WO2020034202A1 - Composition de nettoyage - Google Patents

Composition de nettoyage Download PDF

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Publication number
WO2020034202A1
WO2020034202A1 PCT/CN2018/101105 CN2018101105W WO2020034202A1 WO 2020034202 A1 WO2020034202 A1 WO 2020034202A1 CN 2018101105 W CN2018101105 W CN 2018101105W WO 2020034202 A1 WO2020034202 A1 WO 2020034202A1
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Prior art keywords
weight
composition according
cleansing composition
relation
contained
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PCT/CN2018/101105
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English (en)
Inventor
Dan KE
Ziyin WANG
Original Assignee
Beiersdorf Daily Chemical (Wuhan) Co. Ltd.
Beiersdorf Ag
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Application filed by Beiersdorf Daily Chemical (Wuhan) Co. Ltd., Beiersdorf Ag filed Critical Beiersdorf Daily Chemical (Wuhan) Co. Ltd.
Priority to PCT/CN2018/101105 priority Critical patent/WO2020034202A1/fr
Priority to PCT/EP2019/069019 priority patent/WO2020035245A1/fr
Publication of WO2020034202A1 publication Critical patent/WO2020034202A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0291—Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters

Definitions

  • the present invention relates to a cosmetic cleansing composition, especially a face cleansing composition, in particular suitable as a make-up remover.
  • the composition has effective cleansing properties and at the same is a mild, non-irritating composition.
  • the composition is made available in form of a cleansing water, based on a micelle in water system.
  • make-up is used to improve the outward appearance, in particular the appearance of the face.
  • make-up was used in ancient times. In Egypt, at the times when the pharaohs were governing the country, the use of make-up for the eyes, lips and cheeks was common. Women and men used it to protect the skin against the sun, but also for beautification.
  • make-up is merely used to improve in particular the outward appearance of the face.
  • make-up removers The applied make-up has to be removed. This may be achieved by face cleansers or products solely developed to remove make-up, so called make-up removers.
  • the skin of the face is a relatively sensitive skin, therefore it is recommended to use mild cleansing compositions.
  • Make-up compositions contain a great number of raw materials, which are of very different chemical nature.
  • the dyes, contained in make-up compositions are selected from inorganic pigments such as silicates (magnesium silicate (talc) , aluminum silicate (kaolin) ) , and metal oxides (chrome, iron, manganese, titanium, and zinc oxides) , and/or organic pigments.
  • Binding means may be esters of stearic acid, lanolin alcohol and lanolin acetate.
  • waxes such as for instance, beeswax or carnauba wax
  • oils such as for instance, paraffin oil, silicone oil or castor oil
  • preservatives, antioxidants, thickeners and other additives may be comprised.
  • nonpolar substances such as waxes, oils and silicone oils and pigments of low solubility, such as talc or titanium oxide, must be solubilized. This holds true for foundations, lipsticks, eye shadows, eye pencils, and alsofor long-lasting and waterproof products.
  • compositions suitable to remove make-up as well.
  • Different types of compositions are described and respective products are in the market.
  • the compositions may be in form of emulsions, creamy, milky or liquid ones, gels and oily compositions, sometimes with two distinct phases, which are mixed upon shaking.
  • Products, which are mainly water-based, have also been described.
  • WO 2016/146360 A1 discloses a facial cleansing preparation, especially for removing make-up and toning the skin, in the form of a 3-in-1 product.
  • the product comprises an oily phase, an aqueous phase and benzethonium chloride and is free of silicone based compounds.
  • the oily phase contains isohexadecane and/or C15-19-alkanes.
  • WO 2017/005485 A1 describes an impregnation means, namely a composition for impregnating clothes which are intended for face cleansing.
  • Said composition is based on micellar technology and contains at least one acyl glutamate and at least one alkyl glycoside.
  • compositions of the invention are not composed of two phases and/or are not intended to be used as an impregnation means.
  • the purpose of the compositions of the invention is the removal of make-up, also and especially the removal of eye make-up, it is important, that the compositions are mild and cause no irritations, especially in the eye area.
  • emulsifiers which are polyglycerol based, contributes to an improvement of compositions intended for face cleansing, especially make-up removing.
  • WO 2012/168126 A2 discloses cleansing compositions, which are transparent and contain nature based raw materials.
  • polyglycerol emulsifiers are contained. But no working example discloses the use of said emulsifiers.
  • EP 3078365 A1 The aim of EP 3078365 A1 is to solubilize fatty agents in aqueous phases.
  • Compositions containing a gemini surfactant, an alkylpolyglucoside and a polyglycerol fatty acid ester are described. Said compositions may also be used as cleansing compositions.
  • US 2012/0157365 A1 describes mild cleansing compositions containing polyglyceryl nonionic surfactants. There is no disclosure that the compositions according to US 2012/0157365 are suitable for removing make-up.
  • CN 106726770 A describes a cleansing water based on micellar technology.
  • Said cleansing water containsdecylglucoside and/or polyglyceryl-6caprylate and/or polyglyceryl-10 oleate and may be used for removing make-up.
  • compositions being clearly directed to face cleansing and make-up removal.
  • Another aim is to achieve a further improvement in mildness, so that there is scarcely any, at best no, irritation observed of the face skin and eye area.
  • a cleansing composition containing nonionic surfactants chosen from alkyl poly glucosides, anionic surfactants based on amino acids and a mixture of polyglycerol based emulsifiers.
  • the invention is directed to a cleansingcomposition, especially a face cleansing composition containing
  • the composition contains water, hence it is an aqueous composition.
  • the water content ranges from 80 to 99 %by weight, preferably 90 to 98 %by weight, in relation to the total weight of the composition.
  • the cleansing composition is a cleansing water.
  • skin encompasses the skin, but also the hair emerging from the skin at nearly all parts of the body.
  • the present invention is especially directed to human skin.
  • composition according to the invention contains surfactants, namely at least one alkyl poly glycoside and at least one anionic surfactant based on an amino acid.
  • the nonionic surfactant (s) is/are chosen from alkyl poly glycosides, represented by the formula RO- (Z) x, wherein R is the alkyl group having 6 to 30 carbon atoms, Z is a sugar moiety and x is the number of sugar moieties (1.1-5 on average) .
  • the alkyl poly glycosides according to the invention may have a specific alkyl group, havinga distinct number of carbon atoms.
  • alkyl poly glycosides are produced starting from natural oils, preferably plant oils, more preferably coconut oil.
  • the alkyl group R is a mixture of the alkyl groups of the respective fatty acids of natural oil used as a starting material.
  • alkyl poly glycosides have alkyl groups, whereR essentially consists of C8 to C18 alkyl groups, preferably C8 to C12.
  • the sugar moiety may be a monosaccharide or an oligosaccharide.
  • the sugar moieties have 5 or 6 carbon atoms, which are contained as monosaccharides or oligosaccharides.
  • suitable sugar moieties are glucose, fructose, galactose, arabinose, ribose, xylose, lyxose, allose, altrose, mannose, gulose, idose, talose and sucrose. It is preferred, if the sugar moieties are glucose orsucrose. It is more preferred, if the sugar moiety is glucose.
  • the alkyl poly glycosides contain 1.1 to 5 sugar moieties on average, preferably 1.1 to 2.0, more preferably 1.1 to 1.8. It is most preferred, if the alkyl poly glycoside is decylglucoside. Decylglucoside may be purchasedas a composition of 53%Decylglucoside and 47%water, under the trade name Plantacare 2000 UP from BASF Personal Care and Nutrition.
  • Alkyl poly glycoside are known to be mild surfactants, however to further improve the mildness of the compositions according to the invention, it is advantageous to reduce the amount of the alkyl poly glycosides as much as possible. Hence, it is preferred, if the at least one alkyl poly glycoside is contained in a total amount of 0.01 to 2.0 %by weight, preferably 0.02to 1.0 %by weight, more preferably 0.05 to0.5 %by weight in the composition according to the invention, in relation to the active content and in relation to the total weight of the composition.
  • the anionic surfactants based on amino acids consist of an amino acid and an acyl group; the acyl group being mostly attached to the functional groups of the amino acid.
  • the at least one amino acid surfactant is preferably chosen from N-acyl amino acids, more preferably N-acyl glutamate, most preferably disodium/sodium cocoylgluatamate, contained in the composition according to the invention.
  • the amount of the monosodium salt (mono sodium cocoyl glutamate) is dependent on the pH value. The lower the pH value, the higher the relative amount of mono sodium cocoylgluatamate.
  • Disodium cocoyl glutamate is available as a composition of 25%Disodium Cocoyl Glutamate, 63%water, 5%Propylene Glycol, 4.5%Sodium Chloride and 2.5%Sodium Sulfate under the trade name Hostapon -CCG from Clariant.
  • anionic surfactants based on amino acids are known to be mild surfactants.
  • the amount of the at least one anionic surfactant based on an amino acid is as low as possible.
  • the at least one anionic surfactant based on an amino acid is contained in a total amount of 0.001 to 0.05 %by weight, preferably 0.002 to 0.01%by weight in the composition according to the invention, in relation to the active content and in relation to the total weight of the composition.
  • Polyglycerol based emulsifiers are emulsifier having a polyglycerol chain, wherein the number behind the term polyglycerol denotes the number of glycerol molecules.
  • a fatty acid, saturated or unsaturated, having 4 to 30 carbon atoms, preferably 6 to 20 carbon atoms is esterified with the polyglycerol chain.
  • the fatty acid may be a single fatty acid with a distinct number of carbon atoms or a mixture of fatty acids. These mixtures may be derived from vegetable oils, such as for instance palm oil, coco nut oil or soy oil.
  • caprylic acid is esterified to polyglycerol chain having mostly 6 glycerol units, resulting in Polyglyceryl-6 caprylate.
  • caproic acid is esterified to polyglycerol chain having mostly 4 glycerol units, resulting in Polyglyceryl-4 caprate.
  • ricinoleic acid is esterified to polyglycerol chain having mostly 6 glycerol units, resulting in Polyglyceryl-6 Ricinoleate.
  • the mixture of polyglycerol based emulsifiers contains at least two polyglycerol based emulsifiers, preferably chosen from the preferred emulsifier, namely from Polyglyceryl 3 cocoate, Polyglyceryl-6 caprylate, Polyglyceryl-4 caprate, and Polyglyceryl-6 Ricinoleate.
  • the mixture contains all four preferred emulsifiers, namely Polyglyceryl 3 cocoate, Polyglyceryl-6 caprylate, Polyglyceryl-4 caprate, and Polyglyceryl-6 Ricinoleate. It is even more preferred, if the mixture contains only the four preferred emulsifiers, namely Polyglyceryl 3 cocoate, Polyglyceryl-6 caprylate, Polyglyceryl-4 caprate, and Polyglyceryl-6 Ricinoleate.
  • each of the four preferred emulsifiers namely Polyglyceryl 3 cocoate, Polyglyceryl-6 caprylate, Polyglyceryl-4 caprate, and Polyglyceryl-6 Ricinoleate, is contained in the mixture in an amount of 17 to 27 %by weight of the mixture.
  • a mixture suitable according to the present invention may be purchased under the trade name Tego Solve 61 from Evonik Nutrition and Care GmbH.
  • the mixture of polyglycerol based emulsifiers is contained in the composition of the invention in an amount of 0.1 to 4.0 %by weight, preferably 0.5 to 3.0 %by weight in relation to the total weight of the composition.
  • Ethoxylated alkyl glycerides emulsifier (s) is/are contained.
  • Ethoxylated alkyl glycerides are mono-, di, and/or tri-glycerides having ethylene glycol units, which is indicated with the abbreviation PEG.
  • the alkyl group may be derived from a single fatty acid having a distinct number of carbon atoms or a mixture of fatty acids. These mixtures may be derived from vegetable oils, such as for instance palm oil, coco nut oil or soy oil. It is preferred, if the mixture of fatty acids is derived from coco nut oil.
  • the average number of ethylene glycol units per molecule is indicated by the number behind “PEG” . For instance PEG-7 means that on average 7 ethylene glycol units are present per molecule.
  • PEG-7 Glyceryl Cocoate is present in the composition according to the invention.
  • the at least one ethoxylated alkyl glyceride emulsifier is contained in the composition of the present invention in a total amount of 0.1 to 7.5 %by weight, preferably 0.2 to 2.0 %by weight, in relation to the total weight of the composition.
  • the interaction of the at least one alkyl poly glycoside, the at least one anionic surfactant based on an amino acid, the mixture of polyglycerol based emulsifiers, and the at least one ethoxylated alkyl glyceride emulsifier leads to a micellar in water system. It is believed that the micelles are generated by the anionic surfactant based on an amino acid and the alkyl glycosides, the polyglycerol based emulsifiers, and the ethoxylated alkyl glyceride emulsifiersare inserted in the micellar structure.
  • the micelles are built by aggregation of amphiphilic molecules, the hydrophilic part of which is orientated outwards in the aqueous phase, whereas the lipophilic part is directed to the inside of the micelle.
  • Compositions containing micellar structures are very effectively removing make-up.
  • a further object of the present invention is a cleansing composition, especially face cleansing composition containing
  • the composition according to the invention is an aqueous composition. Nevertheless it is advantageous, if hydrophobic components are contained. For instance, these hydrophobic components may be perfumes and/or certain preservatives.
  • these hydrophobic components may be perfumes and/or certain preservatives.
  • at least one additional emulsifier or substance having emulsifying properties may befurther contained, being different from the emulsifiers contained in the mixture of polyglycerol based emulsifiers and the ethoxylated alkyl glyceride emulsifiers. It is preferred, if said emulsifier (s) has/have ethylene glycol units.
  • one or more emulsifiers selected from ethoxylated Hydrogenated Castor Oil, is/are contained. It is even more preferred, if PEG-40 Hydrogenated Castor oil and/or PEG-60 Hydrogenated Castor Oil is/are contained. It is even further preferred, if PEG-40 Hydrogenated Castor oil is contained.
  • the at least one additional emulsifier is contained in the composition of the present invention in a total amount of 0.1 to 7.5 %by weight, preferably 0.5 to 5.0 %by weight, in relation to the total weight of the composition.
  • composition of the present invention may further contain at least one humectant.
  • Humectants are hygroscopic substances which bind water and therefore provide moisture.
  • the hygroscopic quality is due to hydrophilic substituents of the molecule, in many cases hydroxyl groups, but other functional groups as amine or carboxyl groups may fulfill the same function.
  • humectantsare diols such as 1, 2-pentandiol, 1, 2-hexandiol, and 1, 2-octandiol, propylene glycol, hexylene glycol, and butylene glycol, glyceryl triacetate, glycerol, sorbitol, xylitol, maltitol, polydextrose, urea, Aloe vera gel, alpha hydroxy acids such as lactic acid, honey. It is preferred, if the composition according to the invention contains glycerol, sorbitol, and/or 1, 2-hexandiol.
  • the one or more humectant (s) is/are contained in the composition according to the invention in a total amount of 0.1 to 7.5 %by weight, preferably 1.0 to 5.0 %by weight, relative to the total weight of the composition.
  • the values are referring to the active content of the humectant.
  • the composition of the present invention may further contain at least one compound for having a caring and/or conditioning function for the skin. Therefore said compound has to be able to get into contact with the skin in order to contribute to a caring and conditioning effect.
  • compounds are chosen, which have a naturally derived backbone. Examples are polymers, which are originated from plants, especially celluloses. In general, the cellulose molecules are modified resulting in an easier usage in cosmetic formulations. There are many kinds of modifications possible and hence many kinds of different cellulose molecules available as cosmetic ingredient.
  • the Polyquaternium-10 iscontained in the composition according to the invention in an amount of 0.01 to 1.0 %by weight, more preferably 0.03 to 0.5 %by weight, relative to the total weight of the composition.
  • the values are referring to the active content of Polyquaternium-10.
  • composition of the present invention may further contain one or more complexing agents.
  • Complexing agents may contribute to clarity or transparency of a composition.
  • the complexing agents may be chosen from aminopolycarboxylic acids and anions thereof, such as, for example, ethylenediaminetetraacetic acid (EDTA) and anions thereof, nitrilotriacetic acid (NTA) and anions thereof, hydroxyethylenediaminotriacetic acid (HOEDTA) and anions thereof, diethyleneaminopentaacetic acid (DPTA) and anions thereof, trans-1, 2-diaminocyclohexanetetraacetic acid (CDTA) and anions thereof.
  • EDTA ethylenediaminetetraacetic acid
  • NTA nitrilotriacetic acid
  • HOEDTA hydroxyethylenediaminotriacetic acid
  • DPTA diethyleneaminopentaacetic acid
  • CDTA 2-diaminocyclohexanetetraacetic acid
  • the at least one complexing agent is contained in the composition of the invention in an amount of 0.1 to 1.0 %by weight, relative to the total weight of the composition.
  • composition according to the present invention may further contain preservatives. All preservatives, which are allowed and suitable for cosmetic compositions, may be contained in the composition according to the invention.
  • parabens are characterized by the following formula
  • R is a linear or branched alkyl residue of 1 to 5 carbon atoms.
  • Common parabens are methyl-, ethyl-, propyl-, butylparaben, as well as isopropyl-, isobutyl-, pentyl-, and phenylparaben. It is more preferred, if methyl-and/or ethylparabenare contained.
  • the one or more paraben (s) is/are contained in a total amount of 0.01 to 2.0 %by weight, preferably 0.05 to 1.0 %by weight, more preferably 0.1 to 0.8 %by weight in the composition according to the invention, in relation to the total weight of the composition.
  • Phenoxyethanol is contained in the composition according to the invention.
  • Phenoxyethanol is contained in an amount of 0.01 to 5.0 %by weight, preferably 0.05 to 3.0 %by weight, more preferably 0.1 to0.9 %by weight in the composition according to the invention, in relation to the total weight of the composition.
  • the pH value of the composition according to the invention ranges from 4.5 to 7.5, preferably 4.5 to 5.0.
  • the pH value may be adjusted by any physiologically acceptable means. However, it is preferred to use organic acids, selected from citric acid and/or lactic acid, more preferred citric acid to adjust the pH value.
  • composition according to the invention is clear and transparent.
  • the compositions may be colored by containing colorants.
  • it is a pink or a black composition according to the invention. If a pink composition is produced, a pink colorant is further contained in the composition.
  • the pink colorant may be purchased from Goldmann (Sensient) under the trade name FD&C Red No 40 07700-C.
  • the pink colorant is contained in an amount of 0.00001 to 0.001%by weight, in relation to the total weight of the composition.
  • a black composition is produced, more preferably a mixture of colorants is further contained in the composition.
  • the mixture even more preferably contains a red colorant, available as FD&C Red No 40 07700-C from Goldmann (Sensient) , a green colorant, available D&C Green No. 5 (5/002155) 656848 from Symrise, and a yellow colorant, available as Unicert Yellow K7164-J from Sensient.
  • the mixture is contained in an amount of 0.00015 to 0.005 %by weight, in relation to the total weight of the composition.
  • Fig. 1 shows the testing procedure of make-up removing (MUR) efficacy using a Chromometer.
  • Fig. 2 shows comparative results of MUR for two compositions BLWater 35 and EM-Water 41.
  • composition according to the present invention may be prepared by any technique known or effective to prepare a cleansing composition of the kind of the present invention.
  • the process to prepare the composition of the present invention comprises conventional formulating and mixing techniques.
  • composition of the present invention is preferably produced with the following procedure:
  • EM-water 41 EM-water 41
  • BLWater 35 comparative composition
  • the composition of EM-water 41 and BLWater 35 is the same as described below for the epicutaneous patch test.
  • the test procedure is illustrated in Fig. 1, wherein
  • T0 Chromometer value before application of make-up
  • T1 Chromometer value after application of make-up
  • T2 Chromometer value after using the productsBLWater 35 or EM-Water 41.
  • composition according to the invention is mild and non-irritative a RBC assay (1 hour protocol) was performed.
  • test samples The cell membrane destroying and protein denaturating properties of test samples are examined by measuring the release of haemoglobin (haemolysis) and the spectral changes of haemoglobin (protein denaturation) from bovine erythrocytes.
  • the RBC test (1 hour) has been used within the EC/HO International Validation Study (Balls et al., 1995) and the COLIPA Validation Project on alternatives to the Draize eye irritation test (Brantom et al., 1997) . The test demonstrated its validity for the assessment of the in vivo eye irritation potential.
  • bovine erythrocytes are incubated by shaking for one hour at room temperature with increasing concentrations of test sample (1, 10, 100, 1000, 10000, 100000 mg/l in PBS at pH 7.4) . After centrifugation the spectral absorption of released hemoglobin is determined photometrically at 541 nm in the resulting supernatants (extracellular hemoglobin) . The cells of the pellet are lysed with water and the spectral absorption of this solution (intracellular hemoglobin) is also determined at 541 nm.
  • the D low (threshold concentration [mg/l] > 10%denaturation) and the D max (maximum denaturation [%] ) are calculated from the change of total hemoglobin absorption (intra-and extracellular) in comparison to the total native hemoglobin (HbO 2 ) of the 100%control.
  • composition according to the invention (EM-Water#41) was analyzed by the RBC assay (1 hour protocol) together with compositions EM-Water#30, EM-Water#42, EM-Water#43, and EM-Water #44.
  • composition according to the invention does not cause any irritations aHen’s Egg Test was conducted.
  • the HET-CAM is used to assess the acute eye irritation potential of test compounds (chemicals, cosmetic formulations etc. ) .
  • Test compounds are applied for five minutes directly onto the chorioallantoic membrane of the hen’s egg.
  • the time of occurrence and/or severity of vascular injuries (hemorrhage) , coagulations (intra-and extravascular) and other effects are assessed visually and recorded. The earlier a reaction occurs and the stronger the reaction is, the higher is the eye irritation potential.
  • test method is based on a protocol used in a large German validation study and available as DB-ALM protocol no. 47 (https: //ecvam-dbalm. jrc. ec. europa. eu/) .
  • Fertile White Leghorn chicken eggs are incubated at 37.5°C ( ⁇ 0.5°C) and relative humidity of 62.5 % ( ⁇ 7.5 %) for nine to ten days.
  • the egg shell is opened at the air cell pole and the inner membrane is removed carefully to free the chorioallantoic membrane (CAM) .
  • 300 ⁇ l of liquid or 100 mg of solid test compounds are applied to the surface of the CAM and incubated for five minutes.
  • the membrane is examined visually by naked eye (and checked with a stereo microscope at 30x magnification) for any damage and the time is recorded at which reactions appear. Furthermore, the degree of severity for each reaction is assessed (no, slight, moderate or severe reaction) .
  • I irritation threshold
  • reaction time protocol For transparent test compounds start of reactions and severity is recorded (reaction time protocol) .
  • severity of the reactions after five minutes is recorded (solids protocol) .
  • Example 5 In vivo testing
  • an epicutaneous patch test was conducted to evaluate the skin tolerance. 31 subjects ranging from 21 to 64 years of age, of those 11 subjects with highly SDS sensitive skin (35%) , 13 subjects with SDS sensitive skin (42%) and 7 subjects with less /not SDS sensitive skin (23%) took part in the study. 4 products were tested using the following procedures to assess skin reactions. Test products and internal standard were applied to the subject’s back, where they remained for 24 hours. The application sites were visually assessed approximately 3 hours (day 2 scores) after removal of the patches in accordance with the Irritation Grading Scale. The application was repeated up to 4 times for 21 hours each, or up to the first sign of skin irritation (score ⁇ 1) . Visual scoring was performed 3 hours after patch removal on days 3, 4 and 5.
  • Glyceryl Stearate 1.20 Palmitic Acid 1.21 Stearic Acid 1.18 Aqua Ad 100 Ad 100 Ad 100 CeraMicrocristallina 1.32 ParaffinumLiquidum 0.68 CitricAcid 0.01-0.1 0.01-0.1 PEG-7 Glyceryl Cocoate 0.50 1.00 Cetyl Alcohol 1.00 Trisodium EDTA 0.20 0.20 EthylhexylMethoxycinnamate 2.00 Phenoxyethanol 0.60 0.60 0.40 Dimethicone 0.75 Hydrogenated Coco-Glycerides 1.00 SimmondsiaChinensis Seed Oil 1.00 Panthenol 0.53 Glycerin 0.50 0.50 3.04 Sodium Hyd roxide 0.18 PEG-40 Hydrogenated Castor Oil 0.90 0.90 Butylene Glycol 3.00 Sodium PCA 0.25 Sodium Lactate 0.25 Polyquaternium-10 0.10 0.10 Carbomer 0.15 Stearyl Alcohol 1.00 Titanium Dioxide (nano) 0.37 DecylGlucoside 0.1 1 0.11
  • composition according to the invention (62765-30; em-water 41) was evaluated as very good, indicating a very good skin tolerance.

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Abstract

La présente invention concerne une composition de nettoyage, en particulier une composition de nettoyage du visage, appropriée en tant que démaquillant, comprenant au moins un alkylpolyglycoside, au moins un tensioactif anionique à base d'acide aminé, un mélange d'émulsifiants à base de polyglycérol, et au moins un émulsifiant glycéride d'alkyle éthoxylé. La composition présente des propriétés de nettoyage efficace et est, en même temps, une composition douce et non irritante. La composition est mise à disposition sous forme d'eau nettoyante, sur la base de micelles dans un système aqueux.
PCT/CN2018/101105 2018-08-17 2018-08-17 Composition de nettoyage WO2020034202A1 (fr)

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Application Number Priority Date Filing Date Title
PCT/CN2018/101105 WO2020034202A1 (fr) 2018-08-17 2018-08-17 Composition de nettoyage
PCT/EP2019/069019 WO2020035245A1 (fr) 2018-08-17 2019-07-15 Composition nettoyante

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PCT/CN2018/101105 WO2020034202A1 (fr) 2018-08-17 2018-08-17 Composition de nettoyage

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WO2020034202A1 true WO2020034202A1 (fr) 2020-02-20

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