WO2019230579A1 - Préparation cosmétique à sensation de chaleur - Google Patents

Préparation cosmétique à sensation de chaleur Download PDF

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Publication number
WO2019230579A1
WO2019230579A1 PCT/JP2019/020585 JP2019020585W WO2019230579A1 WO 2019230579 A1 WO2019230579 A1 WO 2019230579A1 JP 2019020585 W JP2019020585 W JP 2019020585W WO 2019230579 A1 WO2019230579 A1 WO 2019230579A1
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WO
WIPO (PCT)
Prior art keywords
acid
warm
oil
tranexamic acid
dimethicone
Prior art date
Application number
PCT/JP2019/020585
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English (en)
Japanese (ja)
Inventor
裕人 白神
則子 大道口
Original Assignee
株式会社 資生堂
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by 株式会社 資生堂 filed Critical 株式会社 資生堂
Priority to JP2020522151A priority Critical patent/JP7299886B2/ja
Priority to CN201980035396.4A priority patent/CN112165932A/zh
Priority to TW108118525A priority patent/TW202002943A/zh
Publication of WO2019230579A1 publication Critical patent/WO2019230579A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/45—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to a warm cosmetic that gives a warm feeling when applied to the skin. More specifically, the present invention relates to a warm sensation cosmetic that can stably contain tranexamic acid and has a good feeling of use.
  • exothermic substances are blended in cosmetics.
  • humectants such as polyhydric alcohols, zeolites, metal salts or metal oxides are widely used. All of these are hygroscopic and generate heat when in contact with moisture on the skin, thereby bringing warmth to the skin.
  • Patent Document 1 since a moderate viscosity and an excellent warmth imparting effect can be obtained, a polyhydric alcohol is emulsified with a specific nonionic surfactant to obtain an oil type in a polyhydric alcohol. Has been proposed.
  • Patent Document 2 a leave-on-type warming cosmetic that does not need to be washed off after application has been developed in anticipation of various effects of imparting warmth to the skin.
  • tranexamic acid blended in a skin external preparation as a whitening agent requires a large amount of water to be dissolved. Therefore, it was difficult to mix tranexamic acid with warm cosmetics. Moreover, since tranexamic acid has strong crystallinity and has a problem of precipitation and solidification over time, it is necessary to sufficiently suppress precipitation over time in cosmetics containing tranexamic acid.
  • JP 2014-37404 A Japanese Unexamined Patent Publication No. 2016-193841
  • An object of the present invention is to provide a warming cosmetic composition that exhibits an excellent warmth-sensing effect and is stably formulated with tranexamic acid.
  • the above object was achieved by blending tranexamic acid, water that is 5 times the amount of tranexamic acid, polyhydric alcohol, and organic acid and / or inorganic acid.
  • the present inventors have found that this can be done and have completed the present invention. That is, the present invention Tranexamic acid, 5% by weight or less water of tranexamic acid, Provided is a warm cosmetic composition containing a polyhydric alcohol and an organic acid and / or an inorganic acid.
  • the present invention can provide a warm cosmetic that exhibits an excellent warm feeling imparting effect, is sufficiently dissolved in tranexamic acid, and sufficiently suppresses precipitation over time.
  • the warm sensation cosmetic of the present invention is characterized by containing tranexamic acid, water having an amount of 5% by mass or less of tranexamic acid, a polyhydric alcohol, and an organic acid and / or an inorganic acid as essential components.
  • Tranexamic acid used in the warm cosmetic composition of the present invention is trans-4-aminomethylcyclohexanecarboxylic acid and is a drug known as a cosmetic ingredient. It is often formulated as a rough skin improvement or whitening agent.
  • the amount of tranexamic acid in the cosmetic of the present invention is 0.1 to 5% by mass, preferably 1.0 to 3.0% by mass, based on the total amount of the cosmetic. If the blending amount of tranexamic acid is less than 0.1% by mass, a sufficient drug effect cannot be obtained. If the blending amount exceeds 5% by mass, precipitation tends to occur, and the amount of water required for dissolution increases. It is not preferable in that the feeling of feeling decreases.
  • water in the warm cosmetic composition of the present invention, water (ion exchange water, purified water, natural water, etc.) can be blended as an aqueous solvent for tranexamic acid as long as the usability and stability of the cosmetic composition are not impaired.
  • the blending amount of the aqueous solvent is 10% by mass or less, preferably 8% by mass or less, more preferably 5%, based on the total amount of the warming cosmetic. It should be kept below mass%.
  • the blending amount of water is 5% by mass or less of the blending amount of tranexamic acid, Furthermore, it is preferable to set it to 2 times mass% or more and 5 times mass% or less.
  • the polyhydric alcohol used in the warming cosmetic composition of the present invention is a component that imparts warmth when applied to the skin and is not limited, but examples include glycerin, diglycerin, polyglycerin, 1 , 3-butylene glycol, ethylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol (PEG-8, etc.), polypropylene glycol, polyethylene glycol / polypropylene glycol, methylglutes-10 (polyoxyethylene methylglucoside), trimethylolethane, tri Examples include methylolpropane, erythritol, pentaerythritol, sorbitan, glucose, sorbitol, maltitol, sucrose, raffinose, hexylene glycol, 1,2-pentanediol, and trehalose. Rukoto can.
  • glycerin is preferably used, and other dipropylene glycol, diglycerin, sorbitol, and the like are preferably blended and used as appropriate.
  • the blending of the polyhydric alcohol leads to a warm sensation effect and leads to a bright and bloody skin, and at the same time prevents moisture evaporation on the skin surface due to a high moisturizing effect, and can prevent makeup collapse due to drying.
  • the blending amount of the polyhydric alcohol in the cosmetic of the present invention is 20% by mass or more, preferably 20 to 80% by mass, more preferably 30 to 70% by mass with respect to the total amount of the cosmetic.
  • the blending amount of the polyhydric alcohol is less than 20% by mass, the warm feeling during use cannot be obtained sufficiently.
  • the organic acid and / or inorganic acid used in the warm cosmetic composition of the present invention is an organic acid or inorganic acid used for normal pH adjustment in a skin external preparation such as cosmetics.
  • a skin external preparation such as cosmetics.
  • malic acid, citric acid, lactic acid, phosphoric acid, hydrochloric acid, and the like can be mentioned. Acids that are liquid at normal temperature are preferred, and lactic acid and phosphoric acid are particularly preferred.
  • pH represents a value measured using HORIBA pH METER F-21 (manufactured by Horiba, Ltd.). However, the pH can also be measured with other commercially available pH meters.
  • the organic acid and / or inorganic acid in the cosmetic of the present invention can be used alone or in combination of two or more.
  • the compounding amount of the organic acid and / or inorganic acid is about 0.1 to 3.0% by mass with respect to the total amount of the cosmetic.
  • the blending amount is appropriately determined depending on the pH of the cosmetic to be prepared. In any case, the blending amount is determined so that the pH of the cosmetic is 5.5 or less.
  • the warm cosmetic composition of the present invention can be prepared as an aqueous system that does not contain an oil or an emulsifier.
  • an oil, an oil phase thickener, an emulsifier, and the like can be blended as appropriate to give usability and the desired efficacy, and can be prepared as an emulsion.
  • a water-in-oil emulsion from the viewpoints of usability including stickiness and emulsion stability.
  • the warm cosmetic composition of the present invention is made into a water-in-oil emulsion
  • the oil phase thickener, emulsifier and polyether-modified silicone listed below are further blended to further improve the emulsion stability and feeling of use. Can be made.
  • the oil phase thickener used in the warm cosmetic composition of the present invention refers to one that can impart viscosity to the oil phase.
  • examples include cross-linked siloxane elastomers, dextrin fatty acid esters, hydrophobically modified polysaccharides, fatty acids, waxes and the like.
  • a dry feeling without stickiness can be improved by blending the cross-linked siloxane elastomer.
  • the crosslinkable siloxane elastomer is a siloxane elastomer (silicone elastomer) obtained by three-dimensionally cross-linking polydimethylsiloxane, and includes emulsifiable and non-emulsifiable ones.
  • the emulsifiable cross-linkable siloxane elastomer is not particularly limited, but cross-linkable polyoxyethylene methyl polysiloxane, alkyl group-containing cross-linkable polyoxyethylene methyl polysiloxane, cross-linkable polyglycerin-modified silicone, alkyl group-containing cross-link Type polyglycerin-modified silicone and the like.
  • these emulsifiable cross-linkable siloxane elastomers those commercially available in the form of swelling products swollen in various oils such as silicone oil, mineral oil, triethylhexanoin, squalane and the like can be used. Specific examples include the following.
  • KSG-210 PEG-10 / 15
  • Dimethicone crosspolymer manufactured by Shin-Etsu Chemical Co., Ltd.
  • 9011 silicone elastomer blend PEG-12 / Dimethicone crosspolymer, Toray Dow) Corning Co., Ltd.
  • alkyl group-containing polyoxyethylene methylpolysiloxane crosspolymer examples include KSG-310 (PEG-15 / lauryl dimethicone crosspolymer), KSG-320 (PEG-15 / lauryl dimethicone crosspolymer), KSG-330 (PEG-15 / Lauryl dimethicone crosspolymer), KSG-340 (PEG-10 / lauryl dimethicone crosspolymer, PEG-15 / lauryl dimethicone crosspolymer) (manufactured by Shin-Etsu Chemical Co., Ltd.) and the like.
  • polyglycerin-modified silicone crosspolymer examples include KSG-710 (dimethicone / polyglycerin-3 crosspolymer, manufactured by Shin-Etsu Chemical Co., Ltd.).
  • alkyl group-containing polyglycerin-modified silicone crosspolymer examples include KSG-810 (lauryl dimethicone / polyglycerin 3 cross polymer), KSG-820 (lauryl dimethicone / polyglycerin 3 cross polymer), and KSG-830 (lauryl dimethicone / polyglycerin 3).
  • Cross polymer KSG-840 (lauryl dimethicone / polyglycerin 3 cross polymer) (manufactured by Shin-Etsu Chemical Co., Ltd.), and the like.
  • the non-emulsifying crosslinkable siloxane elastomer is not particularly limited, but is methylpolysiloxane crosspolymer, methylphenylpolysiloxane crosspolymer, vinyl dimethicone / lauryl dimethicone crosspolymer, lauryl polydimethylsiloxyethyl dimethicone / bis-vinyl.
  • Examples include dimethicone cross polymer, alkyl (C30-45) cetearyl dimethicone cross polymer, cetearyl dimethicone cross polymer, and the like.
  • non-emulsifiable cross-linkable siloxane elastomers those commercially available in the form of swollen matter swollen in various oils such as silicone oil, mineral oil, triethylhexanoin, squalane and the like can be used. Specific examples include the following.
  • methylpolysiloxane crosspolymer examples include dimethicone crosspolymers such as 9040 silicone elastomer blend, 9041 silicone elastomer blend, 9045 silicone elastomer blend, EL-8040ID silicone organic blend (above, manufactured by Toray Dow Corning Co., Ltd.), and KSG-15.
  • dimethicone crosspolymers such as 9040 silicone elastomer blend, 9041 silicone elastomer blend, 9045 silicone elastomer blend, EL-8040ID silicone organic blend (above, manufactured by Toray Dow Corning Co., Ltd.), and KSG-15.
  • Dimethicone / vinyl dimethicone crosspolymer such as KSG-16 and KSG-1610 (manufactured by Shin-Etsu Chemical Co., Ltd.), vinyl dimethicone / methicone silsesquioxane crosspolymer such as KSP-100 (manufactured by Shin-Etsu Chemical Co., Ltd.), Examples include polymethylsilsesquioxane such as Tospearl 150KA (manufactured by Momentive Performance Materials).
  • methylphenylpolysiloxane crosspolymer examples include dimethicone / phenyldimethicone crosspolymer such as KSG-18A (dimethicone / phenylvinyldimethicone crosspolymer, manufactured by Shin-Etsu Chemical Co., Ltd.).
  • Examples of the vinyl dimethicone / lauryl dimethicone crosspolymer include KSG-41A, KSG-42A, KSG-43, KSG-44 (manufactured by Shin-Etsu Chemical Co., Ltd.) and the like.
  • Examples of the swelled product of lauryl polydimethylsiloxyethyl dimethicone / bis-vinyl dimethicone cross polymer include KSG-042Z and KSG-045Z (manufactured by Shin-Etsu Chemical Co., Ltd.).
  • alkyl (C30-45) cetearyl dimethicone crosspolymer examples include VELVESIL 125, VELVESIL 034 (manufactured by Momentive Performance Materials).
  • cetearyl dimethicone crosspolymer examples include VELVESIL DM (manufactured by Momentive Performance Materials).
  • the blending amount of the oil phase thickener in the cosmetic of the present invention is 0.5 to 15% by mass, preferably 1.0 to 12% by mass, more preferably 1.5 to 10% by mass with respect to the total amount of the cosmetic. %.
  • the blending amount is less than 0.5% by mass, stickiness may occur.
  • the blending amount exceeds 15% by mass, it may be difficult to prepare a stable cosmetic.
  • the emulsifier used in the warm cosmetic composition of the present invention is relatively high in lipophilicity and can exhibit an emulsion stabilizing effect of an aqueous component and an oil component that are highly blended with a polyhydric alcohol.
  • a polyether-modified silicone or an organic-modified clay mineral having specific properties is preferably used.
  • the polyether-modified silicone as an emulsifier of the present invention has an HLB of 8.0 or less and a viscosity at 25 ° C. of 10,000 mm 2 / s or more, preferably 15,000 mm 2 / s or more, more preferably It is 20,000 mm 2 / s or more. When the viscosity is less than 10,000 mm 2 / s, good emulsification stability cannot be obtained.
  • the organically modified clay mineral used as an emulsifier in the present invention is a kind of colloidal hydrous aluminum silicate having a three-layer structure, and a clay mineral represented by the following general formula (1) is converted to a quaternary ammonium salt type cationic interface.
  • Those modified with an activator can be used.
  • X is Al, Fe (III), Mn (III) or Cr (III)
  • Y is Mg, Fe (II), Ni, Zn or Li
  • Z K, Na or Ca. is there.
  • natural or synthetic montmorillonite such as montmorillonite, saponite, hectorite (in this case, (OH) group in the formula is replaced with fluorine) (commercially available products such as beegum, kunipia, laponite) and It is obtained by treating clay minerals such as sodium silicic mica, synthetic mica known as sodium or lithium teniolite (commercially available products such as Daimonite; manufactured by Topy Industries, Ltd.) with quaternary ammonium salt type cationic surfactants. It is done.
  • the quaternary ammonium salt type cationic surfactant used here is represented by the following general formula (2).
  • R 1 is an alkyl group or benzyl group having 10 to 22 carbon atoms
  • R 2 is a methyl group or an alkyl group having 10 to 22 carbon atoms
  • R 3 and R 4 are alkyl groups or hydroxyalkyl having 1 to 3 carbon atoms
  • the group X represents a halogen atom or a methyl sulfate residue.
  • Examples of the quaternary ammonium salt type cationic surfactant include dodecyltrimethylammonium chloride, myristyltrimethylammonium chloride, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, aralkyltrimethylammonium chloride, behenyltrimethylammonium chloride, myristyldimethylethylammonium.
  • Chloride cetyldimethylethylammonium chloride, stearyldimethylethylammonium chloride, aralkyldimethylethylammonium chloride, behenyldimethylethylammonium chloride, myristyldiethylmethylammonium chloride, cetyldiethylmethylammonium chloride, stearyldiethylmethylammonium chloride, ara Rudiethylmethylammonium chloride, behenyldiethylmethylammonium chloride, benzyldimethylmyristylammonium chloride, benzyldimethylcetylammonium chloride, benzyldimethylstearylammonium chloride, benzyldimethylbehenylammonium chloride, benzylmethylethylcetylammonium chloride, benzylmethylethylstearylammonium chloride, benzyldi
  • organically modified clay minerals include dimethyl distearammonium hectorite (disteadimonium hectorite), dimethylalkylammonium hectorite, benzyldimethylstearylammonium hectorite, distearyldimethylammonium chloride-treated aluminum magnesium silicate Etc. Of these, dimethyl disteammonium hectorite is particularly preferable.
  • examples of commercially available products include Benton 27 (benzyldimethylstearyl ammonium chloride-treated hectorite: manufactured by Elementis Japan) and Benton 38VCG (Distearyldimethylammonium chloride-treated hectorite: manufactured by Elementis Japan).
  • the blending amount of the emulsifier in the cosmetic of the present invention is 0.1 to 5% by mass, preferably 0.5 to 4% by mass, more preferably 0.5 to 3.5% by mass with respect to the total amount of the cosmetic. is there. If the blending amount is less than 0.1% by mass, the emulsion stability tends to be poor, and if it exceeds 5% by mass, stickiness derived from the emulsifier may occur.
  • the emulsion stability can be further improved by blending a polyether-modified silicone having an HLB of 8.0 or less and a viscosity at 25 ° C. of less than 10,000 mm 2 / s.
  • a polyether-modified silicone having an HLB of 8.0 or less and a viscosity at 25 ° C. of less than 10,000 mm 2 / s.
  • those having no alkyl chain in the side chain and having a polyoxyalkylene group in the side chain of the linear or branched silicone skeleton are preferred.
  • polyether-modified silicones it is preferable to use PEG-10 dimethicone or PEG-9 polydimethylsiloxyethyl dimethicone because good emulsion stability can be obtained.
  • 1 type selected from said polyether modified silicone or 2 types or more can be used in combination.
  • the blending amount of the polyether-modified silicone in the cosmetic of the present invention is 0.1 to 10% by mass, preferably 0.3 to 6% by mass, more preferably 1 to 4.5% by mass with respect to the total amount of the cosmetic. is there.
  • the blending amount of the polyether-modified silicone may be 0.1% by mass or less.
  • linseed oil camellia oil, macadamia nut oil, corn oil, olive oil, avocado oil, sasanqua oil, castor oil, safflower oil, kyounin oil, cinnamon oil, jojoba oil, grape oil, sunflower oil, almond oil, rapeseed oil, Oils such as sesame oil, wheat germ oil, rice germ oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, tea seed oil, evening primrose oil, heptanoic acid, octanoic acid, nonanoic acid, decanoic acid, pentadecanoic acid, heptadecanoic acid Fatty acids such as nonadecanoic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid, arachidonic acid, pentaerythritol tetraoctanoate, cetyl octanoate, hex
  • octyl alcohol such as octyl alcohol, isostearyl alcohol, oleyl alcohol, chain silicones such as dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodeca Mention may be made of cyclic silicones such as methylcyclohexasiloxane or silicone oils such as caprylylmethicone. These oil components may be used alone or in combination.
  • the content is preferably 10 to 50% by mass, further 15 to 40% by mass, and more preferably 15 to 30% by mass with respect to the total amount of the cosmetic.
  • the warm cosmetic of the present invention includes other components usually used in cosmetics within a range that does not impair the effects of the present invention, such as powder components, UV protection agents, and various aqueous solvents.
  • Sequestering agents, sugars, amino acids, organic amines, stabilizers, skin nutrients, antioxidants, antioxidant aids, fragrances, and the like can be appropriately blended as necessary.
  • the average emulsion particle diameter of water droplets constituting the emulsion is preferably 10 ⁇ m or less, 5 ⁇ m or less, or 3 ⁇ m or less. By reducing the average emulsified particle size, the emulsion stability is excellent.
  • the warm cosmetic composition according to the present invention is excellent in stability even when a water-soluble drug is blended, and has a good feeling of use with no stickiness despite the high blending of a moisturizing agent. Therefore, the warm sensation according to the present invention can be widely applied to cosmetics, for example, lotion, lotion, milky lotion, serum, cream, massage cosmetics, sunscreen cosmetics, makeup bases, It can be provided in any form such as foundation, lipstick, blusher, eye shadow and the like.
  • the warm cosmetic of the present invention is prepared as an emulsion, and has a hardness of 6 or more, preferably 8 or more, more preferably measured at 25 ° C. using a rheometer (11.3 mm ⁇ , 10 mm penetration). It can be 10 or more. Moreover, it is good also as a balm shape using wax etc. together.
  • the emulsified cosmetic of the present invention having such hardness is excellent in stability, and for example, when filled in a jar container, it retains an appropriate hardness without flowing.
  • the warm cosmetic composition of the present invention can be produced by a conventional method.
  • tranexamic acid is dissolved in a small amount of water in a low pH environment and then prepared by adding a humectant.
  • the water phase component and the oil phase component are respectively stirred and mixed to prepare a uniform water phase portion and an oil phase portion, while adding the water phase portion to the oil phase portion.
  • Table 1 shows changes in the amount of water required for dissolving tranexamic acid when blended with a polyhydric alcohol mixture. Evaluation criteria A: Dissolve sufficiently B: Dissolve partly and remain C: Dissolve hardly
  • Example 1 When polyhydric alcohol is not blended (sample 1), 2 g of tranexamic acid is sufficiently dissolved in 15 g of water, but when polyhydric alcohol is blended, the amount of water can be increased to 22-30 g. Tranexamic acid did not dissolve (Samples 2 to 4), and the amount of water had to be increased to 33 g (Sample 5) in order to be sufficiently dissolved. On the other hand, in Sample 5, although tranexamic acid was sufficiently dissolved, no warm feeling was obtained.
  • Tranexamic acid has strong crystallinity and has a problem of precipitation and solidification with time.
  • Samples were prepared from the components shown in Table 2 below, and the influence of polyhydric alcohol on the precipitation of tranexamic acid was evaluated. That is, after preparing a sample by adding a certain amount of polyhydric alcohol to an aqueous solution in which a certain amount (here 2 g) of tranexamic acid is dissolved in 7.5 times the amount of water, the appearance of each sample at room temperature was observed. The results are also shown in Table 2. Evaluation criteria A: No precipitation was observed. B: Slight precipitation was observed. C: Many precipitations were observed.
  • Evaluation on Warm Feeling Actual use tests were conducted on the prepared samples by 10 expert panelists. Specifically, each of the prepared samples was applied to the faces of 10 panelists, and the warm feeling was evaluated according to the following criteria. Evaluation Criteria A: Eight or more of 10 people evaluated that it was excellent in the warm feeling at the time of use. B: 4 to 7 out of 10 people evaluated that they were excellent in warm feeling during use. C: Three or less people evaluated that it was excellent in the warm feeling at the time of use.

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Abstract

Le but de la présente invention est de fournir une préparation cosmétique à sensation de chaleur qui est très efficace pour conférer une sensation de chaleur et dans laquelle l'acide tranexamique est dans un état suffisamment dissous et dont la précipitation est suffisamment empêchée au cours du temps. La présente invention concerne une préparation cosmétique à sensation de chaleur caractérisée en ce qu'elle comprend de l'acide tranexamique, de l'eau, un alcool polyhydrique, et un acide organique et/ou un acide inorganique, l'eau étant présente dans une quantité allant jusqu'à 5 fois en % en masse la quantité de l'acide tranexamique.
PCT/JP2019/020585 2018-05-29 2019-05-24 Préparation cosmétique à sensation de chaleur WO2019230579A1 (fr)

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JP2020522151A JP7299886B2 (ja) 2018-05-29 2019-05-24 温感化粧料
CN201980035396.4A CN112165932A (zh) 2018-05-29 2019-05-24 温感化妆品
TW108118525A TW202002943A (zh) 2018-05-29 2019-05-29 溫感化妝品

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
US11642324B1 (en) 2022-03-01 2023-05-09 Bio 54, Llc Topical tranexamic acid compositions and methods of use thereof

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JP4726151B2 (ja) * 2008-10-15 2011-07-20 株式会社 資生堂 皮膚外用剤組成物
JP5840107B2 (ja) * 2012-06-17 2016-01-06 コスメディ製薬株式会社 ヒアルロン酸ゲル及びその製造方法

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