rate of effective components of Zanthoxylum bungeumum can be significantly improved under this ratio.
  • the reasonable compatibility of Cassia seed, Ginkgo biloba fruit, Zanthoxylum, Jinxiang wood, Konjac glucoside and oligochitosan can produce a strong and lasting anti-inflammatory and antibacterial effect, and can significantly reduce the dosage .
  • zein, glycerin and beeswax can significantly improve the steady-state slow-release performance of Chinese medicine ingredients and the skin's absorption of active ingredients.
  • the present invention replaces the traditional sesame oil extraction method, and uses different organic solvent processes for extraction according to the different properties of Chinese herbal medicines, which not only ensures sufficient extraction of effective ingredients, but also avoids excessive impurities in traditional Chinese medicine pastes caused by excessive extraction temperatures. Poor effect.
  • An anti-inflammatory and antibacterial external ointment which includes component A and auxiliary component B;
  • the component A includes: 15 parts of Cassia Seed Extract; 10 parts of Ginkgo Biloba Extract; 5 parts of Zanthoxylum Extract; 2 parts of Goldenwood Extract; 2 parts of Konjac Glucoside; 1 serving of sugar.
  • the auxiliary component B includes: 1 part of zein, 1 part of glycerin, and 0.3 part of beeswax.
  • the pH of the ointment is 5.2
  • the relative molecular weight of the konjac glucoside is 150KDa
  • the relative molecular weight of the oligochitosan is 7KDa.
  • the Cassia extract, the Ginkgo biloba extract, and the Jinxiang wood extract are all methanol extracts;
  • the peppercorn extract is a mixed solvent extract of methanol and acetone, and the ratio of methanol and acetone in the mixed solvent is It's 3: 1.
  • An anti-inflammatory and antibacterial external ointment which includes component A and auxiliary component B;
  • the component A includes: 30 parts of Cassia seed extract; 20 parts of ginkgo fruit extract; 9 parts of pepper extract; 6 parts of golden fragrant wood extract; 7 parts of konjac glucoside polysaccharide; 3 servings of sugar.
  • the auxiliary component B includes: 3 parts of zein, 3 parts of glycerin, and 1 part of beeswax.
  • the pH of the ointment is 5.8, the relative molecular weight of the konjac glucoside is 300KDa, and the relative molecular weight of the oligochitosan is 12KDa.
  • the Cassia extract, the Ginkgo biloba extract, and the Jinxiang wood extract are all methanol extracts;
  • the peppercorn extract is a mixed solvent extract of methanol and acetone, and the ratio of methanol and acetone in the mixed solvent is It's 3: 1.
  • An anti-inflammatory and antibacterial external ointment which includes component A and auxiliary component B;
  • the component A includes: 20 parts of Cassia seed extract; 15 parts of ginkgo fruit extract; 7 parts of peppercorn extract; 4 parts of golden fragrant wood extract; 4 parts of konjac glucoside; and oligochitosan 2 servings of sugar.
  • the auxiliary component B includes: 2 parts of zein, 2 parts of glycerin, and 0.6 parts of beeswax.
  • the pH of the ointment is 5.5
  • the relative molecular weight of the konjac glucoside is 210 KDa
  • the relative molecular weight of the oligochitosan is 10 KDa.
  • the Cassia extract, the Ginkgo biloba extract, and the Jinxiang wood extract are all methanol extracts;
  • the peppercorn extract is a mixed solvent extract of methanol and acetone, and the ratio of methanol and acetone in the mixed solvent is It's 3: 1.
  • An anti-inflammatory and antibacterial external ointment which includes component A and auxiliary component B;
  • the component A includes: 17 parts of Cassia Seed Extract; 12 parts of Ginkgo Biloba Extract; 8 parts of Zanthoxylum Extract; 3 parts of Goldenwood Extract; 6 parts of Konjac Glucan; 3 servings of sugar.
  • the auxiliary component B includes: 2 parts of zein, 2 parts of glycerin, and 0.9 parts of beeswax.
  • the pH of the ointment is 5.3
  • the relative molecular weight of the konjac glucoside is 170KDa
  • the relative molecular weight of the oligochitosan is 9KDa.
  • the Cassia extract, the Ginkgo biloba extract, and the Jinxiang wood extract are all methanol extracts;
  • the peppercorn extract is a mixed solvent extract of methanol and acetone, and the ratio of methanol and acetone in the mixed solvent is It's 3: 1.
  • An anti-inflammatory and antibacterial external ointment which includes component A and auxiliary component B;
  • the component A includes: 27 parts of Cassia seed extract; 18 parts of ginkgo fruit extract; 6 parts of pepper extract; 5 parts of golden fragrant wood extract; 3 parts of konjac glucoside; and oligochitosan 1 serving of sugar.
  • the auxiliary component B includes: 1 part of zein, 3 parts of glycerin, and 0.5 parts of beeswax.
  • the pH of the ointment is 5.6
  • the relative molecular weight of the konjac glucoside is 250KDa
  • the relative molecular weight of the oligochitosan is 10KDa.
  • the Cassia extract, the Ginkgo biloba extract, and the Jinxiang wood extract are all methanol extracts;
  • the peppercorn extract is a mixed solvent extract of methanol and acetone, and the ratio of methanol and acetone in the mixed solvent is It's 3: 1.
  • 24 rat skin trauma models were selected and randomly divided into 8 groups.
  • the anti-inflammatory and antibacterial external ointments prepared in the above examples and comparative examples were used for administration 3 times a day to observe the general changes of the wounds and calculate the wound healing rate.
  • wound healing rate (original wound area-unhealed area) * 100% / original wound area. See Table 1 for specific results.
  • Comparative Example 1 did not add auxiliary component B when preparing the anti-inflammatory antibacterial external ointment, and the film formed by applying the ointment to the skin had poor property stability, which affected the effect of the repair and treatment of the active ingredients of Chinese medicine carried by the ointment.
  • Comparative Example 3 Compared with Example 3, in the preparation of anti-inflammatory antibacterial external ointment, Comparative Example 3 only used a single extraction solvent, methanol, to extract the active ingredients in the peppercorns, and the antibacterial and anti-inflammatory effect of the ointment was also reduced. This indicates that the single extraction solvent, methanol, cannot fully extract the peppercorns. Active ingredients in.
  • the anti-inflammatory and antibacterial external ointment provided by the present invention has a mild, significant and long-lasting anti-inflammatory and antibacterial effect. It can be applied to wounds such as pustules, body trauma infections, eczema combined infections, wounds and pus, etc. Film, effective antibacterial and anti-inflammatory, and promote healing of the sore surface.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

一种消炎抗菌外用软膏，包括组份A和辅助组份B；按重量份计，所述组份A包括：决明子提取物15-30份，银杏果提取物10-20份，花椒提取物5-9份，金香木提取物2-6份，魔芋葡苷聚糖2-7份，低聚壳聚糖1-3份；所述辅助组份B包括：玉米醇溶蛋白1-3份，甘油1-3份，蜂蜡0.3-1份。该消炎抗菌外用软膏具有温和、显著和持久的消炎抗菌效果，涂覆于皮肤感染例如脓包、体表外伤感染、湿疹合并感染、伤口流水化脓等创面，可形成一层安全的薄膜，有效抗菌消炎，促进疮面愈合。

Description

一种消炎抗菌外用软膏 技术领域
本发明涉及一种中药膏剂。更具体地说，本发明涉及一种消炎抗菌外用软膏。
背景技术
随着西药抗菌药大举进入中国市场，传统的中药抗菌作用淡出了人们的视野。但近些年，由于“滥用抗菌药”导致的抗菌药耐药性和一些不可避免的不良反应等问题日益突出。这令不少专家和医药工作者开始反思抗菌药物的研发和应用思路，并把目光又重新落到了中药方面，希望能从这里找到新的突破点。
但现有的消炎抗菌外用药膏具有有如下缺点：(1)由于中药成分复杂，并且对中药有效成分、抗菌机制和复方用药方面的研究还不深入，导致现有消炎抗菌中药存在抑菌杀菌效率低下，药效持续时间短，稳定性差等问题；(2)配制膏剂时仅考虑到中药的功效，而忽视了其毒性和刺激性，反而会加重患者的不适现象；(3)传统中药膏剂多以麻油进行中药成分的提取，易因温度过高破坏药材内的有效成分或有效成分提取不完整；(4)有的药物中添加有激素，常用有依赖性，甚至会对身体有其他危害。
发明内容
作为各种广泛且细致的研究和实验的结果，本发明的发明人已经发现，决明子、银杏果、花椒、金香木、魔芋葡苷聚糖以及低聚壳聚糖的合理配伍使用，可显著降低用药剂量，并且消炎抗菌效果显著持久。基于这种发现，完成了本发明。
本发明的一个目的是解决至少上述问题和/或缺陷，并提供至少后面将说明的优点。
本发明还有一个目的是提供一种消炎抗菌外用软膏，其具有温和、显著和持久的消炎抗菌效果，涂覆于皮肤感染例如脓包、体表外伤感染、湿疹合并感染、伤口流水化脓等创面，可形成一层安全的薄膜，有效抗菌消炎，促进疮面愈合。
为了实现根据本发明的这些目的和其它优点，提供了一种消炎抗菌外用软膏，其包括组份A和辅助组份B；
按重量份计，所述组份A包括：
决明子提取物           15-30份；
银杏果提取物           10-20份；
花椒提取物             5-9份；
金香木提取物           2-6份；
魔芋葡苷聚糖           2-7份；
低聚壳聚糖             1-3份。
在上述中药组份A配方中，决明子提取物、银杏果提取物、花椒提取物、金香木提取物、魔芋葡苷聚糖、低聚壳聚糖等几种天然药物联合用药，可降低药物用量，提升药物的抗菌消炎作用，促进皮肤创面恢复。
其中，决明子提取物对葡萄球菌、白喉杆菌、伤寒杆菌、副伤寒杆菌、大肠杆菌等细菌，以及许兰黄癣菌和小孢子菌均有抑制作用；银杏果提取物对假单孢菌及大肠杆菌的抑制效果显著；花椒提取物对腐败菌和致病菌具有明显的抑制效果；金香木提取物具有广谱抗菌活性，且气味芳香，可增加患者对膏药的接受程度。
魔芋葡苷聚糖对多种细菌和真菌的生长都能起到一定的杀菌作用，止痒作用显著，并且在决明子提取物、银杏果提取物、花椒提取物和金香木提取物组成的中药抗菌剂中添加一定比例的魔芋葡苷聚糖，通过改变细胞的选择通透性和选择性的鳌合对微生物起关键作用的金属离子，可显著增强膏药的抗菌性能。低聚壳聚糖可进入菌体内部，增加膏药的抑菌活性。此外，魔芋葡苷聚糖和低聚壳聚糖交联复配可提高软膏的成膜性和药效发挥的持久性。
优选的是，其中，按重量份计，所述辅助组份B包括：
玉米醇溶蛋白           1～3份；
甘油                   1～3份；
蜂蜡                   0.3～1份。
其中，合适配比玉米醇溶蛋白、甘油和蜂蜡的添加可显著提高软膏涂抹于皮肤后形成的薄膜的力学性能、保湿性和透气性能，提高中药成分稳态缓释性能，以及皮肤对有效成分的吸收。
优选的是，其中，所述软膏的PH为5.2-5.8，有助于皮肤对中药有效成分的吸收。
优选的是，其中，所述魔芋葡苷聚糖的相对分子量为150KDa～300KDa，在此条件下，魔芋葡苷聚糖具有较强的抑菌活性。
优选的是，其中，所述低聚壳聚糖的相对分子量为7KDa～12KDa，当低聚壳聚糖在此分子量下，可对细胞表面造成更多的损害，增加抑菌活性。
优选的是，其中，所述决明子提取物、所述银杏果提取物和所述金香木提取物均为甲醇提取物，所述决明子、银杏果和金香木的甲醇提取物的抗菌消炎效果明显。
优选的是，其中，所述花椒提取物为甲醇和丙酮的混合溶剂提取物，由甲醇和丙酮混合溶剂提取出的花椒的有效成分抗菌消炎效果明显。
优选的是，其中，所述混合溶剂中甲醇和丙酮比例为3:1，在此配比下可显著提升对花椒有效成分的提取率。
本发明至少包括以下有益效果：
在本发明中药膏剂配方中，决明子、银杏果、花椒、金香木、魔芋葡苷聚糖以及低聚壳聚糖的合理配伍使用，可产生强而持久的消炎抗菌作用，并且可以显著降低用药剂量。
此外，合适配比玉米醇溶蛋白、甘油和蜂蜡的添加可显著提高中药成分稳态缓释性能，以及皮肤对有效成分的吸收。
此外，本发明替代传统的麻油提取方法，根据中草药的不同性质采用不同的有机溶剂工艺进行提取，既保证了有效成分的充分提取，又避免的提取温度过高而造成的中药膏剂杂质多，药效差。
本发明的其它优点、目标和特征将部分通过下面的说明体现，部分还将通过对本发明的研究和实践而为本领域的技术人员所理解。
具体实施方式
下面结合具体实施例对本发明做进一步的详细说明，以令本领域技术人员参照说明书文字能够据以实施。
应当理解，本文所使用的诸如“具有”、“包含”以及“包括”术语并不配出一个或多个其它元件或其组合的存在或添加。
<实例1>
一种消炎抗菌外用软膏，其包括组份A和辅助组份B；
按重量份计，所述组份A包括：决明子提取物15份；银杏果提取物10份；花椒提取物5份；金香木提取物2份；魔芋葡苷聚糖2份；低聚壳聚糖1份。
按重量份计，所述辅助组份B包括：玉米醇溶蛋白1份；甘油1份；蜂蜡0.3份。
其中，所述软膏的PH为5.2，所述魔芋葡苷聚糖的相对分子量为150KDa，所述低聚壳聚糖的相对分子量为7KDa。
其中，所述决明子提取物、所述银杏提取物和所述金香木提取物均为甲醇提取物；所述花椒提取物为甲醇和丙酮的混合溶剂提取物，所述混合溶剂中甲醇和丙酮比例为3:1。
<实例2>
一种消炎抗菌外用软膏，其包括组份A和辅助组份B；
按重量份计，所述组份A包括：决明子提取物30份；银杏果提取物20份；花椒提取物9份；金香木提取物6份；魔芋葡苷聚糖7份；低聚壳聚糖3份。
按重量份计，所述辅助组份B包括：玉米醇溶蛋白3份；甘油3份；蜂蜡1份。
其中，所述软膏的PH为5.8，所述魔芋葡苷聚糖的相对分子量为300KDa，所述低聚壳聚糖的相对分子量为12KDa。
其中，所述决明子提取物、所述银杏提取物和所述金香木提取物均为甲醇提取物；所述花椒提取物为甲醇和丙酮的混合溶剂提取物，所述混合溶剂 中甲醇和丙酮比例为3:1。
<实例3>
一种消炎抗菌外用软膏，其包括组份A和辅助组份B；
按重量份计，所述组份A包括：决明子提取物20份；银杏果提取物15份；花椒提取物7份；金香木提取物4份；魔芋葡苷聚糖4份；低聚壳聚糖2份。
按重量份计，所述辅助组份B包括：玉米醇溶蛋白2份；甘油2份；蜂蜡0.6份。
其中，所述软膏的PH为5.5，所述魔芋葡苷聚糖的相对分子量为210KDa，所述低聚壳聚糖的相对分子量为10KDa。
其中，所述决明子提取物、所述银杏提取物和所述金香木提取物均为甲醇提取物；所述花椒提取物为甲醇和丙酮的混合溶剂提取物，所述混合溶剂中甲醇和丙酮比例为3:1。
<实例4>
一种消炎抗菌外用软膏，其包括组份A和辅助组份B；
按重量份计，所述组份A包括：决明子提取物17份；银杏果提取物12份；花椒提取物8份；金香木提取物3份；魔芋葡苷聚糖6份；低聚壳聚糖3份。
按重量份计，所述辅助组份B包括：玉米醇溶蛋白2份；甘油2份；蜂蜡0.9份。
其中，所述软膏的PH为5.3，所述魔芋葡苷聚糖的相对分子量为170KDa，所述低聚壳聚糖的相对分子量为9KDa。
其中，所述决明子提取物、所述银杏提取物和所述金香木提取物均为甲醇提取物；所述花椒提取物为甲醇和丙酮的混合溶剂提取物，所述混合溶剂中甲醇和丙酮比例为3:1。
<实例5>
一种消炎抗菌外用软膏，其包括组份A和辅助组份B；
按重量份计，所述组份A包括：决明子提取物27份；银杏果提取物18份；花椒提取物6份；金香木提取物5份；魔芋葡苷聚糖3份；低聚壳聚 糖1份。
按重量份计，所述辅助组份B包括：玉米醇溶蛋白1份；甘油3份；蜂蜡0.5份。
其中，所述软膏的PH为5.6，所述魔芋葡苷聚糖的相对分子量为250KDa，所述低聚壳聚糖的相对分子量为10KDa。
其中，所述决明子提取物、所述银杏提取物和所述金香木提取物均为甲醇提取物；所述花椒提取物为甲醇和丙酮的混合溶剂提取物，所述混合溶剂中甲醇和丙酮比例为3:1。
为了说明本发明的效果，发明人提供比较实验如下：
<比较例1>
在制备消炎抗菌外用软膏时，不添加辅助组份B，其余参数与实例1中的完全相同，工艺过程也完全相同。
<比较例2>
在制备消炎抗菌外用软膏时，不添加低聚壳聚糖，其余参数与实例2中的完全相同，工艺过程也完全相同。
<比较例3>
在制备消炎抗菌外用软膏时，仅采用单一提取溶剂甲醇提取花椒中的有效成分，其余参数与实例3中的完全相同，工艺过程也完全相同。
分别采用上述实例及比较例制备得到的消炎抗菌外用软膏，对大鼠皮肤创伤模型进行治疗试验：
选取24只大鼠皮肤创伤模型，随机分成8组，分别采用上述实例及比较例制备的消炎抗菌外用软膏给药，每天给药3次，观察创面的大体改变，并计算创面愈合率，
其中，创面愈合情况率的计算方法：采用透明膜描记判断创面愈合的情况。具体公示为：创面愈合率＝(原始创面面积-未愈合面积)*100％/原始创面面积。具体结果参见表1。
表1各实例及比较例对大鼠皮肤创伤模型的治疗结果
Figure PCTCN2018103316-appb-000001
比较例1与实例相比，在制备消炎抗菌外用软膏时，不添加辅助组份B，药膏涂敷于皮肤形成的薄膜性质稳定性差，影响了了其承载的中药有效成分的修复治疗效果。
比较例2与实例相比，在制备消炎抗菌外用软膏时，不添加低聚壳聚糖，药膏的抗菌消炎效果较差，皮肤恢复时间变长。
比较例3与实例相比，在制备消炎抗菌外用软膏时，仅采用单一提取溶剂甲醇提取花椒中的有效成分，药膏的抗菌消炎效果也有所降低，这说明仅采用单一提取溶剂甲醇不能充分提取花椒中的有效成分。
可见，本发明提供的消炎抗菌外用软膏，具有温和、显著和持久的消炎抗菌效果，涂覆于皮肤感染例如脓包、体表外伤感染、湿疹合并感染、伤口流水化脓等创面，可形成一层安全的薄膜，有效抗菌消炎，促进疮面愈合。
尽管本发明的实施方案已公开如上，但其并不仅仅限于说明书和实施方式中所列运用。它完全可以被适用于各种适合本发明的领域。对于熟悉本领域的人员而言，可容易地实现另外的修改。因此在不背离权利要求及等同范围所限定的一般概念下，本发明并不限于特定的细节和这里示出与描述的实施例。

Claims (8)

  1. 一种消炎抗菌外用软膏，其特征在于，包括组份A和辅助组份B；
    按重量份计，所述组份A包括：
    Figure PCTCN2018103316-appb-100001
  2. 如权利要求1所述的消炎抗菌外用软膏，其特征在于，
    按重量份计，所述辅助组份B包括：
    玉米醇溶蛋白            1～3份；
    甘油                   1～3份；
    蜂蜡                   0.3～1份。
  3. 如权利要求1所述的消炎抗菌外用软膏，其特征在于，所述软膏的PH为5.2-5.8。
  4. 如权利要求1所述的消炎抗菌外用软膏，其特征在于，所述魔芋葡苷聚糖的相对分子量为150KDa～300KDa。
  5. 如权利要求1所述的消炎抗菌外用软膏，其特征在于，所述低聚壳聚糖的相对分子量为7KDa～12KDa。
  6. 如权利要求1所述的消炎抗菌外用软膏，其特征在于，所述决明子提取物、所述银杏果提取物和所述金香木提取物均为甲醇提取物。
  7. 如权利要求1所述的消炎抗菌外用软膏，其特征在于，所述花椒提取物为甲醇和丙酮的混合溶剂提取物。
  8. 如权利要求7所述的消炎抗菌外用软膏，其特征在于，所述混合溶剂中甲醇和丙酮比例为3:1。
PCT/CN2018/103316 2018-08-30 2018-08-30 一种消炎抗菌外用软膏 WO2020042106A1 (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2018/103316 WO2020042106A1 (zh) 2018-08-30 2018-08-30 一种消炎抗菌外用软膏

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2018/103316 WO2020042106A1 (zh) 2018-08-30 2018-08-30 一种消炎抗菌外用软膏

Publications (1)

Publication Number Publication Date
WO2020042106A1 true WO2020042106A1 (zh) 2020-03-05

Family

ID=69643358

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2018/103316 WO2020042106A1 (zh) 2018-08-30 2018-08-30 一种消炎抗菌外用软膏

Country Status (1)

Country Link
WO (1) WO2020042106A1 (zh)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104610757A (zh) * 2015-01-15 2015-05-13 安徽巢湖南方膜业有限责任公司 一种可降解的谷类醇溶蛋白-壳聚糖复合性果蔬包装膜
CN107362067A (zh) * 2017-08-16 2017-11-21 佛山市三水区嘉华化学研究院（普通合伙） 一种清洁抑菌免洗喷雾

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104610757A (zh) * 2015-01-15 2015-05-13 安徽巢湖南方膜业有限责任公司 一种可降解的谷类醇溶蛋白-壳聚糖复合性果蔬包装膜
CN107362067A (zh) * 2017-08-16 2017-11-21 佛山市三水区嘉华化学研究院（普通合伙） 一种清洁抑菌免洗喷雾

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MENG, QINGREN: "Non-official translation: Common Traditional Chinese Medicines with Bactericidal and Bacteriostatic Effects", STUDY JOURNAL OF TRADITIONAL CHINESE MEDICINE, no. 1, 28 February 1988 (1988-02-28), pages 33 *
REN, SHUNCHENG ET AL.: "Effects of 30 Kinds of Chinese Herbs on Bacteria in Food", JOURNAL OF ANHUI AGRICULTURAL SCIENCES, vol. 38, no. 14, 20 May 2010 (2010-05-20), pages 7529-7531 - 7556 *

Similar Documents

Publication Publication Date Title
CN111202822A (zh) 一种妇科外用抗菌喷剂及其制备方法
CN105055642A (zh) 一种复方胍类消毒剂及其制备方法
CN107582691B (zh) 复方黄柏液涂剂漱口凝胶
CN111803624A (zh) 一种含有转移因子的皮肤抗菌凝胶制剂和制备方法
CN108451799A (zh) 一种洗手液及其制备方法
WO2020042106A1 (zh) 一种消炎抗菌外用软膏
CN102178924A (zh) 一种治疗脚气的复方中药溶液及其制备方法
CN105560891A (zh) 一种含有冰片的中药滴眼剂及其制备方法
CN106236807B (zh) 防治流感病毒组合物和中药复方口腔速溶膜制剂
CN103933446A (zh) 高良姜提取物在治疗脚癣和手癣的用途及其制备方法
CN103110734B (zh) 一种治疗妇科炎症的中药组合物及其制备方法
CN105943718B (zh) 一种沉香复方中药组合物及其制备方法、应用
CN108066754B (zh) 一种用于皮肤创面脱痂的菠萝蛋白酶组合物及其制备方法
CN105709272A (zh) 一种用于创面治疗的新型生物抗菌敷料
CN103845463B (zh) 治疗马骨关节炎性肿胀的中药透皮剂及其制备方法
CN105079305A (zh) 一种抗菌消炎外用中药复方凝胶剂及其制备方法
CN103585330B (zh) 一种用于皮肤真菌感染的中药组合物及其制备方法
CN102475774A (zh) 消炎止痛外敷药膏
CN104069410A (zh) 一种治疗脚气的药液
CN112472740B (zh) 用于制备防治奶牛乳房炎的中草药复方制剂及其应用
CN103110737B (zh) 一种治疗妇科炎症的中药组合物及其制备方法
CN103705563A (zh) 一种治疗感冒的中西药组合颗粒
CN100411637C (zh) 一种治疗乳房炎的中兽药及其制备方法
CN107802799A (zh) 一种医用消毒液
CN109248255A (zh) 蜂胶滴剂口腔溃疡专用

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18931505

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18931505

Country of ref document: EP

Kind code of ref document: A1