WO2020040165A1 - Ligne de transport de porte-échantillon et système d'automatisation d'inspection d'échantillons - Google Patents

Ligne de transport de porte-échantillon et système d'automatisation d'inspection d'échantillons Download PDF

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Publication number
WO2020040165A1
WO2020040165A1 PCT/JP2019/032541 JP2019032541W WO2020040165A1 WO 2020040165 A1 WO2020040165 A1 WO 2020040165A1 JP 2019032541 W JP2019032541 W JP 2019032541W WO 2020040165 A1 WO2020040165 A1 WO 2020040165A1
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WO
WIPO (PCT)
Prior art keywords
sample holder
sample
line
holder
inclined guide
Prior art date
Application number
PCT/JP2019/032541
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English (en)
Japanese (ja)
Inventor
一真 田村
神原　克宏
正史 遠藤
Original Assignee
株式会社日立ハイテクノロジーズ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社日立ハイテクノロジーズ filed Critical 株式会社日立ハイテクノロジーズ
Priority to JP2020538417A priority Critical patent/JP7163394B2/ja
Priority to CN201980052602.2A priority patent/CN112534272A/zh
Publication of WO2020040165A1 publication Critical patent/WO2020040165A1/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system

Definitions

  • the present invention relates to a sample holder transport line provided in a sample test automation system, and particularly to a mechanism for changing the transport direction of a sample holder.
  • samples such as blood and urine provided by patients are analyzed by analyzers for clinical tests.
  • preprocessing such as centrifugation, opening, and dispensing is performed on the sample, and the sample after the preprocessing is transported to the analyzer.
  • a sample holder capable of mounting a single sample container containing a sample is used for transporting the sample in the sample test automation system. The direction of the holder is changed.
  • Patent Document 1 discloses a transfer direction changing device including a direction change mechanism that transfers a test tube holder corresponding to a sample holder between two transfer paths that are different in transfer direction and are parallel at a predetermined interval. I have.
  • the direction changing mechanism disclosed in Patent Document 1 is an apparatus that opens and closes a transfer path by operating a cylinder, and performs a test between two transfer paths by using a rotating body with a magnet that attracts a holder engaging / disconnecting rod or a test tube holder that is rotated by a motor. Deliver the tube holder.
  • Patent Literature 1 since the holder engaging and disengaging rod rotated by the motor and the rotating body with the magnet are arranged between the two transport paths, it is necessary to secure a space for them. In addition, since a driving mechanism such as an actuator for driving the direction changing mechanism is required, the cost of the apparatus is increased and the control is complicated.
  • an object of the present invention is to provide a sample holder transfer line capable of transferring a sample holder between transfer lines having different transfer directions without using a new drive mechanism, and a sample test automation system including the same. .
  • the present invention provides a first transport line that transports a sample holder in a first direction, and a second transport line that transports the sample holder in a second direction that is different from the first direction.
  • the apparatus further includes an inclined guide that is arranged to be inclined with respect to the first transport line, and when the sample holder contacts the inclined guide, the inclined guide is pushed out by the transport force of the first transport line. As the specimen holder moves along the inclined guide, the inclined guide returns to its original state, so that the specimen holder passes through the passage opening and Characterized in that it is transferred to the second conveying line.
  • the present invention is a sample test automation system for performing pre-processing on a sample, wherein the system is provided with the sample holder transport line.
  • a sample holder transfer line capable of transferring a sample holder between transfer lines having different transfer directions without using a new drive mechanism, and a sample test automation system including the same.
  • FIG. 3 is a diagram illustrating a turn mechanism according to the first embodiment.
  • FIG. 5 is a diagram illustrating delivery of a sample holder in an acute angle direction by the turn mechanism according to the first embodiment.
  • FIG. 9 is a diagram illustrating a turn mechanism according to a second embodiment.
  • FIG. 13 is a diagram illustrating a turn mechanism according to a third embodiment.
  • sample test automation system 1 When a sample container containing a sample such as blood or urine is loaded, the sample test automation system 1 performs preprocessing such as centrifugation, opening, and dispensing, and transports the preprocessed sample to the analyzer 5.
  • the system includes a pre-processing system 3, a sample transfer device 2, and a holder transport system 4.
  • the sample test automation system 1 also collects samples after analysis.
  • the pre-processing system 3 mounts the sample container loaded by the operator on the sample holder, and conveys the sample holder on which the sample container is mounted to each pre-processing unit by a conveyance device such as a belt conveyor.
  • a conveyance device such as a belt conveyor.
  • This is a system for performing pre-processing.
  • One sample container is mounted on the sample holder of the present embodiment.
  • the pretreated sample container is transported to the holder transport system 4 while being mounted on the sample holder.
  • the holder transport system 4 is a system for connecting between the preprocessing system 3 and the sample transfer device 2, and is connected to a plurality of sample transfer devices 2 according to a layout in the sample test automation system 1.
  • the sample holder on which the sample container is mounted is transferred to the sample transfer device 2 via the holder transfer system 4.
  • the sample transfer device 2 transfers the sample container mounted on the sample holder to a sample rack on which a plurality of sample containers are mounted. For example, five sample containers are mounted on the sample rack.
  • the sample rack on which the plurality of sample containers have been transferred is transported to the analyzer 5, and the analyzer 5 executes an analysis process.
  • the sample transfer device 2 of the present embodiment has a sample buffer line capable of holding a plurality of transported sample holders in case of an abnormal stop in the analyzer 5 or a suspension of the analysis process due to maintenance or the like. Since the sample buffer line can hold a large number of sample holders in a space-saving manner, it is preferable that the sample holder can be transferred between transport lines having different transport directions.
  • the sample transfer device 2 will be further described with reference to FIG. First, a process until a sample container mounted on a sample holder is transported to the analyzer 5 will be described.
  • the sample holder transferred from the holder transfer system 4 is transferred to the sample transfer line 10 of the sample transfer device 2 and stopped at the holder-side transfer position 25 by the holder stopping mechanism 14.
  • the sample carrying line 10 is, for example, a belt conveyor and keeps moving in the direction of the arrow in FIG. 2 except when the sample test automation system 1 and the analyzer 5 are stopped. Other lines described later are the same as the sample loading line 10.
  • the holder stopping mechanism 14 includes, for example, a bar that protrudes onto the sample carrying line 10 when the sample holder is stopped, and the bar blocks the sample holder and slides on the sample carrying line 10. Other stop mechanisms described later are the same as the holder stop mechanism 14.
  • the sample container mounted on the sample holder stopped at the holder-side transfer position 25 is gripped by the transfer arm 22 and transferred from the holder-side transfer position 25 to the sample rack 27 arranged at the rack-side transfer position 26. Is done.
  • the sample rack 27 is supplied in advance from the rack supply lane 21 that holds the plurality of sample racks 27 to the rack-side transfer position 26.
  • the sample rack 27 on which the sample containers are mounted at the rack-side transfer position 26 is unloaded from the sample transfer device 2 by the rack transport line 20 and is loaded into the analyzer 5 through the analyzer transfer line 28.
  • the sample holder that has been emptied by removing the sample container at the holder-side transfer position 25 is restarted to be transported on the sample loading line 10 and is unloaded to the holder transport system 4 via the holder unloading lines 13a and 13b. Is done.
  • the sample buffer line has a buffer carry-in line 11, a buffer carry-out line 12, a holder branching mechanism 15, a holder stop mechanism 16, a turn mechanism 17, and a holder stop mechanism 29.
  • the buffer carry-in line 11 and the buffer carry-out line 12 are transfer lines capable of holding a plurality of sample holders, and have different transfer directions as indicated by arrows in FIG.
  • the holder branching mechanism 15 controls whether the sample holder conveyed from the holder conveyance system 4 is carried into the buffer carry-in line 11 or goes straight on the sample carry-in line 10 by opening and closing a guide.
  • the sample holder carried into the buffer carrying line 11 is blocked by the holder stopping mechanism 16 and held in the buffer carrying line 11 until it is released from the holder stopping mechanism 16.
  • the sample holder released from the holder stopping mechanism 16 is transferred to the buffer unloading line 12 by a turn mechanism 17 described later with reference to FIG. 3, is blocked by the holder stopping mechanism 29, and is held in the buffer unloading line 12.
  • the sample holder released from the holder stop mechanism 29 or the sample holder that has moved straight on the sample carrying line 10 stops at the holder-side transfer position 25 as described above, and the sample container is transferred to the sample rack 27.
  • the turn mechanism 17 which is a main part of the present embodiment will be described with reference to FIG. FIG. 3 shows a state in which the holder stopping mechanism 16 blocks a plurality of sample holders 100 and releases one sample holder 101. Further, between the buffer carry-in line 11 and the buffer carry-out line 12, a passage port 45 having a size that allows the sample holder 100 to pass through, that is, a size larger than the diameter of the sample holder 100 is provided. The upstream end of the buffer inlet line 11 of the passage 45 is preferably rounded so that the sample holder 100 can pass through the passage 45 smoothly.
  • the turn mechanism 17 has a rotating shaft 40, an inclined guide 41, and a torsion spring 42.
  • One end of an inclined guide 41 is rotatably supported on the rotating shaft 40, and one end of a torsion spring 42 is fixed.
  • the rotating shaft 40 is provided on the buffer carry-out line 12 and on the downstream side of the buffer carry-in line 11 with respect to the passage opening 45.
  • the inclined guide 41 is disposed so as to be inclined with respect to the buffer carry-in line 11 so as to close the passage opening 45, and has a length enough to block the sample holder 100, for example, a length exceeding twice the diameter of the sample holder 100. Having.
  • the torsion spring 42 is connected to the rotation shaft 40 and the inclined guide 41.
  • the sample holder 101 transported by the buffer carry-in line 11 comes into contact with the inclined guide 41.
  • the inclined guide 41 is pushed out by the transport force of the buffer carry-in line 11, and the passage opening 45 is opened like the inclined guide (open) 41b in FIG.
  • the sample holder 101 moves so as to be guided to the passage 45 along the inclined guide 41.
  • the contact position between the sample holder 101 and the inclined guide 41 changes while the sample holder 101 moves to the passage port 45, and the moment force applied to the inclined guide 41 decreases as the contact position approaches the passage port 45.
  • the force of the specimen holder 101 pushing out the inclined guide 41 becomes weaker. Therefore, the elastic force of the torsion spring 42 causes the inclined guide 41 to return to the inclined guide (closed) 41a state.
  • the sample holder 101 guided to the passage port 45 is pushed out to the buffer carry-out line 12, and the transfer of the sample holder 101 from the buffer carry-in line 11 to the buffer carry-out line 12 is completed. I do.
  • the transferred sample holder 101 is transported by the buffer unloading line 12.
  • the inclined guide 41 pushed out by the transfer force of the buffer carry-in line 11 guides the sample holder 101 to the passage port 45, and returns to the original state by the elastic force of the torsion spring 42. It is pushed out to the buffer unloading line 12. That is, the sample holder 101 can be transferred between the buffer carry-in line 11 and the buffer carry-out line 12 having different transport directions without using a new driving mechanism.
  • the spring coefficient of the torsion spring 42 is such that the sample holder 101 guided to the passage port 45 can be pushed out to the buffer carry-out line 12 and the inclined guide 41 is pushed out by the contact of the sample holder 101 on the buffer carry-in line 11. It is desirable to be within the range.
  • the buffer carry-in line 11 and the buffer carry-out line 12 are not limited to the parallel arrangement. For example, as shown in FIG. 4, even when the buffer carry-in line 11 and the buffer carry-out line 12 intersect at an acute angle, the sample is transferred from the buffer carry-in line 11 to the buffer carry-out line 12 by the turn mechanism 17 of this embodiment.
  • the holder 101 can be delivered.
  • the turning mechanism 17 having the inclined guide 41 that returns to the position where the passage opening 45 is closed by the elastic force of the torsion spring 42 having one end fixed to the rotating shaft 40 has been described.
  • the turn mechanism is not limited to the configuration of the first embodiment.
  • a turn mechanism having a tension spring at the tip of the movable side of the inclined guide will be described. Note that the same components as those in the first embodiment are denoted by the same reference numerals, and description thereof is omitted.
  • the turn mechanism 60 of this embodiment will be described with reference to FIG.
  • the turn mechanism 60 has a rotating shaft 61, an inclined guide 62, and a pull spring 63.
  • One end of an inclined guide 62 is rotatably supported on the rotating shaft 61.
  • the rotation shaft 61 is provided on the buffer carry-in line 11 and downstream of the passage opening 45 with respect to the buffer carry-in line 11.
  • the inclined guide 62 is disposed so as to be inclined with respect to the buffer carry-in line 11 so as to close the passage opening 45, and has a length enough to block the sample holder 102, for example, a length exceeding twice the diameter of the sample holder 102. Having.
  • a tension spring 63 is attached between the other end of the inclined guide 62 and the side of the buffer carrying line 11.
  • the inclined guide 62 is stopped by the elastic force of the pull spring 63 so as to close the passage opening 45.
  • the sample holder 102 is transported by the buffer carry-in line 11, and when the sample holder 102 comes into contact with the inclined guide 62 as shown in FIG. 5B, the inclined guide 62 is pushed out by the transport force of the buffer carry-in line 11. Since the inclined guide 62 is still inclined with respect to the buffer carry-in line 11 after being pushed out, the sample holder 102 moves so as to be guided to the passage port 45 along the inclined guide 62.
  • the force by which the sample holder 102 pushes out the inclined guide 62 is weakened, and the elastic guide spring 63 attempts to return to a state where the inclined guide 62 closes the passage opening 45.
  • the inclined guide 62 returns to the original state, the sample holder 102 guided to the passage port 45 is pushed out to the buffer discharge line 12, and the transfer of the sample holder 102 from the buffer load line 11 to the buffer discharge line 12 is completed. I do.
  • the inclined guide 62 pushed out by the transport force of the buffer carry-in line 11 guides the sample holder 102 to the passage port 45, and returns to the original state by the elastic force of the pull spring 63, whereby the sample holder 102 It is pushed out to the buffer unloading line 12. That is, the sample holder 102 can be transferred between the buffer carry-in line 11 and the buffer carry-out line 12 having different transport directions without using a new driving mechanism.
  • the spring coefficient of the pull spring 63 can push out the sample holder 102 guided to the passage port 45 to the buffer carry-out line 12 and contact the sample guide 102 with the tilt guide 41. Is desirably within the range of being extruded.
  • the buffer carry-out line 12 looks like a sample holder 103. Can be transported.
  • the inclined guide 62 may be disposed so as to be inclined with respect to the buffer carry-in line 11 so as to cover the passage opening 45.
  • the rotating shaft 61 that rotatably supports one end of the inclined guide 62, The positions of the extension springs 63 attached to the ends may be exchanged. Further, the inclination guide 62 may be operated as described in the present embodiment by replacing the extension spring 63 with a compression spring.
  • the turning mechanism using the elastic force of the torsion spring 42 and the second embodiment has been described using the elastic force of the pulling spring 63.
  • the turn mechanism is not limited to the configuration using the elastic force of the spring.
  • a turn mechanism that utilizes an elastic force due to bending of an inclined guide will be described. Note that the same components as those in the first embodiment are denoted by the same reference numerals, and description thereof is omitted.
  • the turning mechanism 70 of the present embodiment will be described with reference to FIG.
  • the turn mechanism 70 has a support shaft 71 and an inclined guide 72.
  • the support shaft 71 supports the center of the inclined guide 72, and is provided at the center of the passage 75 between the buffer carry-in line 11 and the buffer carry-out line 12.
  • the passage port 75 has a size that is at least twice the diameter of the sample holder.
  • the inclined guide 72 has a length equivalent to the size of the passage 75 and has such a rigidity that the tip thereof is bent by the transfer force of the buffer carry-in line 11 and the buffer carry-out line 12.
  • the support shaft 71 does not rotate with the transport force of the buffer carry-in line 11 or the like, the inclination angle of the inclined guide 72 with respect to the buffer carry-in line 11 is adjusted according to the mode switching described later.
  • a stepping motor 73 or the like may be used for adjusting the inclination angle of the inclination guide 72.
  • the stepping motor 73 is disposed on the back side of the transport surface of the buffer carry-in line 11 and the buffer carry-out line 12.
  • the turning mechanism 70 of the present embodiment switches between a mode for transferring the sample holder between the buffer carry-in line 11 and the buffer carry-out line 12 and a mode for not transferring the sample holder by adjusting the tilt angle of the tilt guide 72.
  • FIG. 6A shows a transfer mode
  • FIG. 6B shows a non-transfer mode.
  • the inclination angle is set so that the distance between the inclined guide 72 and the end of the passage 75 is equal to or larger than the diameter of the sample holder 104.
  • the tilt guide 72 is bent by the transport force of the buffer carry-in line 11 or the like.
  • the sample holder 104 and the like move so as to be guided to the passage opening 75 along the bent tilt guide 72 because the tilt guide 72 is kept tilted with respect to the buffer carry-in line 11. Since the moment force applied to the tilt guide 72 decreases with the movement of the sample holder 104 and the like, the bent tilt guide 72 attempts to return to the original state.
  • the inclination angle is set such that the inclination guide 72 is parallel to the buffer carry-in line 11 or the buffer carry-out line 12. At such a tilt angle, the passage opening 75 is closed by the tilt guide 72, and the sample holder 106 and the sample holder 107 are not transferred, so that each sample holder can move straight.
  • the inclined guide 72 which is bent by the transport force of the buffer carry-in line 11 or the like guides the sample holder 104 or the sample holder 105 to the passage opening 75, and the inclined guide 72 returns to the original state by the elastic force due to the bending. As a result, the sample holder 104 and the like are pushed out to the adjacent transport line. That is, it is possible to transfer the sample holder 104 and the like between the buffer carry-in line 11 and the buffer carry-out line 12 having different transport directions without using a new driving mechanism.

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Control Of Conveyors (AREA)
  • Intermediate Stations On Conveyors (AREA)

Abstract

La présente invention permet le transfert d'un porte-échantillon entre des lignes de transport qui ont des directions de transport différentes, sans utiliser un nouveau mécanisme d'entraînement. Cette ligne de transport de porte-échantillon comprend : une première ligne de transport pour transporter un porte-échantillon dans une première direction ; une seconde ligne de transport pour transporter le porte-échantillon dans une seconde direction différente de la première direction ; et un orifice de passage qui est disposé entre la première ligne de transport et la seconde ligne de transport et à travers lequel passe le porte-échantillon. La ligne de transport de porte-échantillon est caractérisée en ce qu'elle comporte en outre un guide incliné qui est incliné par rapport à la première ligne de transport de façon à guider le porte-échantillon vers l'orifice de passage, le guide incliné étant poussé ou déformé par la force de transport de la première ligne de transport lorsque le porte-échantillon vient en contact avec le guide incliné ; et, conformément au mouvement du porte-échantillon le long du guide incliné, le guide incliné est renvoyé à l'état d'origine de telle sorte que le porte-échantillon passe à travers l'orifice de passage et est transféré à la seconde ligne de transport.
PCT/JP2019/032541 2018-08-23 2019-08-21 Ligne de transport de porte-échantillon et système d'automatisation d'inspection d'échantillons WO2020040165A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2020538417A JP7163394B2 (ja) 2018-08-23 2019-08-21 検体ホルダ搬送ライン及び検体検査自動化システム
CN201980052602.2A CN112534272A (zh) 2018-08-23 2019-08-21 检体托架传送线和检体检查自动化系统

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018156202 2018-08-23
JP2018-156202 2018-08-23

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WO2020040165A1 true WO2020040165A1 (fr) 2020-02-27

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JP (1) JP7163394B2 (fr)
CN (1) CN112534272A (fr)
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Citations (2)

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US5388682A (en) * 1994-02-23 1995-02-14 Peco Controls Corporation Diverter for diverting articles transported along a conveyor belt
US20130126302A1 (en) * 2011-11-07 2013-05-23 Beckman Coulter, Inc. Magnetic damping for specimen transport system

Family Cites Families (9)

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JP4936740B2 (ja) * 2006-02-09 2012-05-23 日本メクトロン株式会社 フレキシブルプリント基板の製造装置および製造方法
FR2911587B1 (fr) 2007-01-22 2009-04-17 Sidel Participations DISPOSITIF DE CONVOYAGE D'OBJETS, NOTAMMENT PREFORMES, BOUTEILLES OU ANALOGUES, PAR SOUFFLAGE D'air
CA2718881C (fr) * 2010-10-26 2015-12-29 Engineered Lifting Systems & Equipment Inc. Transporteur a courroie pour le dechargement des colis des conteneurs d'expedition
JP5699627B2 (ja) * 2011-01-21 2015-04-15 ブラザー工業株式会社 インクジェット記録装置
EP2902790A4 (fr) * 2012-09-26 2016-06-01 Hitachi High Tech Corp Dispositif de transport d'échantillons et système automatique pour inspection de spécimens
CN103482306B (zh) * 2013-09-22 2016-06-22 芜湖万向新元环保科技有限公司 可调式橡胶片输送机
JP6107707B2 (ja) * 2014-03-04 2017-04-05 株式会社村田製作所 搬送装置
CN107533075B (zh) * 2015-04-27 2020-10-16 株式会社日立高新技术 检体容器倾斜矫正机构及其控制方法
JP6668123B2 (ja) * 2016-03-17 2020-03-18 株式会社日立ハイテク 検体搬送システム

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5388682A (en) * 1994-02-23 1995-02-14 Peco Controls Corporation Diverter for diverting articles transported along a conveyor belt
US20130126302A1 (en) * 2011-11-07 2013-05-23 Beckman Coulter, Inc. Magnetic damping for specimen transport system

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JPWO2020040165A1 (ja) 2021-08-26
JP7163394B2 (ja) 2022-10-31
CN112534272A (zh) 2021-03-19

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