WO2019219093A3 - 亚麻酸锌的制备及其在制备抗幽门螺杆菌药物中的应用 - Google Patents

亚麻酸锌的制备及其在制备抗幽门螺杆菌药物中的应用 Download PDF

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Publication number
WO2019219093A3
WO2019219093A3 PCT/CN2019/094664 CN2019094664W WO2019219093A3 WO 2019219093 A3 WO2019219093 A3 WO 2019219093A3 CN 2019094664 W CN2019094664 W CN 2019094664W WO 2019219093 A3 WO2019219093 A3 WO 2019219093A3
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WO
WIPO (PCT)
Prior art keywords
zinc
activated
helicobacter pylori
linoleate
zinc linoleate
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PCT/CN2019/094664
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English (en)
French (fr)
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WO2019219093A2 (zh
Inventor
毕洪凯
黄衍强
杭旭东
曾利平
贾佳
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南京医科大学
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Application filed by 南京医科大学 filed Critical 南京医科大学
Priority to US17/055,129 priority Critical patent/US11203563B2/en
Publication of WO2019219093A2 publication Critical patent/WO2019219093A2/zh
Publication of WO2019219093A3 publication Critical patent/WO2019219093A3/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/03—Monocarboxylic acids
    • C07C57/12—Straight chain carboxylic acids containing eighteen carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

亚麻酸锌的制备及其在制备抗幽门螺杆菌药物中的应用，用无菌水溶解氯化锌，用反应釜将氯化锌溶液加热活化后自然冷却至室温；1-乙基-3-(3-二甲基氨基丙基)碳酰二亚胺盐酸盐、N-羟基硫代琥珀酰亚胺和亚麻酸溶于EMS溶剂，在氮气中活化；活化的氯化锌和活化的亚麻酸加热反应，反应完毕后静置冷却；用透析袋在纯水中透析，至纯水澄清透明；用真空冷冻干燥器干燥，即获得亚麻酸锌。本发明成功制备亚麻酸锌，产率高，且亚麻酸锌抑制幽门螺杆菌效果优良。
PCT/CN2019/094664 2018-05-15 2019-07-04 亚麻酸锌的制备及其在制备抗幽门螺杆菌药物中的应用 WO2019219093A2 (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US17/055,129 US11203563B2 (en) 2018-05-15 2019-07-04 Preparation of zinc linolenate, and application of zinc linolenate in preparing anti-helicobacter pylori drug

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201810462768.9 2018-05-15
CN201810462768.9A CN108623448B (zh) 2018-05-15 2018-05-15 亚麻酸锌的制备及其在制备抗幽门螺杆菌药物中的应用

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WO2019219093A2 WO2019219093A2 (zh) 2019-11-21
WO2019219093A3 true WO2019219093A3 (zh) 2019-12-19

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US (1) US11203563B2 (zh)
CN (1) CN108623448B (zh)
WO (1) WO2019219093A2 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108623448B (zh) 2018-05-15 2019-04-05 南京医科大学 亚麻酸锌的制备及其在制备抗幽门螺杆菌药物中的应用
CN111544451A (zh) * 2020-04-28 2020-08-18 南京医科大学 用于抗幽门螺杆菌的组合物及其应用
CN113072503B (zh) * 2021-03-23 2022-02-01 右江民族医学院 亚麻酸-甲硝唑化合物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2217602A (en) * 1988-04-22 1989-11-01 Medvet Science Pty Ltd Treatment of inflammatory disorders in humans
CN1837177A (zh) * 2005-12-30 2006-09-27 安阳化学工业集团有限责任公司 α—亚麻酸锌的制备方法
CN108623448A (zh) * 2018-05-15 2018-10-09 南京医科大学 亚麻酸锌的制备及其在制备抗幽门螺杆菌药物中的应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2217602A (en) * 1988-04-22 1989-11-01 Medvet Science Pty Ltd Treatment of inflammatory disorders in humans
CN1837177A (zh) * 2005-12-30 2006-09-27 安阳化学工业集团有限责任公司 α—亚麻酸锌的制备方法
CN108623448A (zh) * 2018-05-15 2018-10-09 南京医科大学 亚麻酸锌的制备及其在制备抗幽门螺杆菌药物中的应用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HUANG, YANQIANG ET AL.: "In vitro and in vivo activities of zinc linolenate, a selective antibacterial agent against Helicobacter pylori", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1 April 2019 (2019-04-01), XP055673168 *
HUANG, YANQIANG ET AL.: "The Antibacterial Activity of Zinc Linolenic Acid Small Molecular Compounds to Helicobacter Pylori", PROCEEDINGS OF THE 13TH CHINA ANTIBIOTICS CONFERENCE, 22 November 2017 (2017-11-22), pages 264 *
HUANG, YANQIANG: "In vitro and in vivo activities of zinc linolenate, a selective antibacterial agent against Helicobacter pylori", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 63, no. 6, 1 April 2019 (2019-04-01), XP055673168 *

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WO2019219093A2 (zh) 2019-11-21
CN108623448B (zh) 2019-04-05
CN108623448A (zh) 2018-10-09
US11203563B2 (en) 2021-12-21
US20210107854A1 (en) 2021-04-15

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