WO2019184839A1 - 一种表面具有粘性羟基官能团的纳米纤维保湿面膜及其制备方法和应用 - Google Patents

一种表面具有粘性羟基官能团的纳米纤维保湿面膜及其制备方法和应用 Download PDF

Info

Publication number
WO2019184839A1
WO2019184839A1 PCT/CN2019/079443 CN2019079443W WO2019184839A1 WO 2019184839 A1 WO2019184839 A1 WO 2019184839A1 CN 2019079443 W CN2019079443 W CN 2019079443W WO 2019184839 A1 WO2019184839 A1 WO 2019184839A1
Authority
WO
WIPO (PCT)
Prior art keywords
nanofiber
mask
viscous
mask substrate
preparation
Prior art date
Application number
PCT/CN2019/079443
Other languages
English (en)
French (fr)
Inventor
李明明
唐滈宏
郭秀娟
王钧平
Original Assignee
世霸潜能科研有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 世霸潜能科研有限公司 filed Critical 世霸潜能科研有限公司
Publication of WO2019184839A1 publication Critical patent/WO2019184839A1/zh

Links

Images

Classifications

    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0061—Electro-spinning characterised by the electro-spinning apparatus
    • D01D5/0076—Electro-spinning characterised by the electro-spinning apparatus characterised by the collecting device, e.g. drum, wheel, endless belt, plate or grid
    • D01D5/0084—Coating by electro-spinning, i.e. the electro-spun fibres are not removed from the collecting device but remain integral with it, e.g. coating of prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0212—Face masks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
    • D01D5/00—Formation of filaments, threads, or the like
    • D01D5/0007—Electro-spinning
    • D01D5/0015—Electro-spinning characterised by the initial state of the material
    • D01D5/003—Electro-spinning characterised by the initial state of the material the material being a polymer solution or dispersion
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F9/00—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments

Definitions

  • the invention relates to the technical field of skin care products, in particular to a nanofiber moisturizing mask having a viscous hydroxyl functional group on the surface, a preparation method and application thereof.
  • the ordinary nanofiber spinning mask comprises a nanofiber layer and a mask substrate layer, wherein the nanofiber layer is easily peeled off from the mask substrate layer, and the solution in the prior art is to add a layer of polymer adhesive in the middle of the two layers. Or chemically chemically react between the two layers to increase the adhesion.
  • the adhesive material may cause skin irritation, and the chemical modification method may affect the activity of the active ingredient and increase the cost.
  • Chinese Patent No. CN104114057A discloses a mask impregnated with a liquid cosmetic preparation, and the nanofiber layer is bonded.
  • the viscous materials used include: acrylic, polyurethane, polyester and silicone. Although these viscous materials are inherently viscous, they do not have a moisturizing function.
  • an object of the present invention is to provide a nanofiber hydrating mask having a viscous hydroxyl functional group on the surface, and a preparation method and application thereof.
  • the nanofiber moisturizing mask having a viscous hydroxyl functional group prepared on the surface of the invention can improve the moisturizing function while ensuring that the nanofiber layer and the mask substrate layer are not peeled off.
  • the present invention provides the following technical solutions:
  • a method for preparing a nanofiber moisturizing mask having a viscous hydroxyl functional group on the surface comprises the following steps:
  • a protective layer is bonded to the surface of the viscous nanofiber layer obtained in the step (2) to obtain a nanofiber hydrating mask having a viscous hydroxyl functional group on the surface.
  • the solute in the step (1) comprises the following components by weight: 10 to 80% of glycerin, 10 to 70% of hyaluronic acid, 5 to 60% of polyethylene oxide, 2 to 30% of urea, and urine.
  • the cystatin is 2 to 50%
  • the sodium pyrrolidone carboxylate is 10 to 50%.
  • the step (1) solute further comprises vitamin A and its derivatives, vitamin E and its derivatives, vitamin C and its derivatives, vitamin B5 and its derivatives, propylene glycol, butanediol, pentanediol
  • vitamin A and its derivatives vitamin A and its derivatives
  • vitamin E and its derivatives vitamin E and its derivatives
  • vitamin C and its derivatives vitamin B5 and its derivatives
  • propylene glycol butanediol
  • pentanediol One or more of sorbitol, biogum-2, trehalose, sodium pyrrolidonecarboxylate, lactic acid, ceramide, amino acid, polypeptide, linoleic acid, fruit acid, betaine, and plant extract.
  • the solvent in the step (1) is water, an aqueous ethanol solution or an aqueous acetic acid solution.
  • the electrospinning voltage in the step (2) is 20 to 100 kV
  • the electrospinning time is 0.5 to 8 h
  • the distance between the spinneret and the mask substrate is 10 to 30 cm
  • the moving speed of the mask substrate is The ratio is 0.1 to 2.0 m/min
  • the bolus speed is 0.1 to 2 mL/min.
  • the film resistance of the mask substrate in the step (2) is not higher than 107 ⁇ /sq, and the gram weight is not lower than 10 g/m 2 .
  • the mask substrate is a spunbonded nonwoven fabric, a meltblown nonwoven fabric, a silk mask substrate, a spunlace nonwoven fabric, a cotton fabric, a Tencel nonwoven fabric, a biofiber mask substrate. , hydrogel mask substrate, nanofiber mask substrate or chitosan mask substrate.
  • the present invention also provides a nanofiber moisturizing mask having a viscous hydroxyl functional group on the surface prepared by the preparation method of the above technical solution, comprising a mask substrate, a viscous nanofiber layer and a protective layer which are sequentially laminated, the viscous nanofiber layer comprising glycerin , hyaluronic acid, polyethylene oxide, urea, allantoin and sodium pyrrolidone carboxylate.
  • the viscous nanofiber layer has a thickness of 50 ⁇ m.
  • the invention also provides the application of the nanofiber moisturizing mask with viscous hydroxyl functional groups on the surface of the above technical solution in cosmetic moisturizing.
  • the invention provides a preparation method of a nanofiber moisturizing mask having a viscous hydroxyl functional group on the surface, comprising the steps of: solute comprising glycerin, hyaluronic acid, polyethylene oxide, urea, allantoin and sodium pyrrolidone carboxylate Mixing with a solvent to obtain a spinning solution; spinning the solution to one side of the mask substrate, forming a viscous nanofiber layer on the surface of the mask substrate; bonding the protective layer on the surface of the viscous nanofiber layer to obtain a surface having A viscous hydroxy functional nanofiber hydrating mask.
  • the spinning solution is skillfully mixed with glycerin, hyaluronic acid, polyethylene oxide, urea, allantoin, sodium pyrrolidone carboxylate, and the hydroxy functional group of glycerol is difficult to fully contact the mask base before it has become a nanofiber.
  • the material is therefore not sticky.
  • the surface area of the glycerin is greatly increased, and the hydroxyl functional group sufficiently contacts the mask substrate, thereby having a viscosity, and ensuring the bonding property between the viscous nanofiber and the mask substrate.
  • glycerin, hyaluronic acid, urea, allantoin and sodium pyrrolidone carboxylate have excellent moisturizing properties and improve the moisturizing properties of the nanofiber moisturizing mask.
  • the small molecule moisturizing component (molecular weight less than 500 Da) in the present invention, such as propylene glycol, butanediol, pentanediol, sorbitol, bioglycoside-2, trehalose, urea, sodium pyrrolidone carboxylate, lactic acid, nerve Amide, allantoin, fruit acid, etc.
  • the nanofiber hydrating mask is added with water, the viscous nanofiber layer is transformed into a moisturizing water-blocking layer which smoothes the skin, and the small molecule moisturizing component is released from the viscous nanofiber layer and absorbed by the skin.
  • the common mask takes 15 minutes to use, while the nanofiber moisturizing mask prepared by the invention only takes 3 to 5 minutes, can quickly improve the skin state; macromolecular components (molecular weight greater than 500Da), such as Hyaluronic acid, growth factors, polypeptide proteins, collagen, amino acids, peptides, etc. will remain on the surface of the skin to form a water-locking layer, which has zero burden on the skin.
  • macromolecular components molecular weight greater than 500Da
  • 1 is a schematic view showing the change of the viscous nanofiber layer of the present invention before and after wetting;
  • Example 2 is a micrograph of a viscous nanofiber layer having a viscous hydroxyl functional group on the surface prepared in Example 1 of the present invention
  • Example 3 is a micrograph of an ultra-thin transparent water-blocking layer formed when a nanofiber hydrating mask having a viscous hydroxyl functional group prepared on Example 1 of the present invention is used.
  • the invention provides a preparation method of a nanofiber moisturizing mask having a viscous hydroxyl functional group on the surface, comprising the following steps:
  • a protective layer is bonded to the surface of the viscous nanofiber layer obtained in the step (2) to obtain a nanofiber hydrating mask having a viscous hydroxyl functional group on the surface.
  • the present invention mixes a solute including a glycerin, hyaluronic acid, polyethylene oxide, urea, allantoin, and sodium pyrrolidone carboxylic acid with a solvent to obtain a spinning solution.
  • the solute preferably comprises the following components by weight: 10 to 80% of glycerin, 10 to 70% of hyaluronic acid, 5 to 60% of polyethylene oxide, 2 to 30% of urea, allantoin 2 to 50%, sodium pyrrolidone carboxylate 10 to 50%; more preferably 15% glycerin, 30% hyaluronic acid, 15% polyethylene oxide, 15% urea, 10% allantoin, sodium pyrrolidone carboxylate 15 %.
  • the source of the glycerin, hyaluronic acid, polyethylene oxide, urea, allantoin, and sodium pyrrolidonecarboxylate is not particularly limited, and a commercially available product well known to those skilled in the art may be used.
  • the hydroxy functional group is difficult to sufficiently contact the mask substrate, and therefore is not sticky.
  • the surface area thereof is greatly increased, and the hydroxy functional group is sufficiently in contact with the mask substrate. It is therefore viscous, ensuring the bonding properties between the viscous nanofibers and the mask substrate.
  • glycerin, hyaluronic acid, urea, allantoin, sodium pyrrolidone carboxylate have excellent moisturizing effect, improve the moisturizing performance of nanofiber moisturizing mask, polyethylene oxide provides carrier after electrospinning; It also has an anti-inflammatory effect and can soothe the skin; hyaluronic acid also has a water-locking function.
  • the solute in the spinning solution preferably further comprises preferably vitamin A and its derivatives, vitamin E and its derivatives, vitamin C and its derivatives, vitamin B5 and its derivatives, propylene glycol, butylene glycol , one of pentanediol, sorbitol, biogum-2, trehalose, sodium pyrrolidonecarboxylate, lactic acid, ceramide, amino acid, polypeptide, linoleic acid, fruit acid, betaine, and plant extract or Several.
  • the amino acid is preferably a L-amino acid, more preferably L-arginine, L-glutamine, L-glycine, L-histidine, L-isoleucine, L-leucine, L-lysine, L-valine, L-tyrosine or L-valine.
  • the amino acid has a skin care effect.
  • the polypeptide is preferably palmitoyl pentapeptide-4 or a copper peptide which promotes collagen proliferation, and the copper peptide can reduce inflammation.
  • the content of the other components in the spinning solution of the present invention is not particularly limited.
  • a small molecule moisturizing component (molecular weight less than 500 Da), such as propylene glycol, butylene glycol, pentanediol, sorbitol, biogum-2, trehalose, urea, sodium pyrrolidone carboxylate, lactic acid, ceramide, Allantoin, fruit acid, etc.
  • the nanofiber moisturizing mask is added with water, the viscous nanofiber layer is transformed into a moisturizing water-blocking layer which smoothes the skin, and the small molecule moisturizing component is released from the viscous nanofiber layer and absorbed by the skin without any residue.
  • the ordinary facial mask takes 15 minutes to use, and the nanofiber moisturizing facial mask prepared by the invention only needs 3 to 5 minutes, can quickly improve the skin state, and the macromolecular component (molecular weight is more than 500 Da), such as hyaluronic acid, growth factor, Peptide proteins, collagen, amino acids, peptides, etc. will remain on the surface of the skin to form a water-locking layer, which has zero burden on the skin.
  • the macromolecular component molecular weight is more than 500 Da
  • the plant extract preferably comprises an aloe extract and an almond extract.
  • the solvent is preferably water, an aqueous ethanol solution or an aqueous acetic acid solution.
  • the mass concentration of the solute in the spinning solution is preferably in the range of 5 to 60%, more preferably 20%.
  • the present invention electrospins the spinning solution to one side of the mask substrate to form a viscous nanofiber layer on the surface of the mask substrate.
  • the electrospinning voltage is preferably 20 to 100 kV
  • the electrospinning time is preferably 0.5 to 8 h
  • the distance between the spinneret and the mask substrate is preferably 10 to 30 cm, more preferably 18 cm
  • the mask The moving speed of the substrate is preferably 0.1 to 2.0 m/min
  • the bolus speed is preferably 0.1 to 2 mL/min, and more preferably 1 mL/min.
  • the apparatus for electrospinning of the present invention is not particularly limited, and an electrospinning device well known to those skilled in the art may be employed.
  • the film resistance of the mask substrate is preferably not higher than 107 ⁇ /sq; and the gram weight of the mask substrate is preferably not less than 10 g/m 2 .
  • the mask substrate is preferably a spunbonded nonwoven fabric, a meltblown nonwoven fabric, a silk mask substrate, a spunlace nonwoven fabric, a cotton fabric, a Tencel nonwoven fabric, a biofiber mask substrate, and water.
  • the source of the mask base material of the present invention is not particularly limited, and a commercially available product well known to those skilled in the art may be used.
  • the present invention adheres the protective layer to the surface of the viscous nanofiber layer to obtain a nanofiber hydrating mask having a viscous hydroxyl functional group on the surface.
  • the type of the protective layer and the manner of bonding are not particularly limited in the present invention, and the type of the protective layer and the bonding method well known to those skilled in the art may be used. Specifically, if the protective layer is a pearl film, the bonding method is preferred. For polar forces or direct chaining.
  • the present invention also provides a nanofiber moisturizing mask having a viscous hydroxyl functional group on the surface prepared by the preparation method of the above technical solution, comprising a mask substrate, a viscous nanofiber layer and a protective layer which are sequentially laminated, the viscous nanofiber layer comprising glycerin , hyaluronic acid, polyethylene oxide, urea, allantoin and sodium pyrrolidone carboxylate.
  • the thickness of the viscous nanofiber layer is preferably 50 ⁇ m.
  • the viscous nanofiber layer when the viscous nanofiber layer is in a dry state, the viscous nanofibers are not easily peeled off from the substrate, and in the wet state, the viscous nanofiber layer immediately becomes an ultrathin transparent layer. The water layer is locked, and a large number of moisturizing small molecules that are easily absorbed by the skin are released, as shown in FIG.
  • the invention also provides the application of the nanofiber moisturizing mask with viscous hydroxyl functional groups on the surface of the above technical solution in cosmetic moisturizing.
  • the use of the nanofiber moisturizing mask having a viscous hydroxyl functional group on the surface preferably comprises the following steps:
  • nanofiber moisturizing mask having a viscous hydroxyl functional group on the surface provided by the present invention and the preparation method and application thereof are described in detail below with reference to the examples, but they are not to be construed as limiting the scope of the present invention.
  • glycerin, hyaluronic acid, polyethylene oxide, urea, allantoin, sodium pyrrolidone carboxylate and a solvent to obtain a spinning solution, the solute in the spinning solution comprising the following components by weight: 15% glycerin, Hyaluronic acid 30%, polyethylene oxide 15%, urea 15%, allantoin 10%, pyrrolidone carboxylate 15%.
  • the spinning solution was electrospun on the side of the mask substrate (spunbonded nonwoven fabric, sheet resistance of 107 ⁇ /sq, grammage of 10 g/m 2 ), the electrospinning voltage was 20 kV, and the electrospinning time was 0.5h, the distance between the spinneret and the mask substrate was 18cm, the moving speed of the mask substrate was 0.1m/min, and the bolus speed was 1mL/min, and the viscous nanofiber layer was 50 ⁇ m.
  • the obtained viscous nanofiber layer was observed under a microscope. As a result, as shown in Fig. 2, it can be seen from Fig. 2 that the viscous nanofiber layer produced in this example had a certain viscosity.
  • the viscous nanofiber layer is bonded to the pearl film to obtain a nanofiber hydrating mask having a viscous hydroxyl functional group on the surface.
  • the nanofiber hydrating mask prepared in Example 1 was used:
  • glycerin, hyaluronic acid, polyethylene oxide, urea, allantoin, sodium pyrrolidone carboxylate and a solvent to obtain a spinning solution, the solute in the spinning solution comprising the following components by weight: 15% glycerin, Hyaluronic acid 10%, polyethylene oxide 15%, urea 15%, allantoin 10%, pyrrolidone sodium 15%, hydrolyzed collagen 20%.
  • the spinning solution was electrospun on the side of the mask substrate (spunbond nonwoven fabric, sheet resistance was 100 ⁇ /sq, gram weight was 12 g/m 2 ), the electrospinning voltage was 100 kV, and the electrospinning time was 5.
  • the distance between the spinneret and the mask substrate was 10 cm, the moving speed of the mask substrate was 2.0 m/min, and the bolus speed was 0.1 mL/min, and the viscous nanofiber layer was 50 ⁇ m.
  • the viscous nanofiber layer is bonded to the pearl film to obtain a nanofiber hydrating mask having a viscous hydroxyl functional group on the surface.
  • the moisturizing performance test of the mask prepared in Example 2 was as follows:
  • Test standard People's Republic of China light industry standard QB/T 4256-2011 (Guidelines for the evaluation of moisturizing efficacy of cosmetics).
  • Test ambient temperature 21 ⁇ 1 ° C; humidity: 50 ⁇ 5%, and real-time dynamic monitoring.
  • test substance was used as specified and the data was complete. There were no skin diseases or physical diseases that affected the study of the experiment. No skin treatment or beauty has been performed now or in the last three months.
  • Test instrument Skin moisture tester (Corneometer CM825).
  • Determination procedure Preparation before testing: No product (cosmetic or topical medicine) can be used 2 to 3 days before the test site test. The test site cannot be cleaned within 4 hours before the test. Before testing the skin moisture, the subject needs to clean the inside of the forearm with soap and wipe it off with a dry facial tissue. Sit for 30 minutes in a compliant environment and do not drink water or drinks during this period. The forearm is exposed and placed in a test state to remain relaxed.
  • Descriptive statistics are performed on the measured values of each test area, including quantity, mean, standard deviation, minimum, median and maximum.
  • test data is normally distributed, the t-test method is used for statistical analysis; if the test data is non-normally distributed, the rank sum test method is used for statistical analysis.
  • the statistical methods are all two-tailed tests. The results of the difference are shown in Table 2. As can be seen from Tables 1 and 2, the skin moisture residence time in the test area showed a significant difference, indicating that the mask prepared in this example had a significant moisturizing effect.
  • the solute in the spinning solution comprises the following components by weight: 15% glycerol. Polyethylene oxide 15%, urea 15%, allantoin 10%, pyrrolidone sodium carboxylate 15%, hydrolyzed collagen 30%.
  • the spinning solution was electrospun on the side of the mask substrate (spunbond nonwoven fabric, sheet resistance was 100 ⁇ /sq, gram weight was 12 g/m 2 ), the electrospinning voltage was 100 kV, and the electrospinning time was 5.
  • the distance between the spinneret and the mask substrate was 30 cm, the moving speed of the mask substrate was 1.0 m/min, and the bolus speed was 2 mL/min, and a viscous nanofiber layer of 50 ⁇ m was obtained.
  • the viscous nanofiber layer is bonded to the pearl film to obtain a nanofiber hydrating mask having a viscous hydroxyl functional group on the surface.
  • the solute in the spinning solution includes the following components by weight: glycerin 25%, polyethylene oxide 15 %, allantoin 30%, sodium pyrrolidone carboxylate 30%.
  • the spinning solution was electrospun on the side of the mask substrate (spunbonded nonwoven fabric, sheet resistance of 107 ⁇ /sq, grammage of 15 g/m 2 ), the electrospinning voltage was 100 kV, and the electrospinning time was 5.
  • the distance between the spinneret and the mask substrate was 10 cm, the moving speed of the mask substrate was 2.0 m/min, and the bolus speed was 0.1 mL/min, and the viscous nanofiber layer was 50 ⁇ m.
  • the viscous nanofiber layer is bonded to the pearl film to obtain a nanofiber hydrating mask having a viscous hydroxyl functional group on the surface.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Textile Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

一种保湿面膜，其制备方法包括以下步骤：(1)将包括甘油、透明质酸、聚环氧乙烷、尿素、尿囊素和吡咯烷酮羧酸钠的溶质和溶剂混合，得到纺丝液；(2)将所述步骤(1)得到的纺丝液静电纺丝至面膜基材的一面，在所述面膜基材表面形成粘性纳米纤维层；(3)在所述步骤(2)得到的粘性纳米纤维层的表面贴合保护层，得到保湿面膜。

Description

一种表面具有粘性羟基官能团的纳米纤维保湿面膜及其制备方法和应用
本申请要求于2018年03月29日提交中国专利局、申请号为CN201810273592.2、发明名称为“一种表面具有粘性羟基官能团的纳米纤维保湿面膜及其制备方法和应用”的中国专利申请的优先权，其全部内容通过引用结合在本申请中。
技术领域
本发明涉及护肤用品技术领域，尤其涉及一种表面具有粘性羟基官能团的纳米纤维保湿面膜及其制备方法和应用。
背景技术
普通纳米纤维纺丝面膜包含纳米纤维层和面膜基材层，其中纳米纤维层容易与面膜基材层剥落，现有技术中的解决方法是加一层高分子材料粘合剂在两层中间，或者用化学方法使两层之间发生化学反应，增加粘合度。然而，粘合剂材料有可能产生皮肤过敏，而化学改性的方法会影响有效成分活性，并增加成本，如中国专利CN104114057A公开了一种浸渍有液体化妆品制剂的面膜，将纳米纤维层粘结至非织造织物层，使用的粘性材料包括：丙烯酸，聚氨酯，聚酯和硅氧烷。虽然这些粘性材料本身具有粘性，但是不具备保湿功能。
发明内容
有鉴于此，本发明的目的在于提供一种表面具有粘性羟基官能团的纳米纤维保湿面膜及其制备方法和应用。本发明制得的表面具有粘性羟基官能团的纳米纤维保湿面膜在保证纳米纤维层与面膜基材层不剥落的同时，提高保湿功能。
为了实现上述发明目的，本发明提供以下技术方案：
一种表面具有粘性羟基官能团的纳米纤维保湿面膜的制备方法，包括以下步骤：
(1)将包括甘油、透明质酸、聚环氧乙烷、尿素、尿囊素和吡咯烷酮羧酸钠的溶质和溶剂混合，得到纺丝液；
(2)将所述步骤(1)得到的纺丝液静电纺丝至面膜基材的一面，在所述面膜基材表面形成粘性纳米纤维层；
(3)在所述步骤(2)得到的粘性纳米纤维层的表面贴合保护层，得到表面具有粘性羟基官能团的纳米纤维保湿面膜。
优选地，所述步骤(1)中溶质包括以下重量分数的组分：甘油10～80％，透明质酸10～70％，聚环氧乙烷5～60％，尿素2～30％，尿囊素2～50％，吡咯烷酮羧酸钠10～50％。
优选地，所述步骤(1)溶质中还包括维他命A及其衍生物、维他命E及其衍生物、维他命C及其衍生物、维他命B5及其衍生物、丙二醇、丁二醇、戊二醇、山梨醇、生物糖胶-2、海藻糖、吡咯烷酮羧酸钠、乳酸、神经酰胺、氨基酸、多肽、亚麻仁油酸、果酸、甜菜碱和植物提取物中的一种或几种。
优选地，所述步骤(1)中溶剂为水、乙醇水溶液或醋酸水溶液。
优选地，所述步骤(2)中静电纺丝的电压为20～100kV，静电纺丝的时间为0.5～8h，喷丝头与面膜基材的距离为10～30cm，面膜基材的移动速度为0.1～2.0m/min，推注速度为0.1～2mL/min。
优选地，所述步骤(2)中面膜基材的薄膜电阻不高于107Ω/sq，克重不低于10g/m 2。
优选地，所述步骤(2)中面膜基材为纺粘无纺布、熔喷无纺布、蚕丝面膜基材、水刺无纺布、棉布、天丝无纺布、生物纤维面膜基材、水凝胶面膜基材、纳米纤维面膜基材或壳聚糖面膜基材。
本发明还提供了上述技术方案所述制备方法制得的表面具有粘性羟基官能团的纳米纤维保湿面膜，包括依次层叠的面膜基材、粘性纳米纤维层和保护层，所述粘性纳米纤维层包括甘油、透明质酸，聚环氧乙烷、尿素、尿囊素和吡咯烷酮羧酸钠。
优选地，所述粘性纳米纤维层的厚度为50μm。
本发明还提供了上述技术方案所述表面具有粘性羟基官能团的纳米纤维保湿面膜在美容保湿中的应用。
本发明提供了一种表面具有粘性羟基官能团的纳米纤维保湿面膜的制备方法，包括以下步骤：将包括甘油、透明质酸、聚环氧乙烷、尿素、尿囊素和吡咯烷酮羧酸钠的溶质和溶剂混合，得到纺丝液；纺丝液静电纺 丝至面膜基材的一面，在所述面膜基材表面形成粘性纳米纤维层；在粘性纳米纤维层的表面贴合保护层，得到表面具有粘性羟基官能团的纳米纤维保湿面膜。本发明中，纺丝液巧妙地混合了甘油、透明质酸、聚环氧乙烷、尿素、尿囊素、吡咯烷酮羧酸钠，甘油在尚未成为纳米纤维前，其羟基官能团难以充分接触面膜基材，因此不具粘性，甘油经过静电纺丝成为纳米纤维后，其表面积大幅增加，羟基官能团充分接触面膜基材，因此具有粘性，确保了粘性纳米纤维与面膜基材间的粘结性能。同时甘油、透明质酸、尿素、尿囊素、吡咯烷酮羧酸钠都具有极佳的保湿效能，提高了纳米纤维保湿面膜的保湿性能。
进一步地，本发明中的小分子保湿成分(分子量小于500Da)，如丙二醇，丁二醇，戊二醇，山梨醇，生物糖胶-2，海藻糖，尿素，吡咯烷酮羧酸钠，乳酸，神经酰胺，尿囊素，果酸等，在纳米纤维保湿面膜加水使用之后粘性纳米纤维层转变为使皮肤光滑的保湿锁水层，小分子保湿成分从粘性纳米纤维层中释放，被皮肤吸收，没有任何残余，具有双重保湿功能，普通面膜需要15分钟使用时间，而本发明制备的纳米纤维保湿面膜面膜则只需要3～5分钟，可快速改善皮肤状态；大分子成分(分子量大于500Da)，如透明质酸，生长因子，多肽蛋白，胶原蛋白，氨基酸，多肽等会留在皮肤表面形成锁水层，对皮肤零负担。
说明书附图
图1为本发明粘性纳米纤维层润湿前后变化原理图；
图2为本发明实施例1制得的表面具有粘性羟基官能团的粘性纳米纤维层的显微镜照片；
图3为本发明实施例1制得的表面具有粘性羟基官能团的纳米纤维保湿面膜使用时形成的超薄的透明锁水层的显微镜照片。
具体实施方式
本发明提供了一种表面具有粘性羟基官能团的纳米纤维保湿面膜的制备方法，包括以下步骤：
(1)将包括甘油、透明质酸、聚环氧乙烷、尿素、尿囊素和吡咯烷酮羧酸钠的溶质和溶剂混合，得到纺丝液；
(2)将所述步骤(1)得到的纺丝液静电纺丝至面膜基材的一面，在所述面膜基材表面形成粘性纳米纤维层；
(3)在所述步骤(2)得到的粘性纳米纤维层的表面贴合保护层，得到表面具有粘性羟基官能团的纳米纤维保湿面膜。
本发明将包括甘油、透明质酸、聚环氧乙烷、尿素、尿囊素和吡咯烷酮羧酸钠的溶质和溶剂混合，得到纺丝液。在本发明中，所述溶质优选包括以下重量分数的组分：甘油10～80％，透明质酸10～70％，聚环氧乙烷5～60％，尿素2～30％，尿囊素2～50％，吡咯烷酮羧酸钠10～50％；更优选包括甘油15％，透明质酸30％，聚环氧乙烷15％，尿素15％，尿囊素10％，吡咯烷酮羧酸钠15％。本发明对甘油、透明质酸、聚环氧乙烷、尿素、尿囊素、吡咯烷酮羧酸钠的来源没有特殊的限定，采用本领域技术人员熟知的市售商品即可。
本发明中，所述甘油在尚未成为纳米纤维前，其羟基官能团难以充分接触面膜基材，因此不具粘性，甘油经过静电纺丝成为纳米纤维后，其表面积大幅增加，羟基官能团充分接触面膜基材，因此具有粘性，确保了粘性纳米纤维与面膜基材间的粘结性能。同时甘油、透明质酸、尿素、尿囊素、吡咯烷酮羧酸钠都具有极佳的保湿效能，提高了纳米纤维保湿面膜的保湿性能，聚环氧乙烷提供静电纺丝后的载体；尿囊素还具有抗炎作用，能够舒缓皮肤；透明质酸还具有锁水功能。
在本发明中，所述纺丝液中的溶质优选还包括优选维他命A及其衍生物、维他命E及其衍生物、维他命C及其衍生物、维他命B5及其衍生物、丙二醇、丁二醇、戊二醇、山梨醇、生物糖胶-2、海藻糖、吡咯烷酮羧酸钠、乳酸、神经酰胺、氨基酸、多肽、亚麻仁油酸、果酸、甜菜碱和植物提取物中的一种或几种。在本发明中，所述氨基酸优选为左旋氨基酸，更优选为左旋精氨酸、左旋谷氨酰胺、左旋甘氨酸、左旋组氨酸、左旋异亮氨酸、左旋亮氨酸、左旋赖氨酸、左旋脯氨酸、左旋酪氨酸或左旋缬氨酸。本发明中，氨基酸具有护肤作用。在本发明中，所述多肽优选为棕榈酰五肽-4或铜肽，所述棕榈酰五肽-4能促进胶原蛋白增生，所述铜肽能减少炎症。本发明对所述纺丝液中的其他成分的含量没有特殊的限定。
在本发明中，小分子保湿成分(分子量小于500Da)，如丙二醇，丁二醇，戊二醇，山梨醇，生物糖胶-2，海藻糖，尿素，吡咯烷酮羧酸钠，乳酸，神经酰胺，尿囊素，果酸等，在纳米纤维保湿面膜加水使用之后粘性纳米纤维层转变为使皮肤光滑的保湿锁水层，小分子保湿成分从粘性纳 米纤维层中释放，被皮肤吸收，没有任何残余，普通面膜需要15分钟使用时间，而本发明制备的纳米纤维保湿面膜面膜则只需要3～5分钟，可快速改善皮肤状态，大分子成分(分子量大于500Da)，如透明质酸，生长因子，多肽蛋白，胶原蛋白，氨基酸，多肽等会留在皮肤表面形成锁水层，对皮肤零负担。
在本发明中，所述植物提取物优选包括芦荟萃取物及杏仁提取物。
在本发明中，所述溶剂优选为水、乙醇水溶液或醋酸水溶液。在本发明中，所述纺丝液中溶质的质量浓度范围优选为5～60％，更优选为20％。
得到纺丝液后，本发明将所述纺丝液静电纺丝至面膜基材的一面，在所述面膜基材表面形成粘性纳米纤维层。
在本发明中，所述静电纺丝的电压优选为20～100kV，静电纺丝的时间优选为0.5～8h，喷丝头与面膜基材的距离优选为10～30cm，更优选为18cm，面膜基材的移动速度优选为0.1～2.0m/min，推注速度优选为0.1～2mL/min，更优选为1mL/min。本发明对所述静电纺丝的装置没有特殊的限定，采用本领域技术人员熟知的静电纺丝装置即可。
在本发明中，所述面膜基材的薄膜电阻优选不高于107Ω/sq；所述面膜基材的克重优选不低于10g/m 2。
在本发明中，所述面膜基材优选为纺粘无纺布、熔喷无纺布、蚕丝面膜基材、水刺无纺布、棉布、天丝无纺布、生物纤维面膜基材、水凝胶面膜基材、纳米纤维面膜基材或壳聚糖面膜基材。本发明对所述面膜基材的来源没有特殊的限定，采用本领域技术人员熟知的市售商品即可。
得到粘性纳米纤维层后，本发明在所述粘性纳米纤维层的表面贴合保护层，得到表面具有粘性羟基官能团的纳米纤维保湿面膜。本发明对所述保护层的种类以及贴合的方式没有特殊的限定，采用本领域技术人员熟知的保护层种类和贴合方式即可，具体的，如保护层为珍珠膜，贴合方式优选为极性力作用或直接链合作用。
本发明还提供了上述技术方案所述制备方法制得的表面具有粘性羟基官能团的纳米纤维保湿面膜，包括依次层叠的面膜基材、粘性纳米纤维层和保护层，所述粘性纳米纤维层包括甘油、透明质酸，聚环氧乙烷、尿素、尿囊素和吡咯烷酮羧酸钠。
在本发明中，所述粘性纳米纤维层的厚度优选为50μm。在本发明中，所述粘性纳米纤维层在干爽的状态时，粘性纳米纤维是不容易从基材上剥落的，在湿润的状态时，粘性纳米纤维层会马上变成一层超薄的透明锁水层，同时释放出大量容易被皮肤吸收的保湿小分子，如图1所示。
本发明还提供了上述技术方案所述表面具有粘性羟基官能团的纳米纤维保湿面膜在美容保湿中的应用。
在本发明中，所述表面具有粘性羟基官能团的纳米纤维保湿面膜的使用优选包括以下步骤：
除去保护层；
润湿皮肤；
将所述除去保护层的纳米纤维保湿面膜敷在脸上；
喷水；
等待2～5分钟，移开所述除去保护层的纳米纤维保湿面膜；
轻轻涂抹按摩面部，使大分子有效成分形成保护膜。
下面结合实施例对本发明提供的表面具有粘性羟基官能团的纳米纤维保湿面膜及其制备方法和应用进行详细的说明，但是不能把它们理解为对本发明保护范围的限定。
实施例1
将甘油、透明质酸、聚环氧乙烷、尿素、尿囊素、吡咯烷酮羧酸钠和溶剂混合，得到纺丝液，纺丝液中的溶质包括以下重量分数的组分：甘油15％，透明质酸30％，聚环氧乙烷15％，尿素15％，尿囊素10％，吡咯烷酮羧酸钠15％。
将纺丝液在面膜基材(纺粘无纺布，薄膜电阻为107Ω/sq，克重为10g/m 2)的一面进行静电纺丝，静电纺丝电压为20kV，静电纺丝的时间为0.5h，喷丝头与面膜基材距离为18cm，面膜基材的移动速度为0.1m/min，推注速度为1mL/min，得到粘性纳米纤维层50μm。在显微镜下观察得到的粘性纳米纤维层，结果如图2，由图2可以看出，本实施例制得的粘性纳米纤维层具有一定的粘性。
将粘性纳米纤维层与珍珠膜贴合，得到表面具有粘性羟基官能团的纳米纤维保湿面膜。
实施例1制得的纳米纤维保湿面膜使用过程：
除去保护层；
润湿皮肤；
将所述除去保护层的纳米纤维保湿面膜敷在脸上；
喷水，在显微镜下观察纳米纤维保湿面膜，结果如图3所示，由图3可知，在湿润的状态时，粘性纳米纤维层会马上变成一层超薄的透明锁水层；
等待2～5分钟，移开所述除去保护层的纳米纤维保湿面膜；
轻轻涂抹按摩面部，使大分子有效成分形成保护膜。
实施例2
将甘油、透明质酸、聚环氧乙烷、尿素、尿囊素、吡咯烷酮羧酸钠和溶剂混合，得到纺丝液，纺丝液中的溶质包括以下重量分数的组分：甘油15％，透明质酸10％，聚环氧乙烷15％，尿素15％，尿囊素10％，吡咯烷酮羧酸钠15％，水解胶原蛋白20％。
将纺丝液在面膜基材(纺粘无纺布，薄膜电阻为100Ω/sq，克重为12g/m 2)的一面进行静电纺丝，静电纺丝电压为100kV，静电纺丝的时间为5，喷丝头与面膜基材距离为10cm，面膜基材的移动速度为2.0m/min，推注速度为0.1mL/min，得到粘性纳米纤维层50μm。
将粘性纳米纤维层与珍珠膜贴合，得到表面具有粘性羟基官能团的纳米纤维保湿面膜。
实施例2制得的纳米纤维保湿面膜使用过程：
除去保护层；
润湿皮肤；
将所述除去保护层的纳米纤维保湿面膜敷在脸上；
喷水，在显微镜下观察纳米纤维保湿面膜；
等待2～5分钟，移开所述除去保护层的纳米纤维保湿面膜；
轻轻涂抹按摩面部，使大分子有效成分形成保护膜。
对实施例2制得的面膜的保湿效能测试如下：
测试标准：中华人民共和国轻工行业标准QB/T 4256-2011(化妆品保湿功效评价指南)。
测试环境温度：21±1℃；湿度：50±5％，并且进行实时动态监测。
志愿者条件：
15名女性志愿者。
年龄在18～65岁之间(妊娠或哺乳期妇女除外)。
无严重系统疾病、无免疫缺陷或自身免疫性疾病者。
无活动性过敏性疾病者。
既往对护肤类化妆品无严重过敏史者。
近一月内未曾使用激素类药物及免疫抑制剂者。
现在或最近三个月未参加其它临床试验者。
按规定使用受试物且资料齐全，没有某些皮肤病或身体疾病影响到实验的研究。现在或最近三个月没有进行过皮肤治疗或美容。
测试前所有志愿者应填写知情同意书。
测试仪器：皮肤水分测试仪(Corneometer CM825)。
测定步骤：测试前准备：受试部位测试前2～3天不能使用任何产品(化妆品或外用药品)，测试前4小时内不能清洁受试部位。测试皮肤水分前，受试者需要用香皂清洁前臂内侧，用干的面巾纸擦拭干净。在符合规定的环境中静坐30分钟，期间不能喝水和饮料。前臂暴露，呈测试状态放置，保持放松。
皮肤水份驻留测定：用香皂清洁手臂后，在志愿者手臂内侧标记3×3cm 2测试区域两块，一块为样品测试区，另一块为对照区。在样品测试区喷水，然后敷上3×3cm 2之面膜，再喷水，3分钟后移除面膜。对照区只喷水。以皮肤水分测试仪于3个时间点(0hr(即测试前)，1hr，3hr)分别测试样品测试区的皮肤水分值及对照区的皮肤水分值。测试结果如表1所示。
结果分析：
对各个测试区域的测量值进行描述性统计，包括数量，均值，标准差，最小值，中值和最大值。
计算各测试区域初始值与其它时间点测定值之间的差值，然后利用此差值，统计分析不同时间点产品区和空白时该区的差别。
如果测试数据为正态分布，则采用t检验方法进行统计分析；如果测试数据非正态分布，则采用秩和检验方法进行统计分析。统计方法均为双尾检验。差值结果如表2所示，由表1～2可知，测试区域皮肤水分驻留 时间呈现显著性差异，表示本实施例制得的面膜具有显著性保湿效果。
表1测试样品测试区的皮肤水分值及对照区的皮肤水分值
  0hr(测试前) 1hr 3hr
样品测试区的皮肤水分值(n＝15) 24.4 28.4 29.0
对照区的皮肤水分值(n＝15) 21.3 22.3 22.4
表2皮肤水分值检测结果描述性统计结果
  1hr 3hr
样品测试区差值(n＝15) 4.0(p<0.05) 4.6(p<0.05)
对照区差值(n＝15) 1.0 1.1
实施例3
将甘油、聚环氧乙烷、尿素、尿囊素、吡咯烷酮羧酸钠、水解胶原蛋白和溶剂混合，得到纺丝液，纺丝液中的溶质包括以下重量分数的组分：甘油15％，聚环氧乙烷15％，尿素15％，尿囊素10％，吡咯烷酮羧酸钠15％，水解胶原蛋白30％。
将纺丝液在面膜基材(纺粘无纺布，薄膜电阻为100Ω/sq，克重为12g/m 2)的一面进行静电纺丝，静电纺丝电压为100kV，静电纺丝的时间为5，喷丝头与面膜基材距离为30cm，面膜基材的移动速度为1.0m/min，推注速度为2mL/min，得到粘性纳米纤维层50μm。
将粘性纳米纤维层与珍珠膜贴合，得到表面具有粘性羟基官能团的纳米纤维保湿面膜。
实施例3制得的纳米纤维保湿面膜使用过程：
除去保护层；
润湿皮肤；
将所述除去保护层的纳米纤维保湿面膜敷在脸上；
喷水，在显微镜下观察纳米纤维保湿面膜；
等待2～5分钟，移开所述除去保护层的纳米纤维保湿面膜；
轻轻涂抹按摩面部，使大分子有效成分形成保护膜。
实施例4
将甘油、聚环氧乙烷、尿囊素、吡咯烷酮羧酸钠和溶剂混合，得到纺丝液，纺丝液中的溶质包括以下重量分数的组分：甘油25％，聚环氧乙烷15％，尿囊素30％，吡咯烷酮羧酸钠30％。
将纺丝液在面膜基材(纺粘无纺布，薄膜电阻为107Ω/sq，克重为15g/m 2)的一面进行静电纺丝，静电纺丝电压为100kV，静电纺丝的时间为5，喷丝头与面膜基材距离为10cm，面膜基材的移动速度为2.0m/min，推注速度为0.1mL/min，得到粘性纳米纤维层50μm。
将粘性纳米纤维层与珍珠膜贴合，得到表面具有粘性羟基官能团的纳米纤维保湿面膜。
实施例4制得的纳米纤维保湿面膜使用过程：
除去保护层；
润湿皮肤；
将所述除去保护层的纳米纤维保湿面膜敷在脸上；
喷水，在显微镜下观察纳米纤维保湿面膜；
等待2～5分钟，移开所述除去保护层的纳米纤维保湿面膜；
轻轻涂抹按摩面部，使大分子有效成分形成保护膜。
以上实施例的说明只是用于帮助理解本发明的方法及其核心思想。应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明原理的前提下，还可以对本发明进行若干改进和修饰，这些改进和修饰也落入本发明权利要求的保护范围内。对这些实施例的多种修改对本领域的专业技术人员来说是显而易见的，本文中所定义的一般原理可以在不脱离本发明的精神或范围的情况下在其它实施例中实现。因此，本发明将不会被限制于本文所示的这些实施例，而是要符合与本文所公开的原理和新颖特点相一致的最宽的范围。

Claims (11)

  1. 一种表面具有粘性羟基官能团的纳米纤维保湿面膜的制备方法，包括以下步骤：
    (1)将包括甘油、透明质酸、聚环氧乙烷、尿素、尿囊素和吡咯烷酮羧酸钠的溶质和溶剂混合，得到纺丝液；
    (2)将所述步骤(1)得到的纺丝液静电纺丝至面膜基材的一面，在所述面膜基材表面形成粘性纳米纤维层；
    (3)在所述步骤(2)得到的粘性纳米纤维层的表面贴合保护层，得到表面具有粘性羟基官能团的纳米纤维保湿面膜。
  2. 根据权利要求1所述的制备方法，其特征在于，所述步骤(1)中溶质包括以下重量分数的组分：甘油10～80％，透明质酸10～70％，聚环氧乙烷5～60％，尿素2～30％，尿囊素2～50％，吡咯烷酮羧酸钠10～50％。
  3. 根据权利要求1所述的制备方法，其特征在于，所述步骤(1)溶质中还包括维他命A及其衍生物、维他命E及其衍生物、维他命C及其衍生物、维他命B5及其衍生物、丙二醇、丁二醇、戊二醇、山梨醇、生物糖胶-2、海藻糖、吡咯烷酮羧酸钠、乳酸、神经酰胺、氨基酸、多肽、亚麻仁油酸、果酸、甜菜碱和植物提取物中的一种或几种。
  4. 根据权利要求3所述的制备方法，其特征在于，所述植物提取物包括芦荟萃取物及杏仁提取物。
  5. 根据权利要求1～3任意一项所述的制备方法，其特征在于，所述步骤(1)中溶剂为水、乙醇水溶液或醋酸水溶液。
  6. 根据权利要求1所述的制备方法，其特征在于，所述步骤(2)中静电纺丝的电压为20～100kV，静电纺丝的时间为0.5～8h，喷丝头与面膜基材的距离为10～30cm，面膜基材的移动速度为0.1～2.0m/min，推注速度为0.1～2mL/min。
  7. 根据权利要求1所述的制备方法，其特征在于，所述步骤(2)中面膜基材的薄膜电阻不高于107Ω/sq，克重不低于10g/m 2。
  8. 根据权利要求1或7所述的制备方法，其特征在于，所述步骤(2)中面膜基材为纺粘无纺布、熔喷无纺布、蚕丝面膜基材、水刺无纺布、棉 布、天丝无纺布、生物纤维面膜基材、水凝胶面膜基材、纳米纤维面膜基材或壳聚糖面膜基材。
  9. 权利要求1～8任意一项所述制备方法制得的表面具有粘性羟基官能团的纳米纤维保湿面膜，包括依次层叠的面膜基材、粘性纳米纤维层和保护层，所述粘性纳米纤维层包括甘油、透明质酸，聚环氧乙烷、尿素、尿囊素和吡咯烷酮羧酸钠。
  10. 根据权利要求9所述的纳米纤维保湿面膜，其特征在于，所述粘性纳米纤维层的厚度为50μm。
  11. 权利要求9～10任意一项所述表面具有粘性羟基官能团的纳米纤维保湿面膜在美容保湿中的应用。
PCT/CN2019/079443 2018-03-29 2019-03-25 一种表面具有粘性羟基官能团的纳米纤维保湿面膜及其制备方法和应用 WO2019184839A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201810273592.2A CN108992363B (zh) 2018-03-29 2018-03-29 一种表面具有粘性羟基官能团的纳米纤维保湿面膜及其制备方法和应用
CN201810273592.2 2018-03-29

Publications (1)

Publication Number Publication Date
WO2019184839A1 true WO2019184839A1 (zh) 2019-10-03

Family

ID=64573201

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2019/079443 WO2019184839A1 (zh) 2018-03-29 2019-03-25 一种表面具有粘性羟基官能团的纳米纤维保湿面膜及其制备方法和应用

Country Status (3)

Country Link
CN (1) CN108992363B (zh)
HK (1) HK1255793A2 (zh)
WO (1) WO2019184839A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202100002891A1 (it) * 2021-02-10 2022-08-10 Saati Spa Composizioni polimeriche per la realizzazione di membrane nanofibrose per applicazioni cosmetico-medicali e procedimento per la loro realizzazione
EP4245287A1 (en) * 2022-03-17 2023-09-20 Dacheng Filter Materials Co., Ltd. Process for making a skincare product

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108992363B (zh) * 2018-03-29 2021-04-20 慧丝纳米科技有限公司 一种表面具有粘性羟基官能团的纳米纤维保湿面膜及其制备方法和应用
CN109674685B (zh) * 2019-01-21 2020-04-21 诺斯贝尔化妆品股份有限公司 以出芽短梗酶多糖为骨架的胶原纳米速溶面膜及制备方法
CN110251405B (zh) * 2019-05-24 2023-12-26 西施兰（南阳）药业股份有限公司 一种含有草本成分的抗污染面膜及其制备方法
CN111759749A (zh) * 2020-06-30 2020-10-13 太仓淼品源材料科技有限公司 一种新型的玻尿酸面膜及其制备方法和使用方法
CN114272149A (zh) * 2021-02-02 2022-04-05 辽宁燕阳医疗设备有限公司 一种含有虾青素的敷料的制备方法及应用
CN113288849A (zh) * 2021-06-30 2021-08-24 范祖强 一种面膜及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104114057A (zh) * 2011-11-24 2014-10-22 3M创新有限公司 面膜
CN107106416A (zh) * 2014-12-10 2017-08-29 阿莫生命科学有限公司 美容面膜及其制备方法
CN108992363A (zh) * 2018-03-29 2018-12-14 世霸潜能科研有限公司 一种表面具有粘性羟基官能团的纳米纤维保湿面膜及其制备方法和应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104114057A (zh) * 2011-11-24 2014-10-22 3M创新有限公司 面膜
CN107106416A (zh) * 2014-12-10 2017-08-29 阿莫生命科学有限公司 美容面膜及其制备方法
CN108992363A (zh) * 2018-03-29 2018-12-14 世霸潜能科研有限公司 一种表面具有粘性羟基官能团的纳米纤维保湿面膜及其制备方法和应用

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202100002891A1 (it) * 2021-02-10 2022-08-10 Saati Spa Composizioni polimeriche per la realizzazione di membrane nanofibrose per applicazioni cosmetico-medicali e procedimento per la loro realizzazione
EP4245287A1 (en) * 2022-03-17 2023-09-20 Dacheng Filter Materials Co., Ltd. Process for making a skincare product

Also Published As

Publication number Publication date
CN108992363B (zh) 2021-04-20
CN108992363A (zh) 2018-12-14
HK1255793A2 (zh) 2019-08-23

Similar Documents

Publication Publication Date Title
WO2019184839A1 (zh) 一种表面具有粘性羟基官能团的纳米纤维保湿面膜及其制备方法和应用
JP7288011B2 (ja) 皮膚への適用のための組成物及び方法
DE10084749B4 (de) Substrat, welches mit einer Zusammensetzung behandelt ist, die einen botanischen Extrakt und ein Tensid enthält, sowie Körperpflegeartikel, welcher das behandelte Substrat enthält
WO2001000155A1 (en) Silk protein treatment composition and treated substrate for transfer to skin
KR101895038B1 (ko) 스피큘을 포함하는 용해성 필름 및 이의 용도
WO2020186748A1 (zh) 一种干巾及其加工方法和应用
WO2017011984A1 (zh) 贻贝粘蛋白产品治疗和预防黑色素相关疾病中的应用
MXPA01012649A (es) Distribucion de un substrato sacrificial para inhibir la permeacion de proteasas en la piel.
CN110075004A (zh) 一种复合生物酶医用修复面膜及其制备方法
JP5342455B2 (ja) 細胞調整及び免疫調整のための短い生物活性ペプチド
WO2015163589A1 (ko) 박하초를 유효성분으로 함유하는 화장료 조성물
CN110029443B (zh) 一种山茶籽油纤维膜料的应用
CN114272149A (zh) 一种含有虾青素的敷料的制备方法及应用
WO2019088545A1 (ko) 엑소좀 키트 및 이를 이용한 엑소좀의 경피 투과 증진 방법
CN108354891B (zh) 一种舒缓乳霜及其制备方法
WO2019112238A2 (ko) 줄기세포 유래의 엑소좀을 유효성분으로 포함하는 피부 보습용 화장료 조성물
CN110141678A (zh) 一种藻酸盐理疗液体敷料及其制备方法
CN110141526B (zh) 一种保湿抗皱乳液及其制备方法
CN110339184B (zh) 一种医用修复涂膜剂及其制备方法
CN114569629A (zh) 一种祛疤和皮肤修复的组合物及其制备方法
CN114081844A (zh) 一种含有硫辛酸的敷料的制备方法及应用
DE102006001162A1 (de) Pflasterabdeckung bei atopischer Dermatitis
KR20220066046A (ko) 전방 안검염 및 후방 안검염의 치료를 위한 조성물 및 방법
CN110025512B (zh) 一种黑泥控油祛痘美白面膜及其制备方法
CN115337216B (zh) 一种具有舒缓功效的护肤品组合及其制备

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 19775964

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 19775964

Country of ref document: EP

Kind code of ref document: A1